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21. Prophylactic treatment with alkaline phosphatase in cardiac surgery induces endogenous alkaline phosphatase release.

Author

Kats, S., Brands, Ruud, Hamad, M.A., Seinen, W., Scharnhorst, V., Wulkan, R.W., Schönberger, J.P., Oeveren, van, W., Kats, S., Brands, Ruud, Hamad, M.A., Seinen, W., Scharnhorst, V., Wulkan, R.W., Schönberger, J.P., and Oeveren, van, W.

Abstract

Introduction: Laboratory and clinical data have implicated endotoxin as an important factor in the inflammatory response to cardiopulmonary bypass. We assessed the effects of the administration of bovine intestinal alkaline phosphatase (bIAP), an endotoxin detoxifier, on alkaline phosphatase levels in patients undergoing coronary artery bypass grafting. Methods: A total of 63 patients undergoing coronary artery bypass grafting were enrolled and prospectively randomized. Bovine intestinal alkaline phosphatase (n=32) or placebo (n=31) was administered as an intravenous bolus followed by continuous infusion for 36 hours. The primary endpoint was to evaluate alkaline phosphatase levels in both groups and to find out if administration of bIAP to patients undergoing CABG would lead to endogenous alkaline phosphatase release. Results: No significant adverse effects were identified in either group. In all the 32 patients of the bIAP-treated group, we found an initial rise of plasma alkaline phosphatase levels due to bolus administration (464.27±176.17 IU/L). A significant increase of plasma alkaline phosphatase at 4-6 hours postoperatively was observed (354.97±95.00 IU/L) as well. Using LHA inhibition, it was shown that this second peak was caused by the generation of Tissue Non Specific Alkaline Phosphatase (TNSALP-type alkaline phosphatase). Conclusions: Intravenous bolus administration plus 8 hours continuous infusion of alkaline phosphatase in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass results in endogenous alkaline phosphatase release. This endogenous alkaline phosphatase may play a role in the immune defense system.

Published
2014

22. Safety and efficacy of Danisco Xylanase G/L (endo-1,4-beta-xylanase) as a feed additive for chickens for fattening, laying hens and ducks for fattening. Scientific Opinion of the Panel on Additives and Products or Substances used in Animal Feed and of the Panel on Genetically Modified Organisms:(Question No EFSA-Q-2006-137)

Author

Bories, G., Brantom, P., Brufau de Barberá, J., Chesson, A, Cocconcelli, P. S., Debski, B., Dierick, N., Franklin, A., Gropp, J., Halle, I., Hogstrand, C., de Knecht, J., Leng, L., Haldorsen, A.-K. L., Mantovani, A., Mézes, M., Nebbia, C., Rambeck, W., Rychen, G., von Wright, A., Wester, P., Andersson, H. C., Arpaia, S., Bartsch, D., Casacuberta, J., Davies, H., De Loose, M., Hendriksen, N. B., Herman, L., Kärenlampi, S., Kiss, J., Kryspin-Sørensen, I., Kuiper, H. A., Nes, I., Panopoulos, N., Perry, J., Pöting, A., Schiemann, J., Seinen, W., Sweet, J. B., and Wal, J. M.

Published
2007

24. Opinion of the Scientific Panel on Genetically Modified Organisms on an application (Reference EFSA-GMO-NL-2005-18) for the placing on the market of the glufosinate tolerant soybean A2704-12, for food and feed uses, import and processing under Regulation (EC) No 1829/2003 from Bayer CropScience:(Question No EFSA-Q-2005-174)

Author

Andersson, H. C., Arpaia, S., Bartsch, D., Casacuberta, J., Davies, H., Einspanier, R., Herman, L., De Loose, M., Hendriksen, N. B., Kärenlampi, S., Kiss, J., Kryspin-Sørensen, I., Kuiper, H., Nes, I., Panopoulos, N., Perry, J., Pöting, A., Schiemann, J., Seinen, W., Sweet, J., and Wal, J-M.

