236 results on '"Seok Ho Song"'
Search Results
2. Inverse-cavity structure for low-threshold miniature lasers
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Gunpyo Kim, Seok Ho Song, and Jae Woong Yoon
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Medicine ,Science - Abstract
Abstract Creating micro and nano lasers, high threshold gain is an inherent problem that have critically restricted their great technological potentials. Here, we propose an inverse-cavity laser structure where its threshold gain in the shortest-cavity regime is order-of-magnitude lower than the conventional cavity configurations. In the proposed structure, a resonant feedback mechanism efficiently transfers external optical gain to the cavity mode at a higher rate for a shorter cavity, hence resulting in the threshold gain reducing with decreasing cavity length in stark contrast to the conventional cavity structures. We provide a fundamental theory and rigorous numerical analyses confirming the feasibility of the proposed structure. Remarkably, the threshold gain reduces down by a factor ~ 10−3 for a vertical-cavity surface-emitting laser structure and ~ 0.17 for a lattice-plasmonic nanocavity structure. Therefore, the proposed approach may produce extremely efficient miniature lasers desirable for variety of applications potentially beyond the present limitations.
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- 2022
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3. Development of a novel multifocal lens using a polarization directed flat lens: possible candidate for a multifocal intraocular lens
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Kyung-Sun Na, Chang Su Lee, Da Ran Kim, Seok Ho Song, Soo Yeon Cho, Eun Chul Kim, Hyun Seung Kim, and Ho Sik Hwang
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Multifocal lens ,Polarization-directed flat: intraocular lens ,Ophthalmology ,RE1-994 - Abstract
Abstract Background A polarization-directed flat (PDF) lens acts as a converging lens with a focal length (f) > 0 and a diverging lens with f
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- 2021
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4. Sulfisoxazole Elicits Robust Antitumour Immune Response Along with Immune Checkpoint Therapy by Inhibiting Exosomal PD‐L1
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Jung Min Shin, Chan‐Hyeong Lee, Soyoung Son, Chan Ho Kim, Jae Ah Lee, Hyewon Ko, Sol Shin, Seok Ho Song, Seong‐Sik Park, Ju‐Hyun Bae, Ju‐Mi Park, Eun‐Ji Choe, Moon‐Chang Baek, and Jae Hyung Park
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combination therapy ,exosomal PD‐L1 ,exosome ,immune checkpoint therapy ,immune escape ,tumor microenvironment ,Science - Abstract
Abstract Despite their potent antitumor activity, clinical application of immune checkpoint inhibitors has been significantly limited by their poor response rates (
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- 2022
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5. A carboxymethyl dextran-based polymeric conjugate as the antigen carrier for cancer immunotherapy
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Jung Min Shin, Seok Ho Song, N. Vijayakameswara Rao, Eun Sook Lee, Hyewon Ko, and Jae Hyung Park
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Carboxymethyl dextran ,Cancer immunotherapy ,Antigen delivery ,Medical technology ,R855-855.5 - Abstract
Abstract Background Antigen-specific cytotoxic T lymphocytes (CTLs), which eliminate target cells bearing antigenic peptides presented by surface major histocompatibility complex (MHC) class I molecules, play a key role in cancer immunotherapy. However, the majority of tumors are not immunologically rejected since they express self-antigens which are not recognized by CTLs as foreign. To foreignize these tumors for CTL-mediated immunological rejection, it is essential to develop carriers that can effectively deliver foreign antigens to cancer cells. Methods A polymeric conjugate, composed of a carboxymethyl dextran (CMD) as the backbone and ovalbumin (OVA) as a model foreign antigen, was prepared to investigate its potential as the antigen carrier for cancer immunotherapy. Results An in vitro cellular uptake study showed that the conjugate was successfully taken up by TC-1 cervical cancer cells. When CMD-OVA was systemically administered to tumor-bearing mice, the strong fluorescence signal was observed at the tumor site over the whole period of time period, suggesting high tumor targetability of the conjugate. Compared to free OVA, CMD-OVA induced significantly higher antigen presentation at the tumor site. Conclusions The CMD-OVA conjugate can effectively deliver the antigen to the tumor site, implying its high potential as the antigen carrier for cancer immunotherapy.
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- 2018
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6. Observation of an anti-PT-symmetric exceptional point and energy-difference conserving dynamics in electrical circuit resonators
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Youngsun Choi, Choloong Hahn, Jae Woong Yoon, and Seok Ho Song
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Science - Abstract
The study of parity-time (PT) symmetric optical systems has recently attracted much attention. Here, the authors experimentally study an anti-PT symmetric circuit system and observe an exceptional point with an inverse PT symmetry breaking transition and energy-difference conserving dynamics.
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- 2018
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7. Extremely broadband, on-chip optical nonreciprocity enabled by mimicking nonlinear anti-adiabatic quantum jumps near exceptional points
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Youngsun Choi, Choloong Hahn, Jae Woong Yoon, Seok Ho Song, and Pierre Berini
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Science - Abstract
Nonreciprocal optical devices can be designed based on symmetry breaking at singular points associated with non-Hermitian physics. Here, Choiet al. theoretically show that encircling of exceptional points enables the broadband operation and chip integration of such devices.
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- 2017
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8. Observation of exceptional points in reconfigurable non-Hermitian vector-field holographic lattices
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Choloong Hahn, Youngsun Choi, Jae Woong Yoon, Seok Ho Song, Cha Hwan Oh, and Pierre Berini
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Science - Abstract
Non-Hermitian Hamiltonians have attracted significant attention because of the unconventional wave-dynamic effects they allow. Here, Hahn et al. report reconfigurable non-Hermitian photonic lattices that permit versatile control of real and imaginary sub-lattices in the optical spectral domain.
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- 2016
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9. Addendum: Observation of an anti-PT-symmetric exceptional point and energy-difference conserving dynamics in electrical circuit resonators
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Youngsun Choi, Choloong Hahn, Jae Woong Yoon, and Seok Ho Song
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Science - Published
- 2019
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10. Curvature-sensing peptide inhibits tumour-derived exosomes for enhanced cancer immunotherapy
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Sol Shin, Hyewon Ko, Chan Ho Kim, Bo Kyeong Yoon, Soyoung Son, Jae Ah Lee, Jung Min Shin, Jeongjin Lee, Seok Ho Song, Joshua A. Jackman, and Jae Hyung Park
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Mechanics of Materials ,Mechanical Engineering ,General Materials Science ,General Chemistry ,Condensed Matter Physics - Published
- 2023
11. Functionally Masked Antibody to Uncouple Immune-Related Toxicities in Checkpoint Blockade Cancer Therapy
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Seok Ho Song, Torsha Ghosh, Dong Gil You, Hyeyeon Joo, Jeongjin Lee, Jaeah Lee, Chan Ho Kim, Jueun Jeon, Sol Shin, and Jae Hyung Park
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General Engineering ,General Physics and Astronomy ,General Materials Science - Published
- 2023
12. A Principle of Non‐Hermitian Wave Modulators by Indefinitely Small Physical Controls
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Youngsun Choi, Yu Sung Choi, Seok Ho Song, Kyungsik Yu, Nimrod Moiseyev, and Jae Woong Yoon
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Condensed Matter Physics ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials - Published
- 2023
13. Biomaterials as Antigen Delivery Carrier for Cancer Immunotherapy
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Wooram Um, Anuradha Gupta, Seok Ho Song, Chan Ho Kim, and Jae Hyung Park
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Polymers and Plastics ,General Chemical Engineering ,Organic Chemistry ,Materials Chemistry - Published
- 2021
14. Topological beaming of light
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Ki Young Lee, Seungjin Yoon, Seok Ho Song, and Jae Woong Yoon
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Multidisciplinary - Abstract
Nanophotonic light emitters are key components in numerous application areas because of their compactness and versatility. Here, we propose a topological beam emitter structure that takes advantage of submicrometer footprint size, small divergence angle, high efficiency, and adaptable beam shaping capability. The proposed structure consists of a topological junction of two guided-mode resonance gratings inducing a leaky Jackiw-Rebbi state resonance. The leaky Jackiw-Rebbi state leads to in-plane optical confinement with funnel-like energy flow and enhanced emission probability, resulting in highly efficient optical beam emission. In addition, the structure allows adaptable beam shaping for any desired positive definite profiles by means of Dirac mass distribution control, which can be directly encoded in lattice geometry parameters. Therefore, the proposed approach provides highly desirable properties for efficient micro–light emitters and detectors in various applications including display, solid-state light detection and ranging, laser machining, label-free sensors, optical interconnects, and telecommunications.
