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1. ALPINE FARM SCALE INVESTIGATIONS OF THE RELATIONSHIPS BETWEEN PRODUCTIVE SYSTEM AND QUALITY OF DAIRY PRODUCTS

Author

Segato S., Stefania Balzan, Carla Azzurra Elia, Ariadne Granata, Laura Lignitto, S. Tenti, I. Andrighetto, and E. Novelli

Subjects
dairy cow, alpine farm, sustainability, grazing, milk quality, Agriculture (General), S1-972, Plant culture, SB1-1110
Abstract

Alpine dairy farming is shifted from an extensive activity based on pasture and low genetic merit cow to an intensive system with specialized breeds and increasing level of concentrate as a supplement in the diet. As a main consequence, a lower echo-compatibility could determine adverse externalities on environment and quality of dairy products. Considering 18 dairy farming located in the mountain area of Veneto Region (Italy), the Environmental Summarizing Indicator (ESI) was estimated by using agronomic and dairying variables. Results indicated that variability of ESI was manly due to productive performance of dairy cows probably because there was a lack of information in the assessment of pasture characteristics. However, higher level of ESI were closely related to the increase of N-phile species and/or less attractive vegetation for grazing cows, even if the indicator seems to explain only a limited part of the variability of the phenomenon. The increase of ESI values seemed to lead to a loss of nutritive value of milk because of the incidence of health favourable fatty acids was reduced.

Published
2007

2. The interaction of patients’ physical status and time to endoscopy on mortality risk in patients with upper gastrointestinal bleeding: A national prospective cohort study

Author

Amitrano, L, Anderloni, A, Andriulli, A, Annese, V, Baldassarre, G, Bargiggia, S, Balzano, A, Bazzoli, F, Bennato, R, Bianco, M A, Bizzotto, A, Boarino, V, Bonanomi, AG, Borgheresi, P, Bresci, G, Buffoli, F, Buscarini, E, Castrignanò, G, Cavallaro, LG, Cesaro, P, Chirico, A, Cipolletta, F, Cipolletta, L, Conigliaro, R, Conte, D, Costamagna, G, Covello, F, D'Amico, G, De Fanis, C, De Filippo, FR, de Franchis, R, Dell‘Era, A, De Nigris, F, De Matthaeis, M, Di Giorgio, P, Di Giulio, E, Esposito, P, Ferraris, L, Filippino, A, Franceschi, M, Furio, L, Germana’, B, Grassia, R, Imperiali, G, Lamanda, R, Lauri, A, Londoni, C, Mangiafico, S, Manno, M, Marmo, C, Merighi, A, Meroni, R, Metrangolo, S, Montalbano, L M, Napolitano, G, Nucci, A, Orsini, L, Parente, F, Parravicini, M, Paterlini, A, Pumpo, R, Purita, L, Repici, A, Riccioni, ME, Russo, A, Segato, S, Sorrentino, I, Spinzi, G, Spotti, D, Tortora, A, Tomba, C, Triossi, O, Zagari, RM, Zambelli, A, Bucci, Cristina, Marmo, Clelia, Soncini, Marco, Riccioni, Maria Elena, Laursen, Stig B., Gralnek, Ian M., and Marmo, Riccardo

Published
2024
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5. The "Hub and Spoke" model has no effect on mortality in acute upper gastrointestinal bleeding: A prospective multicenter cohort study

Author

Amitrano, L, Anderloni, A, Andriulli, A, Annese, V, Baldassarre, G, Bargiggia, S, Bazzoli, F, Bennato, R, Bianco, MA, Bizzotto, A, Boarino, V, Bonanomi, AG, Borgheresi, P, Bresci, G, Buffoli, F, Buscarini, E, Castrignanò, G, Cavallaro, LG, Cesaro, P, Chirico, A, Cipolletta, F, Cipolletta, L, Conigliaro, R, Conte, D, Costamagna, G, Covello, F, D'Amico, G, De-Fanis, C, De-Filippo, FR, de-Franchis, R, Dell‘Era, A, De Nigris, F, De-Matthaeis, M, Di-Giorgio, P, Di-Giulio, E, Esposito, P, Ferraris, L, Filippino, A, Franceschi, M, Furio, L, Germana', B, Grassia, R, Imperiali, G, Lamanda, R, Lauri, A, Londoni, C, Mangiafico, S, Manno, M, Marmo, C, Merighi, A, Meroni, R., Metrangolo, S, Montalbano, LM, Napolitano, G, Nucci, A, Orsini, L, Parente, F, Parravicini, M, Paterlini, A, Pumpo, R, Purita, L, Repici, A, Riccioni, ME, Russo, A, Segato, S, Sorrentino, I, Spinzi, G, Spotti, D, Tortora, A, Tomba, C, Triossi, O, Zagari, RM, Zambelli, A, Marmo, Riccardo, Soncini, Marco, Bucci, Cristina, and Zullo, Angelo

Published
2021
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7. Continuous clinical remission with biologics in ulcerative colitis: the 'AURORA' comparison study

Author

Cassinotti, A, Mezzina, N, De Silvestri, A, Di Paolo, D, Lenti, M, Bezzio, C, Stradella, D, Mauri, M, Zadro, V, Ricci, C, Casini, V, Radice, E, Massari, A, Maconi, G, Saibeni, S, Caprioli, F, Tari, R, Fichera, M, Cortelezzi, C, Parravicini, M, Tinelli, C, Testoni, P, Pace, F, Segato, S, Invernizzi, P, Occhipinti, P, Manes, G, Di Sabatino, A, Pastorelli, L, Vecchi, M, Ardizzone, S, Cassinotti A., Mezzina N., De Silvestri A., Di Paolo D., Lenti M. V., Bezzio C., Stradella D., Mauri M., Zadro V., Ricci C., Casini V., Radice E., Massari A., Maconi G., Saibeni S., Caprioli F., Tari R., Fichera M., Cortelezzi C. C., Parravicini M., Tinelli C., Testoni P. A., Pace F., Segato S., Invernizzi P., Occhipinti P., Manes G., Di Sabatino A., Pastorelli L., Vecchi M., Ardizzone S., Cassinotti, A, Mezzina, N, De Silvestri, A, Di Paolo, D, Lenti, M, Bezzio, C, Stradella, D, Mauri, M, Zadro, V, Ricci, C, Casini, V, Radice, E, Massari, A, Maconi, G, Saibeni, S, Caprioli, F, Tari, R, Fichera, M, Cortelezzi, C, Parravicini, M, Tinelli, C, Testoni, P, Pace, F, Segato, S, Invernizzi, P, Occhipinti, P, Manes, G, Di Sabatino, A, Pastorelli, L, Vecchi, M, Ardizzone, S, Cassinotti A., Mezzina N., De Silvestri A., Di Paolo D., Lenti M. V., Bezzio C., Stradella D., Mauri M., Zadro V., Ricci C., Casini V., Radice E., Massari A., Maconi G., Saibeni S., Caprioli F., Tari R., Fichera M., Cortelezzi C. C., Parravicini M., Tinelli C., Testoni P. A., Pace F., Segato S., Invernizzi P., Occhipinti P., Manes G., Di Sabatino A., Pastorelli L., Vecchi M., and Ardizzone S.

