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7. Serum lipoprotein composition and vitamin D metabolite levels in clinically isolated syndromes: Results from a multi-center study

Author

Browne, Richard W., Weinstock-Guttman, Bianca, Zivadinov, Robert, Horakova, Dana, Bodziak, Mary Lou, Tamaño-Blanco, Miriam, Badgett, Darlene, Tyblova, Michaela, Vaneckova, Manuela, Seidl, Zdenek, Krasensky, Jan, Bergsland, Niels, Ramasamy, Deepa P., Hagemeier, Jesper, Qu, Jun, Havrdova, Eva, and Ramanathan, Murali

Published
2014
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21. Lipid profiles are associated with lesion formation over 24 months in interferon-β treated patients following the first demyelinating event

Author

Weinstock-Guttman, Bianca, Zivadinov, Robert, Horakova, Dana, Havrdova, Eva, Qu, Jun, Shyh, Grace, Lakota, Elizabeth, OʼConnor, Kerri, Badgett, Darlene, Tamaño-Blanco, Miriam, Tyblova, Michaela, Hussein, Sara, Bergsland, Niels, Willis, Laura, Krasensky, Jan, Vaneckova, Manuela, Seidl, Zdenek, and Ramanathan, Murali

Published
2013
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22. Efficiency of 123I-ioflupane SPECT as the marker of basal ganglia damage in acute methanol poisoning: 6-year prospective study

Author

Kotikova, Katerina, primary, Zogala, David, additional, Ptacnik, Vaclav, additional, Trnka, Jiri, additional, Kupka, Karel, additional, Vaneckova, Manuela, additional, Seidl, Zdenek, additional, Diblik, Pavel, additional, Heissigerova, Jarmila, additional, Navratil, Tomas, additional, Komarc, Martin, additional, Zak, Ivan, additional, Polakova, Kamila, additional, Brozova, Hana, additional, and Zakharov, Sergey, additional

Published
2020
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23. Efficiency of 123I-ioflupane SPECT as a marker of basal ganglia damage in acute methanol poisoning: a six-year prospective study

Author

Kotikova, Katerina, primary, Zogala, David, additional, Ptacnik, Vaclav, additional, Trnka, Jiri, additional, Kupka, Karel, additional, Vaneckova, Manuela, additional, Seidl, Zdenek, additional, Diblik, Pavel, additional, Heissigerova, Jarmila, additional, Zak, Ivan, additional, Navratil, Tomas, additional, Komarc, Martin, additional, and Zakharov, Sergey, additional

Published
2020
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24. Health-related quality of life determinants in survivors of a mass methanol poisoning outbreak: six-year prospective cohort study

Author

Rulisek, Jan, primary, Waldauf, Petr, additional, Belohlavek, Jan, additional, Balik, Martin, additional, Kotikova, Katerina, additional, Hlusicka, Jiri, additional, Vaneckova, Manuela, additional, Seidl, Zdenek, additional, Diblik, Pavel, additional, Bydzovsky, Jan, additional, Heissigerova, Jarmila, additional, Urban, Pavel, additional, Miovsky, Michal, additional, Sejvl, Jaroslav, additional, Pelclova, Daniela, additional, and Zakharov, Sergey, additional

Published
2020
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25. The impact of co-morbidities on a 6-year survival after methanol mass poisoning outbreak: possible role of metabolic formaldehyde

Author

Zakharov, Sergey, primary, Rulisek, Jan, additional, Hlusicka, Jiri, additional, Kotikova, Katerina, additional, Navratil, Tomas, additional, Komarc, Martin, additional, Vaneckova, Manuela, additional, Seidl, Zdenek, additional, Diblik, Pavel, additional, Bydzovsky, Jan, additional, Heissigerova, Jarmila, additional, Zogala, David, additional, Hubacek, Jaroslav A., additional, Miovsky, Michal, additional, Sejvl, Jaroslav, additional, Vojtova, Lucie, additional, and Pelclova, Daniela, additional

Published
2019
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26. Monitoring of Subclinical Disease Activity by Serum Neurofilament Light Chain Levels in Multiple Sclerosis (S37.005)

Author

Uher, Tomas, primary, Schaedelin, Sabine, additional, Benova, Barbora, additional, Barro, Christian, additional, Bergsland, Niels, additional, Dwyer, Michael, additional, Tyblova, Michaela, additional, Kucerova, Karolina, additional, Benkert, Pascal, additional, Michalak, Zuzanna, additional, Leppert, David, additional, Naegelin, Yvonne, additional, Krasensky, Jan, additional, Seidl, Zdenek, additional, Vaneckova, Manuela, additional, Havrdova, Eva Kubala, additional, Kappos, Ludwig, additional, Zivadinov, Robert, additional, Horakova, Dana, additional, Kuhle, Jens, additional, and Kalincik, Tomas, additional

Published
2019
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27. Efficiency of 123I-ioflupane SPECT as the marker of basal ganglia damage in acute methanol poisoning: 6-year prospective study.

