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2. The ChoCO-W prospective observational global study: Does COVID-19 increase gangrenous cholecystitis?

Author

De Simone, Belinda, Abu-Zidan, Fikri M., Chouillard, Elie, Di Saverio, Salomone, Sartelli, Massimo, Podda, Mauro, Gomes, Carlos Augusto, Moore, Ernest E., Moug, Susan J., Ansaloni, Luca, Kluger, Yoram, Coccolini, Federico, Landaluce-Olavarria, Aitor, Estraviz-Mateos, Begoña, Uriguen-Etxeberria, Ana, Giordano, Alessio, Luna, Alfonso Palmieri, Amín, Luz Adriana Hernández, Hernández, Adriana María Palmieri, Shabana, Amanda, Dzulkarnaen, Zakaria Andee, Othman, Muhammad Asyraf, Sani, Mohamad Ikhwan, Balla, Andrea, Scaramuzzo, Rosa, Lepiane, Pasquale, Bottari, Andrea, Staderini, Fabio, Cianchi, Fabio, Cavallaro, Andrea, Zanghì, Antonio, Cappellani, Alessandro, Campagnacci, Roberto, Maurizi, Angela, Martinotti, Mario, Ruggieri, Annamaria, Jusoh, Asri Che, Rahman, Karim Abdul, Zulkifli, Anis Suraya M., Petronio, Barbara, Matías-García, Belén, Quiroga-Valcárcel, Ana, Mendoza-Moreno, Fernando, Atanasov, Boyko, Campanile, Fabio Cesare, Vecchioni, Ilaria, Cardinali, Luca, Travaglini, Grazia, Sebastiani, Elisa, Chooklin, Serge, Chuklin, Serhii, Cianci, Pasquale, Restini, Enrico, Capuzzolo, Sabino, Currò, Giuseppe, Filippo, Rosalinda, Rispoli, Michele, Aparicio-Sánchez, Daniel, Muñóz-Cruzado, Virginia Durán, Barbeito, Sandra Dios, Delibegovic, Samir, Kesetovic, Amar, Sasia, Diego, Borghi, Felice, Giraudo, Giorgio, Visconti, Diego, Doria, Emanuele, Santarelli, Mauro, Luppi, Davide, Bonilauri, Stefano, Grossi, Ugo, Zanus, Giacomo, Sartori, Alberto, Piatto, Giacomo, De Luca, Maurizio, Vita, Domenico, Conti, Luigi, Capelli, Patrizio, Cattaneo, Gaetano Maria, Marinis, Athanasios, Vederaki, Styliani-Aikaterini, Bayrak, Mehmet, Altıntas, Yasemin, Uzunoglu, Mustafa Yener, Demirbas, Iskender Eren, Altinel, Yuksel, Meric, Serhat, Aktimur, Yunus Emre, Uymaz, Derya Salim, Omarov, Nail, Azamat, Ibrahim, Lostoridis, Eftychios, Nagorni, Eleni-Aikaterini, Pujante, Antonio, Anania, Gabriele, Bombardini, Cristina, Bagolini, Francesco, Gonullu, Emre, Mantoglu, Baris, Capoglu, Recayi, Cappato, Stefano, Muzio, Elena, Colak, Elif, Polat, Suleyman, Koylu, Zehra Alan, Altintoprak, Fatih, Bayhan, Zülfü, Akin, Emrah, Andolfi, Enrico, Rezart, Sulce, Kim, Jae Il, Jung, Sung Won, Shin, Yong Chan, Enciu, Octavian, Toma, Elena Adelina, Medas, Fabio, Canu, Gian Luigi, Cappellacci, Federico, D’Acapito, Fabrizio, Ercolani, Giorgio, Solaini, Leonardo, Roscio, Francesco, Clerici, Federico, Gelmini, Roberta, Serra, Francesco, Rossi, Elena Giulia, Fleres, Francesco, Clarizia, Guglielmo, Spolini, Alessandro, Ferrara, Francesco, Nita, Gabriela, Sarnari, Jlenia, Gachabayov, Mahir, Abdullaev, Abakar, Poillucci, Gaetano, Palini, Gian Marco, Veneroni, Simone, Garulli, Gianluca, Piccoli, Micaela, Pattacini, Gianmaria Casoni, Pecchini, Francesca, Argenio, Giulio, Armellino, Mariano Fortunato, Brisinda, Giuseppe, Tedesco, Silvia, Fransvea, Pietro, Ietto, Giuseppe, Franchi, Caterina, Carcano, Giulio, Martines, Gennaro, Trigiante, Giuseppe, Negro, Giulia, Vega, Gustavo Machain, González, Agustín Rodríguez, Ojeda, Leonardo, Piccolo, Gaetano, Bondurri, Andrea, Maffioli, Anna, Guerci, Claudio, Sin, Boo Han, Zuhdi, Zamri, Azman, Azlanudin, Mousa, Hussam, al Bahri, Shadi, Augustin, Goran, Romic, Ivan, Moric, Trpimir, Nikolopoulos, Ioannis, Andreuccetti, Jacopo, Pignata, Giusto, D’Alessio, Rossella, Kenig, Jakub, Skorus, Urszula, Fraga, Gustavo Pereira, Hirano, Elcio Shiyoiti, de Lima Bertuol, Jackson Vinícius, Isik, Arda, Kurnaz, Eray, Asghar, Mohammad Sohail, Afzal, Ameer, Akbar, Ali, Nikolouzakis, Taxiarchis Konstantinos, Lasithiotakis, Konstantinos, Chrysos, Emmanuel, Das, Koray, Özer, Nazmi, Seker, Ahmet, Ibrahim, Mohamed, Hamid, Hytham