Abstract

Objectives Comparative trials among biological drugs for the treatment of ulcerative colitis (UC) provided conflicting results. After patent expire of infliximab originator, adalimumab, infliximab biosimilar, golimumab and vedolizumab have been approved in Italy. We compared the efficacy of these four biologics in UC according to the concept of continuous clinical remission (CCR). Methods In a retrospective, multicentre study, all UC patients treated with adalimumab, infliximab biosimilar, golimumab or vedolizumab between 2014 and 2019 were included. All drugs were compared to each other according to the 1-year CCR rate, defined as Mayo partial score ≤2, with bleeding subscore = 0, without any relapse or optimization with dose escalation, topical treatments or steroid use after first clinical remission. Results Four-hundred sixteen patients (adalimumab = 90, infliximab biosimilar = 105, golimumab = 79, vedolizumab = 142) were included. CCR was achieved in similar percentages among the groups (33%, 37%, 28%, 37%, respectively). All drugs were equivalent in biologic-naive patients, while vedolizumab was better than a second anti-TNF in prior anti-TNF agent failures. No differences were found according to type of adverse events or severe adverse events. Conclusions Based on a strict definition of clinical remission, all biologics appear equally effective at 1 year. Changing to vedolizumab is more effective than switching to another anti-TNF in TNF failures.

Published
2022

9. Factors influencing the presence of potentially explosive gases during colonoscopy: Results of the SATISFACTION study

Author

Carnovali, M., Spada, Cristiano, Uebel, P., Bocus, P., Cannizzaro, Rino, Cavallaro, Fabio, Cesana, Bruno Mario, Cesaro, Paola, Costamagna, Guido, Dipaolo, D., Ferrari, A. P., Hinkel, C., Kashin, S., Massella, A., Melnikova, E., Orsatti, A., Ponchon, T., Prada, A., Radaelli, F., Sferrazza, Silvia, Soru, P., Testoni, P. A., Tontini, G. E., Vecchi, M., Fiori, G., Adyshirin, Z. S., Amato, Arianna, Anesi, A., Arpurt, J. P., Attardo, S., Balzarini, M., Bellon, S., Benini, M., Blanc, P., Bonato, G., Bordin, D., Bravi, I., Bulanova, N., Bunkova, E., Cadoni, S., Carparelli, S., Chashkova, E. Y., Ciprandi, Guido, Ciuffini, Cristina, Codazzi, M., Elli, L., Fedorishina, O., Hartmann, D., Jakobs, R., Janke, D., Kamalova, O., Karpova, I., Khitaryan, A., Lombardo, V., Lovera, Mauro, Maiero, S., Manes, G., Martino, G., Merkulova, E., Mura, D., Mutignani, Massimiliano, Occhipinti, P., Pescarolo, M., Petruzziello, Lucio, Pioche, M., Pisani, Anna, Poltorykhina, E., Pretti, C., Puzzono, M., Realdon, S., Reiche, P., Roberto, P., Roman, K., Rondonotti, E., Schettino, M., Segato, S., Shishin, K., Spina, L., Stefania, M., Trovato, C., Valats, J. C., Vena, N., Veselov, V., Viale, E., Vollmar, J., Zavyalov, D., Zimmermann, Thomas Alexander, Spada C. (ORCID:0000-0002-5692-0960), Cannizzaro R., Cavallaro F., Cesana B. M., Cesaro P., Costamagna G. (ORCID:0000-0002-8100-2731), Sferrazza S., Amato A., Ciprandi G., Ciuffini C., Lovera M., Mutignani M. (ORCID:0000-0002-1272-4888), Petruzziello L., Pisani A., Zimmermann T., Carnovali, M., Spada, Cristiano, Uebel, P., Bocus, P., Cannizzaro, Rino, Cavallaro, Fabio, Cesana, Bruno Mario, Cesaro, Paola, Costamagna, Guido, Dipaolo, D., Ferrari, A. P., Hinkel, C., Kashin, S., Massella, A., Melnikova, E., Orsatti, A., Ponchon, T., Prada, A., Radaelli, F., Sferrazza, Silvia, Soru, P., Testoni, P. A., Tontini, G. E., Vecchi, M., Fiori, G., Adyshirin, Z. S., Amato, Arianna, Anesi, A., Arpurt, J. P., Attardo, S., Balzarini, M., Bellon, S., Benini, M., Blanc, P., Bonato, G., Bordin, D., Bravi, I., Bulanova, N., Bunkova, E., Cadoni, S., Carparelli, S., Chashkova, E. Y., Ciprandi, Guido, Ciuffini, Cristina, Codazzi, M., Elli, L., Fedorishina, O., Hartmann, D., Jakobs, R., Janke, D., Kamalova, O., Karpova, I., Khitaryan, A., Lombardo, V., Lovera, Mauro, Maiero, S., Manes, G., Martino, G., Merkulova, E., Mura, D., Mutignani, Massimiliano, Occhipinti, P., Pescarolo, M., Petruzziello, Lucio, Pioche, M., Pisani, Anna, Poltorykhina, E., Pretti, C., Puzzono, M., Realdon, S., Reiche, P., Roberto, P., Roman, K., Rondonotti, E., Schettino, M., Segato, S., Shishin, K., Spina, L., Stefania, M., Trovato, C., Valats, J. C., Vena, N., Veselov, V., Viale, E., Vollmar, J., Zavyalov, D., Zimmermann, Thomas Alexander, Spada C. (ORCID:0000-0002-5692-0960), Cannizzaro R., Cavallaro F., Cesana B. M., Cesaro P., Costamagna G. (ORCID:0000-0002-8100-2731), Sferrazza S., Amato A., Ciprandi G., Ciuffini C., Lovera M., Mutignani M. (ORCID:0000-0002-1272-4888), Petruzziello L., Pisani A., and Zimmermann T.

