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831 results on '"Selinger, Christian"'

2. Mechanisms and management of loss of response to anti-TNF therapy for patients with Crohn's disease: 3-year data from the prospective, multicentre PANTS cohort study

Author

Patel, Vinod, Mazhar, Zia, Saich, Rebecca, Colleypriest, Ben, Tham, Tony C, Iqbal, Tariq, Kaushik, Vishal, Murugesan, Senthil, Singh, Salil, Weaver, Sean, Preston, Cathryn, Butt, Assad, Smith, Melissa, Basude, Dharamveer, Beale, Amanda, Langlands, Sarah, Direkze, Natalie, Parkes, Miles, Torrente, Franco, De La Revella Negro, Juan, MacDonald, Chris Ewen, Evans, Stephen M, Gunasekera, Anton VJ, Thakur, Alka, Elphick, David, Shenoy, Achuth, Nwokolo, Chuka U, Dhar, Anjan, Cole, Andrew T, Agrawal, Anurag, Bridger, Stephen, Doherty, Julie, Cooper, Sheldon C, de Silva, Shanika, Mowat, Craig, Mayhead, Phillip, Lees, Charlie, Jones, Gareth, Ahmad, Tariq, Hart, James W, Kennedy, Nicholas A, Goodhand, James R, Lin, Simeng, Chanchlani, Neil, Nice, Rachel, McDonald, Timothy J, Bewshea, Claire, Al-Nuaimi, Yusur, Richards, Ellen, Haigh, Richard, Greenish, Huw, Heath, Harry, Gaya, Daniel R, Russell, Richard K, Gervais, Lisa, Dunckley, Paul, Mahmood, Tariq, Banim, Paul JR, Sonwalkar, Sunil, Ghosh, Deb, Phillips, Rosemary H, Azaz, Amer, Sebastian, Shaji, Shenderey, Richard, Armstrong, Lawrence, Bell, Claire, Hariraj, Radhakrishnan, Matthews, Helen, Jafferbhoy, Hasnain, Selinger, Christian P, Zamvar, Veena, De Caestecker, John S, Willmott, Anne, Miller, Richard, Babu, Palani Sathish, Tzivinikos, Christos, Bloom, Stuart L, Chung-Faye, Guy, Croft, Nicholas M, Fell, John ME, Harbord, Marcus, Hart, Ailsa, Hope, Ben, Irving, Peter M, Lindsay, James O, Mawdsley, Joel E, McNair, Alistair, Monahan, Kevin J, Murray, Charles D, Orchard, Timothy, Paul, Thankam, Pollok, Richard, Shah, Neil, Bouri, Sonia, Johnson, Matt W, Modi, Anita, Kabiru, Kasamu Dawa, Baburajan, B K, Bhaduri, Bim, Fagbemi, Andrew Adebayo, Levison, Scott, Limdi, Jimmy K, Watts, Gill, Foley, Stephen, Ramadas, Arvind, MacFaul, George, Mansfield, John, Grellier, Leonie, Morris, Mary-Anne, Tremelling, Mark, Hawkey, Chris, Kirkham, Sian, Charlton, Charles PJ, Rodrigues, Astor, Simmons, Alison, Lewis, Stephen J, Snook, Jonathon, Tighe, Mark, Goggin, Patrick M, De Silva, Aminda N, Lal, Simon, Smith, Mark S, Panter, Simon, Cummings, JR Fraser, Dharmisari, Suranga, Carter, Martyn, Watts, David, Mahmood, Zahid, McLain, Bruce, Sen, Sandip, Pigott, Anna J, Hobday, David, Wesley, Emma, Johnston, Richard, Edwards, Cathryn, Beckly, John, Vani, Deven, Ramakrishnan, Subramaniam, Chaudhary, Rakesh, Trudgill, Nigel J, Cooney, Rachel, Bell, Andy, Prasad, Neeraj, Gordon, John N, Brookes, Matthew J, Li, Andy, Gore, Stephen, Hamilton, Benjamin, Thomas, Amanda, Smith, Rebecca, Roberts, Christopher, Bishara, Maria, and Lees, Charlie W

Published
2024
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3. Episome partitioning and symmetric cell divisions: quantifying the role of random events in the persistence of HPV infections

Author

Beneteau, Thomas, Selinger, Christian, Sofonea, Mircea T., and Alizon, Samuel

Subjects
Quantitative Biology - Populations and Evolution
Abstract

Human Papillomaviruses (HPV) are one of the most prevalent sexually transmitted infections (STI) and the most oncogenic viruses known to humans. The vast majority of HPV infections clear in less than 3 years, but the underlying mechanisms, especially the involvement of the immune response, are still poorly known. Building on earlier work stressing the potential importance of stochasticity in HPV infection clearance, we develop a stochastic mathematical model of HPV dynamics with an explicit description of the intracellular level. We show that the random partitioning of virus episomes upon stem cell division and the occurrence of symmetric divisions greatly affect viral persistence. These results call for more detailed within-host studies to better understand the relative importance of stochasticity and immunity in HPV infection clearance.

Published
2021
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6. Neutralising antibody potency against SARS-CoV-2 wild-type and omicron BA.1 and BA.4/5 variants in patients with inflammatory bowel disease treated with infliximab and vedolizumab after three doses of COVID-19 vaccine (CLARITY IBD): an analysis of a prospective multicentre cohort study