Published
2007

25. Opinion of the Scientific Panel on genetically Modified Organisms on an application (Reference EFSA-GMO-NL-2005-12) for the placing on the market of insect-resistant genetically modified maize 59122, for food and feed uses, import and processing under Regulation (EC) No 1829/2003, from Pioneer Hi-Bred International, Inc. and Mycogen Seeds, c/o Dow Agrosciences LLC:(Question No EFSA-Q-2005-045)

Author

Andersson, H. C., Arpaia, S., Bartsch, D., Casacuberta, J., Davies, H., Herman, L., De Loose, M., Hendriksen, N. B., Kärenlampi, S., Kiss, J., Kryspin-Sørensen, I., Kuiper, H., Nes, I., Panopoulos, N., Perry, J., Pöting, A., Schiemann, J., Seinen, W., Sweet, J., and Wal, J.-M.

Published
2007

26. Opinion of the Scientific Panel on Additives and Products or Substances used in Animal Feed and the Scientific Panel on genetically Modified Organisms on the safety and efficacy of the enzyme preparation Rovabio TM PHY AP/LC (3-phytase) as feed additive for chickens for fattening, laying hens, piglets and pigs for fattening in accordance with Regulation (EC) No 1831/2003:(Question No EFSA-Q-2005-281)

Author

Bories, G., Brantom, P., Brufau de Barberá, J., Chesson, A, Cocconcelli, P. S., Debski, B., Dierick, N., Franklin, A., Gropp, J., Halle, I., Hogstrand, C., de Knecht, J., Leng, L., Haldorsen, A.-K. L., Mantovani, A., Mézes, M., Nebbia, C., Rambeck, W., Rychen, G., von Wright, A., Wester, P., Andersson, H. C., Arpaia, S., Bartsch, D., Casacuberta, J., Davies, H., De Loose, M., Einspanier, R., Hendriksen, N. B., Herman, L., Kärenlampi, S., Kiss, J., Kryspin-Sørensen, I., Kuiper, H. A., Nes, I., Panopoulos, N., Perry, J., Pöting, A., Schiemann, J., Seinen, W., Sweet, J. B., and Wal, J.-M.

Published
2007

31. Opinion of the Scientific Panel on Genetically Modified Organisms on an application (Reference EFSA-GMO-NL-2005-13) for the placing on the market of glufosinate-tolerant genetically modified LLCotton25, for food and feed uses, and import and processing under Regulation (EC) No 1829/2003 from Bayer CropScience:(Question No EFSA-Q-2005-047)

Author

Andersson, H. C., Arpaia, S., Bartsch, D., Casacuberta, J., Davies, H., Einspanier, R., Herman, L., De Loose, M., Hendriksen, N. B., Kärenlampi, S., Kiss, J., Kryspin-Sørensen, I., Kuiper, H., Nes, I., Panopoulos, N., Perry, J., Pöting, A., Schiemann, J., Seinen, W., Sweet, J., and Wal, J.-M.

Published
2006

32. Opinion of the Scientific Panel on Genetically Modified Organisms on an application (Reference EFSA-GMO-UK-2004-08) for the placing on the market of products produced from glyphosate-tolerant genetically modified sugar beet H7-1, for food and feed uses, under Regulation (EC) No 1829/2003 from KWS SAAT AG and Monsanto. (Question No EFSA-Q-2004-164)

Author

Andersson, H. C., Arpaia, S., Bartsch, D., Casacuberta, J., Davies, H., Einspanier, R., De Loose, M., Hendriksen, N. B., Herman, L., Kärenlampi, S. O., Kiss, J., Kryspin-Sørensen, I., Kuiper, H., Nes, I., Panopoulos, N., Perry, J., Pöting, A., Schiemann, J., Seinen, W., Sweet, J., and Wal, J.-M.

