46 results on '"Seelen, Marc A. J."'
Search Results
2. Determination of the clinical relevance of donor epitope‐specific HLA‐antibodies in kidney transplantation
- Author
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Kardol‐Hoefnagel, Tineke, primary, Senejohnny, Danial Mohammadi, additional, Kamburova, Elena G., additional, Wisse, Bram W., additional, Reteig, Leon, additional, Gruijters, Maartje L., additional, Joosten, Irma, additional, Allebes, Wil A., additional, van der Meer, Arnold, additional, Hilbrands, Luuk B., additional, Baas, Marije C., additional, Spierings, Eric, additional, Hack, Cornelis E., additional, van Reekum, Franka E., additional, van Zuilen, Arjan D., additional, Verhaar, Marianne C., additional, Bots, Michiel L., additional, Drop, Adriaan C. A. D., additional, Plaisier, Loes, additional, Melchers, Rowena C. A., additional, Seelen, Marc A. J., additional, Sanders, Jan Stephan, additional, Hepkema, Bouke G., additional, Lambeck, Annechien J. A., additional, Bungener, Laura B., additional, Roozendaal, Caroline, additional, Tilanus, Marcel G. J., additional, Voorter, Christina E., additional, Wieten, Lotte, additional, van Duijnhoven, Elly M., additional, Gelens, Mariëlle A. C. J., additional, Christiaans, Maarten H. L., additional, van Ittersum, Frans J., additional, Nurmohamed, Shaikh A., additional, Lardy, Neubury M., additional, Swelsen, Wendy, additional, van der Pant, Karlijn A. M. I., additional, van der Weerd, Neelke C., additional, ten Berge, Ineke J. M., additional, Hoitsma, Andries, additional, van der Boog, Paul J. M., additional, de Fijter, Johan W., additional, Betjes, Michiel G. H., additional, Roelen, Dave L., additional, Claas, Frans H., additional, Bemelman, Frederike J., additional, Senev, Aleksandar, additional, Naesens, Maarten, additional, Heidt, Sebastiaan, additional, and Otten, Henny G., additional
- Published
- 2024
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3. Ellipro scores of donor epitope specific HLA antibodies are not associated with kidney graft survival.
- Author
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Kardol‐Hoefnagel, Tineke, Senejohnny, Danial Mohammadi, Kamburova, Elena G., Wisse, Bram W., Gruijters, Maartje L., Joosten, Irma, Allebes, Wil A., van der Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., van Reekum, Franka E., van Zuilen, Arjan D., Verhaar, Marianne C., Drop, Adriaan C. A. D., Plaisier, Loes, Melchers, Rowena C. A., Seelen, Marc A. J., and Sanders, Jan Stephan
- Subjects
IMMUNOGLOBULINS ,GRAFT survival ,KIDNEYS ,KIDNEY transplantation - Abstract
In kidney transplantation, donor HLA antibodies are a risk factor for graft loss. Accessibility of donor eplets for HLA antibodies is predicted by the ElliPro score. The clinical usefulness of those scores in relation to transplant outcome is unknown. In a large Dutch kidney transplant cohort, Ellipro scores of pretransplant donor antibodies that can be assigned to known eplets (donor epitope specific HLA antibodies [DESAs]) were compared between early graft failure and long surviving deceased donor transplants. We did not observe a significant Ellipro score difference between the two cohorts, nor significant differences in graft survival between transplants with DESAs having high versus low total Ellipro scores. We conclude that Ellipro scores cannot be used to identify DESAs associated with early versus late kidney graft loss in deceased donor transplants. [ABSTRACT FROM AUTHOR]
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- 2024
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4. T-Cell Epitopes Shared Between Immunizing HLA and Donor HLA Associate With Graft Failure After Kidney Transplantation
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Peereboom, Emma T. M., primary, Matern, Benedict M., additional, Tomosugi, Toshihide, additional, Niemann, Matthias, additional, Drylewicz, Julia, additional, Joosten, Irma, additional, Allebes, Wil A., additional, van der Meer, Arnold, additional, Hilbrands, Luuk B., additional, Baas, Marije C., additional, van Reekum, Franka E., additional, Verhaar, Marianne C., additional, Kamburova, Elena G., additional, Seelen, Marc A. J., additional, Sanders, Jan Stephan, additional, Hepkema, Bouke G., additional, Lambeck, Annechien J., additional, Bungener, Laura B., additional, Roozendaal, Caroline, additional, Tilanus, Marcel G. J., additional, Voorter, Christien E., additional, Wieten, Lotte, additional, van Duijnhoven, Elly M., additional, Gelens, Mariëlle A. C. J., additional, Christiaans, Maarten H. L., additional, van Ittersum, Frans J., additional, Nurmohamed, Azam, additional, Lardy, Neubury M., additional, Swelsen, Wendy, additional, van der Pant, Karlijn A., additional, van der Weerd, Neelke C., additional, ten Berge, Ineke J. M., additional, Bemelman, Fréderike J., additional, de Vries, Aiko P. J., additional, de Fijter, Johan W., additional, Betjes, Michiel G. H., additional, Roelen, Dave L., additional, Claas, Frans H., additional, Otten, Henny G., additional, Heidt, Sebastiaan, additional, van Zuilen, Arjan D., additional, Kobayashi, Takaaki, additional, Geneugelijk, Kirsten, additional, and Spierings, Eric, additional
- Published
- 2021
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5. T-Cell Epitopes Shared Between Immunizing HLA and Donor HLA Associate With Graft Failure After Kidney Transplantation
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CTI Spierings, CTI Computational Immunology Core, Infection & Immunity, CTI Borghans, MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, CDL Patiëntenzorg MI, Cancer, Peereboom, Emma T M, Matern, Benedict M, Tomosugi, Toshihide, Niemann, Matthias, Drylewicz, Julia, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, van Reekum, Franka E, Verhaar, Marianne C, Kamburova, Elena G, Seelen, Marc A J, Sanders, Jan Stephan, Hepkema, Bouke G, Lambeck, Annechien J, Bungener, Laura B, Roozendaal, Caroline, Tilanus, Marcel G J, Voorter, Christien E, Wieten, Lotte, van Duijnhoven, Elly M, Gelens, Mariëlle A C J, Christiaans, Maarten H L, van Ittersum, Frans J, Nurmohamed, Azam, Lardy, Neubury M, Swelsen, Wendy, van der Pant, Karlijn A, van der Weerd, Neelke C, Ten Berge, Ineke J M, Bemelman, Fréderike J, de Vries, Aiko P J, de Fijter, Johan W, Betjes, Michiel G H, Roelen, Dave L, Claas, Frans H, Otten, Henny G, Heidt, Sebastiaan, van Zuilen, Arjan D, Kobayashi, Takaaki, Geneugelijk, Kirsten, Spierings, Eric, CTI Spierings, CTI Computational Immunology Core, Infection & Immunity, CTI Borghans, MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, CDL Patiëntenzorg MI, Cancer, Peereboom, Emma T M, Matern, Benedict M, Tomosugi, Toshihide, Niemann, Matthias, Drylewicz, Julia, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, van Reekum, Franka E, Verhaar, Marianne C, Kamburova, Elena G, Seelen, Marc A J, Sanders, Jan Stephan, Hepkema, Bouke G, Lambeck, Annechien J, Bungener, Laura B, Roozendaal, Caroline, Tilanus, Marcel G J, Voorter, Christien E, Wieten, Lotte, van Duijnhoven, Elly M, Gelens, Mariëlle A C J, Christiaans, Maarten H L, van Ittersum, Frans J, Nurmohamed, Azam, Lardy, Neubury M, Swelsen, Wendy, van der Pant, Karlijn A, van der Weerd, Neelke C, Ten Berge, Ineke J M, Bemelman, Fréderike J, de Vries, Aiko P J, de Fijter, Johan W, Betjes, Michiel G H, Roelen, Dave L, Claas, Frans H, Otten, Henny G, Heidt, Sebastiaan, van Zuilen, Arjan D, Kobayashi, Takaaki, Geneugelijk, Kirsten, and Spierings, Eric
- Published
- 2021
6. An interleukin 6‐based genetic risk score strengthened with interleukin 10 polymorphisms associated with long‐term kidney allograft outcomes
- Author
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Eskandari, Siawosh K., Gaya da Costa, Mariana, Faria, Bernardo, Petr, Vojtech, Azzi, Jamil R., Berger, Stefan P., Seelen, Marc A. J., Damman, Jeffrey, and Poppelaars, Felix
- Abstract
Of all kidney transplants, half are still lost in the first decade after transplantation. Here, using genetics, we probed whether interleukin 6 (IL‐6) could be a target in kidney transplantation to improve graft survival. Additionally, we investigated if a genetic risk score (GRS) based on IL6and IL10variants could improve prognostication of graft loss. In a prospective cohort study, DNA of 1271 donor‐recipient kidney transplant pairs was analyzed for the presence of IL6, IL6R, IL10, IL10RA,and IL10RBvariants. These polymorphisms and their GRS were then associated with 15‐year death‐censored allograft survival. The C|C‐genotype of the IL6polymorphism in donor kidneys and the combined C|C‐genotype in donor‐recipient pairs were both associated with a reduced risk of graft loss (p= .043 and p= .042, respectively). Additionally, the GRS based on IL6, IL6R, IL10, IL10RA,and IL10RBvariants was independently associated with the risk of graft loss (HR 1.53, 95%‐CI [1.32–1.84]; p< .001). Notably, the GRS improved risk stratification and prediction of graft loss beyond the level of contemporary clinical markers. Our findings reveal the merits of a polygenic IL‐6‐based risk score strengthened with IL‐10‐ polymorphisms for the prognostication and risk stratification of late graft failure in kidney transplantation.
