34 results on '"Semiz H"'
Search Results
2. Inflammation-based prognostic scores in geriatric patients with rectal cancer
- Author
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Manoglu, B., primary, Sokmen, S., additional, Bisgin, T., additional, Semiz, H. S., additional, Görken, İ. B., additional, and Ellidokuz, H., additional
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- 2022
- Full Text
- View/download PDF
3. A Patient Diagnosed with POEMS Syndrome with Atypical Presentation
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Seyin Semiz H, Duran M, Ozsan N, Saydam G, and Sarıkaya O
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Pediatrics ,medicine.medical_specialty ,business.industry ,Medicine ,General Medicine ,Presentation (obstetrics) ,business ,medicine.disease ,POEMS syndrome - Published
- 2018
4. Coexistence of Sarcoidosis and Gouty Arthritis [Coexistencia de sarcoidosis y artritis gotosa]
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Semiz H. and Kobak S.
- Subjects
Sarcoidosis ,Gouty arthritis ,Coexistence - Abstract
PubMed: 28838825, 2-s2.0-85027992420, Sarcoidosis is an inflammatory disease with unknown cause characterized by non-caseating granuloma formations. It may present with bilateral hilar lymphadenopathy, skin lesions, the involvement of eye and symptoms on the locomotor system. Gouty arthritis is an autoinflammatory disease characterized by hyperuricemia, recurrent arthritis attacks and the deposition of monosodium urate crystals in the joints and the surrounding tissues. We reported the coexistence of sarcoidosis and gouty arthritis in this paper. © 2017 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología
- Published
- 2019
5. Coexistence of sarcoidosis and adult onset Still disease [Coexistencia de sarcoidosis y enfermedad de Still del adulto]
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Semiz H. and Kobak S.
- Subjects
Sarcoidosis ,Adult onset Still's disease ,Coexistence - Abstract
PubMed: 28532741, 2-s2.0-85019848259, Sarcoidosis is a chronic, inflammatory disease with unknown cause characterized by non-caseating granuloma formations. It can be presented with bilateral hilar lymphadenopathy, skin lesions, eye involvement and locomotor system findings. Adult onset Still disease (AOSD) is a chronic inflammatory disease which presents with fever, arthritis and typical skin rashes. The disease is rare and can be misdiagnosed due to the absence of typical clinical and laboratory findings. The association of sarcoidosis and AOSD has not been previously reported in the literature. Herein we reported the development of AOSD in a patient followed by the diagnosis of sarcoidosis. The patient did not respond to high-dose corticosteroids and methotrexate therapy, and the disease was under control with anti-IL-6 (Tocilizumab) drug. © 2017 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología
- Published
- 2019
6. Malignancy in Patients with Sarcoidosis [Malignidad en pacientes con sarcoidosis]
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Kobak S., Yildiz F., Semiz H., Orman M., and Ege Üniversitesi
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Sarcoidosis ,Incidence ,Malignancy - Abstract
EgeUn###, The relationship between sarcoidosis and malignancy is not clear yet. We retrospectively evaluated 131 sarcoidosis patients followed-up at the single Rheumatology center. The incidence of malignancies was investigated in this cohort. A total of 6 (4.6%) patients with malignancy were identified in our cohort of 131 patients with sarcoidosis. Hodgkin lymphoma (HL) was detected in three patients, followed by one patient with breast cancer, one patient with thyroid cancer and one patient with testicular cancer. All patients had chronic sarcoidosis with pulmonary involvement, and only 1 patient had acute sarcoidosis with Löfgren's syndrome. HL developed concomitantly with sarcoidosis in one patient while other two patients developed disease before and after sarcoidosis diagnosis. Two patients with solid tumors developed malignancy years before sarcoidosis diagnosis, while one patient developed thyroid cancer during sarcoidosis follow-up. All 6 sarcoidosis–malignancy patients survived after six year years follow up. We found low incidence of malignancy in patients with sarcoidosis in our small cohort. The sarcoidosis–malignancy relationship can only be a coincidence and/or can be explained by a common pathogenesis. New prospective studies involving large patients series are needed in this regard. © 2019 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología
- Published
- 2019
7. A patient diagnosed with Kounis syndrome due to the metoclopramide: A case report [Metoklopramide bağlı olarak gelişen kounis sendrom: Olgu sunumu]
- Author
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Semiz H. and Ege Üniversitesi
- Subjects
Metoclopramide ,Kounis syndrome ,Allergic reaction - Abstract
In this case report, we mentioned that; a 23 years old and 14 week pregnant woman with no history of anaphylactic or allergic reaction and chronical disease admitted to the emergency department for severe nausea, diagnosed with the vasospastic anginal form of the Kounis syndrome because of the chest pain starting after anaphylactic reaction. We followed the patient with normal physical examination and clinical findings at intervals of six months without treatment. Following the first outpatient clinic, the physical examination and the laboratory tests were normal. At this time, approximately eight months have passed since the patient’s first application and the follow-up to the outpatient clinic is ongoing. © 2018 Turkish Journal of Immunology. All rights reserved.
