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10. Deep learning-based phenotyping reclassifies combined hepatocellular-cholangiocarcinoma

Author

Calderaro, Julien, Ghaffari Laleh, Narmin, Zeng, Qinghe, Maille, Pascale, Favre, Loetitia, Pujals, Anaïs, Klein, Christophe, Bazille, Céline, Heij, Lara R., Uguen, Arnaud, Luedde, Tom, Di Tommaso, Luca, Beaufrère, Aurélie, Chatain, Augustin, Gastineau, Delphine, Nguyen, Cong Trung, Nguyen-Canh, Hiep, Thi, Khuyen Nguyen, Gnemmi, Viviane, Graham, Rondell P., Charlotte, Frédéric, Wendum, Dominique, Vij, Mukul, Allende, Daniela S., Aucejo, Federico, Diaz, Alba, Rivière, Benjamin, Herrero, Astrid, Evert, Katja, Calvisi, Diego Francesco, Augustin, Jérémy, Leow, Wei Qiang, Leung, Howard Ho Wai, Boleslawski, Emmanuel, Rela, Mohamed, François, Arnaud, Cha, Anthony Wing-Hung, Forner, Alejandro, Reig, Maria, Allaire, Manon, Scatton, Olivier, Chatelain, Denis, Boulagnon-Rombi, Camille, Sturm, Nathalie, Menahem, Benjamin, Frouin, Eric, Tougeron, David, Tournigand, Christophe, Kempf, Emmanuelle, Kim, Haeryoung, Ningarhari, Massih, Michalak-Provost, Sophie, Gopal, Purva, Brustia, Raffaele, Vibert, Eric, Schulze, Kornelius, Rüther, Darius F., Weidemann, Sören A., Rhaiem, Rami, Pawlotsky, Jean-Michel, Zhang, Xuchen, Luciani, Alain, Mulé, Sébastien, Laurent, Alexis, Amaddeo, Giuliana, Regnault, Hélène, De Martin, Eleonora, Sempoux, Christine, Navale, Pooja, Westerhoff, Maria, Lo, Regina Cheuk-Lam, Bednarsch, Jan, Gouw, Annette, Guettier, Catherine, Lequoy, Marie, Harada, Kenichi, Sripongpun, Pimsiri, Wetwittayaklang, Poowadon, Loménie, Nicolas, Tantipisit, Jarukit, Kaewdech, Apichat, Shen, Jeanne, Paradis, Valérie, Caruso, Stefano, and Kather, Jakob Nikolas

Published
2023
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12. Artificial intelligence-based pathology as a biomarker of sensitivity to atezolizumab–bevacizumab in patients with hepatocellular carcinoma: a multicentre retrospective study

Author

Allende, Daniela S, Amaddeo, Giuliana, Argemi, Josepmaria, Baulande, Sylvain, Beaufrère, Aurélie, Bermúdez-Ramos, María, Boulagnon-Rombi, Camille, Boursier, Jérôme, Bruges, Léa, Calderaro, Julien, Campani, Claudia, Caruso, Stefano, Casadei-Gardini, Andrea, Castano Garcia, Andres, Chan, Stephen Lam, D'Alessio, Antonio, Di Tommaso, Luca, Diaz, Alba, Digklia, Antonia, Dufour, Jean-François, Garcia-Porrero, Guillermo, Ghaffari Laleh, Narmin, Gnemmi, Viviane, Gopal, Purva, Graham, Rondell P., Heurgué, Alexandra, Iavarone, Massimo, Iñarrairaegui, Mercedes, Kather, Jakob Nikolas, Klein, Christophe, Labgaa, Ismail, Lameiras, Sonia, Legoix, Patricia, Lequoy, Marie, Leung, Howard Ho-Wai, Loménie, Nicolas, Maggioni, Marco, Maille, Pascale, Marín-Zuluaga, Juan Ignacio, Mendoza-Pacas, Guillermo, Michalak, Sophie, Mínguez, Beatriz, El Nahhas, Omar S M, Nault, Jean-Charles, Navale, Pooja, Ningarhari, Massih, Paradis, Valérie, Park, Young Nyun, Pawlotsky, Jean-Michel, Pedica, Federica, Perbellini, Riccardo, Peter, Simon, Pinato, David James, Pinter, Matthias, Radu, Pompilia, Regnault, Hélène, Reig, Maria, Rela, Mohamed, Rhee, Hyungjin, Rimassa, Lorenza, Rimini, Margherita, Salcedo, María Teresa, Sangro, Bruno, Scheiner, Bernhard, Sempoux, Christine, Su, Tung-Hung, Torres, Callie, Tran, Nguyen H, Trépo, Eric, Varela, Maria, Verset, Gontran, Vij, Mukul, Vogel, Arndt, Wendum, Dominique, Zeng, Qinghe, and Ziol, Marianne

