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The exploration of topologically-ordered states of matter is a long-standing goal at the interface of several subfields of the physical sciences. Such states feature intriguing physical properties such as long-range entanglement, emergent gauge fields and non-local correlations, and can aid in realization of scalable fault-tolerant quantum computation. However, these same features also make creation, detection, and characterization of topologically-ordered states particularly challenging. Motivated by recent experimental demonstrations, we introduce a paradigm for quantifying topological states-locally error-corrected decoration (LED)-by combining methods of error correction with ideas of renormalization-group flow. Our approach allows for efficient and robust identification of topological order, and is applicable in the presence of incoherent noise sources, making it particularly suitable for realistic experiments. We demonstrate the power of LED using numerical simulations of the toric code under a variety of perturbations. We subsequently apply it to an experimental realization, providing new insights into a quantum spin liquid created on a Rydberg-atom simulator. Finally, we extend LED to generic topological phases, including those with non-abelian order., (© 2024. The Author(s).)

Suppressing errors is the central challenge for useful quantum computing 1 , requiring quantum error correction (QEC) 2-6 for large-scale processing. However, the overhead in the realization of error-corrected 'logical' qubits, in which information is encoded across many physical qubits for redundancy 2-4 , poses substantial challenges to large-scale logical quantum computing. Here we report the realization of a programmable quantum processor based on encoded logical qubits operating with up to 280 physical qubits. Using logical-level control and a zoned architecture in reconfigurable neutral-atom arrays 7 , our system combines high two-qubit gate fidelities 8 , arbitrary connectivity 7,9 , as well as fully programmable single-qubit rotations and mid-circuit readout 10-15 . Operating this logical processor with various types of encoding, we demonstrate improvement of a two-qubit logic gate by scaling surface-code 6 distance from d = 3 to d = 7, preparation of colour-code qubits with break-even fidelities 5 , fault-tolerant creation of logical Greenberger-Horne-Zeilinger (GHZ) states and feedforward entanglement teleportation, as well as operation of 40 colour-code qubits. Finally, using 3D [[8,3,2]] code blocks 16,17 , we realize computationally complex sampling circuits 18 with up to 48 logical qubits entangled with hypercube connectivity 19 with 228 logical two-qubit gates and 48 logical CCZ gates 20 . We find that this logical encoding substantially improves algorithmic performance with error detection, outperforming physical-qubit fidelities at both cross-entropy benchmarking and quantum simulations of fast scrambling 21,22 . These results herald the advent of early error-corrected quantum computation and chart a path towards large-scale logical processors., (© 2023. The Author(s).)

The ability to perform entangling quantum operations with low error rates in a scalable fashion is a central element of useful quantum information processing 1 . Neutral-atom arrays have recently emerged as a promising quantum computing platform, featuring coherent control over hundreds of qubits 2,3 and any-to-any gate connectivity in a flexible, dynamically reconfigurable architecture 4 . The main outstanding challenge has been to reduce errors in entangling operations mediated through Rydberg interactions 5 . Here we report the realization of two-qubit entangling gates with 99.5% fidelity on up to 60 atoms in parallel, surpassing the surface-code threshold for error correction 6,7 . Our method uses fast, single-pulse gates based on optimal control 8 , atomic dark states to reduce scattering 9 and improvements to Rydberg excitation and atom cooling. We benchmark fidelity using several methods based on repeated gate applications 10,11 , characterize the physical error sources and outline future improvements. Finally, we generalize our method to design entangling gates involving a higher number of qubits, which we demonstrate by realizing low-error three-qubit gates 12,13 . By enabling high-fidelity operation in a scalable, highly connected system, these advances lay the groundwork for large-scale implementation of quantum algorithms 14 , error-corrected circuits 7 and digital simulations 15 ., (© 2023. The Author(s).)

The ability to engineer parallel, programmable operations between desired qubits within a quantum processor is key for building scalable quantum information systems 1,2 . In most state-of-the-art approaches, qubits interact locally, constrained by the connectivity associated with their fixed spatial layout. Here we demonstrate a quantum processor with dynamic, non-local connectivity, in which entangled qubits are coherently transported in a highly parallel manner across two spatial dimensions, between layers of single- and two-qubit operations. Our approach makes use of neutral atom arrays trapped and transported by optical tweezers; hyperfine states are used for robust quantum information storage, and excitation into Rydberg states is used for entanglement generation 3-5 . We use this architecture to realize programmable generation of entangled graph states, such as cluster states and a seven-qubit Steane code state 6,7 . Furthermore, we shuttle entangled ancilla arrays to realize a surface code state with thirteen data and six ancillary qubits 8 and a toric code state on a torus with sixteen data and eight ancillary qubits 9 . Finally, we use this architecture to realize a hybrid analogue-digital evolution 2 and use it for measuring entanglement entropy in quantum simulations 10-12 , experimentally observing non-monotonic entanglement dynamics associated with quantum many-body scars 13,14 . Realizing a long-standing goal, these results provide a route towards scalable quantum processing and enable applications ranging from simulation to metrology., (© 2022. The Author(s).)

