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AbstractWe conducted a scoping review of peer-reviewed literature published between January 1, 1990 and October 31, 2021, to identify socioeconomic determinants that contribute to higher burden and adverse outcomes in diseases for which self-care is an important modality of treatment and prevention. We identified these diseases using over-the-counter medicines sales data sourced from IQVIA. We searched Ovid Medline, PubMed, and EMBASE databases for articles published in English using inclusion/exclusion criteria. We analyzed articles covering 42 diseases that qualified as cardiovascular disorders (219 studies including ischemic heart disease, myocardial infarction, stroke, and related risk factors such as hypertension, dyslipidemia and atrial fibrillation), nutritional disorders (66 studies including malnutrition which encompasses undernutrition and micronutrient deficiencies, and anemia), digestive disorders (40 studies including gastroesophageal reflux disorder, inflammatory bowel disease, and dyspepsia), allergy disorders (40 studies including asthma and allergic rhinitis), pain disorders (14 studies including lower back pain, knee pain, generalized musculoskeletal pain and headaches), dermatological disorders (23 studies including atopic dermatitis [eczema], occupational dermatosis, and facial dermatitis), respiratory disorders (11 studies including chronic cough, pneumonia, chronic bronchitis, wheezing, and influenza), and gynecological disorders (29 studies including bacterial vaginosis and trichomoniasis vaginosis). We found that lifestyle factors were the commonly reported risk factors, and residential segregation, education, and income were the commonly reported socioeconomic determinants. A closer analysis of income within each disorder revealed that it is more often associated with health conditions that are self-limiting. Although we did not find any discernible relationship between the commonly reported socioeconomic factors and the prevalence of self-medication for the health conditions considered, income plays an important role in the burden and outcomes of conditions that require more self-care compared to those that require less self-care. [ABSTRACT FROM AUTHOR]

The aim of conducting a systematic review of the available literature on antibiotic self-medication was to obtain comprehensive data on prevalence, reasons, common antibiotics, self-treated diseases, and drug and information sources of antibiotics used for self-medication worldwide. PubMed, ScienceDirect, SpringerLink, and Taylor & Francis Online were used to perform a comprehensive search on articles published between 2011 and 2020 in the English language. Studies focusing on the prevalence of antibiotic self-medication and its associated factors were included in this review. AXIS Appraisal tool for Cross-sectional studies (AXIS tool) was used for quality assessment of the included articles. A total of 76 studies from diverse geographical locations, including 62668 individuals, were included in this systematic review. The prevalence of SMA in the included studies ranges from 2.6% to 86.5%. Major reasons for non-prescribed use of antibiotics include healthcare costs and time constraints. Respiratory tract infections, fever, and prophylaxis of various symptoms appeared to be prominent self-treated health issues. Pharmacy or superstore, leftovers, and relatives or friends were the most common sources of acquiring antibiotics for self-medication. Similarly, the majority tend to self-medicate with antibiotics based on information obtained from a pharmacy, previous prescription, or personal experience. Self-medication with antibiotics was considered a pervasive issue, with penicillin being the most commonly self-medicated antibiotic. Lack of public awareness and little attention of researchers to not only self-medication but also other related issues such as antibiotic resistance, necessitates the immediate development and execution of public health policies and multifaceted interventions to ensure rational use of antibiotics eventually reducing antibiotic resistance. [ABSTRACT FROM AUTHOR]

Purpose: Worldwide, trans people are known to take hormones without prescription or take higher or lower doses than prescribed. The study's goal was examination of the social context behind provision and receiving of gender-affirming hormonal therapy (GAHT) in Russia, as well as collection of opinions on the organization of healthcare. Methods: Semi-structured interviews with 20 trans individuals and 6 endocrinologists. Results: Trans respondents started GAHT between 2004 and 2022. Over that period, the number of trans-competent endocrinologists increased and it became easier to receive the diagnosis F64.0 "transsexualism" (ICD-10), which qualifies one to obtain GAHT. However, the majority still took hormones without supervision. The reasons for self-medication included: the lack of the diagnosis, high cost of appointments and tests, age under 18, and self-perceived understanding of principles of GAHT. Most endocrinologists learnt about GAHT after being approached by a trans patient. They received information from advanced training courses and academic literature. The specialists had diverse opinions on the ideal policy of providing GAHT to trans people, but all claimed that in Russian political realities they found the diagnosis "transsexualism" a necessary prerequisite for initiating GAHT to safeguard both doctors and patients. Conclusions: The lack of strict law enforcement in the pharmacological sphere in Russia enabled many trans people to initiate GAHT without supervision. Trans-competent endocrinologists were available for those who needed them. Under current political circumstances it is unlikely that the informed consent model (prescription without a psychiatric diagnosis) can be implemented in Russia. [ABSTRACT FROM AUTHOR]

Background: Authors discuss the connections between novel psychoactive substance (NPS) use and psychological trauma. The transition from classical substances to NPS, a paradigm change, poses a challenge for the treatment systems. Objective: Research evidence suggests difficulties in emotion regulation and trauma-related NPS-use. Authors explore some demographic and psychopathological characteristics related to such findings and examine the connections between emotion regulation deficiency and the choice of substance. Method: This study uses a methodological triangulation of a biologically identified sample to confirm NPS use, a survey method to describe users' socioeconomic characteristics, and Minnesota Multiphasic Personality Inventory (MMPI-2) subscales to study dysfunctions in emotion regulation. Results: Participants (77 patients) were mainly polydrug users. The transgenerational transfer of substance use was a salient feature, but material deprivation was not characteristic of the entire sample. NPS use was not connected to certain psychopathological characteristics the way classical substance use was. More than half of the respondents had elevated scores on MMPI-2 Demoralization (RCd) and Dysfunctional Negative Emotions (RC7) scales. Nearly half of them also scored high on Neuroticism/Negative Emotionality (NEGE). Conclusions: Results suggest that NPS use in the context of polydrug use is connected to psychological trauma and emotion regulation deficiency, but the MMPI-2 scales to assess emotional dysfunctions are not connected to a particular type of NPS. [ABSTRACT FROM AUTHOR]

In recent years, cannabis use by people suffering from PTSD, as a means of alleviating their symptoms, has increased. Nonetheless, scant research has examined the lived experience of women who use cannabis to cope with PTSD. Eight semi-structured interviews with Israeli women who use cannabis to cope with PTSD were analyzed using interpretative phenomenological analysis (IPA). The results of this research highlight the utility of cannabis for women coping with symptoms of PTSD, and the advantages of cannabis over other medications. Nevertheless, the main challenge with cannabis use in the context of PTSD is the feeling of detachment that it engenders. This feeling of detachment helps women to manage symptoms when they become unbearable but can also reduce their ability to be fully present in their relationships and everyday life, and increase feelings of self-alienation and helplessness. [ABSTRACT FROM AUTHOR]

Background: Pneumonia is an acute respiratory infection caused by several infectious agents, such as viruses, bacteria, and fungi. It affects the lungs. This study aimed to assess mothers' knowledge and practices regarding pneumonia in children under five years of age in Makambako town. The study focused on exploring knowledge, awareness, practices, and the extent to which mothers understand the disease and measures taken to protect children to prevent and reduce the disease prevalence. Methodology: A community-based descriptive cross-sectional study design was used, employing random and purposive sampling techniques to obtain 106 respondents in the study area who filled out the structured questionnaires. All questionnaires were checked for completeness and then entered into SPSS for analysis. The prevalence is high, as there were 2647 cases of pneumonia in 2017 compared to 1938 cases in 2016. Results: Based on the study findings, the high prevalence of childhood pneumonia in Makambako town council is caused by low knowledge and poor practices of mothers concerning childhood pneumonia, as 70.8% of mothers do not know what pneumonia is about, 72.6% of mothers do not know health risk factors associated with childhood pneumonia, and 77.3% do not know how pneumonia is transmitted. Some mothers perform cultural and traditional beliefs, while others perform self-medication and take a child to the hospital when the conditions worsen. Most do not know if proper nutrition and immunization, as signified by 99% and 81%, respectively, are the most effective ways to protect a child against pneumonia. Conclusion and recommendations: The study concludes that mothers' knowledge and practices associated with improper nutrition and immunization contribute much to children's pneumonia. Therefore, the study suggests proper nutrition and immunization education should be done appropriately to protect children from pneumonia. [ABSTRACT FROM AUTHOR]