Abstract

This study tested the hypothesis that bowel preparation with mannitol should not affect the colonic concentration of H2 and CH4. Therefore, the SATISFACTION study, an international, multicenter, randomized, parallel-group phase II–III study investigated this issue. The phase II dose-finding part of the study evaluated H2, CH4, and O2 concentrations in 179 patients randomized to treatment with 50 g, 100 g, or 150 g mannitol. Phase III of the study compared the presence of intestinal gases in 680 patients randomized (1:1) to receive mannitol 100 g in single dose or a standard split-dose 2 L polyethylene glycol (PEG)-Asc preparation (2 L PEG-Asc). Phase II results showed that mannitol did not influence the concentration of intestinal gases. During phase III, no patient in either group had H2 or CH4 concentrations above the critical thresholds. In patients with H2 and/or CH4 levels above detectable concentrations, the mean values were below the risk thresholds by at least one order of magnitude. The results also highlighted the effectiveness of standard washing and insufflation maneuvers in removing residual intestinal gases. In conclusion, bowel cleansing with mannitol was safe as the concentrations of H2 and CH4 were the same as those found in patients prepared with 2 L PEG-Asc. In both groups, the concentrations of gases were influenced more by the degree of cleansing achieved and the insufflation and washing maneuvers performed than by the preparation used for bowel cleansing. The trial protocol was registered with ClinicalTrials.gov (https://clinicaltrials.gov/ct2/show/NCT04759885) and with EudraCT (eudract_number: 2019-002856-18).

Published
2023

10. The interplay between thyroid and liver: implications for clinical practice

Author

Piantanida, E., Ippolito, S., Gallo, D., Masiello, E., Premoli, P., Cusini, C., Rosetti, S., Sabatino, J., Segato, S., Trimarchi, F., Bartalena, L., and Tanda, M. L.

Abstract

A complex relationship exists between thyroid and liver in health and disease. Liver plays an essential physiological role in thyroid hormone activation and inactivation, transport, and metabolism. Conversely, thyroid hormones affect activities of hepatocytes and hepatic metabolism. Serum liver enzyme abnormalities observed in hypothyroidism may be related to impaired lipid metabolism, hepatic steatosis or hypothyroidism-induced myopathy. Severe hypothyroidism may have biochemical and clinical features, such as hyperammonemia and ascites, mimicking those of liver failure. Liver function tests are frequently abnormal also in hyperthyroidism, due to oxidative stress, cholestasis, or enhanced osteoblastic activity. Antithyroid drug-associated hepatotoxicity is a rare event, likely related mainly to an idiosyncratic mechanism, ranging from a mild hepatocellular damage to liver failure. Propylthiouracil-induced liver damage is usually more severe than that caused by methimazole. On the other hand, thyroid abnormalities can be found in liver diseases, such as chronic hepatitis C, liver cirrhosis, hepatocellular carcinoma, and cholangiocarcinoma. In particular, autoimmune thyroid diseases are frequently found in patients with hepatitis C virus infection. These patients, especially if thyroid autoimmunity preexists, are at risk of hypothyroidism or, less frequently, thyrotoxicosis, during and after treatment with interpheron-alpha alone or in combination with ribavirin, commonly used before the introduction of new antiviral drugs. The present review summarizes both liver abnormalities related to thyroid disorders and their treatment, and thyroid abnormalities related to liver diseases and their treatment.

Published
2024
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14. T.04.5 ARE THE ESGE COMPETENCE STANDARDS FOR OPTICAL DIAGNOSIS OF DIMINUTIVE COLORECTAL LESIONS ACHIEVABLE IN ULCERATIVE COLITIS? THE ROLE OF DIAGNOSTIC CRITERIA

Author

Cassinotti, A., primary, Corona, A., additional, Ardizzone, S., additional, Segato, S., additional, Balzarini, M., additional, Nebuloni, M., additional, Sessa, F., additional, Ferraris, M., additional, Maconi, G., additional, Parravicini, M., additional, and Cortelezzi, C.C., additional

Published
2022
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15. T.06.8 COMPARATIVE OBJECTIVE EFFECTIVENESS OF VEDOLIZUMAB AND USTEKINUMAB IN A REAL-LIFE COHORT OF ACTIVE CROHN’S DISEASE PATIENTS FAILURE TO TNF INHIBITORS

Author

Onali, S., primary, Pugliese, D., additional, Caprioli, F.A., additional, Orlando, A., additional, Biancone, L., additional, Nardone, O.M., additional, Imperatore, N., additional, Fiorino, G., additional, Cappello, M., additional, Viola, A., additional, Principi, M.B., additional, Bezzio, C., additional, Aratari, A., additional, Carparelli, S., additional, Mancuso, F., additional, Grossi, L., additional, Bodini, G., additional, Ribaldone, D., additional, Mocci, G., additional, Favale, A., additional, Grova, M., additional, Scucchi, L., additional, Segato, S., additional, Fries, W., additional, Castiglione, F., additional, Armuzzi, A., additional, and Fantini, M.C., additional

Published
2022
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16. OC.02.4 PREVALENCE AND PREDICTORS OF NEOPLASTIC AND NONNEOPLASTIC POLYPOID AND NON-POLYPOID LESIONS IN ULCERATIVE COLITIS IN THE ERA OF POWERED ENDOSCOPY: A SYSTEMATIC REAL-LIFE STUDY ON 1120 LESIONS

Author

Cassinotti, A., primary, Corona, A., additional, Segato, S., additional, Nebuloni, M., additional, Sessa, F., additional, Maconi, G., additional, Cortelezzi, C.C., additional, Parravicini, M., additional, Ferraris, M., additional, Balzarini, M., additional, and Ardizzone, S., additional