K. S., Babiker, Ahmed, Bouliaris, Konstantinos, Koukoulis, George, Kolla, Chrysoula-Christina, Lucchi, Andrea, Agostinelli, Laura, Taddei, Antonio, Fortuna, Laura, Agostini, Carlotta, Licari, Leo, Viola, Simona, Callari, Cosimo, Laface, Letizia, Abate, Emmanuele, Casati, Massimiliano, Anastasi, Alessandro, Canonico, Giuseppe, Gabellini, Linda, Tosi, Lorenzo, Guariniello, Anna, Zanzi, Federico, Bains, Lovenish, Sydorchuk, Larysa, Iftoda, Oksana, Sydorchuk, Andrii, Malerba, Michele, Costanzo, Federico, Galleano, Raffaele, Monteleone, Michela, Costanzi, Andrea, Riva, Carlo, Walędziak, Maciej, Kwiatkowski, Andrzej, Czyżykowski, Łukasz, Major, Piotr, Strzałka, Marcin, Matyja, Maciej, Natkaniec, Michal, Valenti, Maria Rosaria, Di Vita, Maria Domenica Pia, Sotiropoulou, Maria, Kapiris, Stylianos, Massalou, Damien, Veroux, Massimiliano, Volpicelli, Alessio, Gioco, Rossella, Uccelli, Matteo, Bonaldi, Marta, Olmi, Stefano, Nardi, Matteo, Livadoti, Giada, Mesina, Cristian, Dumitrescu, Theodor Viorel, Ciorbagiu, Mihai Calin, Ammendola, Michele, Ammerata, Giorgio, Romano, Roberto, Slavchev, Mihail, Misiakos, Evangelos P., Pikoulis, Emmanouil, Papaconstantinou, Dimitrios, Elbahnasawy, Mohamed, Abdel-elsalam, Sherief, Felsenreich, Daniel M., Jedamzik, Julia, Michalopoulos, Nikolaos V., Sidiropoulos, Theodoros A., Papadoliopoulou, Maria, Cillara, Nicola, Deserra, Antonello, Cannavera, Alessandro, Negoi, Ionuţ, Schizas, Dimitrios, Syllaios, Athanasios, Vagios, Ilias, Gourgiotis, Stavros, Dai, Nick, Gurung, Rekha, Norrey, Marcus, Pesce, Antonio, Feo, Carlo Vittorio, Fabbri, Nicolo’, Machairas, Nikolaos, Dorovinis, Panagiotis, Keramida, Myrto D., Mulita, Francesk, Verras, Georgios Ioannis, Vailas, Michail, Yalkin, Omer, Iflazoglu, Nidal, Yigit, Direnc, Baraket, Oussama, Ayed, Karim, Ghalloussi, Mohamed hedi, Patias, Parmenion, Ntokos, Georgios, Rahim, Razrim, Bala, Miklosh, Kedar, Asaf, Sawyer, Robert G., Trinh, Anna, Miller, Kelsey, Sydorchuk, Ruslan, Knut, Ruslan, Plehutsa, Oleksandr, Liman, Rumeysa Kevser, Ozkan, Zeynep, Kader, Saleh Abdel, Gupta, Sanjay, Gureh, Monika, Saeidi, Sara, Aliakbarian, Mohsen, Dalili, Amin, Shoko, Tomohisa, Kojima, Mitsuaki, Nakamoto, Raira, Atici, Semra Demirli, Tuncer, Gizem Kilinc, Kaya, Tayfun, Delis, Spiros G., Rossi, Stefano, Picardi, Biagio, del Monte, Simone Rossi, Triantafyllou, Tania, Theodorou, Dimitrios, Pintar, Tadeja, Salobir, Jure, Manatakis, Dimitrios K., Tasis, Nikolaos, Acheimastos, Vasileios, Ioannidis, Orestis, Loutzidou, Lydia, Symeonidis, Savvas, de Sá, Tiago Correia, Rocha, Mónica, Guagni, Tommaso, Pantalone, Desiré, Maltinti, Gherardo, Khokha, Vladimir, Abdel-elsalam, Wafaa, Ghoneim, Basma, López-Ruiz, José Antonio, Kara, Yasin, Zainudin, Syaza, Hayati, Firdaus, Azizan, Nornazirah, Khei, Victoria Tan Phooi, Yi, Rebecca Choy Xin, Sellappan, Harivinthan, Demetrashvili, Zaza, Lekiashvili, Nika, Tvaladze, Ana, Froiio, Caterina, Bernardi, Daniele, Bonavina, Luigi, Gil-Olarte, Angeles, Grassia, Sebastiano, Romero-Vargas, Estela, Bianco, Francesco, Gumbs, Andrew A., Dogjani, Agron, Agresta, Ferdinando, Litvin, Andrey, Balogh, Zsolt J., Gendrikson, George, Martino, Costanza, Damaskos, Dimitrios, Pararas, Nikolaos, Kirkpatrick, Andrew, Kurtenkov, Mikhail, Gomes, Felipe Couto, Pisanu, Adolfo, Nardello, Oreste, Gambarini, Fabrizio, Aref, Hager, Angelis, Nicola de’, Agnoletti, Vanni, Biondi, Antonio, Vacante, Marco, Griggio, Giulia, Tutino, Roberta, Massani, Marco, Bisetto, Giovanni, Occhionorelli, Savino, Andreotti, Dario, Lacavalla, Domenico, Biffl, Walter L., and Catena, Fausto

Published
2022
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3. Synchronous early rectal adenocarcinoma and neuroendocrine tumour: A treatment strategy.