Background: Consecutive visitors to a public science event at Leipzig University were asked about their opinions/attitudes regarding their personal use of self-medication. Methods: A written questionnaire survey addressed (i) participants' characteristics, (ii) frequency of self-medication use in the last 12 months, (iii) symptoms/complaints most frequently considered applicable, (iv) preconditions, (v) limitations, (vi) risks, (vii) fears, (viii) medication information sources, (ix) influencing factors, and (x) reasons for decision making. Results: (i) A total of 189 visitors (median age: 29.0 years; Q25/Q75: 22.0/44.0) participated, of whom 64.0% were female, 38.6% had a university degree, 20.1% were in training, and 14.8% were licensed in a healthcare profession. (ii) A total of 59.3% of participants stated that they had used self-medication regularly in the last 12 months. The most common answers in the respective questions were (iii) headache, 86.2%; (iv) mild complaints/symptoms, 94.7%; (v) duration, 91.6%; (vi) "self-medication may cause adverse drug reactions", 94.2%; (vii) "developing a habituation effect", 58.7%; (viii) pharmacists, 93.7%; (ix) "physician's recommendation", 89.3%; (x) "intensity of complaints", 92.6%; and (vi) 61.3% believed that they could choose an appropriate self-medication. Conclusion: Younger and well-educated adults report using self-medication frequently and rate their expertise as high. Healthcare professionals are the preferred source of information. [ABSTRACT FROM AUTHOR]

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The objective of this study was to investigate self-medication behavior among Chinese adolescents aged 12–18 years and explore the factors associated with whether adolescents prioritize drug efficacy or safety when engaging in self-medication behavior. In 2021, a questionnaire investigation was conducted in the Chinese mainland using a multi-stage sampling approach. After a statistical description, logistic regression was used to analyze the factors associated with considering drug efficacy and safety. The self-medication rate among Chinese adolescents aged 12–18 years was 96.61%. Of these, 65.84% considered drug safety to be essential, while 58.72% prioritized drug efficacy. Regression analysis showed that individuals with better healthcare were more likely to consider drug efficacy an important factor. Additionally, those with a healthier family lifestyle were more likely to prioritize efficacy. When individuals engage in self-medication, those residing in urban areas and possessing advanced preventive health literacy and ample family health resources tend to prioritize drug safety to a greater extent. Conversely, those with higher monthly household incomes and only children exhibit a decreased inclination towards prioritizing safety during self-medication. Self-medication is a frequently observed practice among Chinese adolescents aged 12–18. Several factors, such as demographic and sociological characteristics, health literacy, and family health status, have been found to be associated with the extent to which adolescents prioritize medication safety and efficacy when engaging in self-medication practices. Higher levels of health literacy and better family health status were positively correlated with considering both the efficacy and safety of drugs as important factors when self-medicating. [ABSTRACT FROM AUTHOR]

We analyzed data from positively tested COVID-19 outpatients to describe self-medication with OTC drugs and use of other remedies against symptoms of SARS-CoV-2 infection. We specifically considered their type and frequency, as well as associations with patient characteristics, and reasons for use. Data were collected between May 1, 2020 and February 22, 2021 with two questionnaires in an observational cohort study with PCR-confirmed SARS-CoV-2-positive adult outpatients in the district of Western Pomerania in Germany. 523 out of 710 outpatients (74%; 340 women and 183 men) reported using drugs and other remedies to relieve COVID-19-symptoms. Overall, participants reported utilization of 1282 finished dosage products or remedies, including 213 different ingredients. In the population of 710 outpatients, utilization of ibuprofen (26%), acetaminophen (21%), metamizole (14%), and acetylsalicylic acid (10%) was most commonly reported. Phytopharmaceuticals, herbal and animal products as well as vitamins and minerals were also frequently reported. Among the 523 participants who used drugs and other remedies, most commonly mentioned reasons for use were headache (40%), other kinds of pain (e.g. myalgia; 37%), fever (24%) and cough (16%). Our analysis showed that a majority of the participants tried to alleviate COVID-19-symptoms using drugs and other remedies. Especially analgesic and antipyretic agents, followed by herbal medicines, were used very frequently. Trial registration: German Register for Clinical Studies DRKS00021672, first registration on December 1st, 2020. [ABSTRACT FROM AUTHOR]

Background: Self-medication practices involve the use of medications without healthcare professional requests. The threat of coronavirus disease 2019 (COVID-19) caused the practice of a fittest to survive action, with the assumption that something is better than nothing. Moreover, owing to the lack of effective treatment for COVID-19, the general public has shifted toward self-medication and symptomatic treatment, with approximately 80% of people stockpiling medication for use during the pandemic. Thus, this study aimed to assess the factors associated with self-medication practices during the COVID-19 pandemic crisis in southwestern Ethiopia. Methods: A community-based cross-sectional study design was employed at selected drug retail outlets in southwestern Ethiopia for 415 community pharmacy clients from July 1, 2021, to September 1, 2021. Purposive sampling techniques were employed to select five drug retail outlets on the basis of high patient flows, and we took the study participants until the required quota allotted to each selected drug retail outlet had been filled. Bivariable and multivariable logistic regression analyses were employed to identify factors associated with self-medication. AORs with 95% CIs were used to report associations, and the level of significance was set at P < 0.05. Results: Self-medication was significantly associated with being female (AOR 3.51, 95% CI 1.04–12.41), having a college education or above (AOR 47, 95% CI 4.32–55.21), time wastage at public health facilities (AOR 2.71, 95% CI 3.47–5.21), being afraid of contracting COVID-19 (AOR 0.006, 95% CI 0.004–0.185), and having high fees at public health facility (AOR 0.006, 95% CI 0.004–0.185). The most frequently used medications to treat or prevent the COVID-19 pandemic were analgesics (42.4%) and cold medicines (29.5%). Headache (22.2%), fever (13.2%), respiratory infection (14.3%), and cold (21.4%) were the most frequently reported symptoms of the COVID-19 pandemic. Conclusion: This study revealed high self-medication practices among study area residents during the COVID-19 pandemic. The primary reasons for self-medication in the context of COVID-19 are fear of the pandemic and time wastage at public health facilities. Therefore, special attention should be given to educating public and health care providers on the types of illnesses that can be self-diagnosed and self-treated and the types of drugs to be used for self-medication. [ABSTRACT FROM AUTHOR]

Syphilis is a sexually transmitted disease with a wide range of clinical manifestations. Given the recent worldwide resurgence of syphilis, it is imperative to recognise various presentations of this great imitator. Apart from the classic ulcerative lesion of primary syphilis, known as a hard chancre, atypical presentations mimicking other diseases are also reported. A patient with carcinoma of the lip who was scheduled for surgery was diagnosed with an extragenital chancre during routine presurgery screening, leading to a change in the treatment plan for the patient. Other patients were initially treated for conditions such as scrotal eczema, psoriasis, and herpes before the correct diagnosis was made. Rare presentations, such as pustular lesions, paraphimosis, and cord-like thickening of the penis, were also observed in this case series. It is important to recognise these atypical manifestations, as doing so may facilitate early diagnosis and prompt management. Nine cases of syphilis in patients who exhibited atypical manifestations are presented in this case series and were diagnosed based on a high index of suspicion aided by laboratory confirmation. [ABSTRACT FROM AUTHOR]

Objective: To determine the prevalence and factors associated with self-medication among students with medical and non-medical backgrounds in Peshawar, Khyber Pakhtunkhwa. Study Design: Cross-sectional study. Setting: Medical and Non-medical Universities of Peshawar. Period: May to October 2022. Methods: For this comparative analysis, sample size was calculated based on the formula of Cochran, taking a 95% confidence level with 5% precision. The sampling was conducted using a non-probability convenience approach. Data was collected using a structured questionnaire and analyzed with the help of SPSS v.25. Results: A study sample of 427 participants with a 95% response yielded 212 medical students and 215 non-medical students. The prevalence of self-medication among medical and non-medical students was 35.36% and 39.35%, respectively. The occurrence of self-medication was reported as 7% daily, 11% weekly, 11% fortnightly, and 71% monthly. Among the reasons for self-medication, headache was the most common (49.65%), followed by cough/sore throat/cold (31.85%), fever (26.46%), generalized body aches (17.56%), heartburn/indigestion (14.75%), nausea/vomiting (9.36%), constipation (4.91%), anxiety/depression (4.68%), and insomnia (3.51%), while 8.89% constitutes other factors like allergies, skin rashes, and weight loss. The main reason for self-medication was the mild nature of the illness, which accounted for 31.85% of cases. Conclusion: The study indicated a considerable number of student population involved in self-medication practices. The prevalence of this behavior was slightly more common among non-medical students than medical students. Various factors contributed to self-medication ranging from physical symptoms to mental health issues. [ABSTRACT FROM AUTHOR]