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- 2022
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7. Regulatory T cells engineered with TCR signaling–responsive IL-2 nanogels suppress alloimmunity in sites of antigen encounter
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Eskandari, Siawosh K., primary, Sulkaj, Ina, additional, Melo, Mariane B., additional, Li, Na, additional, Allos, Hazim, additional, Alhaddad, Juliano B., additional, Kollar, Branislav, additional, Borges, Thiago J., additional, Eskandari, Arach S., additional, Zinter, Max A., additional, Cai, Songjie, additional, Assaker, Jean Pierre, additional, Choi, John Y., additional, Al Dulaijan, Basmah S., additional, Mansouri, Amr, additional, Haik, Yousef, additional, Tannous, Bakhos A., additional, van Son, Willem J., additional, Leuvenink, Henri G. D., additional, Pomahac, Bohdan, additional, Riella, Leonardo V., additional, Tang, Li, additional, Seelen, Marc A. J., additional, Irvine, Darrell J., additional, and Azzi, Jamil R., additional
- Published
- 2020
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8. Properdin Pattern Recognition on Proximal Tubular Cells Is Heparan Sulfate/Syndecan-1 but Not C3b Dependent and Can Be Blocked by Tick Protein Salp20
- Author
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Lammerts, Rosa G. M., primary, Talsma, Ditmer T., additional, Dam, Wendy A., additional, Daha, Mohamed R., additional, Seelen, Marc A. J., additional, Berger, Stefan P., additional, and van den Born, Jacob, additional
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- 2020
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9. Dysregulation of Complement Activation and Placental Dysfunction: A Potential Target to Treat Preeclampsia?
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Pierik, E., primary, Prins, Jelmer R., additional, van Goor, Harry, additional, Dekker, Gustaaf A., additional, Daha, Mohamed R., additional, Seelen, Marc A. J., additional, and Scherjon, Sicco A., additional
- Published
- 2020
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10. Antibodies against ARHGDIB are associated with long-term kidney graft loss
- Author
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Kamburova, Elena G, Gruijters, Maartje L, Kardol-Hoefnagel, Tineke, Wisse, Bram W, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, Spierings, Eric, Hack, Cornelis E, van Reekum, Franka E, van Zuilen, Arjan D, Verhaar, Marianne C, Bots, Michiel L, Drop, Adriaan C A D, Plaisier, Loes, Melchers, Rowena C A, Seelen, Marc A J, Sanders, Jan Stephan, Hepkema, Bouke G, Lambeck, Annechien J A, Bungener, Laura B, Roozendaal, Caroline, Tilanus, Marcel G J, Voorter, Christina E, Wieten, Lotte, van Duijnhoven, Elly M, Gelens, Mariëlle A C J, Christiaans, Maarten H L, van Ittersum, Frans J, Nurmohamed, Shaikh A, Lardy, Neubury M, Swelsen, Wendy, van der Pant, Karlijn A M I, van der Weerd, Neelke C, Ten Berge, Ineke J M, Hoitsma, Andries, van der Boog, Paul J M, de Fijter, Johan W, Betjes, Michiel G H, Heidt, Sebastiaan, Roelen, Dave L, Claas, Frans H, Bemelman, Frederike J, Otten, Henny G, Kamburova, Elena G, Gruijters, Maartje L, Kardol-Hoefnagel, Tineke, Wisse, Bram W, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, Spierings, Eric, Hack, Cornelis E, van Reekum, Franka E, van Zuilen, Arjan D, Verhaar, Marianne C, Bots, Michiel L, Drop, Adriaan C A D, Plaisier, Loes, Melchers, Rowena C A, Seelen, Marc A J, Sanders, Jan Stephan, Hepkema, Bouke G, Lambeck, Annechien J A, Bungener, Laura B, Roozendaal, Caroline, Tilanus, Marcel G J, Voorter, Christina E, Wieten, Lotte, van Duijnhoven, Elly M, Gelens, Mariëlle A C J, Christiaans, Maarten H L, van Ittersum, Frans J, Nurmohamed, Shaikh A, Lardy, Neubury M, Swelsen, Wendy, van der Pant, Karlijn A M I, van der Weerd, Neelke C, Ten Berge, Ineke J M, Hoitsma, Andries, van der Boog, Paul J M, de Fijter, Johan W, Betjes, Michiel G H, Heidt, Sebastiaan, Roelen, Dave L, Claas, Frans H, Bemelman, Frederike J, and Otten, Henny G
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- 2019
11. A paired kidney analysis on the impact of pre-transplant anti-HLA antibodies on graft survival
- Author
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Michielsen, Laura A, Wisse, Bram W, Kamburova, Elena G, Verhaar, Marianne C, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, Spierings, Eric, Hack, Erik, van Reekum, Franka E, Bots, Michiel L, Drop, Adriaan C A D, Plaisier, Loes, Seelen, Marc A J, Sanders, Jan-Stephan F, Hepkema, Bouke G, Lambeck, Annechien J, Bungener, Laura B, Roozendaal, Caroline, Tilanus, Marcel G J, Voorter, Christien E, Wieten, Lotte, van Duijnhoven, Elizabeth M, Gelens, Mariëlle, Christiaans, Maarten H L, van Ittersum, Frans J, Nurmohamed, Shaikh A, Lardy, Neubury M, Swelsen, Wendy, van der Pant, Karlijn A, van der Weerd, Neelke C, Ten Berge, Ineke J M, Bemelman, Frederike J, Hoitsma, Andries, van der Boog, Paul J M, de Fijter, Johan W, Betjes, Michiel G H, Heidt, Sebastiaan, Roelen, Dave L, Claas, Frans H, Otten, Henderikus G, van Zuilen, Arjan D, Michielsen, Laura A, Wisse, Bram W, Kamburova, Elena G, Verhaar, Marianne C, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, Spierings, Eric, Hack, Erik, van Reekum, Franka E, Bots, Michiel L, Drop, Adriaan C A D, Plaisier, Loes, Seelen, Marc A J, Sanders, Jan-Stephan F, Hepkema, Bouke G, Lambeck, Annechien J, Bungener, Laura B, Roozendaal, Caroline, Tilanus, Marcel G J, Voorter, Christien E, Wieten, Lotte, van Duijnhoven, Elizabeth M, Gelens, Mariëlle, Christiaans, Maarten H L, van Ittersum, Frans J, Nurmohamed, Shaikh A, Lardy, Neubury M, Swelsen, Wendy, van der Pant, Karlijn A, van der Weerd, Neelke C, Ten Berge, Ineke J M, Bemelman, Frederike J, Hoitsma, Andries, van der Boog, Paul J M, de Fijter, Johan W, Betjes, Michiel G H, Heidt, Sebastiaan, Roelen, Dave L, Claas, Frans H, Otten, Henderikus G, and van Zuilen, Arjan D
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- 2019
12. A paired kidney analysis on the impact of pre-transplant anti-HLA antibodies on graft survival
- Author
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MS Nefrologie, Infection & Immunity, CTI Otten, Nefro Vasculaire Geneeskunde, Circulatory Health, Regenerative Medicine and Stem Cells, CDL Patiëntenzorg MI, CDL Celdiagnostiek, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, CTI, CDL unit Immunoserologie, Michielsen, Laura A, Wisse, Bram W, Kamburova, Elena G, Verhaar, Marianne C, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, Spierings, Eric, Hack, Erik, van Reekum, Franka E, Bots, Michiel L, Drop, Adriaan C A D, Plaisier, Loes, Seelen, Marc A J, Sanders, Jan-Stephan F, Hepkema, Bouke G, Lambeck, Annechien J, Bungener, Laura B, Roozendaal, Caroline, Tilanus, Marcel G J, Voorter, Christien E, Wieten, Lotte, van Duijnhoven, Elizabeth M, Gelens, Mariëlle, Christiaans, Maarten H L, van Ittersum, Frans J, Nurmohamed, Shaikh A, Lardy, Neubury M, Swelsen, Wendy, van der Pant, Karlijn A, van der Weerd, Neelke C, Ten Berge, Ineke J M, Bemelman, Frederike J, Hoitsma, Andries, van der Boog, Paul J M, de Fijter, Johan W, Betjes, Michiel G H, Heidt, Sebastiaan, Roelen, Dave L, Claas, Frans H, Otten, Henderikus G, van Zuilen, Arjan D, MS Nefrologie, Infection & Immunity, CTI Otten, Nefro Vasculaire Geneeskunde, Circulatory Health, Regenerative Medicine and Stem Cells, CDL Patiëntenzorg MI, CDL Celdiagnostiek, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, CTI, CDL unit Immunoserologie, Michielsen, Laura A, Wisse, Bram W, Kamburova, Elena G, Verhaar, Marianne C, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, Spierings, Eric, Hack, Erik, van Reekum, Franka E, Bots, Michiel L, Drop, Adriaan C A D, Plaisier, Loes, Seelen, Marc A J, Sanders, Jan-Stephan F, Hepkema, Bouke G, Lambeck, Annechien J, Bungener, Laura B, Roozendaal, Caroline, Tilanus, Marcel G J, Voorter, Christien E, Wieten, Lotte, van Duijnhoven, Elizabeth M, Gelens, Mariëlle, Christiaans, Maarten H L, van Ittersum, Frans J, Nurmohamed, Shaikh A, Lardy, Neubury M, Swelsen, Wendy, van der Pant, Karlijn A, van der Weerd, Neelke C, Ten Berge, Ineke J M, Bemelman, Frederike J, Hoitsma, Andries, van der Boog, Paul J M, de Fijter, Johan W, Betjes, Michiel G H, Heidt, Sebastiaan, Roelen, Dave L, Claas, Frans H, Otten, Henderikus G, and van Zuilen, Arjan D
