1,356 results on '"Senes A"'
Search Results
2. Pomalidomide in patients with multiple myeloma: potential impact on the reconstitution of a functional T-cell immunity
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Shen, Jiaxin, Senes, Francesca, Wen, Xiaofen, Monti, Patrizia, Lin, Shaoze, Pinna, Claudia, Murtas, Andrea, Podda, Luigi, Muntone, Giuseppina, Tidore, Gianni, Arru, Claudia, Sanna, Luca, Contini, Salvatore, Virdis, Patrizia, Sechi, Leonardo Antonio, and Fozza, Claudio
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- 2024
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3. Evaluation of the implementation of the rational use of laboratory tests in the clinical chemistry laboratory
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Serin Huriye, Orhan Bagnu, Say Merve S., Arslan Hilmi F., Inal Sinemis, Inal Berrin B., and Senes Mehmet
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autoverification ,consultation ,harmonization ,rational laboratory ,reflex or reflective testing ,Biochemistry ,QD415-436 - Abstract
The ‘Rational Laboratory Use Project’ (RLUP) was launched in 2018 by the Department of Examination and Diagnosis Services under the General Directorate of Health Services of the Republic of Turkey’s Ministry of Health. In this study, we aimed to determine the rate of implementation of RLUP in medical biochemistry laboratories, and to contribute to new regulations by collecting the information and opinions of the laboratory experts participating the survey.
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- 2024
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4. The AWAKE Run 2 programme and beyond
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Gschwendtner, Edda, Lotov, Konstantin, Muggli, Patric, Wing, Matthew, Agnello, Riccardo, Ahdida, Claudia Christina, Goncalves, Maria Carolina Amoedo, Andrebe, Yanis, Apsimon, Oznur, Apsimon, Robert, Arnesano, Jordan Matias, Bachmann, Anna-Maria, Barrientos, Diego, Batsch, Fabian, Bencini, Vittorio, Bergamaschi, Michele, Blanchard, Patrick, Burrows, Philip Nicholas, Buttenschön, Birger, Caldwell, Allen, Chappell, James, Chevallay, Eric, Chung, Moses, Cooke, David Andrew, Damerau, Heiko, Davut, Can, Demeter, Gabor, Dexter, Amos Christopher, Doebert, Steffen, Elverson, Francesa Ann, Farmer, John, Fasoli, Ambrogio, Fedosseev, Valentin, Fonseca, Ricardo, Furno, Ivo, Gessner, Spencer, Gorn, Aleksandr, Granados, Eduardo, Granetzny, Marcel, Graubner, Tim, Grulke, Olaf, Guran, Eloise Daria, Hafych, Vasyl, Hartin, Anthony, Henderson, James, Hüther, Mathias, Kedves, Miklos, Keeble, Fearghus, Khudiakov, Vadim, Kim, Seong-Yeol, Kraus, Florian, Krupa, Michel, Lefevre, Thibaut, Liang, Linbo, Liu, Shengli, Lopes, Nelson, Calderon, Miguel Martinez, Mazzoni, Stefano, Godoy, David Medina, Moody, Joshua, Moon, Kookjin, Guzmán, Pablo Israel Morales, Moreira, Mariana, Nechaeva, Tatiana, Nowak, Elzbieta, Pakuza, Collette, Panuganti, Harsha, Pardons, Ans, Pepitone, Kevin, Perera, Aravinda, Pucek, Jan, Pukhov, Alexander, Ramjiawan, Rebecca Louise, Rey, Stephane, Scaachi, Adam, Schmitz, Oliver, Senes, Eugenio, Silva, Fernando, Silva, Luis, Stollberg, Christine, Sublet, Alban, Swain, Catherine, Topaloudis, Athanasios, Torrado, Nuno, Tuev, Petr, Turner, Marlene, Velotti, Francesco, Verra, Livio, Verzilov, Victor, Vieira, Jorge, Vincke, Helmut, Weidl, Martin, Welsch, Carsten, Wendt, Manfred, Wiwattananon, Peerawan, Wolfenden, Joseph, Woolley, Benjamin, Wyler, Samuel, Xia, Guoxing, Yarygova, Vlada, Zepp, Michael, and Della Porta, Giovanni Zevi
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Physics - Accelerator Physics ,High Energy Physics - Experiment ,Physics - Plasma Physics - Abstract
Plasma wakefield acceleration is a promising technology to reduce the size of particle accelerators. Use of high energy protons to drive wakefields in plasma has been demonstrated during Run 1 of the AWAKE programme at CERN. Protons of energy 400 GeV drove wakefields that accelerated electrons to 2 GeV in under 10 m of plasma. The AWAKE collaboration is now embarking on Run 2 with the main aims to demonstrate stable accelerating gradients of 0.5-1 GV/m, preserve emittance of the electron bunches during acceleration and develop plasma sources scalable to 100s of metres and beyond. By the end of Run 2, the AWAKE scheme should be able to provide electron beams for particle physics experiments and several possible experiments have already been evaluated. This article summarises the programme of AWAKE Run 2 and how it will be achieved as well as the possible application of the AWAKE scheme to novel particle physics experiments., Comment: 21 pages, 8 figures. Submitted to Symmetry journal
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- 2022
5. Morphological and Metabolic Features of Brain Aging in Rodents, Ruminants, Carnivores, and Non-Human Primates
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Gianluca Lepore, Sara Succu, Maria Grazia Cappai, Adele Frau, Alice Senes, Marco Zedda, Vittorio Farina, and Sergio D. Gadau
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brain aging ,caloric restriction ,mammals ,metabolism ,neural cells ,nutrients ,Veterinary medicine ,SF600-1100 ,Zoology ,QL1-991 - Abstract
Brain aging in mammals is characterized by morphological and functional changes in neural cells. Macroscopically, this process, leading to progressive cerebral volume loss and functional decline, includes memory and motor neuron deficits, as well as behavioral disorders. Morphologically, brain aging is associated with aged neurons and astrocytes, appearing enlarged and flattened, and expressing enhanced pH-dependent β-galactosidase activity. Multiple mechanisms are considered hallmarks of cellular senescence in vitro, including cell cycle arrest, increased lysosomal activity, telomere shortening, oxidative stress, and DNA damage. The most common markers for senescence identification were identified in (i) proteins implicated in cell cycle arrest, such as p16, p21, and p53, (ii) increased lysosomal mass, and (iii) increased reactive oxygen species (ROS) and senescence-associated secretory phenotype (SASP) expression. Finally, dysfunctional autophagy, a process occurring during aging, contributes to altering brain homeostasis. The brains of mammals can be studied at cellular and subcellular levels to elucidate the mechanisms on the basis of age-related and degenerative disorders. The aim of this review is to summarize and update the most recent knowledge about brain aging through a comparative approach, where similarities and differences in some mammalian species are considered.
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- 2024
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6. Albinism and Blood Cell Profile: The Peculiar Case of Asinara Donkeys
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Maria Grazia Cappai, Alice Senes, and Giovannantonio Pilo
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albino ,anemia ,anisocytosis ,antioxidant ,equine ,erythrocyte ,Veterinary medicine ,SF600-1100 ,Zoology ,QL1-991 - Abstract
The complete blood cell count (CBC) was screened in a group of 15 donkeys, of which 8 were of Asinara breed (oculocutaneous albinism type 1, OCA1) and 7 of Sardo breed (gray coat). All donkeys were kept under same management and dietary conditions and underwent periodic health monitoring in the month of June 2024, at the peak of the positive photoperiod, at Mediterranean latitudes. One aliquot of whole blood, drawn from each individual into K2-EDTA containing tubes, was analyzed for the complete blood cell count through an automatic analyzer, within two hours of sampling. Data were analyzed and compared by one-way ANOVA, where the breed was an independent variable. All animals appeared clinically healthy, though mild eosinophilia was observed in Sardo donkeys. The red blood cell line showed peculiar traits for Asinara donkeys, which displayed significantly higher circulating red blood cell numbers than gray coat Sardo donkeys (RBC, 5.19 vs. 3.80 1012/mL ± 0.98 pooled-St. Dev, respectively; p = 0.017). RBCs also exhibited a smaller diameter and higher degree of anisocytosis in Asinara donkeys, along with lower hematocrit value, albeit within physiological ranges. Taken all together, such hematological profile depicts a peculiar trait of the red blood cell line in albino donkeys during the positive photoperiod.