Author

Kotikova, Katerina, Zogala, David, Ptacnik, Vaclav, Trnka, Jiri, Kupka, Karel, Vaneckova, Manuela, Seidl, Zdenek, Diblik, Pavel, Heissigerova, Jarmila, Navratil, Tomas, Komarc, Martin, Zak, Ivan, Polakova, Kamila, Brozova, Hana, and Zakharov, Sergey

Subjects
BASAL ganglia, SINGLE-photon emission computed tomography, CAUDATE nucleus, POISONING, CREATININE, LONGITUDINAL method, LACTATES
Abstract

Investigate whether 123I-ioflupane SPECT (DaT SPECT) has the potential as a marker of basal ganglia damage in acute methanol poisoning. Prospective, single-centre, cohort study of patients with confirmed methanol poisoning was conducted. DaT SPECT was performed twice with semi-quantification using DaTQUANTTM and MRI-based volumetry was calculated. Specific binding ratios (SBR) of striatum, caudate nucleus, and putamen were correlated with laboratory parameters of outcome, volumetric data, and retinal nerve fibres layer (RNFL) thickness measurements. Forty-two patients (mean age 46.3 ± 4.2 years; 8 females), including 15 with MRI-detected putamen lesions (group I) and 27 patients with intact putamen (group II), underwent DaT SPECT. Volumetry was calculated in 35 of the patients assessed. SBR values for the left putamen correlated with putamen volume (r = 0.665; p < 0.001). Decreased bilateral SBR values were determined for the striatum and the putamen, but not for the nucleus caudate, in group I (p < 0.05). Significant correlation was observed between the SBR of the posterior putamen and arterial blood pH (r = 0.574; p < 0.001) and other toxicological parameters of severity of poisoning/outcome including serum lactate, glucose, and creatinine concentrations (p < 0.05). The SBR of the posterior putamen positively correlated with the global RNFL thickness (p < 0.05). ROC analysis demonstrated a significant discriminatory ability of SBR of the posterior putamen with AUC = 0.753 (95%CI 0.604–0.902; p = 0.007). The multivariate regression model demonstrated that arterial blood pH, age, and gender were the most significant factors associated with SBR of the posterior putamen. DaT SPECT demonstrates significant potential for the diagnosis of methanol-induced basal ganglia damage. [ABSTRACT FROM AUTHOR]

Published
2021
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28. Hemiparetic forms of cerebral palsy in relation to epilepsy and mental retardation

Author

Sussova, Jana, Seidl, Zdenek, and Faber, Josef

Subjects
Cerebral palsy -- Physiological aspects, Hemiplegia -- Physiological aspects, Cerebral dominance -- Physiological aspects, Health
Abstract

The range of symptoms observed among patients with cerebral palsy includes paralysis of one side of the body (hemiparesis), mental retardation, and epileptic seizures. In addition, many patients with cerebral palsy have changes resembling epileptic changes detected by electroencephalography (EEG). However, some researchers have cautioned that these changes may not be directly comparable with those seen in epileptic patients. An evaluation of 51 children with cerebral palsy and hemiparesis was conducted to determine the interrelationships between hemiparesis, mental retardation, and epileptic activity. Boys outnumbered girls over two to one, which is consistent with previous findings of hemiparesis in cerebral palsy. Right-side involvement was more common than left, which was also consistent with other research in the field. (These observations have been attributed to later development of the dominant left hemisphere in most people, and the increased vulnerability of male brains to insult during development.) Seizure activity correlated with lower IQ; otherwise, there seemed to be no relationship between the hemiparesis or abnormal EEG findings, and mental development. Epileptic abnormalities on EEG examination were more common among patients with left-sided hemiparesis. The results suggest that epileptic abnormalities associated with cerebral palsy patients who do not have clinical seizures represent a different patient profile and carry different clinical significance than when similar abnormalities are seen in patients who do have seizures. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1990

29. The impact of co-morbidities on a 6-year survival after methanol mass poisoning outbreak: possible role of metabolic formaldehyde.