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- 2022
15. Geometric-phase intraocular lenses with multifocality
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Seok-Ho Song
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We demonstrate a new type of multifocal and extended depth of focus (EDOF) intraocular lenses (IOLs) embedding μm-thin geometric phase (GP) lens layers. As an emerging approach for lens phase design, the GP modulated IOLs outperform conventional diffractive IOLs in multifocality while completely avoiding the clinically undesirable demand for additional surface patterns to standard monofocal IOL designs. The number of foci and light splitting ratio of the GP IOLs are adjusted by changing the number of stacked GP layers and the thickness of each layer. Bifocal and trifocal GP IOLs are fabricated by radial alignment of anisotropic orientation in UV-curable liquid crystal polymers. After characterizing the defocus image and modulation transfer function of the GP IOLs, it is expected that GP IOLs will alleviate the most common problems associated with multifocal and EDOF IOLs, blurred vision and photic phenomena caused by light scattering and posterior capsule opacification.
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- 2022
16. Topological guided-mode resonances at non-Hermitian nanophotonic interfaces
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Ki Young Lee, Kwang Wook Yoo, Youngsun Choi, Jae Woong Yoon, Seok Ho Song, Gunpyo Kim, and Sangmo Cheon
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Physics ,Guided-mode resonance ,QC1-999 ,Nanophotonics ,Mode (statistics) ,guided-mode resonance ,02 engineering and technology ,non-hermitian effect ,021001 nanoscience & nanotechnology ,01 natural sciences ,Hermitian matrix ,Atomic and Molecular Physics, and Optics ,subwavelength grating ,Electronic, Optical and Magnetic Materials ,topological effect ,Quantum mechanics ,0103 physical sciences ,Electrical and Electronic Engineering ,010306 general physics ,0210 nano-technology ,Biotechnology - Abstract
The topological properties of photonic microstructures are of great interest because of their experimental feasibility for fundamental study and potential applications. Here, we show that robust guided-mode-resonance states exist in photonic domain-wall structures whenever the complex photonic band structures involve certain topological correlations in general. Using the non-Hermitian photonic analogy of the one-dimensional Dirac equation, we derive essential conditions for photonic Jackiw-Rebbi-state resonances taking advantage of unique spatial confinement and spot-like spectral features which are remarkably robust against random parametric errors. Therefore, the proposed resonance configuration potentially provides a powerful method to create compact and stable photonic resonators for various applications in practice.
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- 2021
17. Self-immolative polymer-based immunogenic cell death inducer for regulation of redox homeostasis
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Jueun Jeon, Been Yoon, Anup Dey, Seok Ho Song, Yuce Li, Hyeyeon Joo, and Jae Hyung Park
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Biomaterials ,Mechanics of Materials ,Biophysics ,Ceramics and Composites ,Bioengineering - Published
- 2023
18. Association Between Visceral Hypersensitivity in Irritable Bowel Syndrome, Intestinal Microbiota, and Mast Cells: How to Detect Mast Cells Using Confocal Microscopy
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Jiwon Lee, Kwang-Geol Lee, Seok Ho Song, Juil Hwang, Ji Sook Kim, Chungha Lee, Kang Nyeong Lee, and Oh Young Lee
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Pathology ,medicine.medical_specialty ,business.industry ,Gastroenterology ,medicine.disease ,law.invention ,Confocal microscopy ,law ,Medicine ,Neurology (clinical) ,Mast (botany) ,business ,Letter to the Editor ,Irritable bowel syndrome - Published
- 2021
19. PD-L1 siRNA-hyaluronic acid conjugate for dual-targeted cancer immunotherapy
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Suyeon Kim, Roun Heo, Seok Ho Song, Kwon-Ho Song, Jung Min Shin, Se Jin Oh, Hyo-Jung Lee, Jo Eun Chung, Jae Hyung Park, and Tae Woo Kim
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Mice, Inbred C57BL ,Mice ,Antigens, Neoplasm ,Ovalbumin ,Neoplasms ,Tumor Microenvironment ,Pharmaceutical Science ,Animals ,Immunotherapy ,Nanoconjugates ,Hyaluronic Acid ,RNA, Small Interfering ,B7-H1 Antigen - Abstract
"Foreignization" of tumor cells via delivery of a non-self foreign antigen (Ag) into tumors is an appealing strategy to initiate anti-tumor immunity that can facilitate tumor rejection by pre-existing foreign-Ag-reactive T cells. However, the immune-suppressive factors in the tumor microenvironment (TME) limit the durable and potent immune response of these cells against tumor antigens, stressing the need for improved tumor-foreignization strategies. Here, we demonstrate that blockade of programmed cell death ligand 1 (PD-L1) on both tumor cells and dendritic cells (DCs) can markedly potentiate the induction of tumor-reactive T cells, thereby strengthening the anti-tumor immunity ignited by tumor-foreignization. Specifically, we developed a polymeric nanoconjugate (PEG-HA-OVA/PPLs), consisting of siPD-L1-based polyplexes, PEGylated hyaluronic acid as the CD44-targeting moiety, and ovalbumin (OVA) as a model foreign antigen. Notably, PEG-HA-OVA/PPLs were simultaneously delivered into CD44