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- 2024
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7. Are microplastics a new cardiac threat? A pilot study with wild fish from the North East Atlantic Ocean
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Barboza, Luís Gabriel A., Lourenço, Sara Couto, Aleluia, Alexandre, Senes, Giovanni Paolo, Otero, Xosé L., and Guilhermino, Lúcia
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- 2024
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8. Analysis of Proton Bunch Parameters in the AWAKE Experiment
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Hafych, V., Caldwell, A., Agnello, R., Ahdida, C. C., Aladi, M., Goncalves, M. C. Amoedo, Andrebe, Y., Apsimon, O., Apsimon, R., Bachmann, A. -M., Baistrukov, M. A., Batsch, F., Bergamaschi, M., Blanchard, P., Burrows, P. N., Buttenschön, B., Chappell, J., Chevallay, E., Chung, M., Cooke, D. A., Damerau, H., Davut, C., Demeter, G., Dexter, A., Doebert, S., Farmer, J., Fasoli, A., Fedosseev, V. N., Fiorito, R., Fonseca, R. A., Furno, I., Gessner, S., Gorn, A. A., Granados, E., Granetzny, M., Graubner, T., Grulke, O., Gschwendtner, E., Guran, E. D., Henderson, J. R., Hüther, M., Kedves, M. Á., Khudyakov, V., Kim, S. -Y., Kraus, F., Krupa, M., Lefevre, T., Liang, L., Lopes, N., Lotov, K. V., Mazzoni, S., Godoy, D. Medina, Moody, J. T., Moon, K., Guzmán, P. I. Morales, Moreira, M., Nechaeva, T., Nowak, E., Pakuza, C., Panuganti, H., Pardons, A., Perera, A., Pucek, J., Pukhov, A., Ráczkevi, B., Ramjiawan, R. L., Rey, S., Schmitz, O., Senes, E., Silva, L. O., Stollberg, C., Sublet, A., Topaloudis, A., Torrado, N., Tuev, P. V., Turner, M., Velotti, F., Verra, L., Vieira, J., Vincke, H., Welsch, C. P., Wendt, M., Wing, M., Wolfenden, J., Woolley, B., Xia, G., Zepp, M., and Della Porta, G. Zevi
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Physics - Accelerator Physics ,High Energy Physics - Experiment - Abstract
A precise characterization of the incoming proton bunch parameters is required to accurately simulate the self-modulation process in the Advanced Wakefield Experiment (AWAKE). This paper presents an analysis of the parameters of the incoming proton bunches used in the later stages of the AWAKE Run 1 data-taking period. The transverse structure of the bunch is observed at multiple positions along the beamline using scintillating or optical transition radiation screens. The parameters of a model that describes the bunch transverse dimensions and divergence are fitted to represent the observed data using Bayesian inference. The analysis is tested on simulated data and then applied to the experimental data.
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- 2021
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9. A metagenomic study of antibiotic resistance genes in a hypereutrophic subtropical lake contaminated by anthropogenic sources
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Díaz-Torres, Osiris, los Cobos, Eric Oswaldo Valencia-de, Kreft, Jan-Ulrich, Loge, Frank J., Díaz-Vázquez, Diego, Mahlknecht, Jürgen, Gradilla-Hernández, Misael Sebastián, and Senés-Guerrero, Carolina
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- 2024
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10. Complications of left bundle branch area pacing compared with biventricular pacing in candidates for resynchronization therapy: Results of a propensity score–matched analysis from a multicenter registry
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Palmisano, Pietro, Dell’Era, Gabriele, Guerra, Federico, Ammendola, Ernesto, Ziacchi, Matteo, Laffi, Mattia, Donateo, Paolo, Guido, Alessandro, Ghiglieno, Chiara, Parlavecchio, Antonio, Dello Russo, Antonio, Nigro, Gerardo, Biffi, Mauro, Gaggioli, Germano, Senes, Jacopo, Patti, Giuseppe, Accogli, Michele, and Coluccia, Giovanni
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- 2024
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11. Simulation and Experimental Study of Proton Bunch Self-Modulation in Plasma with Linear Density Gradients
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Guzmán, P. I. Morales, Muggli, P., Agnello, R., Ahdida, C. C., Aladi, M., Goncalves, M. C. Amoedo, Andrebe, Y., Apsimon, O., Apsimon, R., Bachmann, A. -M., Baistrukov, M. A., Batsch, F., Bergamaschi, M., Blanchard, P., Braunmüller, F., Burrows, P. N., Buttenschön, B., Caldwell, A., Chappell, J., Chevallay, E., Chung, M., Cooke, D. A., Damerau, H., Davut, C., Demeter, G., Dexter, A., Doebert, S., Farmer, J., Fasoli, A., Fedosseev, V. N., Fiorito, R., Fonseca, R. A., Furno, I., Gessner, S., Gorn, A. A., Granados, E., Granetzny, M., Graubner, T., Grulke, O., Gschwendtner, E., Guran, E. D., Hafych, V., Henderson, J. R., Hüther, M., Kedves, M. Á., Khudyakov, V., Kim, S. -Y., Kraus, F., Krupa, M., Lefevre, T., Liang, L., Lopes, N., Lotov, K. V., Martyanov, M., Mazzoni, S., Godoy, D. Medina, Moody, J. T., Moon, K., Moreira, M., Nechaeva, T., Nowak, E., Pakuza, C., Panuganti, H., Pardons, A., Perera, A., Pucek, J., Pukhov, A., Ráczkevi, B., Ramjiawan, R. L., Rey, S., Schmitz, O., Senes, E., Silva, L. O., Stollberg, C., Sublet, A., Topaloudis, A., Torrado, N., Tuev, P. V., Turner, M., Velotti, F., Verra, L., Vieira, J., Vincke, H., Welsch, C. P., Wendt, M., Wing, M., Wolfenden, J., Woolley, B., Xia, G., Zepp, M., and Della Porta, G. Zevi
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Physics - Plasma Physics ,Physics - Accelerator Physics - Abstract
We present numerical simulations and experimental results of the self-modulation of a long proton bunch in a plasma with linear density gradients along the beam path. Simulation results agree with the experimental results reported in arXiv:2007.14894v2: with negative gradients, the charge of the modulated bunch is lower than with positive gradients. In addition, the bunch modulation frequency varies with gradient. Simulation results show that dephasing of the wakefields with respect to the relativistic protons along the plasma is the main cause for the loss of charge. The study of the modulation frequency reveals details about the evolution of the self-modulation process along the plasma. In particular for negative gradients, the modulation frequency across time-resolved images of the bunch indicates the position along the plasma where protons leave the wakefields. Simulations and experimental results are in excellent agreement., Comment: 13 pages, 11 figures
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- 2021
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12. Selective electron beam sensing through coherent Cherenkov diffraction radiation
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E. Senes, M. Krupa, S. Mazzoni, K. Lasocha, T. Lefevre, A. Schloegelhofer, M. Wendt, C. Davut, P. Karataev, C. Pakuza, and B. Spear
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Physics ,QC1-999 - Abstract
We exploit the coherent emission of Cherenkov diffraction radiation (ChDR) by a relativistic electron beam to sense its position even in the presence of other particle beams. ChDR is produced in alumina inserts embedded in the vacuum chamber walls and recorded in a narrow band centered at 30 GHz. This nontrivial solution has been implemented for plasma wakefield accelerators, where the electron beam to be sensed can copropagate with another high-energy proton beam that generates the plasma wakefield. In addition, at variance with most existing position detectors, this method is insensitive to spurious electric charges due to the presence of plasma. We present the overall design of the detector as well as experimental results obtained in the AWAKE facility at CERN.