Author

Alagoo, Dinesh, Sellappan, Harivinthan, Rajanthran, Saravana Kumar, Azizan, Nornazirah, Johari, Nur Farehah, Zakaria, Andee Dzulkarnaen, and Hayati, Firdaus

Subjects
*NEUROENDOCRINE tumors, *COLON cancer, *MIDDLE-aged women, *GENETIC markers, *COLORECTAL cancer
Abstract

Introduction: Synchronous colorectal adenocarcinoma with neuroendocrine tumour (NET) are a unique combination of tumours. These may be incidental lesions, usually a histopathological diagnosis rather than a clinical diagnosis from symptoms, examination or even gross appearances. Aim: This paper aims to highlight our management strategy on manging a middle-aged woman with synchronous rectal adenocarcinoma and NET. Case study: A 53-year-old woman presented with lower gastrointestinal bleeding with constitutional symptoms. Clinical examination and colonoscopy revealed a classical rectal adenocarcinoma, confirmed via biopsy. However, the final histopathology reports of the resected tumour revealed an early rectal adenocarcinoma with synchronous NET. Results and discussion: We review the relevant literature and a discussion regarding guidelines available for diagnosis, follow-up and surveillance of this rare case. Conclusions: There are no current guidelines for surveillance colonoscopy after detecting gastrointestinal NET, particularly synchronous tumours. NET may be another colorectal cancer risk factor with similar mutations and common genetic markers. Clinicians should consider doing a colonoscopy when or if their patients are diagnosed with any gastrointestinal NET. Detection of any NET warrants a thorough evaluation of the whole colon for colorectal cancer and close surveillance so that timely management can be achieved. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Gastric duplication cyst with a red flag presentation: a case report

Author

Alagoo, Dinesh, Sellappan, Harivinthan, Jayasilan, Jayaprihyan, Azizan, Nornazirah, and Hayati, Firdaus

Subjects
Duplication cysts, hypergastrinaemia, parasitic diseases, gastrointestinal bleeding, case report, population characteristics, human activities
Abstract

Gastric duplication cyst (GDC) is a rare congenital malformation of the gastrointestinal (GI) tract. Despite being benign in the entity, its complications vary from an asymptomatic abdominal mass to fulminant or massive GI bleeding. A 28-year-old lady presented with unexplained GI haemorrhage, in which the upper endoscopy showed a classic feature of GI stromal tumour. The preoperative diagnosis was also confirmed by the computed tomography. She subsequently underwent surgical resection and the final histopathology was consistent with a benign entity of GDC.

Published
2021

11. Malignant Subcutaneous Perivascular Epithelioid Cell Tumor of Anterior Abdominal Wall.

Author

Eng Yeow Gan, David, Xin Yi Choy, Rebecca, Sellappan, Harivinthan, Hayati, Firdaus, and Azizan, Nornazirah

Subjects
*ABDOMEN, *HISTOLOGY, *EPITHELIAL cells, CONNECTIVE tissue tumors
Abstract

Perivascular epithelioid cell tumors (PEComas) are a family of rare mesenchymal tumors with discrete histological and immunohistochemical characteristics. Even rarer among them are cutaneous and subcutaneous PEComas. We describe a 34-year-old woman who presented with a large anterior abdominal subcutaneous lesion showing intact overlying skin and no obvious invasion of the abdominal musculature. A wide local excision was performed. Histopathology revealed a solitary tumor measuring 75 x 55 x 90 mm with epithelioid cells in nests with thin fibrovascular septa and spindle cells. Resection margins were clear with no invasion to the skin or rectus sheath. Tumor cells were positive for HMB-45 but negative for other markers. This is the largest subcutaneous PEComa reported to date. [ABSTRACT FROM AUTHOR]

Published
2021
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12. The ChoCO-W prospective observational global study: Does COVID-19 increase gangrenous cholecystitis?

