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3. Should COVID-19 vaccines be mandated in schools? - an international caregiver perspective.

Author

Baumer-Mouradian, Shannon, Hart, Rebecca, Bone, Jeffrey, Seiler, Michelle, Olson, Prasra, Keitel, Kristina, Manzano, Sergio, Gualco, Gianluca, Krupik, Danna, Schroter, Stephanie, Weigert, Rachel, Chung, SunHee, Thompson, Graham, Muhammad, Nina, Shah, Pareen, Gaucher, Nathalie, Lunoe, Maren, Evers, Megan, Pharisa Rochat, Cosette, Nelson, Courtney, Shefler Gal, Moran, Doucas, Adrianna, and Goldman, Ran

Subjects
Adult, COVID-19, COVID-19 Vaccines, Caregivers, Child, Cross-Sectional Studies, Humans, Schools, United States, Vaccination, Vaccines
Abstract

OBJECTIVES: Caregiver attitudes toward mandating COVID-19 vaccines for their children are poorly understood. We aimed to determine caregiver acceptability of COVID-19 vaccine mandates for schools/daycares and assess if opposition to mandates would result in removal of children from the educational system. STUDY DESIGN: Perform a cross-sectional, anonymous survey of adult caregivers with children ≤ 18 years presenting to 21 pediatric emergency departments in the United States, Canada, Israel, and Switzerland, November 1st through December 31st, 2021. The primary outcome was caregiver acceptance rates for school vaccine mandates, and the secondary outcomes included factors associated with mandate acceptance and caregiver intention to remove the child from school. RESULTS: Of 4,393 completed surveys, 37% of caregivers were opposed to any school vaccine mandate. Caregiver acceptance was lowest for daycare settings (33%) and increased as the childs level of education increased, college (55%). 26% of caregivers report a high likelihood (score of 8-10 on 0-10 scale) to remove their child from school if the vaccine became mandatory. Child safety was caregivers greatest concern over vaccine mandates. A multivariable model demonstrated intent to vaccinate their child for COVID-19 (OR = 8.9, 95% CI 7.3 to 10.8; P

Published
2022

6. COVID-19 Vaccine Acceptance Among Parents of Children With Multisystem Inflammatory Syndrome in Children

Author

Blanchard-Rohner, Geraldine, Sanchez, Carlos, Andre, Maya C., Bressieux-Degueldre, Sabrina, Grazioli, Serge, Perez, Marie-Helene, Wütz, Daniela, Schöbi, Nina, Welzel, Tatjana, Atkinson, Andrew, Schlapbach, Luregn J., Bielicki, Julia A., Trück, Johannes, Koehler, Henrik, Gysi, Spyridoula, Janz, Indra, Bieri, Andreas, Donner, Birgit, Hammer, Jürg, Heininger, Ulrich, von Kalckreuth, Clemens, Kohns, Malte, Mettauer, Nicole, Meyer, Alexandra, Reppucci, Diana, Schlaeppi, Chloé, Trachsel, Daniel, Vaezipour, Nina, Woerner, Andreas, Zutter, Andreas, Vanoni, Federica, Kottanattu, Lisa, Mazzara, Calogero, Severi Conti, Alessia, Aebi, Christoph, Agyeman, Philipp, Duppenthaler, Andrea, Glöckler, Martin, Pallivathukal, Sabine, Riedel, Thomas, Zimmermann, Petra, Cudré-Cung, Hong-Phuc, Pavlovic, Mladen, Bordessoule, Alice, Martin, Anne-Laure, Polito, Angelo, Wagner, Noemie, Rohr, Marie, L’Huillier, Arnaud, Amiet, Vivianne, Ferry, Thomas, Longchamp, David, Natterer, Julia, Oppenheim, Rebecca, Hofer, Michael, Buettcher, Michael, Wechselberger, Katharina, Donas, Alex, Germann, Sara, Lütolf Erni, Michaela, Kaiser, Daniela, Schwendener Scholl, Katharina, Peter Kuen, Hans, Hrup, Katja, Stritt, Janine, Bailey, Douggl G. N., Wachinger, Tanja, Beck, Ingrid, Birkenmaier, André, Rogdo, Bjarte, Lorenz, Philip, Iglowstein, Ivo, Zöhrer, Konstanze, Flade, Martin, Prader, Seraina, Pachlopnik Schmid, Jana, Seiler, Michelle, Meyer Sauteur, Patrick, Brotschi, Barbara, Weber, Kathrin, Whittaker, Elizabeth, and Faust, Saul N.

Published
2024
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7. Cardiac assessment and inflammatory markers in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV2 (PIMS-TS) treated with methylprednisolone versus intravenous immunoglobulins: 6-month follow-up outcomes of the randomised controlled Swissped RECOVERY trial

Author

Andre, Maya C., Sanchez, Carlos, Bressieux-Degueldre, Sabrina, Perez, Marie-Helene, Wütz, Daniela, Blanchard-Rohner, Geraldine, Grazioli, Serge, Schöbi, Nina, Trück, Johannes, Welzel, Tatjana, Atkinson, Andrew, Schlapbach, Luregn J., Bielicki, Julia, Koehler, Henrik, Gysi, Spyridoula, Janz, Indra, Bieri, Andreas, Donner, Birgit, Hammer, Jürg, Heininger, Ulrich, von Kalckreuth, Clemens, Kohns, Malte, Mettauer, Nicole, Meyer, Alexandra, Reppucci, Diana, Schlaeppi, Chloé, Trachsel, Daniel, Vaezipour, Nina, Woerner, Andreas, Zutter, Andreas, Vanoni, Federica, Kottanattu, Lisa, Mazzara, Calogero, Conti, Alessia Severi, Aebi, Christoph, Agyeman, Philipp, Duppenthaler, Andrea, Glöckler, Martin, Pallivathukal, Sabine, Riedel, Thomas, Zimmermann, Petra, Cudré-Cung, Hong-Phuc, Pavlovic, Mladen, Bordessoule, Alice, Martin, Anne-Laure, Polito, Angelo, Wagner, Noemie, Rohr, Marie, L'Huillier, Arnaud, Amiet, Vivianne, Ferry, Thomas, Longchamp, David, Natterer, Julia, Oppenheim, Rebecca, Hofer, Michael, Buettcher, Michael, Wechselberger, Katharina, Donas, Alex, Germann, Sara, Erni, Michaela Lütolf, Kaiser, Daniela, Scholl, Katharina Schwendener, Kuen, Hans Peter, Hrup, Katja, Stritt, Janine, Bailey, Douggl G.N., Wachinger, Tanja, Beck, Ingrid, Birkenmaier, André, Rogdo, Bjarte, Lorenz, Philip, Iglowstein, Ivo, Zöhrer, Konstanze, Flade, Martin, Prader, Seraina, Schmid, Jana Pachlopnik, Seiler, Michelle, Sauteur, Patrick Meyer, Brotschi, Barbara, Weber, Kathrin, Whittaker, Elizabeth, and Faust, Saul N.

Published
2024
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9. Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children: a propensity-weighted cohort study