Published
2023
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13. Towards a national strategy for digital pathology in Switzerland

Author

Janowczyk, Andrew, Baumhoer, Daniel, Dirnhofer, Stefan, Grobholz, Rainer, Kipar, Anja, de Leval, Laurence, Merkler, Doron, Michielin, Olivier, Moch, Holger, Perren, Aurel, Rottenberg, Sven, Rubbia-Brandt, Laura, Rubin, Mark A., Sempoux, Christine, Tolnay, Markus, Zlobec, Inti, and Koelzer, Viktor Hendrik

Published
2022
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14. Nestin as a diagnostic and prognostic marker for combined hepatocellular-cholangiocarcinoma

Author

Calderaro, Julien, Di Tommaso, Luca, Maillé, Pascale, Beaufrère, Aurélie, Nguyen, Cong Trung, Heij, Lara, Gnemmi, Viviane, Graham, Rondell P., Charlotte, Frédéric, Chartier, Suzanne, Wendum, Dominique, Vij, Mukul, Allende, Daniela, Diaz, Alba, Fuster, Carla, Rivière, Benjamin, Herrero, Astrid, Augustin, Jérémy, Evert, Katja, Calvisi, Diego Francesco, Leow, Wei Qiang, Leung, Howard Ho Wai, Bednarsch, Jan, Boleslawski, Emmanuel, Rela, Mohamed, Chan, Anthony Wing-Hung, Forner, Alejandro, Reig, Maria, Pujals, Anaïs, Favre, Loetitia, Allaire, Manon, Scatton, Olivier, Uguen, Arnaud, Trépo, Eric, Sanchez, Lukas Otero, Chatelain, Denis, Remmelink, Myriam, Boulagnon-Rombi, Camille, Bazille, Céline, Sturm, Nathalie, Menahem, Benjamin, Frouin, Eric, Tougeron, David, Tournigand, Christophe, Kempf, Emmanuelle, Kim, Haeryoung, Ningarhari, Massih, Michalak-Provost, Sophie, Kather, Jakob Nikolas, Gouw, Annette S.H., Gopal, Purva, Brustia, Raffaele, Vibert, Eric, Schulze, Kornelius, Rüther, Darius F., Weidemann, Sören A., Rhaiem, Rami, Nault, Jean-Charles, Laurent, Alexis, Amaddeo, Giuliana, Regnault, Hélène, de Martin, Eleonora, Sempoux, Christine, Navale, Pooja, Shinde, Jayendra, Bacchuwar, Ketan, Westerhoff, Maria, Lo, Regina Cheuk-Lam, Sebbagh, Mylène, Guettier, Catherine, Lequoy, Marie, Komuta, Mina, Ziol, Marianne, Paradis, Valérie, Shen, Jeanne, and Caruso, Stefano

Published
2022
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17. Ampullary Neuroendocrine Neoplasms: Identification of Prognostic Factors in a Multicentric Series of 119 Cases

Author

Vanoli, Alessandro, Grami, Oneda, Klersy, Catherine, Milanetto, Anna Caterina, Albarello, Luca, Fassan, Matteo, Luchini, Claudio, Grillo, Federica, Spaggiari, Paola, Inzani, Frediano, Uccella, Silvia, Parente, Paola, Nappo, Gennaro, Mattiolo, Paola, Milione, Massimo, Pietrabissa, Andrea, Cobianchi, Lorenzo, Schiavo Lena, Marco, Partelli, Stefano, Di Sabatino, Antonio, Sempoux, Christine, Capella, Carlo, Pasquali, Claudio, Doglioni, Claudio, Sessa, Fausto, Scarpa, Aldo, Rindi, Guido, Paulli, Marco, Zerbi, Alessandro, Falconi, Massimo, Solcia, Enrico, and La Rosa, Stefano

