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Your search keyword '"Seneviratne, Anusha N."' showing total 7 results
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7 results on '"Seneviratne, Anusha N."'

3. CD200 Limits Monopoiesis and Monocyte Recruitment in Atherosclerosis

Author

Kassiteridi, Christina, primary, Cole, Jennifer E., additional, Griseri, Thibault, additional, Falck-Hansen, Mika, additional, Goddard, Michael E., additional, Seneviratne, Anusha N., additional, Green, Patricia A., additional, Park, Inhye, additional, Shami, Annelie G., additional, Pattarabanjird, Tanyaporn, additional, Upadhye, Aditi, additional, Taylor, Angela M., additional, Handa, Ashok, additional, Channon, Keith M., additional, Lutgens, Esther, additional, McNamara, Coleen A., additional, Williams, Richard O., additional, and Monaco, Claudia, additional

Published
2021
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7. Role of inflammatory cells and toll-like receptors in atherosclerosis.

Author

Seneviratne AN and Monaco C

Subjects
Animals, Anti-Inflammatory Agents therapeutic use, Atherosclerosis drug therapy, Atherosclerosis epidemiology, Atherosclerosis immunology, Cerebrovascular Disorders drug therapy, Cerebrovascular Disorders epidemiology, Cerebrovascular Disorders immunology, Cytokines immunology, Humans, Inflammation drug therapy, Inflammation epidemiology, Inflammation immunology, Inflammation Mediators metabolism, Ligands, Macrophages drug effects, Macrophages immunology, Molecular Targeted Therapy, Risk Factors, Signal Transduction, Toll-Like Receptors antagonists & inhibitors, Toll-Like Receptors immunology, Atherosclerosis metabolism, Cerebrovascular Disorders metabolism, Immunity, Innate drug effects, Inflammation metabolism, Macrophages metabolism, Toll-Like Receptors metabolism
Abstract

The primary cause of cerebrovascular disease is atherosclerosis, to which many factors contribute. At first many saw atherosclerosis as a lipid-driven disease. Recently inflammation has appeared as a significant factor in the disease. Innate immune cells, for example monocytes and macrophages, are important in atherosclerosis. Toll-like receptors (TLRs) are the best-studied family of receptor in the immune system. TLR engagement with their ligands stimulates pro-inflammatory cytokine production and foam cell generation. Recently certain TLRs have shown a protective role in atherosclerosis. In this review, we analyse innate immunity, focusing on TLR signalling and macrophages, in atherosclerosis and acute cerebrovascular complications, and thereby discuss their potential as therapeutic targets.

Published
2015
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