Author

Chouli, Mohamed, Hamadouche, Nacera, Ladj, Mohamed Samir, Agrimbau Vázquez, Jorge, Carmona, Rodrigo, Collia, Adrian Gustavo, Ellis, Alejandro, Natta, Diego, Pérez, Laura, Rubiños, Mayra, Veliz, Natalia, Yori, Silvana, Britton, Philip N., Burgner, David P., Carey, Emma, Crawford, Nigel W., Giuliano, Hayley, McMinn, Alissa, Wong, Shirley, Wood, Nicholas, Holter, Wolfgang, Krainz, Matthias, Ulreich, Raphael, Zurl, Christoph, Dehoorne, Joke, Haerynck, Filomeen, Hoste, Levi, Schelstraete, Petra, Vandekerckhove, Kristof, Willems, Jef, Almeida Farias, Camila Giuliana, Almeida, Flávia Jacqueline, Alves Leal, Izabel, Araujo da Silva, André Ricardo, Araujo e Silva, Anna Esther, Barreiro, Sabrina T.A., Bomfim Prado da Silva, Daniella Gregória, Cervi, Maria Celia, dos Santos Naja Cardoso, Mirian Viviane, Henriques Teixeira, Cristiane, Jarovsky, Daniel, Martins Araujo, Julienne, Naaman Berezin, Eitan, Palazzi Sáfadi, Marco Aurélio, Paternina-de la Ossa, Rolando Andres, Souza Vieira, Cristina, Dimitrova, Anna, Ganeva, Margarita, Stefanov, Stefan, Telcharova-Mihaylovska, Albena, Biggs, Catherine M., Lopez, Alison, Scuccimarri, Rosie, Tan, Ryan, Wasserman, Sam, Withington, Davinia, Ampuero, Camila, Aravena, Javiera, Bustos B, Raul, Casanova, Daniel, Cruces, Pablo, Diaz, Franco, García-Salum, Tamara, Godoy, Loreto, Medina, Rafael A., Valenzuela Galaz, Gonzalo, Camacho-Moreno, Germán, Avila-Aguero, María L., Brenes-Chacón, Helena, Camacho-Badilla, Kattia, Ivankovich-Escoto, Gabriela, Naranjo-Zuniga, Gabriela, Soriano-Fallas, Alejandra, Ulloa-Gutierrez, Rolando, Yock-Corrales, Adriana, Amer, Maysa Abbas, Abdelmeguid, Yasmine, Ahmed, Yomna H.H.Z., Badib, Adham, Badreldin, Karim, Elkhashab, Yara, Heshmat, Hassan, Hussein, Amna, Mohamed Hussein, Amna Hussein, Ibrahim, Sandra, Shoman, Walaa, Yakout, Radwa M, Heinonen, Santtu, Angoulvant, François, Belot, Alexandre, Ouldali, Naïm, Beske, Florian, Heep, Axel, Masjosthusmann, Katja, Reiter, Karl, van den Heuvel, Ingeborg, von Both, Ulrich, Agrafiotou, Aikaterini, Antachopoulos, Charalampos, Charisi, Konstantina, Eleftheriou, Irini, Farmaki, Evangelia, Fotis, Lampros, Kafetzis, Dimitrios, Koletsi, Patra, Kourtesi, Katerina, Lampidi, Stavroula, Liakopoulou, Theodota, Maritsi, Despoina, Michailidou, Elisa, Milioudi, Maria, Mparmpounaki, Ioanna, Papadimitriou, Eleni, Papaevangelou, Vassiliki, Roilides, Emmanuel, Tsiatsiou, Olga, Tsolas, Georgios, Tsolia, Maria, Vantsi, Petrina, Banegas Pineda, Linda Yajeira, Borjas Aguilar, Karla Leversia, Cantillano Quintero, Edwin Mauricio, Ip, Patrick, Kwan, Mike Yat Wah, Kwok, Janette, Lau, Yu Lung, To, Kelvin, Wong, Joshua Sung Chih, David, Mate, Farkas, David, Kalcakosz, Szofia, Szekeres, Klaudia, Zsigmond, Borbala, Aslam, Nadeem, Luder, Anthony, Andreozzi, Laura, Bianco, Francesco, Bucciarelli, Valentina, Buonsenso, Danilo, Cimaz, Rolando, De Luca, Maia, Dellepiane, Rosa Maria, Fabi, Marianna, Filice, Emanuele, Lanari, Marcello, Lo Vecchio, Andrea, Mastrolia, Maria Vincenza, Mauro, Angela, Mazza, Angelo, Papa, Mario Virgilio, Romani, Lorenza, Scarano, Sara Maria, Simonini, Gabriele, Tipo, Vincenzo, Verdoni, Lucio, Macharia, Anne-Marie, Musiime, Grace, Reel, Bhupi, Wangai, Frederick, Pace, David, Torpiano, Paul, Anaya-Enriquez, Nancy, Carreon-Guerrero, Juan Manuel, Chacon-Cruz, Enrique, Cheung López, Mariana, Faugier Fuentes, Enrique, Fonseca Flores, Marisol, García-Domínguez, Miguel, Giron Vargas, Ana Luisa, Lopez-Delgado, Ivan, Lopez Hernández, Liliana, Menchaca Aguayo, Hector F., Montaño-Duron, Jesus Gilberto, Pérez-Gaxiola, Giordano, Ramos Tiñini, Pamela, Tostado-Morales, Edgardo, Valadez, Julio, Inchley, Christopher, Klevberg, Sjur, Knudsen, Per Kristian, Måseide, Per Helge, Carrera, Jose Manuel, Castaño, Elizabeth, Daza Timana, Carlos Alberto, De Leon, Tirza, Estripeaut, Dora, Levy, Jacqueline, Norero, Ximena, Record, Javier, Rojas-Bonilla, Magda, Wong, Mayra, Iramain, Ricardo, Hernandez, Roger, Huamán, Gian, Munaico, Manuel, Peralta, Carlos, Seminario, Diego, Zapata Yarlequé, Elmer Hans, Gadzinska, Justyna, Ludwikowska, Kamila, Mandziuk, Joanna, Okarska-Napierała, Magdalena, Alacheva, Zalina A., Alexeeva, Ekaterina, Ananin, Petr V., Antsupova, Margarita, Bakradze, Maya D., Berbenyuk, Anna, Bobkova, Polina, Borzakova, Svetlana, Chashchina, Irina L., El-Taravi, Yasmin, Fisenko, Andrey P., Gautier, Marina S., Glazyrina, Anastasia, Gorlenko, Cyrill, Grosheva, Mariia, Kiselev, Herman, Kondrikova, Elena, Korobyants, Evgeniya, Korsunskiy, Anatoliy A., Kovygina, Karina, Krasnaya, Ekaterina, Kurbanova, Seda, Kurdup, Maria K., Mamutova, Anna V., Mazankova, Lyudmila, Mitushin, Ilya L., Munblit, Daniel, Nargizyan, Anzhelika, Orlova, Yanina O., Osmanov, Ismail M., Polyakova, Anastasia S., Pushkareva, Anna, Romanova, Olga, Samitova, Elmira, Shvedova, Anastasia, Sologub, Anna, Iakovleva, Ekaterina, Tepaev, Rustem F., Tkacheva, Anna A., Yegiyan, Margarita, Yusupova, Valeriya, Zholobova, Elena, Grasa, Carlos Daniel, Epalza, Cristina, Lopez Segura, Nuria, Martinon-Torres, Federico, Melendo, Susana, Mendez-Echevarria, Ana, Mesa Guzmán, Juan Miguel, Palacios Argueta, Jorge Roberto, Rivero-Calle, Irene, Rivière, Jacques, Rodríguez-González, Moisés, Rojo, Pablo, Sanchez Manubens, Judith, Soler-Palacin, Pere, Soriano-Arandes, Antoni, Tagarro, Alfredo, Villaverde, Serena, Altman, Maria, Brodin, Petter, Horne, AnnaCarin, Palmblad, Karin, Brotschi, Barbara, Meyer Sauteur, Patrick, Pachlopnik Schmid, Jana, Prader, Seraina, Relly, Christa, Schlapbach, Luregn J., Seiler, Michelle, Strasser, Sophie, Trück, Johannes, Weber, Kathrin, Wütz, Daniela, Hamdan, Alaa, Melhem, Ibrahim, Moussa, Ahmed, Dunk, Joke, Ketharanathan, Naomi, Vermont, Clementien, Akyüz Özkan, Esra, Cetin, Benhur Sirvan, Erdeniz, Emine Hafize, Şahin, Irfan Oğuz, Borisova, Galina, Boyarchuk, Oksana, Boychenko, Lidiya, Boyko, Yaryna, Diudenko, Nadiia, Dyvonyak, Olha, Kasiyan, Olexandr, Katerynych, Kostiantyn, Kostyuchenko, Larysa, Mamenko, Marina, Melnyk, Kateryna, Miagka, Nelia, Nazarenko, Liliya, Nezgoda, Iryna, Rykova, Stanislava, Svyst, Olga, Teslenko, Maria, Trykosh, Mykola, Vasilenko, Nataliya, Volokha, Alla, Adams, Charlotte, Akomolafe, Toju, Al-Abadi, Eslam, Alders, Nele, Alifieraki, Styliani, Ansumanu, Hareef, Aston, Emily, Avram, Paula, Bamford, Alasdair, Banks, Millie, Basu Roy, Robin, Beattie, Thomas, Boleti, Olga, Bracken, Abbey, Broad, Jonathan, Cai, James, Carrol, Enitan D., Carter, Michael, Chandran, Anchit, Charlesworth, James, Chawla, Jaya, Cooper, Hannah, Cooray, Samantha, Davies, Patrick, Davis, Francesca, Drysdale, Simon B., Dzora, Ella, Emonts, Marieke, Evans, Ceri, Fidler, Katy, Foster, Caroline, Gong, Chen, Gongrun, Berin, Gonzalez, Carmen, Gorgun, Berin, Grandjean, Louis, Grant, Karlie, Guo, Jonathan, Hacohen, Yael, Hall, Jack, Hamid, Hytham K.S., Hassell, Jane, Hesketh, Christine, Hewlett, Jessica, Hnieno, Ahmad, Holt-Davis, Hannah, Hossain, Aleena, Hu, Shiying, Hudson, Lee D., Jheeta, Sharon, Johnson, Mae, Johnson, Sarah, Jyothish, Deepthi, Kampmann, Beate, Kavirayani, Akhila, Kelly, Deborah, Kirubakaran, Arangan, Kucera, Filip, Langer, Daniel, Lawson, George, Lees, Emily A, Lenihan, Rebecca, Lillie, Jon, Longbottom, Katherine, Lyall, Hermione, Mackdermott, Niamh, Maltby, Sarah, Mclelland, Thomas, McMahon, Anne-Marie, Miller, Danielle, Miranda, Mariana, Mirza, Luwaiza, Morrison, Zoe, Moshal, Karyn, Muller, Jennifer, Musuka, Phoebe, Myttaraki, Evangelia, Nadel, Simon, Nair, Sreedevi, Nuttall, Luke, Oremakinde, Oyinkansola, Osaghae, Daniella, Osman, Fatima, Ostrzewska, Anna, Paccagnella, Davide, Panthula, Mrinalini, Papachatzi, Eleni, Papadopoulou, Charalampia, Patel, Fahim, Patel, Harsita, Payne, Helen, Penner, Justin, Polandi, Shervin, Prendergast, Andrew J., Ramnarayan, Padmanabhan, Ranasinghe, Lasith, Ravichandran, Muthukumaran, Rhys-Evans, Sophie, Riordan, Andrew, Rodrigues, Charlene M.C., Roe, Lauren, Romaine, Sam, Schobi, Nina, Seddon, James, Shingadia, Delane, Sikdar, Oishi, Srivastava, Anand, Struik, Siske, Sun, Thomas, Tan, Rachel Wei, Taylor, Alice, Taylor, Amanda, Taylor, Andrew, Tran, Steven, Tsagkaris, Stavros, Tudor-Williams, Gareth, van den Berg, Sarah, van der Velden, Fabian, Ventilacion, Lyn, Wellman, Paul A., Withers Green, Joseph, Yanney, Michael P., Yeung, Shunmay, Badheka, Aditya, Badran, Sarah, Bailey, Dwight M., Burch, Anna Kathryn, Burns, Jane C., Cichon, Catherine, Cirks, Blake, Dallman, Michael D., Delany, Dennis R., Fairchok, Mary, Friedman, Samantha, Geracht, Jennifer, Langs-Barlow, Allison, Mann, Kelly, Padhye, Amruta, Quade, Alexis, Ramirez, Kacy Alyne, Rockett, John, Sayed, Imran Ali, Santos, Roberto P., Shahin, Amr A., Tremoulet, Adriana, Umaru, Samuel, Widener, Rebecca, Mujuru, Hilda Angela, Kandawasvika, Gwendoline, Channon-Wells, Samuel, Vito, Ortensia, McArdle, Andrew J, Seaby, Eleanor G, Shah, Priyen, Pazukhina, Ekaterina, Wilson, Clare, Broderick, Claire, D'Souza, Giselle, Keren, Ilana, Nijman, Ruud G, Carter, Michael J, De, Tisham, Hoggart, Clive, Whittaker, Elizabeth, Herberg, Jethro A, Kaforou, Myrsini, Cunnington, Aubrey J, Blyuss, Oleg, and Levin, Michael