- Published
- 2018
8. Malignancy in patients with sarcoidosis: a retrospective cohort study from Turkey
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Kobak, S., Yildiz, F., Semiz, H., Orman, M., İstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Şenol Kobak / 0000-0001-8270-640X, Kobak, Şenol, Şenol Kobak / AAO-2482-2020, Şenol Kobak / 12782228700, and Ege Üniversitesi
- Abstract
Congress of the European-League-Against-Rheumatism (EULAR) -- JUN 13-16, 2018 -- Amsterdam, NETHERLANDS, WOS: 000444351005148, European League Against Rheumatism
- Published
- 2018
9. A Patient Diagnosed with POEMS Syndrome with Atypical Presentation: A Case Report
- Author
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Geana Rc, Iliescu va, Sorostinean D, Dragan A, and Semiz H
- Subjects
Pathology ,medicine.medical_specialty ,Thrombocytosis ,business.industry ,Castleman disease ,Polyradiculoneuropathy ,Plasma cell neoplasm ,medicine.disease ,Organomegaly ,Vascular endothelial growth factor ,chemistry.chemical_compound ,chemistry ,Medicine ,medicine.symptom ,business ,Papilledema ,POEMS syndrome - Abstract
POEMS syndrome is a paraneoplastic syndrome due to an underlying plasma cell neoplasm. The major criteria for the syndrome are polyradiculoneuropathy, clonal plasma cell disorder (PCD), sclerotic bone lesions, elevated vascular endothelial growth factor, and the presence of Castleman disease. Minor features include organomegaly, endocrinopathy, characteristic skin changes, papilledema, extravascular volume overload, and thrombocytosis.
- Published
- 2018
10. Küratif rezeksiyon uygulanan ampuller adenokarsinomlu hastalarda pozitif lenf nodu oranı logaritmasının (LODDS) prognostik önemi
- Author
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Ellidokuz, Hülya, Aktürk, N, Semiz, H S, Astarcıoğlu, İ K, Ünek, İlkay Tuğba, Ağalar, Cihan, Egeli, Tufan, Aysal Ağalar, Anıl, Sağol, ÖZGÜL, Ünek, Tarkan, and Özbilgin, M
- Published
- 2017
11. Coexistence of sarcoidosis and Hashimoto thyroiditis
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Semiz, H., primary, Yalcin, M., additional, and Kobak, S., additional
- Published
- 2018
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12. AB1158 Malignancy in patients with sarcoidosis: a retrospective cohort study from turkey
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Kobak, S., primary, Yildiz, F., additional, Semiz, H., additional, and Orman, M., additional
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- 2018
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13. AB0993 Elderly - onset sarcoidosis: a single center comparative study
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Kobak, S, primary, Sever, F, additional, Semiz, H, additional, and Orman, M, additional
- Published
- 2017
- Full Text
- View/download PDF
14. THU0573 Concomitant autoimmune diseases in patients with sarcoidosis
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Kobak, S, primary, Sever, F, additional, Semiz, H, additional, and Orman, M, additional
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- 2017
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15. Restoration Project For Behram Pasha Han In Sivas
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Semiz, H. Nisa, Ahunbay, Zeynep, Restorasyon, and Restoration
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Türkiye ,Turkey ,Han ,Belgeleme ve koruma ,Documentation and conservation - Abstract
Tez (Yüksek Lisans) -- İstanbul Teknik Üniversitesi, Fen Bilimleri Enstitüsü, 2007, Thesis (M.Sc.) -- İstanbul Technical University, Institute of Science and Technology, 2007, Bu çalışmada, Sivas ili merkez ilçesinde bulunan Behram Paşa Hanı’nın tarihi ve mimari özellikleri araştırılarak yapının rölöve, restitüsyon ve restorasyon projeleri hazırlanmıştır. 16. yüzyılın ikinci yarısında Rum Eyaleti beylerbeyi Behram Paşa’nın vakfettiği yapı, kervan yolcularının konaklaması amacıyla yapılmış bir kent içi hanıdır. İki katlı ve avlulu olan yapının zemin katının aynı zamanda ticari amaçlı kullanıldığı da düşünülmektedir. 19. yüzyıl sonunda kışlaya dönüştürülen han, Cumhuriyet döneminde de Milli Savunma Bakanlığı tarafından 1976 yılına kadar kullanılmıştır. Bu tarihten sonra otopark, çay bahçesi ve depo gibi değişik şekillerde kullanılan yapı, 2007 yılında mermer atölyesi olarak kullanılmaya devam etmektedir. Günümüze ulaşan tarihi yapıların korunması ve uygun işlevle yeniden canlandırılması önemli bir konudur. Bu kapsamda öncelikle yapının tarihi ve mimari özelliklerinin belgelemesi yapılmış, ardından yazılı ve görsel belgeler ve yerinde yapılan incelemelere dayanılarak ilk yapım ve kışla dönemi restitüsyon önerileri hazırlanmıştır. Son olarak değişik şekillerde kullanılarak zarar gören tarihi yapının korunması için gereken müdahalelerin tespiti yapılmış ve tarihi ve mimari özelliklerine uygun olarak sosyal ve kültürel bir merkez olarak kullanımını öngören bir restorasyon önerisi hazırlanmıştır., In this study, firstly historical and architectural characteristics of Behram Pasha Han were investigated, its survey was done, and restitution and restoration projects were prepared. The han was founded by Behram Pasha who was the governor of Rum region in the second term of 16th century. Two storeyed building is approximately square in plan and also has a courtyard. The han was constructed for caravans, and it is thought that the first floor of the building was also used for commercial activity. It converted into military barracks at the end of the 19th century and continued to be used by the Ministry of National Defense until 1976. After that the building was used as a car park, cafeteria (tea garden), storage building. In 2007, it is still used by a marble firm. For the purpose of conservation and rehabilitation of the building firstly, documentation of historical and architectural characteristics was done. Then restitution proposals for terms of first construction and military barracks were prepared according to written and visual documents and survey. Lastly, at the scope of the thesis study, essential and suitable conservation processes were determined and then usage of the han as a social and cultural center was stipulated as a restoration proposal., Yüksek Lisans, M.Sc.