Some studies have reported that community pharmacies in developing countries, including Indonesia, provided sub-optimal advice when handling patient's self-medication request for cough. The reasons behind such advice, therefore, need to be investigated. To describe Indonesian pharmacists' clinical decision making when handling self-medication cases for a cough. An open-ended questionnaire consisting of two cough clinical vignettes (case 1: cough due to asthma worsening and case 2: cough as a symptom of common cold) were developed. Pharmacists were interviewed to provide recommendations and reasons for their recommendations for these scenarios. Content analysis was used to analyse participants' statements for the two scenarios. The number of participants who provided appropriate recommendations and reasons were then counted. A total of 245 community pharmacists participated in the study. In the case of cough due to asthma worsening, recommending a product because the product was indicated to help with the symptoms was the most common recommendation and stated reason (40%). Appropriate recommendation (direct medical referral) with appropriate reasoning (indicating warning symptoms and/or making a symptom diagnosis) was provided by 25% participants. In the case of cough as a symptom of common cold, recommending products to help with the symptoms was also the most common recommendation and stated reason (53%). Appropriate recommendations (recommending product) with appropriate reasoning (providing product to treat the symptoms and/or indicating no warning symptoms and/or making a symptom diagnosis) was provided by 81% participants. The ability of Indonesian community pharmacists to provide appropriate recommendations for cough self-medication requests is dependent on whether triage is required. The inability of most community pharmacists to differentiate between major and minor conditions may lead to serious health implications for patients and therefore educational interventions should be undertaken to improve community pharmacists' differential diagnostic skills for triage. [ABSTRACT FROM AUTHOR]

Self-medication (SM) forms an important part of public health strategy. Nonetheless, little research has been performed to understand the current state of self-medication in the European Union (EU). Utilizing data from the third wave of the European Health Interview Surveys, this study finds an estimated SM prevalence of 34.3% in the EU (95%CI = 34.1-34.5%; n = 255,758). SM prevalence, as well as SM prevalence inequality between men and women, varies substantially between EU member countries. Via multivariable analysis, we also identify a number of variables associated with SM, most notably the substantial impact of health systems on SM behavior (Adjusted Odds Ratio [AOR] = 4.00; 95% Confidence Interval [95%CI] = 3.81–4.21). Several demographics are also associated with greater SM prevalence, including those aged 25–44 (versus ages 75+: AOR = 1.21; 95%CI = 1.12–1.31), women (AOR = 1.74; 95%CI = 1.68–1.81), immigrants born in other EU states (AOR = 1.16; 95%CI = 1.04–1.30), those with higher education (AOR = 1.83; 95%CI = 1.60–2.09), and urban dwellers (AOR = 1.14; 95%CI = 1.04–1.30). Additionally, long-standing health problems (AOR = 1.39; 95%CI = 1.33–1.45), visits to doctors (both general practitioners and specialists) (AOR = 1.21, 95%CIs = 1.15–1.26, 1.17–1.26), and unmet needs for health care due to waiting lists (AOR = 1.38; 95%CI = 1.23–1.55) or inability to afford medical examinations/treatment (AOR = 1.27; 95%CI = 1.12–1.42) serve as conditioners for SM. We also find that smoking (AOR = 1.05; 95%CI = 1.01–1.10), vaping (AOR = 1.19; 95%CI = 1.06–1.32), drinking alcohol (AOR = 1.23; 95%CI = 1.19–1.28), and higher levels of physical activity (AOR = 1.27; 95%CI = 1.22–1.32) are factors associated with SM. Analysis of these variables reveals that though women self-medicate more than men, the patterns that govern their consumption are similar. [ABSTRACT FROM AUTHOR]

(1) Background: The rise of online health resources and AI has reshaped the diagnosis and treatment of disease, altering the relationship between patients and healthcare professionals and encouraging self-medication. However, questionnaires validated in the literature on self-medication seem to lack questions on the possible causes that induce such behaviors, including items that explore trust toward websites and artificial intelligence. The aim of this study is to design and validate the content of a questionnaire designed to assess self-medication in health professionals, delving into the underlying etiologies, the pharmacological categories involved and the degree of confidence placed in clinical assessments derived from AI tools. (2) Methods: Validation study of the content of an instrument consisting of two phases: 1. The content validation phase involved evaluation by a selected group of health experts, who, using a Likert-type scale, analyzed the clarity, coherence and relevance of the items. 2. Pilot study of health professionals who have indicated the practice of self-administration of medications. (3) Results: In the first phase of the study, the experts considered most of the questionnaire items to be clear, representative and consistent with the construct to be measured. In its second phase, the preliminary results of our pilot study suggest a significant trend toward self-medication among healthcare workers, along with a strong inclination to use online resources to search for health-related information. (4) Conclusions: The development of a validated instrument to measure the influence of the different causes that lead healthcare personnel to practice self-medication, guaranteeing validity and efficacy, allows us to establish strategies to reduce this growing problem. [ABSTRACT FROM AUTHOR]

Background and aim: Self‐medication is a common practice worldwide, and its prevalence ranges between 20% and 80% among patients suffering from dental pain. The socioeconomic status of an individual plays a key role in self‐medication practice, especially sex and education level. This study aims to investigate the extent of self‐medication practice for toothache due to dental caries among adults in Dar es Salaam, Tanzania. Methods: This was an analytical cross‐sectional study carried out over 6 months. It included adult patients presenting with toothache in public dental clinics. A questionnaire captured information on demography, self‐medication practice, the substance used for self‐medication, duration of self‐medication, and reason for self‐medication. Univariate analysis was carried out to assess factors associated with self‐care remedies. The probability level of α < 0.05 was selected for statistical significance. Results: A total of 420 participants took part in this survey with a majority (54.3%) being females. The ages of the participants ranged between 18 years and 79 years, with a mean age of 33.37 (SD = 12.64) years. Nearly all (98.5%) participants used some sort of self‐prescribed remedies for managing toothache before attending a dental clinic for appropriate treatment. The sociodemographic status of the participants did not influence the practice of self‐medication. Conclusion: About 98% of patients suffering from toothache in Tanzania practice self‐medication, and it cuts across all social strata of the adult dental population Patient or Public Contribution: Patients with toothache secondary to dental caries participated in the pilot study and were consulted on the suitability of the study tool. [ABSTRACT FROM AUTHOR]

Background: Self-medication is a concern at the global level. It comes with complications and different health issues. This study measures the prevalence, influential factors, and reasons behind self-medication. Methods: A descriptive cross-sectional study was conducted at Imam Mohammad Ibn Saud Islamic University. The prevalence and influential factors were measured between September and November 2023. Statistical analysis was performed using RStudio (R version 4.3.1). We used frequencies and percentages to present categorical variables. Using a convenient sampling technique. Factors associated with using self-medication and the differences between students of the medical college and their non-medical counterparts were assessed using Pearson’s Chi-squared test or Fisher’s exact test. Statistical significance was considered at P < 0.05. Result: We initially received 410 responses on the online platform. However, we excluded seven responses from those who disagreed to participate and 12 from participants outside Riyadh. The majority of the participants were female (67.5%). Three hundred nineteen (319) participants indicated that they had ever used self-medications, accounting for a prevalence of 81.6%. Regarding the reasons for self-medication, the most frequently cited factors were ‘previous experience’ (66.5%) and ‘time-saving’ (50.2%). Additionally, the primary source of drug information utilized for self-medication practices was predominantly from ‘relatives/friends’ (62.4%) and ‘pharmacologists’ (48.0%). Medications were primarily used for headache (76.8%), fever (48.6%), and pain (47.3%). The most commonly used classes of drugs used for self-medication were painkillers (84.0%), vitamins (42.0%), and eye drops (32.9%). Conclusion: The results showed that the prevalence of self-medication is high in the surveyed population. There has been an association between monthly income and the prevalence of self-medication. As pharmacists are the second most common source of drug information, it is essential to increase responsibility and avoid marketing and personal benefiting behavior as they are considered a reliable source of information in the population. Healthcare organizers can utilize our study to educate people about the adverse effects of self-medication.

Abstract We analyzed data from positively tested COVID-19 outpatients to describe self-medication with OTC drugs and use of other remedies against symptoms of SARS-CoV-2 infection. We specifically considered their type and frequency, as well as associations with patient characteristics, and reasons for use. Data were collected between May 1, 2020 and February 22, 2021 with two questionnaires in an observational cohort study with PCR-confirmed SARS-CoV-2-positive adult outpatients in the district of Western Pomerania in Germany. 523 out of 710 outpatients (74%; 340 women and 183 men) reported using drugs and other remedies to relieve COVID-19-symptoms. Overall, participants reported utilization of 1282 finished dosage products or remedies, including 213 different ingredients. In the population of 710 outpatients, utilization of ibuprofen (26%), acetaminophen (21%), metamizole (14%), and acetylsalicylic acid (10%) was most commonly reported. Phytopharmaceuticals, herbal and animal products as well as vitamins and minerals were also frequently reported. Among the 523 participants who used drugs and other remedies, most commonly mentioned reasons for use were headache (40%), other kinds of pain (e.g. myalgia; 37%), fever (24%) and cough (16%). Our analysis showed that a majority of the participants tried to alleviate COVID-19-symptoms using drugs and other remedies. Especially analgesic and antipyretic agents, followed by herbal medicines, were used very frequently. Trial registration: German Register for Clinical Studies DRKS00021672, first registration on December 1st, 2020.

