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2. Injectable, Drug-Eluting Nanocrystals Prevent Fibrosis and Stricture Formation In Vivo

Author

Li, Ling, Shapiro, Rachel L., Joo, Min Kyung, Josyula, Aditya, Hsueh, Henry T., Gutierrez, Olaya Brewer, Halpert, Gilad, Akshintala, Venkata, Chen, Haiming, Curtis, Samuel, Better, Marina, Davison, Charlotte, Hu, Haijie, Almario, Jose Antonio Navarro, Steinway, Steven N., Hunt, Kelton, Del Sesto, Rico E., Izzi, Jessica, Salimian, Kevan J., Ensign, Laura M., and Selaru, Florin M.

Published
2023
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7. Challenges in IBD Research 2024: Novel Technologies

Author

Prasad, Shalini, primary, Cross, Raymond K, additional, Monroe, Mary Beth, additional, Dolinger, Michael T, additional, Motte, Rachel, additional, Hong, Sungmo, additional, Stidham, Ryan W, additional, Kumar, Narendra, additional, Levine, Deborah, additional, Larijani, Anthony, additional, Simone, Ashley, additional, Chachu, Karen A, additional, Wyborski, Russell, additional, Heller, Caren A, additional, Moss, Alan C, additional, Schwerbrock, Nicole M J, additional, and Selaru, Florin M, additional

Published
2024
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17. Antibody Kinetics after Three Doses of SARS-CoV-2 mRNA Vaccination in Patients with Inflammatory Bowel Disease

Author

Tsipotis, Evangelos, primary, Maremanda, Ankith, additional, Zeiser, Laura Bowles, additional, Connolly, Caoilfhionn, additional, Sharma, Sowmya, additional, Dudley-Brown, Sharon, additional, Frey, Sarah, additional, Lazarev, Mark, additional, Melia, Joanna M., additional, Parian, Alyssa M., additional, Segev, Dorry L., additional, Truta, Brindusa, additional, Yu, Huimin, additional, Werbel, William A., additional, and Selaru, Florin M., additional

Published
2023
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21. PSMA-Targeted PET Radiotracer [18F]DCFPyL as an Imaging Biomarker in Inflammatory Bowel Disease.

Author

Ismail, Mohamed Saleh, Peters, Diane E, Rowe, Steven P, Salavati, Ali, Sharma, Sowmya, Anders, Robert A, Pomper, Martin, Slusher, Barbara S, and Selaru, Florin M

Subjects
INFLAMMATORY bowel diseases, POSITRON emission tomography, BIOMARKERS, RADIOACTIVE tracers, COMPUTED tomography
Abstract

Background: Prostate-specific membrane antigen (PSMA) is highly and specifically upregulated in active-inflamed mucosa of patients with inflammatory bowel disease (IBD). We hypothesized that this upregulation would be detectable using a PSMA-targeted positron emission tomography/computed tomography (PET/CT) imaging agent, [18F]DCFPyL, enabling non-invasive visualization of inflammation. A noninvasive means of detecting active inflammation would have high clinical value in localization and management of IBD.Study: We performed [18F]DCFPyL imaging in three IBD patients with active disease. Abnormally increased gastrointestinal [18F]DCFPyL uptake was observed in areas with endoscopic, histologic, and immunohistochemical inflammation, demonstrating partial overlap of segments of bowel with abnormal [18F]DCFPyL uptake and active inflammation.Conclusion: This study demonstrates that PSMA-targeted [18F]DCFPyL PET can effectively detect regions of inflamed mucosa in patients with IBD, suggesting its utility as a non-invasive imaging agent to assess location, extent, and disease activity in IBD. [ABSTRACT FROM AUTHOR]

Published
2023
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24. Supplementary Table 1 from A Multicenter, Double-Blinded Validation Study of Methylation Biomarkers for Progression Prediction in Barrett's Esophagus