- Published
- 2007
16. Response to Cabazitaxel Beyond 20 Cycles in A Patient with Penile Metastasis of Prostate Cancer: A Case Report
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Atag, E., Semiz, H. S., Seher Nazlı Kazaz, Tuna, E. B., Ozdogan, O., Bozkurt, O., Demir, O., and Karaoglu, A.
- Abstract
Penile metastases are extremely rare events and generally occurs at a late stage of primary disease. They mostly originate from prostate and bladder in the genitourinary tract. Penile metastases have a dismal prognosis and very low survival rates. We report a case of penile metastasis in 70-year-old geriatric male patient with prostatic adenocarcinoma who was treated with cabazitaxel chemotherapy beyond 20 cycles with a good response and acceptable minimal toxicity.
17. NIVOLUMAB ASSOCIATED ENDOCRINE ABNORMALITIES: CHALLENGING CASES FROM A REFERENCE CLINIC.
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Unal, M. C., Semiz, G. Güngör, Ozdoğan, O., Altay, C., Yildirim, E. Caliskan, Semiz, H. S., Comlekci, A., and Akinci, B.
- Subjects
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THYROIDITIS , *PROGRAMMED cell death 1 receptors , *IMMUNE checkpoint inhibitors , *NIVOLUMAB , *ENDOCRINE system , *HORMONE receptors - Abstract
Background. Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of advanced cancers. Antibodies directed against programmed cell death receptor 1 (PD-1) interrupt the ability of the cancerous cell to depress the immune system. Methods and results. We report three patients who developed different endocrine abnormalities after treatment with nivolumab, a monoclonal antibody directed against PD-1. First, we report a 76-year-old male presenting with generalized fat loss after treatment with nivolumab which predominantly affected his face and trunk. Second, we described the development of thyroiditis that presented with thyrotoxicosis and the expression of thyroid-stimulating hormone receptor antibodies (TRAb). Finally, we observed the emergence of adrenal insufficiency due to hypophysitis in another case. Conclusion. Although immune checkpoint inhibitors are an effective anticancer treatment modality, adverse effects are evident that can affect the endocrine system. These adverse events may relate to different endocrine systems that include the thyroid and pituitary glands. Also, acquired generalized lipodystrophy should be suspected in patients developing unusual fat loss after treatment with ICIs. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
18. NIVOLUMAB ASSOCIATED ENDOCRINE ABNORMALITIES: CHALLENGING CASES FROM A REFERENCE CLINIC.
- Author
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Unal, M. C., Semiz, G. Güngör, Ozdoğan, O., Altay, C., Yildirim, E. Caliskan, Semiz, H. S., Comlekci, A., and Akinci, B.
- Subjects
- *
THYROIDITIS , *PROGRAMMED cell death 1 receptors , *IMMUNE checkpoint inhibitors , *NIVOLUMAB , *ENDOCRINE system , *HORMONE receptors - Abstract
Background. Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of advanced cancers. Antibodies directed against programmed cell death receptor 1 (PD-1) interrupt the ability of the cancerous cell to depress the immune system. Methods and results. We report three patients who developed different endocrine abnormalities after treatment with nivolumab, a monoclonal antibody directed against PD-1. First, we report a 76-year-old male presenting with generalized fat loss after treatment with nivolumab which predominantly affected his face and trunk. Second, we described the development of thyroiditis that presented with thyrotoxicosis and the expression of thyroid-stimulating hormone receptor antibodies (TRAb). Finally, we observed the emergence of adrenal insufficiency due to hypophysitis in another case. Conclusion. Although immune checkpoint inhibitors are an effective anticancer treatment modality, adverse effects are evident that can affect the endocrine system. These adverse events may relate to different endocrine systems that include the thyroid and pituitary glands. Also, acquired generalized lipodystrophy should be suspected in patients developing unusual fat loss after treatment with ICIs. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
