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23 results on '"Seo, Y. David"'

7. Data from Neoadjuvant Therapy Induces a Potent Immune Response to Sarcoma, Dominated by Myeloid and B Cells

Author

Goff, Peter H., primary, Riolobos, Laura, primary, LaFleur, Bonnie J., primary, Spraker, Matthew B., primary, Seo, Y. David, primary, Smythe, Kimberly S., primary, Campbell, Jean S., primary, Pierce, Robert H., primary, Zhang, Yuzheng, primary, He, Qianchuan, primary, Kim, Edward Y., primary, Schaub, Stephanie K., primary, Kane, Gabrielle M., primary, Mantilla, Jose G., primary, Chen, Eleanor Y., primary, Ricciotti, Robert, primary, Thompson, Matthew J., primary, Cranmer, Lee D., primary, Wagner, Michael J., primary, Loggers, Elizabeth T., primary, Jones, Robin L., primary, Murphy, Erin, primary, Blumenschein, Wendy M., primary, McClanahan, Terrill K., primary, Earls, Jon, primary, Flanagan, Kevin C., primary, LaFranzo, Natalie A., primary, Kim, Teresa S., primary, and Pollack, Seth M., primary

Published
2023
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8. Supplementary Figure from Neoadjuvant Therapy Induces a Potent Immune Response to Sarcoma, Dominated by Myeloid and B Cells

Author

Goff, Peter H., primary, Riolobos, Laura, primary, LaFleur, Bonnie J., primary, Spraker, Matthew B., primary, Seo, Y. David, primary, Smythe, Kimberly S., primary, Campbell, Jean S., primary, Pierce, Robert H., primary, Zhang, Yuzheng, primary, He, Qianchuan, primary, Kim, Edward Y., primary, Schaub, Stephanie K., primary, Kane, Gabrielle M., primary, Mantilla, Jose G., primary, Chen, Eleanor Y., primary, Ricciotti, Robert, primary, Thompson, Matthew J., primary, Cranmer, Lee D., primary, Wagner, Michael J., primary, Loggers, Elizabeth T., primary, Jones, Robin L., primary, Murphy, Erin, primary, Blumenschein, Wendy M., primary, McClanahan, Terrill K., primary, Earls, Jon, primary, Flanagan, Kevin C., primary, LaFranzo, Natalie A., primary, Kim, Teresa S., primary, and Pollack, Seth M., primary

Published
2023
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9. Supplementary Data from Neoadjuvant Therapy Induces a Potent Immune Response to Sarcoma, Dominated by Myeloid and B Cells

Author

Goff, Peter H., primary, Riolobos, Laura, primary, LaFleur, Bonnie J., primary, Spraker, Matthew B., primary, Seo, Y. David, primary, Smythe, Kimberly S., primary, Campbell, Jean S., primary, Pierce, Robert H., primary, Zhang, Yuzheng, primary, He, Qianchuan, primary, Kim, Edward Y., primary, Schaub, Stephanie K., primary, Kane, Gabrielle M., primary, Mantilla, Jose G., primary, Chen, Eleanor Y., primary, Ricciotti, Robert, primary, Thompson, Matthew J., primary, Cranmer, Lee D., primary, Wagner, Michael J., primary, Loggers, Elizabeth T., primary, Jones, Robin L., primary, Murphy, Erin, primary, Blumenschein, Wendy M., primary, McClanahan, Terrill K., primary, Earls, Jon, primary, Flanagan, Kevin C., primary, LaFranzo, Natalie A., primary, Kim, Teresa S., primary, and Pollack, Seth M., primary

Published
2023
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12. T‐cell infiltration and clonality correlate with programmed cell death protein 1 and programmed death‐ligand 1 expression in patients with soft tissue sarcomas

Author

Pollack, Seth M., He, Qianchuan, Yearley, Jennifer H., Emerson, Ryan, Vignali, Marissa, Zhang, Yuzheng, Redman, Mary W., Baker, Kelsey K., Cooper, Sara, Donahue, Bailey, Loggers, Elizabeth T., Cranmer, Lee D., Spraker, Matthew B., Seo, Y. David, Pillarisetty, Venu G., Ricciotti, Robert W., Hoch, Benjamin L., McClanahan, Terrill K., Murphy, Erin, Blumenschein, Wendy M., Townson, Steven M., Benzeno, Sharon, Riddell, Stanley R., and Jones, Robin L.

