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Your search keyword '"Seo, Ji-Won"' showing total 424 results
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424 results on '"Seo, Ji-Won"'

4. Evaluation of left ventricular filling pressure by echocardiography in patients with atrial fibrillation

Author

Khan, Faraz H., Zhao, Debbie, Ha, Jong-Won, Nagueh, Sherif F., Voigt, Jens-Uwe, Klein, Allan L., Gude, Einar, Broch, Kaspar, Chan, Nicholas, Quill, Gina M., Doughty, Robert N., Young, Alistair, Seo, Ji-Won, García-Izquierdo, Eusebio, Moñivas-Palomero, Vanessa, Mingo-Santos, Susana, Wang, Tom Kai Ming, Bezy, Stephanie, Ohte, Nobuyuki, Skulstad, Helge, Beladan, Carmen C., Popescu, Bogdan A., Kikuchi, Shohei, Panis, Vasileios, Donal, Erwan, Remme, Espen W., Nash, Martyn P., and Smiseth, Otto A.

Published
2024
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21. IL-32γ Induced Autophagy Through Suppression of MET and mTOR Pathways in Liver Tumor Growth Inhibition.

Author

Seo, Ji-Won, Lee, Yong-Sun, Jeon, In-Sook, Yu, Ji-Eun, Yoo, Jun-Sang, Koo, Ja-Keun, Son, Dong-Ju, Yoon, Jae-Suk, Han, Sang-Bae, Yoon, Do-Young, Roh, Yoon-Seok, Hong, Jin-Tae, and Shim, Jung-Hyun

Subjects
*MTOR protein, *LIVER tumors, *CELL cycle, *TUMOR growth, *LIVER cancer
Abstract

Interleukin-32γ (IL-32γ) has diverse functions in various malignancies. In this study, we investigated the role of IL-32γ in autophagy induction in liver cancer cells and delineated the underlying mechanisms. We found that the increased IL-32γ expression inhibited the growth, cell cycle progression, and migration of HepG2 and Hep3B cell lines; it also decreased the expression of related proteins. Furthermore, the IL-32γ overexpression induced autophagy, as indicated by the number of puncta, the expression of LC3, and the expression of autophagy-related markers. The expression levels of LAMP1, a protein essential for autophagosome formation, and colocalization with LC3 also increased. Big data analysis revealed that the expression of MET, a well-known target of autophagy, and the expression of mTOR and mTOR-related proteins were decreased by the IL-32γ overexpression. The combination treatment of MET inhibitor, cabozantinib (2 µM), and IL-32γ overexpression further increased the number of puncta, the colocalization of LC3 and LAMP1, and the expression of autophagy-related proteins. In vivo, liver tumor growth was suppressed in the IL-32γ-overexpressing mouse model, and autophagy induction was confirmed by the increased expression of LC3 and LAMP1 and the decreased expression of autophagy pathway markers (MET and mTOR). Autophagy was also decreased in the liver tumor sample of human patients. ROC curve and spearman analysis revealed that the expression levels of LC3 and IL-32γ were significantly correlated in human tumor serum and tissues. Therefore, IL-32γ overexpression induced autophagy in liver tumors through the suppression of MET and mTOR pathways critical for tumor growth inhibition. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Clinical characteristics of persistent postural‐perceptual dizziness and its visual subtype in Korean patients: A multicenter cross‐sectional study

Author

Park, Joo Hyun, primary, Nguyen, Thanh Tin, additional, Kim, Sung‐Hee, additional, Park, Ji‐Yun, additional, Na, Seunghee, additional, Jeon, Eun‐Ju, additional, Seo, Ji won, additional, Cho, Chang Gun, additional, Oh, Se‐Joon, additional, Choi, Sung‐Won, additional, Choi, Kwang‐Dong, additional, Choi, Seo‐Young, additional, Choi, Ji Eun, additional, Hong, Sung‐Kwang, additional, Chung, Won‐Ho, additional, Cho, Young Sang, additional, Lee, Hwan Ho, additional, An, Yong‐Hwi, additional, Han, Kyu‐Hee, additional, Lee, Hyung, additional, Kim, Hyun Ah, additional, Lee, Ho Yun, additional, Lee, Jong‐Dae, additional, Lee, Se A, additional, and Oh, Sun‐Young, additional

Published
2024
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42. Phase formation and superconducting properties of (Tl,M)(Sr, Ba)Ca3Cu4Oz compounds with M = Ca, Mg, and Cu.

Author

Lee, Ho Keun, Park, Sangmin, Seo, Ji Won, and Abd-Shukor, Roslan

Abstract

Polycrystalline samples of (Tl1−xMx)SrBaCa3Cu4Oz ((Tl, M)-1234), where M = Ca, Mg and Cu, were prepared by using a solid state reaction method to find the environmentally friendly element that promotes the formation of the 1234 phase. X-ray diffraction data showed that Ca substitution was very effective in forming the 1234 phase at normal pressure, compared to either Mg or Cu substitution. Nearly single-phase samples were obtained for the nominal compositions of (Tl1−xCax)SrBaCa3Cu4Oz (0.3 ≤ x ≤ 0.5) and (Tl0.7Ca0.3)(Sr2−yBay)Ca3Cu4Oz (1.0 ≤ y ≤ 1.25). The (Tl0.7Ca0.3)(Sr2−yBay)Ca3Cu4Oz (1.0 ≤ y ≤ 1.25) samples were found to have a relatively homogeneous microstructure by scanning electron micrography. Bulk superconductivity with Tc of 102 K was observed in the (Tl0.7Ca0.3)SrBaCa3Cu4Oz sample. The experimental results suggest that Ca can be a very useful element in the charge reservoir layer to form a single-phase Tl-1234-type compound with appropriate substitution of Ba into the Sr sites in the bridging layer. [ABSTRACT FROM AUTHOR]

Published
2024
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