19. Increased circulating interleukin-23 level in patients with sarcoidosis.
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Kobak S, Semiz H, Akyildiz M, Gokduman A, Atabay T, and Vural H
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- Female, Humans, Male, Middle Aged, Cytokines analysis, Interleukin-12 analysis, Interleukin-17, Interleukin-23, Interleukin-6, Arthritis, Sarcoidosis
- Abstract
Background: Sarcoidosis is a Th1-mediated chronic inflammatory disease characterized by non-caseating granulomas. Its pathogenesis is not yet clear, but the possible role of various proinflammatory cytokines is being discussed., Aim: This study aims to determine serum cytokine (IL-6, IL-12, IL-17, and IL-23) levels in patients with sarcoidosis, and to determine a possible correlation with clinical and laboratory findings of the disease., Material and Method: Forty-four biopsy-proven sarcoidosis patients followed up at a single centre and 41 healthy volunteers were included in the study. Demographic, clinical, laboratory, and radiological data of all patients were recorded. Serum samples from the patients and the control group were taken and IL-6, IL-12, IL-17, IL-23 were measured by ELISA method., Results: Of the 44 sarcoidosis patients, 13(29.5%) were male and 31(70.5%) were female. Average patient age was 47.4 years, mean disease duration was 3.2 years. Twenty-one (47.7%) patients had erythema nodosum, three (6.8%) had uveitis, 40(90.9%) had arthralgia, 23(52.3%) had ankle arthritis, 15(34.1%) had enthesitis. Laboratory evaluation showed increased serum ACE levels in 24(54.5%) patients, increased serum calcium levels in 11 (25%) patients, increased serum D3 levels in 5(11.4%) patients, increased ESR and CRP levels in 22(50%) and 23(52.3%) patients, respectively. Compared with the control group higher serum IL-23 levels were found in the patients with sarcoidosis (p=.01). Serum IL-23 was associated with ankle arthritis (p=.02). Serum IL-6, IL-12, and IL-17 levels were similar in the sarcoidosis patients and the control group (p=.128, p=.212, p=.521 respectively)., Conclusion: In our study, we found increased serum IL-23 in patients with sarcoidosis, while serum IL-6, IL-12, and IL-17 were detected as normal. Although our results are somewhat contradictory to other studies in the literature, the question should still be whether sarcoidosis is a Th1/Th17 disease. Multicentre studies are needed in this regard., (Copyright © 2022 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
20. An evaluation of maternal serum dynamic thiol-disulfide homeostasis and ischemia modified albumin changes in pregnant women with COVID-19.
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Erol SA, Anuk AT, Tanaçan A, Semiz H, Keskin HL, Neşelioğlu S, Erel Ö, Moraloğlu Tekin Ö, and Şahin D
- Abstract
Objective: It is thought that oxidative stress, free radicals, reactive oxygen species and reactive nitrogen species affect the pathophysiology of coronavirus disease-2019 (COVID-19). This study aimed to evaluate the oxidative status in pregnant patients with COVID-19 infection according to the changes seen in the levels of maternal serum thiol-disulfide and ischemia-modified albumin (IMA)., Materials and Methods: A study group was formed of 40 pregnant women with confirmed COVID-19 infection (study group) and a control group of 40 healthy pregnant women with no risk factors determined. In this prospective, case-controlled study, analyses were made of the maternal serum native thiol, total thiol, disulfide, IMA, and disulfide/native thiol concentrations., Results: The maternal serum native thiol and total thiol concentrations in the study group were determined to be statistically significantly lower (p=0.007 and p=0.006, respectively), and the disulfide/native thiol ratio was higher but not to a level of statistical significance (p=0.473). There was no difference between the two groups regarding IMA levels (p=0.731)., Conclusion: The thiol-disulfide balance was seen to shift in the oxidant direction in pregnancies with COVID-19, which might support the view that ischemic processes play a role in the etiopathogenesis of this novel disease., Competing Interests: Conflict of Interest: No conflict of interest was declared by the authors., (©Copyright 2022 by Turkish Society of Obstetrics and Gynecology Turkish Journal of Obstetrics and Gynecology published by Galenos Publishing House.)
- Published
- 2022
- Full Text
- View/download PDF
21. Malignancy in patients with sarcoidosis.
- Author
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Kobak S, Yildiz F, Semiz H, and Orman M
- Abstract
The relationship between sarcoidosis and malignancy is not clear yet. We retrospectively evaluated 131 sarcoidosis patients followed-up at the single Rheumatology center. The incidence of malignancies was investigated in this cohort. A total of 6 (4.6%) patients with malignancy were identified in our cohort of 131 patients with sarcoidosis. Hodgkin lymphoma (HL) was detected in three patients, followed by one patient with breast cancer, one patient with thyroid cancer and one patient with testicular cancer. All patients had chronic sarcoidosis with pulmonary involvement, and only 1 patient had acute sarcoidosis with Löfgren's syndrome. HL developed concomitantly with sarcoidosis in one patient while other two patients developed disease before and after sarcoidosis diagnosis. Two patients with solid tumors developed malignancy years before sarcoidosis diagnosis, while one patient developed thyroid cancer during sarcoidosis follow-up. All 6 sarcoidosis-malignancy patients survived after six year years follow up. We found low incidence of malignancy in patients with sarcoidosis in our small cohort. The sarcoidosis-malignancy relationship can only be a coincidence and/or can be explained by a common pathogenesis. New prospective studies involving large patients series are needed in this regard., (Copyright © 2019 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