Author

Islam, Madiha, Croft, Nick, Cipriano, Bessie, Francia, Caroline, Khalid, Nosheen, Kingston, Ashley, Lee, Irish, Lehmann, Anouk, Naik, Kinnari, Samuels, Kevin, Plaatjies, Nicolene, Khatun, Hafiza, Bokth, Farjana, Pabriaga, Elise, Saich, Rebecca, Cousins, Hayley, Fraser, Wendy, Thomas, Rachel, Brown, Matthew, White, Benjamin, Kirkineziadis, Nikolaos, Tilley, Bernadette, Porter, Pennie, Bryant, Rachel, Robaczewska, Natalia, Muhammed, Rafeeq, Bi, Rehana, Cotter, Catherine, Grove, Jayne, Hong, Kate, Howman, Ruth, Mitchell, Monica, Clayton, Sophie, Rogers, Louise, Sultan, Sugrah, Rooney, Melanie, Cottrill, Charlotte, Singh, Salil, Dawe, Chris, Hull, Robert, Silva, Natalie, Chadwick, Julie, Robertson, Laura, Manning, Jonathan, Finlayson, Lauren, Roebuck, Allison, Dawson, Joy, Sonwalkar, Sunil, Chambers, Naomi, Robinson, Matthew, Haigh, Andrew, Matapure, Lear, Raine, Tim, George, Varun, Kapizioni, Christina, Strongili, Konstantina, Thompson, Tina, Ahmed, Mohamed, Kontos, Christos, Dawson, Claire, Bourges, Christophe, Barbutti, Isabella, Gozzard, Megan E, Hendy, Philip, Bull, Rhian, Costa, Patricia, Davey, Lisa, Hannington, Hayley, Nundlall, Kribashnie, Martins, Catarina, Avanzi, Laura, Carungcong, Jaime, Barr, Sabrina, Appleby, Richard, Johnson, Emma, Shakweh, Eathar, Phillis, Kath, Gascoyne, Rachel, Crowder, Amanda, Whileman, Amanda, London, Ian, Grounds, Jenny, Martin, Emmeline, Pajak, Susie, Price, Jude, Cawley, Kathryn, Powell, Sandra, Kearsley, Nichola, Dhar, Anjan, Brown, Ellen, Cowton, Amanda, Stamp, Kimberley, Warner, Ben, Stuart, Carmel, Lacey, Louise, de Silva, Shanika, Allcock, Clare, Harvey, Philip, Jones, Lesley, Cooke, Elise, Slater, Jayne, King, Dominic, Brooks, Johanne, Baker, Pearl, Beadle, Hannah, Cruz, Carina, Potter, Debbie, Collum, Joe, Masters, Farzana, Kumar, Aashish, Coetzee, Samantha, Peiu, Mihaela, Icke, Becky, Williams, Jill, Raj, Meena, Gaynor, Edward, Chadokufa, Sibongile, Huggett, Bonita, Meghari, Hamza, El-Khouly, Sara, Kiparissi, Fevronia, Girshab, Waffa, Russell-Walker, Lynda, Jackson, Christopher, Sidler, Sara, Claridge, Andrew, Fowler, Emily, McCafferty, Laura, Haxton, Lesley, Irving, Peter, Christodoulides, Karolina, Clifford, Angela, Dawson, Patrick, Honap, Sailish, Lim, Samuel, Luber, Raphael, Mahiouz, Karina, Meade, Susanna, Raymode, Parizade, Reynolds, Rebecca, Stanton, Anna, Tripoli, Sherill, Hare, Naomi, Odukwe, Sopuluchukwu, Balachandran, Senthuran, North, Emma, North, Jessica, Browne, Bria, Cordle, Jessica, Jameson, Ella, Siaw, Yih Harn, Manzano, Lane, Segal, Jonathan, Al-Bakir, Ibrahim, Khakoo, Imran, Portukhay, Sofiya, Thoua, Nora, Davidson, Katherine, Miah, Jagrul, Canclini, Lisa, Hall, Alex, Furreed, Hassina, Mitchell-Inwang, Christine, Hayes, Melony, Myers, Sally, Talbot, Alison, Turnbull, Jack, Whitehead, Emma, Stamp, Katie, Pattinson, Alison, Mathew, Verghese, Sherris, Leanne, Wilcox, Julie, Ramachandran, Sankaranarayanan, Robertson, Hayley, Harvey, Angela, Hicks, Lucy, Byrne, Tara-Marie, Cabreros, Leilani, Downing-Wood, Hannah, Hunter, Sophie, Saifuddin, Mohammad Aamir, Prabhudev, Hemanth, Balarajah, Sharmili, Krucznski, Jan, Driva, Kalliopi, D'Mello, Andrea, Shah, Parith, Castro-Seoane, Rocio, Ibraheim, Hajir, Constable, Laura E, Lo, Jonathan W, Torkizadeh, Melissa, Hermangild, Sherine K, Sutherland, Helen, Wilhelmsen, Elva, Mackintosh, Katherine, Verma, Ajay M, Sebastian, Juliemol, Peerally, Mohammad Farhad, Guerdette, Anne-marie, Coburn, Susan, Novem lam, Ching Yee, Durrant, Donna, Schaefer, Belinda, Serna, Solange, Shahzad, Muhammad, Kent, Alexandra, Choong, Lee Meng, Pantaloni, Benedetta, Ravdas, Pantelis, Vadamalayan, Babu, Foley, Stephen, Arnold, Becky, Heeley, Cheryl, Lovegrove, Wayne, Sowton, Donna, Allsop, Lynne, Gregory, Heidi, Gill, Mandy, Holmes, Megan, Balan, Valeria, Smith, Susan, Turner, Sarah, Smith, Philip J, Steel, Alan, Bretland, Giovanna, King, Sarah, Lofthouse, Martina, Rigby, Lindsey, Subramanian, Sreedhar, Tyrer, David, Martin, Kate, Probert, Christopher, Kamperidis, Nikolaos, Adedoyin, Temi, Baden, Manisha, Brown, Jeannette, Chacko, Feba, Young, Lisa, Cicchetti, Michela, Saifuddin, Mohammad, Yesupatham, Priya, Gowda, Rohit, Williams, Maureen, Kemp, Karen, Akhand, Rima, Gray, Glaxy, John, Anu, John, Maya, Mohammed, Tasnim, Sathe, Diamond, Jones, Natasha, Soren, Jennifer, Sprakes, Michael, Burton, Julie, Kane, Patricia, Lupton, Stephanie, Bartholomew, Jacqueline, Denis, Elizabeth, Daniels, Alison, MacFaul, George, Scaletta, Diane, Siamia, Loria, Williams, Felicity, Green, Chloe, Ver, Zeljka, Lamb, Chris, Doona, Mary, Hogg, Ashleigh, Jeffrey, Lesley, King, Andrew, Speight, R Alexander, Doyle, Jennifer, Owen, Ruth, Haworth, Jenny, Patterson, Linda, Varnaulasingam, Vithusa, Mowat, Craig, Rice, Debbie, MacFarlane, Susan, MacLeod, Anne, Mohammed, Samera, Murray, Shona, Elliott, Anne, Anne Morris, Mary, Coke, Louise, Hindle, Grace, Kolokouri, Eirini, Wright, Catherine, Lee, Claire, Ward, Nicola, Dann, Adele, Lockett, Melanie, Cranfield, Charlotte, Jennings, Louise, Srivastava, Ankur, Ward, Lana, Jeynes, Nouf, Ranga, Poonam, Rajasekhar, Praveen, Gallagher, Lisa, Ward, Jill, Basnett, Rae, Murphy, Judy, Parking, Lauren, Lawson, Emma, Short, Stacey, Devadason, David, Moran, Gordon, Khan, Neelam, Tarr, Lauren, Olivia, Charmaine, Warbarton, Samantha, Kelly, Sian, Limdi, Jimmy, Goulden, Kay, Javed, Asad, McKenzie, Lauren, Melville, Julie, Liu, Eleanor, Sabine, Joseph, Jacob, Patricia, McSorland, Denise, Schofield, Nick, Cornwall, Lisa, Quirke, James, Crook, Emma, Turner, Anne, Bhandari, Pradeep, Baker-Moffatt, Michelle, Dash, Joanne, Le Poidevin, Alison, Downe, Hayley, Bombeo, Lucille, Blackman, Helen, Smith, Rebecca, Wiles, Alan, Bloxham, Hannah, Dias, Jose, Nadar, Evelyn, Curgenven, Hollie, Gilham, Ellie, Macdonald, Jonathan, Finan, Shona, McMeeken, Faye, Mahmood, Misbah, Shields, Stephanie, Seenan, John