Published
2022
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18. Apelin-driven endothelial cell migration sustains intestinal progenitor cells and tumor growth

Author

Bernier-Latmani, Jeremiah, Cisarovsky, Christophe, Mahfoud, Samantha, Ragusa, Simone, Dupanloup, Isabelle, Barras, David, Renevey, François, Nassiri, Sina, Anderle, Pascale, Squadrito, Mario Leonardo, Siegert, Stefanie, Davanture, Suzel, González-Loyola, Alejandra, Fournier, Nadine, Luther, Sanjiv A., Benedito, Rui, Valet, Philippe, Zhou, Bin, De Palma, Michele, Delorenzi, Mauro, Sempoux, Christine, and Petrova, Tatiana V.

Published
2022
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21. cHCC‐CCA: Consensus terminology for primary liver carcinomas with both hepatocytic and cholangiocytic differentation

Author

Brunt, Elizabeth, Aishima, Shinichi, Clavien, Pierre‐Alain, Fowler, Kathryn, Goodman, Zachary, Gores, Gregory, Gouw, Annette, Kagen, Alex, Klimstra, David, Komuta, Mina, Kondo, Fukuo, Miksad, Rebecca, Nakano, Masayuki, Nakanuma, Yasuni, Ng, Irene, Paradis, Valerie, Park, Young Nyun, Quaglia, Alberto, Roncalli, Massimo, Roskams, Tania, Sakamoto, Michiie, Saxena, Romil, Sempoux, Christine, Sirlin, Claude, Stueck, Ashley, Thung, Swan, Tsui, WMS, Wang, Xin‐Wei, Wee, Aileen, Yano, Hirohisa, Yeh, Matthew, Zen, Yoh, Zucman‐Rossi, Jessica, and Theise, Neil

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Liver Cancer, Rare Diseases, Cancer, Liver Disease, Digestive Diseases, Aged, Carcinoma, Hepatocellular, Cholangiocarcinoma, Female, Humans, Liver, Liver Neoplasms, Radiography, Terminology as Topic, Medical Biochemistry and Metabolomics, Immunology, Gastroenterology & Hepatology, Clinical sciences
Abstract

Primary liver carcinomas with both hepatocytic and cholangiocytic differentiation have been referred to as "combined (or mixed) hepatocellular-cholangiocarcinoma." These tumors, although described over 100 years ago, have attracted greater attention recently because of interest in possible stem cell origin and perhaps because of greater frequency and clinical recognition. Currently, because of a lack of common terminology in the literature, effective treatment and predictable outcome data have been challenging to accrue. This article represents a consensus document from an international community of pathologists, radiologists, and clinicians who have studied and reported on these tumors and recommends a working terminology for diagnostic and research approaches for further study and evaluation.ConclusionIt is recommended that diagnosis is based on routine histopathology with hematoxylin and eosin (H&E); immunostains are supportive, but not essential for diagnosis. (Hepatology 2018;68:113-126).

Published
2018

23. Treatment Response After Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) for Peritoneal Metastases of Colorectal Originf