Abstract Background Despite their significant contribution to reducing mortality and morbidity from infectious diseases, antibiotics face challenges due to their inappropriate use, one of which is self-medication. This study assessed the prevalence of|| self-medication with antibiotics among Eritrean college students and its associated factors. Methods An analytical cross-sectional study evaluated the prevalence of self-medication with antibiotics among students from five colleges from September 2019 to February 2020. Participants were selected through simple random sampling, and each participant completed a structured questionnaire covering socio-demographic characteristics, knowledge and attitudes toward antibiotics, and self-medication practices. Logistic regression analysis was employed to identify factors associated with self-medication with antibiotics. Results The study distributed 380 questionnaires, with 375 returned, yielding a response rate of 98.68%. Findings revealed that 80.3% of participants were familiar with antibiotics. Additionally, 18.8% agreed with non-prescription antibiotic use for simple ailments. Of the 252 respondents who answered, 67.1% reported self-medication with antibiotics. Within the preceding six months, the prevalence of such self-medication was 34.3%. Factors associated with self-medication included college affiliation, with participants from the College of Science (COS) exhibiting lower odds (AOR = 0.38, 95% CI: 0.16–0.91, p = 0.03) compared to the College of Business and Social Sciences (CBSS) students. Those living in dormitories had 2.4 times higher odds (AOR = 2.42, 95% CI: 1.7–5.02, p = 0.017) to self-medicate compared to those living with family. Moreover, individuals unaware of antibiotic resistance had higher odds (AOR = 2.41, 95% CI: 1.24–4.7, p = 0.009) of self-medication. Attitude score was also significantly associated with self-medication (AOR = 0.88, 95% CI: 0.8–0.98, p = 0.027). Conclusions These results highlight the necessity for tailored educational programs to advocate for appropriate antibiotic utilization and mitigate the prevalent misuse of antibiotics among college students. Initiatives focused on increasing knowledge about the dangers linked with self-medication and advocating for conscientious antibiotic usage are essential in combating the escalating challenge of antibiotic resistance and safeguarding public health.

Syphilis is a sexually transmitted disease with a wide range of clinical manifestations. Given the recent worldwide resurgence of syphilis, it is imperative to recognise various presentations of this great imitator. Apart from the classic ulcerative lesion of primary syphilis, known as a hard chancre, atypical presentations mimicking other diseases are also reported. A patient with carcinoma of the lip who was scheduled for surgery was diagnosed with an extragenital chancre during routine presurgery screening, leading to a change in the treatment plan for the patient. Other patients were initially treated for conditions such as scrotal eczema, psoriasis, and herpes before the correct diagnosis was made. Rare presentations, such as pustular lesions, paraphimosis, and cord-like thickening of the penis, were also observed in this case series. It is important to recognise these atypical manifestations, as doing so may facilitate early diagnosis and prompt management. Nine cases of syphilis in patients who exhibited atypical manifestations are presented in this case series and were diagnosed based on a high index of suspicion aided by laboratory confirmation.

Abstract Background Self-medication practices involve the use of medications without healthcare professional requests. The threat of coronavirus disease 2019 (COVID-19) caused the practice of a fittest to survive action, with the assumption that something is better than nothing. Moreover, owing to the lack of effective treatment for COVID-19, the general public has shifted toward self-medication and symptomatic treatment, with approximately 80% of people stockpiling medication for use during the pandemic. Thus, this study aimed to assess the factors associated with self-medication practices during the COVID-19 pandemic crisis in southwestern Ethiopia. Methods A community-based cross-sectional study design was employed at selected drug retail outlets in southwestern Ethiopia for 415 community pharmacy clients from July 1, 2021, to September 1, 2021. Purposive sampling techniques were employed to select five drug retail outlets on the basis of high patient flows, and we took the study participants until the required quota allotted to each selected drug retail outlet had been filled. Bivariable and multivariable logistic regression analyses were employed to identify factors associated with self-medication. AORs with 95% CIs were used to report associations, and the level of significance was set at P

Background and Aim: Self-medication practices (SMPs) are a common phenomenon prevalent with both prescription and nonprescription medicines. Still, the availability of a valid and reliable instrument to assess the knowledge, attitude, and practices toward self-medication (SM) remains limited. The current pilot study aimed to develop and validate a tool that effectively evaluates these aspects among consumers in Delhi, India. Materials and Methods: The research involved 100 consumer participants from Delhi, India. Reliability and validity testing was conducted to assess reproducibility, internal consistency, and content validity. The questionnaire underwent validation by a panel of five experts to evaluate face and content validity. Results: Test–retest reliability was assessed using Karl Pearson’s correlation co-efficient yielding values of 0.841 (P = 0.002), 0.827 (P = 0.003), and 0.792 (P = 0.006) for the three domains of knowledge, attitude, and frequency of performing SM, respectively. Cronbach’s alpha statistics were used to determine internal consistency, yielding values of 0.775 and 0.839 for knowledge and attitude domains, respectively. The association between the demographic characteristics of respondents and knowledge, attitude, and frequency of SM was assessed using an independent sample t-test and one-way ANOVA, demonstrating satisfactory known group validity. Conclusions: The developed questionnaire proved valid and reliable for determining consumer’s knowledge, attitudes, and practices toward SM. The final tool could be valuable for future research and interventions to improve consumers’ understanding of SMP.

(1) Background: The rise of online health resources and AI has reshaped the diagnosis and treatment of disease, altering the relationship between patients and healthcare professionals and encouraging self-medication. However, questionnaires validated in the literature on self-medication seem to lack questions on the possible causes that induce such behaviors, including items that explore trust toward websites and artificial intelligence. The aim of this study is to design and validate the content of a questionnaire designed to assess self-medication in health professionals, delving into the underlying etiologies, the pharmacological categories involved and the degree of confidence placed in clinical assessments derived from AI tools. (2) Methods: Validation study of the content of an instrument consisting of two phases: 1. The content validation phase involved evaluation by a selected group of health experts, who, using a Likert-type scale, analyzed the clarity, coherence and relevance of the items. 2. Pilot study of health professionals who have indicated the practice of self-administration of medications. (3) Results: In the first phase of the study, the experts considered most of the questionnaire items to be clear, representative and consistent with the construct to be measured. In its second phase, the preliminary results of our pilot study suggest a significant trend toward self-medication among healthcare workers, along with a strong inclination to use online resources to search for health-related information. (4) Conclusions: The development of a validated instrument to measure the influence of the different causes that lead healthcare personnel to practice self-medication, guaranteeing validity and efficacy, allows us to establish strategies to reduce this growing problem.

Background: Community pharmacists are engaged in various professional activities starting from drug dispensing to promoting the well-being of patients. They dispense medications as stated in the prescription and are also licensed to prescribe over-the-counter (OTC) medications. Self-medication is widely practiced in various countries, which may lead to irrational drug use. The objectives of this study were to identify the factors associated with dispensing errors, to find ways to minimize dispensing errors, to identify patients’ reasons for self-medication, and to find the drugs commonly utilized by patients as OTC medications and the sources of their drug information. Methods: A cross-sectional survey of a convenience sample of 286 registered community pharmacists all over Tabuk was conducted using a self-administered questionnaire. Results: Physician’s unclear handwriting in the prescription was the major factor for dispensing error (2.6 out of 3) and writing the prescription clearly by the physician or using a printed form of prescription was an important factor in minimizing dispensing errors (2.91 out of 3). Previous similar complaints in the past were the main reason for self-medication (2.45 out of 3) with analgesics and antipyretics being the commonly dispensed drug groups dispensed as OTC medications (2.95 out of 3). Conclusion: Self-medication practices and dispensing errors are widespread in Tabuk. Antibiotics were dispensed as OTC medication, which may lead to more chance of irrational drug use. Writing the prescription clearly and legibly would reduce dispensing errors. It is the community pharmacists’ responsibility to increase awareness regarding the appropriate use of drugs to the public.

Abstract Introduction Self-medication was remarkably popular during the COVID-19 pandemic. In older populations, the risk of self-medication is higher. Pharmacists are well positioned to provide public health education and disease prevention. This study aims to explore the self-medication patterns and intention to seek pharmacist guidance among older adults in Macao. Methods A face-to-face cross-sectional survey was subsequently performed in March-April 2023 among older adults in Macao. The questionnaire was designed based on the Theory of Planned Behavior (TPB) framework. Multiple logistic regression was used to analyze predictors of self-medication behavior and multiple linear regression analysis to determine whether the TPB construct was the predictor of older adults’ intention to seek guidance from pharmacists. Results A total of 412 participants completed the questionnaire. The self-medication rate among older adults in Macao was 64.2%. The most commonly used types of medications were over-the-counter and traditional Chinese medicine, mainly from government anti-pandemic packages. The majority of individuals engaged in self-medication to treat COVID-19 symptoms or prevent COVID-19 infection. The prevalent reasons for self-medication were the perceived non-seriousness of the illness. 85 years old or older and university degree were significantly associated with self-medication behavior. Older adults had moderate intention to seek pharmacist guidance on medication use. The average scores (standard deviation) were 3.43 (1.10) for Attitude, 2.69 (0.99) for Subjective Norm, 3.56 (1.04) for Perceived Behavioral Control, and 3.07 (1.43) for Intention. Attitude, Subjective Norm, and Perceived Behavioral Control were all strong predictors of intention, which explained 53% of the variance in intention. In demographic factors, age was identified as a significant predictor of intentions. Conclusions Self-medication was widely practiced in Macao during the COVID-19 pandemic. To better control the risks associated with self-medication, the role of pharmacists is paramount. Enhancing the recognition and trust of pharmacists within society, modifying pharmacy management models, and strengthening pharmacists’ self-perception of their profession are all pivotal directions areas to further enhance their role.