Paul, DeSilva, Des, Malkakorpi, Susanna, Carson, Rachel, Lawrence, Holly, Boateng, Ofori, Kpodo, Felix, Whiteoak, Simon, Edger-Earley, Kelli, Vamplew, Luke, Samways, Joanna, Roffe, Sue, Ingram, Sarah, James, Joel, Botfield, Sharon, Hammonds, Fiona, James, Clare, Berry, Zoe, Aspinall, Gemma, Hawkins, Sarah, Parkinson, Marian, Gardner-Thorpe, Helen, Marriott, Suzie, Redstone, Clare, Windak, Halina, Adam, Ana-Marie, Mabb, Hannah, Stevenson, Emma, Record, Jessica, Murray, Charles, Diaba, Cynthia, Joseph, Fexy, Pakou, Glykeria, Gleeson, Yvonne, Nunag, Annalyn, Berrill, James, Stroud, Natalie, Pothecary, Carla, Roche, Lisa, Turner, Keri, Deering, Lisa, Israel, Lynda, Baker, Evelyn, Nash, Maxine, Fagbemi, Andrew, Jennings, Felicia, Mayor, Imelda, Wilson, Jill, Wheeler, Alice, Phillips, Nicola, Gordon, John, Levell, Emma, Zagalo, Silvia, Hoad, Ina, Anil, Bindu, Russell, Richard, Henderson, Paul, Millar, Margaret, Alexakis, Christopher, Michalak, Natalia, Marriott, Cheryl, Stone, Sarah, Pristopan, Veronika, Saunders, John, Burton, Helen, Cambridge, Vanessa, Clark, Tonia, Ekblad, Charlotte, Hierons, Sarah, Katebe, Joyce, Saunsbury, Emma, Perry, Rachel, Brookes, Matthew, Davies, Kathryn, Green, Marie, Plumbe, Ann, Ormerod, Clare, Christensen, Helen, Howlett, Hannah, Keen, Anne, Ogor, Jonathan, Greenhaigh, Marie, Knowles, Karen, Yin, Shanzi, Poulaka, Maria, Anthony, Alpha, Newitt, Emily, Trim, Fiona, Casey, Ruth, Seymour, Katherine, Reed, Catherine, Joy, Lijo, Fogden, Edward, Russell, Kalisha, Hussain, Samia, Phillips, Anne, Abdulla, Muaad, Butterworth, Jeff, Adams, Colene, Carnahan, Mandy, Buckingham, Elizabeth, Childs, Danielle, Magness, Alison, Stickley, Jo, Motherwell, Nichola, Tonks, Louise, Gibson, Hannah, Wistance, Kate, Thomas, Caradog, Brinkworth, Elaine, Connor, Lynda, Cook, Amanda, Rees, Tabitha, Harford, Rachel, Farley, Sean, Jones, Marie, Wesley, Emma, Moss, Alison, Lucas, Jacob, Lorimer, Claire, Oleary, Maria, Dixon, Maxine, Goodchild, Fiona, Twenlow, Rebecca, Pawley, Corinne, Ramadas, Arvind, Tregonning, Julie, Okeke, Olaku, Jackson, Wendy, Koumoutsos, Ioannis, George, Viji, Kunhunny, Swapna, Laverick, Sophie, Anderson, Isla, Smith, Sophie, Joyce, Joan, Janarthan, Sarala, Patel, Kamal, Ali, Mariam, Mhandu, Hilda, Rana, Aleem, Spears, Katherine, Teixeira, Joana, Mencias, Mark, Seaward, Abigail, Sousa, Jessica, Said, Nooria, Soomaroo, Mark, Raspa, Valentina, Tacouri, Asha, Reps, Nicholas, Martin, Rebecca, Samakomva, Tinashe, Selinger, Christian, Carbonell, Jenelyn, Onovira, Felicia, Quartey, Doris, L'Anson, Alice, Ashworth, Andrew, Bailey, Jessica, Dunn, Angie, Bespaloi, Gjuzel, Rasalan, Harold, Mahmood, Zahid, Campbell, Racheal, Marsh, Liane, Coughlan, Tricia, Jafar, Wisam, Marrs, Janet, McPheat, Christopher, Rahman, Monira, Davies, Sarah, Habibi, Ruth, Jessup-Dunton, Ellen, Joefield, Teishel, Layug, Reina, Patel, Vinod, Vere, Joanne, Turner, Victoria, Kilroy, Susan, Coulding, Martina, Clark, Martyn, McCormick, Jacqueline, Nisar, Attiya, Walker, Gareth, Atkins, Stacey, Growdon, Jasmine, George, Becky, McNeill, Charlotte, Reed, Bryony, Foulds, Angela, Marshall, Catherine, Allison, Michele, Dillon, Briony, Cooney, Rachel, Bennett, Lillie, Bowlas, Louise, Shariff, Sharafaath, Fraser, Aileen, Punnette, Dwayne, Lambert, Rebecca, Bishop-Hurman, Charlotte, Undrell, Elizabeth, Belfield, Katherine, Din, Said, Addleton, Catherine, Appleby, Marie, Brown, Johanna, Holding, Kathleen, Fraser, Catherine, Birkenshaw, Janice, Williams, Jodie, Maulion, Kamille, Lane, Meg, Kravale, Arita, Smith, Claud, Hooper, Patricia, deCaestecker, John, Watchorn, Olivia, Clarke, Ellie, Hayward, Chris, Inniss, Susan, Pritchard, Lucy, Rudge, Karen, Carney, Amanda, Griffee, Sarah, Andreyev, Jervoise, Babu, Sathish, Hayhurst, Caroline, Lockwood, Carol, Osborne, Lynn, Roper, Amanda, Warner, Karen, Hindle, Julia, Lawrence, Tara, Netherton, Kimberley, Watt, Caroline, Szymiczek, Kinga, Mehta, Shameer, Bell, James, Blad, William, Whitley, Lisa, Jastrub, Roman, Durai, Dhamaraj, Baker, Mark, John Sivamurugan, Elizabeth, Evans, Mim, Cummings, Fraser, Harris, Clare, Jones, Amy, Krauze, Liga, Rahmany, Sohail, Earl, Michelle, Vowles, Jenny, Torokwa, Audrey, Petrova, Mirela, Procter, Andrew, Stanley, Jo, Silvamoniz, Claudia, Bettey, Marion, Wahid, Amar, Morrison, Zoe, Thomas-Turner, Rhian, Yendle, Louise, Muller, Jennifer, Mitchell, Marcus, Kirkwood, John, Barnes, Anna, Chaudhary, Rakesh, Claridge, Melanie, Ellis, Chiara, Kemp, Cheryl, Tobi, Ogwa, Milton, Jentus, Johnston, Emma, Oblak, Metod, Winpenny, Carmen, Svensson, Marie-Louise, Godden, Jo, Ashhar, Marium, Alexander, Debbie, Covil, Kate, Derikx, Lauranne, Siakavellas, Sryros, Baxter, Helen, Robertson, Scott, Smith, Linda, Poulose, Beena, Colemam, Anne, Balint, Margareta, Rhys-Jones, Gareth, Watters, Helen, Begg, Susan, Grosalcalde, Beatriz, Coyle, Judy, Johns, Kerrie, Hughes, Rachel, Phipps, Janet, Taylor, Abigail, MacPhee, Catherine, Brooks, Suzanne, John, Jolene, Edwards, Michelle, Smith, Katie, Howard, Linda, Wood, Dianne, Muddu, Ajay, Barman, Laura, Mallinson, Janine, Neale, Tania, Ionita, Diana, Elliot, Kerry, Turnball, Alison, Thomas, Iola, Thomas, Alice, Andrews, Kelly, Sutton, Jonathon, Mulvaney Jones, Caroline, Roberts, Julia, Bishop, Jeannie, Liu, Zhigang, Le, Kaixing, Zhou, Xin, Alexander, James L, Lin, Simeng, Bewshea, Claire, Chanchlani, Neil, Nice, Rachel, McDonald, Timothy J, Lamb, Christopher A, Sebastian, Shaji, Kok, Klaartje, Lees, Charlie W, Hart, Ailsa L, Pollok, Richard C, Boyton, Rosemary J, Altmann, Daniel M, Pollock, Katrina M, Goodhand, James R, Kennedy, Nicholas A, Ahmad, Tariq, and Powell, Nick