Published
2023
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10. Willingness to Vaccinate Children against Influenza after the Coronavirus Disease 2019 Pandemic

Author

Ahmed, Sarah, Ali, Samina, Brown, Julie C., Craig, Simon, Davis, Adrienne L., Gaucher, Nathalie, Gianluca, Gualco, Goldman, Ran, Griffiths, Mark, Hall, Jeanine E., Hansen, Matt, Hurt, Thomas L., Kelly, Christopher, Klein, Eileen J., Kozer, Eran, Marneni, Shashidhar, Mater, Ahmed, Mistry, Rakesh, Parra, Cristina, Poonai, Naveen, Rao, Arjun, Sheridan, David, Shimizu, Naoki, Yue, Esther L., Goldman, Ran D., McGregor, Sophie, Marneni, Shashidhar R., Katsuta, Tomohiro, Griffiths, Mark A., Seiler, Michelle, Cotanda, Cristina Parra, Gelernter, Renana, Hoeffe, Julia, Gualco, Gianluca, Manzano, Sergio, Thompson, Graham C., and Ahmed, Sara

Published
2021
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12. COVID-19 Vaccine Acceptance Among Parents of Children With Multisystem Inflammatory Syndrome in Children

Author

Blanchard-Rohner, Geraldine; https://orcid.org/0000-0002-9974-2172, Sanchez, Carlos, Andre, Maya C, Bressieux-Degueldre, Sabrina, Grazioli, Serge, Perez, Marie-Helene, Wütz, Daniela; https://orcid.org/0000-0002-5186-2634, Schöbi, Nina, Welzel, Tatjana, Atkinson, Andrew, Schlapbach, Luregn J; https://orcid.org/0000-0003-2281-2598, Bielicki, Julia A, Trück, Johannes; https://orcid.org/0000-0002-0418-7381, Swissped RECOVERY Trial Group, et al, Prader, Seraina; https://orcid.org/0000-0002-2950-5411, Pachlopnik Schmid, Jana; https://orcid.org/0000-0002-6653-9047, Seiler, Michelle; https://orcid.org/0000-0002-1263-5818, Meyer Sauteur, Patrick, Brotschi, Barbara; https://orcid.org/0000-0002-4472-5199, Weber, Kathrin, Blanchard-Rohner, Geraldine; https://orcid.org/0000-0002-9974-2172, Sanchez, Carlos, Andre, Maya C, Bressieux-Degueldre, Sabrina, Grazioli, Serge, Perez, Marie-Helene, Wütz, Daniela; https://orcid.org/0000-0002-5186-2634, Schöbi, Nina, Welzel, Tatjana, Atkinson, Andrew, Schlapbach, Luregn J; https://orcid.org/0000-0003-2281-2598, Bielicki, Julia A, Trück, Johannes; https://orcid.org/0000-0002-0418-7381, Swissped RECOVERY Trial Group, et al, Prader, Seraina; https://orcid.org/0000-0002-2950-5411, Pachlopnik Schmid, Jana; https://orcid.org/0000-0002-6653-9047, Seiler, Michelle; https://orcid.org/0000-0002-1263-5818, Meyer Sauteur, Patrick, Brotschi, Barbara; https://orcid.org/0000-0002-4472-5199, and Weber, Kathrin

Abstract

Data on COVID-19 vaccine acceptability among parents of children with multisystem inflammatory syndrome (MIS-C) are limited. In this cohort of children with MIS-C, enrolled in the Swissped RECOVERY trial (NCT04826588), comparing intravenous immunoglobulins or methylprednisolone, who, in accordance with Swiss guidelines, were recommended for SARS-CoV-2 vaccination, 65% (73/112) of parents reported being vaccinated against SARS-CoV-2 before the MIS-C, while 70% were vaccinated after the MIS-C episode of their child. None of the children were vaccinated before the occurrence of the MIS-C, and only 9% (5/56) received the COVID-19 vaccine after the MIS-C. The predominant barriers to COVID-19 vaccination were concerns over potential side effects and insufficient support from their doctors. This emphasizes the crucial role of health care providers in promoting COVID-19 vaccination among children.

Published
2024

13. Caregivers' Willingness to Accept Expedited Vaccine Research During the COVID-19 Pandemic: A Cross-sectional Survey

Author

Goldman, Ran D., Marneni, Shashidhar R., Seiler, Michelle, Brown, Julie C., Klein, Eileen J., Cotanda, Cristina Parra, Gelernter, Renana, Yan, Tyler D., Hoeffe, Julia, Davis, Adrienne L., Griffiths, Mark A., Hall, Jeanine E., Gualco, Gianluca, Mater, Ahmed, Manzano, Sergio, Thompson, Graham C., Ahmed, Sara, Ali, Samina, and Shimizu, Naoki

Published
2020
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14. Diagnostic potential of IL6 and other blood-based inflammatory biomarkers in mild traumatic brain injury among children.

Author

Chiollaz, Anne-Cécile, Pouillard, Virginie, Habre, Céline, Seiler, Michelle, Romano, Fabrizio, Spigariol, Fabian, Schenk, Céline Ritter, Korff, Christian, Maréchal, Fabienne, Wyss, Verena, Gruaz, Lyssia, Montaner, Joan, Manzano, Sergio, and Sanchez, Jean-Charles

Subjects
BRAIN injuries, INTERLEUKIN-6, CHILD patients, BIOINDICATORS, BIOMARKERS
Abstract

Objectives: Inflammatory biomarkers, as indicators of biological states, provide a valuable approach for accurate and reproducible measurements, crucial for the effective management of mild traumatic brain injury (mTBI) in pediatric patients. This study aims to assess the diagnostic utility of blood-based inflammatory markers IL6, IL8, and IL10 in children with mTBI, including those who did not undergo computed tomography (CT) scans. Methods: A prospective multicentric cohort study involving 285 pediatric mTBI patients was conducted, stratified into CT-scanned and non-CT-scanned groups within 24 h post-trauma, alongside 74 control subjects. Biomarker levels were quantitatively analyzed using ELISA. Sensitivity and specificity metrics were calculated to determine the diagnostic efficacy of each biomarker. Results: A total of 223 mTBI patients (78%) did not undergo CT scan examination but were kept in observation for symptoms monitoring at the emergency department (ED) for more than 6 h (in-hospital-observation patients). Among CT-scanned patients (n = 62), 14 (23%) were positive (CT+). Elevated levels of IL6 and IL10 were found in mTBI children compared to controls. Within mTBI patients, IL6 was significantly increased in CT+ patients compared to both CT– and in-hospital-observation patients. No significant differences were observed for IL8 among the compared groups. IL6 yielded a specificity of 48% in identifying CT– and in-hospital-observation patients, with 100% sensitivity in excluding all CT+ cases. These performances were maintained whether IL6 was measured within 6 h or within 24 h after the trauma. Conclusion: The inflammatory marker IL6 emerges as a robust biomarker, showing promising stratification value for pediatric mTBI patients undergoing CT scans or staying in observation in a pediatric ED. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Antibiotic prescription for febrile children in European emergency departments: a cross-sectional, observational study

Author

Moll, Henriette A., Oostenbrink, Rianne, van Veen, Mirjam, Noordzij, Jeroen G., Smit, Frank, van Wermeskerken, Anne-Marie, Angoulvant, Francois, Dubos, Francois, Gras-Leguen, Christele, Desmarest, Marie, Aurel, Marie, Gajdos, Vincent, Joffre, Christelle, Mintegi, Santiago, Acedo, Yordana, Herrero Garcia, Laura, Medina, Inmaculada, Cózar, Juan Alonso, Fernandez Arribas, Jose Luis, Pinto, Sara, Sá, Gabriela, Mação, Patrícia, Silva, Daniela, Zarcos, Maria, Seiler, Michelle, Gervaix, Alain, Maconochie, Ian, Olesen, Hanne, Bønnelykke, Christiane, Parri, Niccolò, Fichera, Vito, Arrhigini, Alberto, Bressan, Silvia, Da Dalt, Liviana, Moldovan, Diana, Dreghiciu, Daniela-Maria, Bognar, Zsolt, Yilmaz, Hayri L., Sari Gökay, Sinem, van de Maat, Josephine, van de Voort, Elles, Nieboer, Daan, and Moll, Henriette

Published
2019
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21. The role of recessive inheritance in early-onset epileptic encephalopathies: a combined whole-exome sequencing and copy number study

Author

Papuc, Sorina M., Abela, Lucia, Steindl, Katharina, Begemann, Anaïs, Simmons, Thomas L., Schmitt, Bernhard, Zweier, Markus, Oneda, Beatrice, Socher, Eileen, Crowther, Lisa M., Wohlrab, Gabriele, Gogoll, Laura, Poms, Martin, Seiler, Michelle, Papik, Michael, Baldinger, Rosa, Baumer, Alessandra, Asadollahi, Reza, Kroell-Seger, Judith, Schmid, Regula, Iff, Tobias, Schmitt-Mechelke, Thomas, Otten, Karoline, Hackenberg, Annette, Addor, Marie-Claude, Klein, Andrea, Azzarello-Burri, Silvia, Sticht, Heinrich, Joset, Pascal, Plecko, Barbara, and Rauch, Anita

Published
2019
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22. Zungenverletzungen bei Kindern: Das Zürcher Zungenschema

Author

Seiler, Michelle, Schiestl, Clemens, and University of Zurich

Subjects
10036 Medical Clinic, 610 Medicine & health, 2700 General Medicine, General Medicine
Abstract

Zusammenfassung. Die Betreuung von verletzten Kindern nach Unfällen gehört zum Alltag in einer Kinderarztpraxis und Notfallstation. Zu den häufigsten Verletzungen zählen Rissquetschwunden, vor allem im Kopfbereich, und auch die Zunge kann betroffen sein. Rissquetschwunden der Zunge treten vorwiegend im Kleinkindesalter auf, meistens nach Stolperstürzen, indem sich das Kind mit den Zähnen auf die Zunge beisst. Obwohl diese Verletzungen nicht sehr selten sind, existieren keine evidenzbasierten Therapieempfehlungen. Für Kinder und Familien ist es von grosser Bedeutung, ob ein invasives Vorgehen mit einer primären Wundnaht, meistens in Intubationsnarkose, erforderlich ist oder ob ein konservatives Vorgehen mit sekundärer Wundheilung das gleich gute Ergebnis bringt. In diesem Beitrag zeigen wir auf, wie wir das Zürcher Zungenschema als evidenzbasierte Therapieempfehlung für Kinder mit einfachen Zungenverletzungen entwickelt haben.