Published
2022
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19. P613 Comparative objective effectiveness of vedolizumab and ustekinumab in a real-life cohort of active Crohn’s disease patients failure to TNF inhibitors

Author

Onali, S, primary, Pugliese, D, additional, Caprioli, F A, additional, Orlando, A, additional, Biancone, L, additional, Nardone, O M, additional, Imperatore, N, additional, Fiorino, G, additional, Cappello, M, additional, Viola, A, additional, Principi, M B, additional, Bezzio, C, additional, Aratari, A, additional, Carparelli, S, additional, Mazzuoli, S, additional, Manguso, F, additional, Grossi, L, additional, Bodini, G, additional, Ribaldone, D, additional, Mocci, G, additional, Minerba, L, additional, Favale, A, additional, Grova, M, additional, Scucchi, L, additional, Segato, S, additional, Fries, W, additional, Castiglione, F, additional, Armuzzi, A, additional, and Fantini, M C, additional

Published
2022
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20. Derivation and validation of Re.Co.De death score risk in patients with acute nonvariceal upper GI bleeding

Author

Riccardo Marmo, Marco Soncini, Cristina Bucci, Vincenzo Occhipinti, Lucienne Pellegrini, Angelo Zullo, Amitrano L, Andriulli A, Annese V, Baldassarre G, Bargiggia S, Balzano A, Bazzoli F, Bennato R, Bianco M A, Bizzotto A, Boarino V, Bonanomi AG, Borgheresi P, Bresci G, Buffoli F, Buscarini E, Castrignanò G, Cavallaro LG, Cesaro P, Chirico A, Cipolletta F, Cipolletta L, Conigliaro R, Conte D, Costamagna G, D’ Amico G, De Fanis C, De Filippo FR, de Franchis R, Dell‘ Era A, De Nigris F, De Matthaeis M, Di Giorgio P, Di Giulio E, Esposito P, Ferraris L, Filippino A, Franceschi M, Furio L, Germana B, Grassia R, Imperiali G, Lamanda R, Lauri A, Londoni C, Mangiafico S, Manno M, Marmo C, Meroni R, Metrangolo S, Montalbano L. M, Napolitano G, Nucci A, Orsini L, Parente F, Parravicini M, Paterlini A, Pumpo R, Purita L, Repici A, Riccioni ME, Russo A, Segato S, Sorrentino I, Spinzi G, Spotti D, Tortora A, Triossi O, Zagari RM, and Zambelli A

Subjects
Cohort Studies, Area Under Curve, Acute Disease, Gastroenterology, Humans, Radiology, Nuclear Medicine and imaging, Gastrointestinal Hemorrhage, Prognosis, Risk Assessment, Severity of Illness Index
Abstract

Scores in upper GI bleeding (UGIB) are used to stratify death risk and need for hospitalization at admission, but a tool that incorporates dynamic changes during the hospital stay is lacking. We aimed to develop a death risk score that considers changes in clinical status during hospitalization and compare its performance with existing ones.A multicenter cohort study enrolling patients with UGIB in 50 Italian hospitals from January 2014 to December 2015 was conducted. Data were collected and used to develop a risk score using logistic regression analyses. Performance curves (area under the receiver-operating characteristic [AUROC] curves), sensitivities, specificities, positive and negative predictive values, and outcomes classified as low, intermediate, and high death risk were calculated. The score's performance was externally validated and then compared with other scores.We included 1852 patients with nonvariceal UGIB in the development cohort and 912 in the validation cohorts. The new score, which we named the Re.Co.De (rebleeding-comorbidities-deteriorating) score, included 10 variables depicting the changes in clinical conditions while in the hospital. The mortality AUROC curves were .93 (95% confidence interval, .91-.96) in the derivation cohort and .94 (95% confidence interval, .91-.98) in validation cohort. In a comparison of AUROC curves with other scores, the new score showed a significant performance compared with pre- and postendoscopy scores. Patients with low and high scores had 30-day mortality rates of .001% and 48.2%, respectively.The Re.Co.De score has a higher performance for predicting mortality in patients with UGIB compared with other scores, correctly identifying patients at low and high death risk while in the hospital through a dynamic re-evaluation of clinical status.

Published
2021

21. The "Hub and Spoke" model has no effect on mortality in acute upper gastrointestinal bleeding: A prospective multicenter cohort study

Author

Marmo, Riccardo, primary, Soncini, Marco, additional, Bucci, Cristina, additional, Zullo, Angelo, additional, Amitrano, L, additional, Anderloni, A, additional, Andriulli, A, additional, Annese, V, additional, Baldassarre, G, additional, Bargiggia, S, additional, Bazzoli, F, additional, Bennato, R, additional, Bianco, MA, additional, Bizzotto, A, additional, Boarino, V, additional, Bonanomi, AG, additional, Borgheresi, P, additional, Bresci, G, additional, Buffoli, F, additional, Buscarini, E, additional, Castrignanò, G, additional, Cavallaro, LG, additional, Cesaro, P, additional, Chirico, A, additional, Cipolletta, F, additional, Cipolletta, L, additional, Conigliaro, R, additional, Conte, D, additional, Costamagna, G, additional, Covello, F, additional, D'Amico, G, additional, De-Fanis, C, additional, De-Filippo, FR, additional, de-Franchis, R, additional, Dell‘Era, A, additional, De Nigris, F, additional, De-Matthaeis, M, additional, Di-Giorgio, P, additional, Di-Giulio, E, additional, Esposito, P, additional, Ferraris, L, additional, Filippino, A, additional, Franceschi, M, additional, Furio, L, additional, Germana', B, additional, Grassia, R, additional, Imperiali, G, additional, Lamanda, R, additional, Lauri, A, additional, Londoni, C, additional, Mangiafico, S, additional, Manno, M, additional, Marmo, C, additional, Merighi, A, additional, Meroni, R., additional, Metrangolo, S, additional, Montalbano, LM, additional, Napolitano, G, additional, Nucci, A, additional, Orsini, L, additional, Parente, F, additional, Parravicini, M, additional, Paterlini, A, additional, Pumpo, R, additional, Purita, L, additional, Repici, A, additional, Riccioni, ME, additional, Russo, A, additional, Segato, S, additional, Sorrentino, I, additional, Spinzi, G, additional, Spotti, D, additional, Tortora, A, additional, Tomba, C, additional, Triossi, O, additional, Zagari, RM, additional, and Zambelli, A, additional