Author

Martin Hübner, MD, S. P. Somashekhar, MD, Hugo Teixeira Farinha, MD, Julio Abba, MD, Ramya G. Rao, PhD, Mohammad Alyami, MD, Wouter Willaert, MD, PhD, on behalf of the PIPAC study group, Brigand Cecile, MD, Delhorme Jean-Baptiste, MD, PhD, Romain Benoit, MD, PhD, Charleux-Muller Diane, MD, Bertin Jean-Baptiste, MD, Rohr Serge, MD, Jager Tarkan, MD, Neureiter Daniel, MD, Schredl Philipp, MD, Weiss Lukas, MD, Klieser Eckhard, MD, Emmanuel Klaus, MD, Sgarbura Olivia, MD, PhD, Bouillin Alix, MD, Khellaf Lakhdar, MD, Nougaret Stephanie, MD, PhD, Samalin Emmanuelle, MD, Mazard Thibault, MD, PhD, Glehen Olivier, MD, PhD, Kepenekian Vahan, MD, PhD, Villeneuve Laurent, PhD, Hubner Martin, Demartines Nicolas, MD, Teixeira-Farinha Hugo, MD, Clerc Daniel, MD, Dromain Clarisse, MD, Sempoux Christine, MD, PhD, Robella Manuela, MD, Vaira Marco, MD, De Simone Michele, MD, Di Giorgio Andrea, MD, Ferracci Federica, MD, Rotolo Stefano, MD, Schena Carlo Alberto, MD, Inzani Frediano, MD, Bagala Cinzia, MD, Babucke Maximilian, MD, Piso Pompiliu, PhD, MD, Somashekhar s p, MD, Ashwin KR, DNB, Rohit Kumar, DNB, Susmita Rakshit, MBBS, MD, Amit Rauthan, DM, Bhatt Aditi, MS, MCh., Shaikh Sakina, BH,MS, MBA, Parikh Loma, MD, Sheth Sandeep, MD, Panchal Amee, MD, Thakkar Shweta, MD, Ezzano Anne-Cecile, MD, Aime Adeline, MD, Eveno Clarisse, MD, PhD, Noiret Barbara, MD, Khomiakov Vladimir, PhD, Ryabov Andrey, PhD, Utkina Anna, PhD, Aksenov Sergey, MD, Bolotina Larisa, PhD, Kaprin Andrey, PhD, Willaert Wouter, MD, PhD, Cosyns Sarah, PhD, MSc, Akhayad Soumaya, BSN, Ceelen Wim, MD, PhD, Gockel Ines, MD, Jansen-Winkeln Boris, MD, Thieme Rene, PhD, Schierle Katrin, MD, Moulla Yusef, MD, Mehdorn Matthias, MD, Abba Julio, MD, Trilling Bertrand, MD, PhD, Tidadini Fatah, MSc, Bonne Aline, MD, Arvieux Catherine, MD, PhD, Orry David, MD, Basso Valeria, MD, Ghiringhelli Francois, MD, PhD, Escayola Cecilia, MD, Torrent Juan Jose, MD, Alyami Mohammad, MD, Alqannas Mashhour, MD, Cortes Guiral Delia, MD, PhD, Alammari samer, MD, Bashanfer Galal, MD, Alshukami Anwar, MD, Reymond Marc A., MD, Solass Wiebke, MD, and Nadiradze Giorgi, MD

Subjects
Surgery, RD1-811
Abstract

Objective:. The objective of this study is to analyze oncological outcomes of patients with peritoneal metastases (PM) of colorectal origin treated with Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC). Background:. PIPAC has been demonstrated to be a feasible and safe novel treatment for patients with PM of various origins. Only small series reports on survival after PIPAC by disease entity. Methods:. International retrospective cohort study of consecutive patients with PM of colorectal origin. Outcome measures were overall survival (OS), radiological response according to Response Evaluation Criteria in Solid Tumors (RECIST), histological response (peritoneal regression grading score [PRGS]: complete response: 1–4: no response), change of peritoneal cancer index (PCI), and symptom control. Results:. Seventeen eligible centers compiled 256 non-selected patients (mean age 61 [50.6–69.2], 43% female) and 606 procedures. Sixty-three percent were treated after 2 lines of chemotherapy, median PCI at PIPAC1 was 18 (interquartile range [IQR] = 10–27). Median OS was 19.00 months (IQR = 12.9–29.8) from diagnosis and 9.4 months (IQR = 4.5–16.8) from PIPAC1. One hundred and four of 256 patients (40.6%) had ≥3 procedures (per protocol [pp]) with the following outcomes at PIPAC3: RECIST: 59.3% partial response/stable, 40.7% progression; mean PRGS: 2.1 ± 0.9. Median PCI was 21 (IQR = 15–29) at baseline and 20 (IQR = 12–27) at PIPAC3 (P = 0.02). Fifty-six (54%) and 48 (46%) patients were symptomatic at baseline and PIPAC3, respectively (P = 0.267). Median OS for the pp cohort was 11.9 months (IQR = 10.7–15.0) from PIPAC1. Independent predictors for survival were radiological response (HR = 3.0; 95% CI = 1.6–5.7) and no symptoms (HR = 4.5, 95% CI = 2.2–9.1) at PIPAC3. Conclusions:. Objective treatment response and encouraging survival were demonstrated after PIPAC for colorectal PM. Prospective registry data and comparative studies are now needed in to confirm these data.