- Published
- 2019
13. Antibodies against ARHGDIB are associated with long-term kidney graft loss
- Author
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CTI Otten, Infection & Immunity, CDL Patiëntenzorg MI, CTI, MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, CDL Celdiagnostiek, CDL unit Immunoserologie, Kamburova, Elena G, Gruijters, Maartje L, Kardol-Hoefnagel, Tineke, Wisse, Bram W, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, Spierings, Eric, Hack, Cornelis E, van Reekum, Franka E, van Zuilen, Arjan D, Verhaar, Marianne C, Bots, Michiel L, Drop, Adriaan C A D, Plaisier, Loes, Melchers, Rowena C A, Seelen, Marc A J, Sanders, Jan Stephan, Hepkema, Bouke G, Lambeck, Annechien J A, Bungener, Laura B, Roozendaal, Caroline, Tilanus, Marcel G J, Voorter, Christina E, Wieten, Lotte, van Duijnhoven, Elly M, Gelens, Mariëlle A C J, Christiaans, Maarten H L, van Ittersum, Frans J, Nurmohamed, Shaikh A, Lardy, Neubury M, Swelsen, Wendy, van der Pant, Karlijn A M I, van der Weerd, Neelke C, Ten Berge, Ineke J M, Hoitsma, Andries, van der Boog, Paul J M, de Fijter, Johan W, Betjes, Michiel G H, Heidt, Sebastiaan, Roelen, Dave L, Claas, Frans H, Bemelman, Frederike J, Otten, Henny G, CTI Otten, Infection & Immunity, CDL Patiëntenzorg MI, CTI, MS Nefrologie, Circulatory Health, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, CDL Celdiagnostiek, CDL unit Immunoserologie, Kamburova, Elena G, Gruijters, Maartje L, Kardol-Hoefnagel, Tineke, Wisse, Bram W, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, Spierings, Eric, Hack, Cornelis E, van Reekum, Franka E, van Zuilen, Arjan D, Verhaar, Marianne C, Bots, Michiel L, Drop, Adriaan C A D, Plaisier, Loes, Melchers, Rowena C A, Seelen, Marc A J, Sanders, Jan Stephan, Hepkema, Bouke G, Lambeck, Annechien J A, Bungener, Laura B, Roozendaal, Caroline, Tilanus, Marcel G J, Voorter, Christina E, Wieten, Lotte, van Duijnhoven, Elly M, Gelens, Mariëlle A C J, Christiaans, Maarten H L, van Ittersum, Frans J, Nurmohamed, Shaikh A, Lardy, Neubury M, Swelsen, Wendy, van der Pant, Karlijn A M I, van der Weerd, Neelke C, Ten Berge, Ineke J M, Hoitsma, Andries, van der Boog, Paul J M, de Fijter, Johan W, Betjes, Michiel G H, Heidt, Sebastiaan, Roelen, Dave L, Claas, Frans H, Bemelman, Frederike J, and Otten, Henny G
- Published
- 2019
14. Complement Activation in Autoimmune Bullous Dermatoses: A Comprehensive Review
- Author
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Edwards, Gareth, primary, Diercks, Gilles F. H., additional, Seelen, Marc A. J., additional, Horvath, Barbara, additional, van Doorn, Martijn B. A., additional, and Damman, Jeffrey, additional
- Published
- 2019
- Full Text
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15. Development and Validation of a Multiplex Non-HLA Antibody Assay for the Screening of Kidney Transplant Recipients
- Author
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Kamburova, Elena G., primary, Kardol-Hoefnagel, Tineke, additional, Wisse, Bram W., additional, Joosten, Irma, additional, Allebes, Wil A., additional, van der Meer, Arnold, additional, Hilbrands, Luuk B., additional, Baas, Marije C., additional, Spierings, Eric, additional, Hack, Cornelis E., additional, van Reekum, Franka E., additional, van Zuilen, Arjan D., additional, Verhaar, Marianne C., additional, Bots, Michiel L., additional, Drop, Adriaan C. A. D., additional, Plaisier, Loes, additional, Meeldijk, Jan, additional, Bovenschen, Niels, additional, Seelen, Marc A. J., additional, Sanders, Jan Stephan, additional, Hepkema, Bouke G., additional, Lambeck, Annechien J. A., additional, Bungener, Laura B., additional, Roozendaal, Caroline, additional, Tilanus, Marcel G. J., additional, Voorter, Christina E., additional, Wieten, Lotte, additional, van Duijnhoven, Elly M., additional, Gelens, Mariëlle A. C. J., additional, Christiaans, Maarten H. L., additional, van Ittersum, Frans J., additional, Nurmohamed, Shaikh A., additional, Lardy, Neubury M., additional, Swelsen, Wendy, additional, van der Pant, Karlijn A. M. I., additional, van der Weerd, Neelke C., additional, ten Berge, Ineke J. M., additional, Bemelman, Frederike J., additional, van der Boog, Paul J. M., additional, de Fijter, Johan W., additional, Betjes, Michiel G. H., additional, Heidt, Sebastiaan, additional, Roelen, Dave L., additional, Claas, Frans H., additional, and Otten, Henny G., additional
- Published
- 2018
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16. Effect of initial immunosuppression on long-term kidney transplant outcome in immunological low-risk patients
- Author
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Michielsen, Laura A, primary, van Zuilen, Arjan D, additional, Verhaar, Marianne C, additional, Wisse, Bram W, additional, Kamburova, Elena G, additional, Joosten, Irma, additional, Allebes, Wil A, additional, van der Meer, Arnold, additional, Baas, Marije C, additional, Spierings, Eric, additional, Hack, Cornelis E, additional, van Reekum, Franka E, additional, Bots, Michiel L, additional, Drop, Adriaan C A D, additional, Plaisier, Loes, additional, Seelen, Marc A J, additional, Sanders, Jan-Stephan F, additional, Hepkema, Bouke G, additional, Lambeck, Annechien J, additional, Bungener, Laura B, additional, Roozendaal, Caroline, additional, Tilanus, Marcel G J, additional, Voorter, Christien E, additional, Wieten, Lotte, additional, van Duijnhoven, Elizabeth M, additional, Gelens, Mariëlle A C J, additional, Christiaans, Maarten H L, additional, van Ittersum, Frans J, additional, Nurmohamed, Shaikh A, additional, Lardy, Neubury M, additional, Swelsen, Wendy, additional, van der Pant, Karlijn A, additional, van der Weerd, Neelke C, additional, ten Berge, Ineke J M, additional, Bemelman, Frederike J, additional, Hoitsma, Andries, additional, van der Boog, Paul J M, additional, de Fijter, Johan W, additional, Betjes, Michiel G H, additional, Heidt, Sebastiaan, additional, Roelen, Dave L, additional, Claas, Frans H, additional, Otten, Henderikus G, additional, and Hilbrands, Luuk B, additional
- Published
- 2018
- Full Text
- View/download PDF
17. A paired kidney analysis on the impact of pre-transplant anti-HLA antibodies on graft survival
- Author