22. Serum adipokine levels in patients with sarcoidosis.
- Author
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Kobak S, Semiz H, Akyildiz M, Gokduman A, Atabay T, and Vural H
- Subjects
- Adult, Biomarkers blood, Blood Sedimentation, Body Mass Index, C-Reactive Protein metabolism, Case-Control Studies, Female, Humans, Male, Middle Aged, Peptidyl-Dipeptidase A blood, Sarcoidosis pathology, Adiponectin blood, Adipose Tissue metabolism, Leptin blood, Sarcoidosis blood
- Abstract
Background: Sarcoidosis is a chronic inflammatory disease characterized by non-caseating granuloma which etiology is unknown yet. Adipokines are different proteins synthesized by adipose tissue that have an influence on angiogenesis, hemostasis, lipid metabolism, and immune system regulation. Adipokines may play a role in the pathogenesis of sarcoidosis., Objectives: To evaluate the serum adipokine levels in patients with sarcoidosis and to determine a possible correlation with clinical and laboratory signs of disease., Methods: Forty-four biopsy-proven sarcoidosis patients followed at a single center and age- and sex-matched 41 healthy volunteers were included in the study. Demographic, clinical, laboratory, and radiological data were recorded and body mass index (BMI) was calculated in all patients. Routine laboratory tests (blood glucose, liver, and kidney function test) were measured. Serum adiponectin and leptin levels were measured by ELISA method., Results: Among 44sarcoidosis patients, 13 (29.5%) were male and 31 (70.5%) were female. Twenty-one (47.7%) patients had erythema nodosum, three (6.8%) had uveitis, 40 (90.9%) had arthralgia, 32 (72.7%) had arthritis, 15 (34.1%) had enthesitis. Laboratory evaluation showed increased serum ACE level in 24 (54.5%) patients, increased serum calcium level in 11 (25%) patients, increased serum D3 level in 5 (11.4%) patients, and increased ESR and CRP levels in 22 (50%) and 23 (52.3%) patients, respectively. Compared with the control group, serum adiponectin levels were significantly higher in patients with sarcoidosis(p = 0.007). Serum adiponectin level was associated with arthralgia and ankle joint swelling (p = 0.007, p = 0.006 respectively). Serum leptin levels were similar in sarcoidosis patients and controls (p = 0.327). There was no relationship between serum leptin level and disease features (p > 0.05)., Conclusions: In this study, high serum adiponectin level was detected in patients with sarcoidosis while serum leptin level was similar in the sarcoidosis and control group. Adiponectin, an anti-inflammatory protein, may play a role in the pathogenesis of sarcoidosis. Studies are needed to shed light on this topic.Key Points• Sarcoidosis is a chronic granulomatous disease characterized by granuloma formation• High serum adiponectin level was found in sarcoidosis patients• Serum adiponectin level was associated with some clinical features such as arthralgia and arthritis• High adiponectin levels in sarcoidosis patients may mitigate the inflammatory response, resulting in a mild form of the disease and/or spontaneous remission.
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- 2020
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23. Elderly-onset sarcoidosis: A single center comparative study.
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Kobak S, Yildiz F, Semiz H, and Orman M
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- Adult, Age of Onset, Aged, Female, Humans, Male, Middle Aged, Retrospective Studies, Sarcoidosis complications, Sarcoidosis diagnosis
- Abstract
Objectives: Sarcoidosis rarely affect patients older than 65 years old. The purpose of this study is to compare and evaluate the demographic, clinical and laboratory features of elderly-onset (EOS) and young-onset sarcoidosis (YOS) patients., Methods: One hundred and thirty one patients diagnosed with sarcoidosis according to clinical, radiologic and histopathological evaluation were included in this study. The patients with initial symptoms started after age 65 were accepted as EOS., Results: Twenty (15.3%) of 131 patients were diagnosed as EOS, and 111 (84.7%) patients were evaluated as YOS. Fifteen of 20 EOS patients were female and 5 of them were male. Average duration of the disease was determined as 38.4 months for YOS and 22.5 months for EOS (p=0.556). Delay of the diagnosis was 12 months for YOS while it was 3 months for EOS (p=0.001). Higher rates of fatique, comorbid diseases and more hydroxychloroquine (HQ) use were detected in EOS patients comparing to YOS (p=0.010, p=0.003 and p=0.039 respectively)., Conclusions: EOS patients are characterized with higher rates of fatique and comorbid diseases, less inflammatory sign and delayed diagnosis, and less DMARDs use., (Copyright © 2018 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología. All rights reserved.)