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- 2022
20. Examining Servant Leadership and Burnout among NCAA Student-Athletes.
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Umanets, Yuliana and Seok-Ho Song
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SERVANT leadership , *PSYCHOLOGICAL burnout , *STUDENT leadership , *COLLEGE athletes , *REGRESSION analysis - Abstract
This research examined the impact of servant leadership on burnout. More specifically, this study evaluated the degree of association between NCAA Divisions I-III student-athletes' perceptions of coaches' servant leadership and the student athletes' burnout scores. The researchers utilized the quantitative methodology protocols to collect and analyze the participants' responses to the modified version of the Servant Leadership (SL-28) scale, Athlete Burnout Questionnaire (ABQ), and Demographic Questionnaire. The statistical analysis revealed a significant negative correlation between total servant leadership and total burnout scores. Researchers performed the multivariate regression analysis with the five servant leadership dimension scores as independent variables and three burnout dimensions as the dependent variables. All tests produced significant models indicating significant negative correlations between the dimensions. The additional analysis showed that the participant's gender was a significant predictor of total ABQ scores. This study was the first to examine servant leadership and burnout correlation within collegiate athletics; thus, this research shows the potential direction for further investigation of these variables. [ABSTRACT FROM AUTHOR]
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- 2023
21. All-solid-state spatial light modulator with independent phase and amplitude control for three-dimensional LiDAR applications
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Byung Gil Jeong, Mark L. Brongersma, Yong Young Park, Chang Bum Lee, Kyoung-ho Ha, Jisoo Kyoung, Sunil Kim, Sang-Wook Kim, Junghyun Park, Byoung Lyong Choi, Seok Ho Song, Jungwoo Kim, Hyuck Choo, Sungwoo Hwang, Jaeduck Jang, Ji San Lee, Tatsuhiro Otsuka, Duhyun Lee, Changgyun Shin, Ki Yeon Yang, and In-Oh Hwang
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Physics ,Spatial light modulator ,business.industry ,Biomedical Engineering ,Phase (waves) ,Optical communication ,Bioengineering ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,Atomic and Molecular Physics, and Optics ,0104 chemical sciences ,Amplitude ,Optics ,Miniaturization ,General Materials Science ,Electrical and Electronic Engineering ,Reflection coefficient ,0210 nano-technology ,business ,Phase modulation ,Digital holography - Abstract
Spatial light modulators are essential optical elements in applications that require the ability to regulate the amplitude, phase and polarization of light, such as digital holography, optical communications and biomedical imaging. With the push towards miniaturization of optical components, static metasurfaces are used as competent alternatives. These evolved to active metasurfaces in which light-wavefront manipulation can be done in a time-dependent fashion. The active metasurfaces reported so far, however, still show incomplete phase modulation (below 360°). Here we present an all-solid-state, electrically tunable and reflective metasurface array that can generate a specific phase or a continuous sweep between 0 and 360° at an estimated rate of 5.4 MHz while independently adjusting the amplitude. The metasurface features 550 individually addressable nanoresonators in a 250 × 250 μm2 area with no micromechanical elements or liquid crystals. A key feature of our design is the presence of two independent control parameters (top and bottom gate voltages) in each nanoresonator, which are used to adjust the real and imaginary parts of the reflection coefficient independently. To demonstrate this array’s use in light detection and ranging, we performed a three-dimensional depth scan of an emulated street scene that consisted of a model car and a human figure up to a distance of 4.7 m. By controlling two voltage gates separately from one another, a spatial light modulator has been made that can continuously vary the phase of 360 degrees while independently adjusting the amplitude.
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- 2020
22. Metasurface-driven OLED displays beyond 10,000 pixels per inch
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Jisoo Kyoung, Jun Cheol Bae, Hyun Koo, Sung Hyun Han, Sung Han Kim, Sunjin Song, Won-Jae Joo, Sung-Hoon Lee, Myong Jong Kwon, Mark L. Brongersma, Ara Jo, Seok Ho Song, Majid Esfandyarpour, Young-Nam Kwon, and Sungwoo Hwang
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Multidisciplinary ,Materials science ,Pixel ,business.industry ,02 engineering and technology ,021001 nanoscience & nanotechnology ,01 natural sciences ,Nanoimprint lithography ,law.invention ,010309 optics ,law ,Modulation ,0103 physical sciences ,OLED ,Optoelectronics ,Augmented reality ,0210 nano-technology ,business ,Luminescence ,Pixel density ,Diode - Abstract
Metasurface-based microdisplays Organic light-emitting diodes (OLEDs) have found wide application in high-resolution, large-area televisions and the handheld displays of smartphones and tablets. With the screen located some distance from the eye, the typical number of pixels per inch is in the region of hundreds. For near-eye microdisplays—for example, in virtual and augmented reality applications—the required pixel density runs to several thousand pixels per inch and cannot be met by present display technologies. Joo et al. developed a full-color, high-brightness OLED design based on an engineered metasurface as a tunable back-reflector. An ultrahigh density of 10,000 pixels per inch readily meets the requirements for the next-generation microdisplays that can be fabricated on glasses or contact lenses. Science , this issue p. 459
- Published
- 2020
23. Chemiluminescence resonance energy transfer-based immunostimulatory nanoparticles for sonoimmunotherapy
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Jueun Jeon, Been Yoon, Seok Ho Song, Wooram Um, Yeari Song, Jeongjin Lee, Dong Gil You, Jae Yoon An, and Jae Hyung Park
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Luminescence ,Ultrasonic Therapy ,Biophysics ,Bioengineering ,Hydrogen Peroxide ,Biomaterials ,Mice ,Energy Transfer ,Mechanics of Materials ,Cell Line, Tumor ,Ceramics and Composites ,Animals ,Nanoparticles ,Reactive Oxygen Species - Abstract
Sonodynamic therapy (SDT) has recently emerged as a promising alternative to photodynamic therapy because of its applicability in treating deeply located tumors accessible by ultrasound (US). However, the therapeutic potential of conventional sonosensitizers is limited by the low quantum yield of reactive oxygen species (ROS) and poor immune responses eliciting canonical apoptosis of cancer cells. Herein, we report chemiluminescence resonance energy transfer (CRET)-based immunostimulatory nanoparticles (iCRET NPs) for sonoimmunotherapy, which not only amplify the ROS quantum yield of sonosensitizers but also generate carbon dioxide (CO
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- 2021
24. Design Considerations for the Liquid Air Energy Storage System Integrated to Nuclear Steam Cycle
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Seok Ho Song, Jeong-Ik Lee, and Jin-Young Heo
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Rankine cycle ,Technology ,Power station ,QH301-705.5 ,QC1-999 ,Cryogenic energy storage ,ComputerApplications_COMPUTERSINOTHERSYSTEMS ,law.invention ,law ,Liquid air ,Nuclear power plant ,nuclear power ,General Materials Science ,Biology (General) ,Process engineering ,Instrumentation ,QD1-999 ,Fluid Flow and Transfer Processes ,load following operation ,business.industry ,Process Chemistry and Technology ,Physics ,General Engineering ,liquid air energy storage (LAES) ,Nuclear power ,Engineering (General). Civil engineering (General) ,Computer Science Applications ,Power (physics) ,Renewable energy ,Chemistry ,Environmental science ,TA1-2040 ,business - Abstract
A nuclear power plant is one of the power sources that shares a large portion of base-load. However, as the proportion of renewable energy increases, nuclear power plants will be required to generate power more flexibly due to the intermittency of the renewable energy sources. This paper reviews a layout thermally integrating the liquid air energy storage system with a nuclear power plant. To evaluate the performance realistically while optimizing the layout, operating nuclear power plant conditions are used. After revisiting the analysis, the optimized performance of the proposed system is predicted to achieve 59.96% of the round-trip efficiency. However, it is further shown that external environmental conditions could deteriorate the performance. For the design of liquid air energy storage-nuclear power plant integrated systems, both the steam properties of the linked plants and external factors should be considered.
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- 2021
25. Synthetic Topological Nodal Phase in Bilayer Resonant Gratings
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Ki Young Lee, Kwang Wook Yoo, Sangmo Cheon, Won-Jae Joo, Jae Woong Yoon, and Seok Ho Song
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General Physics and Astronomy - Abstract
The notion of synthetic dimensions in artificial photonic systems has received considerable attention as it provides novel methods for exploring hypothetical topological phenomena as well as potential device applications. Here, we present nanophotonic manifestation of a two-dimensional topological nodal phase in bilayer resonant grating structures. Using the mathematical analogy between a topological semimetal and vertically asymmetric photonic lattices, we show that the interlayer shift simulates an extra momentum dimension for creating a two-dimensional topological nodal phase. We present a theoretical model and rigorous numerical analyses showing the two nodal points that produce a complex gapless band structure and localized edge states in the topologically nontrivial region. Therefore, our results provide a practical scheme for producing high-dimensional topological effects in simple low-dimensional photonic structures.