Published
2023
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8. Etrolizumab versus infliximab for the treatment of moderately to severely active ulcerative colitis (GARDENIA): a randomised, double-blind, double-dummy, phase 3 study

Author

Aboo, Nazimuddin, Ahmad, Tariq, Aldeguer Mante, Xavier, Allez, Matthieu, Almer, Sven, Altwegg, Romain, Andreu Garcia, Montserrat, Arasaradnam, Ramesh, Ardizzone, Sandro, Armuzzi, Alessandro, Arnott, Ian, Aumais, Guy, Avni-Biron, Irit, Barrow, Peter, Beales, Ian, Bermejo San Jose, Fernando, Bezuidenhout, Abraham, Biancone, Livia, Blaeker, Michael, Bloom, Stuart, Bokemeyer, Bernd, Bossa, Fabrizio, Bossuyt, Peter, Bouguen, Guillaume, Bouhnik, Yoram, Bouma, Gerd, Bourdages, Raymond, Bourreille, Arnaud, Boustiere, Christian, Brabec, Tomas, Brand, Stephan, Buening, Carsten, Buisson, Anthony, Cadiot, Guillaume, Calvet Calvo, Xavier, Carbonnel, Franck, Carpio, Daniel, Cheon, Jae Hee, Chiba, Naoki, Chioncel, Camelia, Cimpoeru, Nicoleta-Claudia, Clodi, Martin, Corazza, Gino Roberto, Cosintino, Rocco, Cotter, Jose, Creed, Thomas, Cummings, Fraser, Danese, Silvio, de' Angelis, Gian Luigi, De Maeyer, Marc, Desai, Milind, Desilets, Etienne, Desreumaux, Pierre, Dewit, Olivier, D'Haens, Geert, Dinter, Johanna, Dobru, Ecaterina Daniela, Douda, Tomas, Dumitrascu, Dan Lucian, Ebert, Matthias, Echarri Piudo, Ana, Elkhashab, Magdy, Eun, Chang Soo, Feagan, Brian, Fejes, Roland, Fidalgo, Catarina, Fishman, Sigal, Flourié, Bernard, Fowler, Sharyle, Fries, Walter, Fulop, Csaba, Fumery, Mathurin, G Kiss, Gyula, Gassner, Sonja, Gaya, Daniel, Germanà, Bastianello, Gheorghe, Liliana Simona, Gilletta de Saint Joseph, Cyrielle, Gionchetti, Paolo, Goldis, Adrian-Eugen, Gonçalves, Raquel, Grimaud, Jean-Charles, Gyökeres, Tibor, Hagege, Herve, Haidar, Andrei, Hartmann, Heinz, Hasselblatt, Peter, Hayee, Buhussain, Hebuterne, Xavier, Hellström, Per, Hindryckx, Pieter, Hlavova, Helena, Hoentjen, Frank, Howaldt, Stefanie, Hrdlicka, Ludek, Huh, Kyu Chan, Iborra Colomino, Maria Isabel, Ionita-Radu, Florentina, Irving, Peter, Jahnsen, Jørgen, Jang, ByungIk, Jansen, Jeroen, Jeon, Seong Woo, Jover Martinez, Rodrigo, Juillerat, Pascal, Karlén, Per, Kaser, Arthur, Keil, Radan, Kejariwal, Deepak, Keret, Dan, Khanna, Reena, Kim, Dongwoo, Kim, Duk Hwan, Kim, Hyo-Jong, Kim, Hyun-Soo, Kim, Joo Sung, Kim, Kueongok, Kim, Kyung-Jo, Kim, Sung Kook, Kim, Young-Ho, Klaus, Jochen, Kohn, Anna, Kojecky, Vladimir, Koo, Ja Seol, Kozak, Robert, Kremer, Milan, Kristof, Tunde, Kruger, Frederik, Laharie, David, Lahat-zok, Adi, Landa, Evgeny, Lee, Jonghun, Lee, Kang-Moon, Lee, Kook Lae, Lee, YooJin, Lenze, Frank, Lim, Wee Chian, Limdi, Jimmy, Lindsay, James, Lopez Serrano, Pilar, Louis, Edouard, Lueth, Stefan, Lukas, Milan, Maconi, Giovanni, Mana, Fazia, Mann, Steven, Mansfield, John, Marchi, Santino, Marino, Marco, Marshall, John, Martin Arranz, Maria Dolores, Mateescu, Radu-Bogdan, McLaughlin, John, McLaughlin, Simon, Melzer, Ehud, Mertens, Jessica, Mitrut, Paul, Molnar, Tamas, Muls, Vinciane, Munuswamy, Pushpakaran, Murray, Charles, Naftali, Timna, Naidoo, Visvakuren, Nanabhay, Yusuf, Negreanu, Lucian, Nguyen, Augustin, Ochsenkuehn, Thomas, Orlando, Ambrogio, Panaccione, Remo, Panes Diaz, Julian, Paritsky, Maya, Park, Dong Il, Park, Jihye, Pastorelli, Luca, Peck-Radosavljevic, Markus, Peerani, Farhad, Perez Gisbert, Javier, Peyrin-Biroulet, Laurent, Picon, Laurence, Pierik, Marieke, Ponich, Terry, Portela, Francisco, Prins, Maartens Jeroen, Racz, Istvan, Rahman, Khan Fareed, Reimund, Jean-Marie, Reinshagen, Max, Roblin, Xavier, Rocca, Rodolfo, Rogai, Francesca, Rogler, Gerhard, Salamon, Agnes, Salazar, Ennaliza, Sallo, Zoltan, Samuel, Sunil, Sans Cuffi, Miquel de los Santos, Savarino, Edoardo Vincenzo, Savarino, Vincenzo, Savoye, Guillaume, Schreiber, Stefan, Seicean, Andrada, Selinger, Christian, Serra, David Martins, Shim, Hang Hock, Shin, SungJae, Siegmund, Britta, Siffledeen, Jesse, Simmonds, Wayne, Smid, Jan, Sollano, Jose, Song, Geun Am, Speight, Alexander, Sporea, Ioan, Staessen, Dirk, Stancu, George, Steel, Alan, Stepek, David, Stoica, Victor, Sturm, Andreas, Szekely, Gyorgy, Tan, Teck Kiang, Taxonera Samso, Carlos, Thomson, John, Tichy, Michal, Toth, Gabor Tamas, Tulassay, Zsolt, Vangeli, Marcello, Varga, Marta, Vieira, Ana, Viennot, Stephanie, Villa, Erica, Vitek, Petr, Vogelsang, Harald, Vyhnalek, Petr, Wahab, Peter, Walldorf, Jens, Ye, Byong Duk, Ziady, Christopher, Colombel, Jean-Frederic, Gisbert, Javier P, Hayee, Bu'hussain, Reinisch, Walter, Tyrrell, Helen, Oh, Young S, Tole, Swati, Chai, Akiko, Chamberlain-James, Kirsten, and Tang, Meina Tao

Published
2022
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9. Factors shaping vaginal microbiota community long-term dynamics

Author

Kamiya, Tsukushi, primary, Tessandier, Nicolas, additional, Elie, Baptiste, additional, Bernat, Claire, additional, Boúe, Vanina, additional, Grasset, Sophie, additional, Groc, Soraya, additional, Rahmoun, Massilva, additional, Selinger, Christian, additional, Humphrys, Michael S., additional, Bonneau, Marine, additional, Graf, Christelle, additional, Foulongne, Vincent, additional, Reynes, Jacques, additional, Tribout, Vincent, additional, Segondy, Michel, additional, Boulle, Nathalie, additional, Ravel, Jacques, additional, Murall, Carmen Ĺıa, additional, and Alizon, Samuel, additional

Published
2024
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10. Mechanisms and management of loss of response to anti-TNF therapy for patients with Crohn's disease: 3-year data from the prospective, multicentre PANTS cohort study

Author

Chanchlani, Neil, primary, Lin, Simeng, additional, Bewshea, Claire, additional, Hamilton, Benjamin, additional, Thomas, Amanda, additional, Smith, Rebecca, additional, Roberts, Christopher, additional, Bishara, Maria, additional, Nice, Rachel, additional, Lees, Charlie W, additional, Sebastian, Shaji, additional, Irving, Peter M, additional, Russell, Richard K, additional, McDonald, Timothy J, additional, Goodhand, James R, additional, Ahmad, Tariq, additional, Kennedy, Nicholas A, additional, Patel, Vinod, additional, Mazhar, Zia, additional, Saich, Rebecca, additional, Colleypriest, Ben, additional, Tham, Tony C, additional, Iqbal, Tariq, additional, Kaushik, Vishal, additional, Murugesan, Senthil, additional, Singh, Salil, additional, Weaver, Sean, additional, Preston, Cathryn, additional, Butt, Assad, additional, Smith, Melissa, additional, Basude, Dharamveer, additional, Beale, Amanda, additional, Langlands, Sarah, additional, Direkze, Natalie, additional, Parkes, Miles, additional, Torrente, Franco, additional, De La Revella Negro, Juan, additional, MacDonald, Chris Ewen, additional, Evans, Stephen M, additional, Gunasekera, Anton VJ, additional, Thakur, Alka, additional, Elphick, David, additional, Shenoy, Achuth, additional, Nwokolo, Chuka U, additional, Dhar, Anjan, additional, Cole, Andrew T, additional, Agrawal, Anurag, additional, Bridger, Stephen, additional, Doherty, Julie, additional, Cooper, Sheldon C, additional, de Silva, Shanika, additional, Mowat, Craig, additional, Mayhead, Phillip, additional, Lees, Charlie, additional, Jones, Gareth, additional, Hart, James W, additional, Chanchlani, Neil, additional, Al-Nuaimi, Yusur, additional, Richards, Ellen, additional, Haigh, Richard, additional, Greenish, Huw, additional, Heath, Harry, additional, Gaya, Daniel R, additional, Gervais, Lisa, additional, Dunckley, Paul, additional, Mahmood, Tariq, additional, Banim, Paul JR, additional, Sonwalkar, Sunil, additional, Ghosh, Deb, additional, Phillips, Rosemary H, additional, Azaz, Amer, additional, Shenderey, Richard, additional, Armstrong, Lawrence, additional, Bell, Claire, additional, Hariraj, Radhakrishnan, additional, Matthews, Helen, additional, Jafferbhoy, Hasnain, additional, Selinger, Christian P, additional, Zamvar, Veena, additional, De Caestecker, John S, additional, Willmott, Anne, additional, Miller, Richard, additional, Babu, Palani Sathish, additional, Tzivinikos, Christos, additional, Bloom, Stuart L, additional, Chung-Faye, Guy, additional, Croft, Nicholas M, additional, Fell, John ME, additional, Harbord, Marcus, additional, Hart, Ailsa, additional, Hope, Ben, additional, Lindsay, James O, additional, Mawdsley, Joel E, additional, McNair, Alistair, additional, Monahan, Kevin J, additional, Murray, Charles D, additional, Orchard, Timothy, additional, Paul, Thankam, additional, Pollok, Richard, additional, Shah, Neil, additional, Bouri, Sonia, additional, Johnson, Matt W, additional, Modi, Anita, additional, Kabiru, Kasamu Dawa, additional, Baburajan, B K, additional, Bhaduri, Bim, additional, Fagbemi, Andrew Adebayo, additional, Levison, Scott, additional, Limdi, Jimmy K, additional, Watts, Gill, additional, Foley, Stephen, additional, Ramadas, Arvind, additional, MacFaul, George, additional, Mansfield, John, additional, Grellier, Leonie, additional, Morris, Mary-Anne, additional, Tremelling, Mark, additional, Hawkey, Chris, additional, Kirkham, Sian, additional, Charlton, Charles PJ, additional, Rodrigues, Astor, additional, Simmons, Alison, additional, Lewis, Stephen J, additional, Snook, Jonathon, additional, Tighe, Mark, additional, Goggin, Patrick M, additional, De Silva, Aminda N, additional, Lal, Simon, additional, Smith, Mark S, additional, Panter, Simon, additional, Cummings, JR Fraser, additional, Dharmisari, Suranga, additional, Carter, Martyn, additional, Watts, David, additional, Mahmood, Zahid, additional, McLain, Bruce, additional, Sen, Sandip, additional, Pigott, Anna J, additional, Hobday, David, additional, Wesley, Emma, additional, Johnston, Richard, additional, Edwards, Cathryn, additional, Beckly, John, additional, Vani, Deven, additional, Ramakrishnan, Subramaniam, additional, Chaudhary, Rakesh, additional, Trudgill, Nigel J, additional, Cooney, Rachel, additional, Bell, Andy, additional, Prasad, Neeraj, additional, Gordon, John N, additional, Brookes, Matthew J, additional, Li, Andy, additional, and Gore, Stephen, additional