- Published
- 2020
- Full Text
- View/download PDF
24. Concomitant Autoimmune Diseases in Patients With Sarcoidosis in Turkey.
- Author
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Yildiz F, Kobak Ş, Semİz H, and Orman M
- Abstract
Objectives: This study aims to determine the frequency and characteristics of autoimmune diseases associated with sarcoidosis patients., Patients and Methods: The study included 131 sarcoidosis patients (36 males, 95 females; mean age 46.1 years; range, 20 to 82 years). Demographic, clinical, laboratory and radiological data of patients were evaluated retrospectively. The characteristics of autoimmune diseases associated with sarcoidosis (sarcoidosis-overlap group) patients and isolated sarcoidosis (isolated sarcoidosis group) were analyzed and compared., Results: Concomitant autoimmune diseases were detected in 15 (11.5%) (5 males, 10 females; mean age 50.8 years; range, 26 to 58 years) of the 131 patients with sarcoidosis and their mean disease duration was three months (range, 1 to 30 months). When compared with isolated sarcoidosis patients, more hand finger joint involvement, rheumatoid factor (RF) positivity, higher erythrocyte sedimentation rate (ESR) and less nonsteroidal anti-inflammatory drugs (NSAIDs) usage were found in the sarcoidosis-overlap group (p=0.035, p=0.049, p=0.015, p=0.018, respectively). There were no statistically significant differences between the two groups when evaluated for demographic, clinical parameters and disease-modifying antirheumatic drugs usage., Conclusion: Concomitant autoimmune diseases in patients with sarcoidosis may be rarely seen. These patients are characterized with more hand finger joint involvement, RF positivity, higher ESR and less NSAIDs usage. Multicenter, prospective studies involving large numbers of patients are needed to understand whether the association of sarcoidosis-autoimmune diseases is based only on coincidence or on a common etiopathogenesis., Competing Interests: Conflict of Interest: The authors declared no conflicts of interest with respect to the authorship and/or publication of this article., (Copyright © 2020, Turkish League Against Rheumatism.)
- Published
- 2020
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25. Ustekinumab-induced Sarcoidosis in a Patient with Psoriatic Arthritis.
- Author
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Kobak S and Semiz H
- Subjects
- Female, Granuloma pathology, Humans, Middle Aged, Thorax pathology, Arthritis, Psoriatic drug therapy, Sarcoidosis chemically induced, Ustekinumab adverse effects
- Abstract
Background: Psoriatic Arthritis (PsA) is a chronic inflammatory disease that may affect different joints. Sarcoidosis is a Th-1 cell-related chronic granulomatous disease characterized by non-caseating granuloma formation. The coexistence of both the diseases is a rare entity. Ustekinumab, an IL12 / 23 inhibitor, has shown efficacy and safety in the treatment of PsA., Objective: This study presents a case with ustekinumab-induced sarcoidosis in a patient with PsA., Case Report: A 52 years old female patient with complaints of pain and swelling of the wrists, MCP, PIP and DIP joints and skin lesions was referred to our Rheumatology clinic. On her medical history, she had been under follow up for 5 years with the diagnosis of psoriasis and one year ago, she started to receive ustekinumab prescribed by a dermatologist. On physical examination, she had psoriasis skin lesions and arthritis of both wrists, MCP, PIP, DIP joints. Bilateral hilar lymphadenopathies were detected in the chest X-ray and thorax computed tomography. In laboratory tests, acute phase reactants and serum angiotensin-converting enzyme levels were high. Endobronchial ultrasonography biopsy was performed and non-caseating granuloma consistent with sarcoidosis was reported. Ustekinumab was discontinued, methotrexate and low-dose corticosteroid were started. The patient was clinically stable in the 6th month of the treatment and the findings were regressed., Conclusion: Sarcoidosis development appears to be a new paradoxical effect of ustekinumab therapy, being another biological agent., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
- Published
- 2020
- Full Text
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26. Coexistence of Sarcoidosis and Gouty Arthritis.
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Semiz H and Kobak S
- Subjects
- Humans, Male, Middle Aged, Arthritis, Gouty complications, Sarcoidosis complications
- Abstract
Sarcoidosis is an inflammatory disease with unknown cause characterized by non-caseating granuloma formations. It may present with bilateral hilar lymphadenopathy, skin lesions, the involvement of eye and symptoms on the locomotor system. Gouty arthritis is an autoinflammatory disease characterized by hyperuricemia, recurrent arthritis attacks and the deposition of monosodium urate crystals in the joints and the surrounding tissues. We reported the coexistence of sarcoidosis and gouty arthritis in this paper., (Copyright © 2017 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología. All rights reserved.)
