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22. Allergy immunotherapy across the life cycle to promote active and healthy ageing : from research to policies

Author

Calderon, M. A., Demoly, P., Casale, T., Akdis, C. A., Bachert, C., Bewick, M., Bilo, B. M., Bohle, B., Bonini, S., Bush, A., Caimmi, D. P., Canonica, G. W., Cardona, V., Chiriac, A. M., Cox, L., Custovic, A., De Blay, F., Devillier, P., Didier, A., Di Lorenzo, G., Du Toit, G., Durham, S. R., Eng, P., Fiocchi, A., Fox, A. T., van Wijk, R. Gerth, Gomez, R. M., Haahtela, Tari Markku Kallevi, Halken, S., Hellings, P. W., Jacobsen, L., Just, J., Tanno, L. K., Kleine-Tebbe, J., Klimek, L., Knol, E. F., Kuna, P., Larenas-Linnemann, D. E., Linneberg, A., Matricardi, M., Malling, H. J., Moesges, R., Mullol, J., Muraro, A., Papadopoulos, N., Passalacqua, G., Pastorello, E., Pfaar, O., Price, D., Rodriguez del Rio, P., Rueff, R., Samolinski, B., Scadding, G. K., Senti, G., Shamji, M. H., Sheikh, A., Sisul, J. C., Sole, D., Sturm, G. J., Tabar, A., Van Ree, R., Ventura, M. T., Vidal, C., Varga, E. M., Worm, M., Zuberbier, T., Bousquet, J., Clinicum, and Department of Dermatology, Allergology and Venereology

Subjects
EIP on AHA, EAACI POSITION PAPER, RUSH IMMUNOTHERAPY, GRASS-POLLEN ALLERGY, INTERNATIONAL CONSENSUS, EUROPEAN INNOVATION PARTNERSHIP, NATIONAL DATABASES, ORAL IMMUNOTHERAPY, Asthma, Ageing, AIRWAYS ICPs, SUBLINGUAL IMMUNOTHERAPY, PRECISION MEDICINE, IMMUNOLOGY/PRACTALL CONSENSUS REPORT, 3121 General medicine, internal medicine and other clinical medicine, Allergen immunotherapy, Rhinitis
Abstract

Allergic diseases often occur early in life and persist throughout life. This life-course perspective should be considered in allergen immunotherapy. In particular it is essential to understand whether this al treatment may be used in old age adults. The current paper was developed by a working group of AIRWAYS integrated care pathways for airways diseases, the model of chronic respiratory diseases of the European Innovation Partnership on active and healthy ageing (DG CONNECT and DG Sante). It considered (1) the political background, (2) the rationale for allergen immunotherapy across the life cycle, (3) the unmet needs for the treatment, in particular in preschool children and old age adults, (4) the strategic framework and the practical approach to synergize current initiatives in allergen immunotherapy, its mechanisms and the concept of active and healthy ageing.

Published
2016

25. Allergy immunotherapy across the life cycle to promote active and healthy ageing: From research to policies

Author

Calderon, M.A. Demoly, P. Casale, T. Akdis, C.A. Bachert, C. Bewick, M. Bilò, B.M. Bohle, B. Bonini, S. Bush, A. Caimmi, D.P. Canonica, G.W. Cardona, V. Chiriac, A.M. Cox, L. Custovic, A. De Blay, F. Devillier, P. Didier, A. Di Lorenzo, G. Du Toit, G. Durham, S.R. Eng, P. Fiocchi, A. Fox, A.T. Van Wijk, R.G. Gomez, R.M. Haathela, T. Halken, S. Hellings, P.W. Jacobsen, L. Just, J. Tanno, L.K. Kleine-Tebbe, J. Klimek, L. Knol, E.F. Kuna, P. Larenas-Linnemann, D.E. Linneberg, A. Matricardi, M. Malling, H.J. Moesges, R. Mullol, J. Muraro, A. Papadopoulos, N. Passalacqua, G. Pastorello, E. Pfaar, O. Price, D. Del Rio, P.R. Ruëff, R. Samolinski, B. Scadding, G.K. Senti, G. Shamji, M.H. Sheikh, A. Sisul, J.C. Sole, D. Sturm, G.J. Tabar, A. Van Ree, R. Ventura, M.T. Vidal, C. Varga, E.M. Worm, M. Zuberbier, T. Bousquet, J.

Abstract

Allergic diseases often occur early in life and persist throughout life. This life-course perspective should be considered in allergen immunotherapy. In particular it is essential to understand whether this al treatment may be used in old age adults. The current paper was developed by a working group of AIRWAYS integrated care pathways for airways diseases, the model of chronic respiratory diseases of the European Innovation Partnership on active and healthy ageing (DG CONNECT and DG Santé). It considered (1) the political background, (2) the rationale for allergen immunotherapy across the life cycle, (3) the unmet needs for the treatment, in particular in preschool children and old age adults, (4) the strategic framework and the practical approach to synergize current initiatives in allergen immunotherapy, its mechanisms and the concept of active and healthy ageing. © 2016 The Author(s).