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- 2024
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13. Transition between Instability and Seeded Self-Modulation of a Relativistic Particle Bunch in Plasma
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Batsch, F., Muggli, P., Agnello, R., Ahdida, C. C., Goncalves, M. C. Amoedo, Andrebe, Y., Apsimon, O., Apsimon, R., Bachmann, A. -M., Baistrukov, M. A., Blanchard, P., Braunmüller, F., Burrows, P. N., Buttenschön, B., Caldwell, A., Chappell, J., Chevallay, E., Chung, M., Cooke, D. A., Damerau, H., Davut, C., Demeter, G., Deubner, H. L., Doebert, S., Farmer, J., Fasoli, A., Fedosseev, V. N., Fiorito, R., Fonseca, R. A., Friebel, F., Furno, I., Garolfi, L., Gessner, S., Gorgisyan, I., Gorn, A. A., Granados, E., Granetzny, M., Graubner, T., Grulke, O., Gschwendtner, E., Hafych, V., Helm, A., Henderson, J. R., Hüther, M., Kargapolov, I. Yu., Kim, S. -Y., Kraus, F., Krupa, M., Lefevre, T., Liang, L., Liu, S., Lopes, N., Lotov, K. V., Martyanov, M., Mazzoni, S., Godoy, D. Medina, Minakov, V. A., Moody, J. T., Moon, K., Guzmán, P. I. Morales, Moreira, M., Nechaeva, T., Nowak, E., Pakuza, C., Panuganti, H., Pardons, A., Perera, A., Pucek, J., Pukhov, A., Ramjiawan, R. L., Rey, S., Rieger, K., Schmitz, O., Senes, E., Silva, L. O., Speroni, R., Spitsyn, R. I., Stollberg, C., Sublet, A., Topaloudis, A., Torrado, N., Tuev, P. V., Turner, M., Velotti, F., Verra, L., Verzilov, V. A., Vieira, J., Vincke, H., Welsch, C. P., Wendt, M., Wing, M., Wiwattananon, P., Wolfenden, J., Woolley, B., Xia, G., Zepp, M., and Della Porta, G. Zevi
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Physics - Plasma Physics ,Physics - Accelerator Physics - Abstract
We use a relativistic ionization front to provide various initial transverse wakefield amplitudes for the self-modulation of a long proton bunch in plasma. We show experimentally that, with sufficient initial amplitude ($\ge(4.1\pm0.4)$ MV/m), the phase of the modulation along the bunch is reproducible from event to event, with 3 to 7% (of 2$\pi$) rms variations all along the bunch. The phase is not reproducible for lower initial amplitudes. We observe the transition between these two regimes. Phase reproducibility is essential for deterministic external injection of particles to be accelerated., Comment: Letter and Supplemental Material, 6 figures, 8 pages
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- 2020
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14. Pediatric Hand Fractures
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Senes, Filippo M., Nasto, Luigi A., Catena, Nunzio, Arrigoni, Chiara, and Pajardi, Giorgio, editor
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- 2023
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15. Nerve Injuries
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Senes, Filippo M., Catena, Nunzio, Nasto, Luigi A., Arrigoni, Chiara, and Pajardi, Giorgio, editor
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- 2023
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16. Palliative Surgery in Obstetrical Brachial Plexus Palsy
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Senes, Filippo M., Catena, Nunzio, Arrigoni, Chiara, and Pajardi, Giorgio, editor
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- 2023
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17. Experimental study of extended timescale dynamics of a plasma wakefield driven by a self-modulated proton bunch
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Chappell, J., Adli, E., Agnello, R., Aladi, M., Andrebe, Y., Apsimon, O., Apsimon, R., Bachmann, A. -M., Baistrukov, M. A., Batsch, F., Bergamaschi, M., Blanchard, P., Burrows, P. N., Buttenschön, B., Caldwell, A., Chevallay, E., Chung, M., Cooke, D. A., Damerau, H., Davut, C., Demeter, G., Deubner, L. H., Dexter, A., Djotyan, G. P., Doebert, S., Farmer, J., Fasoli, A., Fedosseev, V. N., Fiorito, R., Fonseca, R. A., Friebel, F., Turno, I., Garolfi, L., Gessner, S., Goddard, B., Gorgisyan, I., Gorn, A. A., Granados, E., Granetzny, M., Grulke, O., Gschwendtner, E., Hafych, V., Hartin, A., Helm, A., Henderson, J. R., Howling, A., Hüther, M., Jacquier, R., Jolly, S., Kargapolov, I. Yu., Kedves, M. Á., Keeble, F., Kelisani, M. D., Kim, S. -Y., Kraus, F., Krupa, M., Lefevre, T., Li, Y., Liang, L., Liu, S., Lopes, N., Lotov, K. V., Martyanov, M., Mazzoni, S., Godoy, D. Medina, Minakov, V. A., Moody, J. T., Guzmán, P. I. Morales, Moreira, M., Panuganti, H., Pardons, A., Asmus, F. Peña, Perera, A., Petrenko, A., Pucek, J., Pukhov, A., Ráczkevi, B., Ramjiawan, R. L., Rey, S., Ruhl, H., Saberi, H., Schmitz, O., Senes, E., Sherwood, P., Silva, L. O., Spitsyn, R. I., Tuev, P. V., Velotti, F., Verra, L., Verzilov, V. A., Vieira, J., Welsch, C. P., Williamson, B., Wing, M., Wolfenden, J., Woolley, B., Dia, G., Zepp, M., and Della Porta, G. Zevi
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Physics - Plasma Physics ,Physics - Accelerator Physics - Abstract
Plasma wakefield dynamics over timescales up to 800 ps, approximately 100 plasma periods, are studied experimentally at the Advanced Wakefield Experiment (AWAKE). The development of the longitudinal wakefield amplitude driven by a self-modulated proton bunch is measured using the external injection of witness electrons that sample the fields. In simulation, resonant excitation of the wakefield causes plasma electron trajectory crossing, resulting in the development of a potential outside the plasma boundary as electrons are transversely ejected. Trends consistent with the presence of this potential are experimentally measured and their dependence on wakefield amplitude are studied via seed laser timing scans and electron injection delay scans., Comment: 11 pages, 8 figures
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- 2020
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18. Proton beam defocusing in AWAKE: comparison of simulations and measurements
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Gorn, A. A., Turner, M., Adli, E., Agnello, R., Aladi, M., Andrebe, Y., Apsimon, O., Apsimon, R., Bachmann, A. -M., Baistrukov, M. A., Batsch, F., Bergamaschi, M., Blanchard, P., Burrows, P. N., Buttenschon, B., Caldwell, A., Chappell, J., Chevallay, E., Chung, M., Cooke, D. A., Damerau, H., Davut, C., Demeter, G., Deubner, L. H., Dexter, A., Djotyan, G. P., Doebert, S., Farmer, J., Fasoli, A., Fedosseev, V. N., Fiorito, R., Fonseca, R. A., Friebel, F., Furno, I., Garolfi, L., Gessner, S., Goddard, B., Gorgisyan, I., Granados, E., Granetzny, M., Grulke, O., Gschwendtner, E., Hafych, V., Hartin, A., Helm, A., Henderson, J. R., Howling, A., Huther, M., Jacquier, R., Kargapolov, I. Yu., Kedves, M. A., Keeble, F., Kelisani, M. D., Kim, S. -Y., Kraus, F., Krupa, M., Lefevre, T., Liang, L., Liu, S., Lopes, N., Lotov, K. V., Martyanov, M., Mazzoni, S., Godoy, D. Medina, Minakov, V. A., Moody, J. T., Guzman, P. I. Morales, Moreira, M., Nechaeva, T., Panuganti, H., Pardons, A., Asmus, F. Pena, Perera, A., Petrenko, A., Pucek, J., Pukhov, A., Raczkevi, B., Ramjiawan, R. L., Rey, S., Ruhl, H., Saberi, H., Schmitz, O., Senes, E., Sherwood, P., Silva, L. O., Spitsyn, R. I., Tuev, P. V., Velotti, F., Verra, L., Verzilov, V. A., Vieira, J., Welsch, C. P., Williamson, B., Wing, M., Wolfenden, J., Woolley, B., Xia, G., Zepp, M., and Della Porta, G. Zevi
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Physics - Accelerator Physics ,Physics - Plasma Physics - Abstract
In 2017, AWAKE demonstrated the seeded self-modulation (SSM) of a 400 GeV proton beam from the Super Proton Synchrotron (SPS) at CERN. The angular distribution of the protons deflected due to SSM is a quantitative measure of the process, which agrees with simulations by the two-dimensional (axisymmetric) particle-in-cell code LCODE. Agreement is achieved for beam populations between $10^{11}$ and $3 \times 10^{11}$ particles, various plasma density gradients ($-20 \div 20\%$) and two plasma densities ($2\times 10^{14} \text{cm}^{-3}$ and $7 \times 10^{14} \text{cm}^{-3}$). The agreement is reached only in the case of a wide enough simulation box (at least five plasma wavelengths)., Comment: 8 pages, 9 figures, 1 table
- Published
- 2020
19. Implementation of anaerobic digestion for valorizing the organic fraction of municipal solid waste in developing countries: Technical insights from a systematic review
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Ibarra-Esparza, Fernanda E., González-López, Martín Esteban, Ibarra-Esparza, Juanpablo, Lara-Topete, Gary Ossmar, Senés-Guerrero, Carolina, Cansdale, Annabel, Forrester, Sarah, Chong, James P.J., and Gradilla-Hernández, Misael Sebastián
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- 2023
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20. Development of a beam position monitor for co-propagating electron and proton beams
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Senes, Eugenio, Burrows, Philip, Wendt, Manfred, and Krupa, Michal
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539.7 ,Instrumentation ,Physics - Abstract
Novel acceleration technologies promise a large improvement in particle accelerator performance, but pose a number of technical challenges due to the use of several beams and the beam parameters involved. To exploit these new technologies, these technical challenges need to be addressed. Innovative beam instrumentation is to be devised, to allow these acceleration experiments to become operational accelerators. The AWAKE experiment at CERN aims to develop proton beam-driven plasma wakefield acceleration, with the aim of producing high brightness and high energy particle beams for particle physics research. At AWAKE, plasma wakefields are excited by means of a 400 GeV proton beam driver, and used to accelerate an electron witness beam. The plasma is formed by ionising a Rubidium gas with a terawatt laser pulse. The laser, electron and proton beams co-propagate in the same beampipe for metres before entering the plasma. The electron beam diagnostic is obfuscated by the presence of the more intense proton beam. Consequently, the electron beam position cannot be measured in the presence of the proton beam. To drive the acceleration efficiently, a precise positioning of the three beams is crucial. Therefore, a technique to measure the electron beam position in the presence of the stronger proton beam has to be studied. This work addresses the beam position measurement when more than one beam is present in the beampipe. For the case of AWAKE, a technique to measure the electron-beam position exploiting the bunch-length difference with the proton beam is described. It is shown that the electron-position measurement can be carried out, provided that the detection frequency is sufficiently high. In the second part, a novel beam-position-measurement device, capable of working in the required frequency regime, is developed. Such a device is based on the emission of Cherenkov Diffraction Radiation from dielectric inserts in the beampipe. Electromagnetic simulations of the device are shown, together with the results of experimental tests on a prototype. Further developments to produce an operational instrument are discussed. The potential applications of this technology are not only in plasma-acceleration schemes, but also in any accelerator that uses short bunches, e.g. Free Electron Lasers.