- Published
- 2019
- Full Text
- View/download PDF
27. Coexistence of sarcoidosis and adult onset Still disease.
- Author
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Semiz H and Kobak S
- Subjects
- Antibodies, Monoclonal, Humanized therapeutic use, Humans, Immunosuppressive Agents therapeutic use, Male, Methotrexate therapeutic use, Sarcoidosis, Pulmonary diagnostic imaging, Sarcoidosis, Pulmonary drug therapy, Still's Disease, Adult-Onset drug therapy, Tomography, X-Ray Computed, Young Adult, Sarcoidosis, Pulmonary complications, Still's Disease, Adult-Onset complications
- Abstract
Sarcoidosis is a chronic, inflammatory disease with unknown cause characterized by non-caseating granuloma formations. It can be presented with bilateral hilar lymphadenopathy, skin lesions, eye involvement and locomotor system findings. Adult onset Still disease (AOSD) is a chronic inflammatory disease which presents with fever, arthritis and typical skin rashes. The disease is rare and can be misdiagnosed due to the absence of typical clinical and laboratory findings. The association of sarcoidosis and AOSD has not been previously reported in the literature. Herein we reported the development of AOSD in a patient followed by the diagnosis of sarcoidosis. The patient did not respond to high-dose corticosteroids and methotrexate therapy, and the disease was under control with anti-IL-6 (Tocilizumab) drug., (Copyright © 2017 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología. All rights reserved.)
- Published
- 2019
- Full Text
- View/download PDF
28. Hyponatremia as presentation in a patient with neurosarcoidosis.
- Author
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Akyildiz E, Yalcin M, Sever F, Semiz H, and Kobak S
- Subjects
- Central Nervous System Diseases blood, Central Nervous System Diseases diagnostic imaging, Female, Fluid Therapy, Humans, Hyponatremia drug therapy, Hyponatremia therapy, Middle Aged, Neuroimaging, Prednisone therapeutic use, Sarcoidosis blood, Sarcoidosis diagnostic imaging, Sodium therapeutic use, Central Nervous System Diseases complications, Hyponatremia etiology, Sarcoidosis complications
- Abstract
Sarcoidosis is an inflammatory disease with unknown cause characterized by non-caseating granuloma formations. It may present with bilateral hilar lymphadenopathy, skin lesions, eye and musculoskeletal system involvement. Hypercalcemia and hypercalciuria are important electrolyte imbalances resulting from sarcoidosis and sometimes they may cause nephrolitiasis and kidney failure. Hyponatremia, although being quite rare, has been found in some patients with sarcoidosis. Herein, we have reported a patient with neurosarcoidosis who presented with hyponatremia and responded well to corticosteroid treatment., (Copyright © 2016 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología. All rights reserved.)
- Published
- 2017
- Full Text
- View/download PDF
29. Characteristics of Turkish patients with elderly onset psoriatic arthritis: A retrospective cohort study.
- Author
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Kobak S, Yildiz F, Karaarslan A, Semiz H, and Orman M
- Subjects
- Adolescent, Adult, Age of Onset, Aged, Arthritis, Psoriatic drug therapy, Comorbidity, Female, Humans, Male, Middle Aged, Retrospective Studies, Young Adult, Arthritis, Psoriatic physiopathology
- Abstract
Psoriatic arthritis (PsA) is a chronic inflamatory disease characterized with axial and peripheral joints involvement. It rarely affects patients older than 65 years old.The purpose of this study is to compare and evaluate the demographic, clinical and laboratory features of elderly-onset psoriatic arthritis (EOPsA) and young-onset (YOPsA) patients.A total of 180 patients diagnosed with PsA according to CASPAR criteria and followed-up in single center were included in this study. The patients with initial symptoms started after age 65 were accepted as EOPsA. Demographic, clinic, and laboratory data and the medications which the patients received were recorded and retrospectively evaluated.Nineteen (10.5%) of 180 patients were diagnosed as EOPsA, and 161 (89.5%) patients were evaluated as YOPsA. The mean patient age was 42.1years for the YOPsA group and 68.3 years for the elderly onset group. Mean duration of disease was 5.6 years for the early onset group and 1.3 years for the elderly onset group (P = .001). Fourteen (73.3%) of 19 EOPsA patients were female and 5 of them were male. Higher rates of fatique, pain scores, comorbid diseases, and acute phase reactants elevation were detected in EOPsA patients comparing to YOPsA (P = .000, P = .000, P = .001, and P = .001, respectively). YOPsA patients have more dactilitis, nail involvement, elevated PASI scores, and smoking habitus when compared with EOPsA patients (P = .019, P = .03, P = .005, P = .004, respectively). In terms of the treatment options chosen, there was no significant difference in the use of nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids (CS), methotrexate (MTX), and sulfasalazine (SSL), but there was a more frequent use of anti-tumor necrosis factor-alpha in the YOPsA group.YOPsA and EOPsA patients may presented with different clinical and laboratory features. EOPsA patients are characterized with higher rates of fatigue, pain scores, comorbid diseases, and acute phase reactants and less dactilitis, nail involvement, and anti-TNF-alpha usage.