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Michielsen, Laura A, primary, Wisse, Bram W, additional, Kamburova, Elena G, additional, Verhaar, Marianne C, additional, Joosten, Irma, additional, Allebes, Wil A, additional, van der Meer, Arnold, additional, Hilbrands, Luuk B, additional, Baas, Marije C, additional, Spierings, Eric, additional, Hack, Cornelis E, additional, van Reekum, Franka E, additional, Bots, Michiel L, additional, Drop, Adriaan C A D, additional, Plaisier, Loes, additional, Seelen, Marc A J, additional, Sanders, Jan-Stephan F, additional, Hepkema, Bouke G, additional, Lambeck, Annechien J, additional, Bungener, Laura B, additional, Roozendaal, Caroline, additional, Tilanus, Marcel G J, additional, Voorter, Christien E, additional, Wieten, Lotte, additional, van Duijnhoven, Elizabeth M, additional, Gelens, Mariëlle, additional, Christiaans, Maarten H L, additional, van Ittersum, Frans J, additional, Nurmohamed, Shaikh A, additional, Lardy, Neubury M, additional, Swelsen, Wendy, additional, van der Pant, Karlijn A, additional, van der Weerd, Neelke C, additional, ten Berge, Ineke J M, additional, Bemelman, Frederike J, additional, Hoitsma, Andries, additional, van der Boog, Paul J M, additional, de Fijter, Johan W, additional, Betjes, Michiel G H, additional, Heidt, Sebastiaan, additional, Roelen, Dave L, additional, Claas, Frans H, additional, Otten, Henderikus G, additional, and van Zuilen, Arjan D, additional
- Published
- 2018
- Full Text
- View/download PDF
18. Complement Activation in Inflammatory Skin Diseases
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Giang, Jenny, primary, Seelen, Marc A. J., additional, van Doorn, Martijn B. A., additional, Rissmann, Robert, additional, Prens, Errol P., additional, and Damman, Jeffrey, additional
- Published
- 2018
- Full Text
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19. PIRCHE-II Is Related to Graft Failure after Kidney Transplantation
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Geneugelijk, Kirsten, primary, Niemann, Matthias, additional, Drylewicz, Julia, additional, van Zuilen, Arjan D., additional, Joosten, Irma, additional, Allebes, Wil A., additional, van der Meer, Arnold, additional, Hilbrands, Luuk B., additional, Baas, Marije C., additional, Hack, C. Erik, additional, van Reekum, Franka E., additional, Verhaar, Marianne C., additional, Kamburova, Elena G., additional, Bots, Michiel L., additional, Seelen, Marc A. J., additional, Sanders, Jan Stephan, additional, Hepkema, Bouke G., additional, Lambeck, Annechien J., additional, Bungener, Laura B., additional, Roozendaal, Caroline, additional, Tilanus, Marcel G. J., additional, Vanderlocht, Joris, additional, Voorter, Christien E., additional, Wieten, Lotte, additional, van Duijnhoven, Elly M., additional, Gelens, Mariëlle, additional, Christiaans, Maarten H. L., additional, van Ittersum, Frans J., additional, Nurmohamed, Azam, additional, Lardy, Junior N. M., additional, Swelsen, Wendy, additional, van der Pant, Karlijn A., additional, van der Weerd, Neelke C., additional, ten Berge, Ineke J. M., additional, Bemelman, Fréderike J., additional, Hoitsma, Andries, additional, van der Boog, Paul J. M., additional, de Fijter, Johan W., additional, Betjes, Michiel G. H., additional, Heidt, Sebastiaan, additional, Roelen, Dave L., additional, Claas, Frans H., additional, Otten, Henny G., additional, and Spierings, Eric, additional
- Published
- 2018
- Full Text
- View/download PDF
20. Distinct in vitro Complement Activation by Various Intravenous Iron Preparations
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Hempel, Julia Cordelia, Poppelaars, Felix, da Costa, Mariana Gaya, Franssen, Casper F. M., de Vlaam, Thomas P G, Daha, Mohamed R., Berger, Stefan P, Seelen, Marc A. J., Gaillard, Carlo A. J. M., Hempel, Julia Cordelia, Poppelaars, Felix, da Costa, Mariana Gaya, Franssen, Casper F. M., de Vlaam, Thomas P G, Daha, Mohamed R., Berger, Stefan P, Seelen, Marc A. J., and Gaillard, Carlo A. J. M.
- Published
- 2017
21. Distinct in vitro Complement Activation by Various Intravenous Iron Preparations
- Author
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DIGD-Medisch 1, Hempel, Julia Cordelia, Poppelaars, Felix, da Costa, Mariana Gaya, Franssen, Casper F. M., de Vlaam, Thomas P G, Daha, Mohamed R., Berger, Stefan P, Seelen, Marc A. J., Gaillard, Carlo A. J. M., DIGD-Medisch 1, Hempel, Julia Cordelia, Poppelaars, Felix, da Costa, Mariana Gaya, Franssen, Casper F. M., de Vlaam, Thomas P G, Daha, Mohamed R., Berger, Stefan P, Seelen, Marc A. J., and Gaillard, Carlo A. J. M.
- Published
- 2017
22. Antibodies against ARHGDIBare associated with long‐term kidney graft loss
- Author
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Kamburova, Elena G., Gruijters, Maartje L., Kardol‐Hoefnagel, Tineke, Wisse, Bram W., Joosten, Irma, Allebes, Wil A., Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., Reekum, Franka E., Zuilen, Arjan D., Verhaar, Marianne C., Bots, Michiel L., Drop, Adriaan C. A. D., Plaisier, Loes, Melchers, Rowena C. A., Seelen, Marc A. J., Sanders, Jan Stephan, Hepkema, Bouke G., Lambeck, Annechien J. A., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G. J., Voorter, Christina E., Wieten, Lotte, Duijnhoven, Elly M., Gelens, Mariëlle A. C. J., Christiaans, Maarten H. L., van Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, Pant, Karlijn A. M. I., Weerd, Neelke C., Berge, Ineke J. M., Hoitsma, Andries, Boog, Paul J. M., de Fijter, Johan W., Betjes, Michiel G. H., Heidt, Sebastiaan, Roelen, Dave L., Claas, Frans H., Bemelman, Frederike J., and Otten, Henny G.
- Abstract
The clinical significance of non‐HLAantibodies on renal allograft survival is a matter of debate, due to differences in reported results and lack of large‐scale studies incorporating analysis of multiple non‐HLAantibodies simultaneously. We developed a multiplex non‐HLAantibody assay against 14 proteins highly expressed in the kidney. In this study, the presence of pretransplant non‐HLAantibodies was correlated to renal allograft survival in a nationwide cohort of 4770 recipients transplanted between 1995 and 2006. Autoantibodies against Rho GDP‐dissociation inhibitor 2 (ARHGDIB) were significantly associated with graft loss in recipients transplanted with a deceased‐donor kidney (N = 3276) but not in recipients of a living‐donor kidney (N = 1496). At 10 years after deceased‐donor transplantation, recipients with anti‐ARHGDIBantibodies (94/3276 = 2.9%) had a 13% lower death‐censored covariate‐adjusted graft survival compared to the anti‐ARHGDIB‐negative (3182/3276 = 97.1%) population (hazard ratio 1.82; 95% confidence interval, 1.32‐2.53; P= .0003). These antibodies occur independently from donor‐specific anti‐HLA antibodies (DSA) or other non‐HLAantibodies investigated. No significant relations with graft loss were found for the other 13 non‐HLAantibodies. We suggest that pretransplant risk assessment can be improved by measuring anti‐ARHGDIBantibodies in all patients awaiting deceased‐donor transplantation. From a multicenter evaluation of kidney transplants, the authors report that the pretransplant presence of autoantibodies against ARHGDIB are associated with long‐term graft loss in recipients transplanted with a deceased donor kidney, independent from donor‐specific HLA antibodies.
- Published
- 2019
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23. Effect of initial immunosuppression on long-term kidney transplant outcome in immunological low-risk patients.