Published
2016

26. Allergy immunotherapy across the life cycle to promote active and healthy ageing : from research to policies

Author

Calderon, MA, Demoly, P, Casale, T, Akdis, CA, Bachert, C, Bewick, M, Bilo, BM, Bohle, B, Bonini, S, Bush, A, Caimmi, DP, Canonica, GW, Cardona, V, Chiriac, AM, Cox, L, Custovic, A, De Blay, F, Devillier, P, Didier, A, Di Lorenzo, G, Du Toit, G, Durham, SR, Eng, P, Fiocchi, A, Fox, AT, Van Wijk, RG, Gomez, RM, Haathela, T, Halken, S, Hellings, PW, Jacobsen, L, Just, J, Tanno, LK, Kleine-Tebbe, J, Klimek, L, Knol, EF, Kuna, P, Larenas-Linnemann, DE, Linneberg, A, Matricardi, M, Malling, HJ, Moesges, R, Mullol, J, Muraro, A, Papadopoulos, N, Passalacqua, G, Pastorello, E, Pfaar, O, Price, D, Rodriguez del Rio, P, Rueff, R, Samolinski, B, Scadding, GK, Senti, G, Shamji, MH, Sheikh, A, Sisul, JC, Sole, D, Sturm, GJ, Tabar, A, Van Ree, R, Ventura, MT, Vidal, C, Varga, EM, Worm, M, Zuberbier, T, Bousquet, J, Internal Medicine, and Medical Research Council (MRC)

Subjects
Pulmonary and Respiratory Medicine, EIP on AHA, Science & Technology, EAACI POSITION PAPER, RUSH IMMUNOTHERAPY, Allergy, GRASS-POLLEN ALLERGY, INTERNATIONAL CONSENSUS, EUROPEAN INNOVATION PARTNERSHIP, Immunology, NATIONAL DATABASES, ORAL IMMUNOTHERAPY, Ageing, AIRWAYS ICPs, Allergen immunotherapy, Asthma, Rhinitis, Immunology and Allergy, SUBLINGUAL IMMUNOTHERAPY, PRECISION MEDICINE, IMMUNOLOGY/PRACTALL CONSENSUS REPORT, Medicine and Health Sciences, Life Sciences & Biomedicine
Abstract