Author

Jin, Zhe, primary, Cheng, Yulan, primary, Gu, Wen, primary, Zheng, Yingye, primary, Sato, Fumiaki, primary, Mori, Yuriko, primary, Olaru, Alexandru V., primary, Paun, Bogdan C., primary, Yang, Jian, primary, Kan, Takatsugu, primary, Ito, Tetsuo, primary, Hamilton, James P., primary, Selaru, Florin M., primary, Agarwal, Rachana, primary, David, Stefan, primary, Abraham, John M., primary, Wolfsen, Herbert C., primary, Wallace, Michael B., primary, Shaheen, Nicholas J., primary, Washington, Kay, primary, Wang, Jean, primary, Canto, Marcia Irene, primary, Bhattacharyya, Achyut, primary, Nelson, Mark A., primary, Wagner, Paul D., primary, Romero, Yvonne, primary, Wang, Kenneth K., primary, Feng, Ziding, primary, Sampliner, Richard E., primary, and Meltzer, Stephen J., primary

Published
2023
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25. Supplementary Table 3 from A Multicenter, Double-Blinded Validation Study of Methylation Biomarkers for Progression Prediction in Barrett's Esophagus

Author

Jin, Zhe, primary, Cheng, Yulan, primary, Gu, Wen, primary, Zheng, Yingye, primary, Sato, Fumiaki, primary, Mori, Yuriko, primary, Olaru, Alexandru V., primary, Paun, Bogdan C., primary, Yang, Jian, primary, Kan, Takatsugu, primary, Ito, Tetsuo, primary, Hamilton, James P., primary, Selaru, Florin M., primary, Agarwal, Rachana, primary, David, Stefan, primary, Abraham, John M., primary, Wolfsen, Herbert C., primary, Wallace, Michael B., primary, Shaheen, Nicholas J., primary, Washington, Kay, primary, Wang, Jean, primary, Canto, Marcia Irene, primary, Bhattacharyya, Achyut, primary, Nelson, Mark A., primary, Wagner, Paul D., primary, Romero, Yvonne, primary, Wang, Kenneth K., primary, Feng, Ziding, primary, Sampliner, Richard E., primary, and Meltzer, Stephen J., primary

Published
2023
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26. Supplementary Figure 2 from A Multicenter, Double-Blinded Validation Study of Methylation Biomarkers for Progression Prediction in Barrett's Esophagus

Author

Jin, Zhe, primary, Cheng, Yulan, primary, Gu, Wen, primary, Zheng, Yingye, primary, Sato, Fumiaki, primary, Mori, Yuriko, primary, Olaru, Alexandru V., primary, Paun, Bogdan C., primary, Yang, Jian, primary, Kan, Takatsugu, primary, Ito, Tetsuo, primary, Hamilton, James P., primary, Selaru, Florin M., primary, Agarwal, Rachana, primary, David, Stefan, primary, Abraham, John M., primary, Wolfsen, Herbert C., primary, Wallace, Michael B., primary, Shaheen, Nicholas J., primary, Washington, Kay, primary, Wang, Jean, primary, Canto, Marcia Irene, primary, Bhattacharyya, Achyut, primary, Nelson, Mark A., primary, Wagner, Paul D., primary, Romero, Yvonne, primary, Wang, Kenneth K., primary, Feng, Ziding, primary, Sampliner, Richard E., primary, and Meltzer, Stephen J., primary

Published
2023
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27. Supplementary Figure Legends 1-2 from A Multicenter, Double-Blinded Validation Study of Methylation Biomarkers for Progression Prediction in Barrett's Esophagus

Author

Jin, Zhe, primary, Cheng, Yulan, primary, Gu, Wen, primary, Zheng, Yingye, primary, Sato, Fumiaki, primary, Mori, Yuriko, primary, Olaru, Alexandru V., primary, Paun, Bogdan C., primary, Yang, Jian, primary, Kan, Takatsugu, primary, Ito, Tetsuo, primary, Hamilton, James P., primary, Selaru, Florin M., primary, Agarwal, Rachana, primary, David, Stefan, primary, Abraham, John M., primary, Wolfsen, Herbert C., primary, Wallace, Michael B., primary, Shaheen, Nicholas J., primary, Washington, Kay, primary, Wang, Jean, primary, Canto, Marcia Irene, primary, Bhattacharyya, Achyut, primary, Nelson, Mark A., primary, Wagner, Paul D., primary, Romero, Yvonne, primary, Wang, Kenneth K., primary, Feng, Ziding, primary, Sampliner, Richard E., primary, and Meltzer, Stephen J., primary