Abstract Around 91% of migraine patients use over-the-counter medicines to treat attacks, often without further treatment or medical consultation. This therapeutic principle is established in most countries, regardless of how the healthcare system is otherwise structured or financed. Using Germany as an example, the basis for an expansion of attack therapy with rizatriptan as an over-the-counter triptan is described. To achieve the best possible tolerability and safety in the context of self-medication, the lowest possible dose should be selected to provide the most favourable tolerability and safety profile in the context of self-medication through low dosages. The lowest approved dose of rizatriptan is 5 mg. This was investigated in three randomized controlled trials with 752 patients. The results show that rizatriptan at a dose of 5 mg is more effective than the triptans naratriptan 2.5 mg, almotriptan 12.5 mg and sumatriptan 50 mg, which were previously available for self-medication in Germany. There was no significant difference in the frequency of adverse events with rizatriptan 5 mg compared to placebo. Rizatriptan 5 mg does not have a higher side effect potential than sumatriptan 50 mg, which is already exempt from the prescription requirement. The reasons given show that rizatriptan in a dose of 5 mg for the treatment of acute migraine attacks fulfils the requirements for a transfer from prescription to pharmacy-only status at least as well as sumatriptan 50 mg, naratriptan 2.5 mg and almotriptan 12.5 mg. From a clinical care perspective, it is desirable for affected patients to have other options available for self-medication. Non-responders to other substances also have a further treatment option with rizatriptan 5 mg, with the same or even better risk–benefit profile, to treat migraine attacks safely, effectively and in a tolerable manner as part of self-medication.

Introduction: self-medication is an effort made by an individual to obtain medication and use it without diagnosis, prescription, supervision, or consultation with a doctor to treat certain minor illnesses. Self-medication is self-medication without a doctor's prescription. In disease treatment, risks such as misdiagnosis, use of excessive drug doses, and long-term use can cause adverse effects on patients. Objective: to determine the description of the public's use of self-medicated pharmaceutical preparations. Methods: This type of research uses a descriptive method, namely research that includes surveys with data collection in the form of questionnaires with a total of 81 respondents. The sampling method uses Non-Probability Sampling with Purposive Sampling techniques using an open-ended questionnaire format in collecting data and recording reports. Result: results of research data collection that the description of the use of pharmaceutical preparations by self-medication in the Bung Permai Housing Community is that 81 respondents (100.00%) carry out self-medication, the source of drug information is from print and electronic media, namely 36 respondents (44.45%), the place of purchase of medicine was at the pharmacy/clinic, namely 43 respondents (53.02%), the disease suffered was fever, 23 respondents (28.40%), and the pharmaceutical preparation used was paracetamol, 27 respondents (33.33%). Conclusion: the description of self-help's use of pharmaceutical preparations in the Permai Community Housing is mostly self-medication. Therefore, there is a need for better education and supervision of using pharmaceutical preparations independently to increase understanding and safety in self-medication. It is hoped that in the future, there will be research on public knowledge and behavior regarding self-medication of pharmaceutical preparations so that changes in respondents' knowledge and behavior can be seen after being given good and correct information.

Abstract Objective To assess the impact of self-medication on the transmission dynamics of COVID-19 across different age groups, examine the interplay of vaccination and self-medication in disease spread, and identify the age group most prone to self-medication. Methods We developed an age-structured compartmentalized epidemiological model to track the early dynamics of COVID-19. Age-structured data from the Government of Gauteng, encompassing the reported cumulative number of cases and daily confirmed cases, were used to calibrate the model through a Markov Chain Monte Carlo (MCMC) framework. Subsequently, uncertainty and sensitivity analyses were conducted on the model parameters. Results We found that self-medication is predominant among the age group 15-64 (74.52%), followed by the age group 0-14 (34.02%), and then the age group 65+ (11.41%). The mean values of the basic reproduction number, the size of the first epidemic peak (the highest magnitude of the disease), and the time of the first epidemic peak (when the first highest magnitude occurs) are 4.16499, 241,715 cases, and 190.376 days, respectively. Moreover, we observed that self-medication among individuals aged 15-64 results in the highest spreading rate of COVID-19 at the onset of the outbreak and has the greatest impact on the first epidemic peak and its timing. Conclusion Studies aiming to understand the dynamics of diseases in areas prone to self-medication should account for this practice. There is a need for a campaign against COVID-19-related self-medication, specifically targeting the active population (ages 15-64).

Background Antimicrobial resistance is increasing at an alarming rate. The use of antibiotics without a prescription by a patient or other family members and their inappropriate storage have caused serious health issues as it would lead to antibiotic resistance and exposure to the risk of harmful adverse effects unnecessarily. Therefore, the study aimed to evaluate the current behaviour of antibiotic usage, storage, re-usage and misuse among the residents of Saudi Arabia. Methods This is a cross-sectional study. Our target study population was the residents of Saudi Arabia. Data were collected by an online questionnaire and analysed by SPSS. Results A total of 738 participants answered the online questionnaire from all ages, genders, nationalities, and socioeconomic backgrounds residing in different regions across the Kingdom of Saudi Arabia. 76.42% knew that an antibiotic is a chemical substance used to treat infections. The participants were questioned about when they started using antibiotics, to which 95.66% (n=706) responded after consulting a physician, 3.25% (n=24) said when they felt ill for any reason, and 1.08% (n=8) replied after first attempting herbal medicine. A total of 147 participants admitted that they store excess pills of antibiotics after being prescribed for an infection and reuse them later on for symptoms like sore throat and fever. Conclusions The results indicated that nearly half of the participants used leftover antibiotics. Participants having children in their homes significantly reuse antibiotics. However, one-third of the participants didn’t complete the antibiotics course. A large portion of the population, regardless of age, level of education, or professional background, have continued to store leftover antibiotics after an infection treatment and reuse them once they think they need them for new symptoms. This advice further revises the current measures to fill those gaps and reduce this habit.

Introduction: In Poland, the area of self-medication requires scientific and organizational evaluation. So far, no solutions sanctioning self-medication have been introduced. Therefore, the aim of this study was to recognize and analyze the practical experience of outpatient physicians regarding self-medication of their patients, as well as self-medication of children by their caregivers. Methods: This study enrolled 386 participants and used a Computer-Assisted Web Interview thatwas disseminated online from4th of July 2023 to 23rd of August 2023. The survey was addressed to outpatient healthcare physicians working in Poland. Results: In doctors' perspective the main three reasons for choosing selfmedication in Poland were: taking advice from other people - family members or friends (59.1%), finding information regarding treatment online (52.9%) and ability to self-medicate in this kind of symptoms/disease (51.6%). Among adult patients, in 72.1% of cases, an independent decision to start antibiotic therapy was made. Such a decision occurred in 39.8% of pediatric patients. Children caregivers were more likely to visit the physician immediately with symptoms than in the case of adult patients (42.2% vs. 22.1%, p < 0.001). Conclusions: Self-medication in Poland requires educational and organizational support at various levels - both social (information campaigns, school education), the healthcare system (increasing the role of medical professionals, including pharmacists), and finally in the area of legislation. Two areas seem to be particularly alarming - the use of antibiotics by adults and children and the mental health of both populations. [ABSTRACT FROM AUTHOR]