Author

Zakharov, Sergey, Rulisek, Jan, Hlusicka, Jiri, Kotikova, Katerina, Navratil, Tomas, Komarc, Martin, Vaneckova, Manuela, Seidl, Zdenek, Diblik, Pavel, Bydzovsky, Jan, Heissigerova, Jarmila, Zogala, David, Hubacek, Jaroslav A., Miovsky, Michal, Sejvl, Jaroslav, Vojtova, Lucie, and Pelclova, Daniela

Subjects
FORMALDEHYDE, HOSPITAL mortality, ADULT respiratory distress syndrome, CANCER-related mortality, BRAIN damage, METHANOL
Abstract

Context: The influence of co-morbid conditions on the outcome of acute methanol poisoning in mass poisoning outbreaks is not known. Objective: The objective of this is to study the impact of burden of co-morbidities, complications, and methanol-induced brain lesions on hospital, follow-up, and total mortality. Methods: All patients hospitalized with methanol poisoning during a mass poisoning outbreak were followed in a prospective cohort study until death or final follow-up after 6 years. The age-adjusted Charlson co-morbidity index (ACCI) score was calculated for each patient. A multivariate Cox regression model was used to calculate the adjusted hazards ratio (HR) for death. The survival was modeled using the Kaplan–Meier method. Results: Of 108 patients (mean age with SD 50.9 ± 2.6 years), 24 (54.4 ± 5.9 years) died during hospitalization (mean survival with SD 8 ± 4 days) and 84 (49.9 ± 3.0 years; p =.159) were discharged, including 27 with methanol-induced brain lesions. Of the discharged patients, 15 (56.3 ± 6.8 years) died during the follow-up (mean survival 37 ± 11 months) and 69 (48.5 ± 3.3 years; p =.044) survived. The hospital mortality was 22%, the follow-up mortality was 18%; the total mortality was 36%. Cardiac/respiratory arrest, acute respiratory failure, multiorgan failure syndrome, and arterial hypotension increased the HR for hospital and total (but not follow-up) mortality after adjustment for age, sex, and arterial pH (all p <.05). All patients who died in the hospital had at least one complication. A higher ACCI score was associated with greater total mortality (HR 1.22; 1.00–1.48 95% CI; p =.046). Of those who died, 35 (90%) had a moderate-to-high ACCI. The Kaplan–Meier curve demonstrated that patients with a high ACCI had greater follow-up mortality compared to ones with low (p =.027) or moderate (p =.020) scores. For the patients who died during follow-up, cancers of different localizations were responsible for 7/15 (47%) of the deaths. Conclusions: The character and number of complications affected hospital but not follow-up mortality, while the burden of co-morbidities affected follow-up mortality. Methanol-induced brain lesions did not affect follow-up mortality. Relatively high cancer mortality rate may be associated with acute exposure to metabolic formaldehyde produced by methanol oxidation. [ABSTRACT FROM AUTHOR]

Published
2020
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30. Neuroinflammation markers and methyl alcohol induced toxic brain damage

Author

Zakharov, Sergey, primary, Hlusicka, Jiri, additional, Nurieva, Olga, additional, Kotikova, Katerina, additional, Lischkova, Lucie, additional, Kacer, Petr, additional, Kacerova, Tereza, additional, Urban, Pavel, additional, Vaneckova, Manuela, additional, Seidl, Zdenek, additional, Diblik, Pavel, additional, Kuthan, Pavel, additional, Heissigerova, Jarmila, additional, Lesovsky, Jiri, additional, Rulisek, Jan, additional, Vojtova, Lucie, additional, Hubacek, Jaroslav A., additional, and Navratil, Tomas, additional

Published
2018
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31. Clinical and genetic determinants of chronic visual pathway changes after methanol - induced optic neuropathy: four-year follow-up study

Author

Nurieva, Olga, primary, Hubacek, Jaroslav A, additional, Urban, Pavel, additional, Hlusicka, Jiri, additional, Diblik, Pavel, additional, Kuthan, Pavel, additional, Sklenka, Petr, additional, Meliska, Martin, additional, Bydzovsky, Jan, additional, Heissigerova, Jarmila, additional, Kotikova, Katerina, additional, Navratil, Tomas, additional, Komarc, Martin, additional, Seidl, Zdenek, additional, Vaneckova, Manuela, additional, Vojtova, Lucie, additional, and Zakharov, Sergey, additional