Motivated by far-reaching applications ranging from quantum simulations of complex processes in physics and chemistry to quantum information processing 1 , a broad effort is currently underway to build large-scale programmable quantum systems. Such systems provide insights into strongly correlated quantum matter 2-6 , while at the same time enabling new methods for computation 7-10 and metrology 11 . Here we demonstrate a programmable quantum simulator based on deterministically prepared two-dimensional arrays of neutral atoms, featuring strong interactions controlled by coherent atomic excitation into Rydberg states 12 . Using this approach, we realize a quantum spin model with tunable interactions for system sizes ranging from 64 to 256 qubits. We benchmark the system by characterizing high-fidelity antiferromagnetically ordered states and demonstrating quantum critical dynamics consistent with an Ising quantum phase transition in (2 + 1) dimensions 13 . We then create and study several new quantum phases that arise from the interplay between interactions and coherent laser excitation 14 , experimentally map the phase diagram and investigate the role of quantum fluctuations. Offering a new lens into the study of complex quantum matter, these observations pave the way for investigations of exotic quantum phases, non-equilibrium entanglement dynamics and hardware-efficient realization of quantum algorithms.

Acadesine (ACA), a pharmacological activator of AMP-activated protein kinase (AMPK), showed a promising beneficial effect in a mouse model of colitis, indicating this drug as an alternative tool to manage IBDs. However, ACA displays some pharmacodynamic limitations precluding its therapeutical applications. Our study was aimed at evaluating the in vitro and in vivo effects of FA-5 (a novel direct AMPK activator synthesized in our laboratories) in an experimental model of colitis in rats. A set of experiments evaluated the ability of FA5 to activate AMPK and to compare the efficacy of FA5 with ACA in an experimental model of colitis. The effects of FA-5, ACA, or dexamethasone were tested in rats with 2,4-dinitrobenzenesulfonic acid (DNBS)-induced colitis to assess systemic and tissue inflammatory parameters. In in vitro experiments, FA5 induced phosphorylation, and thus the activation, of AMPK, contextually to the activation of SIRT-1. In vivo, FA5 counteracted the increase in spleen weight, improved the colon length, ameliorated macroscopic damage score, and reduced TNF and MDA tissue levels in DNBS-treated rats. Of note, FA-5 displayed an increased anti-inflammatory efficacy as compared with ACA. The novel AMPK activator FA-5 displays an improved anti-inflammatory efficacy representing a promising pharmacological tool against bowel inflammation.

We report the implementation of universal two- and three-qubit entangling gates on neutral-atom qubits encoded in long-lived hyperfine ground states. The gates are mediated by excitation to strongly interacting Rydberg states and are implemented in parallel on several clusters of atoms in a one-dimensional array of optical tweezers. Specifically, we realize the controlled-phase gate, enacted by a novel, fast protocol involving only global coupling of two qubits to Rydberg states. We benchmark this operation by preparing Bell states with fidelity F≥95.0(2)%, and extract gate fidelity ≥97.4(3)%, averaged across five atom pairs. In addition, we report a proof-of-principle implementation of the three-qubit Toffoli gate, in which two control atoms simultaneously constrain the behavior of one target atom. These experiments demonstrate key ingredients for high-fidelity quantum information processing in a scalable neutral-atom platform.

We report on the study of binary collisions between quantum droplets formed by an attractive mixture of ultracold atoms. We distinguish two main outcomes of the collision, i.e., merging and separation, depending on the velocity of the colliding pair. The critical velocity v_{c} that discriminates between the two cases displays a different dependence on the atom number N for small and large droplets. By comparing our experimental results with numerical simulations, we show that the nonmonotonic behavior of v_{c}(N) is due to the crossover from a compressible to an incompressible regime, where the collisional dynamics is governed by different energy scales, i.e., the droplet binding energy and the surface tension. These results also provide the first evidence of the liquidlike nature of quantum droplets in the large N limit, where their behavior closely resembles that of classical liquid droplets.

We measure the critical scattering length for the appearance of the first three-body bound state, or Efimov three-body parameter, at seven different Feshbach resonances in ultracold ^{39}K atoms. We study both intermediate and narrow resonances, where the three-body spectrum is expected to be determined by the nonuniversal coupling of two scattering channels. Instead, our observed ratio of the three-body parameter with the van der Waals radius is approximately the same universal ratio as for broader resonances. This unexpected observation suggests the presence of a new regime for three-body scattering at narrow resonances.