Published
2023
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28. Supplementary Table 2 from A Multicenter, Double-Blinded Validation Study of Methylation Biomarkers for Progression Prediction in Barrett's Esophagus

Author

Jin, Zhe, primary, Cheng, Yulan, primary, Gu, Wen, primary, Zheng, Yingye, primary, Sato, Fumiaki, primary, Mori, Yuriko, primary, Olaru, Alexandru V., primary, Paun, Bogdan C., primary, Yang, Jian, primary, Kan, Takatsugu, primary, Ito, Tetsuo, primary, Hamilton, James P., primary, Selaru, Florin M., primary, Agarwal, Rachana, primary, David, Stefan, primary, Abraham, John M., primary, Wolfsen, Herbert C., primary, Wallace, Michael B., primary, Shaheen, Nicholas J., primary, Washington, Kay, primary, Wang, Jean, primary, Canto, Marcia Irene, primary, Bhattacharyya, Achyut, primary, Nelson, Mark A., primary, Wagner, Paul D., primary, Romero, Yvonne, primary, Wang, Kenneth K., primary, Feng, Ziding, primary, Sampliner, Richard E., primary, and Meltzer, Stephen J., primary

Published
2023
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29. Supplementary Methods section from Identification of Genes Uniquely Involved in Frequent Microsatellite Instability Colon Carcinogenesis by Expression Profiling Combined with Epigenetic Scanning

Author

Mori, Yuriko, primary, Yin, Jing, primary, Sato, Fumiaki, primary, Sterian, Anca, primary, Simms, Lisa A., primary, Selaru, Florin M., primary, Schulmann, Karsten, primary, Xu, Yan, primary, Olaru, Andreea, primary, Wang, Suna, primary, Deacu, Elena, primary, Abraham, John M., primary, Young, Joanne, primary, Leggett, Barbara A., primary, and Meltzer, Stephen J., primary

Published
2023
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30. Data from A Multicenter, Double-Blinded Validation Study of Methylation Biomarkers for Progression Prediction in Barrett's Esophagus

Author

Jin, Zhe, primary, Cheng, Yulan, primary, Gu, Wen, primary, Zheng, Yingye, primary, Sato, Fumiaki, primary, Mori, Yuriko, primary, Olaru, Alexandru V., primary, Paun, Bogdan C., primary, Yang, Jian, primary, Kan, Takatsugu, primary, Ito, Tetsuo, primary, Hamilton, James P., primary, Selaru, Florin M., primary, Agarwal, Rachana, primary, David, Stefan, primary, Abraham, John M., primary, Wolfsen, Herbert C., primary, Wallace, Michael B., primary, Shaheen, Nicholas J., primary, Washington, Kay, primary, Wang, Jean, primary, Canto, Marcia Irene, primary, Bhattacharyya, Achyut, primary, Nelson, Mark A., primary, Wagner, Paul D., primary, Romero, Yvonne, primary, Wang, Kenneth K., primary, Feng, Ziding, primary, Sampliner, Richard E., primary, and Meltzer, Stephen J., primary

Published
2023
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31. Supplementary Figure 1 from A Multicenter, Double-Blinded Validation Study of Methylation Biomarkers for Progression Prediction in Barrett's Esophagus

Author

Jin, Zhe, primary, Cheng, Yulan, primary, Gu, Wen, primary, Zheng, Yingye, primary, Sato, Fumiaki, primary, Mori, Yuriko, primary, Olaru, Alexandru V., primary, Paun, Bogdan C., primary, Yang, Jian, primary, Kan, Takatsugu, primary, Ito, Tetsuo, primary, Hamilton, James P., primary, Selaru, Florin M., primary, Agarwal, Rachana, primary, David, Stefan, primary, Abraham, John M., primary, Wolfsen, Herbert C., primary, Wallace, Michael B., primary, Shaheen, Nicholas J., primary, Washington, Kay, primary, Wang, Jean, primary, Canto, Marcia Irene, primary, Bhattacharyya, Achyut, primary, Nelson, Mark A., primary, Wagner, Paul D., primary, Romero, Yvonne, primary, Wang, Kenneth K., primary, Feng, Ziding, primary, Sampliner, Richard E., primary, and Meltzer, Stephen J., primary