Published
2017
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13. Blockade of interleukin 10 potentiates antitumour immune function in human colorectal cancer liver metastases

Author

Sullivan, Kevin M, primary, Jiang, Xiuyun, additional, Guha, Prajna, additional, Lausted, Christopher, additional, Carter, Jason A, additional, Hsu, Cynthia, additional, Labadie, Kevin P, additional, Kohli, Karan, additional, Kenerson, Heidi L, additional, Daniel, Sara K, additional, Yan, Xiaowei, additional, Meng, Changting, additional, Abbasi, Arezou, additional, Chan, Marina, additional, Seo, Y David, additional, Park, James O, additional, Crispe, Ian Nicholas, additional, Yeung, Raymond S, additional, Kim, Teresa S, additional, Gujral, Taranjit S, additional, Tian, Qiang, additional, Katz, Steven C, additional, and Pillarisetty, Venu G, additional

Published
2022
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15. Neoadjuvant Therapy Induces a Potent Immune Response to Sarcoma, Dominated by Myeloid and B Cells

Author

Goff, Peter H., primary, Riolobos, Laura, additional, LaFleur, Bonnie J., additional, Spraker, Matthew B., additional, Seo, Y. David, additional, Smythe, Kimberly S., additional, Campbell, Jean S., additional, Pierce, Robert H., additional, Zhang, Yuzheng, additional, He, Qianchuan, additional, Kim, Edward Y., additional, Schaub, Stephanie K., additional, Kane, Gabrielle M., additional, Mantilla, Jose G., additional, Chen, Eleanor Y., additional, Ricciotti, Robert, additional, Thompson, Matthew J., additional, Cranmer, Lee D., additional, Wagner, Michael J., additional, Loggers, Elizabeth T., additional, Jones, Robin L., additional, Murphy, Erin, additional, Blumenschein, Wendy M., additional, McClanahan, Terrill K., additional, Earls, Jon, additional, Flanagan, Kevin C., additional, LaFranzo, Natalie A., additional, Kim, Teresa S., additional, and Pollack, Seth M., additional

Published
2022
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16. Blockade of interleukin 10 potentiates antitumour immune function in human colorectal cancer liver metastases.

Author

Sullivan, Kevin M., Jiang, Xiuyun, Guha, Prajna, Lausted, Christopher, Carter, Jason A., Hsu, Cynthia, Labadie, Kevin P., Kohli, Karan, Kenerson, Heidi L., Daniel, Sara K., Yan, Xiaowei, Meng, Changting, Abbasi, Arezou, Chan, Marina, Seo, Y. David, Park, James O., Crispe, Ian Nicholas, Yeung, Raymond S., Kim, Teresa S., and Gujral, Taranjit S.

Subjects
COLORECTAL liver metastasis, MYELOID-derived suppressor cells, CYTOTOXIC T cells, T helper cells, REGULATORY T cells, RECTAL cancer
Published
2023
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17. VirMAP for Cancer: Characterization of the Intratumoral Virome in Virally-Associated Cancers and a Resource for Investigators

Author

Seo, Y David, primary, Bhutiani, Neal, additional, Wong, Matthew, additional, Lastrapes, Matthew, additional, Lazar, Alexander, additional, McAllistar, Florencia, additional, Colbert, Lauren, additional, Klopp, Ann H., additional, Ferguson, Sherise D., additional, Lang, Frederick, additional, Wargo, Jennifer, additional, and Ajami, Nadim, additional

Published
2022
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19. Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice

Author

Mukherjee, Siddhartha, Raje, Noopur, Schoonmaker, Jesse A., Liu, Julie C., Hideshima, Teru, Wein, Marc N., Jones, Dallas C., Vallet, Sonia, Bouxsein, Mary L., Pozzi, Samantha, Chhetri, Shweta, Seo, Y. David, Aronson, Joshua P., Patel, Chirayu, Fulciniti, Mariateresa, Purton, Louise E., Glimcher, Laurie H., Lian, Jane B., Stein, Gary, Anderson, Kenneth C., and Scadden, David T.