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- 2021
21. The Compact Linear Collider (CLIC) - 2018 Summary Report
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CLIC, The, collaborations, CLICdp, Charles, T. K., Giansiracusa, P. J., Lucas, T. G., Rassool, R. P., Volpi, M., Balazs, C., Afanaciev, K., Makarenko, V., Patapenka, A., Zhuk, I., Collette, C., Boland, M. J., Hoffman, A. C. Abusleme, Diaz, M. A., Garay, F., Chi, Y., He, X., Pei, G., Pei, S., Shu, G., Wang, X., Zhang, J., Zhao, F., Zhou, Z., Chen, H., Gao, Y., Huang, W., Kuang, Y. P., Li, B., Li, Y., Meng, X., Shao, J., Shi, J., Tang, C., Wang, P., Wu, X., Zha, H., Ma, L., Han, Y., Fang, W., Gu, Q., Huang, D., Huang, X., Tan, J., Wang, Z., Zhao, Z., Uggerhøj, U. I., Wistisen, T. N., Aabloo, A., Aare, R., Kuppart, K., Vigonski, S., Zadin, V., Aicheler, M., Baibuz, E., Brücken, E., Djurabekova, F., Eerola, P., Garcia, F., Haeggström, E., Huitu, K., Jansson, V., Kassamakov, I., Kimari, J., Kyritsakis, A., Lehti, S., Meriläinen, A., Montonen, R., Nordlund, K., Österberg, K., Saressalo, A., Väinölä, J., Veske, M., Farabolini, W., Mollard, A., Peauger, F., Plouin, J., Bambade, P., Chaikovska, I., Chehab, R., Delerue, N., Davier, M., Faus-Golfe, A., Irles, A., Kaabi, W., LeDiberder, F., Pöschl, R., Zerwas, D., Aimard, B., Balik, G., Blaising, J. -J., Brunetti, L., Chefdeville, M., Dominjon, A., Drancourt, C., Geoffroy, N., Jacquemier, J., Jeremie, A., Karyotakis, Y., Nappa, J. M., Serluca, M., Vilalte, S., Vouters, G., Bernhard, A., Bründermann, E., Casalbuoni, S., Hillenbrand, S., Gethmann, J., Grau, A., Huttel, E., Müller, A. -S., Peiffer, P., Perić, I., de Jauregui, D. Saez, Emberger, L., Graf, C., Simon, F., Szalay, M., van der Kolk, N., Brass, S., Kilian, W., Alexopoulos, T., Apostolopoulos, T., Gazis, E. N., Gazis, N., Kostopoulos, V., Kourkoulis, S., Heilig, B., Lichtenberger, J., Shrivastava, P., Dayyani, M. K., Ghasem, H., Hajari, S. S., Shaker, H., Ashkenazy, Y., Popov, I., Engelberg, E., Yashar, A., Abramowicz, H., Benhammou, Y., Borysov, O., Borysova, M., Levy, A., Levy, I., Alesini, D., Bellaveglia, M., Buonomo, B., Cardelli, A., Diomede, M., Ferrario, M., Gallo, A., Ghigo, A., Giribono, A., Piersanti, L., Stella, A., Vaccarezza, C., de Blas, J., Franceschini, R., D'Auria, G., Di Mitri, S., Abe, T., Aryshev, A., Fukuda, M., Furukawa, K., Hayano, H., Higashi, Y., Higo, T., Kubo, K., Kuroda, S., Matsumoto, S., Michizono, S., Naito, T., Okugi, T., Shidara, T., Tauchi, T., Terunuma, N., Urakawa, J., Yamamoto, A., Raboanary, R., Luiten, O. J., Stragier, X. F. D., Hart, R., van der Graaf, H., Eigen, G., Adli, E., Lindstrøm, C. A., Lillestøl, R., Malina, L., Pfingstner, J., Sjobak, K. N., Ahmad, A., Hoorani, H., Khan, W. A., Bugiel, S., Bugiel, R., Firlej, M., Fiutowski, T. A., Idzik, M., Moroń, J., Świentek, K. P., de Renstrom, P. Brückman, Krupa, B., Kucharczyk, M., Lesiak, T., Pawlik, B., Sopicki, P., Turbiarz, B., Wojtoń, T., Zawiejski, L. K., Kalinowski, J., Nowak, K., Żarnecki, A. F., Firu, E., Ghenescu, V., Neagu, A. T., Preda, T., Zgura, I. S., Aloev, A., Azaryan, N., Boyko, I., Budagov, J., Chizhov, M., Filippova, M., Glagolev, V., Gongadze, A., Grigoryan, S., Gudkov, D., Karjavine, V., Lyablin, M., Nefedov, Yu., Olyunin, A., Rymbekova, A., Samochkine, A., Sapronov, A., Shelkov, G., Shirkov, G., Soldatov, V., Solodko, E., Trubnikov, G., Tyapkin, I., Uzhinsky, V., Vorozhtov, A., Zhemchugov, A., Levichev, E., Mezentsev, N., Piminov, P., Shatilov, D., Vobly, P., Zolotarev, K., Jelisavčić, I. Božović, Kačarević, G., Dumbelović, G. Milutinović, Pandurović, M., Radulović, M., Stevanović, J., Vukasinović, N., Lee, D. -H., Ayala, N., Benedetti, G., Guenzel, T., Iriso, U., Marti, Z., Perez, F., Pont, M., Trenado, J., Ruiz-Jimeno, A., Vila, I., Calero, J., Dominguez, M., Garcia-Tabares, L., Gavela, D., Lopez, D., Toral, F., Gutierrez, C. Blanch, Boronat, M., Esperante, D., Fullana, E., Fuster, J., García, I., Gimeno, B., Lopez, P. Gomis, González, D., Perelló, M., Ros, E., Villarejo, M. A., Vnuchenko, A., Vos, M., Borgmann, Ch., Brenner, R., Ekelöf, T., Jacewicz, M., Olvegård, M., Ruber, R., Ziemann, V., Aguglia, D., Gonzalvo, J. Alabau, Leon, M. Alcaide, Tehrani, N. Alipour, Anastasopoulos, M., Andersson, A., Andrianala, F., Antoniou, F., Apyan, A., Arominski, D., Artoos, K., Assly, S., Atieh, S., Baccigalupi, C., Sune, R. Ballabriga, Caballero, D. Banon, Barnes, M. J., Garcia, J. Barranco, Bartalesi, A., Bauche, J., Bayar, C., Belver-Aguilar, C., Morell, A. Benot, Bernardini, M., Bett, D. R., Bettoni, S., Bettencourt, M., Bielawski, B., Garcia, O. Blanco, Kraljevic, N. Blaskovic, Bolzon, B., Bonnin, X. A., Bozzini, D., Branger, E., Brondolin, E., Brunner, O., Buckland, M., Bursali, H., Burkhardt, H., Caiazza, D., Calatroni, S., Campbell, M., Lasheras, N. Catalan, Cassany, B., Castro, E., Soares, R. H. Cavaleiro, Bastos, M. Cerqueira, Cherif, A., Chevallay, E., Cilento, V., Corsini, R., Costa, R., Cure, B., Curt, S., Gobbo, A. Dal, Dannheim, D., Daskalaki, E., Deacon, L., Degiovanni, A., De Michele, G., De Oliveira, L., Romano, V. Del Pozo, Delahaye, J. P., Delikaris, D., de Almeida, P. G. Dias, Dobers, T., Doebert, S., Doytchinov, I., Draper, M., Ramos, F. Duarte, Duquenne, M., Plaja, N. Egidos, Elsener, K., Esberg, J., Esposito, M., Evans, L., Fedosseev, V., Ferracin, P., Fiergolski, A., Foraz, K., Fowler, A., Friebel, F., Fuchs, J-F., Gaddi, A., Gamba, D., Fajardo, L. Garcia, Morales, H. Garcia, Garion, C., Gasior, M., Gatignon, L., Gayde, J-C., Gerbershagen, A., Gerwig, H., Giambelli, G., Gilardi, A., Goldblatt, A. N., Anton, S. Gonzalez, Grefe, C., Grudiev, A., Guerin, H., Guillot-Vignot, F. G., Gutt-Mostowy, M. L., Lutz, M. Hein, Hessler, C., Holma, J. K., Holzer, E. B., Hourican, M., Hynds, D., Ikarios, E., Levinsen, Y. Inntjore, Janssens, S., Jeff, A., Jensen, E., Jonker, M., Kamugasa, S. W., Kastriotou, M., Kemppinen, J. M. K., Khan, V., Kieffer, R. B., Klempt, W., Kokkinis, N., Kossyvakis, I., Kostka, Z., Korsback, A., Platia, E. Koukovini, Kovermann, J. W., Kozsar, C-I., Kremastiotis, I., Kröger, J., Kulis, S., Latina, A., Leaux, F., Lebrun, P., Lefevre, T., Leogrande, E., Linssen, L., Liu, X., Cudie, X. Llopart, Magnoni, S., Maidana, C., Maier, A. A., Durand, H. Mainaud, Mallows, S., Manosperti, E., Marelli, C., Lacoma, E. Marin, Marsh, S., Martin, R., Martini, I., Martyanov, M., Mazzoni, S., Mcmonagle, G., Mether, L. M., Meynier, C., Modena, M., Moilanen, A., Mondello, R., Cabral, P. B. Moniz, Irazabal, N. Mouriz, Munker, M., Muranaka, T., Nadenau, J., Navarro, J. G., Quirante, J. L. Navarro, Del Busto, E. Nebo, Nikiforou, N., Ninin, P., Nonis, M., Nisbet, D., Nuiry, F. X., Nürnberg, A., Ögren, J., Osborne, J., Ouniche, A. C., Pan, R., Papadopoulou, S., Papaphilippou, Y., Paraskaki, G., Pastushenko, A., Passarelli, A., Patecki, M., Pazdera, L., Pellegrini, D., Pepitone, K., Codina, E. Perez, Fontenla, A. Perez, Persson, T. H. B., Petrič, M., Pitman, S., Pitters, F., Pittet, S., Plassard, F., Popescu, D., Quast, T., Rajamak, R., Redford, S., Remandet, L., Renier, Y., Rey, S. F., Orozco, O. Rey, Riddone, G., Castro, E. Rodriguez, Roloff, P., Rossi, C., Rossi, F., Rude, V., Ruehl, I., Rumolo, G., Sailer, A., Sandomierski, J., Santin, E., Sanz, C., Bedolla, J. Sauza, Schnoor, U., Schmickler, H., Schulte, D., Senes, E., Serpico, C., Severino, G., Shipman, N., Sicking, E., Simoniello, R., Skowronski, P. K., Mompean, P. Sobrino, Soby, L., Sollander, P., Solodko, A., Sosin, M. P., Spannagel, S., Sroka, S., Stapnes, S., Sterbini, G., Stern, G., Ström, R., Stuart, M. J., Syratchev, I., Szypula, K., Tecker, F., Thonet, P. A., Thrane, P., Timeo, L., Tiirakari, M., Garcia, R. Tomas, Tomoiaga, C. I., Valerio, P., Vaňát, T., Vamvakas, A. L., Van Hoorne, J., Viazlo, O., Pinto, M. Vicente