Published
2023
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32. Supplementary Table 1 from Identification of Genes Uniquely Involved in Frequent Microsatellite Instability Colon Carcinogenesis by Expression Profiling Combined with Epigenetic Scanning

Author

Mori, Yuriko, primary, Yin, Jing, primary, Sato, Fumiaki, primary, Sterian, Anca, primary, Simms, Lisa A., primary, Selaru, Florin M., primary, Schulmann, Karsten, primary, Xu, Yan, primary, Olaru, Andreea, primary, Wang, Suna, primary, Deacu, Elena, primary, Abraham, John M., primary, Young, Joanne, primary, Leggett, Barbara A., primary, and Meltzer, Stephen J., primary

Published
2023
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33. Supplementary Table 2 from Identification of Genes Uniquely Involved in Frequent Microsatellite Instability Colon Carcinogenesis by Expression Profiling Combined with Epigenetic Scanning

Author

Mori, Yuriko, primary, Yin, Jing, primary, Sato, Fumiaki, primary, Sterian, Anca, primary, Simms, Lisa A., primary, Selaru, Florin M., primary, Schulmann, Karsten, primary, Xu, Yan, primary, Olaru, Andreea, primary, Wang, Suna, primary, Deacu, Elena, primary, Abraham, John M., primary, Young, Joanne, primary, Leggett, Barbara A., primary, and Meltzer, Stephen J., primary

Published
2023
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34. Data from Identification of Genes Uniquely Involved in Frequent Microsatellite Instability Colon Carcinogenesis by Expression Profiling Combined with Epigenetic Scanning

Author

Mori, Yuriko, primary, Yin, Jing, primary, Sato, Fumiaki, primary, Sterian, Anca, primary, Simms, Lisa A., primary, Selaru, Florin M., primary, Schulmann, Karsten, primary, Xu, Yan, primary, Olaru, Andreea, primary, Wang, Suna, primary, Deacu, Elena, primary, Abraham, John M., primary, Young, Joanne, primary, Leggett, Barbara A., primary, and Meltzer, Stephen J., primary

Published
2023
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35. Supplementary Table 4 from A Multicenter, Double-Blinded Validation Study of Methylation Biomarkers for Progression Prediction in Barrett's Esophagus

Author

Jin, Zhe, primary, Cheng, Yulan, primary, Gu, Wen, primary, Zheng, Yingye, primary, Sato, Fumiaki, primary, Mori, Yuriko, primary, Olaru, Alexandru V., primary, Paun, Bogdan C., primary, Yang, Jian, primary, Kan, Takatsugu, primary, Ito, Tetsuo, primary, Hamilton, James P., primary, Selaru, Florin M., primary, Agarwal, Rachana, primary, David, Stefan, primary, Abraham, John M., primary, Wolfsen, Herbert C., primary, Wallace, Michael B., primary, Shaheen, Nicholas J., primary, Washington, Kay, primary, Wang, Jean, primary, Canto, Marcia Irene, primary, Bhattacharyya, Achyut, primary, Nelson, Mark A., primary, Wagner, Paul D., primary, Romero, Yvonne, primary, Wang, Kenneth K., primary, Feng, Ziding, primary, Sampliner, Richard E., primary, and Meltzer, Stephen J., primary

Published
2023
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36. PSMA-Targeted PET Radiotracer [18F]DCFPyL as an Imaging Biomarker in Inflammatory Bowel Disease

Author

Ismail,Mohamed Saleh, Peters,Diane E, Rowe,Steven P, Salavati,Ali, Sharma,Sowmya, Anders,Robert, Pomper,Martin, Slusher,Barbara S, Selaru,Florin M, Ismail,Mohamed Saleh, Peters,Diane E, Rowe,Steven P, Salavati,Ali, Sharma,Sowmya, Anders,Robert, Pomper,Martin, Slusher,Barbara S, and Selaru,Florin M