Published
2022

26. Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children: a propensity-weighted cohort study

Author

Channon-Wells, Samuel, primary, Vito, Ortensia, additional, McArdle, Andrew J, additional, Seaby, Eleanor G, additional, Patel, Harsita, additional, Shah, Priyen, additional, Pazukhina, Ekaterina, additional, Wilson, Clare, additional, Broderick, Claire, additional, D'Souza, Giselle, additional, Keren, Ilana, additional, Nijman, Ruud G, additional, Tremoulet, Adriana, additional, Munblit, Daniel, additional, Ulloa-Gutierrez, Rolando, additional, Carter, Michael J, additional, Ramnarayan, Padmanabhan, additional, De, Tisham, additional, Hoggart, Clive, additional, Whittaker, Elizabeth, additional, Herberg, Jethro A, additional, Kaforou, Myrsini, additional, Cunnington, Aubrey J, additional, Blyuss, Oleg, additional, Levin, Michael, additional, Chouli, Mohamed, additional, Hamadouche, Nacera, additional, Ladj, Mohamed Samir, additional, Agrimbau Vázquez, Jorge, additional, Carmona, Rodrigo, additional, Collia, Adrian Gustavo, additional, Ellis, Alejandro, additional, Natta, Diego, additional, Pérez, Laura, additional, Rubiños, Mayra, additional, Veliz, Natalia, additional, Yori, Silvana, additional, Britton, Philip N., additional, Burgner, David P., additional, Carey, Emma, additional, Crawford, Nigel W., additional, Giuliano, Hayley, additional, McMinn, Alissa, additional, Wong, Shirley, additional, Wood, Nicholas, additional, Holter, Wolfgang, additional, Krainz, Matthias, additional, Ulreich, Raphael, additional, Zurl, Christoph, additional, Dehoorne, Joke, additional, Haerynck, Filomeen, additional, Hoste, Levi, additional, Schelstraete, Petra, additional, Vandekerckhove, Kristof, additional, Willems, Jef, additional, Almeida Farias, Camila Giuliana, additional, Almeida, Flávia Jacqueline, additional, Alves Leal, Izabel, additional, Araujo da Silva, André Ricardo, additional, Araujo e Silva, Anna Esther, additional, Barreiro, Sabrina T.A., additional, Bomfim Prado da Silva, Daniella Gregória, additional, Cervi, Maria Celia, additional, dos Santos Naja Cardoso, Mirian Viviane, additional, Henriques Teixeira, Cristiane, additional, Jarovsky, Daniel, additional, Martins Araujo, Julienne, additional, Naaman Berezin, Eitan, additional, Palazzi Sáfadi, Marco Aurélio, additional, Paternina-de la Ossa, Rolando Andres, additional, Souza Vieira, Cristina, additional, Dimitrova, Anna, additional, Ganeva, Margarita, additional, Stefanov, Stefan, additional, Telcharova-Mihaylovska, Albena, additional, Biggs, Catherine M., additional, Lopez, Alison, additional, Scuccimarri, Rosie, additional, Tan, Ryan, additional, Wasserman, Sam, additional, Withington, Davinia, additional, Ampuero, Camila, additional, Aravena, Javiera, additional, Bustos B, Raul, additional, Casanova, Daniel, additional, Cruces, Pablo, additional, Diaz, Franco, additional, García-Salum, Tamara, additional, Godoy, Loreto, additional, Medina, Rafael A., additional, Valenzuela Galaz, Gonzalo, additional, Camacho-Moreno, Germán, additional, Avila-Aguero, María L., additional, Brenes-Chacón, Helena, additional, Camacho-Badilla, Kattia, additional, Ivankovich-Escoto, Gabriela, additional, Naranjo-Zuniga, Gabriela, additional, Soriano-Fallas, Alejandra, additional, Yock-Corrales, Adriana, additional, Amer, Maysa Abbas, additional, Abdelmeguid, Yasmine, additional, Ahmed, Yomna H.H.Z., additional, Badib, Adham, additional, Badreldin, Karim, additional, Elkhashab, Yara, additional, Heshmat, Hassan, additional, Hussein, Amna, additional, Mohamed Hussein, Amna Hussein, additional, Ibrahim, Sandra, additional, Shoman, Walaa, additional, Yakout, Radwa M, additional, Heinonen, Santtu, additional, Angoulvant, François, additional, Belot, Alexandre, additional, Ouldali, Naïm, additional, Beske, Florian, additional, Heep, Axel, additional, Masjosthusmann, Katja, additional, Reiter, Karl, additional, van den Heuvel, Ingeborg, additional, von Both, Ulrich, additional, Agrafiotou, Aikaterini, additional, Antachopoulos, Charalampos, additional, Charisi, Konstantina, additional, Eleftheriou, Irini, additional, Farmaki, Evangelia, additional, Fotis, Lampros, additional, Kafetzis, Dimitrios, additional, Koletsi, Patra, additional, Kourtesi, Katerina, additional, Lampidi, Stavroula, additional, Liakopoulou, Theodota, additional, Maritsi, Despoina, additional, Michailidou, Elisa, additional, Milioudi, Maria, additional, Mparmpounaki, Ioanna, additional, Papadimitriou, Eleni, additional, Papaevangelou, Vassiliki, additional, Roilides, Emmanuel, additional, Tsiatsiou, Olga, additional, Tsolas, Georgios, additional, Tsolia, Maria, additional, Vantsi, Petrina, additional, Banegas Pineda, Linda Yajeira, additional, Borjas Aguilar, Karla Leversia, additional, Cantillano Quintero, Edwin Mauricio, additional, Ip, Patrick, additional, Kwan, Mike Yat Wah, additional, Kwok, Janette, additional, Lau, Yu Lung, additional, To, Kelvin, additional, Wong, Joshua Sung Chih, additional, David, Mate, additional, Farkas, David, additional, Kalcakosz, Szofia, additional, Szekeres, Klaudia, additional, Zsigmond, Borbala, additional, Aslam, Nadeem, additional, Luder, Anthony, additional, Andreozzi, Laura, additional, Bianco, Francesco, additional, Bucciarelli, Valentina, additional, Buonsenso, Danilo, additional, Cimaz, Rolando, additional, De Luca, Maia, additional, Dellepiane, Rosa Maria, additional, Fabi, Marianna, additional, Filice, Emanuele, additional, Lanari, Marcello, additional, Lo Vecchio, Andrea, additional, Mastrolia, Maria Vincenza, additional, Mauro, Angela, additional, Mazza, Angelo, additional, Papa, Mario Virgilio, additional, Romani, Lorenza, additional, Scarano, Sara Maria, additional, Simonini, Gabriele, additional, Tipo, Vincenzo, additional, Verdoni, Lucio, additional, Macharia, Anne-Marie, additional, Musiime, Grace, additional, Reel, Bhupi, additional, Wangai, Frederick, additional, Pace, David, additional, Torpiano, Paul, additional, Anaya-Enriquez, Nancy, additional, Carreon-Guerrero, Juan Manuel, additional, Chacon-Cruz, Enrique, additional, Cheung López, Mariana, additional, Faugier Fuentes, Enrique, additional, Fonseca Flores, Marisol, additional, García-Domínguez, Miguel, additional, Giron Vargas, Ana Luisa, additional, Lopez-Delgado, Ivan, additional, Lopez Hernández, Liliana, additional, Menchaca Aguayo, Hector F., additional, Montaño-Duron, Jesus Gilberto, additional, Pérez-Gaxiola, Giordano, additional, Ramos Tiñini, Pamela, additional, Tostado-Morales, Edgardo, additional, Valadez, Julio, additional, Inchley, Christopher, additional, Klevberg, Sjur, additional, Knudsen, Per Kristian, additional, Måseide, Per Helge, additional, Carrera, Jose Manuel, additional, Castaño, Elizabeth, additional, Daza Timana, Carlos Alberto, additional, De Leon, Tirza, additional, Estripeaut, Dora, additional, Levy, Jacqueline, additional, Norero, Ximena, additional, Record, Javier, additional, Rojas-Bonilla, Magda, additional, Wong, Mayra, additional, Iramain, Ricardo, additional, Hernandez, Roger, additional, Huamán, Gian, additional, Munaico, Manuel, additional, Peralta, Carlos, additional, Seminario, Diego, additional, Zapata Yarlequé, Elmer Hans, additional, Gadzinska, Justyna, additional, Ludwikowska, Kamila, additional, Mandziuk, Joanna, additional, Okarska-Napierała, Magdalena, additional, Alacheva, Zalina A., additional, Alexeeva, Ekaterina, additional, Ananin, Petr V., additional, Antsupova, Margarita, additional, Bakradze, Maya D., additional, Berbenyuk, Anna, additional, Bobkova, Polina, additional, Borzakova, Svetlana, additional, Chashchina, Irina L., additional, El-Taravi, Yasmin, additional, Fisenko, Andrey P., additional, Gautier, Marina S., additional, Glazyrina, Anastasia, additional, Gorlenko, Cyrill, additional, Grosheva, Mariia, additional, Kiselev, Herman, additional, Kondrikova, Elena, additional, Korobyants, Evgeniya, additional, Korsunskiy, Anatoliy A., additional, Kovygina, Karina, additional, Krasnaya, Ekaterina, additional, Kurbanova, Seda, additional, Kurdup, Maria K., additional, Mamutova, Anna V., additional, Mazankova, Lyudmila, additional, Mitushin, Ilya L., additional, Nargizyan, Anzhelika, additional, Orlova, Yanina O., additional, Osmanov, Ismail M., additional, Polyakova, Anastasia S., additional, Pushkareva, Anna, additional, Romanova, Olga, additional, Samitova, Elmira, additional, Shvedova, Anastasia, additional, Sologub, Anna, additional, Iakovleva, Ekaterina, additional, Tepaev, Rustem F., additional, Tkacheva, Anna A., additional, Yegiyan, Margarita, additional, Yusupova, Valeriya, additional, Zholobova, Elena, additional, Grasa, Carlos Daniel, additional, Epalza, Cristina, additional, Lopez Segura, Nuria, additional, Martinon-Torres, Federico, additional, Melendo, Susana, additional, Mendez-Echevarria, Ana, additional, Mesa Guzmán, Juan Miguel, additional, Palacios Argueta, Jorge Roberto, additional, Rivero-Calle, Irene, additional, Rivière, Jacques, additional, Rodríguez-González, Moisés, additional, Rojo, Pablo, additional, Sanchez Manubens, Judith, additional, Soler-Palacin, Pere, additional, Soriano-Arandes, Antoni, additional, Tagarro, Alfredo, additional, Villaverde, Serena, additional, Altman, Maria, additional, Brodin, Petter, additional, Horne, AnnaCarin, additional, Palmblad, Karin, additional, Brotschi, Barbara, additional, Meyer Sauteur, Patrick, additional, Pachlopnik Schmid, Jana, additional, Prader, Seraina, additional, Relly, Christa, additional, Schlapbach, Luregn J., additional, Seiler, Michelle, additional, Strasser, Sophie, additional, Trück, Johannes, additional, Weber, Kathrin, additional, Wütz, Daniela, additional, Hamdan, Alaa, additional, Melhem, Ibrahim, additional, Moussa, Ahmed, additional, Dunk, Joke, additional, Ketharanathan, Naomi, additional, Vermont, Clementien, additional, Akyüz Özkan, Esra, additional, Cetin, Benhur Sirvan, additional, Erdeniz, Emine Hafize, additional, Şahin, Irfan Oğuz, additional, Borisova, Galina, additional, Boyarchuk, Oksana, additional, Boychenko, Lidiya, additional, Boyko, Yaryna, additional, Diudenko, Nadiia, additional, Dyvonyak, Olha, additional, Kasiyan, Olexandr, additional, Katerynych, Kostiantyn, additional, Kostyuchenko, Larysa, additional, Mamenko, Marina, additional, Melnyk, Kateryna, additional, Miagka, Nelia, additional, Nazarenko, Liliya, additional, Nezgoda, Iryna, additional, Rykova, Stanislava, additional, Svyst, Olga, additional, Teslenko, Maria, additional, Trykosh, Mykola, additional, Vasilenko, Nataliya, additional, Volokha, Alla, additional, Adams, Charlotte, additional, Akomolafe, Toju, additional, Al-Abadi, Eslam, additional, Alders, Nele, additional, Alifieraki, Styliani, additional, Ansumanu, Hareef, additional, Aston, Emily, additional, Avram, Paula, additional, Bamford, Alasdair, additional, Banks, Millie, additional, Basu Roy, Robin, additional, Beattie, Thomas, additional, Boleti, Olga, additional, Bracken, Abbey, additional, Broad, Jonathan, additional, Cai, James, additional, Carrol, Enitan D., additional, Carter, Michael, additional, Chandran, Anchit, additional, Charlesworth, James, additional, Chawla, Jaya, additional, Cooper, Hannah, additional, Cooray, Samantha, additional, Davies, Patrick, additional, Davis, Francesca, additional, Drysdale, Simon B., additional, Dzora, Ella, additional, Emonts, Marieke, additional, Evans, Ceri, additional, Fidler, Katy, additional, Foster, Caroline, additional, Gong, Chen, additional, Gongrun, Berin, additional, Gonzalez, Carmen, additional, Gorgun, Berin, additional, Grandjean, Louis, additional, Grant, Karlie, additional, Guo, Jonathan, additional, Hacohen, Yael, additional, Hall, Jack, additional, Hamid, Hytham K.S., additional, Hassell, Jane, additional, Hesketh, Christine, additional, Hewlett, Jessica, additional, Hnieno, Ahmad, additional, Holt-Davis, Hannah, additional, Hossain, Aleena, additional, Hu, Shiying, additional, Hudson, Lee D., additional, Jheeta, Sharon, additional, Johnson, Mae, additional, Johnson, Sarah, additional, Jyothish, Deepthi, additional, Kampmann, Beate, additional, Kavirayani, Akhila, additional, Kelly, Deborah, additional, Kirubakaran, Arangan, additional, Kucera, Filip, additional, Langer, Daniel, additional, Lawson, George, additional, Lees, Emily A, additional, Lenihan, Rebecca, additional, Lillie, Jon, additional, Longbottom, Katherine, additional, Lyall, Hermione, additional, Mackdermott, Niamh, additional, Maltby, Sarah, additional, Mclelland, Thomas, additional, McMahon, Anne-Marie, additional, Miller, Danielle, additional, Miranda, Mariana, additional, Mirza, Luwaiza, additional, Morrison, Zoe, additional, Moshal, Karyn, additional, Muller, Jennifer, additional, Musuka, Phoebe, additional, Myttaraki, Evangelia, additional, Nadel, Simon, additional, Nair, Sreedevi, additional, Nuttall, Luke, additional, Oremakinde, Oyinkansola, additional, Osaghae, Daniella, additional, Osman, Fatima, additional, Ostrzewska, Anna, additional, Paccagnella, Davide, additional, Panthula, Mrinalini, additional, Papachatzi, Eleni, additional, Papadopoulou, Charalampia, additional, Patel, Fahim, additional, Payne, Helen, additional, Penner, Justin, additional, Polandi, Shervin, additional, Prendergast, Andrew J., additional, Ranasinghe, Lasith, additional, Ravichandran, Muthukumaran, additional, Rhys-Evans, Sophie, additional, Riordan, Andrew, additional, Rodrigues, Charlene M.C., additional, Roe, Lauren, additional, Romaine, Sam, additional, Schobi, Nina, additional, Seddon, James, additional, Shingadia, Delane, additional, Sikdar, Oishi, additional, Srivastava, Anand, additional, Struik, Siske, additional, Sun, Thomas, additional, Tan, Rachel Wei, additional, Taylor, Alice, additional, Taylor, Amanda, additional, Taylor, Andrew, additional, Tran, Steven, additional, Tsagkaris, Stavros, additional, Tudor-Williams, Gareth, additional, van den Berg, Sarah, additional, van der Velden, Fabian, additional, Ventilacion, Lyn, additional, Wellman, Paul A., additional, Withers Green, Joseph, additional, Yanney, Michael P., additional, Yeung, Shunmay, additional, Badheka, Aditya, additional, Badran, Sarah, additional, Bailey, Dwight M., additional, Burch, Anna Kathryn, additional, Burns, Jane C., additional, Cichon, Catherine, additional, Cirks, Blake, additional, Dallman, Michael D., additional, Delany, Dennis R., additional, Fairchok, Mary, additional, Friedman, Samantha, additional, Geracht, Jennifer, additional, Langs-Barlow, Allison, additional, Mann, Kelly, additional, Padhye, Amruta, additional, Quade, Alexis, additional, Ramirez, Kacy Alyne, additional, Rockett, John, additional, Sayed, Imran Ali, additional, Santos, Roberto P., additional, Shahin, Amr A., additional, Umaru, Samuel, additional, Widener, Rebecca, additional, Mujuru, Hilda Angela, additional, and Kandawasvika, Gwendoline, additional