Barreto, Vitoratou, N., Vlachakis, V., Weber, M. A., Wegner, R., Wendt, M., Widorski, M., Williams, O. E., Williams, M., Woolley, B., Wuensch, W., Wulzer, A., Uythoven, J., Xydou, A., Yang, R., Zelios, A., Zhao, Y., Zisopoulos, P., Benoit, M., Sultan, D M S, Riva, F., Bopp, M., Braun, H. H., Craievich, P., Dehler, M., Garvey, T., Pedrozzi, M., Raguin, J. Y., Rivkin, L., Zennaro, R., Guillaume, S., Rothacher, M., Aksoy, A., Nergiz, Z., Yavas, Ö., Denizli, H., Keskin, U., Oyulmaz, K. Y., Senol, A., Ciftci, A. K., Baturin, V., Karpenko, O., Kholodov, R., Lebed, O., Lebedynskyi, S., Mordyk, S., Musienko, I., Profatilova, Ia., Storizhko, V., Bosley, R. R., Price, T., Watson, M. F., Watson, N. K., Winter, A. G., Goldstein, J., Green, S., Marshall, J. S., Thomson, M. A., Xu, B., You, T., Gillespie, W. A., Spannowsky, M., Beggan, C., Martin, V., Zhang, Y., Protopopescu, D., Robson, A., Apsimon, R. J., Bailey, I., Burt, G. C., Dexter, A. C., Edwards, A. V., Hill, V., Jamison, S., Millar, W. L., Papke, K., Casse, G., Vossebeld, J., Aumeyr, T., Bergamaschi, M., Bobb, L., Bosco, A., Boogert, S., Boorman, G., Cullinan, F., Gibson, S., Karataev, P., Kruchinin, K., Lekomtsev, K., Lyapin, A., Nevay, L., Shields, W., Snuverink, J., Towler, J., Yamakawa, E., Boisvert, V., West, S., Jones, R., Joshi, N., Bett, D., Bodenstein, R. M., Bromwich, T., Burrows, P. N., Christian, G. B., Gohil, C., Korysko, P., Paszkiewicz, J., Perry, C., Ramjiawan, R., Roberts, J., Coates, T., Salvatore, F., Bainbridge, A., Clarke, J. A., Krumpa, N., Shepherd, B. J. A., Walsh, D., Chekanov, S., Demarteau, M., Gai, W., Liu, W., Metcalfe, J., Power, J., Repond, J., Weerts, H., Xia, L., Zupan, J., Wells, J. D., Zhang, Z., Adolphsen, C., Barklow, T., Dolgashev, V., Franzi, M., Graf, N., Hewett, J., Kemp, M., Kononenko, O., Markiewicz, T., Moffeit, K., Neilson, J., Nosochkov, Y., Oriunno, M., Phinney, N., Rizzo, T., Tantawi, S., Wang, J., Weatherford, B., White, G., and Woodley, M.
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Physics - Accelerator Physics - Abstract
The Compact Linear Collider (CLIC) is a TeV-scale high-luminosity linear $e^+e^-$ collider under development at CERN. Following the CLIC conceptual design published in 2012, this report provides an overview of the CLIC project, its current status, and future developments. It presents the CLIC physics potential and reports on design, technology, and implementation aspects of the accelerator and the detector. CLIC is foreseen to be built and operated in stages, at centre-of-mass energies of 380 GeV, 1.5 TeV and 3 TeV, respectively. CLIC uses a two-beam acceleration scheme, in which 12 GHz accelerating structures are powered via a high-current drive beam. For the first stage, an alternative with X-band klystron powering is also considered. CLIC accelerator optimisation, technical developments and system tests have resulted in an increased energy efficiency (power around 170 MW) for the 380 GeV stage, together with a reduced cost estimate at the level of 6 billion CHF. The detector concept has been refined using improved software tools. Significant progress has been made on detector technology developments for the tracking and calorimetry systems. A wide range of CLIC physics studies has been conducted, both through full detector simulations and parametric studies, together providing a broad overview of the CLIC physics potential. Each of the three energy stages adds cornerstones of the full CLIC physics programme, such as Higgs width and couplings, top-quark properties, Higgs self-coupling, direct searches, and many precision electroweak measurements. The interpretation of the combined results gives crucial and accurate insight into new physics, largely complementary to LHC and HL-LHC. The construction of the first CLIC energy stage could start by 2026. First beams would be available by 2035, marking the beginning of a broad CLIC physics programme spanning 25-30 years., Comment: 112 pages, 59 figures; published as CERN Yellow Report Monograph Vol. 2/2018; corresponding editors: Philip N. Burrows, Nuria Catalan Lasheras, Lucie Linssen, Marko Petri\v{c}, Aidan Robson, Daniel Schulte, Eva Sicking, Steinar Stapnes
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- 2018
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22. Congenital Dislocation of the Shoulder
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Catena, Nunzio, Senes, Filippo M., and Farr, Sebastian, editor
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- 2022
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23. Lugar de mulher é onde ela quiser
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Senes, Gabrielly Giovana Pereira, primary, Braz, Bárbara Cândido, additional, and Barros, Michele Carvalho de Barros, additional
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- 2022
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24. Rate and nature of complications of conduction system pacing compared with right ventricular pacing: results of a propensity-matched analysis from a multicentre registry
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Palmisano, Pietro, Ziacchi, Matteo, Dell’Era, Gabriele, Donateo, Paolo, Ammendola, Ernesto, Coluccia, Giovanni, Guido, Alessandro, Piemontese, Giuseppe Pio, Lazzeri, Mirco, Ghiglieno, Chiara, Veroli, Alessandro, Maggio, Roberto, Russo, Vincenzo, Rago, Anna, Nigro, Gerardo, Senes, Jacopo, Patti, Giuseppe, Biffi, Mauro, and Accogli, Michele
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- 2023
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25. Assessment of the ecosystem services given by rural and urban green areas to preserve high quality territories from land take: the case of the Province of Monza Brianza (Italy)
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Giulio Senes, Natalia Fumagalli, Paolo Stefano Ferrario, Roberto Rovelli, Federico Riva, Giovanna Sacchi, Paolo Gamba, Giacomo Ruffini, and Giacomo Redondi
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Ecosystem services ,rural and urban green areas ,land take ,Agriculture ,Agriculture (General) ,S1-972 - Abstract
Rural and urban green areas are essential territories that support life and ecosystems. The significant reduction of these areas, due to the urbanization is a pressing issue. The process of land take not only consumes land resources but also the connected ecosystems and the benefits generated for the human society. Reducing the quantity of land taken is imperative but preserving high quality territories is essential to achieving sustainable development. Evaluating the quality of non-urbanized areas can be performed by assessing the Ecosystem Services (ESs) provided by these areas. In this paper, the authors present a further step, an evolution and deepening, of the previous methodology (published in 2020) for evaluating the quality of rural and urban green areas through the assessment of Ecosystem Services provided. The methodology first allows the identification of the ESs provided by different typologies of rural and urban green areas according to the CICES - Common International Classification of Ecosystem Services (provisioning, regulation and maintenance, and cultural). Then, it allows the calculation of several singular indexes and a final Composite Quality Index (CQI) through the use of GIS (Geographical Information Systems). An Analytic Hierarchy Process (AHP) was performed with the creation of different scenarios to consider the different importance of the singular indexes assigned by planners and communities involved. The methodology was applied to the Province of Monza Brianza (Italy) for testing and validation purposes. The application to the Municipality of Sovico, which is presented in this report, allowed for the identification of areas with higher quality in the different scenarios that were created to consider the relative importance of the territorial characteristics.
