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5. Effects of topical dihydroergocristine on intraocular pressure, aqueous humor dynamics and pupil diameter in conscious rabbits. A comparative study with timolol and pilocarpine.

Author

Santafé Oroz J, Segarra Domenech J, Garrido García M, and Pablo Martínez V

Subjects
Administration, Topical, Animals, Aqueous Humor physiology, Consciousness, Dihydroergotoxine administration & dosage, Miosis chemically induced, Rabbits, Aqueous Humor drug effects, Dihydroergotoxine pharmacology, Intraocular Pressure drug effects, Pilocarpine pharmacology, Pupil drug effects, Timolol pharmacology
Abstract

This work comparatively studies the effects of dihydroergocristine, timolol and pilocarpine on intraocular pressure and pupil diameter in conscious rabbits. Intraocular pressure was measured by applanation tonometry and the pupil diameter by a photographic technique. In anesthetized rabbits, changes in tonographic facility of aqueous humor outflow and rate of aqueous humor formation were evaluated. Dihydroergocristine reduced the intraocular pressure more than timolol and much more than pilocarpine. The ocular hypotensive effect of dihydroergocristine was accomplished by a great reduction in aqueous humor formation, which surpasses the decrease in aqueous humor outflow, while timolol mainly reduced aqueous humor formation and pilocarpine increased aqueous humor outflow. Pupil diameter remained unchanged on dihydroergocristine, whereas timolol induced a slight mydriasis and pilocarpine provoked a clear myosis. Effects of dihydroergocristine might result in blockade of alpha-adrenoceptors in ciliary body, although available data about pretreatment with either metoclopramide or domperidone suggest that dopamine DA2-receptors might participate in ocular hypotensive effect of ergot derivatives.

Published
1991

6. [Before or after meals?].

Author

Segarra Domenech J and Santafé Oroz J

Subjects
Administration, Oral, Biological Availability, Humans, Intestinal Absorption, Drug Administration Schedule, Eating, Pharmaceutical Preparations metabolism
Published
1981

7. [Therapeutic update on metazoan infestations].

Author

Santafé Oroz J and Segarra Domenech J

Subjects
Animals, Cestode Infections drug therapy, Humans, Nematode Infections drug therapy, Trematode Infections drug therapy, Anthelmintics therapeutic use, Ectoparasitic Infestations drug therapy, Helminthiasis drug therapy
Published
1982

9. [Plasma cholesterol determination].

Author

Segarra Domenech J and Santafé Oroz J

Subjects
Humans, Hyperlipoproteinemias blood, Lipids blood, Lipoproteins blood, Reference Values, Cholesterol blood
Published
1981

11. [Myocardial contractility: biological bases and significance].

Author

Segarra Domenech J

Subjects
Calcium metabolism, Cardiac Output, Cardiac Volume, Electric Stimulation, Electrocardiography, Heart physiopathology, Heart Failure drug therapy, Heart Failure etiology, Hemodynamics, Microscopy, Electron, Models, Structural, Myocardium cytology, Stimulation, Chemical, Heart physiology, Muscle Contraction drug effects
Published
1968

15. [After-contractions as a cause of late diastolic "tonus increase" of the heart. Studies of diastolic extensibility of the isolated frog heart under propranolol, hexobarbital and k-strophanthin].

Author

Kissling G, Segarra-Domenech J, and Jacob R

Subjects
Animals, Cardiac Output drug effects, Cardiac Volume drug effects, Heart drug effects, Heart Failure physiopathology, Heart Function Tests, Myography, Heart physiology, Hexobarbital pharmacology, Ouabain pharmacology, Propranolol pharmacology
Published
1969

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