Published
2023
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27. Methylprednisolone versus intravenous immunoglobulins in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS): an open-label, multicentre, randomised trial

Author

Welzel, Tatjana, primary, Atkinson, Andrew, additional, Schöbi, Nina, additional, Andre, Maya C, additional, Bailey, Douggl G N, additional, Blanchard-Rohner, Geraldine, additional, Buettcher, Michael, additional, Grazioli, Serge, additional, Koehler, Henrik, additional, Perez, Marie-Helene, additional, Trück, Johannes, additional, Vanoni, Federica, additional, Zimmermann, Petra, additional, Sanchez, Carlos, additional, Bielicki, Julia A, additional, Schlapbach, Luregn J, additional, Bieri, Andreas, additional, Gysi, Spyridoula, additional, Janz, Indra, additional, Donner, Birgit, additional, Hammer, Jürg, additional, Heininger, Ulrich, additional, Kohns Vasconcelos, Malte, additional, Mettauer, Nicole, additional, Meyer, Alexandra, additional, Reppucci, Diana, additional, Schlaeppi, Chloé, additional, Trachsel, Daniel, additional, Vaezipour, Nina, additional, von Kalckreuth, Clemens, additional, Woerner, Andreas, additional, Zutter, Andreas, additional, Kottanattu, Lisa, additional, Mazzara, Calogero, additional, Severi Conti, Alessia, additional, Aebi, Christoph, additional, Agyeman, Philipp K A, additional, Duppenthaler, Andrea, additional, Glöckler, Martin, additional, Pallivathukal, Sabine, additional, Riedel, Thomas, additional, Cudré-Cung, Hong-Phuc, additional, Pavlovic, Mladen, additional, Bordessoule, Alice, additional, L'Huillier, Arnaud G, additional, Martin, Anne-Laure, additional, Polito, Angelo, additional, Rohr, Marie, additional, Rodriguez, Maria Isabel, additional, Wagner, Noemie, additional, Chanez, Vivianne, additional, Bressieux-Degueldre, Sabrina, additional, Ferry, Thomas, additional, Hofer, Michael, additional, Longchamp, David, additional, Natterer, Julia, additional, Oppenheim, Rebecca, additional, Donas, Alex, additional, Germann, Sara, additional, Hrup, Katja, additional, Kaiser, Daniela, additional, Kuen, Hans Peter, additional, Lütolf Erni, Michaela, additional, Schwendener Scholl, Katharina, additional, Stritt, Janine, additional, Wechselberger, Katharina, additional, Beck, Ingrid, additional, Birkenmaier, André, additional, Flade, Martin, additional, Rogdo, Bjarte, additional, Iglowstein, Ivo, additional, Lorenz, Philip, additional, Wachinger, Tanja, additional, Zöhrer, Konstanze, additional, Brotschi, Barbara, additional, Meyer Sauteur, Patrick M, additional, Pachlopnik Schmid, Jana, additional, Prader, Seraina, additional, Seiler, Michelle, additional, Weber, Kathrin, additional, Wütz, Daniela, additional, Whittaker, Elizabeth, additional, and Faust, Saul N, additional