Published
2022
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24. Histological regression of gastrointestinal peritoneal metastases after systemic chemotherapy

Author

Toussaint Laura, Teixeira Farinha Hugo, Barras Jean-Luc, Demartines Nicolas, Sempoux Christine, and Hübner Martin

Subjects
chemotherapy, peritoneal metastasis, peritoneal regression grading system (prgs), pipac, Medicine, Specialties of internal medicine, RC581-951
Abstract

Peritoneal metastases (PM) are relatively resistant to systemic chemotherapy, and data on histological response to therapy is rare. The aim of this study was to quantify the treatment response of PM after systemic chemotherapy.

Published
2021
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30. Immune-Related Adverse Events Induced by Immune Checkpoint Inhibitors and CAR-T Cell Therapy: A Comprehensive Imaging-Based Review.

Author

Pozzessere, Chiara, Mazini, Bianca, Omoumi, Patrick, Jreige, Mario, Noirez, Leslie, Digklia, Antonia, Fasquelle, François, Sempoux, Christine, and Dromain, Clarisse

Subjects
TUMOR treatment, VASCULITIS, PNEUMONIA, PERICARDIAL effusion, DRUG side effects, CARDIOMYOPATHIES, HEPATITIS, PITUITARY gland, IMMUNOTHERAPY, MENINGITIS, CHOLANGITIS, CYTOKINE release syndrome, COMPUTED tomography, CELLULAR therapy, PERICARDITIS, ENTEROCOLITIS, MAGNETIC resonance imaging, POSITRON emission tomography computed tomography, IMMUNE checkpoint inhibitors, NEUROLOGICAL disorders, PANCREATITIS, ENCEPHALITIS, CENTRAL nervous system diseases, DEMYELINATION, BRONCHOSCOPY, INFLAMMATION, THYROIDITIS
Abstract

Simple Summary: Immunotherapy has been introduced as a standard of care for several cancers, and its use is on the rise. However, the enhanced immune system frequently causes immune-related adverse events. Depending on the affected organ and tissue and the severity of the toxicity, immunotherapy is generally held, and steroids or immunosuppressive agents are introduced, impacting cancer treatment. Therefore, prompt identification of toxicity at an early stage and multidisciplinary management are mandatory. Since imaging is crucial to guide clinicians in managing immune-related adverse events, this imaging-based review presents the most frequent complications identifiable on imaging. Clues for identification and the most important differential diagnoses are discussed to enhance knowledge among imaging specialists and clinicians regarding these complications. Immunotherapy has revolutionized oncology care, improving patient outcomes in several cancers. However, these therapies are also associated with typical immune-related adverse events due to the enhanced inflammatory and immune response. These toxicities can arise at any time during treatment but are more frequent within the first few months. Any organ and tissue can be affected, ranging from mild to life-threatening. While some manifestations are common and more often mild, such as dermatitis and colitis, others are rarer and more severe, such as myocarditis. Management depends on the severity, with treatment being held for >grade 2 toxicities. Steroids are used in more severe cases, and immunosuppressive treatment may be considered for non-responsive toxicities, along with specific organ support. A multidisciplinary approach is mandatory for prompt identification and management. The diagnosis is primarily of exclusion. It often relies on imaging features, and, when possible, cytologic and/or pathological analyses are performed for confirmation. In case of clinical suspicion, imaging is required to assess the presence, extent, and features of abnormalities and to evoke and rule out differential diagnoses. This imaging-based review illustrates the diverse system-specific toxicities associated with immune checkpoint inhibitors and chimeric antigen receptor T-cells with a multidisciplinary perspective. Clinical characteristics, imaging features, cytological and histological patterns, as well as the management approach, are presented with insights into radiological tips to distinguish these toxicities from the most important differential diagnoses and mimickers—including tumor progression, pseudoprogression, inflammation, and infection—to guide imaging and clinical specialists in the pathway of diagnosing immune-related adverse events. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Spatial transcriptomics profiling of gallbladder adenocarcinoma: a detailed two-case study of progression from precursor lesions to cancer

