Search

Your search keyword '"Sellers, Stephanie A."' showing total 579 results
Start Over Author "Sellers, Stephanie A."
579 results on '"Sellers, Stephanie A."'

5. Bypass Grafting and Native Coronary Artery Disease Activity

Author

Kwiecinski, Jacek, Tzolos, Evangelos, Fletcher, Alexander J, Nash, Jennifer, Meah, Mohammed N, Cadet, Sebastien, Adamson, Philip D, Grodecki, Kajetan, Joshi, Nikhil, Williams, Michelle C, van Beek, Edwin JR, Lai, Chi, Tavares, Adriana AS, MacAskill, Mark G, Dey, Damini, Baker, Andrew H, Leipsic, Jonathon, Berman, Daniel S, Sellers, Stephanie L, Newby, David E, Dweck, Marc R, and Slomka, Piotr J

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Heart Disease - Coronary Heart Disease, Atherosclerosis, Cardiovascular, Heart Disease, Clinical Research, Aged, Calcinosis, Calcium, Coronary Angiography, Coronary Artery Disease, Disease Progression, Female, Humans, Male, Middle Aged, Plaque, Atherosclerotic, Predictive Value of Tests, Sodium Fluoride, F-18-NaF, CABG, coronary artery bypass graft, coronary artery disease, PET/CT, (18)F-NaF, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

ObjectivesThe aim of this study was to describe the potential of 18F-sodium fluoride (18F-NaF) positron emission tomography (PET) to identify graft vasculopathy and to investigate the influence of coronary artery bypass graft (CABG) surgery on native coronary artery disease activity and progression.BackgroundAs well as developing graft vasculopathy, CABGs have been proposed to accelerate native coronary atherosclerosis.MethodsPatients with established coronary artery disease underwent baseline 18F-NaF PET, coronary artery calcium scoring, coronary computed tomographic angiography, and 1-year repeat coronary artery calcium scoring. Whole-vessel coronary microcalcification activity (CMA) on 18F-NaF PET and change in calcium scores were quantified in patients with and without CABG surgery.ResultsAmong 293 participants (mean age 65 ± 9 years, 84% men), 48 (16%) underwent CABG surgery 2.7 years [IQR: 1.4-10.4 years] previously. Although all arterial and the majority (120 of 128 [94%]) of vein grafts showed no 18F-NaF uptake, 8 saphenous vein grafts in 7 subjects had detectable CMA. Bypassed native coronary arteries had 3 times higher CMA values (2.1 [IQR: 0.4-7.5] vs 0.6 [IQR: 0-2.7]; P < 0.001) and greater progression of 1-year calcium scores (118 Agatston unit [IQR: 48-194 Agatston unit] vs 69 [IQR: 21-142 Agatston unit]; P = 0.01) compared with patients who had not undergone CABG, an effect confined largely to native coronary plaques proximal to the graft anastomosis. In sensitivity analysis, bypassed native coronary arteries had higher CMA (2.0 [IQR: 0.4-7.5] vs 0.8 [IQR: 0.3-3.2]; P < 0.001) and faster disease progression (24% [IQR: 16%-43%] vs 8% [IQR: 0%-24%]; P = 0.002) than matched patients (n = 48) with comparable burdens of coronary artery disease and cardiovascular comorbidities in the absence of bypass grafting.ConclusionsNative coronary arteries that have been bypassed demonstrate increased disease activity and more rapid disease progression than nonbypassed arteries, an observation that appears independent of baseline atherosclerotic plaque burden. Microcalcification activity is not a dominant feature of graft vasculopathy.