Published
2024
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17. Assessment, endoscopy, and treatment in patients with acute severe ulcerative colitis during the COVID-19 pandemic (PROTECT-ASUC): a multicentre, observational, case-control study

Author

Abdale, Shukri, Abbasi, Abdullah, Abusrewil, Anwar, Aghimien, Precious, Ahmed, Saeed, Ali, Akram, Ali, Amjad, Alkhoury, Jad, Allen, Patrick, Al-Rifaie, Ammar, Appleby, Richard, Arasaradnam, Ramesh, Arebi, Naila, Arms-Williams, Bradley, Ashraf, Muteeb, Au, Andrea, Avades, Tamar, Ayubi, Homira, Azhar, Saleha, Baillie, Samantha, Balarajah, Sharmili, Bancil, Aaron, Basit, Abdul, Bayati, Murad, Bell, Andrew, Berry, Alexander, Bhat, Shivaram, Bhattacharyya, Joya, Bishop, Sophia, Blackmore, Laura, Bond, Ashley, Borg-Bartolo, Simon, Botwright, Emma, Bouri, Sonia, Boyle, Stephen, Bradley, Neil, Brailsford, Fiona, Britton, Deborah, Brown, Caitlin, Butcher, Rhys, Butterworth, Jeffrey, Campbell, Rachel, Campbell, Roisin, Campbell, Iona, Carr, Ruth, Carter, Josiah, Cartlidge, Peter, Chandy, Rajiv, Chatten, Kelly, Chaudhary, Rakesh, Chee, Desmond, Cheesbrough, Jonathan, Churchhouse, Antonia, Chughtai, Sara, Clough, Jennie, Cole, Alexander, Cook, Johannah, Cooney, Rachel, Cotton, Sarah, Coulter, Archibald, Critchlow, Tamsin, Cuison, Frederic, Curran, Chris, Darie, Ana-Maria, Dart, Robin, Davwar, Pantong, Dawa, Kasamu Kabiru, Dhar, Anjan, Din, Shahida, Diong, Kok Leong, Disney, Benjamin, Dooks, Emma, Downey, Louise, D'Souza, Anita, Dyall, Lovesh, El Masri, Ali El Rida, Elias, Mary, Evans, Holli, Felwick, Richard, Finegan, Michael, Flanagan, Paul, Fofaria, Rishi, Fong, Steven Chung Ming, Fox, Richard, Fraser, Aileen, Frunza, Christian, Ghodeif, Alhassan, Ghosh, Nivedita, Gilroy, Leah, Good, Larissa, Gordon, John, Grasso, Nicola, Guéroult, Aurelién M, Gulliver, James, Guthrie, Sarah, Gwiggner, Markus, Hanna, Mina, Harlow, Christopher, Harrison, Wendy, Hart, Ailsa, Hawthorne, Barney, Henshaw, Julie, Herdman-Grant, Rosaleen, Hooper, Patricia, Howard, Willow, Hussain, Nasir, Hutton, Thomas, Htun, Aye Mya, Irving, Peter, Jagdish, Reema, Javed, Anum, Javed, Asima, Jayasooriya, Nishani, Johnson, Matthew, Johnston, Emma, Jones, Gareth-Rhys, Kanagasundaram, Cynthia, Karagkouni, Fotein, Kemp, Karen, Kemp, Cheryl, Khalil, Hesham, Khan, Najeebullah, Khasawneh, Mais, Khurshid, Bilal, King, Andrew, Kirkham, Beverley, Kirkham, Fiona, Kokwaro, Flora, Korani, Mohamed, Koumoutsos, Ioannis, Kumar, Aditi, Kuzhiyanjal, Anish John Kuriakose, Lakeland, Martyn, Laverick, Sophie, Lees, Charlie, Levell, Emma, Levison, Scott, Lim, Samuel, Lim, Yuen-Hui, Limdi, Jimmy, Lindsay, James Oliver, Lisle, Jessica, Lobo, Alan, Luber, Raphael, Lucaciu, Laura, Lyne, Holly, MacDonald, Jonathan, Mahalingam, Aarani, Mahgoub, Sara, Malakar, Ridhima, Marley, Fenella, Mason, Joy, Mazhar, Zia, McCaughan, Hannah, Naughton, Tracy, McCulloch, Adam, McIlwaine, Stuart, Meah, Nirmol, Mebarek, Leila, Mendall, Mike, Meiarasu, Radharetnas, Mir, Nasir, Mills, Tilly, Milton, Jentus, Moffat, Victoria, Moran, Gordon W, Morris, Liam, Morrison, Gary, Morrison, Graham, Mulligan, Robert, Murray, Charles, Murray, Jennifer, Musharaf, Mutwakil, Myers, Sally, Naeck-Boolauky, Pineshwari, Naranjo, Andres, Navaratnam, Janardhan, Naylor, Deanna, Nixon, Emma, Nixon, Kirsty, Nooredinvand, Hesam Ahmadi, Nosegbe, Uche, Olabintan, Olaolu, Ong Ming San, Elaine, Okpeh, Comfort, Owen, Hayley, Owen, Ruth, Palmer-Jones, Christopher, Peddada, Kalyan, Peerally, Mohammad, Perkins, Rebecca, Phillips, Frank, Pohl, Keith, Pollok, Richard, Powell, Nick, Qayyum, Farah, Qurashi, Maria, Quraishi, Mohammed Nabil, Ratcliffe, Elizabeth, Radford, Shellie, Rahmany, Sohail, Ramadan, Hanin, Ramadas, Arvind, Reddington, Anne, Riley, Tom, Rimmer, Peter, Ritchie, Susan, Roscoe, Jacqueline, Rosiou, Konstantina, Rowland, Siobhan, Sabine, Joseph, Saifuddin, Aamir, Samaan, Mark, Sarkar, Priya, Sarwar, Shahzad, Sasegbon, Ayodele, Saunders, Jayne, Sebepos-Rogers, Gregory, Seenan, John Paul, Selinger, Christian, Serna, Solange, Sethi, Sonika, Shale, Matthew, Shenderey, Richard, Shenoy, Achuth, Sherifat, Yousuf, Sheth, Roosey, Siakavellas, Spyros, Sikafi, Rafid, Singh, Amar, Singh, Salil, Singh, Updesh, Sivaji, Ganesh, Smith, Philip, Speight, R Alexander, Spence, Andy, Stansfield, Catherine, Steed, Helen, Suseeharan, Kishaani, Tabuso, Maria, Taucius, Donatas, Taylor, Joanne, Thakor, Amit, Tham, Tony, Townsend, Gill, Townsend, Tristan, Troth, Thomas, Tunney, Ruth, Turner, Kelly, Umar, Nosheen, Vakeeswarasarma, Vithushan, Verma, Ajay M, Wallace, Hazel, Wallis, Katharina, Walton, Hannah, Wang, Bo, Warner, Eleanor, Watson, Callum, Watson, Eleanor, Wen, Susie, Widlak, Monika, Williams, Maureen, Woods, Amy, Younge, Lisa, Zafar, Mansoor, Sebastian, Shaji, Walker, Gareth J, Kennedy, Nicholas A, Conley, Thomas E, Patel, Kamal V, Subramanian, Sreedhar, Kent, Alexandra J, Segal, Jonathan P, Brookes, Matthew J, Bhala, Neeraj, Gonzalez, Haidee A, Hicks, Lucy C, Mehta, Shameer J, and Lamb, Christopher A

Published
2021
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18. SARS-CoV-2 vaccination for patients with inflammatory bowel disease: a British Society of Gastroenterology Inflammatory Bowel Disease section and IBD Clinical Research Group position statement