Published
2023
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29. Detection of mostly viral pathogens and high proportion of antibiotic treatment initiation in hospitalised children with community-acquired pneumonia in Switzerland – baseline findings from the first two years of the KIDS-STEP trial

Author

Vasconcelos, Malte Kohns, primary, Meyer Sauteur, Patrick M., additional, Keitel, Kristina, additional, Santoro, Regina, additional, Egli, Adrian, additional, Coslovsky, Michael, additional, Seiler, Michelle, additional, Lurà, Marco, additional, Köhler, Henrik, additional, Loevy, Natasha, additional, Kahlert, Christian R., additional, Heininger, Ulrich, additional, Van den Anker, Johannes, additional, and Bielicki, Julia A., additional

Published
2023
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31. Artificial intelligence-based detection of paediatric appendicular skeletal fractures: performance and limitations for common fracture types and locations

Author

Altmann-Schneider, Irmhild; https://orcid.org/0000-0003-2477-5743, Kellenberger, Christian J; https://orcid.org/0000-0001-9122-2431, Pistorius, Sarah-Maria, Saladin, Camilla; https://orcid.org/0000-0003-1232-7927, Schäfer, Deborah, Arslan, Nidanur, Fischer, Hanna L, Seiler, Michelle; https://orcid.org/0000-0002-1263-5818, Altmann-Schneider, Irmhild; https://orcid.org/0000-0003-2477-5743, Kellenberger, Christian J; https://orcid.org/0000-0001-9122-2431, Pistorius, Sarah-Maria, Saladin, Camilla; https://orcid.org/0000-0003-1232-7927, Schäfer, Deborah, Arslan, Nidanur, Fischer, Hanna L, and Seiler, Michelle; https://orcid.org/0000-0002-1263-5818

Abstract

BACKGROUND Research into artificial intelligence (AI)-based fracture detection in children is scarce and has disregarded the detection of indirect fracture signs and dislocations. OBJECTIVE To assess the diagnostic accuracy of an existing AI-tool for the detection of fractures, indirect fracture signs, and dislocations. MATERIALS AND METHODS An AI software, BoneView (Gleamer, Paris, France), was assessed for diagnostic accuracy of fracture detection using paediatric radiology consensus diagnoses as reference. Radiographs from a single emergency department were enrolled retrospectively going back from December 2021, limited to 1,000 radiographs per body part. Enrolment criteria were as follows: suspected fractures of the forearm, lower leg, or elbow; age 0-18 years; and radiographs in at least two projections. RESULTS Lower leg radiographs showed 607 fractures. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were high (87.5%, 87.5%, 98.3%, 98.3%, respectively). Detection rate was low for toddler's fractures, trampoline fractures, and proximal tibial Salter-Harris-II fractures. Forearm radiographs showed 1,137 fractures. Sensitivity, specificity, PPV, and NPV were high (92.9%, 98.1%, 98.4%, 91.7%, respectively). Radial and ulnar bowing fractures were not reliably detected (one out of 11 radial bowing fractures and zero out of seven ulnar bowing fractures were correctly detected). Detection rate was low for styloid process avulsions, proximal radial buckle, and complete olecranon fractures. Elbow radiographs showed 517 fractures. Sensitivity and NPV were moderate (80.5%, 84.7%, respectively). Specificity and PPV were high (94.9%, 93.3%, respectively). For joint effusion, sensitivity, specificity, PPV, and NPV were moderate (85.1%, 85.7%, 89.5%, 80%, respectively). For elbow dislocations, sensitivity and PPV were low (65.8%, 50%, respectively). Specificity and NPV were high (97.7%, 98.8%, respectively). CONCLUSIONS The diag

Published
2023

32. IVIg treatment increases thrombin activation of platelets and thrombin generation in paediatric patients with immune thrombocytopenia

Author

Schmugge, Markus; https://orcid.org/0000-0003-4745-8572, Franzoso, Francesca Daniela; https://orcid.org/0000-0002-1939-376X, Winkler, Jeannine, Kroiss, Sabine, Seiler, Michelle; https://orcid.org/0000-0002-1263-5818, Speer, Oliver, Rand, Margaret L, Schmugge, Markus; https://orcid.org/0000-0003-4745-8572, Franzoso, Francesca Daniela; https://orcid.org/0000-0002-1939-376X, Winkler, Jeannine, Kroiss, Sabine, Seiler, Michelle; https://orcid.org/0000-0002-1263-5818, Speer, Oliver, and Rand, Margaret L

Abstract

Clinical manifestations and laboratory parameters of haemostasis were investigated in 23 children with newly diagnosed immune thrombocytopenia (ITP) before and after intravenous immunoglobulin (IVIg) treatment. ITP patients with platelet counts of less than 20 × 10$^{9}$ /L and mild bleeding symptoms, graded by a standardized bleeding score (BS), were compared with healthy children with normal platelet counts and children with chemotherapy-related thrombocytopenia. Markers of platelet activation and platelet apoptosis in the absence and presence of platelet activators were analysed by flow cytometry; thrombin generation in plasma was determined. ITP patients at diagnosis presented with increased proportions of platelets expressing CD62P and CD63 and activated caspases, and with decreased thrombin generation. Thrombin-induced activation of platelets was reduced in ITP compared with controls, while increased proportions of platelets with activated caspases were observed. Children with a higher BS had lower proportions of CD62P-expressing platelets compared with those with a lower BS. IVIg treatment increased the number of reticulated platelets, the platelet count to more than 20 × 10$^{9}$ /L and improved bleeding in all patients. Decreased thrombin-induced platelet activation, as well as thrombin generation, were ameliorated. Our results indicate that IVIg treatment helps to counteract diminished platelet function and coagulation in children with newly diagnosed ITP.

Published
2023

33. Detection of mostly viral pathogens and high proportion of antibiotic treatment initiation in hospitalised children with community-acquired pneumonia in Switzerland – baseline findings from the first two years of the KIDS-STEP trial

Author

Kohns Vasconcelos, Malte, Meyer Sauteur, Patrick M; https://orcid.org/0000-0002-4312-9803, Keitel, Kristina, Santoro, Regina, Egli, Adrian; https://orcid.org/0000-0002-3564-8603, Coslovsky, Michael; https://orcid.org/0000-0001-7678-7354, Seiler, Michelle; https://orcid.org/0000-0002-1263-5818, Lurà, Marco, Köhler, Henrik, Loevy, Natasha, Kahlert, Christian R; https://orcid.org/0000-0002-0784-3276, Heininger, Ulrich; https://orcid.org/0000-0001-8901-6778, Van den Anker, Johannes, Bielicki, Julia A; https://orcid.org/0000-0002-3902-5489, Kohns Vasconcelos, Malte, Meyer Sauteur, Patrick M; https://orcid.org/0000-0002-4312-9803, Keitel, Kristina, Santoro, Regina, Egli, Adrian; https://orcid.org/0000-0002-3564-8603, Coslovsky, Michael; https://orcid.org/0000-0001-7678-7354, Seiler, Michelle; https://orcid.org/0000-0002-1263-5818, Lurà, Marco, Köhler, Henrik, Loevy, Natasha, Kahlert, Christian R; https://orcid.org/0000-0002-0784-3276, Heininger, Ulrich; https://orcid.org/0000-0001-8901-6778, Van den Anker, Johannes, and Bielicki, Julia A; https://orcid.org/0000-0002-3902-5489

Abstract

AIMS OF THE STUDY: Globally, since the introduction of conjugate-vaccines against encapsulated bacteria, respiratory viruses have caused most hospitalisations for community-acquired pneumonia. The aim of this study was to describe pathogens detected and their association with clinical findings in Switzerland. METHODS: Baseline data were analysed for all trial participants enrolled between September 2018 and September 2020 into the KIDS-STEP Trial, a randomised controlled superiority trial on the effect of betamethasone on clinical stabilisation of children admitted with community-acquired pneumonia. Data included clinical presentation, antibiotic use and results of pathogen detection. In addition to routine sampling, nasopharyngeal specimens were analysed for respiratory pathogens using a panel polymerase chain reaction test covering 18 viral and 4 bacterial pathogens. RESULTS: 138 children with a median age of 3 years were enrolled at the eight trial sites. Fever (obligatory for enrolment) had been present for median 5 days before admission. Most common symptoms were reduced activity (129, 93.5%) and reduced oral intake (108, 78.3%). Oxygen saturation <92% was found in 43 (31.2%). Forty-three participants (29.0%) were already on antibiotic treatment prior to admission and 104 participants (75.4%) received antibiotic treatment on admission. Pathogen testing results were available from 132 children: 31 (23.5%) had respiratory syncytial virus detected, 21 (15.9%) human metapneumovirus. The pathogens detected showed expected seasonal and age preponderance and were not associated with chest X-ray findings. CONCLUSIONS: In the context of the predominantly viral pathogens detected, the majority of antibiotic treatment is probably unnecessary. The ongoing trial, as well as other studies, will be able to provide comparative pathogen detection data to compare pre- and post-COVID-19-pandemic settings.