European Innovation Partnership on Active and Healthy Ageing Reference Site MACVIA-France, European Structural and Development Funds of Region Languedoc Roussillon Allergic diseases often occur early in life and persist throughout life. This life-course perspective should be considered in allergen immunotherapy. In particular it is essential to understand whether this al treatment may be used in old age adults. The current paper was developed by a working group of AIRWAYS integrated care pathways for airways diseases, the model of chronic respiratory diseases of the European Innovation Partnership on active and healthy ageing (DG CONNECT and DG Sante). It considered (1) the political background, (2) the rationale for allergen immunotherapy across the life cycle, (3) the unmet needs for the treatment, in particular in preschool children and old age adults, (4) the strategic framework and the practical approach to synergize current initiatives in allergen immunotherapy, its mechanisms and the concept of active and healthy ageing. Imperial Coll London, Natl Heart & Lung Inst, Royal Brompton Hosp NHS, London, England UPMC Paris 06, Sorbonne Univ,Dept Pneumol & Addictol,UMR S 1136, Hop Arnaud de Villeneuve,CHRU Montpellier, IPLESP,Equipe EPAR,Unite Allergol, F-75013 Paris, France Univ S Florida, Morsani Coll Med, Tampa, FL USA Univ Zurich, Swiss Inst Allergy & Asthma Res SIAF, Christine Kuhne Ctr Allergy Res & Educ CK CARE, Davos, Switzerland Univ Hosp Ghent, ENT Dept, Upper Airways Res Lab URL, Ghent, Belgium IQ4U Consultants Ltd, London, England Osped Riuniti, Univ Hosp, Allergy Unit, Dept Internal Med, Ancona, Italy Med Univ Vienna, Dept Pathophysiol & Allergy Res, Ctr Pathophysiol Infectiol & Immunol, Vienna, Austria Univ Naples 2, Rome, Italy CNR, IFT, Rome, Italy Univ Genoa, Allergy & Resp Dis Clin, DIMI, IRCCS AOU San Martino IST, Genoa, Italy Hosp Univ Vall dHebron, Allergy Sect, Dept Internal Med, Barcelona, Spain Montpellier UPMC Univ Paris 06, Sorbonne Univ,UMRS 1136, Hop Arnaud de Villeneuve,Equipe EPAR IPLESP, Div Allergy,Dept Pulmonol,Univ Hosp Montpellier, Paris, France Nova Southeastern Univ, Ft Lauderdale, FL USA Univ Hosp Strasbourg, Div Allergy, Chest Dis Dept, Strasbourg, France Univ Versailles St Quentin, Suresnes, France Foch Hosp, Dept Airway Dis, Clin Pharmacol Unit, UPRES EA 220, Suresnes, France Rangueil Larrey Hosp, Dept Resp Dis, Toulouse, France Univ Palermo, Di Bi MIS, Palermo, Italy Kings Coll London, Guys & St Thomas NHS Trust, London, England Imperial Coll London, Natl Heart & Lung Inst, Allergy & Clin Immunol Sect, London, England Childrens Hosp, Dept Pediat Pulmonol & Allergy, Aarau, Switzerland Bambino Gesu Pediat Hosp, Dept Pediat, Div Allergy, Rome, Italy Kings Coll London, Allergy Acad, London, England Erasmus MC, Dept Internal Med, Bldg Rochussenstr, Rotterdam, Netherlands Hosp San Bernardo, Unidad Alergia & Asma, Salta, Argentina Helsinki Univ Hosp, Skin & Allergy Hosp, Helsinki, Finland Odense Univ Hosp, Hans Christian Andersen Childrens Hosp, Odense, Denmark Katholieke Univ Leuven, Univ Hosp Leuven, Clin Dept Otorhinolaryngol Head & Neck Surg, Louvain, Belgium Secretary Immunotherapy Interest Grp EAACI, Allergy Learning & Consulting, Copenhagen, Denmark UPMC Univ Paris, Sorbonne Univ,Hop Enfants Armand Trousseau,INSERM, Inst Pierre Louis Epidemiol & Sante Publ,Equipe E, Allergol Dept,Ctr Asthme & Allergies,UMR S 1136, Paris, France Hosp Sirio Libanes, Sao Paulo, Brazil Univ Hosp Montpellier, Montpellier, France UPMC Paris 06, Sorbonne Univ, Equipe EPAR, UMR S 1136,IPLESP, Paris, France Ackermann Hanf & Kleine Tebbe, Outpatient Clin & Clin Res Ctr, Allergy & Asthma Ctr Westend, Berlin, Germany German Soc Otorhinolaryngol HNS, Ctr Rhinol & Allergol, Wiesbaden, Germany Univ Med Ctr Utrecht, Dept Immunol & Dermatol Allergol, Utrecht, Netherlands Med Univ Lodz, Lodz, Poland ARIA, Mexico City, DF, Mexico Hosp Med Sur, AAAAI, Mexico City, DF, Mexico Capital Reg Denmark, Res Ctr Prevent & Hlth, Copenhagen, Denmark Rigshosp, Dept Clin Expt Res, Copenhagen, Denmark Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark Charite Med Univ, Pediat Pneumol & Immunol, Berlin, Germany Gentofte Univ Hosp, Allergy Clin, Danish Allergy Ctr, Hellerup, Denmark Klinikum Univ Koln AoR, IMSIE, Cologne, Germany Hosp Clin Barcelona, Unitat Rinol & Clin Olfacte, ENT Dept, Clin & Expt Resp Immunoallergy,IDIBAPS,CIBERES, Barcelona, Catalonia, Spain Padua Gen Univ Hosp, Dept Women & Child Hlth, Food Allergy Referral Ctr Veneto Reg, Padua, Italy Univ Athens, Allergy Unit, Pediat Clin 2, Athens, Greece Univ Genoa, Allergy & Resp Dis, IRCCS San Martino IST, Genoa, Italy ASST Grande Osped Metropolitano Niguarda, Pzza Osped Maggiore, Milan, Italy Univ Med Mannheim, Dept Otorhinolaryngol Head & Neck Surg, Mannheim, Germany Heidelberg Univ, Med Fac Mannheim, Heidelberg, Germany Ctr Rhinol & Allergol, Wiesbaden, Germany Univ Aberdeen, Acad Primary Care, Div Appl Hlth Sci, Primary Care Resp Med, Aberdeen, Scotland RiRL, Cambridge, England Optimum Patient Care Ltd, Singapore, Singapore Hosp Infantil Univ Nino Jesus, Allergy Sect, Madrid, Spain Ludwig Maximillian Univ, Dept Dermatol & Allergol, Munich, Germany Med Univ Warsaw, Dept Prevent Environm Hazards & Allergol, Warsaw, Poland Royal Natl Throat Nose & Ear Hosp, London, England UCL, London, England Univ Zurich Hosp, Clin Trials Ctr, Zurich, Switzerland Imperial Coll London, Natl Heart & Lung Inst, Allergy & Clin Immunol Inflammat Repair & Dev Sec, Immunomodulat & Tolerance Grp,Fac Med, London, England MRC, London, England Asthma UK Ctr Allerg Mechanisms Asthma, London, England Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Asthma UK Ctr Appl Res, Med Informat Ctr, Teviot Pl, Edinburgh EH8 9AG, Midlothian, Scotland SLAAI, Asuncion, Paraguay Univ Fed Sao Paulo, Programa Posgrad Pediat & Ciencias Aplicadas Pedi, Dept Pediat EPM, Sao Paulo, Brazil Med Univ Graz, Dept Dermatol & Venerol, Graz, Austria Allergy Outpatient Clin Reumannplatz, Vienna, Austria Complejo Hosp Navarra, Serv Alergol, Pamplona, Spain Univ Amsterdam, Acad Med Ctr, Dept Expt Immunol, Amsterdam, Netherlands Univ Amsterdam, Acad Med Ctr, Dept Otorhinolaryngol, Amsterdam, Netherlands Univ Bari, Sch Med, Unit Geriatr Immunoallergol, Interdisciplinary Dept Med, Bari, Italy Complejo Hosp Univ Santiago de Compostela, Dept Allergy, Santiago De Compostela, Spain Med Univ Graz, Dept Paediat, Resp & Allerg Dis Div, Graz, Austria Charite Univ Med Berlin, Klin Dermatol Venerol & Allergol, Allergie Ctr Charite, Berlin, Germany European Innovat Partnership Act & Hlth Ageing Re, MAlad Chron Vleillissement Actif Languedoc Roussi, Paris, France INSERM, VIMA, Epidemiol & Publ Hlth Approaches, U1168,Ageing & Chron Dis, Paris, France Univ Versailles St Quentin En Yvelines, UVSQ, UMR S 1168, Versailles, France CHRU, 371 Ave Doyen Gaston Giraud, F-34295 Montpellier 5, France Programa de Pòs‑Graduação em Pediatria e Ciências Aplicadas à Pediatria, Departamento de Pediatria EPM, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil Web of Science