Author

Belinda De Simone, Fikri M. Abu-Zidan, Elie Chouillard, Salomone Di Saverio, Massimo Sartelli, Mauro Podda, Carlos Augusto Gomes, Ernest E. Moore, Susan J. Moug, Luca Ansaloni, Yoram Kluger, Federico Coccolini, Aitor Landaluce-Olavarria, Begoña Estraviz-Mateos, Ana Uriguen-Etxeberria, Alessio Giordano, Alfonso Palmieri Luna, Luz Adriana Hernández Amín, Adriana María Palmieri Hernández, Amanda Shabana, Zakaria Andee Dzulkarnaen, Muhammad Asyraf Othman, Mohamad Ikhwan Sani, Andrea Balla, Rosa Scaramuzzo, Pasquale Lepiane, Andrea Bottari, Fabio Staderini, Fabio Cianchi, Andrea Cavallaro, Antonio Zanghì, Alessandro Cappellani, Roberto Campagnacci, Angela Maurizi, Mario Martinotti, Annamaria Ruggieri, Asri Che Jusoh, Karim Abdul Rahman, Anis Suraya M. Zulkifli, Barbara Petronio, Belén Matías-García, Ana Quiroga-Valcárcel, Fernando Mendoza-Moreno, Boyko Atanasov, Fabio Cesare Campanile, Ilaria Vecchioni, Luca Cardinali, Grazia Travaglini, Elisa Sebastiani, Serge Chooklin, Serhii Chuklin, Pasquale Cianci, Enrico Restini, Sabino Capuzzolo, Giuseppe Currò, Rosalinda Filippo, Michele Rispoli, Daniel Aparicio-Sánchez, Virginia Durán Muñóz-Cruzado, Sandra Dios Barbeito, Samir Delibegovic, Amar Kesetovic, Diego Sasia, Felice Borghi, Giorgio Giraudo, Diego Visconti, Emanuele Doria, Mauro Santarelli, Davide Luppi, Stefano Bonilauri, Ugo Grossi, Giacomo Zanus, Alberto Sartori, Giacomo Piatto, Maurizio De Luca, Domenico Vita, Luigi Conti, Patrizio Capelli, Gaetano Maria Cattaneo, Athanasios Marinis, Styliani-Aikaterini Vederaki, Mehmet Bayrak, Yasemin Altıntas, Mustafa Yener Uzunoglu, Iskender Eren Demirbas, Yuksel Altinel, Serhat Meric, Yunus Emre Aktimur, Derya Salim Uymaz, Nail Omarov, Ibrahim Azamat, Eftychios Lostoridis, Eleni-Aikaterini Nagorni, Antonio Pujante, Gabriele Anania, Cristina Bombardini, Francesco Bagolini, Emre Gonullu, Baris Mantoglu, Recayi Capoglu, Stefano Cappato, Elena Muzio, Elif Colak, Suleyman Polat, Zehra Alan Koylu, Fatih Altintoprak, Zülfü Bayhan, Emrah Akin, Enrico Andolfi, Sulce Rezart, Jae Il Kim, Sung Won Jung, Yong Chan Shin, Octavian Enciu, Elena Adelina Toma, Fabio Medas, Gian Luigi Canu, Federico Cappellacci, Fabrizio D’Acapito, Giorgio Ercolani, Leonardo Solaini, Francesco Roscio, Federico Clerici, Roberta Gelmini, Francesco Serra, Elena Giulia Rossi, Francesco Fleres, Guglielmo Clarizia, Alessandro Spolini, Francesco Ferrara, Gabriela Nita, Jlenia Sarnari, Mahir Gachabayov, Abakar Abdullaev, Gaetano Poillucci, Gian Marco Palini, Simone Veneroni, Gianluca Garulli, Micaela Piccoli, Gianmaria Casoni Pattacini, Francesca Pecchini, Giulio Argenio, Mariano Fortunato Armellino, Giuseppe Brisinda, Silvia Tedesco, Pietro Fransvea, Giuseppe Ietto, Caterina Franchi, Giulio Carcano, Gennaro Martines, Giuseppe Trigiante, Giulia Negro, Gustavo Machain Vega, Agustín Rodríguez González, Leonardo Ojeda, Gaetano Piccolo, Andrea Bondurri, Anna Maffioli, Claudio Guerci, Boo Han Sin, Zamri Zuhdi, Azlanudin Azman, Hussam Mousa, Shadi al Bahri, Goran Augustin, Ivan Romic, Trpimir Moric, Ioannis Nikolopoulos, Jacopo Andreuccetti, Giusto Pignata, Rossella D’Alessio, Jakub Kenig, Urszula Skorus, Gustavo Pereira Fraga, Elcio Shiyoiti Hirano, Jackson Vinícius de Lima Bertuol, Arda Isik, Eray Kurnaz, Mohammad Sohail Asghar, Ameer Afzal, Ali Akbar, Taxiarchis Konstantinos Nikolouzakis, Konstantinos Lasithiotakis, Emmanuel Chrysos, Koray Das, Nazmi Özer, Ahmet Seker, Mohamed Ibrahim, Hytham K. S. Hamid, Ahmed Babiker, Konstantinos Bouliaris, George Koukoulis, Chrysoula-Christina Kolla, Andrea Lucchi, Laura Agostinelli, Antonio Taddei, Laura Fortuna, Carlotta Agostini, Leo Licari, Simona Viola, Cosimo Callari, Letizia Laface, Emmanuele Abate, Massimiliano Casati, Alessandro Anastasi, Giuseppe Canonico, Linda Gabellini, Lorenzo Tosi, Anna Guariniello, Federico Zanzi, Lovenish Bains, Larysa Sydorchuk, Oksana Iftoda, Andrii Sydorchuk, Michele Malerba, Federico Costanzo, Raffaele Galleano, Michela Monteleone, Andrea Costanzi, Carlo Riva, Maciej Walędziak, Andrzej Kwiatkowski, Łukasz Czyżykowski, Piotr Major, Marcin Strzałka, Maciej Matyja, Michal Natkaniec, Maria Rosaria Valenti, Maria Domenica Pia Di Vita, Maria Sotiropoulou, Stylianos Kapiris, Damien Massalou, Massimiliano Veroux, Alessio Volpicelli, Rossella Gioco, Matteo Uccelli, Marta Bonaldi, Stefano Olmi, Matteo Nardi, Giada Livadoti, Cristian Mesina, Theodor Viorel Dumitrescu, Mihai Calin Ciorbagiu, Michele Ammendola, Giorgio Ammerata, Roberto Romano, Mihail Slavchev, Evangelos P. Misiakos, Emmanouil Pikoulis, Dimitrios Papaconstantinou, Mohamed Elbahnasawy, Sherief Abdel-elsalam, Daniel M. Felsenreich, Julia Jedamzik, Nikolaos V. Michalopoulos, Theodoros