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- 2021
26. Development of a Distributed Optical Thermometry Technique for Battery Cells
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Seong-O Yang, Seungmin Lee, Seok Ho Song, and Jihyung Yoo
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Fluid Flow and Transfer Processes ,History ,Polymers and Plastics ,Mechanical Engineering ,Business and International Management ,Condensed Matter Physics ,Industrial and Manufacturing Engineering - Published
- 2021
27. Recruitment of dendritic cells using ‘find-me’ signaling microparticles for personalized cancer immunotherapy
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Jae Ah Lee, Jung Min Shin, Seok Ho Song, Chan Ho Kim, Soyoung Son, Sol Shin, and Jae Hyung Park
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Mice, Inbred C57BL ,Biomaterials ,Mice ,Mechanics of Materials ,Neoplasms ,Tumor Microenvironment ,Biophysics ,Ceramics and Composites ,Animals ,Bioengineering ,Dendritic Cells ,Immunotherapy ,Cancer Vaccines - Abstract
Therapeutic cancer vaccines have attracted attention because of their potential to prime cytotoxic T cells, which are highly antigen (Ag)-specific, allowing personalized cancer immunotherapy. However, because of their low immunogenicity, cancer vaccines have been used in only a few types of cancers in clinics, primarily because of the poor Ag presentation of dendritic cells (DCs). To address these limitations of cancer vaccines, we show that 'find-me' signaling polymeric microparticles (F-PMs) bearing tumor lysate as an Ag can efficiently recruit DCs and facilitate antigen presentation. When subcutaneously injected into tumor-bearing mice, F-PMs significantly increased mature DCs in tumor-draining lymph nodes by eliciting adenosine triphosphate (ATP)-induced chemotaxis, resulting in high antitumor efficacy. CD8
- Published
- 2022
28. Direct observation of time-asymmetric breakdown of the standard adiabaticity around an exceptional point
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Youngsun Choi, Jong Kyun Hong, Seok Ho Song, Jae Woong Yoon, and Yeonghwa Ryu
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Physics ,Direct observation ,General Physics and Astronomy ,lcsh:Astrophysics ,Observable ,02 engineering and technology ,021001 nanoscience & nanotechnology ,01 natural sciences ,lcsh:QC1-999 ,Set (abstract data type) ,Singularity ,lcsh:QB460-466 ,0103 physical sciences ,Limit (mathematics) ,Statistical physics ,010306 general physics ,0210 nano-technology ,Adiabatic process ,lcsh:Physics ,Eigenvalues and eigenvectors ,Topology (chemistry) - Abstract
Recent study on topological operations around an exceptional point singularity has shown remarkably robust chiral processes that potentially create time-asymmetric or nonreciprocal systems and devices. Nevertheless, direct observation of the entire dynamics in the courses of the topological operations has not been revealed in experiments thus far. Here, we report a comprehensive experimental study on fully time-resolved dynamic-state evolution passages during encircling-an-exceptional-point operations. Using dynamically tunable electrical oscillators, we create a self-intersecting eigenvalue topology with an unprecedented accuracy and experimentally confirm that the time-asymmetric breakdown of the standard adiabaticity is indeed unavoidable when the system encircles an exceptional point in the canonical adiabatic limit. We further discuss the impact of parasitic noises on the time-asymmetric mode-transfer performance and subsequent considerations for practical design requirements. So far, chiral topological operations around an exceptional point singularity were experimentally observable through the system’s initial and final states only. Here, the authors propose an experimental set up that allows them to access the full time-resolved evolution during encircling-an-exceptional-point operations.
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- 2020
29. Metabolically engineered stem cell-derived exosomes to regulate macrophage heterogeneity in rheumatoid arthritis
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Gyeong Taek Lim, Jungmi Lee, Wooram Um, Jae Hyung Park, Dong Gil You, Yong Woo Cho, Byeong Hoon Oh, Dong-Gyu Jo, Seok Ho Song, and Seunglee Kwon
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musculoskeletal diseases ,Arthritis ,02 engineering and technology ,Biology ,Exosomes ,Arthritis, Rheumatoid ,03 medical and health sciences ,Mice ,medicine ,Macrophage ,Animals ,Humans ,skin and connective tissue diseases ,Research Articles ,030304 developmental biology ,Therapeutic strategy ,0303 health sciences ,Multidisciplinary ,Macrophages ,Stem Cells ,SciAdv r-articles ,Life Sciences ,Cell Biology ,021001 nanoscience & nanotechnology ,medicine.disease ,Phenotype ,Arthritis, Experimental ,Microvesicles ,MicroRNAs ,Rheumatoid arthritis ,Cancer research ,Stem cell ,0210 nano-technology ,Reprogramming ,Research Article - Abstract
Surface engineering of exosomes enhances the therapeutic efficacy of rheumatoid arthritis by macrophage reprogramming., Despite the remarkable advances in therapeutics for rheumatoid arthritis (RA), a large number of patients still lack effective countermeasures. Recently, the reprogramming of macrophages to an immunoregulatory phenotype has emerged as a promising therapeutic strategy for RA. Here, we report metabolically engineered exosomes that have been surface-modified for the targeted reprogramming of macrophages. Qualified exosomes were readily harvested from metabolically engineered stem cells by tangential flow filtration at a high yield while maintaining their innate immunomodulatory components. When systemically administered into mice with collagen-induced arthritis, these exosomes effectively accumulated in the inflamed joints, inducing a cascade of anti-inflammatory events via macrophage phenotype regulation. The level of therapeutic efficacy obtained with bare exosomes was achievable with the engineered exosomes of 10 times less dose. On the basis of the boosted nature to reprogram the synovial microenvironment, the engineered exosomes display considerable potential to be developed as a next-generation drug for RA.
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- 2020
30. Time-asymmetric loop around an exceptional point over the full optical communications band
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Jae Woong Yoon, Youngsun Choi, Hong-Seok Lee, Pierre Berini, Yongsung Kim, Gunpyo Kim, Jai Kwang Shin, Choloong Hahn, Chang Seung Lee, Ki Yeon Yang, Jeong Yub Lee, and Seok Ho Song
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Physics ,Signal processing ,Multidisciplinary ,Silicon photonics ,Optical isolator ,business.industry ,Optical communication ,Physics::Optics ,02 engineering and technology ,021001 nanoscience & nanotechnology ,01 natural sciences ,Hermitian matrix ,law.invention ,law ,0103 physical sciences ,Broadband ,Dissipative system ,Optoelectronics ,Photonics ,010306 general physics ,0210 nano-technology ,business - Abstract
Topological operations around exceptional points1–8—time-varying system configurations associated with non-Hermitian singularities—have been proposed as a robust approach to achieving far-reaching open-system dynamics, as demonstrated in highly dissipative microwave transmission3 and cryogenic optomechanical oscillator4 experiments. In stark contrast to conventional systems based on closed-system Hermitian dynamics, environmental interferences at exceptional points are dynamically engaged with their internal coupling properties to create rotational stimuli in fictitious-parameter domains, resulting in chiral systems that exhibit various anomalous physical phenomena9–16. To achieve new wave properties and concomitant device architectures to control them, realizations of such systems in application-abundant technological areas, including communications and signal processing systems, are the next step. However, it is currently unclear whether non-Hermitian interaction schemes can be configured in robust technological platforms for further device engineering. Here we experimentally demonstrate a robust silicon photonic structure with photonic modes that transmit through time-asymmetric loops around an exceptional point in the optical domain. The proposed structure consists of two coupled silicon-channel waveguides and a slab-waveguide leakage-radiation sink that precisely control the required non-Hermitian Hamiltonian experienced by the photonic modes. The fabricated devices generate time-asymmetric light transmission over an extremely broad spectral band covering the entire optical telecommunications window (wavelengths between 1.26 and 1.675 micrometres). Thus, we take a step towards broadband on-chip optical devices based on non-Hermitian topological dynamics by using a semiconductor platform with controllable optoelectronic properties, and towards several potential practical applications, such as on-chip optical isolators and non-reciprocal mode converters. Our results further suggest the technological relevance of non-Hermitian wave dynamics in various other branches of physics, such as acoustics, condensed-matter physics and quantum mechanics. Time-asymmetric light transmission over the entire optical communications band is achieved using a silicon photonic structure with photonic modes that dynamically encircle an exceptional point in the optical domain.