Introduction: Sexual victimization (SV) is common among college women, with approximately half of those who have experienced SV meeting criteria for posttraumatic stress disorder (PTSD) within a year. Both SV and PTSD are associated with alcohol misuse among college women, often explained by the self-medication hypothesis. Existing literature focuses on overall PTSD severity rather than potential day-to-day fluctuations in specific symptoms, which might play a crucial role in understanding alcohol misuse risk. Studies also examine only same-day or next-day associations between PTSD and drinking, neglecting the potential for longer-term changes. Methods: This study explores the short-term longitudinal stability and timelagged predictive dynamics of PTSD symptoms, affect, and drinking behavior among 174 female college heavy episodic drinkers over four weeks. Participants were categorized into three groups: those with a history of SV and PTSD (n = 77), women with SV but without PTSD (n = 59), and women without prior trauma history (n = 38) to be able to examine differences by trauma exposure, and PTSD. We compared the longitudinal stability of PTSD symptom networks, affect (arousal, positive affect, and negative affect), and drinking behavior across groups. Support vector regression determined which PTSD symptom networks and affect best predict drinking behavior at specific time lags within a 0-7 day range. Results: The PTSD group showed higher longitudinal stability for PTSD symptom networks (adjusted ps <.049) and arousal (adjusted ps <.048), but lower stability for negative affect (adjusted p =.013) and drinking behavior, including alcohol cravings (adjusted p =.019) and consumption (adjusted ps =.012), compared to the comparison groups. This suggests individuals with PTSD have more stable symptoms and arousal levels but greater fluctuations in negative affect and alcohol-related behaviors. Secondary analysis revealed PTSD symptom networks optimally predicted alcohol cravings with a three-day time lag (r=.88, p <.001) and consumption with a four-day time lag (r=.82, p <.001). Discussion: These findings challenge assumptions regarding immediate effects of PTSD and affect on drinking behavior and underscore the need for therapeutic approaches that consider longer-range effects. Future research should expand on these findings by incorporating longer-range assessments and exploring a broader range of symptom interactions. [ABSTRACT FROM AUTHOR]

Objective: Many children in sub‐Saharan Africa die from infectious diseases like malaria, pneumonia, and diarrhoea that can be prevented by early diagnosis, effective and targeted treatment. This study aimed to gain insights into case management practices by parents before they present their children to hospital. Methods: We conducted a cross‐sectional study among 332 parents attending a district hospital with their under‐fives symptomatic with fever and/or diarrhoea between November 2019 and July 2020 in rural Tanzania. Timely and targeted treatment was defined as seeking health care within 24 h of fever onset, and continued fluid intake in case of diarrhoea. Results: The main admission diagnoses were acute respiratory infections (61.8%), malaria (25.3%), diarrhoea (18.4%) and suspected sepsis (8.1%). The majority of children (91%) received treatment prior to admission, mostly antipyretics (75.6%), local herbal medicines (26.8%), and antibiotics (17.8%)—half of them without prescription from a clinician. For diarrhoea, the use of oral rehydration solution was rare (9.0%), although perceived as easily accessible and affordable. 49.4% of the parents presented their children directly to the hospital, 23.2% went to a pharmacy/drug shop and 19.3% to a primary health facility first. Malaria symptoms began mostly 3 days before the hospital visit; only 25.4% of febrile children visited any health facility within 24 h of disease onset. Prior use of local herbal medicine (AOR = 3.2; 95% CI 1.4–7.3), visiting the pharmacy (adjusted Odds Ratio [AOR] = 3.1; 95% confidence interval [CI]: 1.0–9.8), the dispensary being the nearest health facility (AOR = 3.0; 95% CI: 1.5–6.2), and financial difficulties (AOR = 2.2; 95% CI 1.1–4.5) were associated with delayed treatment. Conclusion: This study suggests that antipyretics and antibiotics dispensed at pharmacies/drug shops, as well as use of local herbal medicines, delay early diagnosis and treatment, which can be life‐threatening. Pharmacies/drug shops could be integrated as key focal points for sensitising community members on how to respond to paediatric illnesses and encourage the use of oral rehydration solutions. [ABSTRACT FROM AUTHOR]

Around 91% of migraine patients use over-the-counter medicines to treat attacks, often without further treatment or medical consultation. This therapeutic principle is established in most countries, regardless of how the healthcare system is otherwise structured or financed. Using Germany as an example, the basis for an expansion of attack therapy with rizatriptan as an over-the-counter triptan is described. To achieve the best possible tolerability and safety in the context of self-medication, the lowest possible dose should be selected to provide the most favourable tolerability and safety profile in the context of self-medication through low dosages. The lowest approved dose of rizatriptan is 5 mg. This was investigated in three randomized controlled trials with 752 patients. The results show that rizatriptan at a dose of 5 mg is more effective than the triptans naratriptan 2.5 mg, almotriptan 12.5 mg and sumatriptan 50 mg, which were previously available for self-medication in Germany. There was no significant difference in the frequency of adverse events with rizatriptan 5 mg compared to placebo. Rizatriptan 5 mg does not have a higher side effect potential than sumatriptan 50 mg, which is already exempt from the prescription requirement. The reasons given show that rizatriptan in a dose of 5 mg for the treatment of acute migraine attacks fulfils the requirements for a transfer from prescription to pharmacy-only status at least as well as sumatriptan 50 mg, naratriptan 2.5 mg and almotriptan 12.5 mg. From a clinical care perspective, it is desirable for affected patients to have other options available for self-medication. Non-responders to other substances also have a further treatment option with rizatriptan 5 mg, with the same or even better risk–benefit profile, to treat migraine attacks safely, effectively and in a tolerable manner as part of self-medication. [ABSTRACT FROM AUTHOR]

Background: Pharmacists play an essential role in self-medication by providing guidance and counselling services to consumers; hence, it is necessary to assess pharmacists' awareness and attitude towards self-medication to promote responsible self-medication practices. Objective: To develop a valid and reliable instrument to assess the knowledge and attitude of pharmacists towards self-medication practices and their role in promoting responsible self-medication. Method: A questionnaire was developed in English after a relevant literature review, which was further administered to a sample of 105 community pharmacists. The reliability of the questionnaire was assessed using the Karl–Pearson correlation and Cronbach alpha statistics. Content validity was evaluated by subject experts. The dimensional structure of items was assessed through exploratory factor analysis and confirmatory factor analysis (CFA). Key Findings: The final questionnaire comprises 27 items for knowledge and attitude with a Karl–Pearson correlation value of 0.896 and Cronbach alpha value of 0.814 (24 items), indicating good internal consistency and reproducibility. Factor analysis identified five factors: namely, (i) attitude towards providing guidance and advice to consumers to promote responsible SMP, (ii) attitude towards shared responsibility for promoting rational medicine supply and use, (iii) knowledge of the advantages and disadvantages of SMP, (iv) knowledge of the definition of self-medication, (v) attitude towards professional competency of a pharmacist as a healthcare provider. CFA results demonstrate good model fit with the value of Chi-square (184.56), CFI (0.937), RMSEA (0.054), and SRMR (0.075). Model validity measures ensure satisfactory validity and reliability. Conclusions: The findings demonstrate a valid and reliable measure for assessing the knowledge and attitude of pharmacists towards self-medication. [ABSTRACT FROM AUTHOR]

To evaluate medical students' knowledge, attitudes, and self-medication practices for acne vulgaris. An analytical cross-sectional study was conducted at Beni-Suef University's Faculty of Medicine from January 2023 to June 2023. A pre-structured questionnaire was used for the study. A total of 297 students (85.1 %) used self-medications for acne without a prescription. The total knowledge score of self-medication among the study participants was 3.81 ± 2.23. About 71.4 % knew about precautions, and 72.7 % of the participants reported that self-medication is part of self-care. There was a statistical significance between the total mean knowledge score and age (p=0.007), gender (p=0.013), and academic year (p=0.001). A significant portion of students self-medicate about acne. The total knowledge score of self-medication was to some extent not relatively high. Educational programs can be developed to increase medical students' awareness of the risks and benefits of self-medication, information on appropriate use of medications, and when to seek medical attention. [ABSTRACT FROM AUTHOR]

Introduction: Self-medication was remarkably popular during the COVID-19 pandemic. In older populations, the risk of self-medication is higher. Pharmacists are well positioned to provide public health education and disease prevention. This study aims to explore the self-medication patterns and intention to seek pharmacist guidance among older adults in Macao. Methods: A face-to-face cross-sectional survey was subsequently performed in March-April 2023 among older adults in Macao. The questionnaire was designed based on the Theory of Planned Behavior (TPB) framework. Multiple logistic regression was used to analyze predictors of self-medication behavior and multiple linear regression analysis to determine whether the TPB construct was the predictor of older adults' intention to seek guidance from pharmacists. Results: A total of 412 participants completed the questionnaire. The self-medication rate among older adults in Macao was 64.2%. The most commonly used types of medications were over-the-counter and traditional Chinese medicine, mainly from government anti-pandemic packages. The majority of individuals engaged in self-medication to treat COVID-19 symptoms or prevent COVID-19 infection. The prevalent reasons for self-medication were the perceived non-seriousness of the illness. 85 years old or older and university degree were significantly associated with self-medication behavior. Older adults had moderate intention to seek pharmacist guidance on medication use. The average scores (standard deviation) were 3.43 (1.10) for Attitude, 2.69 (0.99) for Subjective Norm, 3.56 (1.04) for Perceived Behavioral Control, and 3.07 (1.43) for Intention. Attitude, Subjective Norm, and Perceived Behavioral Control were all strong predictors of intention, which explained 53% of the variance in intention. In demographic factors, age was identified as a significant predictor of intentions. Conclusions: Self-medication was widely practiced in Macao during the COVID-19 pandemic. To better control the risks associated with self-medication, the role of pharmacists is paramount. Enhancing the recognition and trust of pharmacists within society, modifying pharmacy management models, and strengthening pharmacists' self-perception of their profession are all pivotal directions areas to further enhance their role. [ABSTRACT FROM AUTHOR]