Published
2006

33. Opinion of the Scientific Panel on Genetically Modified Organisms on a request from the Commission related to the notification (Reference C/SE/96/3501) for the placing on the market of genetically modfied potato EH92-527-1 with altered starch composition, for cultivation and production of starch, under Part C of Directive 2001/18/EC from BASF Plant Science:(Question No EFSA-Q-2005-023)

Author

Andersson, C., Bartsch, D., Buhk, H.-J., Davies, H., De Loose, M., Gasson, M., Hendriksen, N. B., Heritage, J., Kärenlampi, S., Kryspin-Sørensen, I., Kuiper, H., Nuti, M., O´Gara, F., Puigdomenech, P., Sakellaris, G., Schiemann, J., Seinen, W., Sessitsch, A., Sweet, J., van Elsas, J. D., and Wal, J.-M.

Published
2006

34. Opinion of the Scientific Panel on Genetically Modified Organisms on the Post Market Environmental Monitoring (PMEM) of genetically modified plants:(Question No EFSA-Q-2004-061)

Author

Andersson, H. C., Bartsch, D., Buhk, H.-J., Davies, H., DeLoose, M., Gasson, M., Hendriksen, N. B., Heritage, J., Kärenlampi, S., Kryspin-Sørensen, I., Kuiper, H., Nuti, M., O´Gara, F., Puigdomenech, P., Sakellaris, G., Schiemann, J., Seinen, W., Sessitsch, A., Sweet, J., van Elsas, J. D., and Wal, J.-M.

Published
2006

35. Guidance document of the Scientific Panel on Genetically Modified Organisms for renewal of authorisations of existing GMO products lawfully placed on the market, notified according to Articles 8 and 20 of regulation (EC) No 1829/2003. (Question No EFSA-Q-2003-005C)

Author

Andersson, H. C., Arpaia, S., Bartsch, D., Casacuberta, J., Davies, H., Einspanier, R., Herman, L., De Loose, M., Hendriksen, N. B., Kärenlampi, S., Kiss, J., Kryspin-Sørensen, I., Kuiper, H., Nes, I., Panopoulos, N., Perry, J., Pöting, A., Schienmann, J., Seinen, W., Sweet, J., and Wal, J.-M.

Published
2006

36. Guidance document of the Scientific Panel on genetically modified organisms for the risk assessment of genetically modified plants and derived food and feed. (Question no EFSA-Q-2003-005)

Author

Andersson, C., Bartsch, D., Buhk, H. J., Davies, H., De Loose, M., Gasson, M., Hendriksen, N. B., Hill, C., Kärenlampi, S., Kryspin-Sørensen, I., Kuiper, H., Nuti, M., O'Gara, F., Puigdomenech, P., Sakellaris, G., Schiemann, J., Seinen, W., Sessitsch, A., Sweet, J., van Elsas, J. D., and Wal, J.-M.

Published
2006

38. Guidance document of the Scientific Panel on Genetically Modified Organisms for renewal of authorisations of existing GMO products lawfully placed on the market, notified according to Articles 8 and 20 of Regulation (EC) No 1829/2003

Author

Andersson, H. C., Arpaia, S., Bartsch, D., Casacuberta, J., Davies, H., Einspanier, R., Herman, L., De Loose, M., Hendriksen, N. B., Kärenlampi, S., Kiss, J., Kryspin-Sørensen, I., Kuiper, H., Nes, I., Panopoulos, N., Perry, J., Pöting, A., Schiemann, J., Seinen, W., Sweet, J., and Wal, J. M.

Published
2006

41. Opinion of the Scientific Panel on Genetically Modified Organisms on a request from the Commission related to the safeguard clause invoked by Hungary according to Article 23 of Directive 2001/18/EC (Question No EFSA-Q-2005-055)

Author

Andersson, H. C., Bartsch, D., Buhk, H.-J., Davies, H., De Loose, M., Gasson, M., Hendriksen, N. B., Heritage, J., Kärenlampi, S., Kryspin-Sørensen, I., Kuiper, H., Nuti, M., O´Gara, F., Puigdomenech, P., Sakellaris, G., Schiemann, J., Seinen, W., Sessitsch, A., Sweet, J., van Elsas, J. D., and Wal, J.-M.