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Michielsen, Laura A, Zuilen, Arjan D van, Verhaar, Marianne C, Wisse, Bram W, Kamburova, Elena G, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Baas, Marije C, Spierings, Eric, Hack, Cornelis E, Reekum, Franka E van, Bots, Michiel L, Drop, Adriaan C A D, Plaisier, Loes, Seelen, Marc A J, Sanders, Jan-Stephan F, Hepkema, Bouke G, Lambeck, Annechien J, and Bungener, Laura B
- Subjects
KIDNEY transplantation - Abstract
Background Few studies have evaluated the effect of different immunosuppressive strategies on long-term kidney transplant outcomes. Moreover, as they were usually based on historical data, it was not possible to account for the presence of pretransplant donor-specific human-leukocyte antigen antibodies (DSA), a currently recognized risk marker for impaired graft survival. The aim of this study was to evaluate to what extent frequently used initial immunosuppressive therapies increase graft survival in immunological low-risk patients. Methods We performed an analysis on the PROCARE cohort, a Dutch multicentre study including all transplantations performed in the Netherlands between 1995 and 2005 with available pretransplant serum (n = 4724). All sera were assessed for the presence of DSA by a luminex single-antigen bead assay. Patients with a previous kidney transplantation, pretransplant DSA or receiving induction therapy were excluded from the analysis. Results Three regimes were used in over 200 patients: cyclosporine (CsA)/prednisolone (Pred) (n = 542), CsA/mycophenolate mofetil (MMF)/Pred (n = 857) and tacrolimus (TAC)/MMF/Pred (n = 811). Covariate-adjusted analysis revealed no significant differences in 10-year death-censored graft survival between patients on TAC/MMF/Pred therapy (79%) compared with patients on CsA/MMF/Pred (82%, P = 0.88) or CsA/Pred (79%, P = 0.21). However, 1-year rejection-free survival censored for death and failure unrelated to rejection was significantly higher for TAC/MMF/Pred (81%) when compared with CsA/MMF/Pred (67%, P < 0.0001) and CsA/Pred (64%, P < 0.0001). Conclusion These results suggest that in immunological low-risk patients excellent long-term kidney graft survival can be achieved irrespective of the type of initial immunosuppressive therapy (CsA or TAC; with or without MMF), despite differences in 1-year rejection-free survival. [ABSTRACT FROM AUTHOR]
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- 2019
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24. paired kidney analysis on the impact of pre-transplant anti-HLA antibodies on graft survival.
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Michielsen, Laura A, Wisse, Bram W, Kamburova, Elena G, Verhaar, Marianne C, Joosten, Irma, Allebes, Wil A, van der Meer, Arnold, Hilbrands, Luuk B, Baas, Marije C, Spierings, Eric, Hack, Cornelis E, Reekum, Franka E van, Bots, Michiel L, Drop, Adriaan C A D, Plaisier, Loes, Seelen, Marc A J, Sanders, Jan-Stephan F, Hepkema, Bouke G, Lambeck, Annechien J, and Bungener, Laura B
- Subjects
IMMUNOGLOBULINS ,KIDNEYS ,KIDNEY transplantation - Abstract
Background Pre-transplant donor-specific anti–human leucocyte antigen (HLA) antibodies (DSAs) are associated with impaired kidney graft survival while the clinical relevance of non-donor-specific anti-HLA antibodies (nDSAs) is more controversial. The aim of the present paired kidney graft study was to compare the clinical relevance of DSAs and nDSAs. Methods To eliminate donor and era-dependent factors, a post hoc paired kidney graft analysis was performed as part of a Dutch multicentre study evaluating all transplantations between 1995 and 2005 with available pre-transplant serum samples. Anti-HLA antibodies were detected with a Luminex single-antigen bead assay. Results Among 3237 deceased donor transplantations, we identified 115 recipient pairs receiving a kidney from the same donor with one recipient being DSA positive and the other without anti-HLA antibodies. Patients with pre-transplant DSAs had a significantly lower 10-year death-censored graft survival (55% versus 82%, P=0.0001). We identified 192 pairs with one recipient as nDSA positive (against Class I and/or II) and the other without anti-HLA antibodies. For the patients with nDSAs against either Class I or II, graft survival did not significantly differ compared with patients without anti-HLA antibodies (74% versus 77%, P
- Published
- 2019
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25. Erratum to: Strong predictive value of mannose-binding lectin levels for cardiovascular risk of hemodialysis patients
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Poppelaars, Felix, primary, Gaya da Costa, Mariana, additional, Berger, Stefan P., additional, Assa, Solmaz, additional, Meter-Arkema, Anita H., additional, Daha, Mohamed R., additional, van Son, Willem J., additional, Franssen, Casper F. M., additional, and Seelen, Marc A. J., additional
- Published
- 2016
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26. Strong predictive value of mannose-binding lectin levels for cardiovascular risk of hemodialysis patients
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Poppelaars, Felix, primary, Gaya da Costa, Mariana, additional, Berger, Stefan P., additional, Assa, Solmaz, additional, Meter-Arkema, Anita H., additional, Daha, Mohamed R., additional, van Son, Willem J., additional, Franssen, Casper F. M., additional, and Seelen, Marc A. J., additional
- Published
- 2016
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27. Allocation to highly sensitized patients based on acceptable mismatches results in low rejection rates comparable to nonsensitized patients
- Author
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Heidt, Sebastiaan, Haasnoot, Geert W., Witvliet, Marian D., Linden‐van Oevelen, Marissa J. H., Kamburova, Elena G., Wisse, Bram W., Joosten, Irma, Allebes, Wil A., Meer, Arnold, Hilbrands, Luuk B., Baas, Marije C., Spierings, Eric, Hack, Cornelis E., Reekum, Franka E., Zuilen, Arjan D., Verhaar, Marianne C., Bots, Michiel L., Drop, Adriaan C. A. D., Plaisier, Loes, Seelen, Marc A. J., Sanders, Jan‐Stephan, Hepkema, Bouke G., Lambeck, Annechien J. A., Bungener, Laura B., Roozendaal, Caroline, Tilanus, Marcel G. J., Voorter, Christina E., Wieten, Lotte, Duijnhoven, Elly M., Gelens, Marielle A.C.J., Christiaans, Maarten H. L., Ittersum, Frans J., Nurmohamed, Shaikh A., Lardy, Neubury M., Swelsen, Wendy, Pant, Karlijn A. M. I., Weerd, Neelke C., ten Berge, Ineke J. M., Bemelman, Frederike J., Hoitsma, Andries, Boog, Paul J. M., Fijter, Johan W., Betjes, Michiel G. H., Otten, Henny G., Roelen, Dave L., and Claas, Frans H. J.
- Abstract
Whereas regular allocation avoids unacceptable mismatches on the donor organ, allocation to highly sensitized patients within the Eurotransplant Acceptable Mismatch (AM) program is based on the patient's HLAphenotype plus acceptable antigens. These are HLAantigens to which the patient never made antibodies, as determined by extensive laboratory testing. AMpatients have superior long‐term graft survival compared with highly sensitized patients in regular allocation. Here, we questioned whether the AMprogram also results in lower rejection rates. From the PROCAREcohort, consisting of all Dutch kidney transplants in 1995‐2005, we selected deceased donor single transplants with a minimum of 1 HLAmismatch and determined the cumulative 6‐month rejection incidence for patients in AMor regular allocation. Additionally, we determined the effect of minimal matching criteria of 1 HLA‐B plus 1 HLA‐DR, or 2 HLA‐DRantigens on rejection incidence. AMpatients showed significantly lower rejection rates than highly immunized patients in regular allocation, comparable to nonsensitized patients, independent of other risk factors for rejection. In contrast to highly sensitized patients in regular allocation, minimal matching criteria did not affect rejection rates in AMpatients. Allocation based on acceptable antigens leads to relatively low‐risk transplants for highly sensitized patients with rejection rates similar to those of nonimmunized individuals. The authors show that kidney allocation to highly sensitized patients based on proven acceptable HLA antigens results in a significantly lower incidence of rejection episodes when compared to allocation based on the avoidance of unacceptable HLA antigens only.
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- 2019
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28. Assessment of Cotinine Reveals a Dose-Dependent Effect of Smoking Exposure on Long-term Outcomes After Renal Transplantation
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Hellemons, Merel E., primary, Sanders, Jan-Stephan F., additional, Seelen, Marc A. J., additional, Gans, Rijk O. B., additional, Muller Kobold, Anneke C., additional, van Son, Willem J., additional, Postmus, Douwe, additional, Navis, Gerjan J., additional, and Bakker, Stephan J. L., additional
- Published
- 2015
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29. Genetic loci influencing kidney function and chronic kidney disease.