Published
2022

6. Aspirin and Statin Therapy for Nonobstructive Coronary Artery Disease: Five-year Outcomes from the CONFIRM Registry

Author

Indraratna, Praveen, Naoum, Christopher, Ben Zekry, Sagit, Gransar, Heidi, Blanke, Philipp, Sellers, Stephanie, Achenbach, Stephan, Al-Mallah, Mouaz H, Andreini, Daniele, Berman, Daniel S, Budoff, Matthew J, Cademartiri, Filippo, Callister, Tracy Q, Chang, Hyuk-Jae, Chinnaiyan, Kavitha, Chow, Benjamin JW, Cury, Ricardo C, DeLago, Augustin, Feuchtner, Gudrun, Hadamitzky, Martin, Hausleiter, Joerg, Kaufmann, Philipp A, Kim, Yong-Jin, Maffei, Erica, Marques, Hugo, Gonçalves, Pedro de Araújo, Pontone, Gianluca, Raff, Gilbert L, Rubinshtein, Ronen, Villines, Todd C, Lin, Fay Y, Shaw, Leslee J, Narula, Jagat, Bax, Jeroen J, and Leipsic, Jonathon A

Subjects
Epidemiology, Biomedical and Clinical Sciences, Health Sciences, Clinical Research, Cardiovascular, Heart Disease - Coronary Heart Disease, Heart Disease, Clinical Trials and Supportive Activities, Atherosclerosis, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Good Health and Well Being, Aspirin, CT Angiography, Coronary Artery Disease, Nonobstructive Coronary Artery Disease, Statin
Abstract

PurposeIn this cohort study, 5-year data from the Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter Registry (ie, CONFIRM) were examined to identify associations of baseline aspirin and statin use with mortality, major adverse cardiovascular events (MACE), and myocardial infarction (MI) in individuals without substantial (≥50%) stenosis.Materials and methodsIn this prospective cohort study, all participants in the registry underwent coronary CT angiography and were classified as having no detectable coronary plaque or having nonobstructive coronary artery disease (CAD) (1%-49% stenosis). Participants with obstructive (≥50%) stenosis were excluded from analysis. The study commenced in June 2003 and was completed in March 2016. All unadjusted and risk-adjusted analyses utilized the Cox proportional hazard model with hospital sites modeled using shared frailty.ResultsA total of 6386 participants with no detectable plaque or with nonobstructive CAD were included (mean age, 56.0 years ± 13.3 [SD], 52% men). The mean follow-up period was 5.66 years ± 1.10. Nonobstructive CAD (n = 2815, 44% of all participants included in the study) was associated with a greater risk of all-cause mortality (10.6% [298 of 2815] vs 4.8% [170 of 3571], P < .001) compared to those without CAD (n = 3571, 56%). Baseline aspirin and statin use was documented for 1415 and 1429 participants, respectively, with nonobstructive CAD, and for 1560 and 1565 participants without detectable plaque, respectively. In individuals with nonobstructive CAD, baseline aspirin use was not associated with a reduction in MACE (10.9% [102 of 936] vs 14.7% [52 of 355], P = .06), all-cause mortality (9.6% [95 of 991] vs 10.9% [46 of 424], P = .468), or MI (4.4% [41 of 936] vs 6.2% [22 of 355], P = .18). On multivariate risk-adjusted analysis, baseline statin use was associated with a lower rate of MACE (hazard ratio, 0.59; 95% CI: 0.40, 0.87; P = .007). Neither therapy improved clinical outcomes for participants with no detectable plaque.ConclusionIn participants with nonobstructive CAD, baseline use of statins, but not of aspirin, was associated with improved clinical outcomes. Neither therapy was associated with benefit in participants without plaque.Keywords: Aspirin, Statin, Coronary Artery Disease, CT Angiography, Nonobstructive Coronary Artery DiseaseClinical trial registration no. NCT01443637 Supplemental material is available for this article. © RSNA, 2022See also the commentary by Canan and Navar in this issue.