A. Sidiropoulos, Maria Papadoliopoulou, Nicola Cillara, Antonello Deserra, Alessandro Cannavera, Ionuţ Negoi, Dimitrios Schizas, Athanasios Syllaios, Ilias Vagios, Stavros Gourgiotis, Nick Dai, Rekha Gurung, Marcus Norrey, Antonio Pesce, Carlo Vittorio Feo, Nicolo’ Fabbri, Nikolaos Machairas, Panagiotis Dorovinis, Myrto D. Keramida, Francesk Mulita, Georgios Ioannis Verras, Michail Vailas, Omer Yalkin, Nidal Iflazoglu, Direnc Yigit, Oussama Baraket, Karim Ayed, Mohamed hedi Ghalloussi, Parmenion Patias, Georgios Ntokos, Razrim Rahim, Miklosh Bala, Asaf Kedar, Robert G. Sawyer, Anna Trinh, Kelsey Miller, Ruslan Sydorchuk, Ruslan Knut, Oleksandr Plehutsa, Rumeysa Kevser Liman, Zeynep Ozkan, Saleh Abdel Kader, Sanjay Gupta, Monika Gureh, Sara Saeidi, Mohsen Aliakbarian, Amin Dalili, Tomohisa Shoko, Mitsuaki Kojima, Raira Nakamoto, Semra Demirli Atici, Gizem Kilinc Tuncer, Tayfun Kaya, Spiros G. Delis, Stefano Rossi, Biagio Picardi, Simone Rossi del Monte, Tania Triantafyllou, Dimitrios Theodorou, Tadeja Pintar, Jure Salobir, Dimitrios K. Manatakis, Nikolaos Tasis, Vasileios Acheimastos, Orestis Ioannidis, Lydia Loutzidou, Savvas Symeonidis, Tiago Correia de Sá, Mónica Rocha, Tommaso Guagni, Desiré Pantalone, Gherardo Maltinti, Vladimir Khokha, Wafaa Abdel-elsalam, Basma Ghoneim, José Antonio López-Ruiz, Yasin Kara, Syaza Zainudin, Firdaus Hayati, Nornazirah Azizan, Victoria Tan Phooi Khei, Rebecca Choy Xin Yi, Harivinthan Sellappan, Zaza Demetrashvili, Nika Lekiashvili, Ana Tvaladze, Caterina Froiio, Daniele Bernardi, Luigi Bonavina, Angeles Gil-Olarte, Sebastiano Grassia, Estela Romero-Vargas, Francesco Bianco, Andrew A. Gumbs, Agron Dogjani, Ferdinando Agresta, Andrey Litvin, Zsolt J. Balogh, George Gendrikson, Costanza Martino, Dimitrios Damaskos, Nikolaos Pararas, Andrew Kirkpatrick, Mikhail Kurtenkov, Felipe Couto Gomes, Adolfo Pisanu, Oreste Nardello, Fabrizio Gambarini, Hager Aref, Nicola de’ Angelis, Vanni Agnoletti, Antonio Biondi, Marco Vacante, Giulia Griggio, Roberta Tutino, Marco Massani, Giovanni Bisetto, Savino Occhionorelli, Dario Andreotti, Domenico Lacavalla, Walter L. Biffl, Fausto Catena, De Simone, Belinda, Abu-Zidan, Fikri M, Chouillard, Elie, Di Saverio, Salomone, Sartelli, Massimo, Podda, Mauro, Gomes, Carlos Augusto, Moore, Ernest E, Moug, Susan J, Ansaloni, Luca, Kluger, Yoram, Coccolini, Federico, Landaluce-Olavarria, Aitor, Estraviz-Mateos, Begoña, Uriguen-Etxeberria, Ana, Giordano, Alessio, Luna, Alfonso Palmieri, Amín, Luz Adriana Hernández, Hernández, Adriana María Palmieri, Shabana, Amanda, Dzulkarnaen, Zakaria Andee, Othman, Muhammad Asyraf, Sani, Mohamad Ikhwan, Balla, Andrea, Scaramuzzo, Rosa, Lepiane, Pasquale, Bottari, Andrea, Staderini, Fabio, Cianchi, Fabio, Cavallaro, Andrea, Zanghì, Antonio, Cappellani, Alessandro, Campagnacci, Roberto, Maurizi, Angela, Martinotti, Mario, Ruggieri, Annamaria, Jusoh, Asri Che, Rahman, Karim Abdul, Zulkifli, Anis Suraya M, Petronio, Barbara, Matías-García, Belén, Quiroga-Valcárcel, Ana, Mendoza-Moreno, Fernando, Atanasov, Boyko, Campanile, Fabio Cesare, Vecchioni, Ilaria, Cardinali, Luca, Travaglini, Grazia, Sebastiani, Elisa, Chooklin, Serge, Chuklin, Serhii, Cianci, Pasquale, Restini, Enrico, Capuzzolo, Sabino, Currò, Giuseppe, Filippo, Rosalinda, Rispoli, Michele, Aparicio-Sánchez, Daniel, Muñóz-Cruzado, Virginia Durán, Barbeito, Sandra Dio, Delibegovic, Samir, Kesetovic, Amar, Sasia, Diego, Borghi, Felice, Giraudo, Giorgio, Visconti, Diego, Doria, Emanuele, Santarelli, Mauro, Luppi, Davide, Bonilauri, Stefano, Grossi, Ugo, Zanus, Giacomo, Sartori, Alberto, Piatto, Giacomo, De Luca, Maurizio, Vita, Domenico, Conti, Luigi, Capelli, Patrizio, Cattaneo, Gaetano Maria, Marinis, Athanasio, Vederaki, Styliani-Aikaterini, Bayrak, Mehmet, Altıntas, Yasemin, Uzunoglu, Mustafa Yener, Demirbas, Iskender Eren, Altinel, Yuksel, Meric, Serhat, Aktimur, Yunus Emre, Uymaz, Derya Salim, Omarov, Nail, Azamat, Ibrahim, Lostoridis, Eftychio, Nagorni, Eleni-Aikaterini, Pujante, Antonio, Anania, Gabriele, Bombardini, Cristina, Bagolini, Francesco, Gonullu, Emre, Mantoglu, Bari, Capoglu, Recayi, Cappato, Stefano, Muzio, Elena, Colak, Elif, Polat, Suleyman, Koylu, Zehra Alan, Altintoprak, Fatih, Bayhan, Zülfü, Akin, Emrah, Andolfi, Enrico, Rezart, Sulce, Kim, Jae Il, Jung, Sung Won, Shin, Yong Chan, Enciu, Octavian, Toma, Elena Adelina, Medas, Fabio, Canu, Gian Luigi, Cappellacci, Federico, D'Acapito, Fabrizio, Ercolani, Giorgio, Solaini, Leonardo, Roscio, Francesco, Clerici, Federico, Gelmini, Roberta, Serra, Francesco, Rossi, Elena Giulia, Fleres, Francesco, Clarizia, Guglielmo, Spolini, Alessandro, Ferrara, Francesco, Nita, Gabriela, Sarnari, Jlenia, Gachabayov, Mahir, Abdullaev, Abakar, Poillucci, Gaetano, Palini, Gian