In Brazil and around the world, self-medication is practiced for various health problems, including obesity. The use of these drugs can cause several health problems, increasing their severity when nursing professionals resort to this resource to lose weight. The objective of the study was to analyze self-medication for weight loss among nursing professionals, in addition to identifying which medications were used. 303 nursing professionals were interviewed, from 01/21/2022 to 04/24/2022, after approval by the CEP. Among the professionals who stated that they resort to this practice for weight loss purposes, 25% are nurses and 75% nursing technicians. The most cited drugs were sibutramine 24.62%, herbal medicines 21.54% and bupropion 18.46%. The results reveal a serious public health problem among these professionals, who are responsible for caring for and guiding the population, making it necessary to adopt public policies aimed at nursing care. [ABSTRACT FROM AUTHOR]

Objectives: To determine the frequency of self-medication with antibiotics and its causative factors in South Waziristan. Material and Methods: A cross-sectional study was conducted in the Tehsil Wana of South Waziristan, Khyber Pakhtunkhwa. A total of 400 participants were selected using a convenient random sampling technique. Data was collected by using a structured questionnaire after obtaining informed consent. The questionnaire included demographics, socioeconomic variables, and information on self-medication with antibiotics i.e. reason for self-medication, source of procurement, symptoms that lead to self-medication, and type of antibiotic used. Results: Of 400 subjects, 373 (93.25%) agreed to participate. The frequency of antibiotic self-medication in the study area was 84.5%. The most common reason for self-medication with antibiotics was saving money (38%). The common antibiotic used by most study participants was Amoxicillin/Clavulanic acid (42%) with respiratory tract infections as the most common indication for their usage (62%). A significant association between self-medication of antibiotics was observed with age, marital, education, and economic status of the respondents (p<0.05). No significant association of self-medication was found with gender distribution (p-value 0.438). Conclusion: The study showed a significantly high prevalence of self-medication practices with antibiotics, revealing a strong association with socio-demographic factors. A multi-sectoral approach is needed to deal with this alarming situation in this war-affected underdeveloped district of Khyber Pakhtunkhwa. [ABSTRACT FROM AUTHOR]

Introduction: Healthcare students are becoming increasingly concerned about self-medication (SM), which can have major health repercussions. It affects how future physicians make professional decisions about medications. Such a mindset has an indirect impact on providing their patients with appropriate counselling. The study was planned to investigate the attitude, determinants and different clinical aspects associated with SM of dental pain amongst medical students in Jeddah, Saudi Arabia. Materials and Methods: The present descriptive cross-sectional study was conducted exclusively on the 400 medical students from the 1st year and interns pursuing bachelor’s degrees from various medical colleges in Jeddah, Saudi Arabia. A convenient non-probability sampling technique was employed, and a pre-tested/pre-validated questionnaire was loaded on Google Forms and sent to the medical students of medicine, dentistry, pharmacy and nursing programmes. Qualitative characteristics were assessed using the Chi-square test. The significance level (P value) chosen for the various comparisons was P < 0.05. Results: The results of this study show that 65.5% of students self-medicate. It was significantly more common in women (74.9%), pharmacists (76.9%) and dental students (72.7%). Students who self-medicated less often were in the 1st and 2nd years (49.2% and 57.1%). Toothache was the most common cause for which they self-medicated (79.8%). Conclusion: The results of the present study have shed light on the fact that SM was high amongst medical students in Jeddah. The potential problems associated with self-medication should be highlighted to students to reduce the risk of inappropriate SM, which can seriously harm both students and others to whom they prescribe medication. [ABSTRACT FROM AUTHOR]

Many cannabis users report therapeutic benefits from cannabis consumption, even when not recommended by a physician. To date, few data on therapeutic users of cannabis in France are available. Using a cross-sectional survey held in 2020, we collected sociodemographic, health and substance use data from 4150 daily cannabis users in France. We used multivariable logistic regression to assess factors associated with exclusive therapeutic use of cannabis. Approximately 10% (n = 453) of the participants reported using cannabis exclusively for therapeutic purposes. Exclusive therapeutic users of cannabis differed from non-exclusive (i.e. recreational and mixed) users, especially regarding age (aOR [95%CI] = 1.01 [1.00–1.02]), employment (aOR = 0.61 [0.47–0.79]), urban area of residence (aOR = 0.75 [0.60–0.94]), physical (aOR = 2.95 [2.34–3.70]) and mental health condition (aOR = 2.63 [1.99–3.49]), mode of cannabis administration (non-smoked, aOR = 1.89 [1.22–2.95); smoked with little tobacco, aOR = 1.39 [1.09–1.76]), frequency of cannabis use (aOR = 1.04 [1.01–1.06]), home cultivation (aOR = 1.56 [1.13–2.15]), at-ridsk alcohol use (aOR = 0.68 [0.54–0.84]), and previous-month opiate use (aOR = 1.67 [1.22–2.30]). A greater understanding of the distinct profiles of regular cannabis users could inform harm reduction strategies and care access for this population. Further studies are needed to better understand the boundaries between therapeutic and recreational use. [ABSTRACT FROM AUTHOR]

Purpose: To identify self-medications used by patients as initial treatment for various eye problems and to analyze associated complications. Study Design: Cross sectional. Place and Duration of Study: Al-Khidmat teaching hospital, (University of Lahore) from October 2021 to September 2022. Method: This study included 117 patients using traditional eye medications (TEM) and over the counter (OTC) ophthalmic drugs before presenting in ophthalmic outdoor. A semi structured questionnaire was used as a tool to collect the data. All patients aged 18 years and above were directly questioned. For patients below 18 years, responses were collected from the patients themselves when possible; otherwise, the accompanying parent provided the information. Age, gender, educational status and area of residence were recorded. The symptoms compelling the use of TEM/OTC or both, the source and type of medication, diagnosis and any complications that resulted due to self-medication were documented. Complete ocular examination was done. MS Excel was used to record and analyze data. Results: There were 48% males and 52% females. Rosewater was the most frequently used TEM by 54.7%. Steroids-antibiotic combination eyedrops/ointments were used by 31.6%. Symptoms for which self-medication was done, were redness (64.1%), watering (35.9%), itching (32.5%) and discharge (26.5%). Symptoms did not improve in 54.7%, 26.5% required ophthalmic consultation and only 18.8% had temporary relief. Twelve percent developed complications. Conclusion: Self-medication with TEM or OTC drugs should be discouraged as these can cause detrimental effects on eyes. [ABSTRACT FROM AUTHOR]

Self-medication is a global public health problem, particularly among University students at the beginning of their careers. This study aims to determine awareness and attitude toward self-medication practices among Foundation Year - Health Science Students at PNU in Riyadh, Saudi Arabia. We conducted a cross-sectional survey using convenient sampling techniques to identify study participants. After obtaining written consent, we emailed them an online questionnaire that included information on sociodemographics, knowledge, students' awareness of self-medication, and reasons for self-medication. We computed means and standard deviations to report continuous variables, frequencies, and proportions to report categorical variables, which were analyzed by Excel software. The mean age and body mass index were 19.17 ±2.23 and 22.91±4.25, respectively. About 75% of the students mentioned they had used selfmedication in the past. One-third of respondents mentioned that self-medication can cause harm, and 58.8% mentioned that selfmedication can cause harm sometimes. The most common resource for self-medication was pharmacy stores, followed by families and friends. The most common reasons to self-medicate were multiple, including economical, saving time, convenience, quick relief of the symptoms, no availability of a medical service, and minor illness. The reasons reported by students were multiple, including common cold, headache, fever, and dysmenorrhea, followed by insomnia. The burden of self-medication is alarming among university students, with about three-fourths of them reporting using drugs to self-medicate. These findings can help policymakers and university administrators raise awareness among students about the negative impact of medications on their lives. [ABSTRACT FROM AUTHOR]

