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18. Drug-induced psychosis and intravenous drug use in chemsex context.

Author

Curto Ramos, J., Rodríguez Laguna, A., Barrio, P., Ibarguchi, L., García, A., Azqueta, I., and Dolengevich Segal, H.

Subjects
MENTAL illness, BISEXUAL men, SEXUAL intercourse, PSYCHIATRIC diagnosis, DRUG utilization
Abstract

Introduction: Several studies have called atention to the mental health disorders associated with chemsex -the intentional use of drugs before or during sexual intercourse GBMSM (gay, bisexual and men who have sex with men) population-. Sexualized intravenous drug use is also known as slam or slamsex. There are few studies that analyze the mental health differences between intravenous drug users compared to non-intravenous drug users in chemsex context. Objectives: We aim to analyze the relationship between the practice of slamsex and the development of drug-induced psychosis. Methods: A cross-sectional descriptive analysis of a sample of users attended by the non-governmental organization Apoyo Positivo in the program "Sex, Drugs and You" between 2016-2019 was performed. Results: We included 217 participants. Drug-induced psychosis was found in 80 participants. Drug-induced psychosis was significantly higher in the intravenous drug use group compared to the non-intravenous drug use group (p<0.05). Conclusions: Previous studies have reported that MSM who practiced chemsex were more likely to experience from different mental health disorders, being psychosis one of the most frequent psychiatric diagnoses. In our study, drug-induced psychosis was higher in participants who engaged in intravenous drug use. Further studies analyzing the relationship between slamsex and drug-induced psychosis are needed. Disclosure of Interest: None Declared [ABSTRACT FROM AUTHOR]

Published
2024
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19. Anxiety disorders and intravenous drug use in chemsex context.

Author

Curto Ramos, J., Rodríguez Laguna, A., Barrio, P., Ibarguchi, L., García, A., Azqueta, I., and Dolengevich Segal, H.

Subjects
MENTAL health services, MENTAL illness, SUBSTANCE-induced disorders, BISEXUAL men, NONGOVERNMENTAL organizations, ANXIETY disorders
Abstract

Introduction: Several studies have called atention to the mental health disorders associated with chemsex -the intentional use of drugs before or during sexual intercourse GBMSM (gay, bisexual and men who have sex with men) population-. Sexualized intravenous drug use is also known as slam or slamsex. There are few studies that analyze the mental health differences between intravenous drug users compared to non-intravenous drug users in chemsex context. Objectives: We aim to describe the mental health outcomes including current and past anxiety disorders diagnosis in a sample of users with sexualized drug use (chemsex) attended by the non-governmental organization Apoyo Positivo in the program "Sex, Drugs and You" and to compare the differences of current and previous diagnosis of anxiety disorders between intravenous drug users compared to non-intravenous drug users. Methods: A cross-sectional descriptive analysis of a sample of users attended by the non-governmental organization Apoyo Positivo in the program "Sex, Drugs and You" between 2016-2019 was performed. Results: We included 217 participants. Current or past diagnosis of anxiety disorders was found in 142 participants. Anxiety disorders were significantly higher in the intravenous drug use group compared to the non-intravenous drug use group (p<0.05). Conclusions: Previous studies have reported that MSM who practiced chemsex were more likely to experience from anxiety. In our study, anxiety disorders where higher in participantes who engaged in intravenous drug use. A multidisciplinary team is necessary to address chemsex and provide care and treatment for mental health problems such as anxiety, depression, suicidal behaviour or drug-induced psychosis. Disclosure of Interest: None Declared [ABSTRACT FROM AUTHOR]

Published
2024
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20. Depressive disorders and intravenous drug use in chemsex context.

Author

Curto Ramos, J., Rodríguez Laguna, A., Barrio, P., Ibarguchi, L., García, A., Azqueta, I., and Dolengevich Segal, H.

Subjects
MENTAL health services, MENTAL illness, SUBSTANCE-induced disorders, MENTAL depression, BISEXUAL men
Abstract