Published
2023

34. Analytical description of adolescent binge drinking patients

Author

Haas, Cordula; https://orcid.org/0000-0001-8122-1427, Salzmann, Andrea Patrizia, Binz, Tina Maria; https://orcid.org/0000-0001-6783-1202, Staubli, Georg; https://orcid.org/0000-0003-2667-1972, Seiler, Michelle; https://orcid.org/0000-0002-1263-5818, Steuer, Andrea Eva; https://orcid.org/0000-0001-8983-2353, Haas, Cordula; https://orcid.org/0000-0001-8122-1427, Salzmann, Andrea Patrizia, Binz, Tina Maria; https://orcid.org/0000-0001-6783-1202, Staubli, Georg; https://orcid.org/0000-0003-2667-1972, Seiler, Michelle; https://orcid.org/0000-0002-1263-5818, and Steuer, Andrea Eva; https://orcid.org/0000-0001-8983-2353

Abstract

Background Binge drinking is a widespread health compromising behavior among adolescents and young adults, leading to significant health problems, injuries and mortality. However, data on alcohol consumption is often unreliable, as it is mainly based on self-reporting surveys. In this five-year study (2014–2019) at the University Children’s Hospital Zurich, we analyzed blood samples from adolescent binge drinking patients to investigate blood alcohol concentrations (BACs), co-ingestion of drugs, assess compliance between self-reported and measured substance use, and test for genetic components of innate alcohol tolerance. Furthermore, hair analysis was performed to retrospectively access drug exposure and to evaluate the potential of hair analysis to assess binge drinking. Methods In a prospective, single-center study, patients with alcohol intoxications aged 16 years and younger were included. Blood and hair samples were analyzed by sensitive liquid chromatography – tandem mass spectrometry drug analysis. HTTLPR genotyping was performed with PCR and fragment analysis. Results Among 72 cases, 72 blood and 13 hair samples were analyzed. BACs ranged from 0.08–3.20‰ (mean 1.63‰, median 1.60‰), while a mean concentration of 3.64 pg/mg hair (median 3.0 pg/mg) of the alcohol marker ethyl glucuronide (EtG) was detected in eleven hair samples, providing no evidence of chronic excessive drinking. In 47% of the cases, co-ingested drugs were qualitatively detected next to ethanol, but only 9% of the detected drugs had blood concentrations classified as pharmacologically active. Cannabis consumption (22%) and stimulant intake (16%) were the most frequently observed drugs. Compliance between patients’ statements and measured substances matched well. Although we investigated the genetic contribution to innate alcohol tolerance via the 5-HTTLPR polymorphism, the diverse genetic background of the cohort and small sample size did not allow any conclusions to be drawn. Conclusion Alm

Published
2023

35. Paediatric fractures of carpal bones other than the scaphoid

Author

Weber, Daniel Max; https://orcid.org/0000-0001-5027-2985, Kraus, Ralf, Wirth-Welle, Ruth, Andreisek, Gustav, Gnannt, Ralph; https://orcid.org/0000-0001-8120-6200, Guéro, Stéphane, Neeser, Hannah R, Seiler, Michelle; https://orcid.org/0000-0002-1263-5818, Weber, Daniel Max; https://orcid.org/0000-0001-5027-2985, Kraus, Ralf, Wirth-Welle, Ruth, Andreisek, Gustav, Gnannt, Ralph; https://orcid.org/0000-0001-8120-6200, Guéro, Stéphane, Neeser, Hannah R, and Seiler, Michelle; https://orcid.org/0000-0002-1263-5818

Abstract

OBJECTIVES Fractures of carpal bones other than the scaphoid are rare in children. The aim of this study was to analyze results and identify risk factors for an unfavorable outcome. MATERIAL AND METHODS Children and adolescents up to the age of 16 years who sustained a carpal fracture other than in the scaphoid between 2004 and 2021 were reviewed in this single-center retrospective study. RESULTS In a series of 209 children and adolescents with carpal fractures, 22 had fractures other than the scaphoid. Mean age was 13 years (range 8-16) years, with a total of 41 fractures, with highest incidences for the capitate (10), trapezium (6), triquetrum (4) and pisiform (4). Twenty-nine of these 41 fractures were missed on initial X-ray. Non-displaced fractures were treated with a short arm spica cast including the thumb. Four patients were operated on for displacement fracture or carpometacarpal subluxation. All fractures united, and patients returned to full activities. At the final consultation at a median 14 months (range 6-89) post-injury, all patients with non-displaced fractures were free of symptoms, with excellent Mayo Wrist Scores (MWS). However, three patients with operated trapezium fractures developed early radiological signs of osteoarthritis, two of them with residual pain and MWS rated only good. CONCLUSION Non-displaced pediatric carpal fractures treated by forearm cast have excellent prognosis. Fractures of the trapezium with displacement or first carpometacarpal subluxation incur a risk of osteoarthritis despite anatomical reduction and internal fixation.

Published
2023

38. Caregiver willingness to vaccinate their children against COVID-19: Cross sectional survey

Author

Goldman, Ran D, Yan, Tyler D, Seiler, Michelle, Parra Cotanda, Cristina, Brown, Julie C, Klein, Eileen J, Hoeffe, Julia, Gelernter, Renana, Hall, Jeanine E, Davis, Adrienne L, Griffiths, Mark A, Mater, Ahmed, Manzano, Sergio, Gualco, Gianluca, Shimizu, Naoki, Hurt, Thomas L, Ahmed, Sara, Hansen, Matt, Sheridan, David, Ali, Samina, Thompson, Graham C, Gaucher, Nathalie, Staubli, Georg, and International COVID-19 Parental Attitude Study (COVIPAS) Group

Subjects
Immunity, Herd, Male, Vaccination Coverage, Coronavirus Infections/economics/epidemiology/immunology/prevention & control/virology, Vaccination schedule, Cross-sectional study, International Cooperation, Viral Vaccines/biosynthesis/economics, North America/epidemiology, 0302 clinical medicine, Japan, Vaccination Refusal, Pandemic, Medicine, 030212 general & internal medicine, Pandemics/prevention & control, Israel, Child, Emergency Service, education.field_of_study, ddc:618, Vaccination, Betacoronavirus/immunology/pathogenicity, Japan/epidemiology, Europe, Infectious Diseases, Molecular Medicine, Female, Coronavirus Infections, Emergency Service, Hospital, Vaccination Refusal/psychology/statistics & numerical data, Adult, medicine.medical_specialty, COVID-19 Vaccines, Pneumonia, Viral, Population, Article, Europe/epidemiology, Herd immunity, Vaccination/psychology, Hospital, Betacoronavirus, 03 medical and health sciences, 030225 pediatrics, Humans, education, Pandemics, Israel/epidemiology, General Veterinary, General Immunology and Microbiology, SARS-CoV-2, business.industry, Public health, Immunity, Public Health, Environmental and Occupational Health, COVID-19, Viral Vaccines, Pneumonia, Emergency Department, Emergency department, Herd, Vaccination Coverage/statistics & numerical data, Coronavirus, Cross-Sectional Studies, Family medicine, Multivariate Analysis, North America, Viral/epidemiology/immunology/prevention & control/virology, business
Abstract

Highlights • About two thirds of caregivers intend to vaccinate their children against COVID-19. • Most common reason for acceptance was to protect the child. • Most common reason for refusal was the vaccine’s novelty. • Child age, chronic illness, vaccination history affects willingness. • Caregiver gender, vaccination history, concern about infection affect willingness., Background More than 100 COVID-19 vaccine candidates are in development since the SARS-CoV-2 genetic sequence was published in January 2020. The uptake of a COVID-19 vaccine among children will be instrumental in limiting the spread of the disease as herd immunity may require vaccine coverage of up to 80% of the population. Prior history of pandemic vaccine coverage was as low as 40% among children in the United States during the 2009 H1N1 influenza pandemic. Purpose To investigate predictors associated with global caregivers’ intent to vaccinate their children against COVID-19, when the vaccine becomes available. Method An international cross sectional survey of 1541 caregivers arriving with their children to 16 pediatric Emergency Departments (ED) across six countries from March 26 to May 31, 2020. Results 65% (n = 1005) of caregivers reported that they intend to vaccinate their child against COVID-19, once a vaccine is available. A univariate and subsequent multivariate analysis found that increased intended uptake was associated with children that were older, children with no chronic illness, when fathers completed the survey, children up-to-date on their vaccination schedule, recent history of vaccination against influenza, and caregivers concerned their child had COVID-19 at the time of survey completion in the ED. The most common reason reported by caregivers intending to vaccinate was to protect their child (62%), and the most common reason reported by caregivers refusing vaccination was the vaccine’s novelty (52%). Conclusions The majority of caregivers intend to vaccinate their children against COVID-19, though uptake will likely be associated with specific factors such as child and caregiver demographics and vaccination history. Public health strategies need to address barriers to uptake by providing evidence about an upcoming COVID-19 vaccine’s safety and efficacy, highlighting the risks and consequences of infection in children, and educating caregivers on the role of vaccination.