Objective: To assess the impact of self-medication on the transmission dynamics of COVID-19 across different age groups, examine the interplay of vaccination and self-medication in disease spread, and identify the age group most prone to self-medication. Methods: We developed an age-structured compartmentalized epidemiological model to track the early dynamics of COVID-19. Age-structured data from the Government of Gauteng, encompassing the reported cumulative number of cases and daily confirmed cases, were used to calibrate the model through a Markov Chain Monte Carlo (MCMC) framework. Subsequently, uncertainty and sensitivity analyses were conducted on the model parameters. Results: We found that self-medication is predominant among the age group 15-64 (74.52%), followed by the age group 0-14 (34.02%), and then the age group 65+ (11.41%). The mean values of the basic reproduction number, the size of the first epidemic peak (the highest magnitude of the disease), and the time of the first epidemic peak (when the first highest magnitude occurs) are 4.16499, 241,715 cases, and 190.376 days, respectively. Moreover, we observed that self-medication among individuals aged 15-64 results in the highest spreading rate of COVID-19 at the onset of the outbreak and has the greatest impact on the first epidemic peak and its timing. Conclusion: Studies aiming to understand the dynamics of diseases in areas prone to self-medication should account for this practice. There is a need for a campaign against COVID-19-related self-medication, specifically targeting the active population (ages 15-64). [ABSTRACT FROM AUTHOR]

Background: Knowledge of self-medication is associated with engaging in self-medication. Choosing the wrong common cold medication not only fails to deliver the best results but also leads to higher treatment expenses. Based on previous research in 2023, it was reported that 19.88% student in Yogyakarta had low knowledge about common cold self-medication. Objective: This service activity aims to increase teenagers' knowledge about rational self-medication for common cold. Method: The activity involved directly educating partners about rational self-medication for the common cold through the use of posters and leaflets, followed by their understanding with pre-tests and post-tests. Results: Following schooling, partners’ knowledge increased. Conclusion: Education can raise public awareness of rational self-medication for the common cold, allowing people to make more informed decision when taking medications in their regular self-medication practices. [ABSTRACT FROM AUTHOR]

Medicine-sharing behavior can be divided into two groups: borrowing medicine from someone else and lending medicine to someone else without consulting a doctor or a pharmacist. There are many reasons for the behavior that leads individuals to share their prescription medicines. However, there is a lack in the literature to investigate individuals' medicine-sharing behavior and related antecedents and outcomes of this behavior. The main objective of this study is to model individuals' prescription medicine borrowing (PMB) behavior via the structural equation model based on the Theory of Planned Behavior (TPB). A measurement tool was developed according to TPB. Exploratory factor analysis was conducted to determine subfactors of PBM behavior. In the second step, confirmatory factor analysis (CFA) was conducted to confirm whether there is a relationship between the observed variables and their underlying latent constructs. Finally, a structural equation model was conducted to specify the relationships between latent variables. IBM Statistical Package for Social Sciences (IBM SPSS Software) version 22 and LISREL 8.80 were used for data analysis. Study findings reveal that the participants' attitudes and intentions towards PMB are low, and the rate of exhibiting this behavior is also low. In the proposed prescription medicine borrowing behavior model, the positive effect of attitude towards PMB, perceived behavioral control related PMB, and subjective norm about PMB on intention towards PMB were found statistically significant. Intention towards PMB has been found to have a positive statistically significant effect on PMB behavior. Based on the results of this study, it is possible to say that TPB is an appropriate theory for modeling PMB. Thus, this model will shed light on healthcare providers and policy-makers to avoid individuals from the adverse effects of PMB behavior. • The Theory of Planned Behavior was applied to individuals' prescription medicine borrowing behavior. • A prescription medicine borrowing scale was developed and validated. • Respondents' prescription medicine borrowing intention was mainly affected by how they see this behavior easily. • Respondents' prescription medicine borrowing intention positively affects their behavior. [ABSTRACT FROM AUTHOR]

Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to manage pain, fever, and inflammation. Although most are usually classified as prescription-only medicines, in many countries they are frequently purchased for self-medication purposes. This study explores NSAID-usage patterns in Kosovo, aiming for a safer and more effective medicinal use. The study employed a dual approach to collect data. First, NSAID sales were analyzed in a convenience sample of ten community pharmacies across diverse regions in Kosovo in 2023. Second, data on NSAID-usage patterns and patient awareness were systematically gathered from 410 patients during routine pharmacist–patient interactions. The four most commonly purchased NSAIDs according to sales analysis were diclofenac (33.1%), ketoprofen (27.6%), ibuprofen (17.0%) and nimesulide (12.7%). A significant 74.8% of NSAIDs were bought without prescriptions, particularly among younger adults (20–39 years), who accounted for 82.8% of such purchases. The predominant reason for NSAID use was headache (43.8%). Although many of the patients suffered from occasional (33.7%) or frequent (12.6%) stomachaches and took acid-lowering medicines, the majority (85.9%) could not recall any NSAID adverse reactions. This study exposes widespread self-medication and a significant lack of awareness regarding potential risks of NSAIDs, particularly among young adults. To address these issues, it is critical to improve dispensing practices through increased pharmacist awareness and stricter law enforcement. [ABSTRACT FROM AUTHOR]

The shift of proton pump inhibitors (PPIs) from prescription to nonprescription (nonRx) status in Canada has altered pharmacist treatment options for heartburn. This report examines pharmacist approaches to therapy based on case severity; pharmacist confidence and consult duration were also explored. A 2022 online survey gathered data from Ontario and Québec pharmacists regarding their therapeutic approaches for two hypothetical heartburn cases. A total of 715 pharmacists participated, with most having 1–10 years of experience. In Ontario, common choices for the milder case included a solo histamine-2 receptor antagonist (H2RA) (21.2%), combination H2RA + antacid (29.4%), and nonRx PPI (22.3%). For the more severe case, common choices for Québec were switches to nonRx H2RA (22.1%), combination H2RA + antacid (13.4%), a nonRx PPI (24.9%), or prescription PPI (22.5%). Pharmacists often recommended switching medications or referring patients with recurring symptoms after seven days. The approaches varied significantly between cases and provinces. The Ontario pharmacists favoured a combination H2RA + antacid for the milder case, while the Québec pharmacists preferred a solo H2RA. For the more severe case, both groups often chose nonRx H2RA followed by nonRx PPI. Despite the differences, the pharmacists demonstrated confidence in managing these situations. These findings highlight potential debates regarding optimal therapeutic approaches and the impact of drug scheduling on patient care. [ABSTRACT FROM AUTHOR]

Dysmenorrhea is a known phenomenon and not just recently, and investigations conducted recently have shown that female adolescents are very susceptible to this condition. Our goal is to determine the prevalence of dysmenorrhea in Tunisia, its risk factors, its impact on truancy rates, and the therapeutic attitudes of girls attending high school about this illness using an epidemiological survey. This eight-month study, which spans from October 2022 to May 2023, focuses on 160 high school girls between the ages of 13 and 21. It is a transversal descriptive study. The required data is gathered through the distribution of a self-administered questionnaire. The mean age of female adolescent participants is 16.44 years and 68 % of them reported dysmenorrhea. The most common symptoms of the pain were headaches (40.0 %). There is a notable prevalence of absenteeism during the menstrual cycle. There seems to be a trend toward self-medication. In Tunisia, primary dysmenorrhea is a common cause of school absenteeism among female adolescents. Girls' attitudes toward dysmenorrhea indicate a lack of knowledge, which is why it is crucial for midwives and physicians to educate teenage girls about the condition. [ABSTRACT FROM AUTHOR]

Background: The practice of self-medication (SM) is common worldwide and is an important component of medical self-care. However, improper practice can be dangerous. This study aimed to estimate the prevalence of SM and the factors associated with it among Bangladeshi adults. Methods: A cross-sectional survey was conducted between April and June 2021 among Bangladeshi adults (aged > 19 years) using convenient sampling. A total of 1320 subjects were collected through face-to-face interviews using a standardized questionnaire. Multivariable logistic regression analysis was used to identify factors associated with the practice of SM. Results: Overall, 41% of adults in our survey reported SMP. The most common illnesses that prompted SM were common cold/flu (66.4%), gastric problems (65%), and headache (64.4%). The most frequent reasons for SM were to get better-perceived quality of care (30.6%), perceiving SM without side effects (23.3%), and saving time with effectiveness (14.56%). Potential risk factors included 10 years (AOR = 1.91; 95% CI: 1.04–3.50) and >12 years of schooling (AOR = 5.03; 95% CI: 2.27–11.15), being a businessman (AOR = 4.64; 95% CI: 1.74–12.37), having ≤6 family members (AOR = 2.13; 95% CI: 1.40–3.24), being a member of a social group (AOR = 1.53; 95% CI: 1.10–2.12), a health status check after every six months (AOR = 1.52; 95% CI: 1.08–2.13), and current ill-health (AOR = 1.41; 95% CI: 1.06–1.87). Protective factors identified included ≤30 years of age (AOR = 0.40; 95% CI: 0.17–0.93), and practice of modern (AOR = 0.39; 95% CI: 0.22–0.69) and herbal (AOR = 0.45; 95% CI: 0.21–0.97) treatment modality. Conclusion: More than one-third of the study participants reported practicing SM. Increasing the community's awareness of the adverse outcomes of SM and not just the average experience might sway individuals away from SM, and implementing strict jurisdiction could be a way to minimize inappropriate SM. [ABSTRACT FROM AUTHOR]