Author

Pirenne, Sophie, primary, Manzano-Nunez, Fatima, additional, Loriot, Axelle, additional, Cordi, Sabine, additional, Desmet, Lieven, additional, Aydin, Selda, additional, Hubert, Catherine, additional, Toffoli, Sebastien, additional, Limaye, Nisha, additional, Sempoux, Christine, additional, Komuta, Mina, additional, Gatto, Laurent, additional, and Lemaigre, Frederic P, additional

Published
2024
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36. Response to tumor-infiltrating lymphocyte adoptive therapy is associated with preexisting CD8 + T-myeloid cell networks in melanoma

Author

Barras, David, primary, Ghisoni, Eleonora, additional, Chiffelle, Johanna, additional, Orcurto, Angela, additional, Dagher, Julien, additional, Fahr, Noémie, additional, Benedetti, Fabrizio, additional, Crespo, Isaac, additional, Grimm, Alizée J., additional, Morotti, Matteo, additional, Zimmermann, Stefan, additional, Duran, Rafael, additional, Imbimbo, Martina, additional, de Olza, Maria Ochoa, additional, Navarro, Blanca, additional, Homicsko, Krisztian, additional, Bobisse, Sara, additional, Labes, Danny, additional, Tsourti, Zoe, additional, Andriakopoulou, Charitini, additional, Herrera, Fernanda, additional, Pétremand, Rémy, additional, Dummer, Reinhard, additional, Berthod, Gregoire, additional, Kraemer, Anne I., additional, Huber, Florian, additional, Thevenet, Jonathan, additional, Bassani-Sternberg, Michal, additional, Schaefer, Niklaus, additional, Prior, John O., additional, Matter, Maurice, additional, Aedo, Veronica, additional, Dromain, Clarisse, additional, Corria-Osorio, Jesus, additional, Tissot, Stéphanie, additional, Kandalaft, Lana E., additional, Gottardo, Raphael, additional, Pittet, Mikaël, additional, Sempoux, Christine, additional, Michielin, Olivier, additional, Dafni, Urania, additional, Trueb, Lionel, additional, Harari, Alexandre, additional, Laniti, Denarda Dangaj, additional, and Coukos, George, additional

Published
2024
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38. Hepatic small vessel neoplasm, a rare infiltrative vascular neoplasm of uncertain malignant potential

Author

Gill, Ryan M, Buelow, Benjamin, Mather, Cheryl, Joseph, Nancy M, Alves, Venancio, Brunt, Elizabeth M, Liu, Ta-Chiang, Makhlouf, Hala, Marginean, Celia, Nalbantoglu, ILKe, Sempoux, Christine, Snover, Dale C, Thung, Swan N, Yeh, Matthew M, and Ferrell, Linda D

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Rare Diseases, Digestive Diseases, Cancer, 2.1 Biological and endogenous factors, Aetiology, Adult, Aged, Aged, 80 and over, Biomarkers, Tumor, Cell Proliferation, Class I Phosphatidylinositol 3-Kinases, DNA Mutational Analysis, Diagnosis, Differential, Female, GTP-Binding Protein alpha Subunits, Gq-G11, Hemangioma, Cavernous, Hemangiosarcoma, Humans, Immunohistochemistry, Ki-67 Antigen, Liver Neoplasms, Male, Middle Aged, Mutation, Neoplasm Grading, Phosphatidylinositol 3-Kinases, Predictive Value of Tests, Proto-Oncogene Proteins c-myc, Terminology as Topic, Tumor Suppressor Protein p53, Vascular Neoplasms, Young Adult, Liver, Hemangioma, Angiosarcoma, Hepatic small vessel neoplasm, GNAQ, Clinical Sciences, Pathology, Clinical sciences
Abstract