Published
2018
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32. Reply

Author

Zakharov, Sergey, primary, Nurieva, Olga, additional, Diblik, Pavel, additional, Kuthan, Pavel, additional, Sklenka, Petr, additional, Meliska, Martin, additional, Bydzovsky, Jan, additional, Heissigerova, Jarmila, additional, Urban, Pavel, additional, Kotikova, Katerina, additional, Navratil, Tomas, additional, Komarc, Martin, additional, Seidl, Zdenek, additional, Vaneckova, Manuela, additional, and Pelclova, Daniela, additional

Published
2018
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34. Great reduction of correlation between global and regional brain volume and spinal cord volume in multiple sclerosis patients with severe disability (P3.349)

Author

Vaneckova, Manuela, primary, Andelova, Michaela, additional, Krasensky, Jan, additional, Sobisek, Lukas, additional, Seidl, Zdenek, additional, Kusova, Eliska, additional, Uher, Tomas, additional, Havrdova, Eva, additional, Benova, Barbora, additional, Marechal, Benedicte, additional, Kober, Tobias, additional, and Horakova, Dana, additional

Published
2018
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38. Pathological cut-offs of global and regional brain volume loss in multiple sclerosis

Author

Uher, Tomas, primary, Vaneckova, Manuela, additional, Krasensky, Jan, additional, Sobisek, Lukas, additional, Tyblova, Michaela, additional, Volna, Jana, additional, Seidl, Zdenek, additional, Bergsland, Niels, additional, Dwyer, Michael G, additional, Zivadinov, Robert, additional, De Stefano, Nicola, additional, Sormani, Maria Pia, additional, Havrdova, Eva Kubala, additional, and Horakova, Dana, additional

Published
2017
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39. Association of Quantitative MRI to Radiological Reporting for the Evaluation of Lesion Burden Status in Multiple Sclerosis: A Multi-Center Study (P4.358)

Author

Ribbens, Annemie, primary, Billiet, Thibo, additional, Beadnall, Heidi, additional, Vaneckova, Manuela, additional, Weinstock-Guttman, Bianca, additional, Ly, Linda, additional, Wang, Chenyu, additional, Ramasamy, Deepa, additional, Houbrechts, Ruben, additional, Bergsland, Niels, additional, Seidl, Zdenek, additional, Uher, Tomas, additional, Van Hecke, Wim, additional, Horakova, Dana, additional, Zivadinov, Robert, additional, and Barnett, Michael, additional

Published
2017
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41. Leukotriene-mediated neuroinflammation, toxic brain damage, and neurodegeneration in acute methanol poisoning

Author

Zakharov, Sergey, primary, Kotikova, Katerina, additional, Nurieva, Olga, additional, Hlusicka, Jiri, additional, Kacer, Petr, additional, Urban, Pavel, additional, Vaneckova, Manuela, additional, Seidl, Zdenek, additional, Diblik, Pavel, additional, Kuthan, Pavel, additional, Navratil, Tomas, additional, and Pelclova, Daniela, additional

Published
2017
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42. Clinical and genetic determinants of chronic visual pathway changes after methanol - induced optic neuropathy: four-year follow-up study.

Author

Nurieva, Olga, Hlusicka, Jiri, Kotikova, Katerina, Zakharov, Sergey, Urban, Pavel, Hubacek, Jaroslav A, Diblik, Pavel, Kuthan, Pavel, Sklenka, Petr, Meliska, Martin, Bydzovsky, Jan, Heissigerova, Jarmila, Navratil, Tomas, Komarc, Martin, Seidl, Zdenek, Vaneckova, Manuela, and Vojtova, Lucie

Subjects
OPTIC nerve diseases, METHANOL, POISONING, VISUAL pathways, NEURODEGENERATION, VISUAL evoked potentials, APOLIPOPROTEIN E
Abstract