Published
2005

42. Opinion of the Scientific Panel on Genetically Modified Organisms on an application (Reference EFSA-GMO-BE-2004-07) for the placing on the market of insect-protected glyphosate-tolerant genetically modified maize MON863 X MON 810 X NK603, for food and feed uses, and import and processing under Regulation (EC) No 1829/2003 from Mosanto (Question No EFSA-Q-2004-159)

Author

Andersson, H. C., Bartsch, D., Buhk, H.-J., Davies, H., De Loose, M., Gasson, M., Hendriksen, N. B., Heritage, J., Kärenlampi, S., Kryspin-Sørensen, I., Kuiper, H., Nuti, M., O´Gara, F., Puigdomenech, P., Sakellaris, G., Schiemann, J., Seinen, W., Sessitsch, A., Sweet, J., van Elsas, J. D., and Wal, J-M.

Published
2005

43. Opinion of the Scientific Panel on Genetically Modified Organisms on an application (Reference EFSA-GMO-UK-2004-06) for the placing on the market of insect-protected glyphosate-tolerant genetically modified maize MON863 X NK603, for food and feed uses, and import and processing under Regulation (EC) No 1829/2003 from Monsanto (Question No EFSA-Q-2004-154)

Author

Andersson, H. C., Bartsch, D., Buhk, H.-J., Davies, H., De Loose, M., Gasson, M., Hendriksen, N. B., Heritage, J., Kärenlampi, S., Kryspin-Sørensen, I., Kuiper, H., Nuti, M., O´Gara, F., Puigdomenech, P., Sakellaris, G., Schiemann, J., Seinen, W., Sessitsch, A., Sweet, J., van Elsas, J. D., and Wal, J.-M.

Published
2005

44. Opinion of the Scientific Panel on Genetically Modified Organisms on a request from the Commission related to the notification (Reference C/ES/01/01) for the placing on the market of insect-tolerant genetically modified maize 1507 for import, feed and industrial processing and cultivation, under Part C of Directive 2001/18/EC from Pioneer Hi-Bred International/Mycogen Seeds (Question No EFSA-Q-2004-072)

Author

Anderson, H. C., Bartsch, D., Buhk, H.-J., Davies, H., De Loose, M., Gasson, M., Hendriksen, N. B., Heritage, J., Kärenlampi, S., Kryspin-Sørensen, I., Kuiper, H., Nuti, M., O´Gara, F., Puigdomenech, P., Sakellaris, G., Schiemann, J., Seinen, W., Sessitsch, A., Sweet, J., van Elsas, J. D., and Wal, J.-M.

Published
2005

45. Introduction of ethoxy-resorufin-o-deethylase activity by halogenated aromatic hydrocarbons and polycyclic aromatic hydrocarbons in primary hepatocytes of the green frog (Rana esculenta)

Author

Rouhani Rankouhi, T., Koomen, B., Sanderson, J.T., Bosveld, A.T.C., Seinen, W., and van den Berg, M.

Subjects
fish, cytochrome-p4501a induction, population declines, in-vitro, cell-line, liver, cultures, Centrum Ecosystemen, Centre for Ecosystem Studies, stomatognathic diseases, endocrine disruptors, polychlorinated-biphenyls pcbs, xenopus-laevis, Wageningen Environmental Research
Abstract