Characteristic but rare vascular neoplasms in the adult liver composed of small vessels with an infiltrative border were collected from an international group of collaborators over a 5-year period (N=17). These tumors were termed hepatic small vessel neoplasm (HSVN), and the histologic differential diagnosis was angiosarcoma (AS). The average age of patients was 54years (range, 24-83years). HSVN was more common in men. The average size was 2.1cm (range, 0.2-5.5cm). Diagnosis was aided by immunohistochemical stains for vascular lineage (CD31, CD34, FLI-1), which were uniformly positive in HSVN. Immunohistochemical stains (p53, c-Myc, GLUT-1, and Ki-67) for possible malignant potential are suggestive of a benign/low-grade tumor. Capture-based next-generation sequencing (using an assay that targets the coding regions of more than 500 cancer genes) identified an activating hotspot GNAQ mutation in 2 of 3 (67%) tested samples, and one of these cases also had a hotspot mutation in PIK3CA. When compared with hepatic AS (n=10) and cavernous hemangioma (n=6), the Ki-67 proliferative index is the most helpful tool in excluding AS, which demonstrated a tumor cell proliferative index greater than 10% in all cases. Strong p53 and diffuse c-Myc staining was also significantly associated with AS but not with HSVN or cavernous hemangioma. There have been no cases with rupture/hemorrhage, disseminated intravascular coagulation, or Kasabach-Merritt syndrome. Thus far, there has been no metastasis or recurrence of HSVN, but complete resection and close clinical follow-up are recommended because the outcome remains unknown.

Published
2016

41. Macroscopic Characterization of Hepatocellular Carcinoma: An Underexploited Source of Prognostic Factors.

Author

Gonvers, Stéphanie, Martins-Filho, Sebastiao N., Hirayama, André, Calderaro, Julien, Phillips, Rebecca, Uldry, Emilie, Demartines, Nicolas, Melloul, Emmanuel, Young Nyun Park, Paradis, Valérie, Thung, Swan N., Alves, Venancio, Sempoux, Christine, and Labgaa, Ismail

Subjects
PROGNOSIS, BILE ducts, SURGICAL margin, LIVER transplantation, INTERDISCIPLINARY research, HEPATOCELLULAR carcinoma
Abstract

The macroscopic appearance of a tumor such as hepatocellular carcinoma (HCC) may be defined as its phenotype which is de facto dictated by its genotype. Therefore, macroscopic characteristics of HCC are unlikely random but rather reflect genomic traits of cancer, presumably acting as a valuable source of information that can be retrieved and exploited to infer prognosis. This review aims to provide a comprehensive overview of the available data on the prognostic value of macroscopic characterization in HCC. A total of 57 studies meeting eligible criteria were identified, including patients undergoing liver resection (LR; 47 studies, 83%) or liver transplant (LT; 9 studies, 16%). The following macroscopic variables were investigated: tumor size (n = 42 studies), number of nodules (n = 28), vascular invasion (n = 24), bile duct invasion (n = 6), growth pattern (n = 15), resection margin (n = 11), tumor location (n = 6), capsule (n = 2) and satellite (n = 1). Although the selected studies provided insightful data with notable prognostic performances, a lack of standardization and substantial gaps were noted in the report and the analysis of gross findings. This topic remains incompletely covered. While the available studies underscored the value of macroscopic variables in HCC prognostication, important lacks were also observed. Macroscopic characterization of HCC is likely an underexploited source of prognostic factors that must be actively explored by future multidisciplinary research. [ABSTRACT FROM AUTHOR]

Published
2024
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42. Artificial intelligence-based pathology as a biomarker of sensitivity to atezolizumab–bevacizumab in patients with hepatocellular carcinoma: a multicentre retrospective study