Introduction: Several studies have called atention to the mental health disorders associated with chemsex -the intentional use of drugs before or during sexual intercourse GBMSM (gay, bisexual and men who have sex with men) population-. Sexualized intravenous drug use is also known as slam or slamsex. There are few studies that analyze the mental health differences between intravenous drug users compared to non-intravenous drug users in chemsex context. Objectives: We aim to describe the mental health outcomes including current and past depressive disorders diagnosis in a sample of users with sexualized drug use (chemsex) attended by the non-governmental organization Apoyo Positivo in the program "Sex, Drugs and You" and to compare the differences of current and previous diagnosis of depressive disorders between intravenous drug users compared to non-intravenous drug users. Methods: A cross-sectional descriptive analysis of a sample of users attended by the non-govenrmental organization Apoyo Positivo in the program "Sex, Drugs and You" between 2016-2019 was performed. Results: We included 217 participants. Current or past diagnosis of depression was found in 137 participants. Depressive disorders were significantly higher in the intravenous drug use group compared to the non-intravenous drug use group (p<0.05). Conclusions: Our study reports high levels of depression in chemsex users. The participants in our sample who engaged in intravenous drug use presented a higher frequency of depressive disorders than non intravenous drug use participants. Further studies analyzing the relationship between chemsex, slamsex and depresssion are needed. A multidisciplinary team is necessary to address chemsex and provide care and mental health treatment to chemsex users. Disclosure of Interest: None Declared [ABSTRACT FROM AUTHOR]

Published
2024
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21. Suicidal behaviour and intravenous drug use in chemsex context.

Author

Curto Ramos, J., Rodríguez Laguna, A., Barrio, P., Ibarguchi, L., García, A., Azqueta, I., and Dolengevich Segal, H.

Subjects
ATTEMPTED suicide, BISEXUAL men, SEXUAL intercourse, NONGOVERNMENTAL organizations, MENTAL illness
Abstract

Introduction: Several studies have called atention to the mental health disorders associated with chemsex --the intentional use of drugs before or during sexual intercourse GBMSM (gay, bisexual and men who have sex with men) population-. Sexualized intravenous drug use is also known as slam or slamsex. There are few studies that analyze the mental health differences between intravenous drug users compared to non-intravenous drug users in chemsex context. Objectives: To describe the suicidal behaviour in a sample of users with sexualized drug use (chemsex) attended by the non-governmental organization Apoyo Positivo in the program "Sex, Drugs and You" and to compare the suicidal behaviour between intravenous drug users compared to non-intravenous drug users. Methods: A cross-sectional descriptive analysis of a sample of users attended by the non-governmental organization Apoyo Positivo in the program "Sex, Drugs and You" between 2016-2019 was performed. Results: We included 217 participants. 37 had attempted suicide at least once. The percentage of chemsex users who have attempted suicide were significantly higher in the intravenous drug use group compared to the non-intravenous drug use group (p<0.05). Conclusions: Possible risk factors for suicidal behaviour among chemsex users include slamsex. Other possible risk factors previously described in other studies include adversities experienced due to one's sexual orientation and an increased risk for HIV and other STI infections. Further studies analyzing the relationship between chemsex, slamsex and suicidal behaviour are needed. Disclosure of Interest: None Declared [ABSTRACT FROM AUTHOR]

Published
2024
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23. An approach to the new psychoactive drugs phenomenon

Author

Dolengevich-Segal, H, Rodriguez-Salgado, B, Gomez-Arnau, J, and Sanchez-Mateos, D

Subjects
Spice, cathinone, education, opioids, psychoactive drugs, khat
Abstract

Background. The new psychoactive drugs (NPD) are those that represent a danger to public health and are not prohibited by conventions on international narcotics. The concept also includes new contexts and new routes of consumption as well as novel ways of distribution, notably Internet. The risks associated with NPD consumption are largely unknown to users and to health care providers. Objective. To integrate the existing evidence regarding the main NPD in terms of description, epidemiology, psychopharmacology, medical complications and psychoactive effects. Method. To review relevant and updated clinical information on NPD obtained from specialized books and indexed scientific journals (PubMed/Medline, Google Scholar, Scopus), as well as official documents edited by international organizations dedicated to the epidemiologic analysis of drug abuse and Internet websites and forums managed by psychoactive substance users. Results. Aspects of clinical and pharmacological interest are described comprehensively, together with epidemiological data and risks associated to the consumption of the most relevant NPD: synthetic cannabinoids, synthetic cathinones, NBOMe series, indoleamines, piperazines, hallucinogenic mushrooms (Psilocybe SP.), synthetic opioids, plant products (khat, kratom, Salvia divinorum, ayahuasca) and dissociative anesthetics. Discussion and conclusion. The emergence of the NPD is a phenomenon on the rise with important consequences for public health. Learning about new trends in drug consumption and its potential risks should be essential for the medical professional. New research is needed in order to understand the phenomenon of the NPD and its pharmacological, clinical and legal implications.