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- 2018
31. Nanophotonic identification of defects buried in three-dimensional NAND flash memory devices
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Seong Min Ma, Oh Jang Kwon, Kyu-Young Kim, Gun Pyo Kim, Yoonshik Kang, Jae Woong Yoon, Joonseong Hahn, and Seok Ho Song
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business.industry ,Computer science ,Nand flash memory ,Nanophotonics ,Physics::Optics ,Metamaterial ,Hyperspectral imaging ,02 engineering and technology ,021001 nanoscience & nanotechnology ,01 natural sciences ,Electronic, Optical and Magnetic Materials ,010309 optics ,Identification (information) ,0103 physical sciences ,Optoelectronics ,Spectral analysis ,Electrical and Electronic Engineering ,0210 nano-technology ,business ,Depth limit ,Instrumentation ,Plasmon - Abstract
Advances in nanophotonics and plasmonics have led to the creation of a variety of innovative optical components and devices. However, the development of powerful practical applications has so far been limited. Here we show that subsurface defects in three-dimensional NAND flash memory devices can be identified by exploiting the inherent hyperbolic metamaterial structure of the devices and associated nanophotonic interactions, such as the epsilon-near-zero effect and hyperbolic Bloch mode formation. By incorporating a hyperspectral imaging scheme into an industrial optical inspection tool, we experimentally demonstrate that a diffraction-assisted volume-plasmonic resonance provides a robust mechanism for identifying subsurface defects at a depth that is around ten times deeper than the conventional optical skin depth limit. Further spectral analysis in the longer-wavelength infrared region shows clear hyperbolic guided-mode-resonance signatures that would potentially allow defect identification over the entire device depth and on the scale of multiple micrometres. Deep subsurface defects in three-dimensional NAND flash memory devices can be identified by exploiting the inherent hyperbolic metamaterial structure of the devices.
- Published
- 2018
32. Sulfisoxazole Elicits Robust Antitumour Immune Response Along with Immune Checkpoint Therapy by Inhibiting Exosomal PD‐L1
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Jung Min Shin, Chan‐Hyeong Lee, Soyoung Son, Chan Ho Kim, Jae Ah Lee, Hyewon Ko, Sol Shin, Seok Ho Song, Seong‐Sik Park, Ju‐Hyun Bae, Ju‐Mi Park, Eun‐Ji Choe, Moon‐Chang Baek, and Jae Hyung Park
- Subjects
exosomal PD‐L1 ,Science ,General Chemical Engineering ,immune escape ,Immunity ,General Engineering ,General Physics and Astronomy ,Medicine (miscellaneous) ,Exosomes ,Biochemistry, Genetics and Molecular Biology (miscellaneous) ,B7-H1 Antigen ,combination therapy ,immune checkpoint therapy ,Mice ,Neoplasms ,Tumor Microenvironment ,exosome ,Animals ,Humans ,General Materials Science ,Immune Checkpoint Inhibitors ,Sulfisoxazole - Abstract
Despite their potent antitumor activity, clinical application of immune checkpoint inhibitors has been significantly limited by their poor response rates (
- Published
- 2021
33. A PEGylated hyaluronic acid conjugate for targeted cancer immunotherapy
- Author
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Suyeon Kim, Seunglee Kwon, Minchang Lee, Tae Woo Kim, V. G. Deepagan, Jung Min Shin, Hyo Jung Lee, Se Jin Oh, Jae Hyung Park, Kwon Ho Song, and Seok Ho Song
- Subjects
0301 basic medicine ,Ovalbumin ,medicine.medical_treatment ,Antigen presentation ,Mice, Nude ,Pharmaceutical Science ,Apoptosis ,Mice, Transgenic ,02 engineering and technology ,Polyethylene Glycols ,03 medical and health sciences ,Cancer immunotherapy ,Antigen ,Cell Line, Tumor ,Neoplasms ,medicine ,Animals ,Cytotoxic T cell ,Antigens ,Hyaluronic Acid ,Chemistry ,Immunotherapy ,021001 nanoscience & nanotechnology ,Mice, Inbred C57BL ,CTL ,030104 developmental biology ,Matrix Metalloproteinase 9 ,Cancer cell ,Immunology ,Cancer research ,Female ,0210 nano-technology ,T-Lymphocytes, Cytotoxic ,Conjugate - Abstract
The cell-free approach to foreignizing tumor cells with non-self antigens has received increasing attention as a method to induce cytotoxic T lymphocyte (CTL)-mediated immunological rejection of tumors, because the clinical translation of the conventional CTL-based cancer immunotherapies has been limited by a complicated manufacturing process and autotransplantation. In this study, we prepared matrix metalloproteinase 9 (MMP9)-responsive polymeric conjugates consisting of PEGylated hyaluronic acid (HA) as the targeting moiety and ovalbumin (OVA) as the model foreign antigen. The MMP9-cleavable linker was introduced between PEG and the HA backbone to facilitate the detachment of the PEG corona from the conjugate at the tumor site. From the in vitro cellular uptake study, it was revealed that the conjugate was effectively taken up by the CD44-expressing TC-1 cancer cells in the presence of MMP9 via receptor-mediated endocytosis. When the conjugate was systemically administered into the tumor-bearing mice with endogenous OVA-specific CTLs, the tumor growth was markedly inhibited, which was attributed to the significant antigen presentation on the tumor cells. Overall, the MMP9-responsive conjugates bearing foreign antigens might have the potential as an alternative to CTL-based cancer immunotherapeutics.
- Published
- 2017
34. Erratum to: Topological guided-mode resonances at non-Hermitian nanophotonic interfaces
- Author
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Youngsun Choi, Jae Woong Yoon, Seok Ho Song, Kwang Wook Yoo, Sangmo Cheon, Ki Young Lee, and Gunpyo Kim
- Subjects
Physics ,QC1-999 ,Quantum mechanics ,Mode (statistics) ,Nanophotonics ,Electrical and Electronic Engineering ,Hermitian matrix ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials ,Biotechnology - Published
- 2021
35. Extremely broadband, on-chip optical nonreciprocity enabled by mimicking nonlinear anti-adiabatic quantum jumps near exceptional points
- Author
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Pierre Berini, Youngsun Choi, Choloong Hahn, Seok Ho Song, and Jae Woong Yoon
- Subjects
Science ,General Physics and Astronomy ,Physics::Optics ,02 engineering and technology ,01 natural sciences ,General Biochemistry, Genetics and Molecular Biology ,Article ,law.invention ,Optics ,law ,0103 physical sciences ,Broadband ,Symmetry breaking ,010306 general physics ,Adiabatic process ,Quantum ,Physics ,Signal processing ,Multidisciplinary ,business.industry ,General Chemistry ,021001 nanoscience & nanotechnology ,Chip ,Laser ,Nonlinear system ,0210 nano-technology ,business - Abstract
Time-asymmetric state-evolution properties while encircling an exceptional point are presently of great interest in search of new principles for controlling atomic and optical systems. Here, we show that encircling-an-exceptional-point interactions that are essentially reciprocal in the linear interaction regime make a plausible nonlinear integrated optical device architecture highly nonreciprocal over an extremely broad spectrum. In the proposed strategy, we describe an experimentally realizable coupled-waveguide structure that supports an encircling-an-exceptional-point parametric evolution under the influence of a gain saturation nonlinearity. Using an intuitive time-dependent Hamiltonian and rigorous numerical computations, we demonstrate strictly nonreciprocal optical transmission with a forward-to-backward transmission ratio exceeding 10 dB and high forward transmission efficiency (∼100%) persisting over an extremely broad bandwidth approaching 100 THz. This predicted performance strongly encourages experimental realization of the proposed concept to establish a practical on-chip optical nonreciprocal element for ultra-short laser pulses and broadband high-density optical signal processing., Nonreciprocal optical devices can be designed based on symmetry breaking at singular points associated with non-Hermitian physics. Here, Choi et al. theoretically show that encircling of exceptional points enables the broadband operation and chip integration of such devices.