Abstract

Mohamed Saleh Ismail,1,* Diane E Peters,2,3,* Steven P Rowe,4,5,* Ali Salavati,6 Sowmya Sharma,1 Robert A Anders,7 Martin Pomper,2,4,5,* Barbara S Slusher,2,3,8,* Florin M Selaru1,5,* 1Division of Gastroenterology, Johns Hopkins Medical Institutions, Baltimore, MD, USA; 2Department of Pharmacology and Molecular Sciences, Johns Hopkins Medical Institutions, Baltimore, MD, USA; 3Johns Hopkins Drug Discovery, Baltimore, MD, USA; 4Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, USA; 5The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, MD, USA; 6Ahmanson Translational Theranostics Division, Department of Molecular and Medical Pharmacology, University of California Los Angeles (UCLA), Los Angeles, CA, USA; 7The Bloomberg-Kimmel Institute for Cancer Immunotherapy, Johns Hopkins Medical Institutions, Baltimore, MD, USA; 8Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, MD, USA*These authors contributed equally to this workCorrespondence: Florin M Selaru; Barbara S Slusher, Email fselaru1@jhmi.edu; bslusher@jhmi.eduBackground: Prostate-specific membrane antigen (PSMA) is highly and specifically upregulated in active-inflamed mucosa of patients with inflammatory bowel disease (IBD). We hypothesized that this upregulation would be detectable using a PSMA-targeted positron emission tomography/computed tomography (PET/CT) imaging agent, [18F]DCFPyL, enabling non-invasive visualization of inflammation. A noninvasive means of detecting active inflammation would have high clinical value in localization and management of IBD.Study: We performed [18F]DCFPyL imaging in three IBD patients with active disease. Abnormally increased gastrointestinal [18F]DCFPyL uptake was observed in areas with endoscopic, histologic, and immunohistochemical inflammation, demonstrating partial overlap of segments of

Published
2023

37. Non-Viral Gene Delivery to Hepatocellular Carcinoma via Intra-Arterial Injection

Author

Vaughan,Hannah J, Zamboni,Camila G, Luly,Kathryn M, Li,Ling, Gabrielson,Kathleen L, Hassan,Laboni F, Radant,Nicholas P, Bhardwaj,Pranshu, Selaru,Florin M, Pomper,Martin G, Green,Jordan J, Vaughan,Hannah J, Zamboni,Camila G, Luly,Kathryn M, Li,Ling, Gabrielson,Kathleen L, Hassan,Laboni F, Radant,Nicholas P, Bhardwaj,Pranshu, Selaru,Florin M, Pomper,Martin G, and Green,Jordan J

Abstract

Hannah J Vaughan,1,2 Camila G Zamboni,1,2 Kathryn M Luly,1,2 Ling Li,3 Kathleen L Gabrielson,4 Laboni F Hassan,1,2 Nicholas P Radant,1,2 Pranshu Bhardwaj,1,2 Florin M Selaru,3 Martin G Pomper,1,5,6 Jordan J Green1,2,6,7 1Department of Biomedical Engineering and the Institute for NanoBioTechnology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; 2Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA; 3Division of Gastroenterology and Hepatology, Department of Medicine and Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, MD, USA; 4Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; 5Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, USA; 6Department of Materials Science and Engineering and the Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA; 7Departments of Neurosurgery, Oncology, Ophthalmology, and Bloomberg~Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USACorrespondence: Jordan J Green, Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 400 N Broadway, Smith 5017, Baltimore, MD, 21231, USA, Tel +1 410 614-9113, Email green@jhu.eduPurpose: Hepatocellular carcinoma (HCC) has limited treatment options, and modest survival after systemic chemotherapy or procedures such as transarterial chemoembolization (TACE). There is therefore a need to develop targeted therapies to address HCC. Gene therapies hold immense promise in treating a variety of diseases, including HCC, though delivery remains a critical hurdle. This study investigated a new approach of local delivery of polymeric nanoparticles (NPs) via intra-arterial injection for targeted local gene delivery to HCC tumors in an orthotopic rat li