Published
2021
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22. AF.114 A COMPARATIVE AUDIT OF TWO SURVEILLANCE STRATEGIES FOR THE CHARACTERIZATION OF POLYPOID AND NON-POLYPOID LESIONS IN ULCERATIVE COLITIS WITH OR WITHOUT POWERED ENDOSCOPY AND MUCOSAL PATTERN CLASSIFICATIONS

Author

Cassinotti, A., primary, Ardizzone, S., additional, Cortelezzi, C.C., additional, Parravicini, M., additional, Balzarini, M., additional, Fociani, P., additional, Maconi, G., additional, Nebuloni, M., additional, Sessa, F., additional, and Segato, S., additional

Published
2021
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23. AF.115 EXPLORING THE DIAGNOSE AND LEAVE STRATEGY IN THE ENDOSCOPIC SURVEILLANCE FOR DYSPLASIA IN ULCERATIVE COLITIS WITHOUT USING MUCOSAL PATTERN CLASSIFICATIONS

Author

Cassinotti, A., primary, Cortelezzi, C.C., additional, Parravicini, M., additional, Balzarini, M., additional, Bisso, G., additional, Segato, S., additional, Bonecco, S., additional, Guerzoni, P., additional, Rota Bacchetta, L., additional, Piana, S., additional, Grassi, E., additional, Millefanti, L., additional, and Sessa, F., additional

Published
2021
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25. NIR spectroscopy application for assessment of the PDO Asiago cheese variety

Author

Lanza, I., Serva, L., Contiero, B., Mirisola, M., Tenti, S., Segato, S., and Cozzi, G.

Subjects
Asiago PDO, NIRItalia online 2021, Matthews correlation coefficient, spettroscopia NIR, varietà di formaggio, NIR spectroscopy, cheese variety, PLS-DA
Abstract

A conference abstract from NIRItalia online 2021 in English and Italian., This research was financially supported by Project SAFIL – Fondazione CARIVERONA (call 2016).

Published
2021
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27. Clinical management and patient outcomes of acute lower gastrointestinal bleeding. A multicenter, prospective, cohort study

Author

Radaelli, F., Frazzoni, L., Repici, A., Rondonotti, E., Mussetto, A., Feletti, V., Spada, Cristiano, Manes, G., Segato, S., Grassi, Elisa Maria, Musso, A., Di Giulio, E., Coluccio, C., Manno, M., De Nucci, G., Festa, V., Di Leo, A., Marini, Martina, Ferraris, L., Feliziani, M., Amato, A., Soriani, P., Del Bono, C., Paggi, S., Hassan, Cesare, Fuccio, L., Spada C. (ORCID:0000-0002-5692-0960), Grassi E. (ORCID:0000-0002-8456-3702), Marini M., Hassan C., Radaelli, F., Frazzoni, L., Repici, A., Rondonotti, E., Mussetto, A., Feletti, V., Spada, Cristiano, Manes, G., Segato, S., Grassi, Elisa Maria, Musso, A., Di Giulio, E., Coluccio, C., Manno, M., De Nucci, G., Festa, V., Di Leo, A., Marini, Martina, Ferraris, L., Feliziani, M., Amato, A., Soriani, P., Del Bono, C., Paggi, S., Hassan, Cesare, Fuccio, L., Spada C. (ORCID:0000-0002-5692-0960), Grassi E. (ORCID:0000-0002-8456-3702), Marini M., and Hassan C.

Abstract

Background & aim: Although acute lower GI bleeding (LGIB) represents a significant healthcare burden, prospective real-life data on management and outcomes are scanty. Present multicentre, prospective cohort study was aimed at evaluating mortality and associated risk factors and at describing patient management. Methods: Adult outpatients acutely admitted for or developing LGIB during hospitalization were consecutively enrolled in 15 high-volume referral centers. Demographics, comorbidities, medications, interventions and outcomes were recorded. Results: Overall 1,198 patients (1060 new admissions;138 inpatients) were included. Most patients were elderly (mean-age 74±15 years), 31% had a Charlson-Comorbidity-Index ≥3, 58% were on antithrombotic therapy. In-hospital mortality (primary outcome) was 3.4% (95%CI 2.5–4.6). At logistic regression analysis, independent predictors of mortality were increasing age, comorbidity, inpatient status, hemodynamic instability at presentation, and ICU-admission. Colonoscopy had a 78.8% diagnostic yield, with significantly higher hemostasis rate when performed within 24-hours than later (21.3% vs.10.8%, p = 0.027). Endoscopic hemostasis was associated with neither in-hospital mortality nor rebleeding. A definite or presumptive source of bleeding was disclosed in 90.4% of investigated patients. Conclusion: Mortality in LGIB patients is mainly related to age and comorbidities. Although early colonoscopy has a relevant diagnostic yield and is associated with higher therapeutic intervention rate, endoscopic hemostasis is not associated with improved clinical outcomes [ClinicalTrial.gov number: NCT 04364412].