- Published
- 2017
36. All-solid-state spatial light modulator with independent phase and amplitude control for three-dimensional LiDAR applications
- Author
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Junghyun, Park, Byung Gil, Jeong, Sun Il, Kim, Duhyun, Lee, Jungwoo, Kim, Changgyun, Shin, Chang Bum, Lee, Tatsuhiro, Otsuka, Jisoo, Kyoung, Sangwook, Kim, Ki-Yeon, Yang, Yong-Young, Park, Jisan, Lee, Inoh, Hwang, Jaeduck, Jang, Seok Ho, Song, Mark L, Brongersma, Kyoungho, Ha, Sung-Woo, Hwang, Hyuck, Choo, and Byoung Lyong, Choi
- Subjects
Imaging, Three-Dimensional ,Miniaturization ,Light ,Remote Sensing Technology ,Humans ,Nanotechnology ,Optical Devices ,Equipment Design ,Automobiles ,Proof of Concept Study ,Liquid Crystals ,Nanostructures - Abstract
Spatial light modulators are essential optical elements in applications that require the ability to regulate the amplitude, phase and polarization of light, such as digital holography, optical communications and biomedical imaging. With the push towards miniaturization of optical components, static metasurfaces are used as competent alternatives. These evolved to active metasurfaces in which light-wavefront manipulation can be done in a time-dependent fashion. The active metasurfaces reported so far, however, still show incomplete phase modulation (below 360°). Here we present an all-solid-state, electrically tunable and reflective metasurface array that can generate a specific phase or a continuous sweep between 0 and 360° at an estimated rate of 5.4 MHz while independently adjusting the amplitude. The metasurface features 550 individually addressable nanoresonators in a 250 × 250 μm
- Published
- 2019
37. Metal-Phenolic Network-Coated Hyaluronic Acid Nanoparticles for pH-Responsive Drug Delivery
- Author
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Seok Ho Song, Jae Ah Lee, Jung Min Shin, Jae Hyung Park, Pil J. Yoo, Hyewon Ko, Eun Sook Lee, and Gwan H. Choi
- Subjects
Pharmaceutical Science ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Article ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,Targeted drug delivery ,Biochemistry ,pH-responsive particle ,Tannic acid ,Hyaluronic acid ,Drug delivery ,hyaluronic acid ,drug delivery ,medicine ,Doxorubicin ,Nanocarriers ,0210 nano-technology ,Cytotoxicity ,Drug carrier ,metal-phenolic network ,medicine.drug - Abstract
Although self-assembled nanoparticles (SNPs) have been used extensively for targeted drug delivery, their clinical applications have been limited since most of the drugs are released into the blood before they reach their target site. In this study, metal-phenolic network (MPN)-coated SNPs (MPN-SNPs), which consist of an amphiphilic hyaluronic acid derivative, were prepared to be a pH-responsive nanocarrier to facilitate drug release in tumor microenvironments (TME). Due to their amphiphilic nature, SNPs were capable of encapsulating doxorubicin (DOX), chosen as the model anticancer drug. Tannic acid and FeCl3 were added to the surface of the DOX-SNPs, which allowed them to be readily coated with MPNs as the diffusion barrier. The pH-sensitive MPN corona allowed for a rapid release of DOX and effective cellular SNP uptake in the mildly acidic condition (pH 6.5) mimicking TME, to which the hyaluronic acid was exposed to facilitate receptor-mediated endocytosis. The DOX-loaded MPN-SNPs exhibited a higher cytotoxicity for the cancer cells, suggesting their potential use as a drug carrier in targeted cancer therapy.
- Published
- 2019
38. Nanofabrication of plasmonic structures on insulating substrates by resist-on-metal bilayer lift-off
- Author
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Pierre Berini, Youngsun Choi, Seok Ho Song, Maryam Al-Shehab, Choloong Hahn, Howard Northfield, Maude Amyot-Bourgeois, and R. Niall Tait
- Subjects
Materials science ,Physics::Optics ,Bioengineering ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,law.invention ,law ,General Materials Science ,Electrical and Electronic Engineering ,Lithography ,Plasmon ,business.industry ,Mechanical Engineering ,Bilayer ,Metamaterial ,General Chemistry ,021001 nanoscience & nanotechnology ,Computer Science::Other ,0104 chemical sciences ,Nanolithography ,Resist ,Mechanics of Materials ,Optoelectronics ,Photolithography ,0210 nano-technology ,business ,Electron-beam lithography - Abstract
In last few decades, micro- and nano-fabrication techniques based on photolithography and electron beam lithography have advanced greatly, mainly in the field of semiconductor fabrication. Such techniques are generally transferrable to the fabrication of plasmonic structures and metamaterials. However, plasmonic devices often require a transparent insulating substrate to be operational at visible or near-infrared wavelengths. Here we report a resist-on-metal bilayer lift-off technique enabling the fabrication of plasmonic structures on insulating substrates. The metal layer under the resist eliminates major difficulties in lithography, such as charging during electron beam exposure and uncontrolled diffuse optical scattering during photolithography. In addition, the resist-on-metal bilayer can be migrated to different substrates with minimal process alteration, because the material properties of the substrate, such as secondary electron emission or optical reflectance, become irrelevant due to the shielding provided by the metal layer. As demonstrations, we fabricate large-scale plasmonic waveguides and Bragg gratings, adiabatically-modulated plasmonic waveguide couplers, and plasmonic nanoantenna arrays using the resist-on-metal bilayer lift-off process. The process can also be used to define structures formed of other materials such as dielectrics.
- Published
- 2018
39. Unidirectional Bragg Gratings Using Parity-Time Symmetry Breaking in Plasmonic Systems
- Author
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Pierre Berini, Cha-Hwan Oh, Elham Karami Keshmarzi, R. Niall Tait, Choloong Hahn, and Seok Ho Song
- Subjects
Physics ,business.industry ,Computation ,Physics::Optics ,Parity (physics) ,01 natural sciences ,Surface plasmon polariton ,Atomic and Molecular Physics, and Optics ,010309 optics ,Optics ,Modal ,0103 physical sciences ,Group velocity ,Optoelectronics ,Symmetry breaking ,Electrical and Electronic Engineering ,010306 general physics ,business ,Refractive index ,Plasmon - Abstract
Optical systems following concepts of parity-time (PT) symmetry have attracted significant attention because of their extraordinary behavior such as unidirectional reflectance or power oscillation. PT symmetric optical systems are realized by judiciously manipulating the complex refractive index to produce even- and odd-symmetric distributions for the real and imaginary indices, respectively. We propose two PT symmetric Bragg gratings based on step-in-width metal stripes and dielectric-loaded metal stripes operating with long-range surface plasmon polaritons. The gratings are designed to operate near 880 nm because optical gain can be conveniently provided by IR140-doped PMMA. Asymmetric reflectance is predicted in the proposed gratings based on modal and transfer matrix method computations. Moreover, we analyzed pulse reshaping and energy transport in generic gratings, and in the proposed plasmonic gratings, in terms of group and energy velocities. It is found that the group and energy velocities are dispersionless at the PT symmetry breaking point. Also, the group velocity dispersion can be inverted by changing the PT symmetric state from broken to unbroken or vice versa. Our designs are practical because a large left-right asymmetric reflectance contrast is produced for a wide range of physical dimensions. The proposed gratings are suitable as on-chip devices for optical processing providing new functionality such as switching and controlling the time delay of a data pulse without distortion.