Published
2023

38. Criteria for preclinical models of cholangiocarcinoma:scientific and medical relevance

Author

Calvisi, Diego F., Boulter, Luke, Vaquero, Javier, Saborowski, Anna, Fabris, Luca, Rodrigues, Pedro M., Coulouarn, Cédric, Castro, Rui E., Segatto, Oreste, Raggi, Chiara, van der Laan, Luc J.W., Carpino, Guido, Goeppert, Benjamin, Roessler, Stephanie, Kendall, Timothy J., Evert, Matthias, Gonzalez-Sanchez, Ester, Valle, Juan W., Vogel, Arndt, Bridgewater, John, Borad, Mitesh J., Gores, Gregory J., Roberts, Lewis, Marin, Jose J.G., Andersen, Jesper B., Alvaro, Domenico, Forner, Alejandro, Banales, Jesus M., Cardinale, Vincenzo, Macias, Rocio I.R., Vicent, Silve, Chen, Xin, Braconi, Chiara, Verstegen, Monique M.A., Fouassier, Laura, Scheiter, Alexander, Selaru, Florin M., Evert, Katja, Utpatel, Kirsten, Broutier, Laura, Cadamuro, Massimiliano, Huch, Meritxell, Goldin, Robert, Gradilone, Sergio A., Saito, Yoshimasa, Calvisi, Diego F., Boulter, Luke, Vaquero, Javier, Saborowski, Anna, Fabris, Luca, Rodrigues, Pedro M., Coulouarn, Cédric, Castro, Rui E., Segatto, Oreste, Raggi, Chiara, van der Laan, Luc J.W., Carpino, Guido, Goeppert, Benjamin, Roessler, Stephanie, Kendall, Timothy J., Evert, Matthias, Gonzalez-Sanchez, Ester, Valle, Juan W., Vogel, Arndt, Bridgewater, John, Borad, Mitesh J., Gores, Gregory J., Roberts, Lewis, Marin, Jose J.G., Andersen, Jesper B., Alvaro, Domenico, Forner, Alejandro, Banales, Jesus M., Cardinale, Vincenzo, Macias, Rocio I.R., Vicent, Silve, Chen, Xin, Braconi, Chiara, Verstegen, Monique M.A., Fouassier, Laura, Scheiter, Alexander, Selaru, Florin M., Evert, Katja, Utpatel, Kirsten, Broutier, Laura, Cadamuro, Massimiliano, Huch, Meritxell, Goldin, Robert, Gradilone, Sergio A., and Saito, Yoshimasa

Abstract

Cholangiocarcinoma (CCA) is a rare malignancy that develops at any point along the biliary tree. CCA has a poor prognosis, its clinical management remains challenging, and effective treatments are lacking. Therefore, preclinical research is of pivotal importance and necessary to acquire a deeper understanding of CCA and improve therapeutic outcomes. Preclinical research involves developing and managing complementary experimental models, from in vitro assays using primary cells or cell lines cultured in 2D or 3D to in vivo models with engrafted material, chemically induced CCA or genetically engineered models. All are valuable tools with well-defined advantages and limitations. The choice of a preclinical model is guided by the question(s) to be addressed; ideally, results should be recapitulated in independent approaches. In this Consensus Statement, a task force of 45 experts in CCA molecular and cellular biology and clinicians, including pathologists, from ten countries provides recommendations on the minimal criteria for preclinical models to provide a uniform approach. These recommendations are based on two rounds of questionnaires completed by 35 (first round) and 45 (second round) experts to reach a consensus with 13 statements. An agreement was defined when at least 90% of the participants voting anonymously agreed with a statement. The ultimate goal was to transfer basic laboratory research to the clinics through increased disease understanding and to develop clinical biomarkers and innovative therapies for patients with CCA.

Published
2023

39. Emerging therapeutics for the management of intestinal fibrosis and strictures

Author

Neupane, Yub Raj, Yogananda, Thanuja Marasarakottige, Rompicharla, Sri Vishnu Kiran, Selaru, Florin M., and Ensign, Laura M.

Abstract

Chronic intestinal inflammation in patients with inflammatory bowel disease (IBD) can lead to the development of fibrosis and the formation of strictures. Endoscopic balloon dilation and surgical resection are currently the only available treatments for fibrotic strictures. However, both strategies are associated with potential complications and high rates of stricture recurrence, necessitating additional procedures and/or multiple surgical resections. IBD therapeutic modalities aimed at inflammation, including anti-inflammatory agents, such as corticosteroids, biologics and small molecules, have shown limited efficacy in altering the natural history of strictures, ameliorating fibrosis progression, or preventing recurrences. New and innovative therapeutic approaches targeted at fibrosis are urgently needed. Herein, we provide an overview of emerging therapeutics, including novel drug delivery systems, for the management of intestinal fibrosis and strictures.

