Search

Amaç: Bu çalışmanın amacı, polikistik over sendromlu (PKOS) kadınların eksfoliyatif servikal hücrelerinde ve periferik kan lenfositlerinde mikronükleus (MN) frekanslarını belirlemektir. Gereç ve Yöntemler: PKOS'li 15 hasta ve 11 sağlıklı kontrol hastası çalışmaya dahil edildi. Tüm hastalardan servikal smearleri ve periferik kan toplandı. Numuneler, MN frekansları açısından analiz edildi ve gruplar arasında karşılaştırıldı. Hem MN sıklığı, hem de genotoksisite ve sitotoksite bağlı diğer nükleer anomaliler değerlendirildi. Bulgular: Servikal smear ve periferik kan lenfositlerinde MN frekansları PKOS hastaları ve normal kontrollerde karşılaştırıldı. Periferik kan lenfositlerinde MN frekansı açısından gruplar arasında istatistiksel olarak anlamlı fark yoktu (p0,239). PKOS hastalarının eksfoliyatif servikal hücrelerindeki ortalama MN skorları ve normal kontrollerinki sırasıyla 1,190,57 ve 0,740,34 idi. Servikal hücrelerdeki MN frekansları istatistiksel olarak gruplar arasında anlamlıydı (p0,032). Sonuç: Çalışma grubu küçük olmasına rağmen çalışma sonuçlarımız, PKOS hastalarının eksfoliyatif hücrelerinde, hastalıkta genetik tehlikenin belirleyicisi olan MN sıklığının arttığını desteklemektedir., Objective: The aim of this study was to determine micronucleus (MN) frequencies in exfoliated cervical cells and peripheral blood lymphocytes of women with polycystic ovarian syndrome (PCOS). Materials and Methods: Fifteen patients with PCOS and 11 healthy control patients were included in the study. Cervical smears and peripheral blood were collected from all patients. Specimens were analyzed for MN frequencies and compared between the groups. In addition to MN, other nuclear anomalies connected with both genotoxicity and cytotoxicity were evaluated.Results: The MN frequencies in cervical smear and peripheral blood lymphocytes were compared in patients with PCOS and normal controls. There was no statistically significant difference between the groups regarding micronucleus frequency in peripheral blood lymphocytes (p0.239). The mean MN scores in exfoliated cervical cells of patients with PCOS and normal controls were 1.190.57 and 0.740.34, respectively. The difference regarding micronucleus frequencies in cervical cells was statistically significant between the groups (p0.032).Conclusion: Although study group is small, our study results support that there is an increased micronucleus frequency in cervical exfoliated cells of PCOS patients; this is a determinant of genetic hazard in the disease.

Bu çalışma yaşlı bireylerintelevizyon izleme oranlarına ve izlenilen programların kaygı ve depresyondüzeylerine etkisini belirlemek amacı ile yapılmıştır. Tanımlayıcı olarakgerçekleştirilen bu araştırma Isparta ili Merkez ilçede yaşayan 60 yaş üstükadınlar oluşturmuştur. Örneklemi araştırmaya katılmayı kabul eden 218 kadınoluşturmaktadır. Yaşlıların tanımlayıcı özelliklerini içeren form, televizyonizleme nedenlerinin sorgulandığı form ve Durumluk-Sürekli Kaygı Envanterikullanılmıştır. Yaşlılardan %43.6’sı 70-79yaş arasında ve günde ortalama televizyon izleme süresi 5.83±1.79 saat olarakbulunmuştur. Tüm vakaların Durumluluk Kaygı Ölçeğinden aldıkları puan46.31±6.34’dır. Televizyonizleyenlerle (%95.87), izlemeyenlerin (%4.13) arasında Durumluluk Kaygı Ölçeğiile istatistiksel açıdan anlamlı ilişki bulunmuştur (p

Objective: The objective of this study was to investigate the risk factors of maternal mortality in Konya province, as well as the preventability of deaths in cases where the central and local commissions differed in their decisions. Material and Methods: Maternal mortality between 2009 and 2014 in the Konya province was screened for the cases, where the central and local Maternal Mortality Investigation Commissions gave different decisions. These differences pertain to whether the deaths were ‘preventable’ or ‘not-preventable’, differences in the first, second and third delay models, and indirect, direct and incidental deaths. The data were evaluated electronically along with a descriptive statistical analysis, differences in the decisions and compliance in the mortality rates were evaluated. Results: The median age of the deceased mothers was 28 (21–44) years and 83.3% of the mothers had at least one mortality risk factor. While the overall maternal mortality rate was 36.7% within the first 48 h after birth, the rates were highest within the first 48 h after birth (26.7%) and between the 1st and 42nd day after birth (26.7%) in indifferently assessed cases. The cause in 30% of all deaths and 33.3% of deaths with differential assessments was postpartum hemorrhage, as per the results of central Maternal Mortality Investigation Commissions. The decisions of the central and local commissions differed in terms of preventability, delay models or death classification in 50% of the deaths. Taken together, the compliance between central and local decisions was not precise in investigating maternal mortality. Conclusion: The first 48 h after birth and the postpartum period are particularly critical. The causes of death, particularly postpartum hemorrhage, should be thoroughly investigated. We recommend periodic re-evaluations of cases where different decisions were made, in order to lower the rate of preventable maternal mortality. Copyright © 2018 by Türkiye Klinikleri.

The technique review by Arendt and Segal1 in the Spring 2008 issue of Reviews in Obstetrics & Gynecology gives us broad insight on various causes of epidural analgesia failure. We would like to comment on the subject and share our experience.