Published
2016
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31. Allergy immunotherapy across the life cycle to promote active and healthy ageing : from research to policies: An AIRWAYS Integrated Care Pathways (ICPs) programme item (Action Plan B3 of the European Innovation Partnership on active and healthy ageing) and the Global Alliance against Chronic Respiratory Diseases (GARD), a World Health Organization GARD research demonstration project

Author

Calderon, M A, Demoly, P, Casale, T, Akdis, C A, Bachert, C, Bewick, M, Bilò, B M, Bohle, B, Bonini, S, Bush, A, Caimmi, D P, Canonica, G W, Cardona, V, Chiriac, A M, Cox, L, Custovic, A, De Blay, F, Devillier, P, Didier, A, Di Lorenzo, G, Du Toit, G, Durham, S R, Eng, P, Fiocchi, A, Fox, A T, van Wijk, R Gerth, Gomez, R M, Haathela, T, Halken, S, Hellings, P W, Jacobsen, L, Just, J, Tanno, L K, Kleine-Tebbe, J, Klimek, L, Knol, EF, Kuna, P, Larenas-Linnemann, D E, Linneberg, A, Matricardi, M, Malling, H J, Moesges, R, Mullol, J, Muraro, A, Papadopoulos, N, Passalacqua, G, Pastorello, E, Pfaar, O, Price, D, Del Rio, P Rodriguez, Ruëff, R, Samolinski, B, Scadding, G K, Senti, G, Shamji, M H, Sheikh, A, Sisul, J C, Sole, D, Sturm, G J, Tabar, A, Van Ree, R, Ventura, M T, Vidal, C, Varga, E M, Worm, M, Zuberbier, T, Bousquet, J, Calderon, M A, Demoly, P, Casale, T, Akdis, C A, Bachert, C, Bewick, M, Bilò, B M, Bohle, B, Bonini, S, Bush, A, Caimmi, D P, Canonica, G W, Cardona, V, Chiriac, A M, Cox, L, Custovic, A, De Blay, F, Devillier, P, Didier, A, Di Lorenzo, G, Du Toit, G, Durham, S R, Eng, P, Fiocchi, A, Fox, A T, van Wijk, R Gerth, Gomez, R M, Haathela, T, Halken, S, Hellings, P W, Jacobsen, L, Just, J, Tanno, L K, Kleine-Tebbe, J, Klimek, L, Knol, EF, Kuna, P, Larenas-Linnemann, D E, Linneberg, A, Matricardi, M, Malling, H J, Moesges, R, Mullol, J, Muraro, A, Papadopoulos, N, Passalacqua, G, Pastorello, E, Pfaar, O, Price, D, Del Rio, P Rodriguez, Ruëff, R, Samolinski, B, Scadding, G K, Senti, G, Shamji, M H, Sheikh, A, Sisul, J C, Sole, D, Sturm, G J, Tabar, A, Van Ree, R, Ventura, M T, Vidal, C, Varga, E M, Worm, M, Zuberbier, T, and Bousquet, J

Published
2016

32. Allergy immunotherapy across the life cycle to promote active and healthy ageing

Author

University of Helsinki, Clinicum, Calderon, M. A., Demoly, P., Casale, T., Akdis, C. A., Bachert, C., Bewick, M., Bilo, B. M., Bohle, B., Bonini, S., Bush, A., Caimmi, D. P., Canonica, G. W., Cardona, V., Chiriac, A. M., Cox, L., Custovic, A., De Blay, F., Devillier, P., Didier, A., Di Lorenzo, G., Du Toit, G., Durham, S. R., Eng, P., Fiocchi, A., Fox, A. T., van Wijk, R. Gerth, Gomez, R. M., Haahtela, Tari Markku Kallevi, Halken, S., Hellings, P. W., Jacobsen, L., Just, J., Tanno, L. K., Kleine-Tebbe, J., Klimek, L., Knol, E. F., Kuna, P., Larenas-Linnemann, D. E., Linneberg, A., Matricardi, M., Malling, H. J., Moesges, R., Mullol, J., Muraro, A., Papadopoulos, N., Passalacqua, G., Pastorello, E., Pfaar, O., Price, D., Rodriguez del Rio, P., Rueff, R., Samolinski, B., Scadding, G. K., Senti, G., Shamji, M. H., Sheikh, A., Sisul, J. C., Sole, D., Sturm, G. J., Tabar, A., Van Ree, R., Ventura, M. T., Vidal, C., Varga, E. M., Worm, M., Zuberbier, T., Bousquet, J., University of Helsinki, Clinicum, Calderon, M. A., Demoly, P., Casale, T., Akdis, C. A., Bachert, C., Bewick, M., Bilo, B. M., Bohle, B., Bonini, S., Bush, A., Caimmi, D. P., Canonica, G. W., Cardona, V., Chiriac, A. M., Cox, L., Custovic, A., De Blay, F., Devillier, P., Didier, A., Di Lorenzo, G., Du Toit, G., Durham, S. R., Eng, P., Fiocchi, A., Fox, A. T., van Wijk, R. Gerth, Gomez, R. M., Haahtela, Tari Markku Kallevi, Halken, S., Hellings, P. W., Jacobsen, L., Just, J., Tanno, L. K., Kleine-Tebbe, J., Klimek, L., Knol, E. F., Kuna, P., Larenas-Linnemann, D. E., Linneberg, A., Matricardi, M., Malling, H. J., Moesges, R., Mullol, J., Muraro, A., Papadopoulos, N., Passalacqua, G., Pastorello, E., Pfaar, O., Price, D., Rodriguez del Rio, P., Rueff, R., Samolinski, B., Scadding, G. K., Senti, G., Shamji, M. H., Sheikh, A., Sisul, J. C., Sole, D., Sturm, G. J., Tabar, A., Van Ree, R., Ventura, M. T., Vidal, C., Varga, E. M., Worm, M., Zuberbier, T., and Bousquet, J.