Marco, Veneroni, Simone, Garulli, Gianluca, Piccoli, Micaela, Pattacini, Gianmaria Casoni, Pecchini, Francesca, Argenio, Giulio, Armellino, Mariano Fortunato, Brisinda, Giuseppe, Tedesco, Silvia, Fransvea, Pietro, Ietto, Giuseppe, Franchi, Caterina, Carcano, Giulio, Martines, Gennaro, Trigiante, Giuseppe, Negro, Giulia, Vega, Gustavo Machain, González, Agustín Rodríguez, Ojeda, Leonardo, Piccolo, Gaetano, Bondurri, Andrea, Maffioli, Anna, Guerci, Claudio, Sin, Boo Han, Zuhdi, Zamri, Azman, Azlanudin, Mousa, Hussam, Al Bahri, Shadi, Augustin, Goran, Romic, Ivan, Moric, Trpimir, Nikolopoulos, Ioanni, Andreuccetti, Jacopo, Pignata, Giusto, D'Alessio, Rossella, Kenig, Jakub, Skorus, Urszula, Fraga, Gustavo Pereira, Hirano, Elcio Shiyoiti, de Lima Bertuol, Jackson Viníciu, Isik, Arda, Kurnaz, Eray, Asghar, Mohammad Sohail, Afzal, Ameer, Akbar, Ali, Nikolouzakis, Taxiarchis Konstantino, Lasithiotakis, Konstantino, Chrysos, Emmanuel, Das, Koray, Özer, Nazmi, Seker, Ahmet, Ibrahim, Mohamed, Hamid, Hytham K S, Babiker, Ahmed, Bouliaris, Konstantino, Koukoulis, George, Kolla, Chrysoula-Christina, Lucchi, Andrea, Agostinelli, Laura, Taddei, Antonio, Fortuna, Laura, Agostini, Carlotta, Licari, Leo, Viola, Simona, Callari, Cosimo, Laface, Letizia, Abate, Emmanuele, Casati, Massimiliano, Anastasi, Alessandro, Canonico, Giuseppe, Gabellini, Linda, Tosi, Lorenzo, Guariniello, Anna, Zanzi, Federico, Bains, Lovenish, Sydorchuk, Larysa, Iftoda, Oksana, Sydorchuk, Andrii, Malerba, Michele, Costanzo, Federico, Galleano, Raffaele, Monteleone, Michela, Costanzi, Andrea, Riva, Carlo, Walędziak, Maciej, Kwiatkowski, Andrzej, Czyżykowski, Łukasz, Major, Piotr, Strzałka, Marcin, Matyja, Maciej, Natkaniec, Michal, Valenti, Maria Rosaria, Di Vita, Maria Domenica Pia, Sotiropoulou, Maria, Kapiris, Styliano, Massalou, Damien, Veroux, Massimiliano, Volpicelli, Alessio, Gioco, Rossella, Uccelli, Matteo, Bonaldi, Marta, Olmi, Stefano, Nardi, Matteo, Livadoti, Giada, Mesina, Cristian, Dumitrescu, Theodor Viorel, Ciorbagiu, Mihai Calin, Ammendola, Michele, Ammerata, Giorgio, Romano, Roberto, Slavchev, Mihail, Misiakos, Evangelos P, Pikoulis, Emmanouil, Papaconstantinou, Dimitrio, Elbahnasawy, Mohamed, Abdel-Elsalam, Sherief, Felsenreich, Daniel M, Jedamzik, Julia, Michalopoulos, Nikolaos V, Sidiropoulos, Theodoros A, Papadoliopoulou, Maria, Cillara, Nicola, Deserra, Antonello, Cannavera, Alessandro, Negoi, Ionuţ, Schizas, Dimitrio, Syllaios, Athanasio, Vagios, Ilia, Gourgiotis, Stavro, Dai, Nick, Gurung, Rekha, Norrey, Marcu, Pesce, Antonio, Feo, Carlo Vittorio, Fabbri, Nicolo', Machairas, Nikolao, Dorovinis, Panagioti, Keramida, Myrto D, Mulita, Francesk, Verras, Georgios Ioanni, Vailas, Michail, Yalkin, Omer, Iflazoglu, Nidal, Yigit, Direnc, Baraket, Oussama, Ayed, Karim, Ghalloussi, Mohamed Hedi, Patias, Parmenion, Ntokos, Georgio, Rahim, Razrim, Bala, Miklosh, Kedar, Asaf, Sawyer, Robert G, Trinh, Anna, Miller, Kelsey, Sydorchuk, Ruslan, Knut, Ruslan, Plehutsa, Oleksandr, Liman, Rumeysa Kevser, Ozkan, Zeynep, Kader, Saleh Abdel, Gupta, Sanjay, Gureh, Monika, Saeidi, Sara, Aliakbarian, Mohsen, Dalili, Amin, Shoko, Tomohisa, Kojima, Mitsuaki, Nakamoto, Raira, Atici, Semra Demirli, Tuncer, Gizem Kilinc, Kaya, Tayfun, Delis, Spiros G, Rossi, Stefano, Picardi, Biagio, Del Monte, Simone Rossi, Triantafyllou, Tania, Theodorou, Dimitrio, Pintar, Tadeja, Salobir, Jure, Manatakis, Dimitrios K, Tasis, Nikolao, Acheimastos, Vasileio, Ioannidis, Oresti, Loutzidou, Lydia, Symeonidis, Savva, de Sá, Tiago Correia, Rocha, Mónica, Guagni, Tommaso, Pantalone, Desiré, Maltinti, Gherardo, Khokha, Vladimir, Abdel-Elsalam, Wafaa, Ghoneim, Basma, López-Ruiz, José Antonio, Kara, Yasin, Zainudin, Syaza, Hayati, Firdau, Azizan, Nornazirah, Khei, Victoria Tan Phooi, Yi, Rebecca Choy Xin, Sellappan, Harivinthan, Demetrashvili, Zaza, Lekiashvili, Nika, Tvaladze, Ana, Froiio, Caterina, Bernardi, Daniele, Bonavina, Luigi, Gil-Olarte, Angele, Grassia, Sebastiano, Romero-Vargas, Estela, Bianco, Francesco, Gumbs, Andrew A, Dogjani, Agron, Agresta, Ferdinando, Litvin, Andrey, Balogh, Zsolt J, Gendrikson, George, Martino, Costanza, Damaskos, Dimitrio, Pararas, Nikolao, Kirkpatrick, Andrew, Kurtenkov, Mikhail, Gomes, Felipe Couto, Pisanu, Adolfo, Nardello, Oreste, Gambarini, Fabrizio, Aref, Hager, Angelis, Nicola De', Agnoletti, Vanni, Biondi, Antonio, Vacante, Marco, Griggio, Giulia, Tutino, Roberta, Massani, Marco, Bisetto, Giovanni, Occhionorelli, Savino, Andreotti, Dario, Lacavalla, Domenico, Biffl, Walter L, Catena, Fausto, and Apollo - University of Cambridge Repository