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Chambers, John C, Zhang, Weihua, Lord, Graham M, van der Harst, Pim, Lawlor, Debbie A, Sehmi, Joban S., Gale, Daniel P, Wass, Mark N., Ahmadi, Kourosh R, Bakker, Stephan J L, Beckmann, Jacqui, Bilo, Henk J G, Bochud, Murielle, Brown, Morris J, Caulfield, Mark J, Connell, John M C, Cook, H Terence, Cotlarciuc, Ioana, Davey Smith, George, de Silva, Ranil, Deng, Guohong, Devuyst, Olivier, Dikkeschei, Lambert D, Dimkovic, Nada, Dockrell, Mark, Dominiczak, Anna, Ebrahim, Shah, Eggermann, Thomas, Farrall, Martin, Ferrucci, Luigi, Floege, Jurgen, Forouhi, Nita G, Gansevoort, Ron T, Han, Xijin, Hedblad, Bo, Homan van der Heide, Jaap J, Hepkema, Bouke G, Hernandez-Fuentes, Maria, Hypponen, Elina, Johnson, Toby, de Jong, Paul E, Kleefstra, Nanne, Lagou, Vasiliki, Lapsley, Marta, Li, Yun, Loos, Ruth J F, Luan, Jian'an, Luttropp, Karin, Maréchal, Céline, Melander, Olle, Munroe, Patricia B, Nordfors, Louise, Parsa, Afshin, Peltonen, Leena, Penninx, Brenda W, Perucha, Esperanza, Pouta, Anneli, Prokopenko, Inga, Roderick, Paul J, Ruokonen, Aimo, Samani, Nilesh J, Sanna, Serena, Schalling, Martin, Schlessinger, David, Schlieper, Georg, Seelen, Marc A J, Shuldiner, Alan R, Sjögren, Marketa, Smit, Johannes H, Snieder, Harold, Soranzo, Nicole, Spector, Timothy D, Stenvinkel, Peter, Sternberg, Michael J.E., Swaminathan, Ramasamyiyer, Tanaka, Toshiko, Ubink-Veltmaat, Lielith J, Uda, Manuela, Vollenweider, Peter, Wallace, Chris, Waterworth, Dawn M, Zerres, Klaus, Waeber, Gerard, Wareham, Nicholas J, Maxwell, Patrick H, McCarthy, Mark I, Jarvelin, Marjo-Riitta, Mooser, Vincent, Abecasis, Goncalo R, Lightstone, Liz, Scott, James, Navis, Gerjan, Elliott, Paul, Kooner, Jaspal S, Chambers, John C, Zhang, Weihua, Lord, Graham M, van der Harst, Pim, Lawlor, Debbie A, Sehmi, Joban S., Gale, Daniel P, Wass, Mark N., Ahmadi, Kourosh R, Bakker, Stephan J L, Beckmann, Jacqui, Bilo, Henk J G, Bochud, Murielle, Brown, Morris J, Caulfield, Mark J, Connell, John M C, Cook, H Terence, Cotlarciuc, Ioana, Davey Smith, George, de Silva, Ranil, Deng, Guohong, Devuyst, Olivier, Dikkeschei, Lambert D, Dimkovic, Nada, Dockrell, Mark, Dominiczak, Anna, Ebrahim, Shah, Eggermann, Thomas, Farrall, Martin, Ferrucci, Luigi, Floege, Jurgen, Forouhi, Nita G, Gansevoort, Ron T, Han, Xijin, Hedblad, Bo, Homan van der Heide, Jaap J, Hepkema, Bouke G, Hernandez-Fuentes, Maria, Hypponen, Elina, Johnson, Toby, de Jong, Paul E, Kleefstra, Nanne, Lagou, Vasiliki, Lapsley, Marta, Li, Yun, Loos, Ruth J F, Luan, Jian'an, Luttropp, Karin, Maréchal, Céline, Melander, Olle, Munroe, Patricia B, Nordfors, Louise, Parsa, Afshin, Peltonen, Leena, Penninx, Brenda W, Perucha, Esperanza, Pouta, Anneli, Prokopenko, Inga, Roderick, Paul J, Ruokonen, Aimo, Samani, Nilesh J, Sanna, Serena, Schalling, Martin, Schlessinger, David, Schlieper, Georg, Seelen, Marc A J, Shuldiner, Alan R, Sjögren, Marketa, Smit, Johannes H, Snieder, Harold, Soranzo, Nicole, Spector, Timothy D, Stenvinkel, Peter, Sternberg, Michael J.E., Swaminathan, Ramasamyiyer, Tanaka, Toshiko, Ubink-Veltmaat, Lielith J, Uda, Manuela, Vollenweider, Peter, Wallace, Chris, Waterworth, Dawn M, Zerres, Klaus, Waeber, Gerard, Wareham, Nicholas J, Maxwell, Patrick H, McCarthy, Mark I, Jarvelin, Marjo-Riitta, Mooser, Vincent, Abecasis, Goncalo R, Lightstone, Liz, Scott, James, Navis, Gerjan, Elliott, Paul, and Kooner, Jaspal S
- Abstract
Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.
- Published
- 2010
30. Genetic loci influencing kidney function and chronic kidney disease
- Author
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Chambers, John C, primary, Zhang, Weihua, additional, Lord, Graham M, additional, van der Harst, Pim, additional, Lawlor, Debbie A, additional, Sehmi, Joban S, additional, Gale, Daniel P, additional, Wass, Mark N, additional, Ahmadi, Kourosh R, additional, Bakker, Stephan J L, additional, Beckmann, Jacqui, additional, Bilo, Henk J G, additional, Bochud, Murielle, additional, Brown, Morris J, additional, Caulfield, Mark J, additional, Connell, John M C, additional, Cook, H Terence, additional, Cotlarciuc, Ioana, additional, Smith, George Davey, additional, de Silva, Ranil, additional, Deng, Guohong, additional, Devuyst, Olivier, additional, Dikkeschei, Lambert D, additional, Dimkovic, Nada, additional, Dockrell, Mark, additional, Dominiczak, Anna, additional, Ebrahim, Shah, additional, Eggermann, Thomas, additional, Farrall, Martin, additional, Ferrucci, Luigi, additional, Floege, Jurgen, additional, Forouhi, Nita G, additional, Gansevoort, Ron T, additional, Han, Xijin, additional, Hedblad, Bo, additional, van der Heide, Jaap J Homan, additional, Hepkema, Bouke G, additional, Hernandez-Fuentes, Maria, additional, Hypponen, Elina, additional, Johnson, Toby, additional, de Jong, Paul E, additional, Kleefstra, Nanne, additional, Lagou, Vasiliki, additional, Lapsley, Marta, additional, Li, Yun, additional, Loos, Ruth J F, additional, Luan, Jian'an, additional, Luttropp, Karin, additional, Maréchal, Céline, additional, Melander, Olle, additional, Munroe, Patricia B, additional, Nordfors, Louise, additional, Parsa, Afshin, additional, Peltonen, Leena, additional, Penninx, Brenda W, additional, Perucha, Esperanza, additional, Pouta, Anneli, additional, Prokopenko, Inga, additional, Roderick, Paul J, additional, Ruokonen, Aimo, additional, Samani, Nilesh J, additional, Sanna, Serena, additional, Schalling, Martin, additional, Schlessinger, David, additional, Schlieper, Georg, additional, Seelen, Marc A J, additional, Shuldiner, Alan R, additional, Sjögren, Marketa, additional, Smit, Johannes H, additional, Snieder, Harold, additional, Soranzo, Nicole, additional, Spector, Timothy D, additional, Stenvinkel, Peter, additional, Sternberg, Michael J E, additional, Swaminathan, Ramasamyiyer, additional, Tanaka, Toshiko, additional, Ubink-Veltmaat, Lielith J, additional, Uda, Manuela, additional, Vollenweider, Peter, additional, Wallace, Chris, additional, Waterworth, Dawn, additional, Zerres, Klaus, additional, Waeber, Gerard, additional, Wareham, Nicholas J, additional, Maxwell, Patrick H, additional, McCarthy, Mark I, additional, Jarvelin, Marjo-Riitta, additional, Mooser, Vincent, additional, Abecasis, Goncalo R, additional, Lightstone, Liz, additional, Scott, James, additional, Navis, Gerjan, additional, Elliott, Paul, additional, and Kooner, Jaspal S, additional
- Published
- 2010
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31. Gastrointestinal Symptoms in Kidney Transplant Recipients: What about Silent Sufferers?
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van Dijk, Marja, primary, Niesing, Jan, additional, van der Heide, Jaap J. Homan, additional, de Maar, Eltjo F., additional, Ploeg, Rutger J., additional, van Son, Willem J., additional, and Seelen, Marc A. J., additional
- Published
- 2010
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32. Association Between Donor MBL Promoter Haplotype and Graft Survival and the Development of BOS After Lung Transplantation
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Munster, Janna M., primary, van der Bij, Wim, additional, Breukink, Myrte B., additional, van der Steege, Gerrit, additional, Zuurman, Mike W., additional, Hepkema, Bouke G., additional, Verschuuren, Erik A. M., additional, van Son, Willem J., additional, and Seelen, Marc A. J., additional
- Published
- 2008
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33. Urinary Urea Excretion and Long-term Outcome After Renal Transplantation.