Abstract

Allergic diseases often occur early in life and persist throughout life. This life-course perspective should be considered in allergen immunotherapy. In particular it is essential to understand whether this al treatment may be used in old age adults. The current paper was developed by a working group of AIRWAYS integrated care pathways for airways diseases, the model of chronic respiratory diseases of the European Innovation Partnership on active and healthy ageing (DG CONNECT and DG Sante). It considered (1) the political background, (2) the rationale for allergen immunotherapy across the life cycle, (3) the unmet needs for the treatment, in particular in preschool children and old age adults, (4) the strategic framework and the practical approach to synergize current initiatives in allergen immunotherapy, its mechanisms and the concept of active and healthy ageing.

Published
2016

33. Allergy immunotherapy across the life cycle to promote active and healthy ageing: From research to policies

Author

Calderon, M. (Moises), Demoly, P., Casale, T.B. (Thomas), Akdis, C.A., Bachert, C. (Claus), Bewick, M., Bilò, B.M., Bohle, B. (B.), Bonini, S. (Sergio), Bush, A. (Andrew), Caimmi, D.P., Canonica, G. (Gwalter), Cardona, D. (Doris), Chiriac, A.M. (A.), Cox, L. (Linda), Custovic, A. (Adnan), Blay, F. de, Devillier, P., Didier, A., Di Lorenzo, G., Du Toit, G. (George), Durham, S.R. (Stephen), Eng, C. (Charis), Fiocchi, A. (Alessandro), Fox, A.T., Gerth van Wijk, R. (Roy), Gomez, R.M., Haathela, T., Halken, S. (Susanne), Hellings, P.W. (Peter), Jacobsen, L., Just, P.M., Tanno, L.K., Kleine-Tebbe, J. (Jörg), Klimek, L. (Ludger), Knol, E.F. (Edward Frank), Kuna, P. (Piotr), Larenas-Linnemann, D. (Désirée), Linneberg, A. (Allan), Matricardi, M., Malling, H.-J., Moesges, R., Mullol, J., Muraro, A., Papadopoulos, N., Passalacqua, G. (Giovanni), Pastorello, E., Pfaar, O. (Oliver), Price, D. (David), Del Rio, P.R. (P. Rodriguez), Ruëff, R., Samolinski, B., Scadding, G.K., Senti, G., Shamji, M.H., Sheikh, A. (Aziz), Sisul, J.C. (J.), Solé, D. (D.), Sturm, G.J., Tabar, A., Van Ree, R., Ventura, M.T., Vidal, C. (Carmen), Varga, E.M., Worm, M. (M.), Zuberbier, T. (Torsten), Bousquet, J. (Jean), Calderon, M. (Moises), Demoly, P., Casale, T.B. (Thomas), Akdis, C.A., Bachert, C. (Claus), Bewick, M., Bilò, B.M., Bohle, B. (B.), Bonini, S. (Sergio), Bush, A. (Andrew), Caimmi, D.P., Canonica, G. (Gwalter), Cardona, D. (Doris), Chiriac, A.M. (A.), Cox, L. (Linda), Custovic, A. (Adnan), Blay, F. de, Devillier, P., Didier, A., Di Lorenzo, G., Du Toit, G. (George), Durham, S.R. (Stephen), Eng, C. (Charis), Fiocchi, A. (Alessandro), Fox, A.T., Gerth van Wijk, R. (Roy), Gomez, R.M., Haathela, T., Halken, S. (Susanne), Hellings, P.W. (Peter), Jacobsen, L., Just, P.M., Tanno, L.K., Kleine-Tebbe, J. (Jörg), Klimek, L. (Ludger), Knol, E.F. (Edward Frank), Kuna, P. (Piotr), Larenas-Linnemann, D. (Désirée), Linneberg, A. (Allan), Matricardi, M., Malling, H.-J., Moesges, R., Mullol, J., Muraro, A., Papadopoulos, N., Passalacqua, G. (Giovanni), Pastorello, E., Pfaar, O. (Oliver), Price, D. (David), Del Rio, P.R. (P. Rodriguez), Ruëff, R., Samolinski, B., Scadding, G.K., Senti, G., Shamji, M.H., Sheikh, A. (Aziz), Sisul, J.C. (J.), Solé, D. (D.), Sturm, G.J., Tabar, A., Van Ree, R., Ventura, M.T., Vidal, C. (Carmen), Varga, E.M., Worm, M. (M.), Zuberbier, T. (Torsten), and Bousquet, J. (Jean)

Abstract

Allergic diseases often occur early in life and persist throughout life. This life-course perspective should be considered in allergen immunotherapy. In particular it is essential to understand whether this al treatment may be used in old age adults. The current paper was developed by a working group of AIRWAYS integrated care pathways for airways diseases, the model of chronic respiratory diseases of the European Innovation Partnership on active and healthy ageing (DG CONNECT and DG Santé). It considered (1) the political background, (2) the rationale for allergen immunotherapy across the life cycle, (3) the unmet needs for the treatment, in particular in preschool children and old age adults, (4) the strategic framework and the practical approach to synergize current initiatives in allergen immunotherapy, its mechanisms and the concept of active and healthy ageing.