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- 2023
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26. Comparison of long-term risk of device-related complications between left bundle branch area pacing and biventricular pacing in candidates for resynchronization therapy
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Coluccia, G, primary, Ziacchi, M, additional, Dell'era, G, additional, Donateo, P, additional, Ammendola, E, additional, Aspromonte, V, additional, Guido, A, additional, Ghiglieno, C, additional, Parlavecchio, A, additional, Nigro, G, additional, Senes, J, additional, Patti, G, additional, Biffi, M, additional, Accogli, M, additional, and Palmisano, P, additional
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- 2024
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27. Validation of UHPLC-MS/MS Method and Measurement Uncertainty Evaluation for Lactose Quantification in Lactose-Free and Regular UHT Milk
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Chiavelli, Lucas Ulisses Rovigatti, Galuch, Marília Bellanda, Senes, Carlos Eduardo Rubio, Maia, Leonardo Castro, Lopes, Tiago Antonio Marmentini, Rufato, Késsily Barbosa, Santos, Oscar Oliveira, and Visentainer, Jesuí Vergílio
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- 2022
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28. Effect of high CO2 concentrations on Desmodesmus abundans RSM lipidome
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Mora-Godínez, Shirley, Rodríguez-López, Carlos Eduardo, Senés-Guerrero, Carolina, Treviño, Víctor, Díaz de la Garza, Rocío, and Pacheco, Adriana
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- 2022
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29. Perspective Chapter: The Lean Approach in Waste Management. A Case Study
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Pinna, Roberta, primary and Senes, Giovanni, additional
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- 2022
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30. Tumor mesenquimático fosfatúrico de pelvis: abordaje multidisciplinario
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Leonardo Matías Cullari, Sebastián Senes, Juan Pablo Taleb, Ignacio Fita, and Pablo Daniel Sarmiento
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tumor mesenquimático fosfatúrico ,osteomalacia oncogénica ,ortopedia oncológica ,cirugía de pelvis ,Orthopedic surgery ,RD701-811 - Abstract
El tumor mesenquimático fosfatúrico es una entidad clinicopatológica sumamente infrecuente. Además de provocar dolor óseo insidioso y polimialgias, se acompaña de alteraciones del metabolismo fosfocálcico de difícil manejo clínico. El abordaje multidisciplinario resulta la clave del éxito en esta enfermedad. Presentamos una paciente de 52 años de edad con antecedente de tumor mesenquimático fosfatúrico en la hemipelvis derecha con extensión a la cadera homolateral de 10 años de evolución. Clínicamente presentaba osteomalacia oncogénica (hipofosfatemia e hiperfosfaturia) que no se corregía, pese a un agente de última generación, el burosumab, un inhibidor del factor de crecimiento fibroblástico 23, que aumenta la tubular renal de fosfatos. En un comité multidisciplinario, se decidió la resección con márgenes oncológicos y se logró una mejoría clínica franca. Comunicamos este caso, debido a que es un cuadro infrecuente
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- 2022
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31. A review of the sustainability of anaerobic reactors combined with constructed wetlands for decentralized wastewater treatment
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Fernández del Castillo, Alberto, Garibay, Marycarmen Verduzco, Senés-Guerrero, Carolina, Orozco-Nunnelly, Danielle A., de Anda, José, and Gradilla-Hernández, Misael Sebastián
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- 2022
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32. Renoprotective effects of dapagliflozin in an iron overload non-diabetic rat model
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Fırat, Sevde Nur, Kuşkonmaz, Şerife Mehlika, Çaydere, Muzaffer, Şeneş, Mehmet, Hücümenoğlu, Sema, and Çulha, Cavit
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- 2022
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33. Using yeast cultures to valorize tequila vinasse waste: An example of a circular bioeconomy approach in the agro-industrial sector
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Díaz-Vázquez, Diego, Orozco-Nunnelly, Danielle A., Yebra-Montes, Carlos, Senés-Guerrero, Carolina, and Gradilla-Hernández, Misael Sebastián
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- 2022
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34. Microalgae-based livestock wastewater treatment (MbWT) as a circular bioeconomy approach: Enhancement of biomass productivity, pollutant removal and high-value compound production
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López-Sánchez, Anaid, Silva-Gálvez, Ana Laura, Aguilar-Juárez, Óscar, Senés-Guerrero, Carolina, Orozco-Nunnelly, Danielle A., Carrillo-Nieves, Danay, and Gradilla-Hernández, Misael Sebastián
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- 2022
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35. Assessment of the ecosystem services given by rural and urban green areas to preserve high-quality territories from land take: the case of the province of Monza Brianza (Italy).
- Author
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Senes, Giulio, Fumagalli, Natalia, Ferrario, Paolo Stefano, Rovelli, Roberto, Riva, Federico, Sacchi, Giovanna, Gamba, Paolo, Ruffini, Giacomo, and Redondi, Giacomo
- Subjects
- *
ECOSYSTEM services , *ANALYTIC hierarchy process , *GEOGRAPHIC information systems , *PUBLIC spaces , *LAND resource - Abstract
Rural and urban green areas are essential territories that support life and ecosystems. The significant reduction of these areas due to urbanization is a pressing issue. The process of land take consumes not only land resources but also the connected ecosystems and the benefits generated for human society. Reducing the quantity of land taken is imperative, but preserving high-quality territories is essential to achieving sustainable development. Evaluating the quality of non-urbanized areas can be done by assessing the ecosystem services (ESs) provided by these areas. In this paper, the authors present a further step: an evolution and deepening of the previous methodology (published in 2020) to evaluate the quality of rural and urban green areas through the assessment of the ESs provided. The methodology first allows the identification of the ESs provided by different typologies of rural and urban green areas according to the common international classification of ESs (provisioning, regulation and maintenance, and cultural). Then, it allows the calculation of several singular indexes and a final composite quality index through the use of geographical information systems. An analytic hierarchy process was performed with the creation of different scenarios to consider the different importance of the singular indexes assigned by planners and communities involved. The methodology was applied to the province of Monza Brianza (Italy), for testing and validation purposes. The application to the municipality of Sovico, which is presented in this report, allowed for the identification of areas with higher quality in the different scenarios that were created to consider the relative importance of the territorial characteristics. [ABSTRACT FROM AUTHOR]
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- 2024
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36. Morphological and Metabolic Features of Brain Aging in Rodents, Ruminants, Carnivores, and Non-Human Primates.
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Lepore, Gianluca, Succu, Sara, Cappai, Maria Grazia, Frau, Adele, Senes, Alice, Zedda, Marco, Farina, Vittorio, and Gadau, Sergio D.