Published
2021

28. Infection Control Practices and Outcomes of Endoscopy Units in the Lombardy Region of Italy A Survey From the Italian Society of Digestive Endoscopy During COVID-19 Spread

Author

Capurso, G., Archibugi, L., Vanella, G., Testoni, S. G. G., Petrone, M. C., Fanti, Lucrezia, Greco, Sara, Cavenati, S., Gaffuri, N., Lella, F., Pace, F., Cengia, G., Spada, Cristiano, Lovera, Mauro, Missale, G., Rosato, S., Radaelli, F., Buscarini, E., Parente, F., Pilati, S., Luigiano, C., Passoni, G. R., Salerno, R., Bargiggia, S., Penagini, R., Cantu, P., Fregoni, F., Giannetti, A., Devani, M., Manes, G., Fiori, G., Fontana, Paolo, Gambitta, P., Masci, E., Mutignani, Massimiliano, Gatti, M., Canani, M. B., Vailati, C., Dinelli, M. E., Marzo, V., Alvisi, C., Caramia, V., Di Sabatino, A., Mauro, A., De Grazia, F., Balzarini, M., Segato, S., Nella, G. A., Giannini, P., Leoni, Paola, Testoni, P. A., Mariani, A., Arcidiacono, P. G., Fanti L. (ORCID:0000-0003-2457-6373), Greco S., Spada C. (ORCID:0000-0002-5692-0960), Lovera M., Fontana P., Mutignani M. (ORCID:0000-0002-1272-4888), Leoni P., Capurso, G., Archibugi, L., Vanella, G., Testoni, S. G. G., Petrone, M. C., Fanti, Lucrezia, Greco, Sara, Cavenati, S., Gaffuri, N., Lella, F., Pace, F., Cengia, G., Spada, Cristiano, Lovera, Mauro, Missale, G., Rosato, S., Radaelli, F., Buscarini, E., Parente, F., Pilati, S., Luigiano, C., Passoni, G. R., Salerno, R., Bargiggia, S., Penagini, R., Cantu, P., Fregoni, F., Giannetti, A., Devani, M., Manes, G., Fiori, G., Fontana, Paolo, Gambitta, P., Masci, E., Mutignani, Massimiliano, Gatti, M., Canani, M. B., Vailati, C., Dinelli, M. E., Marzo, V., Alvisi, C., Caramia, V., Di Sabatino, A., Mauro, A., De Grazia, F., Balzarini, M., Segato, S., Nella, G. A., Giannini, P., Leoni, Paola, Testoni, P. A., Mariani, A., Arcidiacono, P. G., Fanti L. (ORCID:0000-0003-2457-6373), Greco S., Spada C. (ORCID:0000-0002-5692-0960), Lovera M., Fontana P., Mutignani M. (ORCID:0000-0002-1272-4888), and Leoni P.

Abstract

Goals: The present survey from the Italian Society of Digestive Endoscopy (SIED-Società Italiana di Endoscopia Digestiva) was aimed at reporting infection control practice and outcomes at Digestive Endoscopy Units in a high-incidence area. Background: Lombardy was the Italian region with the highest coronavirus disease-2019 (COVID-19) prevalence, at the end of March 2020 accounting for 20% of all worldwide deaths. Joint Gastro-Intestinal societies released recommendations for Endoscopy Units to reduce the risk of the contagion. However, there are few data from high-prevalence areas on adherence to these recommendations and on their efficacy. Methods: A survey was designed by the Lombardy section of SIED to analyze (a) changes in activity and organization, (b) adherence to recommendations, (c) rate of health care professionals' (HCP) infection during the COVID-19 outbreak. Results: In total, 35/61 invited centers (57.4%) participated; most modified activities were according to recommendations and had filtering face piece 2/filtering face piece 3 and water-repellent gowns available, but few had negative-pressure rooms or provided telephonic follow-up; 15% of HCPs called in sick and 6% had confirmed COVID-19. There was a trend (P = 0.07) toward different confirmed COVID-19 rates among endoscopists (7.9%), nurses (6.6%), intermediate-care technicians (3.4%), and administrative personnel (2.2%). There was no correlation between the rate of sick HCPs and COVID-19 incidence in the provinces and personal protective equipment availability and use, whereas an inverse correlation with hospital volume was found. Conclusions: Adherence to recommendations was rather good, though a minority were able to follow all recommendations. Confirmed COVID-19 seemed higher among endoscopists and nurses, suggesting that activities in the endoscopy rooms are at considerable viral spread risk.

Published
2021

32. Endoscopy units and the COVID-19 Outbreak: A Multi-Center Experience from Italy

Author

Repici, A, Pace, F, Gabbiadini, R, Colombo, M, Hassan, C, Dinelli, M, Maselli, R, Spadaccini, M, Mutignani, M, Gabbrielli, A, Signorelli, C, Spada, C, Leoni, P, Fabbri, C, Segato, S, Gaffuri, N, Mangiavillano, B, Radaelli, F, Salerno, R, Bargiggia, S, Maroni, L, Benedetti, A, Occhipinti, P, De Grazia, F, Ferraris, L, Cengia, G, Greco, S, Alvisi, C, Scarcelli, A, De Luca, L, Cereatti, F, Testoni, Pa, Mingotto, R, Aragona, G, Manes, G, Beretta, P, Amvrosiadis, G, Cennamo, V, Lella, F, Missale, G, Lagoussis, P, Triossi, O, Giovanardi, M, De Roberto, G, Canto, P, Buscarini, E, Anderloni, A, Carrara, S, Fugazza, A, Galtieri, Pa, Pellegatta, G, Antonelli, G, Rosch, T, and Sharma, P