Published
2017

31. High incidence of defective high-shear platelet function among platelet donors

Author

Harrison, P, Segal, H, Furtado, C, Verjee, S, Sukhu, K, and Murphy, MF

Abstract

BACKGROUND: Because single-donor plateletpheresis concentrates now account for a large percentage of PLT concentrates, the PLT quality of individual donations is increasingly important. There has been little previous work on PLT function in blood donors. STUDY DESIGN AND METHODS: The aim of this study was to investigate the prevalence of defective PLT function among 100 healthy UK PLT donors on 3 consecutive donation days. Citrated blood samples were taken before plateletpheresis. High-shear PLT function testing was performed by a PLT function analyzer (PFA-100, Dade Behring), within both collagen-ADP (CADP) and collagen-epinephrine (CEPI) cartridges. RESULTS: Sixteen percent of PLT donors (mainly over the 3 donating days) had prolonged CEPI closure times (CTs) only, indicative of an aspirin-like pattern; 9 percent had a severe defect with prolonged CEPI CTs between 200 and 300 seconds, and 4 percent had maximal CEPI CTs of greater than 300 seconds. The majority of prolonged CEPI CTs appeared transient in nature. CONCLUSION: PLT dysfunction as detected by the PFA-100 is surprisingly common within a voluntary PLT donor population. The majority of CEPI defects appeared transient in nature and are indicative of surreptitious intake of cyclooxygenase inhibitors (e.g., aspirin). Identification of defective PLT function within donors would provide a simple means to eradicate defective PLTs from being clinically utilized.

Published
2016
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35. Disturbed DISC1 pathway interacts with adolescent cannabis exposure to produce impaired recognition memory restored by BDNF over-expression: a host-environment mouse model of severe mental illness

Author

Segal, H., primary, Gazit, N., additional, Barhum, Y., additional, Ben-Zur, T., additional, Taler, M., additional, Peretz, N., additional, Gil-Ad, I., additional, Weizman, A., additional, Slutzki, I., additional, Mechoulam, R., additional, Niwa, M., additional, Kamiya, A., additional, Sawa, A., additional, Offen, D., additional, and Barzilay, R., additional

Published
2016
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36. Inhaled Loxapine for The Treatment of agitation in Borderline Personality Disorder

Author

Puente, R., primary, Rabito alcon, M.F., additional, Garcìa Jorge, S., additional, Dolengevich Segal, H., additional, Benítez alonso, M., additional, Gómez- arnau Ramírez, J., additional, Garrido Beltrán, a., additional, Rodríguez Quirós, J., additional, Unzeta Conde, B., additional, Pecero García, O., additional, and Correas Lauffer, J., additional

Published
2016
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45. Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke

Author

Bellenguez, C, Bevan, S, Gschwendtner, A, Spencer, CCA, Burgess, AI, Pirinen, M, Jackson, CA, Traylor, M, Strange, A, Su, Z, Band, G, Syme, PD, Malik, R, Pera, J, Bo, N, Lemmens, R, Freeman, C, Schanz, R, James, T, Poole, D, Murphy, L, Segal, H, Cortellini, L, Cheng, YC, Woo, D, Nalls, MA, Müller-Myhsok, B, Meisinger, C, Seedorf, U, Ross-Adams, H, Boonen, S, Wloch-Kopec, D, Valant, V, Slark, J, Furie, K, Delavaran, H, Langford, C, Deloukas, P, Edkins, S, Hunt, S, Gray, E, Dronov, S, Peltonen, L, Gretarsdottir, S, Thorleifsson, G, Thorsteinsdottir, U, Stefansson, K, Boncoraglio, GB, Parati, EA, Attia, J, Holliday, E, Levi, C, Franzosi, MG, Goel, A, Helgadottir, A, Blackwell, JM, Bramon, E, Brown, MA, Casas, JP, Corvin, A, Duncanson, A, Jankowski, J, Mathew, CG, Palmer, CNA, Plomin, R, Rautanen, A, Sawcer, SJ, Trembath, RC, Viswanathan, AC, Wood, NW, Worrall, BB, Kittner, SJ, Mitchell, BD, Kissela, B, Meschia, JF, Thijs, V, Lindgren, A, MacLeod, MJ, Slowik, A, and Walters, M

Subjects
medicine.medical_specialty, Neurology, Genotype, Locus (genetics), Genome-wide association study, Disease, Biology, Bioinformatics, Polymorphism, Single Nucleotide, Histone Deacetylases, White People, Article, 03 medical and health sciences, 0302 clinical medicine, Odds Ratio, medicine, Genetics, Humans, Genetic Predisposition to Disease, 030304 developmental biology, 0303 health sciences, Atrial fibrillation, Odds ratio, medicine.disease, Confidence interval, 3. Good health, Repressor Proteins, Stroke, Chromosomes, Human, Pair 7, 030217 neurology & neurosurgery, Genome-Wide Association Study
Abstract