Published
2022

7. Feasibility and Utility of Anatomical and Physiological Evaluation of Coronary Disease With Cardiac CT in Severe Aortic Stenosis (FUTURE-AS Registry): Rationale and Design

Author

Khoo, John King, Sellers, Stephanie, Fairbairn, Timothy, Polsani, Venkateshwar, Liu, Shizhen, Yong, Gerald, Shetty, Sharad, Corrigan, Frank, Ko, Brian, Vucic, Esad, Fitzgibbons, Timothy P., Kakouros, Nikolaos, Blanke, Philipp, Sathananthan, Janarthanan, Webb, John, Wood, David, Leipsic, Jonathon, and Ihdayhid, Abdul Rahman

Published
2024
Full Text
View/download PDF

10. Effects of renin-angiotensin-aldosterone-system inhibitors on coronary atherosclerotic plaques: The PARADIGM registry

Author

Williams, Curtis, Han, Donghee, Takagi, Hidenobu, Fordyce, Christopher B., Sellers, Stephanie, Blanke, Philipp, Lin, Fay Y., Shaw, Leslee J., Lee, Sang-Eun, Andreini, Daniele, Al-Mallah, Mouaz H., Budoff, Matthew J., Cademartiri, Filippo, Chinnaiyan, Kavitha, Choi, Jung Hyun, Conte, Edoardo, Marques, Hugo, de Araújo Gonçalves, Pedro, Gottlieb, Ilan, Hadamitzky, Martin, Maffei, Erica, Pontone, Gianluca, Shin, Sanghoon, Kim, Yong-Jin, Lee, Byoung Kwon, Chun, Eun Ju, Sung, Ji Min, Virmani, Renu, Samady, Habib, Stone, Peter H., Berman, Daniel S., Narula, Jagat, Bax, Jeroen J., Leipsic, Jonathon A., and Chang, Hyuk-Jae

Published
2023
Full Text
View/download PDF

11. The Relationship Between Coronary Calcification and the Natural History of Coronary Artery Disease

Author

Jin, Han-Young, Weir-McCall, Jonathan R, Leipsic, Jonathon A, Son, Jang-Won, Sellers, Stephanie L, Shao, Michael, Blanke, Philipp, Ahmadi, Amir, Hadamitzky, Martin, Kim, Yong-Jin, Conte, Edoardo, Andreini, Daniele, Pontone, Gianluca, Budoff, Matthew J, Gottlieb, Ilan, Lee, Byoung Kwon, Chun, Eun Ju, Cademartiri, Filippo, Maffei, Erica, Marques, Hugo, de Araujo Goncalves, Pedio, Shin, Sanghoon, Choi, Jung Hyun, Virmani, Renu, Samady, Habib, Stone, Peter H, Berman, Daniel S, Narula, Jagat, Shaw, Leslee J, Bax, Jeroen J, Chinnaiyan, Kavitha, Raff, Gilbert, Al-Mallah, Mouaz H, Lin, Fay Y, Min, James K, Sung, Ji Min, Lee, Sang-Eun, and Chang, Hyuk-Jae

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Biomedical Imaging, Heart Disease, Cardiovascular, Heart Disease - Coronary Heart Disease, Atherosclerosis, Clinical Research, Aetiology, 2.1 Biological and endogenous factors, Computed Tomography Angiography, Coronary Angiography, Coronary Artery Disease, Coronary Vessels, Disease Progression, Humans, Plaque, Atherosclerotic, Predictive Value of Tests, Risk Factors, Vascular Calcification, atherosclerosis, coronary artery calcium, coronary artery disease, coronary computed tomography angiography, statins, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

ObjectivesThe aim of the current study was to explore the impact of plaque calcification in terms of absolute calcified plaque volume (CPV) and in the context of its percentage of the total plaque volume at a lesion and patient level on the progression of coronary artery disease.BackgroundCoronary artery calcification is an established marker of risk of future cardiovascular events. Despite this, plaque calcification is also considered a marker of plaque stability, and it increases in response to medical therapy.MethodsThis analysis included 925 patients with 2,568 lesions from the PARADIGM (Progression of Atherosclerotic Plaque Determined by Computed Tomographic Angiography Imaging) registry, in which patients underwent clinically indicated serial coronary computed tomography angiography. Plaque calcification was examined by using CPV and percent CPV (PCPV), calculated as (CPV/plaque volume) × 100 at a per-plaque and per-patient level (summation of all individual plaques).ResultsCPV was strongly correlated with plaque volume (r = 0.780; p