Subjects
Coronavirus, Pandemic, Survery, COVID-19, Endoscopy
Published
2020

35. Endoscopy Units and the Coronavirus Disease 2019 Outbreak: A Multicenter Experience From Italy

Author

Repici, A., Pace, F., Gabbiadini, R., Colombo, M., Hassan, Cesare, Dinelli, M., Maselli, R., Spadaccini, M., Mutignani, Massimiliano, Gabbrielli, A., Signorelli, C., Spada, Cristiano, Leoni, Paola, Fabbri, Carlo, Segato, S., Gaffuri, N., Mangiavillano, B., Radaelli, F., Salerno, R., Bargiggia, S., Maroni, L., Benedetti, A., Occhipinti, P., De Grazia, F., Ferraris, L., Cengia, G., Greco, Sara, Alvisi, C., Scarcelli, A., De Luca, L., Cereatti, F., Testoni, P. A., Mingotto, R., Aragona, G., Manes, G., Beretta, P., Amvrosiadis, G., Cennamo, Vincenzo, Lella, F., Missale, G., Lagoussis, P., Triossi, O., Giovanardi, Mattia, De Roberto, G., Cantu, P., Buscarini, E., Anderloni, A., Carrara, S., Fugazza, A., Galtieri, P. A., Pellegatta, G., Antonelli, G., Rosch, T., Sharma, P., Hassan C., Mutignani M. (ORCID:0000-0002-1272-4888), Spada C. (ORCID:0000-0002-5692-0960), Leoni P., Fabbri C., Greco S., Cennamo V., Giovanardi M., Repici, A., Pace, F., Gabbiadini, R., Colombo, M., Hassan, Cesare, Dinelli, M., Maselli, R., Spadaccini, M., Mutignani, Massimiliano, Gabbrielli, A., Signorelli, C., Spada, Cristiano, Leoni, Paola, Fabbri, Carlo, Segato, S., Gaffuri, N., Mangiavillano, B., Radaelli, F., Salerno, R., Bargiggia, S., Maroni, L., Benedetti, A., Occhipinti, P., De Grazia, F., Ferraris, L., Cengia, G., Greco, Sara, Alvisi, C., Scarcelli, A., De Luca, L., Cereatti, F., Testoni, P. A., Mingotto, R., Aragona, G., Manes, G., Beretta, P., Amvrosiadis, G., Cennamo, Vincenzo, Lella, F., Missale, G., Lagoussis, P., Triossi, O., Giovanardi, Mattia, De Roberto, G., Cantu, P., Buscarini, E., Anderloni, A., Carrara, S., Fugazza, A., Galtieri, P. A., Pellegatta, G., Antonelli, G., Rosch, T., Sharma, P., Hassan C., Mutignani M. (ORCID:0000-0002-1272-4888), Spada C. (ORCID:0000-0002-5692-0960), Leoni P., Fabbri C., Greco S., Cennamo V., and Giovanardi M.

Abstract

Up to 20% of health care personnel (HCP) were found to be infected with coronavirus disease (COVID-19)1 in the outbreak in northern Italy.2 Recommendations on patient and HCP protection have been made, such as postponing procedures, triage, use of personal protective equipment (PPE), and creation of differentiated in-hospital pathways.3,4 However, several barriers against the adoption of these strategies exist, including cultural factors and shortages of medical resources; therefore, there are few reports of real-world experiences and outcomes with their adoption.5 The aim of this survey was to investigate the burden of COVID-19 on endoscopic activity in a high-risk area of COVID-19 outbreak, approaches to evaluating patients, adoption and compliance of HCP with protective measures, and initial possible viral transmission outcomes from endoscopy units within a large, community-based setting (both between patients and HCP and between HCP).

Published
2020

39. T01.01.7 THE USE OF A SPECIALIZED BLEEDING-MANAGEMENT TEAM HAD NO IMPACT ON MORTALITY FOR ACUTE UPPER GASTROINTESTINAL BLEEDING: AN ITALIAN PROSPECTIVE MULTICENTER COHORT STUDY

Author

Marmo, R., primary, Soncini, M., additional, Marmo, C., additional, Bucci, C., additional, Bennato, R., additional, Cipolletta, F., additional, Orsini, L., additional, Amitrano, L., additional, Parente, F., additional, Bargiggia, S., additional, Paterlini, A., additional, Cesaro, P., additional, Bizzotto, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, De Franchis, R., additional, Dell'Era, A., additional, Costamagna, G., additional, Riccioni, M.E., additional, Tortora, A., additional, Manno, M., additional, Mangiafico, S., additional, Conigliaro, R., additional, Bresci, G., additional, Metrangolo, S., additional, Merighi, A., additional, Boarino, V., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Imperiali, G., additional, Spotti, D., additional, Esposito, F., additional, Borgheresi, P., additional, De Filippo, F.R., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Ferraris, L., additional, Zambelli, A., additional, Londoni, C., additional, Repici, A., additional, Anderloni, A., additional, De Matthaeis, M., additional, Triossi, O., additional, Bianco, M.A., additional, Rotondano, G., additional, Lamanda, R., additional, Lauri, A., additional, De Fanis, C., additional, Di Giorgio, P., additional, Pumpo, R., additional, Furio, L., additional, Russo, A., additional, Andriulli, A., additional, Napolitano, G., additional, Montalbano, L.M., additional, Bazzoli, F., additional, Zagari, R.M., additional, Buscarini, E., additional, Cipolletta, L., additional, Conte, D., additional, Spinzi, G., additional, Di Giulio, E., additional, D'Amico, G., additional, and Balzano, A., additional

Published
2020
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40. T06.02.1 MORTALITY OF ACUTE LOWER GASTROINTESTINAL BLEEDING: A PROSPECTIVE, MULTICENTRE, COHORT STUDY

Author

Radaelli, F., primary, Frazzoni, L., additional, Repici, A., additional, Galtieri, P., additional, Mussetto, A., additional, Triossi, O., additional, Spada, C., additional, Manes, G., additional, Segato, S., additional, Grassi, E., additional, Musso, A., additional, Di Giulio, E., additional, Coluccio, C., additional, Festa, V., additional, De Nucci, G., additional, Iannone, A., additional, Ferraris, L., additional, Feliziani, M., additional, Biviano, I., additional, Soriani, P., additional, Andrealli, A., additional, Hassan, C., additional, and Fuccio, L., additional

Published
2020
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42. T06.02.2 RISK FACTORS FOR MORTALITY AMONG PATIENTS ADMITTED TO HOSPITAL FOR LOWER GASTROINTESTINAL BLEEDING: DERIVATION AND VALIDATION OF A PREDICTIVE MODEL

Author

Frazzoni, L., primary, Radaelli, F., additional, Mussetto, A., additional, Spada, C., additional, Manes, G., additional, Repici, A., additional, Del Bono, C., additional, Vassallo, M.G., additional, Segato, S., additional, Musso, A., additional, Di Giulio, E., additional, Soriani, P., additional, De Nucci, G., additional, Festa, V., additional, Di Leo, A., additional, Marini, M., additional, Ferraris, L., additional, Hassan, C., additional, Paggi, S., additional, and Fuccio, L., additional

Published
2020
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43. OC.10.1 THE USE OF PRE-ENDOSCOPIC INTRAVENOUS PROTON PUMP INHIBITORS (PPIS) HAD NO IMPACT ON CLINICAL OUTCOMES IN ACUTE UPPER GASTROINTESTINAL BLEEDING: A PROSPECTIVE MULTICENTER ITALIAN COHORT STUDY