Published
2024
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40. Current and emerging therapeutic strategies for perianal fistula in Crohn’s disease patients

Author

Ding, Kailei, Kong, Jiayuan, Li, Ling, Selaru, Florin M., Parian, Alyssa, and Mao, Hai-Quan

Abstract

The long-term remission rates achieved with current treatment options for Crohn’s disease with perianal fistula (CD-PAF)—including antibiotics, biologics, immunomodulators, and Janus kinase inhibitors, often combined with advanced surgical interventions—remain unsatisfactory. This chapter explores several innovative biomaterials-based solutions, such as plugs, adhesives, fillers, and stem cell-based therapies. The key approaches and treatment outcomes of these advanced therapies are examined, focusing on their ability to modulate the immune response, promote tissue healing, and improve patient outcomes. Additionally, the chapter discusses future directions, including the optimization of biomaterial designs, enhancement of delivery and retention of regenerative therapies, and a deeper understanding of the underlying mechanisms of healing.

Published
2024
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44. Criteria for preclinical models of cholangiocarcinoma:scientific and medical relevance

Author

Calvisi, Diego, Boulter, Luke, Vaquero, Javier, Saborowski, Anna, Fabris, Luca, Rodrigues, Pedro, Coulouarn, Cédric, Castro, Rui, Segatto, Oreste, Raggi, Chiara, van der Laan, Luc, Carpino, Guido, Goeppert, Benjamin, Roessler, Stephanie, Kendall, Timothy, Evert, Matthias, Gonzalez-Sanchez, Ester, Valle, Juan, Vogel, Arndt, Bridgewater, John, Borad, Mitesh, Gores, Gregory, Roberts, Lewis, Marin, Jose, Andersen, Jesper, Alvaro, Domenico, Forner, Alejandro, Banales, Jesus, Cardinale, Vincenzo, Macias, Rocio, Vicent, Silve, Chen, Xin, Braconi, Chiara, Verstegen, Monique, Fouassier, Laura, Scheiter, Alexander, Selaru, Florin, Evert, Katja, Utpatel, Kirsten, Broutier, Laura, Cadamuro, Massimiliano, Huch, Meritxell, Goldin, Robert, Gradilone, Sergio, Saito, Yoshimasa, University of Regensburg, University of Edinburgh, Instituto de Salud Carlos III [Madrid] (ISC), Hannover Medical School [Hannover] (MHH), Yale School of Medicine [New Haven, Connecticut] (YSM), University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU), Oncogenesis, Stress, Signaling (OSS), Université de Rennes (UR)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM), CRLCC Eugène Marquis (CRLCC), Universidade de Lisboa, Università degli Studi di Firenze = University of Florence (UniFI), Erasmus University Medical Center [Rotterdam] (Erasmus MC), Università degli Studi di Roma 'Foro Italico', Heidelberg University Hospital [Heidelberg], University of Barcelona, Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas y Digestivas (CIBERehd), Liver Unit, Clínica Universitaria, CIBER-EHD, Institut d'Investigació Biomèdica de Bellvitge [Barcelone] (IDIBELL), The Christie NHS Foundation Trust [Manchester, Royaume-Uni], University of Manchester [Manchester], University College of London [London] (UCL), Mayo Clinic, Mayo Clinic [Rochester], Universidad de Salamanca, University of Copenhagen = Københavns Universitet (UCPH), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA), Universidad Pública de Navarra [Espagne] = Public University of Navarra (UPNA), University of California [San Francisco] (UC San Francisco), University of California (UC), University of Glasgow, Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), The authors thank the European Network for the Study of Cholangiocarcinoma (ENS-CCA) and the European H2020 COST Action CA18122. The authors also acknowledge the valuable contributions of the external advisory panel. C.C. is supported by Inserm, Université de Rennes 1 and by a grant from the French Ministry of Health and the French National Cancer Institute (PRT-K20-136), CHU Rennes, CLCC Eugène Marquis, Rennes. M.M.A.V. and L.J.W.v.d.L. are supported by Medical Delta Regenerative Medicine 4D (Generating complex tissues with stem cells and printing technology) and TKI-LSH grant EMC-LSH19002. S.R. is supported by the German Research Foundation (DFG, project no. 314905040 and no. 493697503) and by German Cancer Aid (Deutsche Krebshilfe, project no. 70113922). S.V. is supported by Ministerio de Ciencia, Innovación y Universidades, Convocatoria 2019 para incentivar la Incorporación Estable de Doctores (IED2019-001007-I), by FEDER/Ministerio de Ciencia, Innovación y Universidades – Agencia Estatal de Investigación (PID2020‐116344‐RB‐100) and by the Government of Navarra-Health Research Department (58, and 2018). J.V. is funded by Ministerio de Ciencia e Innovación, part of Agencia Estatal de Investigación (AEI), through the Retos Investigación grant number PID2019-108651RJ-I00/DOI 10.13039/501100011033. The authors thank CERCA Programme/Generalitat de Catalunya for institutional support. R.I.R.M. and J.J.G.M. are supported by Instituto de Salud Carlos III, Spain (PI20/00189, PI19/00819) co-funded by the European Union. L. Fouassier belongs to a team supported by the Fondation pour la Recherche Médicale (Equipe FRM 2020 no. EQU202003010517) and is supported by Inserm and Sorbonne Université, INCa and ITMO Cancer of Aviesan within the framework of the 2021–2030 Cancer Control Strategy, on funds administered by Inserm.