Subjects
Male, Cholecystitis, Acute, Acute cholecystitis, Cholecystectomy, COVID-19, Gangrene, Gangrenous cholecystitis, Laparoscopy, Pandemic, SARS-CoV-2, Surgery, Cholecystitis, Acute / epidemiology, Acute cholecystiti, COVID-19 / epidemiology, Postoperative Complications, Sepsis, Cholecystitis, Humans, Cholecystitis, Acute / surgery, Pandemics, Cholecystitis / surgery, Gangrenous cholecystiti, Middle Aged, Postoperative Complications / epidemiology, Emergency Medicine, Female, Cholecystitis / epidemiology
Abstract

Background The incidence of the highly morbid and potentially lethal gangrenous cholecystitis was reportedly increased during the COVID-19 pandemic. The aim of the ChoCO-W study was to compare the clinical findings and outcomes of acute cholecystitis in patients who had COVID-19 disease with those who did not. Methods Data were prospectively collected over 6 months (October 1, 2020, to April 30, 2021) with 1-month follow-up. In October 2020, Delta variant of SARS CoV-2 was isolated for the first time. Demographic and clinical data were analyzed and reported according to the STROBE guidelines. Baseline characteristics and clinical outcomes of patients who had COVID-19 were compared with those who did not. Results A total of 2893 patients, from 42 countries, 218 centers, involved, with a median age of 61.3 (SD: 17.39) years were prospectively enrolled in this study; 1481 (51%) patients were males. One hundred and eighty (6.9%) patients were COVID-19 positive, while 2412 (93.1%) were negative. Concomitant preexisting diseases including cardiovascular diseases (p p p = 0.005) were significantly more frequent in the COVID-19 group. Markers of sepsis severity including ARDS (p p p p p p p p p Conclusions The incidence of gangrenous cholecystitis is higher in COVID patients compared with non-COVID patients admitted to the emergency department with acute cholecystitis. Gangrenous cholecystitis in COVID patients is associated with high-grade Clavien-Dindo postoperative complications, longer hospital stay and higher mortality rate. The open cholecystectomy rate is higher in COVID compared with non -COVID patients. It is recommended to delay the surgical treatment in COVID patients, when it is possible, to decrease morbidity and mortality rates. COVID-19 infection and gangrenous cholecystistis are not absolute contraindications to perform laparoscopic cholecystectomy, in a case by case evaluation, in expert hands. Graphical abstract