Published
2021

16. Hydrodynamic Assessment of Explanted Degenerated Transcatheter Aortic Valves

Author

Sathananthan, Janarthanan, primary, Nigade, Anish, additional, Meier, David, additional, Navarro, Dante, additional, Spencer, Julianne, additional, Lai, Althea, additional, Gill, Hacina, additional, Pirelli, Luigi, additional, Webb, John G., additional, Wood, David A., additional, Lutter, Georg, additional, Puehler, Thomas, additional, Tang, Gilbert H.L., additional, Fukuhara, Shinichi, additional, and Sellers, Stephanie L., additional

Published
2024
Full Text
View/download PDF

17. Impact of Smoking on Coronary Volume–to–Myocardial Mass Ratio: An ADVANCE Registry Substudy

Author

Holmes, Kenneth R., primary, Gulsin, Gaurav S., additional, Fairbairn, Timothy A., additional, Hurwitz-Koweek, Lynne, additional, Matsuo, Hitoshi, additional, Nørgaard, Bjarne L., additional, Jensen, Jesper M., additional, Sand, Niels-Peter Rønnow, additional, Nieman, Koen, additional, Bax, Jeroen J., additional, Pontone, Gianluca, additional, Chinnaiyan, Kavitha M., additional, Rabbat, Mark G., additional, Amano, Tetsuya, additional, Kawasaki, Tomohiro, additional, Akasaka, Takashi, additional, Kitabata, Hironori, additional, Rogers, Campbell, additional, Patel, Manesh R., additional, Payne, Geoffrey W., additional, Leipsic, Jonathon A., additional, and Sellers, Stephanie L., additional

Published
2024
Full Text
View/download PDF

19. Natural History of Diabetic Coronary Atherosclerosis by Quantitative Measurement of Serial Coronary Computed Tomographic Angiography Results of the PARADIGM Study

Author

Kim, Ung, Leipsic, Jonathon A, Sellers, Stephanie L, Shao, Michael, Blanke, Philipp, Hadamitzky, Martin, Kim, Yong-Jin, Conte, Edoardo, Andreini, Daniele, Pontone, Gianluca, Budoff, Matthew J, Gottlieb, Ilan, Lee, Byoung Kwon, Chun, Eun Ju, Cademartiri, Filippo, Maffei, Erica, Marques, Hugo, Shin, Sanghoon, Choi, Jung Hyun, Virmani, Renu, Samady, Habib, Stone, Peter H, Berman, Daniel S, Narula, Jagat, Shaw, Leslee J, Bax, Jeroen J, Min, James K, and Chang, Hyuk-Jae

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Biomedical Imaging, Cardiovascular, Atherosclerosis, Prevention, Clinical Research, Heart Disease, Diabetes, Heart Disease - Coronary Heart Disease, Detection, screening and diagnosis, 4.2 Evaluation of markers and technologies, Aged, Computed Tomography Angiography, Coronary Angiography, Coronary Artery Disease, Diabetic Angiopathies, Female, Humans, Male, Middle Aged, Plaque, Atherosclerotic, Predictive Value of Tests, Prognosis, Registries, Retrospective Studies, Risk Assessment, Risk Factors, Sex Factors, Time Factors, computed tomography, coronary artery disease, diabetes mellitus, plaque, progression, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