In this study, we measured the ethoxy-resorufin-O-deethylase (EROD) activity in primary hepatocytes of the common green frog Rana esculenta as a biomarker for cytochrome P4501A induction. We exposed hepatocytes derived from male and female frogs to several halogenated aromatic hydrocarbons, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 2,3,4,7,8-pentachlorodibenzofuran (PCDF), polychlorinated biphenyls (PCB-126, PCB-118). and polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BaP), chrysene, anthracene, and pyrene. Exposure to PCB-118, anthracene, and pyrene, up to 1 μ M, did not induce EROD activity, whereas TCDD and PCDF induced EROD activity maximally. In our primary frog hepatocytes, exposure to chrysene and BaP resulted in median effective concentration values (EC50) in the high nM range (82-1035 nM). Exposure to TCDD, PCDF and PCB-126 resulted in EC50 values of 0.4 to 8, 0.07 to 0.7, and 3 to 133 nM, respectively, which is in the same range as EC50 values found in primary hepatocytes of birds. Compared to our frog hepatocytes, primary rat hepatocytes seem to be more sensitive to TCDD, chrysene. and BaP.

Published
2005

46. Opinion of the Scientific Panel on Genetically Modified Organisms on a request from the Commission related to the Notification (Reference C/DE/02/9) for the placing on the market of insect-protected genetically modified maize MON 863 X MON 810, for import and processing, under Part C of Directive 2001/18/EC from Monsanto (Question No EFSA-Q-2003-089)

Author

Andersson, H. C., Bartsch, D., Buhk, H.-J., Davies, H., De Loose, M., Gasson, M., Hendriksen, N. B., Heritage, J., Kärenlampi, S., Kryspin-Sørensen, I., Kuiper, H., Nuti, M., O´Gara, F., Puigdomenech, P., Sakellaris, G., Schiemann, J., Seinen, W., Sessitsch, A., Sweet, J., van Elsas, J. D., and Wal, J.-M.

Published
2005

48. Opinion of the Scientific Panel on Genetically Modified Organisms on an application (Reference EFSA-GMO-DE-2004-03) for the placing on the market of insect-protected genetically modified maize MON 863 X MON 810, for food and feed use, under Regulation (EC) No 1829/2003 from Monsanto (Question No EFSA-Q-2004-112)

Author

Andersson, H. C., Bartsch, D., Buhk, H.-J., Davies, H., De Loose, M., Gasson, M., Hendriksen, N. B., Heritage, J., Kärenlampi, S., Kryspin-Sørensen, I., Kuiper, H., Nuti, M., O´Gara, F., Puigdomenech, P., Sakellaris, G., Schiemann, J., Seinen, W., Sessitsch, A., Sweet, J., van Elsas, J. D., and Wal, J.-M.

Published
2005

49. Opinion of the Scientific Panel on Genetically Modified Organisms on a request from the Commission related to the notification (Reference C/F/96/05.10) for the placing on the market of insect resistant genetically modified maize Bt11, for cultivation, feed and industrial processing, under Part C of Directive 2001/18/EC from Syngenta Seeds (Question No EFSA-Q-2004-012)

Author

Andersson, H. C., Bartsch, D., Buhk, H.-J., Davies, H., De Loose, M., Gasson, M., Hendriksen, N. B., Heritage, J., Kärenlampi, S., Kryspin-Sørensen, I., Kuiper, H., Nuti, M., O`Gara, F., Puigdomenech, P., Sakellaris, G., Schiemann, J., Seinen, W., Sessitsch, A., Sweet, J., van Elsas, J. D., and Wal, J.-M.

Published
2005

50. Opinion of the Scientific Panel on Genetically Modified Organisms on an application (reference EFSA-GMO-NL-2004-02) for the placing on the market of insect-tolerant genetically modified maize 1507, for food use, under Regulation (EC) No 1829/2003 from Pioneer Hi-Bred International/Mycogen Seeds (Question no EFSA-Q-2004-087)

Author

Andersson, H. C., Bartsch, D., Buhk, H.-J., Davies, H., De Loose, M., Gasson, M., Hendriksen, N. B., Heritage, J., Kärenlampi, S., Kryspin-Sørensen, I., Kuiper, H., Nuti, M., O´Gara, F., Puigdomenech, P., Sakellaris, G., Schiemann, J., Seinen, W., Sessitsch, A., Sweet, J., van Elsas, J. D., and Wal, J.-M.

Published
2005

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