Context: Methanol poisoning induces acute optic neuropathy with possible long-term visual damage. Objective: To study the dynamics and key determinants of visual pathway functional changes during 4 years after acute methanol poisoning. Methods: A total of 42 patients with confirmed methanol poisoning (mean age 45.7 ± 4.4 years) were examined 4.9 ± 0.6, 25.0 ± 0.6, and 49.9 ± 0.5 months after discharge. The following tests were performed: visual evoked potential (VEP), retinal nerve fiber layer (RNFL) measurement, brain magnetic resonance imaging (MRI), complete ocular examination, biochemical tests, and apolipoprotein E (ApoE) genotyping. Results: Abnormal VEP P1 latency was registered in 18/42 right eyes (OD) and 21/42 left eyes (OS), abnormal N1P1 amplitude in 10/42 OD and OS. Mean P1 latency shortening during the follow-up was 15.0 ± 2.0 ms for 36/42 (86%) OD and 14.9 ± 2.4 ms for 35/42 (83%) OS, with maximum shortening up to 35.0 ms. No significant change of mean N1P1 amplitude was registered during follow-up. A further decrease in N1P1 amplitude ≥1.0 mcV in at least one eye was observed in 17 of 36 patients (47%) with measurable amplitude (mean decrease −1.11 ± 0.83 (OD)/−2.37 ± 0.66 (OS) mcV versus −0.06 ± 0.56 (OD)/−0.83 ± 0.64 (OS) mcV in the study population; both p <.001). ApoE4 allele carriers had lower global and temporal RNFL thickness and longer initial P1 latency compared to the non-carriers (all p <.05). The odds ratio for abnormal visual function was 8.92 (3.00–36.50; 95%CI) for ApoE4 allele carriers (p <.001). The presence of ApoE4 allele was further associated with brain necrotic lesions (r = 0.384; p =.013) and brain hemorrhages (r = 0.395; p =.011). Conclusions: Improvement of optic nerve conductivity occurred in more than 80% of patients, but evoked potential amplitude tended to decrease during the 4 years of observation. ApoE4 allele carriers demonstrated lower RNFL thickness, longer P1 latency, and more frequent methanol-induced brain damage compared to non-carriers. [ABSTRACT FROM AUTHOR]

Published
2019
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43. Pathological cut-offs of global and regional brain volume loss in multiple sclerosis.

Author

Uher, Tomas, Vaneckova, Manuela, Krasensky, Jan, Sobisek, Lukas, Tyblova, Michaela, Volna, Jana, Seidl, Zdenek, Bergsland, Niels, Dwyer, Michael G., Zivadinov, Robert, De Stefano, Nicola, Sormani, Maria Pia, Havrdova, Eva Kubala, and Horakova, Dana

Subjects
MULTIPLE sclerosis, CORPUS callosum, BIOMARKERS, BRAIN, DISEASE progression
Abstract

Background: Volumetric MRI surrogate markers of disease progression are lacking. Objective: To establish cut-off values of brain volume loss able to discriminate between healthy controls and MS patients. Methods: In total, 386 patients after first demyelinating event suggestive of MS (CIS), 964 relapsing-remitting MS (RRMS) patients, 63 secondary-progressive MS (SPMS) patients and 58 healthy controls were included in this longitudinal study. A total of 11,438 MRI scans performed on the same MRI scanner with the same protocol were analysed. Annualised percentage changes of whole brain, grey matter, thalamus and corpus callosum volumes were estimated. We investigated cut-offs able to discriminate between healthy controls and MS patients. Results: At a predefined specificity of 90%, the annualised percentage change cut-off of corpus callosum volume (−0.57%) was able to distinguish between healthy controls and patients with the highest sensitivity (51% in CIS, 48% in RRMS and 42% in SPMS patients). Lower sensitivities (22%−49%) were found for cut-offs of whole brain, grey matter and thalamic volume loss. Among CIS and RRMS patients, cut-offs were associated with greater accumulation of disability. Conclusion: We identified cut-offs of annualised global and regional brain volume loss rates able to discriminate between healthy controls and MS patients. [ABSTRACT FROM AUTHOR]

Published
2019
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44. Reliable measurements of brain atrophy in individual patients with multiple sclerosis

Author

Smeets, Dirk, primary, Ribbens, Annemie, additional, Sima, Diana M., additional, Cambron, Melissa, additional, Horakova, Dana, additional, Jain, Saurabh, additional, Maertens, Anke, additional, Van Vlierberghe, Eline, additional, Terzopoulos, Vasilis, additional, Van Binst, Anne‐Marie, additional, Vaneckova, Manuela, additional, Krasensky, Jan, additional, Uher, Tomas, additional, Seidl, Zdenek, additional, De Keyser, Jacques, additional, Nagels, Guy, additional, De Mey, Johan, additional, Havrdova, Eva, additional, and Van Hecke, Wim, additional

Published
2016
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48. Absence of HDL Decrease after Interferon Beta-1a Initiation Is Associated with Greater Brain Volume Loss and Lesion Burden in Multiple Sclerosis Patiens over 4 Years (P3.019)

Author

Uher, Tomas, primary, Horakova, Dana, additional, Fellows, Kelly, additional, Vaneckova, Manuela, additional, Sobisek, Lukas, additional, Seidl, Zdenek, additional, Tyblova, Michaela, additional, Krasensky, Jan, additional, Havrdova, Eva, additional, and Ramanathan, Murali, additional

Published
2016
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