ObjectivesThis study aimed to determine the rate and extent of plaque progression (PP), changes in plaque features, and clinical predictors of PP in patients with diabetes mellitus (DM).BackgroundThe natural history of coronary PP in patients with DM is not well established.MethodsA total of 1,602 patients (age 61.3 ± 9.0 years; 60.3% men; median scan interval 3.8 years) who underwent serial coronary computed tomography angiography over a period of at least 24 months were enrolled and analyzed from the PARADIGM (Progression of Atherosclerotic Plaque Determined by Computed Tomographic Angiography Imaging) trial. Study endpoints were changes in plaque features in diabetics with PP and risk factors for PP by serial coronary computed tomography angiography between patients with and without DM. PP was defined if plaque volume at follow-up minus plaque volume at baseline was >0.ResultsDM was an independent risk factor for PP (84.6%; 276 of 326 patients with PP) in multivariate analysis (odds ratio [OR]: 1.526; 95% confidence interval [CI]: 1.100 to 2.118; p = 0.011). Independent risk factors for PP in patients with DM were male sex (OR: 1.485; 95% CI: 1.003 to 2.199; p = 0.048) and mean plaque burden at baseline ≥75% (OR: 3.121; 95% CI: 1.701 to 5.725; p ≤0.001). After propensity matching, percent changes in overall plaque volume (30.3 ± 36.9% in patients without DM and 36.0 ± 29.7% in those with DM; p = 0.032) and necrotic core volume (-7.0 ± 35.8% in patients without DM and 21.5 ± 90.5% in those with DM; p = 0.007) were significantly greater in those with DM. The frequency of spotty calcification, positive remodeling, and burden of low-attenuation plaque were significantly greater in patients with DM.ConclusionsPeople with DM experience greater PP, particularly significantly greater progression in adverse plaque, than those without DM. Male sex and mean plaque burden >75% at baseline were identified as independent risk factors for PP.

Published
2018

20. Standardized Definitions for Bioprosthetic Valve Dysfunction Following Aortic or Mitral Valve Replacement: JACC State-of-the-Art Review

Author

Pibarot, Philippe, Herrmann, Howard C., Wu, Changfu, Hahn, Rebecca T., Otto, Catherine M., Abbas, Amr E., Chambers, John, Dweck, Marc R., Leipsic, Jonathon A., Simonato, Matheus, Rogers, Toby, Sathananthan, Janarthanan, Guerrero, Mayra, Ternacle, Julien, Wijeysundera, Harindra C., Sondergaard, Lars, Barbanti, Marco, Salaun, Erwan, Généreux, Philippe, Kaneko, Tsuyoshi, Landes, Uri, Wood, David A., Deeb, G. Michael, Sellers, Stephanie L., Lewis, John, Madhavan, Mahesh, Gillam, Linda, Reardon, Michael, Bleiziffer, Sabine, O’Gara, Patrick T., Rodés-Cabau, Josep, Grayburn, Paul A., Lancellotti, Patrizio, Thourani, Vinod H., Bax, Jeroen J., Mack, Michael J., and Leon, Martin B.

Published
2022
Full Text
View/download PDF

21. 18F-Sodium Fluoride Positron Emission Tomography and Computed Tomography in Acute Aortic Syndrome

Author

Syed, Maaz B.J., Fletcher, Alexander J., Debono, Samuel, Forsythe, Rachel O., Williams, Michelle C., Dweck, Marc R., Shah, Anoop S.V., Macaskill, Mark G., Tavares, Adriana, Denvir, Martin A., Lim, Kelvin, Wallace, William A., Kaczynski, Jakub, Clark, Tim, Sellers, Stephanie L., Masson, Neil, Falah, Orwa, Chalmers, Roderick T.A., Tambyraja, Andrew L., van Beek, Edwin J.R., and Newby, David E.

Published
2022
Full Text
View/download PDF

23. Relationship Between Coronary Artery Calcium and Atherosclerosis Progression Among Patients With Suspected Coronary Artery Disease

Author

Hollenberg, Emma J., Lin, Fay, Blaha, Michael J., Budoff, Matthew J., van den Hoogen, Inge J., Gianni, Umberto, Lu, Yao, Bax, A. Maxim, van Rosendael, Alexander R., Tantawy, Sara W., Andreini, Daniele, Cademartiri, Filippo, Chinnaiyan, Kavitha, Choi, Jung Hyun, Conte, Edoardo, de Araújo Gonçalves, Pedro, Hadamitzky, Martin, Maffei, Erica, Pontone, Gianluca, Shin, Sanghoon, Kim, Yong-Jin, Lee, Byoung Kwon, Chun, Eun Ju, Sung, Ji Min, Gimelli, Alessia, Lee, Sang-Eun, Bax, Jeroen J., Berman, Daniel S., Sellers, Stephanie L., Leipsic, Jonathon A., Blankstein, Ron, Narula, Jagat, Chang, Hyuk-Jae, and Shaw, Leslee J.