Author

Marmo, R., primary, Soncini, M., additional, Bucci, C., additional, Bennato, R., additional, Cipolletta, F., additional, Orsini, L., additional, Amitrano, L., additional, Parente, F., additional, Bargiggia, S., additional, Paterlini, A., additional, Cesaro, P., additional, Bizzotto, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, De Franchis, R., additional, Dell'Era, A., additional, Costamagna, G., additional, Riccioni, M.E., additional, Marmo, C., additional, Tortora, A., additional, Manno, M., additional, Mangiafico, S., additional, Conigliaro, R., additional, Bresci, G., additional, Metrangolo, S., additional, Merighi, A., additional, Boarino, V., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Imperiali, G., additional, Spotti, D., additional, Esposito, F., additional, Borgheresi, P., additional, De Filippo, F.R., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Ferraris, L., additional, Zambelli, A., additional, Londoni, C., additional, Repici, A., additional, Anderloni, A., additional, De Matthaeis, M., additional, Triossi, O., additional, Bianco, M.A., additional, Rotondano, G., additional, Lamanda, R., additional, Lauri, A., additional, De Fanis, C., additional, Di Giorgio, P., additional, Pumpo, R., additional, Furio, L., additional, Russo, A., additional, Andriulli, A., additional, Napolitano, G., additional, Montalbano, L.M., additional, Bazzoli, F., additional, Zagari, R.M., additional, Buscarini, E., additional, Cipolletta, L., additional, Conte, D., additional, Spinzi, G., additional, Di Giulio, E., additional, D'Amico, G., additional, and Balzano, A., additional

Published
2020
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45. T05.02.1 ACUTE LOWER GASTROINTESTINAL BLEEDING IN ITALY (ALIBI STUDY): A MULTICENTRE PROSPECTIVE, COHORT STUDY

Author

Radaelli, F., primary, Frazzoni, L., additional, Repici, A., additional, Mussetto, A., additional, Spada, C., additional, Manes, G., additional, Segato, S., additional, Musso, A., additional, Emilio, D.G., additional, Manno, M., additional, De Nucci, G., additional, Festa, V., additional, Della Corte, C., additional, Di Leo, A., additional, Marini, M., additional, Ferraris, L., additional, Del Bono, C., additional, Hassan, C., additional, Paggi, S., additional, and Fuccio, L., additional

Published
2020
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46. OC.07.1 FACTORS INFLUENCING THE RISK OF PERSISTENT OR RECURRENT BLEEDING IN PATIENTS WITH LOWER GASTROINTESTINAL BLEEDING: RESULTS OF A PROSPECTIVE, MULTICENTRE, COHORT STUDY

Author

Frazzoni, L., primary, Radaelli, F., additional, Repici, A., additional, Mussetto, A., additional, Spada, C., additional, Del Bono, C., additional, Manes, G., additional, Segato, S., additional, Musso, A., additional, Di Giulio, E., additional, Manno, M., additional, De Nucci, G., additional, Festa, V., additional, Di Leo, A., additional, Marini, M., additional, Ferraris, L., additional, Hassan, C., additional, Amato, A., additional, Vassallo, M.G., additional, Bazzoli, F., additional, and Fuccio, L., additional

Published
2020
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47. MORTALITY OF ACUTE LOWER GASTROINTESTINAL BLEEDING: A PROSPECTIVE, MULTICENTRE, COHORT STUDY

Author

Andrealli, A, additional, Radaelli, F, additional, Frazzoni, L, additional, Repici, A, additional, Mussetto, A, additional, Spada, C, additional, Manes, G, additional, Segato, S, additional, Musso, A, additional, Giulio, ED, additional, Manno, M, additional, Nucci, GD, additional, Festa, V, additional, Leo, AD, additional, Marini, M, additional, Ferraris, L, additional, Hassan, C, additional, Fuccio, L, additional, and Paggi, S, additional

Published
2020
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48. ACUTE LOWER GASTROINTESTINAL BLEEDING IN ITALY (ALIBI STUDY): A MULTICENTRE PROSPECTIVE, COHORT STUDY

Author

Andrealli, A, additional, Radaelli, F, additional, Frazzoni, L, additional, Repici, A, additional, Mussetto, A, additional, Spada, C, additional, Manes, G, additional, Segato, S, additional, Musso, A, additional, Di Giulio, E, additional, Manno, M, additional, De Nucci, G, additional, Festa, V, additional, Di Leo, A, additional, Marini, M, additional, Ferraris, L, additional, Hassan, C, additional, Fuccio, L, additional, and Paggi, S, additional

Published
2020
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49. RISK FACTORS FOR MORTALITY AMONG PATIENTS ADMITTED TO HOSPITAL FOR LOWER GASTROINTESTINAL BLEEDING: A PREDICTIVE MODEL

Author

Bono, CD, additional, Frazzoni, L, additional, Radaelli, F, additional, Mussetto, A, additional, Spada, C, additional, Manes, G, additional, Repici, A, additional, Vassallo, MG, additional, Segato, S, additional, Musso, A, additional, Giulio, ED, additional, Soriani, P, additional, Nucci, GD, additional, Festa, V, additional, Leo, AD, additional, Marini, M, additional, Ferraris, L, additional, Hassan, C, additional, Paggi, S, additional, Fuccio, L, additional, and Andrealli, A, additional

Published
2020
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50. P566 Assessing the efficacy of biologics in ulcerative colitis: A real-life, observational retrospective multicenter study using the propensity score analysis: The ‘A.U.R.O.R.A.’ comparison study

Author

Cassinotti, A, primary, Mezzina, N, additional, Di Paolo, D, additional, Lenti, M V, additional, Bezzio, C, additional, Stradella, D, additional, Mauri, M, additional, Zadro, V, additional, Cortellezzi, C, additional, Ricci, C, additional, Casini, V, additional, Radice, E, additional, Massari, A, additional, Ardizzone, S, additional, Pastorelli, L, additional, Di Sabatino, A, additional, Manes, G, additional, Caprioli, F, additional, Vecchi, M, additional, Tari, R, additional, Occhipinti, P, additional, Fichera, M, additional, Invernizzi, P, additional, Parravicini, M, additional, Segato, S, additional, Pace, F, additional, Testoni, P A, additional, Tinelli, C, additional, and De Silvestri, A, additional

Published
2020
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