Subjects
Hepatology, [SDV]Life Sciences [q-bio], Gastroenterology, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
Abstract

International audience; Cholangiocarcinoma (CCA) is a rare malignancy that develops at any point along the biliary tree. CCA has a poor prognosis, its clinical management remains challenging, and effective treatments are lacking. Therefore, preclinical research is of pivotal importance and necessary to acquire a deeper understanding of CCA and improve therapeutic outcomes. Preclinical research involves developing and managing complementary experimental models, from in vitro assays using primary cells or cell lines cultured in 2D or 3D to in vivo models with engrafted material, chemically induced CCA or genetically engineered models. All are valuable tools with well-defined advantages and limitations. The choice of a preclinical model is guided by the question(s) to be addressed; ideally, results should be recapitulated in independent approaches. In this Consensus Statement, a task force of 45 experts in CCA molecular and cellular biology and clinicians, including pathologists, from ten countries provides recommendations on the minimal criteria for preclinical models to provide a uniform approach. These recommendations are based on two rounds of questionnaires completed by 35 (first round) and 45 (second round) experts to reach a consensus with 13 statements. An agreement was defined when at least 90% of the participants voting anonymously agreed with a statement. The ultimate goal was to transfer basic laboratory research to the clinics through increased disease understanding and to develop clinical biomarkers and innovative therapies for patients with CCA.

Published
2023

48. Biostimulatory Micro‐Fragmented Nanofiber‐Hydrogel Composite Improves Mesenchymal Stem Cell Delivery and Soft Tissue Remodeling

Author

Yao, Zhi‐Cheng, primary, Yang, Yueh‐Hsun, additional, Kong, Jiayuan, additional, Zhu, Yining, additional, Li, Ling, additional, Chang, Calvin, additional, Zhang, Chi, additional, Yin, Jason, additional, Chao, Jeffrey, additional, Selaru, Florin M., additional, Reddy, Sashank K., additional, and Mao, Hai‐Quan, additional

Published
2022
Full Text
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49. Antibody Response Six Months after SARS-CoV-2 mRNA Vaccination in Patients with Inflammatory Bowel Disease

Author

Frey, Sarah, primary, Chowdhury, Reezwana, additional, Connolly, Caoilfhionn M., additional, Werbel, William A., additional, Segev, Dorry L., additional, Parian, Alyssa M., additional, Tsipotis, Evangelos, additional, Dudley-Brown, Sharon, additional, Lazarev, Mark, additional, Melia, Joanna M., additional, Truta, Brindusa, additional, Yu, Huimin, additional, and Selaru, Florin M., additional

Published
2022
Full Text
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