Published
2022
Full Text
View/download PDF

24. 18F-GP1 Positron Emission Tomography and Bioprosthetic Aortic Valve Thrombus

Author

Bing, Rong, Deutsch, Marcus-André, Sellers, Stephanie L., Corral, Carlos Alcaide, Andrews, Jack P.M., van Beek, Edwin J.R., Bleiziffer, Sabine, Burchert, Wolfgang, Clark, Tim, Dey, Damini, Friedrichs, Kai, Gummert, Jan F., Koglin, Norman, Leipsic, Jonathon A., Lindner, Oliver, MacAskill, Mark G., Milting, Hendrik, Pessotto, Renzo, Preuss, Rainer, Raftis, Jennifer B., Rudolph, Tanja K., Rudolph, Volker, Slomka, Piotr, Stephens, Andrew W., Tavares, Adriana, Tzolos, Evangelos, Weir, Nick, White, Audrey C., Williams, Michelle C., Zabel, Reinhard, Dweck, Marc R., Hugenberg, Verena, and Newby, David E.

Published
2022
Full Text
View/download PDF

27. Impact of Non-obstructive left main disease on the progression of coronary artery disease: A PARADIGM substudy.

Author

Weir-McCall, Jonathan R, Blanke, Philipp, Sellers, Stephanie L, Ahmadi, Amir A, Andreini, Daniele, Budoff, Matthew J, Cademartiri, Filippo, Chinnaiyan, Kavitha, Choi, Jung Hyun, Chun, Eun Ju, Conte, Edoardo, Gottlieb, Ilan, Hadamitzky, Martin, Kim, Yong Jin, Lee, Byoung Kwon, Lee, Sang-Eun, Maffei, Erica, Marques, Hugo, Pontone, Gianluca, Raff, Gilbert L, Shin, Sanghoon, Sung, Ji Min, Stone, Peter, Samady, Habib, Virmani, Renu, Narula, Jagat, Berman, Daniel S, Shaw, Leslee J, Bax, Jeroen J, Lin, Fay Y, Min, James K, Chang, Hyuk-Jae, and Leipsic, Jonathon A

Subjects
Coronary Vessels, Humans, Coronary Stenosis, Disease Progression, Fibrosis, Necrosis, Coronary Angiography, Severity of Illness Index, Registries, Prevalence, Multivariate Analysis, Linear Models, Risk Assessment, Risk Factors, Chi-Square Distribution, Predictive Value of Tests, Time Factors, Aged, Middle Aged, Female, Male, Coronary Artery Disease, Plaque, Atherosclerotic, Vascular Calcification, Computed Tomography Angiography, Coronary computed tomography angiography, Left main coronary artery disease, Natural history, Cardiovascular System & Hematology, Clinical Sciences, Cardiorespiratory Medicine and Haematology
Abstract

BACKGROUND:The aim of the study is examine the impact of non-obstructive (

Published
2018

29. Tricuspid Regurgitation and TAVR: Outcomes, Risk Factors and Biomarkers

Author

Puehler, Thomas, primary, Pommert, Nina Sophie, additional, Freitag-Wolf, Sandra, additional, Seoudy, Hatim, additional, Ernst, Markus, additional, Haneya, Assad, additional, Sathananthan, Janarthanan, additional, Sellers, Stephanie L., additional, Meier, David, additional, Schöttler, Jan, additional, Müller, Oliver J., additional, Salehi Ravesh, Mona, additional, Saad, Mohammed, additional, Frank, Derk, additional, and Lutter, Georg, additional

Published
2024
Full Text
View/download PDF

30. Redo-TAVI with the ACURATE neo2 and Prime XL for balloon-expandable transcatheter heart valve failure

Author

Meier, David, primary, Grant, Daire, additional, Frawley, Chris, additional, Akodad, Mariama, additional, Landes, Uri, additional, Kokhar, Arif A., additional, Dudek, Dariusz, additional, George, Isaac, additional, Rinaldi, Michael J., additional, Kim, Won-Keun, additional, Yakubov, Steven J., additional, Sorajja, Paul, additional, Tarantini, Giuseppe, additional, Wood, David A., additional, Webb, John G., additional, Sellers, Stephanie L., additional, and Sathananthan, Janarthanan, additional