- Published
- 2016
40. A deep subwavelength cavity formed by total external reflection of surface plasmon polariton.
- Author
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Kang Hee Seol, Kwang-Geol Lee, and Seok Ho Song
- Subjects
SURFACE plasmons ,PLASMONICS ,PERMITTIVITY ,METALLIC surfaces ,NANOPHOTONICS - Abstract
We numerically analyze the characteristics of a nanocavity in surface plasmon polariton (SPP) modes confined by total external reflection (TER) at deep subwavelength scales. This SPP-TER cavity consists of a low-index dielectric channel on a flat metal surface covered by a high-index gain medium. Compared to other types of nanocavities formed by total internal reflection such as a metallic channel and a high-index dielectric channel, an SPP-TER nanocavity provides superior functionality on mode area, confinement factor in the gain medium, Q-factor, and threshold gain. From this result, we suggest the SPP-TER nanocavity as a promising high-quality deep-subwavelength scale resonator, which is an essential ingredient in nanophotonics. [ABSTRACT FROM AUTHOR]
- Published
- 2015
- Full Text
- View/download PDF
41. Quantum plasmonic sensing using single photons
- Author
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Seung Jin Yoon, Carsten Rockstuhl, Joong Sung Lee, Seok Ho Song, Hyungju Rah, Kwang-Geol Lee, Mark Tame, and Changhyoup Lee
- Subjects
Physics ,Quantum Physics ,Photon ,business.industry ,FOS: Physical sciences ,Physics::Optics ,02 engineering and technology ,021001 nanoscience & nanotechnology ,01 natural sciences ,Noise (electronics) ,Atomic and Molecular Physics, and Optics ,Quantum technology ,Attenuated total reflection ,0103 physical sciences ,Limit (music) ,Optoelectronics ,010306 general physics ,0210 nano-technology ,business ,Quantum Physics (quant-ph) ,Refractive index ,Quantum ,Plasmon ,Optics (physics.optics) ,Physics - Optics - Abstract
Reducing the noise below the shot-noise limit in sensing devices is one of the key promises of quantum technologies. Here, we study quantum plasmonic sensing based on an attenuated total reflection configuration with single photons as input. Our sensor is the Kretschmann configuration with a gold film, and a blood protein in an aqueous solution with different concentrations serves as an analyte. The estimation of the refractive index is performed using heralded single photons. We also determine the estimation error from a statistical analysis over a number of repetitions of identical and independent experiments. We show that the errors of our plasmonic sensor with single photons are below the shot-noise limit even in the presence of various experimental imperfections. Our results demonstrate a practical application of quantum plasmonic sensing is possible given certain improvements are made to the setup investigated, and pave the way for a future generation of quantum plasmonic applications based on similar techniques., 11 pages, 3 figures
- Published
- 2018
42. Observation of an anti-PT-symmetric exceptional point and energy-difference conserving dynamics in electrical circuit resonators
- Author
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Jae Woong Yoon, Choloong Hahn, Seok Ho Song, and Youngsun Choi
- Subjects
Physics ,Multidisciplinary ,Science ,Physical system ,General Physics and Astronomy ,Inverse ,02 engineering and technology ,General Chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Hermitian matrix ,General Biochemistry, Genetics and Molecular Biology ,Symmetry (physics) ,Article ,law.invention ,Resonator ,law ,Quantum mechanics ,Electrical network ,0103 physical sciences ,010306 general physics ,0210 nano-technology ,Constant (mathematics) ,Energy (signal processing) - Abstract
Parity-time (PT) symmetry and associated non-Hermitian properties in open physical systems have been intensively studied in search of new interaction schemes and their applications. Here, we experimentally demonstrate an electrical circuit producing key non-Hermitian properties and unusual wave dynamics grounded on anti-PT (APT) symmetry. Using a resistively coupled amplifying-LRC-resonator circuit, we realize a generic APT-symmetric system that enables comprehensive spectral and time-domain analyses on essential consequences of the APT symmetry. We observe an APT-symmetric exceptional point (EP), inverse PT-symmetry breaking transition, and counterintuitive energy-difference conserving dynamics in stark contrast to the standard Hermitian dynamics keeping the system’s total energy constant. Therefore, we experimentally confirm unique properties of APT-symmetric systems, and further development in other areas of physics may provide new wave-manipulation techniques and innovative device-operation principles., The study of parity-time (PT) symmetric optical systems has recently attracted much attention. Here, the authors experimentally study an anti-PT symmetric circuit system and observe an exceptional point with an inverse PT symmetry breaking transition and energy-difference conserving dynamics.
- Published
- 2018
43. A carboxymethyl dextran-based polymeric conjugate as the antigen carrier for cancer immunotherapy
- Author
-
Seok Ho Song, N. Vijayakameswara Rao, Jung Min Shin, Eun Sook Lee, Hyewon Ko, and Jae Hyung Park
- Subjects
0301 basic medicine ,lcsh:Medical technology ,medicine.medical_treatment ,Antigen presentation ,Antigen delivery ,Biomedical Engineering ,Medicine (miscellaneous) ,Cancer immunotherapy ,02 engineering and technology ,Carboxymethyl dextran ,Major histocompatibility complex ,Biomaterials ,03 medical and health sciences ,Antigen ,medicine ,Cytotoxic T cell ,biology ,Chemistry ,021001 nanoscience & nanotechnology ,Ovalbumin ,030104 developmental biology ,lcsh:R855-855.5 ,Cancer cell ,Ceramics and Composites ,Cancer research ,biology.protein ,0210 nano-technology ,Conjugate ,Research Article - Abstract
Background Antigen-specific cytotoxic T lymphocytes (CTLs), which eliminate target cells bearing antigenic peptides presented by surface major histocompatibility complex (MHC) class I molecules, play a key role in cancer immunotherapy. However, the majority of tumors are not immunologically rejected since they express self-antigens which are not recognized by CTLs as foreign. To foreignize these tumors for CTL-mediated immunological rejection, it is essential to develop carriers that can effectively deliver foreign antigens to cancer cells. Methods A polymeric conjugate, composed of a carboxymethyl dextran (CMD) as the backbone and ovalbumin (OVA) as a model foreign antigen, was prepared to investigate its potential as the antigen carrier for cancer immunotherapy. Results An in vitro cellular uptake study showed that the conjugate was successfully taken up by TC-1 cervical cancer cells. When CMD-OVA was systemically administered to tumor-bearing mice, the strong fluorescence signal was observed at the tumor site over the whole period of time period, suggesting high tumor targetability of the conjugate. Compared to free OVA, CMD-OVA induced significantly higher antigen presentation at the tumor site. Conclusions The CMD-OVA conjugate can effectively deliver the antigen to the tumor site, implying its high potential as the antigen carrier for cancer immunotherapy.
- Published
- 2018
44. Wideband ominidirectional reflectors and polarizers with minimal material embodiment (Conference Presentation)
- Author
-
Robert Magnusson, Jae Woong Yoon, Gunpyo Kim, and Seok Ho Song
- Subjects
Physics ,Diffraction ,business.industry ,Terahertz radiation ,Physics::Optics ,Polarizer ,law.invention ,Optics ,law ,Broadband ,Reflection (physics) ,Photonics ,Wideband ,business ,Omnidirectional antenna - Abstract
We theoretically suggest ultra-sparse 1D and 2D arrays of high-index dielectric wires as broadband, omnidirectional reflectors and polarizers. Using diffraction potential arguments and numerical simulations, we show the proposed device for 1D array supports a high-extinction polarizing function. For an optimized 1D SrTiO3-wire array, a TE reflection resonance has a remarkably wide bandwidth while the TM wave almost freely passes through the array in the entire zero-order spectral domain. Based on the theoretically observed performance of the 1D array, we design fully conical omnidirectionality in the reflection for the 2D extension at the center wavelength of the fundamental-mode resonance condition. We briefly discuss possibility of the proposed 1D and 2D wire grid architectures for space-variant beam transforming optics and vector beam generations. Applications to THz photonic components and other long-wave devices such as radio-wave telescopes and satellite antenna are envisioned.