- Abstract
Simple Summary: Brain aging in mammals is characterized by morphological and functional changes in neural cells. This process, although physiological, leads to progressive cerebral tissue volume loss and functional decline, including memory loss motor neuron deficits and behavioral disorders. It is generally accepted that aging is associated with a shift in the proportion between the functional cell (neuron) and support cells (astrocytes) in favor of the latter, which also appear different from those of healthy and young brain tissue. Also, dysfunctional autophagy contributes to altering brain homeostasis. This review summarizes and updates the most recent knowledge about brain aging through a comparative approach, where similarities and differences in some mammalian species are considered. Brain aging in mammals is characterized by morphological and functional changes in neural cells. Macroscopically, this process, leading to progressive cerebral volume loss and functional decline, includes memory and motor neuron deficits, as well as behavioral disorders. Morphologically, brain aging is associated with aged neurons and astrocytes, appearing enlarged and flattened, and expressing enhanced pH-dependent β-galactosidase activity. Multiple mechanisms are considered hallmarks of cellular senescence in vitro, including cell cycle arrest, increased lysosomal activity, telomere shortening, oxidative stress, and DNA damage. The most common markers for senescence identification were identified in (i) proteins implicated in cell cycle arrest, such as p16, p21, and p53, (ii) increased lysosomal mass, and (iii) increased reactive oxygen species (ROS) and senescence-associated secretory phenotype (SASP) expression. Finally, dysfunctional autophagy, a process occurring during aging, contributes to altering brain homeostasis. The brains of mammals can be studied at cellular and subcellular levels to elucidate the mechanisms on the basis of age-related and degenerative disorders. The aim of this review is to summarize and update the most recent knowledge about brain aging through a comparative approach, where similarities and differences in some mammalian species are considered. [ABSTRACT FROM AUTHOR]
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- 2024
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37. Albinism and Blood Cell Profile: The Peculiar Case of Asinara Donkeys.
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Cappai, Maria Grazia, Senes, Alice, and Pilo, Giovannantonio
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BLOOD cell count , *ERYTHROCYTES , *SOLAR radiation , *SUNSHINE , *MEDITERRANEAN climate - Abstract
Simple Summary: Asinara donkeys are unique worldwide for expressing a particular form of albinism spread to all individuals of the breed. This peculiar condition of oculo-cutaneous albinism of type 1 (OCA1) is a rare condition from a recessive autosomic mutation, fixed through generations, thanks to the isolation of donkeys on Asinara Island (from which the breed name originates) favoring inbreeding. Asinara island is a small island of Sardinia, one of the biggest islands in the Mediterranean sea. Asinara donkeys have shown good adaptation to the Mediterranean climate through various metabolic strategies, one of which relies on endogenous retinol mobilization during the positive photoperiod for protective effect and adequate circulating vitamin E. Indeed, their exposure to sun radiation and high temperature on one hand, and the lack of melanin in the coat, skin, iris and mucocutaneous junctions on the other, require them to overcome such an extended lack of photoprotective pigment (melanin) in alternative ways to prevent UV radiation damage. In this investigation, our interest was oriented toward screening the complete blood cell count to understand whether metabolic adaptation to the environment involved blood cell lines. Such an idea comes from the fact that in humans, a particular condition of albinism is reported to share the same gene with other mutations involving hemoglobin synthesis. In our case, significant differences were observed in relation to red blood cells (RBCs), in terms of their average volume (MCV), width distribution (RDW-CV), and width deviation (RDW-SD), in comparison to pigmented (gray) Sardo donkeys. The complete blood cell count (CBC) was screened in a group of 15 donkeys, of which 8 were of Asinara breed (oculocutaneous albinism type 1, OCA1) and 7 of Sardo breed (gray coat). All donkeys were kept under same management and dietary conditions and underwent periodic health monitoring in the month of June 2024, at the peak of the positive photoperiod, at Mediterranean latitudes. One aliquot of whole blood, drawn from each individual into K2-EDTA containing tubes, was analyzed for the complete blood cell count through an automatic analyzer, within two hours of sampling. Data were analyzed and compared by one-way ANOVA, where the breed was an independent variable. All animals appeared clinically healthy, though mild eosinophilia was observed in Sardo donkeys. The red blood cell line showed peculiar traits for Asinara donkeys, which displayed significantly higher circulating red blood cell numbers than gray coat Sardo donkeys (RBC, 5.19 vs. 3.80 1012/mL ± 0.98 pooled-St. Dev, respectively; p = 0.017). RBCs also exhibited a smaller diameter and higher degree of anisocytosis in Asinara donkeys, along with lower hematocrit value, albeit within physiological ranges. Taken all together, such hematological profile depicts a peculiar trait of the red blood cell line in albino donkeys during the positive photoperiod. [ABSTRACT FROM AUTHOR]
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- 2024
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38. Estimation of genetic parameters for reproductive indices in sheep.
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Senes, Beatriz Bastos, da Cruz, Valdecy Aparecida Rocha, Azevedo, Hymerson Costa, Costa, Raphael Bermal, and de Camargo, Gregório Miguel Ferreira
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ANIMAL weaning , *BIRTH weight , *GENETIC correlations , *BAYESIAN analysis , *BODY weight , *ANIMAL litters - Abstract
This study aimed to estimate two reproductive efficiency indices in sheep based on the ratio between litter weight (at birth and weaning) and dam weight, as well as their genetic parameters. Phenotypic and pedigree data comprising the period from 1990 to 2018 were obtained from the Santa Inês sheep database of Embrapa Tabuleiros Costeiros. For estimation of the genetic parameters of the indices, a repeatability model was applied in single‐ and two‐trait analyses by a Bayesian approach. The mean reproductive efficiency index was 0.069 ± 0.0163 and 0.43 ± 0.0955 at birth and weaning, respectively. These values indicate that, on average, ewes give birth to 69 g of lamb per kg body weight and wean 430 g of lamb per kg body weight. Described here for the first time, the heritability estimate obtained in single‐ and two‐trait analyses was 0.24 for the index based on birth weights and ranged from 0.13 to 0.15 for the index based on weaning weights. The estimates indicate the possibility of genetic gain by selection and are similar to those reported for reproductive traits in sheep, representing an option for selection criterion. The genetic correlation between indices was positive and moderate (0.26). The repeatability estimates were high (0.49 for the birth weight index and 0.71 for the weaning weight index). These values indicate good prediction of future performance with few observations. The weaning weight index might be a good culling criterion of females. [ABSTRACT FROM AUTHOR]
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- 2024
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39. Evaluation of the implementation of the rational use of laboratory tests in the clinical chemistry laboratory.
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Serin, Huriye, Orhan, Bagnu, Say, Merve S., Arslan, Hilmi F., Inal, Sinemis, Inal, Berrin B., and Senes, Mehmet
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- 2024
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40. Thermodynamic analysis of the GASright transmembrane motif supports energetic model of dimerization
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Vázquez, Gladys Díaz, Cui, Qiang, and Senes, Alessandro
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- 2022
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41. 25-hydroxyvitamin D (25-OHD) levels in Turkish geriatric population: A nationwide study
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Çağlayan Murat, Sonmez Cigdem, Senes Mehmet, Gonel Ataman, Gulbahar Ozlem, Bursa Nurbanu, Taner Derun, Celik Osman, Aykut Fidanci Ali, Mahir Ulgu Mustafa, Sozuer Abdulvahit, Ata Naim, and Birinci Suayip
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25-oh vitamin d ,geriatry ,big data ,seasons ,vitamin d deficiency ,sunbathing time ,Biochemistry ,QD415-436 - Abstract
Background: Across the world, 25-hydroxyvitamin D (25-OHD) deficiency is a major health problem associated with many chronic diseases in the geriatric population. Prior to this study, there were no data regarding 25-OHD levels among individuals over the age of 65 in Turkey. The aim of this study was to assess 25-OHD levels and seasonal variations in these values among people over the age of 65 in Turkey. Methods: This study included vitamin D measurements taken in 2016, 2017, and 2018 from the Turkish population over the age of 65. The age, gender, and seasonal average data of the study population were defined. The study data were obtained from the database of the Ministry of Health, and a Kolmogorov-Smirnov test was used to assess the distribution of the data. Medians and interquartile ranges (IQRs) were calculated for all categories, as the data were nonparametric. Results: The number of vitamin D measurements taken from the geriatric individuals included in this study was 305,329 for 2016, 576,452 for 2017, and 752,837 for 2018. The medians and IQRs of the 25-OHD levels in this population were 16 mg/L (IQR 7.45-24.55 mg/L) for 2016, 16.1 mg/L (IQR 7.8-24.4 mg/L) for 2017, and 16.4 mg/L (IQR 8.95-23.85 mg/L) for 2018. Conclusions: While the 25-OHD levels of older men tended to increase during the period of seasonal sunlight in Turkey, this variability was observed in elderly women. This suggests that older women tend to live more sedentary lives and have insufficient sun exposure. Overall, the median 25-OHD levels of individuals over the age of 65 tended to decrease each year.
