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In meinem Referat erl��utere ich die technischen Features der drei neuen Systeme zur Lentikel-Extraktion der Firmen Schwind (ATOS), Zeiss (VisuMax 800) und Ziemer (Z8). Im Gegensatz zu den Maschinen der 1. und 2. Generation (VisuMax und VisuMax 500, Carl Zeiss Meditec AG) verf��gen alle drei [zum vollst��ndigen Text gelangen Sie ��ber die oben angegebene URL]

Wir berichten ��ber eine Fallserie von 10 Patienten nach refraktivem Linsenaustausch mit einer nicht-diffraktiven EDOF-IOL (Vivity, Alcon). Pr��operativ waren alle Patienten hyperop und hatten einen cc-Visus von mindestens 1,0. Bei allen Patienten wurde eine Mini-Monovision zwischen 0,75���1,25 [zum vollst��ndigen Text gelangen Sie ��ber die oben angegebene URL]

Purpose: To investigate changes of corneal thickness spatial profile (CTSP), corneal volume (CV) distribution, and total corneal refractive power (TCRP) over a course of 60 months after uneventful Descemet membrane endothelial keratoplasty (DMEK). Methods: In our prospective, comparative study, sixty DMEK cases without intraoperative and postoperative complications and with complete 60-month follow-up were included (group 1). CTSP at corneal apex (CCT) and at 2 mm, 4 mm, 6 mm, and 8 mm rings, CV in 3 mm, 5 mm, 7 mm, and 10 mm zones, and TCRF in 2 mm, 4 mm 6 mm, and 8 mm zones were evaluated preoperatively and at 3, 6, 12, 24, and 60 months postoperatively. The 60-month results were compared to an age-matched group of uncomplicated pseudophakic eyes (group 2; n = 20). Results: The CCT and CTSP at 2, 4, and 6 mm increased significantly at 60 months compared to 3-month outcomes (P < 0.001). Similarly, CV increased significantly in 3 mm, 5 mm, and 7 mm zones at 60 months compared to 3 months outcomes (P < 0.001). The TCRP showed in all zones a significant decrease at 3 months (P < 0.001) followed by a continuous and significant increase at 60 months (P < 0.001). The 60-month CCT and CTSP at 2 mm were similar to group 2 (P ≥ 0.094). Conclusion: Sixty months after uneventful DMEK, CT within the central 2 mm zone and CV at 3 mm zone were similar to uncomplicated pseudophakic eyes. A continuous and statistically significant increase of TCRP was observed in all measured zones after the 3-month examination. [InlineMediaObject not available: see fulltext.]. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Hintergrund: Die Small Incision Lenticule Extraction wurde von Sekundo und Blum entwickelt und wurde bisher an 5 Millionen Augen durchgef��hrt. Das zugelassene Spectrum erstreckt sich auf Myopie mit/ohne myopen Astigmatismus. Methode: Die einj��hrige Zulassungsstudie zur Hyperopie-Behandlung [zum vollst��ndigen Text gelangen Sie ��ber die oben angegebene URL]

Purpose: To examine vision-related quality of life in patients with diabetic macular edema (DME) treated with intravitreal aflibercept (EYLEA, Regeneron Pharmaceuticals, Inc, Tarrytown, NY). Design: AQUA was a multicenter, open-label, single-arm, phase 4 study. Participants: Adults 18 years of age or older with type 1 or 2 diabetes mellitus and DME. Methods: Patients received intravitreal aflibercept 2 mg every 8 weeks for 52 weeks, after 5 initial doses every 4 weeks. Main Outcome Measures: The primary outcome was the change in 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25) total score from baseline to week 52. Secondary outcomes included the change in NEI VFQ-25 near and distant activities subscale scores, best-corrected visual acuity (BCVA; Early Treatment Diabetic Retinopathy Study [ETDRS] letters), and central retinal thickness (CRT) from baseline to week 52. Change in NEI VFQ-25 score at week 52 for better-seeing eyes (BSEs) and worse-seeing eyes (WSEs) also was evaluated. Results: A total of 553 patients comprised the full analysis set, and 560 patients comprised the safety analysis set. At baseline, the mean NEI VFQ-25 total score was 70.12, mean BCVA was 61.5 ETDRS letters, and mean CRT was 464.81 μm. A mean of 8.8 injections were administered over 52 weeks. At week 52, the mean improvement from baseline in the NEI VFQ-25 total score was +6.11 (standard deviation [SD], 11.46); the corresponding improvements in near and distant activities were +11.37 (SD, 18.01) and +7.33 (SD, 17.32), respectively. Similarly, improvements in patients whose BSE and WSE were treated were 7.74 (SD, 13.59) and 5.48 (SD, 9.70), respectively. At week 52, mean change in BCVA was +10.0 ETDRS letters (SD, 8.0 ETDRS letters), and mean change in CRT was –175.38 μm (SD, 132.62 μm). Overall, 53.6% of patients reported treatment-emergent adverse events (TEAEs), of whom 26.8% experienced an ocular TEAE in the study eye. The most common serious ocular TEAE was endophthalmitis (0.5% [n = 3]). Five deaths (0.9%) were reported, but were not considered treatment related. Conclusions: Intravitreal aflibercept was associated with clinically meaningful improvements in NEI VFQ-25 total score over 52 weeks in patients with DME; these were even more pronounced for near than for distant activities. Adverse events were consistent with the known safety profile of intravitreal aflibercept.

Purpose: Although currently rare due to more accurate preoperative evaluations and modern surgical techniques, iatrogenic ectasia remains a complication after refractive surgery. Small Incision Lenticule Extraction (SMILE) and photorefractive keratectomy (PRK) are superior in preserving corneal biomechanics[for full text, please go to the a.m. URL], 34. Kongress der Deutschsprachigen Gesellschaft für Intraokularlinsen-Implantation, interventionelle und refraktive Chirurgie

Purpose: To evaluate the 10-year results of Refractive Lenticule Extraction (ReLEx®) as Small Incision Lenticule Extraction technique (SMILE) for treatment of myopia and myopic astigmatism. Setting: Department of Ophthalmology, Helios Hospital Erfurt, Germany and Department of Ophthalmology,[zum vollständigen Text gelangen Sie über die oben angegebene URL], 92. Versammlung des Vereins Rhein-Mainischer Augenärzte

In diesem Referat stelle ich unsere Arbeiten der letzten 3 Jahre über die Biomechanik der menschlichen Hornhaut nach Myopie-Behandlung. Getestet wurden paarige Hornhäute verstorbener ex-vivo mittels 2D-Extensiometrie. Gegeneinander getestet wurden Femto-Lasik, PRK und SMILE. Darüber hinaus[zum vollständigen Text gelangen Sie über die oben angegebene URL], 92. Versammlung des Vereins Rhein-Mainischer Augenärzte