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Deetman, Petronella E., Said, M. Yusof, Kromhout, Daan, Dullaart, Robin P. F., Kootstra-Ros, Jenny E., Sanders, Jan-Stephan F., Seelen, Marc A. J., Gans, Rijk O. B., Navis, Gerjan, Joosten, Michel M., and Bakker, Stephan J. L.
- Published
- 2015
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34. CBS gene variants are associated with conditions characterized by ischemia
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Koning, Anne M., Holwerda, Kim M., Weedon-Fekjaer, Susanne M., Staff, Annetine C., Nolte, Ilja M., Lely, A. Titia, Seelen, Marc A. J., Faas, Marijke M., Leuvenink, Henri G. D., van Goor, Harry, Life Course Epidemiology (LCE), Reproductive Origins of Adult Health and Disease (ROAHD), Groningen Institute for Organ Transplantation (GIOT), Groningen Kidney Center (GKC), and Translational Immunology Groningen (TRIGR)
35. ABO-INCOMPATIBLE KIDNEY TRANSPLANTATION: A SINGLE CENTER EXPERIENCE
- Author
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Klooster, Astrid, Seelen, Marc A. J., Diepstra, Arjan, Sanders, Jan-Stephan F., Groningen Institute for Organ Transplantation (GIOT), Groningen Kidney Center (GKC), and Stem Cell Aging Leukemia and Lymphoma (SALL)
36. No Evident Systemic Terminal Complement Pathway Activation in Hidradenitis Suppurativa.
- Author
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Prens LM, Ardon CB, van Straalen KR, van der Zee HH, Seelen MAJ, Laman JD, Prens EP, Horváth B, and Damman J
- Subjects
- Adult, Case-Control Studies, Clinical Trials as Topic, Complement C5a immunology, Female, Hidradenitis Suppurativa blood, Humans, Male, Middle Aged, Complement Activation, Complement System Proteins, Hidradenitis Suppurativa immunology, Immunotherapy methods
- Published
- 2021
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37. Corrigendum to 'Propofol-based anaesthesia versus sevoflurane-based anaesthesia for living donor kidney transplantation: results of the VAPOR-1 randomized controlled trial' (Br J Anaesth 2017; 118: 720-32).
- Author
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Nieuwenhuijs-Moeke GJ, Nieuwenhuijs VB, Seelen MAJ, Berger SP, van den Heuvel MC, Burgerhof JGM, Ottens PJ, Ploeg RJ, Leuvenink HGD, and Struys MMRF
- Published
- 2021
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38. Dermal C4d Deposition and Neutrophil Alignment Along the Dermal-Epidermal Junction as a Diagnostic Adjunct for Hypocomplementemic Urticarial Vasculitis (Anti-C1q Vasculitis) and Underlying Systemic Disease.
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Damman J, Mooyaart AL, Seelen MAJ, and van Doorn MBA
- Subjects
- Adult, Autoantibodies immunology, Autoantigens immunology, Complement C1q immunology, Complement C4b immunology, Female, Humans, Lupus Erythematosus, Systemic immunology, Male, Middle Aged, Neutrophils immunology, Peptide Fragments immunology, Retrospective Studies, Complement C4b metabolism, Lupus Erythematosus, Systemic complications, Neutrophils pathology, Peptide Fragments metabolism, Vasculitis, Leukocytoclastic, Cutaneous immunology, Vasculitis, Leukocytoclastic, Cutaneous pathology
- Abstract
Urticarial vasculitis (UV) is a clinicopathologic entity characterized by persistent urticarial lesions with biopsy features of vasculitis. Currently, only certain clinical features such as arthralgia and serum complement concentrations are used to identify UV patients at risk for an underlying systemic disease. Hypocomplementemic urticarial vasculitis (HUV) is in contrast to normocomplementemic urticarial vasculitis (NUV), strongly associated with underlying systemic disease, especially systemic lupus erythematosus (SLE). The aim of this study was to find specific histopathological features associated with HUV and underlying systemic disease in UV. In addition, the use of complement C4d deposition in skin biopsies was evaluated as a diagnostic adjunct for HUV- and UV-associated systemic disease. In this retrospective study, the clinical, histopathological, and immunohistological (C4d) features of 43 patients with UV were compared between HUV and NUV and analyzed for association with UV-associated systemic disease. Eight of 43 patients with UV (19%) had hypocomplementemia. Patients with HUV showed a significantly higher number of perivascular neutrophils and lower number of eosinophils compared to NUV. Of all histopathological features, alignment of neutrophils along the dermal-epidermal junction (DEJ) and dermal granular C4d deposition were found to be strongly associated with HUV and underlying SLE. This study shows that both the alignment of neutrophils along the DEJ and dermal C4d deposition are strongly associated with HUV and SLE. Therefore, these (immuno)histopathological features can be used as an easy diagnostic adjunct for early detection of underlying systemic disease in UV.
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- 2020
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39. Antibodies against ARHGDIB are associated with long-term kidney graft loss.
- Author
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Kamburova EG, Gruijters ML, Kardol-Hoefnagel T, Wisse BW, Joosten I, Allebes WA, van der Meer A, Hilbrands LB, Baas MC, Spierings E, Hack CE, van Reekum FE, van Zuilen AD, Verhaar MC, Bots ML, Drop ACAD, Plaisier L, Melchers RCA, Seelen MAJ, Sanders JS, Hepkema BG, Lambeck AJA, Bungener LB, Roozendaal C, Tilanus MGJ, Voorter CE, Wieten L, van Duijnhoven EM, Gelens MACJ, Christiaans MHL, van Ittersum FJ, Nurmohamed SA, Lardy NM, Swelsen W, van der Pant KAMI, van der Weerd NC, Ten Berge IJM, Hoitsma A, van der Boog PJM, de Fijter JW, Betjes MGH, Heidt S, Roelen DL, Claas FH, Bemelman FJ, and Otten HG
- Subjects
- Adult, Female, Follow-Up Studies, Graft Rejection diagnosis, Graft Rejection etiology, Humans, Isoantibodies immunology, Kidney Failure, Chronic immunology, Kidney Failure, Chronic mortality, Kidney Failure, Chronic surgery, Living Donors statistics & numerical data, Male, Middle Aged, Postoperative Complications diagnosis, Postoperative Complications etiology, Prognosis, Retrospective Studies, Risk Factors, Autoantibodies immunology, Graft Rejection mortality, Graft Survival immunology, HLA Antigens immunology, Kidney Transplantation adverse effects, Postoperative Complications mortality, rho Guanine Nucleotide Dissociation Inhibitor beta immunology
- Abstract
The clinical significance of non-HLA antibodies on renal allograft survival is a matter of debate, due to differences in reported results and lack of large-scale studies incorporating analysis of multiple non-HLA antibodies simultaneously. We developed a multiplex non-HLA antibody assay against 14 proteins highly expressed in the kidney. In this study, the presence of pretransplant non-HLA antibodies was correlated to renal allograft survival in a nationwide cohort of 4770 recipients transplanted between 1995 and 2006. Autoantibodies against Rho GDP-dissociation inhibitor 2 (ARHGDIB) were significantly associated with graft loss in recipients transplanted with a deceased-donor kidney (N = 3276) but not in recipients of a living-donor kidney (N = 1496). At 10 years after deceased-donor transplantation, recipients with anti-ARHGDIB antibodies (94/3276 = 2.9%) had a 13% lower death-censored covariate-adjusted graft survival compared to the anti-ARHGDIB-negative (3182/3276 = 97.1%) population (hazard ratio 1.82; 95% confidence interval, 1.32-2.53; P = .0003). These antibodies occur independently from donor-specific anti-HLA antibodies (DSA) or other non-HLA antibodies investigated. No significant relations with graft loss were found for the other 13 non-HLA antibodies. We suggest that pretransplant risk assessment can be improved by measuring anti-ARHGDIB antibodies in all patients awaiting deceased-donor transplantation., (© 2019 The Authors. American Journal of Transplantation published by Wiley Periodicals, Inc. on behalf of The American Society of Transplantation and the American Society of Transplant Surgeons.)