Author

Norton, Christine, Din, Shahida, Glatter, Jackie, Kammermeier, Jochen, Ramdeen, Madhoor, Quraishi, Nabil, Sagar, Peter, Radford, Shellie, Speight, R. Alexander, Steed, Helen, Mcfarlane, Michael, Hawthorne, A. Barney, Alexander, James L, Moran, Gordon W, Gaya, Daniel R, Raine, Tim, Hart, Ailsa, Kennedy, Nicholas A, Lindsay, James O, MacDonald, Jonathan, Segal, Jonathan P, Sebastian, Shaji, Selinger, Christian P, Parkes, Miles, Smith, Philip J, Dhar, Anjan, Subramanian, Sreedhar, Arasaradnam, Ramesh, Lamb, Christopher A, Ahmad, Tariq, Lees, Charlie W, Dobson, Liz, Wakeman, Ruth, Iqbal, Tariq H, Arnott, Ian, and Powell, Nick

Published
2021
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22. Detecting Rapid Spread of SARS-CoV-2 Variants, France, January 26-February 16, 2021

Author

Haim-Boukobza, Stephanie, Roquebert, Benedicte, Trombert-Paolantoni, Sabine, Lecorche, Emmanuel, Verdurme, Laura, Foulongne, Vincent, Selinger, Christian, Michalakis, Yannis, Sofonea, Mircea T., and Alizon, Samuel

Subjects
Epidemics -- Statistics -- France, Disease transmission -- Statistics -- Risk factors, Company distribution practices, Health
Abstract

Since the end of 2020, at least 3 strains, or 'variants,' of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) bearing a high number of mutations have been associated with rapid [...]

Published
2021
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23. Current Status, Challenges, and Future Directions in Crohn's Disease.

Author

Selinger, Christian and van der Meulen, Andrea

Subjects
*CROHN'S disease, *INFLAMMATORY bowel diseases, *ULCERATIVE colitis, *DISEASE remission, *COVID-19 pandemic, *BLOOD testing
Abstract

This document is an editorial from the Journal of Clinical Medicine titled "Current Status, Challenges, and Future Directions in Crohn's Disease." It provides an update on the current state of Crohn's disease, including challenges and future directions. The editorial covers various topics related to Crohn's disease, such as early diagnosis, management of perianal Crohn's disease, classification systems, fibrosis, pregnancy management, frailty in older patients, the impact of the COVID-19 pandemic, radiological imaging, and advanced therapies. The authors present a summary of each topic and highlight key findings and recommendations from relevant studies. [Extracted from the article]

Published
2024
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24. Safety, Effectiveness, and Treatment Persistence of Subcutaneous Vedolizumab in IBD: A Multicenter Study From the United Kingdom.

Author

Lim, Samuel Hsiang, Gros, Beatriz, Sharma, Esha, Lehmann, Anouk, Lindsay, James O, Caulfield, Louise, Gaya, Daniel R, Taylor, Jo, Limdi, Jimmy, Kwok, Jon, Shuttleworth, Elinor, Dhar, Anjan, Burdge, Gemma, Selinger, Christian, Cococcia, Sara, Murray, Charles, Balendran, Karthiha, Raine, Tim, George, Becky, and Walker, Gareth

Published
2024
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29. Factors associated with human papillomavirus (HPV) virus load variations in genital infections in young women

Author

Tessandier, Nicolas, primary, Boué, Vanina, additional, Kamyia, Tsukushi, additional, Supplisson, Olivier, additional, Murall, Carmen Lia, additional, Reyné, Bastien, additional, Selinger, Christian, additional, Bernat, Claire, additional, Grasset, Sophie, additional, Groc, Soraya, additional, Rahmoun, Massilva, additional, Bonneau, Marine, additional, Foulongne, Vincent, additional, Graf, Christelle, additional, Tribout, Vincent, additional, Prétet, Jean-Luc, additional, Reynes, Jacques, additional, Segondy, Michel, additional, Bravo, Ignacio G, additional, Boulle, Nathalie, additional, and Alizon, Samuel, additional

Published
2024
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31. The 1918 Influenza Virus PB2 Protein Enhances Virulence through the Disruption of Inflammatory and Wnt-Mediated Signaling in Mice

Author

Forero, Adriana, Tisoncik-Go, Jennifer, Watanabe, Tokiko, Zhong, Gongxun, Hatta, Masato, Tchitchek, Nicolas, Selinger, Christian, Chang, Jean, Barker, Kristi, Morrison, Juliet, Berndt, Jason D, Moon, Randall T, Josset, Laurence, Kawaoka, Yoshihiro, and Katze, Michael G

Subjects
Microbiology, Medical Microbiology, Biomedical and Clinical Sciences, Biological Sciences, Biodefense, Influenza, Vaccine Related, Lung, Prevention, Genetics, Pneumonia & Influenza, Infectious Diseases, Emerging Infectious Diseases, Aetiology, 2.2 Factors relating to the physical environment, 2.1 Biological and endogenous factors, Infection, Good Health and Well Being, Animals, Cell Line, Disease Models, Animal, Female, Gene Expression Profiling, Hemagglutinin Glycoproteins, Influenza Virus, Humans, Inflammation, Influenza A Virus, H1N1 Subtype, Mice, Inbred BALB C, Orthomyxoviridae Infections, RNA-Dependent RNA Polymerase, Reassortant Viruses, Viral Proteins, Virulence, Virulence Factors, Wnt Signaling Pathway, RNA Replicase, Agricultural and Veterinary Sciences, Medical and Health Sciences, Virology, Agricultural, veterinary and food sciences, Biological sciences, Biomedical and clinical sciences
Abstract

UnlabelledThe 1918-1919 influenza pandemic remains the single greatest infectious disease outbreak in the past century. Mouse and nonhuman primate infection models have shown that the 1918 virus induces overly aggressive innate and proinflammatory responses. To understand the response to viral infection and the role of individual 1918 genes on the host response to the 1918 virus, we examined reassortant avian viruses nearly identical to the pandemic 1918 virus (1918-like avian virus) carrying either the 1918 hemagglutinin (HA) or PB2 gene. In mice, both genes enhanced 1918-like avian virus replication, but only the mammalian host adaptation of the 1918-like avian virus through reassortment of the 1918 PB2 led to increased lethality. Through the combination of viral genetics and host transcriptional profiling, we provide a multidimensional view of the molecular mechanisms by which the 1918 PB2 gene drives viral pathogenicity. We demonstrate that 1918 PB2 enhances immune and inflammatory responses concomitant with increased cellular infiltration in the lung. We also show for the first time, that 1918 PB2 expression results in the repression of both canonical and noncanonical Wnt signaling pathways, which are crucial for inflammation-mediated lung regeneration and repair. Finally, we utilize regulatory enrichment and network analysis to define the molecular regulators of inflammation, epithelial regeneration, and lung immunopathology that are dysregulated during influenza virus infection. Taken together, our data suggest that while both HA and PB2 are important for viral replication, only 1918 PB2 exacerbates lung damage in mice infected with a reassortant 1918-like avian virus.ImportanceAs viral pathogenesis is determined in part by the host response, understanding the key host molecular driver(s) of virus-mediated disease, in relation to individual viral genes, is a promising approach to host-oriented drug efforts in preventing disease. Previous studies have demonstrated the importance of host adaptive genes, HA and PB2, in mediating disease although the mechanisms by which they do so are still poorly understood. Here, we combine viral genetics and host transcriptional profiling to show that although both 1918 HA and 1918 PB2 are important mediators of efficient viral replication, only 1918 PB2 impacts the pathogenicity of an avian influenza virus sharing high homology to the 1918 pandemic influenza virus. We demonstrate that 1918 PB2 enhances deleterious inflammatory responses and the inhibition of regeneration and repair functions coordinated by Wnt signaling in the lungs of infected mice, thereby promoting virus-associated disease.

