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AbstractPurposeConclusionsSince 2014, an educational activity on radiation and health in northern Japan has been carried out by young scientists, the so-called ‘Educational Symposium on Radiation and Health (ESRAH)’. Close cooperation has been continued in preparing for any possible emergency response to radiation accidents because several facilities, e.g., the Tomari Nuclear Power Plant in Hokkaido and the Low-Level Radioactive Waste Disposal Facility in Aomori prefecture. The ESRAH meeting has provided informational exchange and discussion forum on a broad range of subjects in various. In 2023, the 10th Memorial ESRAH meeting took place to boost scientific understanding and multidisciplinary collaborations for young scientists. Herein, we report on the ESRAH2023 symposium and analyze the research categories of young scientists from the past 10-year presentations.To date, the ESRAH meeting has successfully provided a chance for multi-disciplinary research, which accounted for 27% of the total despite the COVID-19 pandemic. We found that the fraction of multi-disciplinary research in 2023 was the highest during 10-year ESRAH meetings. Meanwhile, amongst the research categories, physics, chemistry, and pharmacological studies were indicated to be less for young scientists. It is desired that further collaboration between physics, chemistry, and pharmacology in addition to the current fields would not only clarify radiation effects on the human body but also promote emergency medical care for radiation exposure in the future. [ABSTRACT FROM AUTHOR]

Boron neutron capture therapy (BNCT) is a unique radiotherapy of selectively eradicating tumor cells using boron compounds (e.g., 4-borono-l-phenylalanine [BPA]) that are heterogeneously taken up at the cellular level. Such heterogenicity potentially reduces the curative efficiency. However, the effects of temporospatial heterogenicity on cell killing remain unclear. With the technical combination of radiation track detector and biophysical simulations, this study revealed the cell cycle-dependent heterogenicity of BPA uptake and subsequent biological effects of BNCT on HeLa cells expressing fluorescent ubiquitination-based cell cycle indicators, as well as the modification effects of polyvinyl alcohol (PVA). The results showed that the BPA concentration in the S/G2/M phase was higher than that in the G1/S phase and that PVA enhances the biological effects both by improving the uptake and by canceling the heterogenicity. These findings might contribute to a maximization of therapeutic efficacy when BNCT is combined with PVA and/or cell cycle-specific anticancer agents. [ABSTRACT FROM AUTHOR]