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- 2022
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42. Clemente Palma, Carlos Toro y el paso del cometa Halley en 1910 : catástrofe, palingenesia y alegoría
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HERRERO-SENÉS, JUAN
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- 2020
43. “Ablate and Pace” with Conduction System Pacing: Concomitant versus Delayed Atrioventricular Junction Ablation
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Palmisano, Pietro, primary, Ziacchi, Matteo, additional, Dell’Era, Gabriele, additional, Donateo, Paolo, additional, Bartoli, Lorenzo, additional, Patti, Giuseppe, additional, Senes, Jacopo, additional, Parlavecchio, Antonio, additional, Biffi, Mauro, additional, Accogli, Michele, additional, and Coluccia, Giovanni, additional
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- 2024
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44. Dietary Fiber and Gut Microbiota
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Senés-Guerrero, Carolina, Gradilla-Hernández, Misael Sebastián, García-Gamboa, Ricardo, García-Cayuela, Tomás, Barbosa-Cánovas, Gustavo V., Series Editor, Aguilera, José Miguel, Advisory Editor, Candoğan, Kezban, Advisory Editor, Hartel, Richard W., Advisory Editor, Ibarz, Albert, Advisory Editor, Peleg, Micha, Advisory Editor, Rahman, Shafiur, Advisory Editor, Rao, M. Anandha, Advisory Editor, Roos, Yrjö, Advisory Editor, Welti-Chanes, Jorge, Advisory Editor, Serna-Saldívar, Sergio O., editor, Campanella, Osvaldo, editor, and Tejada-Ortigoza, Viridiana, editor
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- 2020
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45. MgNb2O6 Modified K0.5Na0.5NbO3 Eco‐Piezoceramics: Scalable Processing, Structural Distortion and Complex Impedance at Resonance
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Antonio Iacomini, Prof. Sebastiano Garroni, Dr. Nina Senes, Prof. Gabriele Mulas, Prof. Stefano Enzo, Matteo Poddighe, Álvaro García, Dr. José F. Bartolomé, and Prof. Lorena Pardo
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lead free compounds ,mechanochemistry ,piezoelectric ceramics ,solid-state synthesis ,sintering additives ,Chemistry ,QD1-999 - Abstract
Abstract In this work, piezoceramics of the lead‐free composition K0.5Na0.5NbO3 with an increasing amount of MgNb2O6 (0, 0.5, 1, 2 wt.%) were prepared through conventional solid‐state synthesis and sintered in air atmosphere at 1100 °C. The effect of magnesium niobate addition on structure, microstructure and piezoelectric properties was evaluated. The ceramics maintain the orthorhombic Amm2 phase for all compositions, while an orthorhombic Pbcm secondary phase was found for increasing the concentration of MgNb2O6. Our results show that densification of these ceramics can be significantly improved up to 94.9 % of theoretical density by adding a small amount of magnesium‐based oxide (1 wt.%). Scanning electron microscopy morphology of the 1 wt.% system reveals a well‐packed structure with homogeneous grain size of ∼2.72 μm. Dielectric and piezoelectric properties become optimal for 0.5–1.0 wt.% of MgNb2O6 that shows, with respect to the unmodified composition, either higher piezoelectric coefficients, lower anisotropy and relatively low piezoelectric losses (d33=97 pC N−1; d31=−36.99 pC N−1 and g31=−14.04×10−3 mV N−1; Qp(d31)=76 and Qp(g31)=69) or enhanced electromechanical coupling factors (kp=29.06 % and k31=17.25 %).
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- 2021
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46. COLLECTIVE ANXIETIES, READER MANIPULATION AND THE 1910 PASSAGE OF HALLEY’S COMET IN RAMÓN MARÍA TENREIRO’S LA AGONÍA DE MADRID
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Herrero-Senés, Juan
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- 2020
47. Visual post-occupancy evaluation of a restorative garden using virtual reality photography: Restoration, emotions, and behavior in older and younger people
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Marco Boffi, Linda Grazia Pola, Elisabetta Fermani, Giulio Senes, Paolo Inghilleri, Barbara Ester Adele Piga, Gabriele Stancato, and Natalia Fumagalli
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healing garden ,older society ,attention restoration ,emotional appraisal ,behavioral effect ,landscape design ,Psychology ,BF1-990 - Abstract
Natural environments have a restorative effect from mental/attentional fatigue, prevent stress, and help to revitalize psychological and physical resources. These benefits are crucial for promoting active aging, which is particularly relevant given the phenomenon of population aging in recent decades. To be considered restorative, green spaces have to meet specific requirements in ecological and psychological terms that can be assessed through Post-Occupancy Evaluation (POE), a multimethod approach commonly used by environmental psychologists and landscape architects after construction to evaluate the design outcomes from the users’ perspective. Generally, POEs consist of surveys and/or interviews accompanied by more or less structured observations of onsite users’ behavior. Despite this, various practical constraints can prevent physical access to the renovated area (e.g., weather conditions, time/resources limits, health issues, bureaucratic constraints). Exploiting digital tools for such an assessment can be a crucial support in such circumstances. The current study presents the visual POE of a restorative garden for older adults in Milan, Italy. We developed a web application, that includes the exp-EIA© patented method, which allows participants to virtually explore a visual simulation of the environment and provide their feedback. We identified 3 representative viewpoints in the redeveloped garden differing from each other for the functions and the design principles that inspired the transformation. For each point of view, we created 360° Virtual Reality photographs, that can be navigated by looking around, i.e., panning, from the standing point of each view. In connection to each virtual scene, a survey was conducted (N = 321). The focus was the psychological experience related to each viewpoint, assessed with two psychometric scales investigating the constructs of emotions (pleasure and arousal) and restoration (fascination, being away, coherence, scope, and environmental preference); such information is integrated with behavioral aspects, including the main activities prefigured by participants and their visual exploration of the VR photography. The results of the virtual exploration show that the garden is perceived as restorative, with a more intense effect in a spot purposely designed. The emotions experienced in the garden are positive and a mild level of arousal is observed. The behavioral dimension is characterized by predominantly contemplative activities and contact with nature. A cartographic representation of the psychological and behavioral data is developed, to support the maintenance of the garden.
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- 2022
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48. Pseudobombax parvifolium Hydroalcoholic Bark Extract: Chemical Characterisation and Cytotoxic, Mutagenic, and Preclinical Aspects Associated with a Protective Effect on Oxidative Stress
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Tiago Felipe de Senes-Lopes, Jefferson Romáryo Duarte da Luz, Zaira da Rosa Guterres, Eder A. Barbosa, Débora Batista, Ony Araújo Galdino, Marcela Abbott Galvão Ururahy, Elizabeth Cristina Gomes dos Santos, Jorge A. López, Gabriel Araujo-Silva, and Maria das Graças Almeida
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caatinga biome ,Pseudobombax parvifolium ,oxidative stress ,traditional medicine ,Microbiology ,QR1-502 - Abstract
Plants have long been used in traditional medicine to treat illnesses. Nevertheless, their chemical diversity requires studies to establish the extract dosage and its safe use. Pseudobombax parvifolium, an endemic species of the Brazilian Caatinga biome, is commonly used in folk medicine, due to its anti-inflammatory properties related to cellular oxidative stress; however, its biological properties have scarcely been studied. In this study, we chemically characterized the P. parvifolium hydroalcoholic bark extract (EBHE) and evaluated its cytotoxic, mutagenic, and preclinical aspects, as well as its antioxidant effect. Our phytochemical analysis revealed a significative total polyphenol content and identified loliolide for the first time in this species. Cytotoxicity, mutagenicity, and acute oral and repeated dose indicated no toxic effects on cell culture, Drosophila melanogaster, and Wistar rat exposure to different EBHE concentrations, respectively. Furthermore, we observed a significant decrease in lipid peroxidation and a mild hypoglycemic and hypolipidemic effect with repeated oral dosing of EBHE. Although there were no significant changes in glutathione content, we did observe a significant increase in superoxide dismutase at a dose of 400 mg/kg and in glutathione peroxidase at doses of 100, 200, and 400 mg/kg. These findings suggest that EBHE has potential as a source of bioactive molecules, and it can be used safely in traditional medicine and in the development of herbal medicines for application in the public health system.
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- 2023
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49. Monitoring water quality changes and ornamental fish behaviour during commercial transport
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Vanderzwalmen, Myriam, McNeill, Jason, Delieuvin, Dorine, Senes, Simona, Sanchez-Lacalle, Daniel, Mullen, Carrie, McLellan, Iain, Carey, Peter, Snellgrove, Donna, Foggo, Andy, Alexander, Mhairi E., Henriquez, Fiona L., and Sloman, Katherine A.
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- 2021
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50. Determination of phenolic acids and flavonoids from Myrciaria cauliflora edible part employing vortex-assisted matrix solid-phase dispersion (VA-MSPD) and UHPLC-MS/MS
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Senes, Carlos Eduardo Rubio, Rodrigues, Carina Alexandra, Nicácio, Antonio Eduardo, Boeing, Joana Schuelter, Maldaner, Liane, and Visentainer, Jesuí Vergílio
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- 2021
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