Published
2022

13. Effect of peritoneal and wound lavage with super-oxidized solution on surgical-site infection after open appendicectomy in perforated appendicitis (PLaSSo): randomized clinical trial.

Author

Sellappan H, Alagoo D, Loo C, Vijian K, Sibin R, and Chuah JA

Subjects
Humans, Male, Female, Adult, Middle Aged, Therapeutic Irrigation methods, Adolescent, Appendectomy adverse effects, Appendectomy methods, Appendicitis surgery, Surgical Wound Infection prevention & control, Surgical Wound Infection etiology, Peritoneal Lavage methods
Abstract

Background: Surgical-site infection following open appendicectomy for perforated appendicitis increases length of hospital stay and treatment costs while compromising patients' quality of life. Data from randomized clinical trials (RCTs) evaluating the role of super-oxidized solution in perforated appendicitis are lacking. The study objective was to determine the effect of peritoneal and wound lavage with super-oxidized solution in reducing risk of surgical-site infection following open appendicectomy for perforated appendicitis., Methods: In this multicentre RCT conducted between September 2020 and March 2022, patients aged 13 years and older with perforated appendicitis undergoing open appendicectomy were randomly assigned to receive peritoneal and wound lavage with either super-oxidized solution or normal saline. The primary outcome was surgical-site infection within 30 days after surgery. Randomization was computer-generated, with allocation concealment by opaque, sequentially numbered, sealed envelope. The patients, surgeons, outcome assessors and statisticians performing the analysis were blinded to treatment assigned., Results: A total of 102 consecutive patients (51 in the super-oxidized solution group and 51 in the normal saline group) were randomized and included in the intention-to-treat analysis. The super-oxidized solution group showed a significant reduction in overall surgical-site infection (8 (15.6%) versus 19 (37.2%); relative risk (RR) 0.42; 95% c.i. 0.20 to 0.87; P = 0.014), and superficial surgical-site infection (5 (9.8%) versus 18 (35.3%); RR 0.28; 95% c.i. 0.11 to 0.69; P = 0.002), with a number-needed-to-treat of four patients. There were no adverse events in either group., Conclusions: Peritoneal and wound lavage with super-oxidized solution is superior to normal saline in preventing surgical-site infection after open appendicectomy for perforated appendicitis., Trial Registration: ClinicalTrial.gov Identifier: NCT04512196., (© The Author(s) 2024. Published by Oxford University Press on behalf of BJS Foundation Ltd.)

Published
2024
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14. Choledochal cyst and aberrant biliary configuration along with situs inversus totalis: a case report.

Author

Gan DEY, Alagoo D, Chan KH, Choi RXY, Sellappan H, Sharif MS, and Hayati F

Subjects
Adult, Biliary Tract Diseases diagnosis, Biliary Tract Diseases pathology, Choledochal Cyst pathology, Female, Humans, Sepsis diagnosis, Situs Inversus pathology, Choledochal Cyst diagnosis, Choledocholithiasis complications, Sepsis etiology, Situs Inversus diagnosis
Abstract

Situs inversus totalis is the complete transpositioning of thoracoabdominal viscera into a mirror image of the normal configuration. Choledochal cyst is the congenital cystic dilation of the biliary tract. Both these conditions coexisting in a patient is extremely rare. We hereby present a case of type IC choledochal cyst in a patient with situs inversus totalis presenting with biliary sepsis secondary to choledocholithiasis. Also detailed are the management and operative strategies employed to deal with this rare entity., Competing Interests: The authors declare no competing interests., (Copyright: David Eng Yeow Gan et al.)

Published
2021
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