- Published
- 2018
45. Experimental demonstration of a broadband time-asymmetric waveguide architecture enabled by dynamically encircling an exceptional point in the optical domain (Conference Presentation)
- Author
-
Jong Kyun Hong, Yeonghwa Ryu, Gunpyo Kim, Ki Yeon Yang, Pierre Berini, Youngsun Choi, Choloong Hahn, Jeong Yub Lee, Jae Woong Yoon, and Seok Ho Song
- Subjects
Physics ,Spectrum analyzer ,Optics ,Silicon photonics ,Transmission (telecommunications) ,business.industry ,Broadband ,Phase (waves) ,Physics::Optics ,Photonics ,Infrared microscopy ,business ,Waveguide (optics) - Abstract
We experimentally demonstrate a robust Si-photonic waveguide architecture that realizes dynamically encircling an exceptional point (EP) in the optical domain and broadband asymmetric modal transmission as an essential consequence. The structure consists of a pair of coupled channel waveguides and an adjacent slab-waveguide patch that enable precise lithographic controls on the phase velocities and radiation rates of the guided photonic modes. Complex modal index and inter-mode coupling constant profiles required for the encircling-an-EP parametric control are precisely coded in the geometry of those elements. The device created on this basis induces the symmetry-exchanging adiabatic state flip for one transmission direction and symmetry-preserving anti-adiabatic state-jump for the transmission in the opposite direction. In fabrication, we use a state-of-the-art electron-beam lithography for creating mm-long devices with nm-scale transversal precision. A comprehensive spectral measurement for the intensity and phase distributions of the transmitted optical states is obtained with a specially designed phase-sensitive infrared microscopy integrated with a tunable diode-laser system and spectrum analyzer. On this basis, we confirm in the experiment the highly asymmetric modal transmission persisting over a broad spectral band exceeding 100 nm in the telecommunications window around 1,550 nm. Hence, we establish a substantive experimental step toward broadband non-reciprocal photonic devices based on the unique non-Hermitian dynamics.
- Published
- 2018
46. Non-Hermitian dynamics of light near exceptional points
- Author
-
Seok Ho Song, Jae Woong Yoon, Pierre Berini, and Youngsun Choi
- Subjects
Physics ,Resonator ,Optics ,Transmission (telecommunications) ,Exceptional point ,Wave propagation ,business.industry ,Dynamics (mechanics) ,Broadband ,Physics::Optics ,business ,Hermitian matrix - Abstract
The non-Hermitian concepts, including PT symmetry-breaking, of judiciously utilizing both optical gain and loss in metaphotonic structures have recently emerged as a new paradigm to control the propagation of light. We present experimental realizations of non-Hermitian dynamics near exceptional points (EPs) both in electric resonators and silicon-photonic waveguides that create dynamically encircling an EP and consequent time-asymmetric transmission of broadband signals.
- Published
- 2018
47. Experimental observation of a practical limit on enhancement of the spontaneous emission rate in blue GaN-LEDs by mediating surface plasmons
- Author
-
Kwang-Geol Lee, Ki-Young Choi, and Seok Ho Song
- Subjects
Materials science ,business.industry ,Surface plasmon ,Optical communication ,General Physics and Astronomy ,law.invention ,Modulation ,Etching (microfabrication) ,law ,Optoelectronics ,General Materials Science ,Spontaneous emission ,business ,Layer (electronics) ,Diode ,Light-emitting diode - Abstract
High modulation speed of light-emitting diodes (LEDs) is of primary importance for applications in optical communication. To this end, we experimentally investigated enhancement behaviors of the spontaneous emission rate (SER) of electron–hole pairs in blue InGaN/GaN LEDs by mediating surface plasmons (SPs). The coupling strength of the electron–hole recombination into SPs is controlled by etching the p-GaN layer between the active and metal layers to form thicknesses between 40 nm and 10 nm. While a tendency of increasing SER is theoretically expected for a smaller separation, the maximum value SER enhancement has a practical limit of about 2.5 at λ = 441 nm, and separation of 20 nm due to damage on the p-GaN layer caused by the etching process.
- Published
- 2014
48. Optimal design of green InGaN/GaN LEDs mediated by surface-plasmon gratings
- Author
-
Seok Ho Song, Kwang-Geol Lee, and Ki-Young Choi
- Subjects
Optimal design ,Coupling ,Materials science ,business.industry ,Surface plasmon ,General Physics and Astronomy ,Radiation ,law.invention ,law ,Optoelectronics ,General Materials Science ,Spontaneous emission ,Quantum efficiency ,business ,Quantum well ,Light-emitting diode - Abstract
We propose an optimal design for enhancing the external quantum efficiency of InGaN/GaN LEDs operating in the green spectral region, by mediating surface plasmons (SP), showing that there is plenty of potential for additional improvement in this area. Coupling the spontaneous emission from quantum wells into SP modes on metallic grating structures could enhance the internal quantum efficiency of conventional LEDs by more than twofold, and the relatively long propagating length of SPs in the green region could allow a narrow radiating angle and thus yield a threefold improvement in the extraction efficiency of radiation. Thus, our design enhances external quantum efficiency by about sixfold overall, offering a practically attainable method to realize highly efficient green SP-LEDs.
- Published
- 2014
49. Electrically tunable binary phase Fresnel lens based on a dielectric elastomer actuator
- Author
-
Seok Ho Song, Bong Je Park, Suntak Park, Ki-Uk Kyung, Seung Koo Park, Jeong-Mook Lim, Saekwang Nam, Seongcheol Mun, Sungryul Yun, and Yeonghwa Ryu
- Subjects
Materials science ,Fresnel zone ,business.industry ,Phase (waves) ,Fresnel lens ,02 engineering and technology ,Dielectric ,Zone plate ,021001 nanoscience & nanotechnology ,01 natural sciences ,Atomic and Molecular Physics, and Optics ,law.invention ,010309 optics ,Lens (optics) ,Optics ,law ,0103 physical sciences ,Focal length ,0210 nano-technology ,business ,Actuator - Abstract
We propose and demonstrate an all-solid-state tunable binary phase Fresnel lens with electrically controllable focal length. The lens is composed of a binary phase Fresnel zone plate, a circular acrylic frame, and a dielectric elastomer (DE) actuator which is made of a thin DE layer and two compliant electrodes using silver nanowires. Under electric potential, the actuator produces in-plane deformation in a radial direction that can compress the Fresnel zones. The electrically-induced deformation compresses the Fresnel zones to be contracted as high as 9.1% and changes the focal length, getting shorter from 20.0 cm to 14.5 cm. The measured change in the focal length of the fabricated lens is consistent with the result estimated from numerical simulation.
- Published
- 2017
50. Time-asymmetric loop around an exceptional point over the full optical communications band
- Author
-
Jae Woong, Yoon, Youngsun, Choi, Choloong, Hahn, Gunpyo, Kim, Seok Ho, Song, Ki-Yeon, Yang, Jeong Yub, Lee, Yongsung, Kim, Chang Seung, Lee, Jai Kwang, Shin, Hong-Seok, Lee, and Pierre, Berini
- Abstract
Topological operations around exceptional points
- Published
- 2017
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