- Published
- 2017
- Full Text
- View/download PDF
30. Coexistence of sarcoidosis and Familial Mediterranean Fever.
- Author
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Semiz H and Kobak S
- Subjects
- Familial Mediterranean Fever diagnosis, Female, Humans, Middle Aged, Sarcoidosis diagnosis, Familial Mediterranean Fever complications, Sarcoidosis complications
- Abstract
Sarcoidosis is a chronic inflammatory disease with unknown cause characterized by non-caseating granuloma formations. It may present with bilateral hilar lymphadenopathy, skin lesions, the involvement of eye and symptoms on the locomotor system. FMF (Familial Mediterranean Fever) is an autosomal recessive autoinflammatory disease, characterized by recurrent episodes of fever and polyserositis. Simultaneous occurrence of these diseases is rare. In this paper, we reported the coexistence of sarcoidosis with FMF., (Copyright © 2016 Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología. All rights reserved.)
- Published
- 2017
- Full Text
- View/download PDF
31. Sarcoidosis presenting as penile mass.
- Author
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Semiz H and Kobak S
- Abstract
Sarcoidosis is an inflammatory disease with unknown cause characterized by noncaseating granuloma formations. It may present with bilateral hilar lymphadenopathy, skin lesions, eye, and musculoskeletal system involvement. Rare involvement of the genital organs (prostate, testis, epididymis) has also been reported. However, penile involvement is observed quite rare. In this paper, we report a patient with penile mass who was diagnosed with sarcoidosis on the basis of the laboratory, radiological, and pathological investigations.
- Published
- 2017
- Full Text
- View/download PDF
32. Comorbidity of sarcoidosis and Graves' disease.
- Author
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Semiz H, Kobak S, Sever F, and Karadeniz M
- Subjects
- Adult, Female, Graves Disease diagnosis, Humans, Sarcoidosis diagnosis, Graves Disease complications, Sarcoidosis complications
- Published
- 2016
- Full Text
- View/download PDF
33. The injection of air/oxygen bubble into the anterior chamber of rabbits as a treatment for hyphema in patients with sickle cell disease.
- Author
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Ayintap E, Keskin U, Sadigov F, Coskun M, Ilhan N, Motor S, Semiz H, and Parlakfikirer N
- Abstract
Purpose. To investigate the changes of partial oxygen pressure (PaO2) in aqueous humour after injecting air or oxygen bubble into the anterior chamber in sickle cell hyphema. Methods. Blood samples were taken from the same patient with sickle cell disease. Thirty-two rabbits were divided into 4 groups. In group 1 (n = 8), there was no injection. Only blood injection constituted group 2 (n = 8), both blood and air bubble injection constituted group 3 (n = 8), and both blood and oxygen bubble injection constituted group 4 (n = 8). Results. The PaO2 in the aqueous humour after 10 hours from the injections was 78.45 ± 9.9 mmHg (Mean ± SD) for group 1, 73.97 ± 8.86 mmHg for group 2, 123.35 ± 13.6 mmHg for group 3, and 306.47 ± 16.5 mmHg for group 4. There was statistically significant difference between group 1 and group 2, when compared with group 3 and group 4. Conclusions. PaO2 in aqueous humour was increased after injecting air or oxygen bubble into the anterior chamber. We offer to leave an air bubble in the anterior chamber of patients with sickle cell hemoglobinopathies and hyphema undergoing an anterior chamber washout.
- Published
- 2014
- Full Text
- View/download PDF
34. Central retinal artery occlusion secondary to orbital cellulitis and abscess following dacryocystitis.
- Author
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Coşkun M, Ilhan Ö, Keskin U, Ayintap E, Tuzcu E, Semiz H, and Öksüz H
- Subjects
- Abscess diagnosis, Abscess drug therapy, Amikacin therapeutic use, Anti-Bacterial Agents therapeutic use, Blindness etiology, Dacryocystitis diagnosis, Dacryocystitis drug therapy, Drug Therapy, Combination, Eye Infections, Bacterial diagnosis, Eye Infections, Bacterial drug therapy, Female, Fluorescein Angiography, Humans, Magnetic Resonance Imaging, Meropenem, Middle Aged, Orbital Cellulitis diagnosis, Orbital Cellulitis drug therapy, Retinal Artery Occlusion diagnosis, Staphylococcal Infections diagnosis, Staphylococcal Infections drug therapy, Thienamycins therapeutic use, Abscess complications, Dacryocystitis complications, Eye Infections, Bacterial complications, Orbital Cellulitis complications, Retinal Artery Occlusion etiology, Staphylococcal Infections complications
- Abstract
Purpose: To report a case of dacryocystitis that progressed to orbital abscess resulting in the rare complication of central retinal artery occlusion., Methods: A patient without any other known health problems presented with dacryocystitis complicated by orbital cellulitis, orbital abscess, and finally central retinal artery occlusion despite medical treatment., Results: After 48 hours of medical treatment, there was no recovery, and there was loss of light perception; because of this, surgery indication was determined. Fundus fluorescein angiogram demonstrated findings of central retinal artery occlusion. There was no recovery of light perception after surgical intervention., Conclusions: We report a case of orbital abscess following dacryocystitis in a healthy middle-aged woman resulting in the rare complication of central retinal artery occlusion. To our knowledge, this is the first report of central retinal artery occlusion secondary to orbital abscess following dacryocystitis.
- Published
- 2011
- Full Text
- View/download PDF
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