Published
2016
Full Text
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34. Allergy immunotherapy across the life cycle to promote active and healthy ageing: from research to policies: An AIRWAYS Integrated Care Pathways (ICPs) programme item (Action Plan B3 of the European Innovation Partnership on active and healthy ageing) and the Global Alliance against Chronic Respiratory Diseases (GARD), a World Health Organization GARD research demonstration project

Author

MS Dermatologie/Allergologie, CDL Celdiagnostiek, Infection & Immunity, Calderon, M A, Demoly, P, Casale, T, Akdis, C A, Bachert, C, Bewick, M, Bilò, B M, Bohle, B, Bonini, S, Bush, A, Caimmi, D P, Canonica, G W, Cardona, V, Chiriac, A M, Cox, L, Custovic, A, De Blay, F, Devillier, P, Didier, A, Di Lorenzo, G, Du Toit, G, Durham, S R, Eng, P, Fiocchi, A, Fox, A T, van Wijk, R Gerth, Gomez, R M, Haathela, T, Halken, S, Hellings, P W, Jacobsen, L, Just, J, Tanno, L K, Kleine-Tebbe, J, Klimek, L, Knol, EF, Kuna, P, Larenas-Linnemann, D E, Linneberg, A, Matricardi, M, Malling, H J, Moesges, R, Mullol, J, Muraro, A, Papadopoulos, N, Passalacqua, G, Pastorello, E, Pfaar, O, Price, D, Del Rio, P Rodriguez, Ruëff, R, Samolinski, B, Scadding, G K, Senti, G, Shamji, M H, Sheikh, A, Sisul, J C, Sole, D, Sturm, G J, Tabar, A, Van Ree, R, Ventura, M T, Vidal, C, Varga, E M, Worm, M, Zuberbier, T, Bousquet, J, MS Dermatologie/Allergologie, CDL Celdiagnostiek, Infection & Immunity, Calderon, M A, Demoly, P, Casale, T, Akdis, C A, Bachert, C, Bewick, M, Bilò, B M, Bohle, B, Bonini, S, Bush, A, Caimmi, D P, Canonica, G W, Cardona, V, Chiriac, A M, Cox, L, Custovic, A, De Blay, F, Devillier, P, Didier, A, Di Lorenzo, G, Du Toit, G, Durham, S R, Eng, P, Fiocchi, A, Fox, A T, van Wijk, R Gerth, Gomez, R M, Haathela, T, Halken, S, Hellings, P W, Jacobsen, L, Just, J, Tanno, L K, Kleine-Tebbe, J, Klimek, L, Knol, EF, Kuna, P, Larenas-Linnemann, D E, Linneberg, A, Matricardi, M, Malling, H J, Moesges, R, Mullol, J, Muraro, A, Papadopoulos, N, Passalacqua, G, Pastorello, E, Pfaar, O, Price, D, Del Rio, P Rodriguez, Ruëff, R, Samolinski, B, Scadding, G K, Senti, G, Shamji, M H, Sheikh, A, Sisul, J C, Sole, D, Sturm, G J, Tabar, A, Van Ree, R, Ventura, M T, Vidal, C, Varga, E M, Worm, M, Zuberbier, T, and Bousquet, J

Published
2016

35. Allergy immunotherapy across the life cycle to promote active and healthy ageing:from research to policies: An AIRWAYS Integrated Care Pathways (ICPs) programme item (Action Plan B3 of the European Innovation Partnership on active and healthy ageing) and the Global Alliance against Chronic Respiratory Diseases (GARD), a World Health Organization GARD research demonstration project

Author

Calderon, M A, Demoly, P, Casale, T, Akdis, C A, Bachert, C, Bewick, M, Bilò, B M, Bohle, B, Bonini, S, Bush, A, Caimmi, D P, Canonica, G W, Cardona, V, Chiriac, A M, Cox, L, Custovic, A, De Blay, F, Devillier, P, Didier, A, Di Lorenzo, G, Du Toit, G, Durham, S R, Eng, P, Fiocchi, A, Fox, A T, van Wijk, R Gerth, Gomez, R M, Haathela, T, Halken, S, Hellings, P W, Jacobsen, L, Just, J, Tanno, L K, Kleine-Tebbe, J, Klimek, L, Knol, E F, Kuna, P, Larenas-Linnemann, D E, Linneberg, A, Matricardi, M, Malling, H J, Moesges, R, Mullol, J, Muraro, A, Papadopoulos, N, Passalacqua, G, Pastorello, E, Pfaar, O, Price, D, Del Rio, P Rodriguez, Ruëff, R, Samolinski, B, Scadding, G K, Senti, G, Shamji, M H, Sheikh, A, Sisul, J C, Sole, D, Sturm, G J, Tabar, A, Van Ree, R, Ventura, M T, Vidal, C, Varga, E M, Worm, M, Zuberbier, T, Bousquet, J, Calderon, M A, Demoly, P, Casale, T, Akdis, C A, Bachert, C, Bewick, M, Bilò, B M, Bohle, B, Bonini, S, Bush, A, Caimmi, D P, Canonica, G W, Cardona, V, Chiriac, A M, Cox, L, Custovic, A, De Blay, F, Devillier, P, Didier, A, Di Lorenzo, G, Du Toit, G, Durham, S R, Eng, P, Fiocchi, A, Fox, A T, van Wijk, R Gerth, Gomez, R M, Haathela, T, Halken, S, Hellings, P W, Jacobsen, L, Just, J, Tanno, L K, Kleine-Tebbe, J, Klimek, L, Knol, E F, Kuna, P, Larenas-Linnemann, D E, Linneberg, A, Matricardi, M, Malling, H J, Moesges, R, Mullol, J, Muraro, A, Papadopoulos, N, Passalacqua, G, Pastorello, E, Pfaar, O, Price, D, Del Rio, P Rodriguez, Ruëff, R, Samolinski, B, Scadding, G K, Senti, G, Shamji, M H, Sheikh, A, Sisul, J C, Sole, D, Sturm, G J, Tabar, A, Van Ree, R, Ventura, M T, Vidal, C, Varga, E M, Worm, M, Zuberbier, T, and Bousquet, J