Published
2020

39. Should COVID-19 vaccines be mandated in schools? - an international caregiver perspective

Author

Baumer-Mouradian, Shannon H; https://orcid.org/0000-0002-0878-5119, Hart, Rebecca J, Bone, Jeffrey N, Seiler, Michelle; https://orcid.org/0000-0002-1263-5818, Olson, Prasra, Keitel, Kristina, Manzano, Sergio, Gualco, Gianluca, Krupik, Danna, Schroter, Stephanie, Weigert, Rachel M, Chung, SunHee, Thompson, Graham C, Muhammad, Nina, Shah, Pareen, Gaucher, Nathalie O, Lunoe, Maren M, Evers, Megan, Pharisa Rochat, Cosette, Nelson, Courtney E, Shefler Gal, Moran, Doucas, Adrianna, Goldman, Ran D, Baumer-Mouradian, Shannon H; https://orcid.org/0000-0002-0878-5119, Hart, Rebecca J, Bone, Jeffrey N, Seiler, Michelle; https://orcid.org/0000-0002-1263-5818, Olson, Prasra, Keitel, Kristina, Manzano, Sergio, Gualco, Gianluca, Krupik, Danna, Schroter, Stephanie, Weigert, Rachel M, Chung, SunHee, Thompson, Graham C, Muhammad, Nina, Shah, Pareen, Gaucher, Nathalie O, Lunoe, Maren M, Evers, Megan, Pharisa Rochat, Cosette, Nelson, Courtney E, Shefler Gal, Moran, Doucas, Adrianna, and Goldman, Ran D

Abstract

Objectives: Caregiver attitudes toward mandating COVID-19 vaccines for their children are poorly understood. We aimed to determine caregiver acceptability of COVID-19 vaccine mandates for schools/daycares and assess if opposition to mandates would result in removal of children from the educational system. Study design: Perform a cross-sectional, anonymous survey of adult caregivers with children ≤ 18 years presenting to 21 pediatric emergency departments in the United States, Canada, Israel, and Switzerland, November 1st through December 31st, 2021. The primary outcome was caregiver acceptance rates for school vaccine mandates, and the secondary outcomes included factors associated with mandate acceptance and caregiver intention to remove the child from school. Results: Of 4,393 completed surveys, 37% of caregivers were opposed to any school vaccine mandate. Caregiver acceptance was lowest for daycare settings (33%) and increased as the child's level of education increased, college (55%). 26% of caregivers report a high likelihood (score of 8-10 on 0-10 scale) to remove their child from school if the vaccine became mandatory. Child safety was caregivers' greatest concern over vaccine mandates. A multivariable model demonstrated intent to vaccinate their child for COVID-19 (OR = 8.9, 95% CI 7.3 to 10.8; P < 0.001) and prior COVID-19 vaccination for the caregiver (OR = 3.8, 95% CI 3.0 to 4.9; P < 0.001) had the greatest odds of increasing mandate acceptance for any school level. Conclusions: Many caregivers are resistant to COVID-19 vaccine mandates for schools, and acceptance varies with school level. One-fourth of caregivers plan to remove their child from the educational system if vaccines become mandated

Published
2022

40. Factors associated with unvaccinated caregivers who plan to vaccinate their children

Author

Goldman, R D, Seiler, Michelle; https://orcid.org/0000-0002-1263-5818, Olson, P G, Hart, R J, Bone, J N, Baumer-Mouradian, S H, Goldman, R D, Seiler, Michelle; https://orcid.org/0000-0002-1263-5818, Olson, P G, Hart, R J, Bone, J N, and Baumer-Mouradian, S H

Abstract

Vaccine hesitancy is complex and a threat to global public health during the ongoing COVID-19 pandemic. Our objective was to determine factors associated with caregivers' willingness to vaccinate children despite not being immunized themselves against COVID-19. The International COVID-19 Parental Attitude Study (COVIPAS), a multinational cohort study, recruited caregivers of children 0-18 years old in 21 Emergency Departments (EDs) in USA, Canada, Israel, and Switzerland during November-December 2021. Of a total of 4536 caregivers who completed the survey, 882 (19.4%) were unvaccinated, and 62 (7.0%) of the unvaccinated planned to vaccinate their children. Unvaccinated caregivers with children that had their childhood vaccines up-to-date (OR 3.03 (1.36, 8.09), p = 0.01), and those very worried their child has COVID-19 in the ED (OR 3.11 (1.44, 6.34), p < 0.01) were much more likely to plan to immunize their children. Primary care providers and public health agencies should not assume that unvaccinated parents will not vaccinate their children. Determining child's vaccination status and parental level of concern about COVID-19 may help identify caregivers who are open to give their children the vaccine. Keywords: COVID-19; Sars-cov-2; Unvaccinated; Vaccination; Vaccine hesitancy.

Published
2022

43. Metabolomics analysis of antiquitin deficiency in cultured human cells and plasma: Relevance to pyridoxine‐dependent epilepsy.

Author

Crowther, Lisa M., Poms, Martin, Zandl‐Lang, Martina, Abela, Lucia, Hartmann, Hans, Seiler, Michelle, Mathis, Déborah, and Plecko, Barbara

Abstract

Deficiency of antiquitin (α‐aminoadipic semialdehyde dehydrogenase), an enzyme involved in lysine degradation and encoded by ALDH7A1, is the major cause of vitamin B6‐dependent epilepsy (PDE‐ALDH7A1). Despite seizure control with high dose pyridoxine (PN), developmental delay still occurs in approximately 70% of patients. We aimed to investigate metabolic perturbations due to possible previously unidentified roles of antiquitin, which may contribute to developmental delay, as well as metabolic effects of high dose pyridoxine supplementation reflecting the high doses used for seizure control in patients with PDE‐ALDH7A1. Untargeted metabolomics by high resolution mass spectrometry (HRMS) was used to analyze plasma of patients with PDE‐ALDH7A1 and two independently generated lines of cultured ReNcell CX human neuronal progenitor cells (NPCs) with CRISPR/Cas mediated antiquitin deficiency. Accumulation of lysine pathway metabolites in antiquitin‐deficient NPCs and western‐blot analysis confirmed knockdown of ALDH7A1. Metabolomics analysis of antiquitin‐deficient NPCs in conditions of lysine restriction and PN supplementation identified changes in metabolites related to the transmethylation and transsulfuration pathways and osmolytes, indicating a possible unrecognized role of antiquitin outside the lysine degradation pathway. Analysis of plasma samples of PN treated patients with PDE‐ALDH7A1 and antiquitin‐deficient NPCs cultured in conditions comparable to the patient plasma samples demonstrated perturbation of metabolites of the gamma‐glutamyl cycle, suggesting potential oxidative stress‐related effects in PN‐treated patients with PDE‐ALDH7A1. We postulate that a model of human NPCs with CRISPR/Cas mediated antiquitin deficiency is well suited to characterize previously unreported roles of antiquitin, relevant to this most prevalent form of pyridoxine‐dependent epilepsy. [ABSTRACT FROM AUTHOR]

Published
2023
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44. Nitrous Oxide 70% for Procedural Analgosedation in a Pediatric Emergency Department With or Without Intranasal Fentanyl?: Analgesic Efficacy and Adverse Events if Combined With Intranasal Fentanyl

Author

Seiler, Michelle, Landolt, Markus A, Staubli, Georg, University of Zurich, and Seiler, Michelle

Subjects
and Child Health, 10036 Medical Clinic, 10093 Institute of Psychology, Emergency Medicine, 2735 Pediatrics, Perinatology and Child Health, General Medicine, 150 Psychology, 2711 Emergency Medicine, Pediatrics, Perinatology
Published
2019

45. Inguinal lymphadenopathy in a teenager

Author

Meyer Sauteur, Patrick M, Seiler, Michelle, Berger, Christoph, and University of Zurich

Subjects
10036 Medical Clinic, 610 Medicine & health
Published
2021

46. 29 Caregiver-Reported Delay in Presentation to Pediatric Emergency Departments for Fear of Contracting COVID-19: A multinational cross-sectional study

Author

Davis, Adrienne, primary, Sunderji, Alia, additional, Marneni, Shashidhar, additional, Seiler, Michelle, additional, Hall, Jeanine, additional, Cotanda, Cristina Parra, additional, Klein, Eileen, additional, Brown, Julie, additional, Gelernter, Renana, additional, Griffiths, Mark, additional, Hoeffe, Julia, additional, Gualco, Gianluca, additional, Mater, Ahmed, additional, Manzano, Sergio, additional, Thompson, Graham, additional, Ahmed, Sara, additional, Ali, Samina, additional, and Goldman, Ran, additional

Published
2021
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47. Gentamicin Population Pharmacokinetics in Pediatric Patients—A Prospective Study with Data Analysis Using the saemix Package in R

Author

Paioni, Paolo, primary, Jäggi, Vera F., additional, Tilen, Romy, additional, Seiler, Michelle, additional, Baumann, Philipp, additional, Bräm, Dominic S., additional, Jetzer, Carole, additional, Haid, Robin T. U., additional, Goetschi, Aljoscha N., additional, Goers, Roland, additional, Müller, Daniel, additional, Coman Schmid, Diana, additional, Meyer zu Schwabedissen, Henriette E., additional, Rinn, Bernd, additional, Berger, Christoph, additional, and Krämer, Stefanie D., additional

Published
2021
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50. Gentamicin Population Pharmacokinetics in Pediatric Patients—A Prospective Study with Data Analysis Using the saemix Package in R

Author

Paioni, Paolo, Jäggi, Vera F, Tilen, Romy, Seiler, Michelle, Baumann, Philipp, Bräm, Dominic S, Jetzer, Carole, Haid, Robin T U, Goetschi, Aljoscha N, Goers, Roland, Müller, Daniel, Coman Schmid, Diana, Meyer zu Schwabedissen, Henriette E, Rinn, Bernd, Berger, Christoph, Krämer, Stefanie D, University of Zurich, Paioni, Paolo, Berger, Christoph, and Krämer, Stefanie D

Subjects
dosing regimen, gentamicin, non-linear mixed-effects modeling, open-source, population pharmacokinetics, saemix, R-project, 3003 Pharmaceutical Science, 610 Medicine & health, Article, RS1-441, Pharmacy and materia medica, 10036 Medical Clinic, 10038 Institute of Clinical Chemistry
Abstract

The aminoglycoside gentamicin is used for the empirical treatment of pediatric infections. It has a narrow therapeutic window. In this prospective study at University Children’s Hospital Zurich, Switzerland, we aimed to characterize the pharmacokinetics of gentamicin in pediatric patients and predict plasma concentrations at typical recommended doses. We recruited 109 patients aged from 1 day to 14 years, receiving gentamicin (7.5 mg/kg at age ≥ 7 d or 5 mg/kg). Plasma levels were determined 30 min, 4 h and 24 h after the infusion was stopped and then transferred, together with patient data, to the secure BioMedIT node Leonhard Med. Population pharmacokinetic modeling was performed with the open-source R package saemix on the SwissPKcdw platform in Leonhard Med. Data followed a two-compartment model. Bodyweight, plasma creatinine and urea were identified as covariates for clearance, with bodyweight as a covariate for central and peripheral volumes of distribution. Simulations with 7.5 mg/kg revealed a 95% CI of 13.0–21.2 mg/L plasma concentration at 30 min after the stopping of a 30-min infusion. At 24 h, 95% of simulated plasma levels were, Pharmaceutics, 13 (10)

Published
2021
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