Author

Zeng, Qinghe, primary, Klein, Christophe, additional, Caruso, Stefano, additional, Maille, Pascale, additional, Allende, Daniela S, additional, Mínguez, Beatriz, additional, Iavarone, Massimo, additional, Ningarhari, Massih, additional, Casadei-Gardini, Andrea, additional, Pedica, Federica, additional, Rimini, Margherita, additional, Perbellini, Riccardo, additional, Boulagnon-Rombi, Camille, additional, Heurgué, Alexandra, additional, Maggioni, Marco, additional, Rela, Mohamed, additional, Vij, Mukul, additional, Baulande, Sylvain, additional, Legoix, Patricia, additional, Lameiras, Sonia, additional, Amaddeo, Giuliana, additional, Argemi, Josepmaria, additional, Beaufrère, Aurélie, additional, Bermúdez-Ramos, María, additional, Boursier, Jérôme, additional, Bruges, Léa, additional, Calderaro, Julien, additional, Campani, Claudia, additional, Castano Garcia, Andres, additional, Chan, Stephen Lam, additional, D'Alessio, Antonio, additional, Di Tommaso, Luca, additional, Diaz, Alba, additional, Digklia, Antonia, additional, Dufour, Jean-François, additional, Garcia-Porrero, Guillermo, additional, Ghaffari Laleh, Narmin, additional, Gnemmi, Viviane, additional, Gopal, Purva, additional, Graham, Rondell P., additional, Iñarrairaegui, Mercedes, additional, Kather, Jakob Nikolas, additional, Labgaa, Ismail, additional, Lequoy, Marie, additional, Leung, Howard Ho-Wai, additional, Loménie, Nicolas, additional, Marín-Zuluaga, Juan Ignacio, additional, Mendoza-Pacas, Guillermo, additional, Michalak, Sophie, additional, El Nahhas, Omar S M, additional, Nault, Jean-Charles, additional, Navale, Pooja, additional, Paradis, Valérie, additional, Park, Young Nyun, additional, Pawlotsky, Jean-Michel, additional, Peter, Simon, additional, Pinato, David James, additional, Pinter, Matthias, additional, Radu, Pompilia, additional, Regnault, Hélène, additional, Reig, Maria, additional, Rhee, Hyungjin, additional, Rimassa, Lorenza, additional, Salcedo, María Teresa, additional, Sangro, Bruno, additional, Scheiner, Bernhard, additional, Sempoux, Christine, additional, Su, Tung-Hung, additional, Torres, Callie, additional, Tran, Nguyen H, additional, Trépo, Eric, additional, Varela, Maria, additional, Verset, Gontran, additional, Vogel, Arndt, additional, Wendum, Dominique, additional, Zeng, Qinghe, additional, and Ziol, Marianne, additional

Published
2023
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43. Prospective evaluation of MR-TRG (Tumor Regression Grade) in esophageal cancer after neo-adjuvant therapy: Preliminary results

Author

Chapellier, Pauline, primary, Fasquelle, François, additional, Saglietti, Chiara, additional, Kinj, Rémy, additional, Mantziari, Styliani, additional, Schäfer, Markus, additional, Haefliger, Laura, additional, Jreige, Mario, additional, Vietti Violi, Naïk, additional, Sempoux, Christine, additional, and Dromain, Clarisse, additional

Published
2023
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44. Sonic hedgehog hepatocellular adenoma: magnetic resonance imaging features and correlation with histology

Author

Ducatel, Arnaud, primary, Trillaud, Hervé, additional, Reizine, Edouard, additional, Vilgrain, Valérie, additional, Sempoux, Christine, additional, Schmidt-Kobbe, Sabine, additional, Gouw, Annette S. H., additional, de Haas, Robbert J, additional, Julien, Céline, additional, Paradis, Valérie, additional, Blanc, Jean-Frédéric, additional, Chiche, Laurence, additional, Balabaud, Charles, additional, Bioulac-Sage, Paulette, additional, and Frulio, Nora, additional

Published
2023
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46. Primary hepatocellular carcinoma of the spleen

Author

Saglietti, Chiara, primary, Fasquelle, François, additional, Barcena, Carmen, additional, Schmidt, Sabine, additional, Shirata, Chikara, additional, Uldry, Emilie, additional, Halkic, Nermin, additional, and Sempoux, Christine, additional

Published
2023
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48. Combination of Gene Expression Signature and Model for End-Stage Liver Disease Score Predicts Survival of Patients With Severe Alcoholic Hepatitis

Author

Trépo, Eric, Goossens, Nicolas, Fujiwara, Naoto, Song, Won-Min, Colaprico, Antonio, Marot, Astrid, Spahr, Laurent, Demetter, Pieter, Sempoux, Christine, Im, Gene Y., Saldarriaga, Joan, Gustot, Thierry, Devière, Jacques, Thung, Swan N., Minsart, Charlotte, Sersté, Thomas, Bontempi, Gianluca, Abdelrahman, Karim, Henrion, Jean, Degré, Delphine, Lucidi, Valerio, Rubbia-Brandt, Laura, Nair, Venugopalan D., Moreno, Christophe, Deltenre, Pierre, Hoshida, Yujin, and Franchimont, Denis

Published
2018
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