Abstract

Allergic diseases often occur early in life and persist throughout life. This life-course perspective should be considered in allergen immunotherapy. In particular it is essential to understand whether this al treatment may be used in old age adults. The current paper was developed by a working group of AIRWAYS integrated care pathways for airways diseases, the model of chronic respiratory diseases of the European Innovation Partnership on active and healthy ageing (DG CONNECT and DG Santé). It considered (1) the political background, (2) the rationale for allergen immunotherapy across the life cycle, (3) the unmet needs for the treatment, in particular in preschool children and old age adults, (4) the strategic framework and the practical approach to synergize current initiatives in allergen immunotherapy, its mechanisms and the concept of active and healthy ageing.

Published
2016

36. EAACI: a European declaration on immunotherapy. Design the future of allergen specific immunotherapy

Author

Calderon, MA, Demoly, P, Gerth van Wijk, Roy, Bousquet, J, Sheikh, A (Aziz), Frew, A, Scadding, GK, Bachert, C, Malling, H-J, Valenta, R, Bilo, B, Nieto, A, Akdis, CA, Just, J, Vidal, C, Varga, EM, Alvarez-Cuesta, E, Bohle, E, Bufe, A, Canonica, GW, Cardona, V, Dahl, R, Didier, A, Durham, SR, Eng, P, Fernandez-Rivas, M, Jacobsen, L, Jutel, M, Klein-Tebbe, J, Klimek, L, Lotvall, J, Moreno, C, Mosges, R, Muraro, A, Niggemann, B, Pajno, G, Passalacqua, G, Pfaar, O, Rak, S, Senna, GE, Senti, G, Valovirta, E, van Hage, M, Virchow, JC, Wahn, U, Papadopoulos, N, and Internal Medicine

Published
2012

37. Intralymphatic vaccination

Author

Kündig, T M, Johansen, P, Senti, G, University of Zurich, Rappuoli, R, and Bagnoli, F

Subjects
10177 Dermatology Clinic, 610 Medicine & health
Published
2011

48. Double-blind, placebo-controlled study with sublingual immunotherapy in children with seasonal allergic rhinitis to grass pollen

Author

Wüthrich, B, Bucher, Ch, Jörg, W, Bircher, A, Eng, P, Schneider, Y, Schnyder, F, Eigenmann, Philippe, and Senti, G

Subjects
Male, Conjunctivitis, Allergic/diagnosis/drug therapy, Administration, Sublingual, Pollen/immunology, Poaceae, Severity of Illness Index, Statistics, Nonparametric, Double-Blind Method, Reference Values, Desensitization, Immunologic/methods, otorhinolaryngologic diseases, Humans, Child, Conjunctivitis, Allergic, ddc:618, Poaceae/immunology, Plant Extracts, food and beverages, Rhinitis, Allergic, Seasonal, Allergens, Patch Tests, eye diseases, Allergens/adverse effects, Treatment Outcome, Desensitization, Immunologic, Child, Preschool, Immunotherapy/methods, Pollen, Female, sense organs, Immunotherapy, Plant Extracts/therapeutic use, Rhinitis, Allergic, Seasonal/diagnosis/drug therapy, Follow-Up Studies
Abstract

Sublingual immunotherapy (SLIT) has been recognized as a viable alternative to subcutaneous immunotherapy for respiratory allergies both in adults and children, but clinical documentation about safety and efficacy in children is still poor. The purpose of this study was to assess the efficacy and tolerance of SLIT in children who are sensitized to grass pollen.Children with a clinical history of intermittent rhinoconjunctivitis, with or without mild asthma and positive skin prick tests to grass pollen, were selected to participate in a 2-year double-blind, placebo-controlled study with SLIT, using a grass extract (ALK-Abellò).22 children were analyzed at the end of the study. No relevant side effects occurred in the active group. A statistically significant difference (p = 0.05; Mann-Whitney test) in favor of the active group (n = 10) could be shown for drug consumption during the second year, as well as a significant improvement as compared to the first year of SLIT (p = 0.05; Wilcoxon test).Despite the small number of patients, our data suggest that SLIT with a grass pollen extract is well tolerated in children and is able to significantly reduce drug consumption during the second year of treatment. Studies in larger groups of children sensitized to both grass and tree pollens are needed to definitively assess the role of SLIT in intermittent, seasonal rhinitis and pollen asthma.