Subjects
Bone regeneration -- Physiological aspects, Bone regeneration -- Methods, Bone regeneration -- Research, Pharmacology, Experimental -- Methods
Abstract

Drug targeting of adult stem cells has been proposed as a strategy for regenerative medicine, but very few drugs are known to target stem cell populations in vivo. Mesenchymal stem/progenitor cells (MSCs) are a multipotent population of cells that can differentiate into muscle, bone, fat, and other cell types in context-specific manners. Bortezomib (Bzb) is a clinically available proteasome inhibitor used in the treatment of multiple myeloma. Here, we show that Bzb induces MSCs to preferentially undergo osteoblastic differentiation, in part by modulation of the bone-specifying transcription factor runt-related transcription factor 2 (Runx-2) in mice. Mice implanted with MSCs showed increased ectopic ossicle and bone formation when recipients received low doses of Bzb. Furthermore, this treatment increased bone formation and rescued bone loss in a mouse model of osteoporosis. Thus, we show that a tissue-resident adult stem cell population in vivo can be pharmacologically modified to promote a regenerative function in adult animals., Introduction Multipotent bone marrow stromal cells capable of giving rise to osteoblasts, adipocytes, and chondrocytes (a population termed mesenchymal stem/progenitor cells [MSCs]) were originally described by Friedenstein in 1966 (1), [...]

Published
2008

21. Abstract LB-190: Single-cell polyfunctionality of circulating CD4+ T cells correlates with T cell receptor repertoire diversity of PBMCs, indicating potential synergistic activity and peripheral biomarker predictive of efficacy of intratumor injection of the toll-like receptor 4 agonist G100

Author

Mackay, Sean, primary, Chen, Jon, additional, Patino, Jeremy, additional, Seo, Y. David, additional, Pollack, Seth, additional, and Zhou, Jing, additional

Published
2019
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23. Establishment of Slice Cultures as a Tool to Study the Cancer Immune Microenvironment.

Author

Jiang X, Seo YD, Sullivan KM, and Pillarisetty VG

Subjects
Biopsy, Carcinoma, Pancreatic Ductal immunology, Carcinoma, Pancreatic Ductal pathology, Carcinoma, Pancreatic Ductal therapy, Coculture Techniques instrumentation, Coculture Techniques methods, Fluorescent Dyes chemistry, Humans, Immunotherapy methods, Microscopy, Fluorescence instrumentation, Microscopy, Fluorescence methods, Pancreas immunology, Pancreas pathology, Pancreatic Neoplasms immunology, Pancreatic Neoplasms pathology, Pancreatic Neoplasms therapy, Spleen immunology, Spleen pathology, Staining and Labeling instrumentation, Tissue Culture Techniques instrumentation, Treatment Outcome, Staining and Labeling methods, Tissue Culture Techniques methods, Tumor Microenvironment immunology
Abstract

Although immunotherapy is currently being widely applied to treat a variety of cancers, there is great heterogeneity in the response to these treatments. Many in the field hypothesize that this may be attributable to the characteristics of each individual tumor immune microenvironment, in addition to systemic immune factors. Therefore, understanding the immune cell microenvironment in a variety of tumors is critically important. Specifically, the interactions among immune, stromal, and cancer cells, along with other factors in tumors, may hold the key to developing rational personalized combinations of immunotherapeutic drugs. We recently developed an organotypic slice culture technique, which enables precise study of the pancreatic ductal adenocarcinoma (PDA) tumor microenvironment. We used a Vibratome to cut fresh human tumor tissue into 250 μm thick slices, and cultured slices on cell culture inserts with 0.4 μm pore to produce our tumor slice culture (TSC) system. We showed that TSC maintained many elements of the original tumor microenvironment and architecture for approximately one week. Using this slice culture technique for PDA, we demonstrated that immune cells, including T cells and macrophages, cancer cells, and stromal myofibroblasts were present throughout the culture period. TSCs were functionally responsive to drug treatment. Live PDA slices could be stained for multicolor immunofluorescence imaging of each of the primary cellular constituents of the tumor. Finally, autologous CFSE-labeled splenocytes were observed to readily migrate into cocultured tumor slices.

Published
2019
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