Published
2016

32. Integrated Omics Analysis of Pathogenic Host Responses during Pandemic H1N1 Influenza Virus Infection: The Crucial Role of Lipid Metabolism

Author

Tisoncik-Go, Jennifer, Gasper, David J, Kyle, Jennifer E, Eisfeld, Amie J, Selinger, Christian, Hatta, Masato, Morrison, Juliet, Korth, Marcus J, Zink, Erika M, Kim, Young-Mo, Schepmoes, Athena A, Nicora, Carrie D, Purvine, Samuel O, Weitz, Karl K, Peng, Xinxia, Green, Richard R, Tilton, Susan C, Webb-Robertson, Bobbie-Jo, Waters, Katrina M, Metz, Thomas O, Smith, Richard D, Kawaoka, Yoshihiro, Suresh, M, Josset, Laurence, and Katze, Michael G

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Biological Sciences, Biodefense, Prevention, Influenza, Infectious Diseases, Pneumonia & Influenza, Vaccine Related, Lung, Emerging Infectious Diseases, 2.1 Biological and endogenous factors, 2.2 Factors relating to the physical environment, Aetiology, Infection, Animals, Disease Models, Animal, Ferrets, Gene Expression, Host-Pathogen Interactions, Humans, Influenza A Virus, H1N1 Subtype, Influenza, Human, Lipid Metabolism, Lipids, Metabolomics, Microbiology, Immunology, Biochemistry and cell biology, Medical microbiology
Abstract

Pandemic influenza viruses modulate proinflammatory responses that can lead to immunopathogenesis. We present an extensive and systematic profiling of lipids, metabolites, and proteins in respiratory compartments of ferrets infected with either 1918 or 2009 human pandemic H1N1 influenza viruses. Integrative analysis of high-throughput omics data with virologic and histopathologic data uncovered relationships between host responses and phenotypic outcomes of viral infection. Proinflammatory lipid precursors in the trachea following 1918 infection correlated with severe tracheal lesions. Using an algorithm to infer cell quantity changes from gene expression data, we found enrichment of distinct T cell subpopulations in the trachea. There was also a predicted increase in inflammatory monocytes in the lung of 1918 virus-infected animals that was sustained throughout infection. This study presents a unique resource to the influenza research community and demonstrates the utility of an integrative systems approach for characterization of lipid metabolism alterations underlying respiratory responses to viruses.

Published
2016

34. The 1918 Influenza Virus PB2 Protein Enhances Virulence through the Disruption of Inflammatory and Wnt-Mediated Signaling in Mice.

Author

Forero, Adriana, Tisoncik-Go, Jennifer, Watanabe, Tokiko, Zhong, Gongxun, Hatta, Masato, Tchitchek, Nicolas, Selinger, Christian, Chang, Jean, Barker, Kristi, Morrison, Juliet, Berndt, Jason D, Moon, Randall T, Josset, Laurence, Kawaoka, Yoshihiro, and Katze, Michael G

Subjects
Lung, Cell Line, Animals, Mice, Inbred BALB C, Humans, Reassortant Viruses, Orthomyxoviridae Infections, Disease Models, Animal, Inflammation, RNA Replicase, Viral Proteins, Hemagglutinin Glycoproteins, Influenza Virus, Virulence Factors, Gene Expression Profiling, Virulence, Female, Influenza A Virus, H1N1 Subtype, Wnt Signaling Pathway, RNA-Dependent RNA Polymerase, Mice, Inbred BALB C, Disease Models, Animal, Hemagglutinin Glycoproteins, Influenza Virus, Influenza A Virus, H1N1 Subtype, Biological Sciences, Agricultural and Veterinary Sciences, Medical and Health Sciences, Virology
Abstract

UnlabelledThe 1918-1919 influenza pandemic remains the single greatest infectious disease outbreak in the past century. Mouse and nonhuman primate infection models have shown that the 1918 virus induces overly aggressive innate and proinflammatory responses. To understand the response to viral infection and the role of individual 1918 genes on the host response to the 1918 virus, we examined reassortant avian viruses nearly identical to the pandemic 1918 virus (1918-like avian virus) carrying either the 1918 hemagglutinin (HA) or PB2 gene. In mice, both genes enhanced 1918-like avian virus replication, but only the mammalian host adaptation of the 1918-like avian virus through reassortment of the 1918 PB2 led to increased lethality. Through the combination of viral genetics and host transcriptional profiling, we provide a multidimensional view of the molecular mechanisms by which the 1918 PB2 gene drives viral pathogenicity. We demonstrate that 1918 PB2 enhances immune and inflammatory responses concomitant with increased cellular infiltration in the lung. We also show for the first time, that 1918 PB2 expression results in the repression of both canonical and noncanonical Wnt signaling pathways, which are crucial for inflammation-mediated lung regeneration and repair. Finally, we utilize regulatory enrichment and network analysis to define the molecular regulators of inflammation, epithelial regeneration, and lung immunopathology that are dysregulated during influenza virus infection. Taken together, our data suggest that while both HA and PB2 are important for viral replication, only 1918 PB2 exacerbates lung damage in mice infected with a reassortant 1918-like avian virus.ImportanceAs viral pathogenesis is determined in part by the host response, understanding the key host molecular driver(s) of virus-mediated disease, in relation to individual viral genes, is a promising approach to host-oriented drug efforts in preventing disease. Previous studies have demonstrated the importance of host adaptive genes, HA and PB2, in mediating disease although the mechanisms by which they do so are still poorly understood. Here, we combine viral genetics and host transcriptional profiling to show that although both 1918 HA and 1918 PB2 are important mediators of efficient viral replication, only 1918 PB2 impacts the pathogenicity of an avian influenza virus sharing high homology to the 1918 pandemic influenza virus. We demonstrate that 1918 PB2 enhances deleterious inflammatory responses and the inhibition of regeneration and repair functions coordinated by Wnt signaling in the lungs of infected mice, thereby promoting virus-associated disease.

Published
2015

36. Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study

Author

Patel, Vinod, Mazhar, Zia, Saich, Rebecca, Colleypriest, Ben, Tham, Tony C, Iqbal, Tariq H, Kaushik, Vishal, Murugesan, Senthil, Singh, Salil, Weaver, Sean, Preston, Cathryn, Butt, Assad, Smith, Melissa, Basude, Dharamveer, Beale, Amanda, Langlands, Sarah, Direkze, Natalie, Parkes, Miles, Torrente, Franco, De La Revella Negro, Juan, MacDonald, Chris Ewen, Evans, Stephen M, Gunasekera, Anton V J, Thakur, Alka, Elphick, David, Shenoy, Achuth, Nwokolo, Chuka U, Dhar, Anjan, Cole, Andrew T, Agrawal, Anurag, Bridger, Stephen, Doherty, Julie, Cooper, Sheldon C, de Silva, Shanika, Mowat, Craig, Mayhead, Phillip, Lees, Charlie, Jones, Gareth, Ahmad, Tariq, Hart, James W, Gaya, Daniel R, Russell, Richard K, Gervais, Lisa, Dunckley, Paul, Mahmood, Tariq, Banim, Paul J R, Sonwalkar, Sunil, Ghosh, Deb, Phillips, Rosemary H, Azaz, Amer, Sebastian, Shaji, Shenderey, Richard, Armstrong, Lawrence, Bell, Claire, Hariraj, Radhakrishnan, Matthews, Helen, Jafferbhoy, Hasnain, Selinger, Christian P, Zamvar, Veena, De Caestecker, John S, Willmott, Anne, Miller, Richard, Babu, Palani Sathish, Tzivinikos, Christos, Bloom, Stuart L, Chung-Faye, Guy, Croft, Nicholas M, Fell, John ME, Harbord, Marcus, Hart, Ailsa, Hope, Ben, Irving, Peter M, Lindsay, James O, Mawdsley, Joel E, McNair, Alistair, Monahan, Kevin J, Murray, Charles D, Orchard, Timothy, Paul, Thankam, Pollok, Richard, Shah, Neil, Bouri, Sonia, Johnson, Matt W, Modi, Anita, Kabiru, Kasamu Dawa, Baburajan, B K, Bhaduri, Bim, Fagbemi, Andrew Adebayo, Levison, Scott, Limdi, Jimmy K, Watts, Gill, Foley, Stephen, Ramadas, Arvind, MacFaul, George, Mansfield, John, Grellier, Leonie, Morris, Mary-Anne, Tremelling, Mark, Hawkey, Chris, Kirkham, Sian, Charlton, Charles PJ, Rodrigues, Astor, Simmons, Alison, Lewis, Stephen J, Snook, Jonathon, Tighe, Mark, Goggin, Patrick M, De Silva, Aminda N, Lal, Simon, Smith, Mark S, Panter, Simon, Cummings, J R Fraser, Dharmisari, Suranga, Carter, Martyn, Watts, David, Mahmood, Zahid, McLain, Bruce, Sen, Sandip, Pigott, Anna J, Hobday, David, Wesley, Emma, Johnston, Richard, Edwards, Cathryn, Beckly, John, Vani, Deven, Ramakrishnan, Subramaniam, Chaudhary, Rakesh, Trudgill, Nigel J, Cooney, Rachel, Bell, Andy, Prasad, Neeraj, Gordon, John N, Brookes, Matthew J, Li, Andy, Gore, Stephen, Kennedy, Nicholas A, Heap, Graham A, Green, Harry D, Hamilton, Benjamin, Bewshea, Claire, Walker, Gareth J, Thomas, Amanda, Nice, Rachel, Perry, Mandy H, Chanchlani, Neil, Heerasing, Neel M, Hendy, Peter, Lin, Simeng, Lees, Charlie W, Hart, Ailsa L, Mansfield, John C, Lindsay, James, McDonald, Timothy J, McGovern, Dermot, and Goodhand, James R

Published
2019
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38. A real-world, long-term experience on effectiveness and safety of vedolizumab in adult patients with inflammatory bowel disease: The Cross Pennine study

Author

Lenti, Marco Vincenzo, Levison, Scott, Eliadou, Elena, Willert, Robert, Kemp, Karen, Carter, Anna, Stansfield, Catherine, Assadsangabi, Arash, Singh, Salil, Crooks, Ben, Tattersall, Suzanne, Fairhurst, Francesca, Kenneth, Catherine, Subramanian, Sreedhar, Probert, Chris, Storey, Daniel, Gregg, Belle, Smith, Paul, Liu, Eleanor, Limdi, Jimmy K., Johnston, Alex, Hamlin, Peter John, and Selinger, Christian P.