Published
2003

49. EAACI: A European Declaration on Immunotherapy. Designing the future of allergen specific immunotherapy

Author

Calderon, M. (Moises), Demoly, P., Gerth van Wijk, R. (Roy), Bousquet, J. (Jean), Sheikh, A. (Aziz), Frew, A.J. (Antony J.), Scadding, G.K., Bachert, C. (Claus), Malling, H.-J., Valenta, R. (Rudolph), Bilo, B. (Beatrice), Nieto, A. (Antonio), Akdis, C.A., Just, P.M., Vidal, C. (Carmen), Varga, E.M., Alvarez-Cuesta, E. (Emilio), Bohle, B. (B.), Bufe, A. (A.), Canonica, W. (Walter), Cardona, D. (Doris), Dahl, R., Didier, A. (Alain), Durham, S.R. (Stephen), Eng, C. (Charis), Fernandez Rivas, M. (M.), Jacobsen, L., Jutel, M. (M.), Kleine-Tebbe, J. (Jörg), Klimek, L. (Ludger), Lötvall, J. (Jan), Moreno, C. (Carmen), Mösges, R. (Ralph), Muraro, A. (Antonella), Niggemann, B., Pajno, G. (G.), Passalacqua, G. (Giovanni), Pfaar, O. (Oliver), Rak, S., Senna, G.E. (Gianenrico), Senti, G. (Gabriela), Valovirta, E. (Erkka), Hage, M. (Marianne) van, Virchow, J.C. (Johannes C), Wahn, U. (Ulrich), Papadopoulos, N., Calderon, M. (Moises), Demoly, P., Gerth van Wijk, R. (Roy), Bousquet, J. (Jean), Sheikh, A. (Aziz), Frew, A.J. (Antony J.), Scadding, G.K., Bachert, C. (Claus), Malling, H.-J., Valenta, R. (Rudolph), Bilo, B. (Beatrice), Nieto, A. (Antonio), Akdis, C.A., Just, P.M., Vidal, C. (Carmen), Varga, E.M., Alvarez-Cuesta, E. (Emilio), Bohle, B. (B.), Bufe, A. (A.), Canonica, W. (Walter), Cardona, D. (Doris), Dahl, R., Didier, A. (Alain), Durham, S.R. (Stephen), Eng, C. (Charis), Fernandez Rivas, M. (M.), Jacobsen, L., Jutel, M. (M.), Kleine-Tebbe, J. (Jörg), Klimek, L. (Ludger), Lötvall, J. (Jan), Moreno, C. (Carmen), Mösges, R. (Ralph), Muraro, A. (Antonella), Niggemann, B., Pajno, G. (G.), Passalacqua, G. (Giovanni), Pfaar, O. (Oliver), Rak, S., Senna, G.E. (Gianenrico), Senti, G. (Gabriela), Valovirta, E. (Erkka), Hage, M. (Marianne) van, Virchow, J.C. (Johannes C), Wahn, U. (Ulrich), and Papadopoulos, N.

Abstract

Allergy today is a public health concern of pandemic proportions, affecting more than 150 million people in Europe alone. In view of epidemiological trends, the European Academy of Allergy and Clinical Immunology (EAACI) predicts that within the next few decades, more than half of the European population may at some point in their lives experience some type of allergy. Not only do allergic patients suffer from a debilitating disease, with the potential for major impact on their quality of life, career progression, personal development and lifestyle choices, but they also constitute a significant burden on health economics and macroeconomics due to the days of lost productivity and underperformance. Given that allergy triggers, including urbanization, industrialization, pollution and climate change, are not expected to change in the foreseeable future, it is imperative that steps are taken to develop, strengthen and optimize preventive and treatment strategies. Allergen specific immunotherapy is the only currently available medical intervention that has the potential to affect the natural course of the disease. Years of basic science research, clinical trials, and systematic reviews and meta-analyses have convincingly shown that allergen specific immunotherapy can achieve substantial results for patients, improving the allergic individuals' quality of life, reducing the long-term costs and burden of allergies, and changing the course of the disease. Allergen specific immunotherapy not only effectively alleviates allergy symptoms, but it has a long-term effect after conclusion of the treatment and can prevent the progression of allergic diseases. Unfortunately, allergen specific immunotherapy has not yet received adequate attention from European institutions, including research funding bodies, even though this could be a most rewarding field in terms of return on investments, translational value and European integration and, a field

Published
2012
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50. Intralymphatic immunotherapy: from the rationale to human applications

Author

Valenta, R, Coffman, R L, Valenta, R ( R ), Coffman, R L ( R L ), Senti, G, Johansen, P; https://orcid.org/0000-0002-5055-6299, Kündig, T M, Valenta, R, Coffman, R L, Valenta, R ( R ), Coffman, R L ( R L ), Senti, G, Johansen, P; https://orcid.org/0000-0002-5055-6299, and Kündig, T M

Abstract

Allergen specific immunotherapy (SIT) is the only treatment of IgE mediated allergies that is causative and has a long-term effect. Classically, SIT requires numerous subcutaneous injections of the allergen during 3-5 years. Over the last decade sublingual allergen applications have established as an alternative, but treatment duration could not be shortened. This review focuses on direct administration of vaccines in general and of allergens in particular into lymph nodes with the aim to enhance immunotherapy. Several studies have found that direct injection of antigens into lymph nodes enhanced immune responses. Recently we have focused on intralymphatic allergen administration in order to enhance SIT. Data in mouse models and in clinical trials showed that intralymphatic allergen administration strongly enhanced SIT, so that the number of allergen injections could be reduced to three, and the allergen dose could be reduced 10-100 fold. Intralymphatic injections proved easy, practically painless and safe. In mice and men, intralymphatic immunotherapy injecting allergens into a subcutaneous lymph node markedly enhances the protective immune response, so that both the dose and number of allergen injections can be reduced, making SIT safer and faster, which enhances patient convenience and compliance.

Published
2011

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