Genetic factors have been implicated in stroke risk, but few replicated associations have been reported. We conducted a genome-wide association study (GWAS) for ischemic stroke and its subtypes in 3,548 affected individuals and 5,972 controls, all of European ancestry. Replication of potential signals was performed in 5,859 affected individuals and 6,281 controls. We replicated previous associations for cardioembolic stroke near PITX2 and ZFHX3 and for large vessel stroke at a 9p21 locus. We identified a new association for large vessel stroke within HDAC9 (encoding histone deacetylase 9) on chromosome 7p21.1 (including further replication in an additional 735 affected individuals and 28,583 controls) (rs11984041; combined P = 1.87 × 10 -11; odds ratio (OR) = 1.42, 95% confidence interval (CI) = 1.28-1.57). All four loci exhibited evidence for heterogeneity of effect across the stroke subtypes, with some and possibly all affecting risk for only one subtype. This suggests distinct genetic architectures for different stroke subtypes. © 2012 Nature America, Inc. All rights reserved.

Published
2012
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49. 17q25 locus is associated with white matter hyperintensity volume in ischemic stroke, but not with lacunar stroke status

Author

Adib-Samii, P, Rost, N, Traylor, M, Devan, W, Biffi, A, Lanfranconi, S, Fitzpatrick, K, Bevan, S, Kanakis, A, Valant, V, Gschwendtner, A, Malik, R, Richie, A, Gamble, D, Segal, H, Parati, EA, Ciusani, E, Holliday, EG, Maguire, J, Wardlaw, J, Worrall, B, Bis, J, Wiggins, KL, Longstreth, W, Kittner, SJ, Cheng, YC, Mosley, T, Falcone, GJ, Furie, KL, Leiva-Salinas, C, Lau, BC, Khan, MS, Sharma, P, Fornage, M, Mitchell, BD, Psaty, BM, Sudlow, C, Levi, C, Boncoraglio, GB, Rothwell, PM, Meschia, J, Dichgans, M, Rosand, J, Markus, HS, Adib-Samii, P, Rost, N, Traylor, M, Devan, W, Biffi, A, Lanfranconi, S, Fitzpatrick, K, Bevan, S, Kanakis, A, Valant, V, Gschwendtner, A, Malik, R, Richie, A, Gamble, D, Segal, H, Parati, EA, Ciusani, E, Holliday, EG, Maguire, J, Wardlaw, J, Worrall, B, Bis, J, Wiggins, KL, Longstreth, W, Kittner, SJ, Cheng, YC, Mosley, T, Falcone, GJ, Furie, KL, Leiva-Salinas, C, Lau, BC, Khan, MS, Sharma, P, Fornage, M, Mitchell, BD, Psaty, BM, Sudlow, C, Levi, C, Boncoraglio, GB, Rothwell, PM, Meschia, J, Dichgans, M, Rosand, J, and Markus, HS

Abstract

Background and Purpose-Recently, a novel locus at 17q25 was associated with white matter hyperintensities (WMH) on MRI in stroke-free individuals. We aimed to replicate the association with WMH volume (WMHV) in patients with ischemic stroke. If the association acts by promoting a small vessel arteriopathy, it might be expected to also associate with lacunar stroke. Methods-We quantified WMH on MRI in the stroke-free hemisphere of 2588 ischemic stroke cases. Association between WMHV and 6 single-nucleotide polymorphisms at chromosome 17q25 was assessed by linear regression. These singlenucleotide polymorphisms were also investigated for association with lacunar stroke in 1854 cases and 51 939 stroke-free controls from METASTROKE. Meta-analyses with previous reports and a genetic risk score approach were applied to identify other novel WMHV risk variants and uncover shared genetic contributions to WMHV in community participants without stroke and ischemic stroke. Results-Single-nucleotide polymorphisms at 17q25 were associated with WMHV in ischemic stroke, the most significant being rs9894383 (P=0.0006). In contrast, there was no association between any single-nucleotide polymorphism and lacunar stroke. A genetic risk score analysis revealed further genetic components to WMHV shared between community participants without stroke and ischemic stroke. Conclusions-This study provides support for an association between the 17q25 locus and WMH. In contrast, it is not associated with lacunar stroke, suggesting that the association does not act by promoting small-vessel arteriopathy or the same arteriopathy responsible for lacunar infarction. © 2013 American Heart Association, Inc.

Published
2013

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