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17 results on '"Seilly, David J."'

1. Emergence of methicillin resistance predates the clinical use of antibiotics

Author

Larsen, Jesper, Raisen, Claire L., Ba, Xiaoliang, Sadgrove, Nicholas J., Padilla-González, Guillermo F., Simmonds, Monique S. J., Loncaric, Igor, Kerschner, Heidrun, Apfalter, Petra, Hartl, Rainer, Deplano, Ariane, Vandendriessche, Stien, Černá Bolfíková, Barbora, Hulva, Pavel, Arendrup, Maiken C., Hare, Rasmus K., Barnadas, Céline, Stegger, Marc, Sieber, Raphael N., Skov, Robert L., Petersen, Andreas, Angen, Øystein, Rasmussen, Sophie L., Espinosa-Gongora, Carmen, Aarestrup, Frank M., Lindholm, Laura J., Nykäsenoja, Suvi M., Laurent, Frederic, Becker, Karsten, Walther, Birgit, Kehrenberg, Corinna, Cuny, Christiane, Layer, Franziska, Werner, Guido, Witte, Wolfgang, Stamm, Ivonne, Moroni, Paolo, Jørgensen, Hannah J., de Lencastre, Hermínia, Cercenado, Emilia, García-Garrote, Fernando, Börjesson, Stefan, Hæggman, Sara, Perreten, Vincent, Teale, Christopher J., Waller, Andrew S., Pichon, Bruno, Curran, Martin D., Ellington, Matthew J., Welch, John J., Peacock, Sharon J., Seilly, David J., Morgan, Fiona J. E., Parkhill, Julian, Hadjirin, Nazreen F., Lindsay, Jodi A., Holden, Matthew T. G., Edwards, Giles F., Foster, Geoffrey, Paterson, Gavin K., Didelot, Xavier, Holmes, Mark A., Harrison, Ewan M., and Larsen, Anders R.

Published
2022
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6. A Secreted RNA Binding Protein Forms RNA-Stabilizing Granules in the Honeybee Royal Jelly

Author

Maori, Eyal, primary, Navarro, Isabela Cunha, additional, Boncristiani, Humberto, additional, Seilly, David J., additional, Rudolph, Konrad Ludwig Moritz, additional, Sapetschnig, Alexandra, additional, Lin, Chi-Chuan, additional, Ladbury, John Edward, additional, Evans, Jay Daniel, additional, Heeney, Jonathan Luke, additional, and Miska, Eric Alexander, additional

Published
2019
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8. Use of Proteins Identified through a Functional Genomic Screen To Develop a Protein Subunit Vaccine That Provides Significant Protection against Virulent Streptococcus suis in Pigs

Author

Brockmeier, Susan L., primary, Loving, Crystal L., additional, Nicholson, Tracy L., additional, Wang, Jinhong, additional, Peters, Sarah E., additional, Weinert, Lucy, additional, Chaudhuri, Roy, additional, Seilly, David J., additional, Langford, Paul R., additional, Rycroft, Andrew, additional, Wren, Brendan W., additional, Maskell, Duncan J., additional, and Tucker, Alexander W., additional

Published
2018
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11. A Fusion Intermediate gp41 Immunogen Elicits Neutralizing Antibodies to HIV-1

Author

Lai, Rachel P.J., primary, Hock, Miriam, additional, Radzimanowski, Jens, additional, Tonks, Paul, additional, Hulsik, David Lutje, additional, Effantin, Gregory, additional, Seilly, David J., additional, Dreja, Hanna, additional, Kliche, Alexander, additional, Wagner, Ralf, additional, Barnett, Susan W., additional, Tumba, Nancy, additional, Morris, Lynn, additional, LaBranche, Celia C., additional, Montefiori, David C., additional, Seaman, Michael S., additional, Heeney, Jonathan L., additional, and Weissenhorn, Winfried, additional

Published
2014
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12. Mixed Adjuvant Formulations Reveal a New Combination That Elicit Antibody Response Comparable to Freund's Adjuvants

Author

Lai, Rachel P. J., primary, Seaman, Michael S., additional, Tonks, Paul, additional, Wegmann, Frank, additional, Seilly, David J., additional, Frost, Simon D. W., additional, LaBranche, Celia C., additional, Montefiori, David C., additional, Dey, Antu K., additional, Srivastava, Indresh K., additional, Sattentau, Quentin, additional, Barnett, Susan W., additional, and Heeney, Jonathan L., additional

Published
2012
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17. Use of Proteins Identified through a Functional Genomic Screen To Develop a Protein Subunit Vaccine That Provides Significant Protection against Virulent Streptococcus suisin Pigs

Author

Brockmeier, Susan L., Loving, Crystal L., Nicholson, Tracy L., Wang, Jinhong, Peters, Sarah E., Weinert, Lucy, Chaudhuri, Roy, Seilly, David J., Langford, Paul R., Rycroft, Andrew, Wren, Brendan W., Maskell, Duncan J., and Tucker, Alexander W.

Abstract

ABSTRACTStreptococcus suisis a bacterium that is commonly carried in the respiratory tract and that is also one of the most important invasive pathogens of swine, commonly causing meningitis, arthritis, and septicemia. Due to the existence of many serotypes and a wide range of immune evasion capabilities, efficacious vaccines are not readily available. The selection of S. suisprotein candidates for inclusion in a vaccine was accomplished by identifying fitness genes through a functional genomics screen and selecting conserved predicted surface-associated proteins. Five candidate proteins were selected for evaluation in a vaccine trial and administered both intranasally and intramuscularly with one of two different adjuvant formulations. Clinical protection was evaluated by subsequent intranasal challenge with virulent S. suis. While subunit vaccination with the S. suisproteins induced IgG antibodies to each individual protein and a cellular immune response to the pool of proteins and provided substantial protection from challenge with virulent S. suis, the immune response elicited and the degree of protection were dependent on the parenteral adjuvant given. Subunit vaccination induced IgG reactive against different S. suisserotypes, indicating a potential for cross protection.

Published
2017
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