Search

Your search keyword '"Semple, Scott Ik"' showing total 12 results
Start Over Author "Semple, Scott Ik"
12 results on '"Semple, Scott Ik"'

6. Ferumoxytol-enhanced magnetic resonance imaging in acute myocarditis

Author

Stirrat, Colin G, primary, Alam, Shirjel R, additional, MacGillivray, Thomas J, additional, Gray, Calum D, additional, Dweck, Marc R, additional, Dibb, Kevin, additional, Spath, Nick, additional, Payne, John R, additional, Prasad, Sanjay K, additional, Gardner, Roy S, additional, Mirsadraee, Saeed, additional, Henriksen, Peter A, additional, Semple, Scott IK, additional, and Newby, David E, additional

Published
2017
Full Text
View/download PDF

8. Ferumoxytol-enhanced magnetic resonance imaging in acute myocarditis.

Author

Stirrat, Colin G., Alam, Shirjel R., MacGillivray, Thomas J., Gray, Calum D., Dweck, Marc R., Dibb, Kevin, Spath, Nick, Payne, John R., Prasad, Sanjay K., Gardner, Roy S., Mirsadraee, Saeed, Henriksen, Peter A., Semple, Scott I. K., Newby, David E., and Semple, Scott Ik

Subjects
MYOCARDITIS, MAGNETIC resonance imaging, SUPERPARAMAGNETIC materials, IRON oxides, MACROPHAGES, DEXTRAN, DIAGNOSTIC imaging, IMMUNITY, INFLAMMATION, IRON compounds, COMPUTERS in medicine, MYOCARDIUM, CARDIOMYOPATHIES, RESEARCH funding, PREDICTIVE tests, CONTRAST media, ACUTE diseases
Abstract

Objectives: Ultrasmall superparamagnetic particles of iron oxide (USPIO)-enhanced MRI can detect tissue-resident macrophage activity and identify cellular inflammation within tissues. We hypothesised that USPIO-enhanced MRI would provide a non-invasive imaging technique that would improve the diagnosis and management of patients with acute myocarditis.Methods: Ten volunteers and 14 patients with suspected acute myocarditis underwent T2, T2* and late gadolinium enhancement (LGE) 3T MRI, with further T2* imaging at 24 hours after USPIO (ferumoxytol, 4 mg/kg) infusion, at baseline and 3 months. Myocardial oedema and USPIO enhancement were determined within areas of LGE as well as throughout the myocardium.Results: Myocarditis was confirmed in nine of the 14 suspected cases of myocarditis. There was greater myocardial oedema in regions of LGE in patients with myocarditis when compared with healthy volunteer myocardium (T2 value, 57.1±5.3 vs 46.7±1.6 ms, p<0.0001). There was no demonstrable difference in USPIO enhancement between patients and volunteers even within regions displaying LGE (change in R2*, 35.0±15.0 vs 37.2±9.6 s-1, p>0.05). Imaging after 3 months in patients with myocarditis revealed a reduction in volume of LGE, a reduction in oedema measures within regions displaying LGE and improvement in ejection fraction (mean -19.7 mL, 95% CI (-0.5 to -40.0)), -5.8 ms (-0.9 to -10.7) and +6% (0.5% to 11.5%), respectively, p<0.05 for all).Conclusion: In patients with acute myocarditis, USPIO-enhanced MRI does not provide additional clinically relevant information to LGE and T2 mapping MRI. This suggests that tissue-resident macrophages do not provide a substantial contribution to the myocardial inflammation in this condition.Clinical trial registration NCT02319278; Results. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

9. Measurement of myocardial blood flow by cardiovascular magnetic resonance perfusion: comparison of distributed parameter and Fermi models with single and dual bolus

Author

Papanastasiou, Giorgos, primary, Williams, Michelle C, additional, Kershaw, Lucy E, additional, Dweck, Marc R, additional, Alam, Shirjel, additional, Mirsadraee, Saeed, additional, Connell, Martin, additional, Gray, Calum, additional, MacGillivray, Tom, additional, Newby, David E, additional, and Semple, Scott IK, additional

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results