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Drug contamination appears to be responsible for a series of deaths from kidney failure among Haitian children. Between Oct, 1995 and Oct, 1996, 109 children developed kidney failure. Detailed records were kept on 87 children who remained in Haiti for treatment and 98% of these children died. Over one-quarter of the children transported to the US for treatment died. A locally manufactured acetaminophen syrup was strongly linked to these cases, and analysis of 36 different bottles revealed contamination with diethylene glycol in concentrations as high as 20%., Context. -- Contaminated pharmaceutical products can result in substantial morbidity and mortality and should be included in the differential diagnosis of deaths of unknown origin. Objective. -- To investigate an outbreak of deaths among children from acute renal failure in Haiti to determine the etiology and institute control measures. Design. -- Case-control study, cohort study, and laboratory toxicologic evaluation. Setting. -- Pediatric population of Haiti. Participants. -- Cases were defined as Haitian residents younger than 18 years with idiopathic anuria or severe oliguria for 24 hours or longer. Febrile hospitalized children without renal failure were enrolled as control subjects. Main Outcome Measure. -- The odds of exposure to suspected etiologic agents among cases and controls. Results. -- We identified 109 cases of acute renal failure among children. The clinical syndrome included renal failure, hepatitis, pancreatitis, central nervous system impairment, coma, and death. Of 87 patients with follow-up information who remained in Haiti for treatment, 85 (98%) died; 3 (27%) of 11 patients transported to the United States for intensive care unit management died before hospital discharge. A locally manufactured acetaminophen syrup was highly associated with disease (odds ratio, 52.7; 95% confidence interval, 15.2-197.2). Diethylene glycol (DEG) was found in patients' bottles in a median concentration of 14.4%. The median estimated toxic dose of DEG was 1.34 mL/kg (range, 0.22-4.42 mL/kg). Glycerin, a raw material imported to Haiti and used in the acetaminophen formulation, was contaminated with 24% DEG. Conclusions. -- An epidemic of severe systemic toxicity and deaths from DEG-contaminated acetaminophen syrup occurred in Haiti. Good manufacturing practice regulations should be used by all pharmaceutical manufacturers to prevent such tragedies.

Elderly people with chronic diseases who live alone and have no social contacts appear to have the highest risk of dying during a prolonged heat wave. Following the heat wave in July, 1995, in Chicago, researchers interviewed relatives and friends of 339 who had died and 339 survivors, who served as the control group. Those who were bedridden, lived alone on an upper floor and did not engage in social activities had the highest risk of dying. An air conditioner reduced the risk of death substantially as did access to transportation. At least 700 people died during the heat wave who might not have died otherwise.