Published
2024
Full Text
View/download PDF

31. Transcatheter Mitral Valve-in-Valve Replacement in the Presence of Pannus

Author

Jelisejevas, Julius, primary, Husain, Ali, additional, Dundas, James, additional, Chiang, Brian, additional, Akodad, Mariama, additional, Zaky, Fady, additional, Sathananthan, Gnalini, additional, Wood, David A., additional, Leipsic, Jonathon A., additional, Blanke, Philipp, additional, Sathananthan, Janarthanan, additional, Sellers, Stephanie L., additional, Meier, David, additional, and Webb, John G., additional

Published
2024
Full Text
View/download PDF

32. Abstract 10740: Effects of Renin-Angiotensin-Aldosterone-System Inhibitors on Coronary Atherosclerotic Plaques: Results From the Paradigm Registry

Author

Williams, Curtis, Han, Donghee, Takagi, Hidenobu, Fordyce, Christopher, Sellers, Stephanie, Blanke, Philipp, Lin, Fay Y, Al-Mallah, Mouaz H, Budoff, Matthew J, Cademartiri, Prof. Dr. Filippo, Chinnaiyan, Kavitha M, Conte, Edoardo, Marques, Hugo, Gottlieb, Ilan, Hadamitzky, Martin, Shin, Sanghoon, Lee, Byoung Kwon, Virmani, Renu, Samady, Habib, Choi, Jung Hyun, Berman, Daniel, Narula, Jagat, Bax, Jeroen J, Leipsic, Jonathon, and Chang, Hyuk-Jae

Published
2022
Full Text
View/download PDF

35. Comparison of Coronary Atherosclerotic Plaque Progression in East Asians and Caucasians by Serial Coronary Computed Tomographic Angiography:A PARADIGM Substudy

Author

Ben Zekry, Sagit, Sreedharan, Subhashaan, Han, Donghee, Sellers, Stephanie, Ahmadi, Amir A., Blanke, Philipp, Hadamitzky, Martin, Kim, Yong-Jin, Conte, Edoardo, Andreini, Daniele, Pontone, Gianluca, Budoff, Matthew J., Gottlieb, Ilan, Lee, Byoung Kwon, Chun, Eun Ju, Cademartiri, Filippo, Maffei, Erica, Marques, Hugo, Shin, Sanghoon, Choi, Jung Hyun, Virmani, Renu, Samady, Habib, Stone, Peter H., Berman, Daniel S., Narula, Jagat, Shaw, Leslee J., Bax, Jeroen J., Leipsic, Jonathon, and Chang, Hyuk-Jae

Published
2021
Full Text
View/download PDF

38. Optimization of Enzymatic and Chemical Decellularization of Native Porcine Heart Valves for the Generation of Decellularized Xenografts.

Author

Saeid Nia, Monireh, Floder, Lena Maria, Seiler, Jette Anika, Puehler, Thomas, Pommert, Nina Sophie, Berndt, Rouven, Meier, David, Sellers, Stephanie L., Sathananthan, Janarthanan, Zhang, Xiling, Hasler, Mario, Gorb, Stanislav N., Warnecke, Gregor, and Lutter, Georg

Subjects
HEART valves, XENOGRAFTS, HEART valve diseases, TRITON X-100, IMMUNE response, TISSUE engineering
Abstract