Published
2018
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40. HPV detection patterns in young women from the PAPCLEAR longitudinal study: implications for HPV screening policies

Author

Bénéteau, Thomas, primary, Groc, Soraya, additional, Murall, Carmen Lia, additional, Boué, Vanina, additional, Élie, Baptiste, additional, Tessandier, Nicolas, additional, Bernat, Claire, additional, Bonneau, Marine, additional, Foulongne, Vincent, additional, Graf, Christelle, additional, Grasset, Sophie, additional, Rahmoun, Massilva, additional, Segondy, Michel, additional, Tribout, Vincent, additional, Reynes, Jacques, additional, Selinger, Christian, additional, Boulle, Nathalie, additional, Bravo, Ignacio G., additional, Sofonea, Mircea T., additional, and Alizon, Samuel, additional

Published
2023
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41. Risankizumab in patients with moderate to severe Crohn's disease: an open-label extension study

Author

Feagan, Brian G, Panés, Julián, Ferrante, Marc, Kaser, Arthur, D'Haens, Geert R, Sandborn, William J, Louis, Edouard, Neurath, Markus F, Franchimont, Denis, Dewit, Olivier, Seidler, Ursula, Kim, Kyung-Jo, Selinger, Christian, Padula, Steven J, Herichova, Ivona, Robinson, Anne M, Wallace, Kori, Zhao, Jun, Minocha, Mukul, Othman, Ahmed A, Soaita, Adina, Visvanathan, Sudha, Hall, David B, and Böcher, Wulf O

Published
2018
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44. Safety, Effectiveness, and Treatment Persistence of Subcutaneous Vedolizumab in IBD: A Multicenter Study From the United Kingdom

Author

Lim, Samuel Hsiang, primary, Gros, Beatriz, additional, Sharma, Esha, additional, Lehmann, Anouk, additional, Lindsay, James O, additional, Caulfield, Louise, additional, Gaya, Daniel R, additional, Taylor, Jo, additional, Limdi, Jimmy, additional, Kwok, Jon, additional, Shuttleworth, Elinor, additional, Dhar, Anjan, additional, Burdge, Gemma, additional, Selinger, Christian, additional, Cococcia, Sara, additional, Murray, Charles, additional, Balendran, Karthiha, additional, Raine, Tim, additional, George, Becky, additional, Walker, Gareth, additional, Aldridge, Robin, additional, Irving, Peter, additional, Lees, Charlie W, additional, and Samaan, Mark, additional

Published
2023
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46. Opioid use and associated factors in 1676 patients with inflammatory bowel disease: a multicentre quality improvement project

Author

Baillie, Samantha, primary, Limdi, Jimmy K, additional, Bassi, Ash, additional, Fraser, Aileen, additional, Parkes, Gareth, additional, Scott, Glyn, additional, Raine, Tim, additional, Lamb, Christopher A, additional, Kennedy, Nicholas A, additional, Fumis, Natalia, additional, Smith, Melissa A, additional, Nicolaou, Andrew, additional, Emms, Holly, additional, Wye, John, additional, Lehmann, Anouk, additional, Carbery, Isabel, additional, Goodhand, James, additional, Lees, Robert, additional, Beshyah, Waleed, additional, Luthra, Pavit, additional, Pollok, Richard, additional, and Selinger, Christian, additional

Published
2023
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47. Reproductive Safety Issues of Novel Small Molecules for the Treatment of Inflammatory Bowel Disease: A Systematic Review.

Author

Monfared, Niloufar, Gold, Matthew, Carbery, Isabel, Laube, Robyn, and Selinger, Christian P.

Subjects
INFLAMMATORY bowel diseases, SMALL molecules, HUMAN abnormalities, MISCARRIAGE
Abstract

Maintenance of remission during pregnancy is vital for women with inflammatory bowel disease (IBD). The antenatal safety of novel small molecules for IBD is yet to be ascertained. We aimed to describe the current evidence on reproductive data regarding small-molecule drugs. We performed a systematic review searching Embase Classic + Embase and Ovid MEDLINE for reproductive outcomes for tofacitinib, filgotinib, upadacitininb, and ozanimod. Additionally, we asked the manufacturers for available data on file regarding reproduction. We analysed data from 10 sources; six studies and four manufacturer reports were identified from our search. Significant malformation risks were reported for tofacitinib, filgotinib, upadacitininb, and ozanimod in animal studies. In 126 tofacitinib-exposed pregnancies, there were 55 live births with 2 congenital malformations and 1 serious infant infection, 14 terminations, 15 miscarriages, and 42 outcomes unknown. In 50 filgotinib-exposed pregnancies, there were 20 healthy babies, 1 congenital malformation, 9 terminations, 10 miscarriages, and 10 outcomes unknown. In 78 upadacitinib-exposed pregnancies, there were 30 healthy babies, 15 terminations, 15 miscarriages, and 18 outcomes unknown. In 60 ozanimod-exposed pregnancies, there were 31 live births with 1 congenital malformation, 1 case of intra-uterine growth restriction, 1 case of neonatal icterus, 13 terminations, 9 miscarriages, and 8 unknown outcomes. Animal data suggest significant risks of malformations for tofacitinib, filgotinib, upadacitininb, and ozanimod. Human data from clinical trials and real-world observations do not show concerning data so far, but these are very limited. Currently, alternative treatments should be used for IBD during pregnancy. [ABSTRACT FROM AUTHOR]

Published
2024
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50. Inflammatory bowel disease patient‐reported quality assessment should drive service improvement: a national survey of <scp>UK IBD</scp> units and patients

Author

Hawthorne, A. Barney, Glatter, Jackie, Blackwell, Jonathan, Ainley, Rachel, Arnott, Ian, Barrett, Kevin J., Bell, Graham, Brookes, Matthew J., Fletcher, Melissa, Muhammed, Rafeeq, Nevill, Alan M., Segal, Jonathan, Selinger, Christian P., St. Clair Jones, Anja, Younge, Lisa, IBD UK Board IBD UK Task And Finish Group, and Lamb, Christopher A.

Subjects
Male, Young Adult, Hepatology, Child, Preschool, Surveys and Questionnaires, Chronic Disease, Gastroenterology, Humans, Pharmacology (medical), Patient Reported Outcome Measures, Inflammatory Bowel Diseases, United Kingdom, Quality of Health Care
Abstract

Summary: Background & Aims: Healthcare service provision in inflammatory bowel disease (IBD) is often designed to meet targets set by healthcare providers rather than those of patients. It is unclear whether this meets the needs of patients, as assessed by patients themselves. This nationwide study assessed patients' experience of IBD and the healthcare they received, aiming to identify factors in IBD healthcare provision associated with perceived high‐quality care. Methods: Using the 2019 IBD Standards as a framework, a national benchmarking tool for quality assessment in IBD was developed by IBD UK, comprising a Patient Survey and Service Self‐Assessment. Results: In all, 134 IBD services and 9757 patients were responded. Perceived quality of care was lowest in young adults then increased with age, was higher in males and those >2 years since diagnosis. No hospital services met all the National IBD Standards for recommended workforce numbers. Key metrics associated with patient‐reported high‐quality care were as follows: identification as a tertiary centre, patient information availability, shared decision‐making, rapid response to contact for advice, access to urgent review, joint medical/surgical clinics and access to research (all p < 0.001). Higher numbers of IBD nurse specialists in a service was strongly associated with patients receiving regular reviews and having confidence in self‐management and reporting high‐quality care. Conclusions: This extensive patient and healthcare provider survey emphasises the importance of aspects of care less often measured by clinicians, such as communication, shared decision‐making and provision of information, and demonstrates that IBD nurse specialists are crucial to meeting the needs of people living with IBD.

Published
2022

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