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3. Pharmacogenomics education, research and clinical implementation in the state of Minnesota

Author

Bishop, Jeffrey R, primary, Huang, R Stephanie, additional, Brown, Jacob T, additional, Mroz, Pawel, additional, Johnson, Steven G, additional, Allen, Josiah D, additional, Bielinski, Suzette J, additional, England, Julie, additional, Farley, Joel F, additional, Gregornik, David, additional, Giri, Jyothsna, additional, Kroger, Christine, additional, Long, Susie E, additional, Luczak, Tiana, additional, McGonagle, Erin J, additional, Ma, Sisi, additional, Matey, Eric T, additional, Mandic, Pinar K, additional, Moyer, Ann M, additional, Nicholson, Wayne T, additional, Petry, Natasha, additional, Pawloski, Pamala A, additional, Schlichte, Allyson, additional, Schondelmeyer, Stephen W, additional, Seifert, Randall D, additional, Speedie, Marilyn K, additional, Stenehjem, David, additional, Straka, Robert J, additional, Wachtl, Jason, additional, Waring, Stephen C, additional, Ness, Brian Van, additional, Zierhut, Heather A, additional, Aliferis, Constantin, additional, Wolf, Susan M, additional, McCarty, Catherine A, additional, and Jacobson, Pamala A, additional

Published
2021
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17. Therapeutic Drug Monitoring: Psychotropic Drugs.

Author

Seifert, Randall D.

Abstract

The therapeutic monitoring of patients who take antipsychotic drugs can be both challenging and rewarding. Antipsychotics have been in clinical use for over 30 years; yet, their complex pharmacology is not fully understood and parallels our infant knowledge of human brain chemistry. The art of successful therapeutic drug monitoring depends on the clinician's knowledge of basic pharmacology, an understanding of psychiatric disorders, and a sensitivity for careful patient observation. In addition, a thorough history, well thought out goals, and reasonable recovery expectations are essential. Antipsychotic drugs are never curative and should be used judiciously for indications where positive results outweigh the risks of adverse effects. This article will provide the reader with sound, practical knowledge of how to monitor these drugs in any clinical setting. © 1989 by W.B. Saunders Company. [ABSTRACT FROM PUBLISHER]

Published
1989
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20. Effect of Sucralfate on the Absorption and Pharmacokinetics of Chlorpropamide.

Author

Letendre, Peter W., Carlson, James D., Seifert, Randall D., Dietz, Albert J., and Dimmit, Dan

Abstract

This study compared the pharmacokinetics of chlorpropamide (C) when administered alone, or in combination with sucralfate (S) to evaluate whether a drug-drug interaction exists between these two agents in vivo. A two-way, randomized, cross-over study was performed in 12 healthy male volunteers who received 250 mg C alone or were pretreated with S qid for two days and then received a single 250-mg dose of C with S on day 3 and continued to take sucralfate throughout the day while serial blood samples were drawn. High-performance liquid chromatography determination of plasma concentrations found there to be no statistically significant differences in maximum concentration, time to maximum concentration, elimination rate constant, or area under the concentration-time curve from 0 to 96 hours. However, there was a statistically significant difference in the area under the curve from 0 to infinity data (P < .05). The authors conclude that there appears to be no drug interaction between sucralfate and chlorpropamide when given concurrently; however, a trend towards less drug availability was seen that may warrant a future multiple-dose study to further evaluate the significance of this finding. [ABSTRACT FROM AUTHOR]

Published
1986
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23. Heparininduced thrombocytopenia in patients with cerebrovascular ischemic disease

Author

Ramirez-Lassepas, Manuel, Cipolle, Robert J., Rodvold, Keith A., Seifert, Randall D., Strand, Linda, Taddeini, Luigi, and Cusulos, Marsha

Abstract

We studied 137 patients who were treated with heparin for cerebral infarction (73), partially reversible ischemic neurologic deficit (22), or transient ischemic attack (42). Platelet counts were performed before therapy, twice weekly, and at cessation of therapy. Platelets decreased in 118 patients (86). In 21 (15.3), platelets dropped ≥40; 9 of 14 new ischemic events and three of six deaths occurred in this group of patients. Because there was a significant association between poor outcome and platelet drop ≥40 (p< 0.001), we believe that platelets should be monitored frequently when patients are treated with heparin for ischemic cerebrovascular disease.

Published
1984

24. Hospital Acquired GramNegative Pneumonias

Author

Cipolle, Robert J., Seifert, Randall D., Zaske, Darwin E., and Strate, Richard G.

Abstract

Individualized tobramycin therapy was systematically evaluated in 26 patients with gramnegative pneumonias involving Pseudomonas aeruginosaand other multiple antibioticresistant pathogens. Patient prognoses were classified by underlying diseases, and response was determined according to previously established criteria. Twentythree patients 88, including all 11 cases involving multiple antibioticresistant pathogens and 12 of 15 cases involving Pseudomonas aeruginosa, successfully responded to individualized tobramycin therapy. Tobramycin daily dosages and pharmacokinetic parameters demonstrated a wide interpatient variability. Measured peak and trough serum concentrations resulting from individualized dosage regimens trough serum concentrations resulting from individualized dosage regimens closely matched desired peak and trough concentrations. Clinical ototoxicity or nephrotoxicity were not observed. Individualizing dosage regimens was an important factor in obtaining therapeutic serum concentrations that may influence treatment response to tobramycin therapy.

Published
1980

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