One of the most important medical interventions for individuals with heart valvular disease is heart valve replacement, which is not without substantial challenges, particularly for pediatric patients. Due to their biological properties and biocompatibility, natural tissue-originated scaffolds derived from human or animal sources are one type of scaffold that is widely used in tissue engineering. However, they are known for their high potential for immunogenicity. Being free of cells and genetic material, decellularized xenografts, consequently, have low immunogenicity and, thus, are expected to be tolerated by the recipient's immune system. The scaffold ultrastructure and ECM composition can be affected by cell removal agents. Therefore, applying an appropriate method that preserves intact the structure of the ECM plays a critical role in the final result. So far, there has not been an effective decellularization technique that preserves the integrity of the heart valve's ultrastructure while securing the least amount of genetic material left. This study demonstrates a new protocol with untraceable cells and residual DNA, thereby maximally reducing any chance of immunogenicity. The mechanical and biochemical properties of the ECM resemble those of native heart valves. Results from this study strongly indicate that different critical factors, such as ionic detergent omission, the substitution of Triton X-100 with Tergitol, and using a lower concentration of trypsin and a higher concentration of DNase and RNase, play a significant role in maintaining intact the ultrastructure and function of the ECM. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

46. Producing and Testing Prototype Tissue-Engineered 3D Tri-Leaflet Valved Stents on Biodegradable Poly-ε-Caprolactone Scaffolds

Author

Lutter, Georg, primary, Pommert, Nina Sophie, additional, Zhang, Xiling, additional, Seiler, Jette, additional, Saeid Nia, Monireh, additional, Meier, David, additional, Sellers, Stephanie L., additional, Gorb, Stanislav N., additional, Hansen, Jan-Hinnerk, additional, Seoudy, Hatim, additional, Müller, Oliver J., additional, Saad, Mohammed, additional, Haneya, Assad, additional, Frank, Derk, additional, Puehler, Thomas, additional, and Sathananthan, Janarthanan, additional

Published
2023
Full Text
View/download PDF

47. Artificial Intelligence–based Coronary Stenosis Quantification at Coronary CT Angiography versus Quantitative Coronary Angiography

Author

Dundas, James, primary, Leipsic, Jonathon A., additional, Sellers, Stephanie, additional, Blanke, Philipp, additional, Miranda, Patricia, additional, Ng, Nicholas, additional, Mullen, Sarah, additional, Meier, David, additional, Akodad, Mariama, additional, Sathananthan, Janarthanan, additional, Collet, Carlos, additional, de Bruyne, Bernard, additional, Muller, Olivier, additional, and Tzimas, Georgios, additional

Published
2023
Full Text
View/download PDF

48. Redo-TAVI with SAPIEN 3 in SAPIEN XT or SAPIEN 3 &ndash; impact of pre- and post-dilatation on final THV expansion

Author

Meier, David, primary, Landes, Uri, additional, Sondergaard, Lars, additional, De Backer, Ole, additional, Lutter, Georg, additional, Puehler, Thomas, additional, Akodad, Mariama, additional, Tzimas, Georgios, additional, Blanke, Philipp, additional, Payne, Geoffrey W., additional, Lai, Althea, additional, Gill, Hacina, additional, Wood, David A., additional, Webb, John G., additional, Sellers, Stephanie L., additional, and Sathananthan, Janarthanan, additional

Published
2023
Full Text
View/download PDF

49. Increased Classical Monocytes in South Asian Compared With White Caucasian Individuals at Risk for Coronary Atherosclerosis

Author

Hosseini, Farshad, primary, Franco, Christopher, additional, Whalen, Beth A., additional, Taylor, Carolyn M., additional, Sellers, Stephanie L., additional, Khan, Nadia, additional, Kaila, Kendeep, additional, Bainey, Kevin, additional, Farkouh, Michael, additional, Gupta, Milan, additional, Verma, Subodh, additional, and Ramanathan, Krishnan, additional

Published
2023
Full Text
View/download PDF

50. Transcatheter Mitral Valve Replacement

Author

Husain, Ali, primary, Meier, David, additional, Dundas, James, additional, Akodad, Mariama, additional, Jelisejevas, Julius, additional, Zaky, Fady, additional, Moss, Robert, additional, Sathananthan, Gnalini, additional, Sellers, Stephanie L., additional, Leipsic, Jonathon A., additional, Blanke, Philipp, additional, Wood, David A., additional, Sathananthan, Janarthanan, additional, Boone, Robert, additional, and Webb, John G., additional

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results