- Published
- 2019
- Full Text
- View/download PDF
40. A paired kidney analysis on the impact of pre-transplant anti-HLA antibodies on graft survival.
- Author
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Michielsen LA, Wisse BW, Kamburova EG, Verhaar MC, Joosten I, Allebes WA, van der Meer A, Hilbrands LB, Baas MC, Spierings E, Hack CE, van Reekum FE, Bots ML, Drop ACAD, Plaisier L, Seelen MAJ, Sanders JF, Hepkema BG, Lambeck AJ, Bungener LB, Roozendaal C, Tilanus MGJ, Voorter CE, Wieten L, van Duijnhoven EM, Gelens M, Christiaans MHL, van Ittersum FJ, Nurmohamed SA, Lardy NM, Swelsen W, van der Pant KA, van der Weerd NC, Ten Berge IJM, Bemelman FJ, Hoitsma A, van der Boog PJM, de Fijter JW, Betjes MGH, Heidt S, Roelen DL, Claas FH, Otten HG, and van Zuilen AD
- Subjects
- Adult, Female, Histocompatibility Antigens Class I, Humans, Kidney Transplantation mortality, Male, Middle Aged, Netherlands, Risk, Tissue Donors, Young Adult, Graft Rejection immunology, Graft Survival immunology, HLA Antigens immunology, Isoantibodies blood
- Abstract
Background: Pre-transplant donor-specific anti-human leucocyte antigen (HLA) antibodies (DSAs) are associated with impaired kidney graft survival while the clinical relevance of non-donor-specific anti-HLA antibodies (nDSAs) is more controversial. The aim of the present paired kidney graft study was to compare the clinical relevance of DSAs and nDSAs., Methods: To eliminate donor and era-dependent factors, a post hoc paired kidney graft analysis was performed as part of a Dutch multicentre study evaluating all transplantations between 1995 and 2005 with available pre-transplant serum samples. Anti-HLA antibodies were detected with a Luminex single-antigen bead assay., Results: Among 3237 deceased donor transplantations, we identified 115 recipient pairs receiving a kidney from the same donor with one recipient being DSA positive and the other without anti-HLA antibodies. Patients with pre-transplant DSAs had a significantly lower 10-year death-censored graft survival (55% versus 82%, P=0.0001). We identified 192 pairs with one recipient as nDSA positive (against Class I and/or II) and the other without anti-HLA antibodies. For the patients with nDSAs against either Class I or II, graft survival did not significantly differ compared with patients without anti-HLA antibodies (74% versus 77%, P = 0.79). Only in patients with both nDSAs Class I and II was there a trend towards a lower graft survival (58%, P = 0.06). Lastly, in a small group of 42 recipient pairs, 10-year graft survival in recipients with DSAs was 49% compared with 68% in recipients with nDSAs (P=0.11)., Conclusion: This paired kidney analysis confirms that the presence of pre-transplant DSAs in deceased donor transplantations is a risk marker for graft loss, whereas nDSAs in general are not associated with a lower graft survival. Subgroup analysis indicated that only in broadly sensitized patients with nDSAs against Class I and II, nDSAs may be a risk marker for graft loss in the long term., (© The Author(s) 2018. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.)
- Published
- 2019
- Full Text
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41. Toward a Sensible Single-antigen Bead Cutoff Based on Kidney Graft Survival.
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Wisse BW, Kamburova EG, Joosten I, Allebes WA, van der Meer A, Hilbrands LB, Baas MC, Spierings E, Hack CE, van Reekum FE, van Zuilen AD, Verhaar MC, Bots ML, Drop ACAD, Plaisier L, Seelen MAJ, Stephan Sanders J, Hepkema BG, Lambeck AJA, Bungener LB, Roozendaal C, Tilanus MGJ, Voorter CE, Wieten L, van Duijnhoven EM, Gelens MACJ, Christiaans MHL, van Ittersum FJ, Nurmohamed SA, Lardy NM, Swelsen W, van der Pant KAMI, van der Weerd NC, Ten Berge IJM, Bemelman FJ, Hoitsma AJ, van der Boog PJM, de Fijter JW, Betjes MGH, Heidt S, Roelen DL, Claas FH, and Otten HG
- Subjects
- Fluorescence, Humans, Isoantibodies blood, Tissue Donors, Graft Survival, HLA Antigens immunology, Kidney Transplantation
- Abstract
Background: There is no consensus in the literature on the interpretation of single-antigen bead positive for a specific HLA antibody., Methods: To inform the debate, we studied the relationship between various single-antigen bead positivity algorithms and the impact of resulting donor-specific HLA antibody (DSA) positivity on long-term kidney graft survival in 3237 deceased-donor transplants., Results: First, we showed that the interassay variability can be greatly reduced when working with signal-to-background ratios instead of absolute median fluorescence intensities (MFIs). Next, we determined pretransplant DSA using various MFI cutoffs, signal-to-background ratios, and combinations thereof. The impact of the various cutoffs was studied by comparing the graft survival between the DSA-positive and DSA-negative groups. We did not observe a strong impact of various cutoff levels on 10-year graft survival. A stronger relationship between the cutoff level and 1-year graft survival for DSA-positive transplants was found when using signal-to-background ratios, most pronounced for the bead of the same HLA locus with lowest MFI taken as background., Conclusions: With respect to pretransplant risk stratification, we propose a signal-to-background ratio-6 (using the bead of the same HLA-locus with lowest MFI as background) cutoff of 15 combined with an MFI cutoff of 500, resulting in 8% and 21% lower 1- and 10-year graft survivals, respectively, for 8% DSA-positive transplants.
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- 2019
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42. Pretransplant C3d-Fixing Donor-Specific Anti-HLA Antibodies Are Not Associated with Increased Risk for Kidney Graft Failure.
- Author
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Kamburova EG, Wisse BW, Joosten I, Allebes WA, van der Meer A, Hilbrands LB, Baas MC, Spierings E, Hack CE, van Reekum FE, van Zuilen AD, Verhaar MC, Bots ML, Drop ACAD, Plaisier L, Seelen MAJ, Sanders JS, Hepkema BG, Lambeck AJA, Bungener LB, Roozendaal C, Tilanus MGJ, Voorter CE, Wieten L, van Duijnhoven EM, Gelens MACJ, Christiaans MHL, van Ittersum FJ, Nurmohamed SA, Lardy NM, Swelsen W, van der Pant KAMI, van der Weerd NC, Ten Berge IJM, Bemelman FJ, Hoitsma AJ, van der Boog PJM, de Fijter JW, Betjes MGH, Heidt S, Roelen DL, Claas FH, and Otten HG
- Subjects
- Adult, Age Distribution, Antilymphocyte Serum immunology, Cohort Studies, Female, Follow-Up Studies, Graft Rejection epidemiology, Humans, Incidence, Kidney Transplantation methods, Male, Middle Aged, Preoperative Care methods, Retrospective Studies, Risk Assessment, Sex Distribution, Tissue Donors, Transplant Recipients statistics & numerical data, Transplantation Immunology, Antibodies, Anti-Idiotypic immunology, Complement C3d immunology, Graft Rejection immunology, HLA Antigens immunology, Kidney Transplantation adverse effects, Registries
- Abstract
Background Complement-fixing antibodies against donor HLA are considered a contraindication for kidney transplant. A modification of the IgG single-antigen bead (SAB) assay allows detection of anti-HLA antibodies that bind C3d. Because early humoral graft rejection is considered to be complement mediated, this SAB-based technique may provide a valuable tool in the pretransplant risk stratification of kidney transplant recipients. Methods Previously, we established that pretransplant donor-specific anti-HLA antibodies (DSAs) are associated with increased risk for long-term graft failure in complement-dependent cytotoxicity crossmatch-negative transplants. In this study, we further characterized the DSA-positive serum samples using the C3d SAB assay. Results Among 567 pretransplant DSA-positive serum samples, 97 (17%) contained at least one C3d-fixing DSA, whereas 470 (83%) had non-C3d-fixing DSA. At 10 years after transplant, patients with C3d-fixing antibodies had a death-censored, covariate-adjusted graft survival of 60%, whereas patients with non-C3d-fixing DSA had a graft survival of 64% (hazard ratio, 1.02; 95% confidence interval, 0.70 to 1.48 for C3d-fixing DSA compared with non-C3d-fixing DSA; P =0.93). Patients without DSA had a 10-year graft survival of 78%. Conclusions The C3d-fixing ability of pretransplant DSA is not associated with increased risk for graft failure., (Copyright © 2018 by the American Society of Nephrology.)
- Published
- 2018
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43. Distinct in vitro Complement Activation by Various Intravenous Iron Preparations.
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Hempel JC, Poppelaars F, Gaya da Costa M, Franssen CF, de Vlaam TP, Daha MR, Berger SP, Seelen MA, and Gaillard CA
- Subjects
- Administration, Intravenous, Anemia, Iron-Deficiency complications, Complement C1q drug effects, Complement C1q metabolism, Complement C3d drug effects, Complement C3d metabolism, Complement Membrane Attack Complex drug effects, Complement Membrane Attack Complex metabolism, Disaccharides pharmacology, Disaccharides therapeutic use, Ferric Compounds pharmacology, Ferric Compounds therapeutic use, Ferric Oxide, Saccharated, Ferrosoferric Oxide pharmacology, Ferrosoferric Oxide therapeutic use, Glucaric Acid pharmacology, Glucaric Acid therapeutic use, Hematinics therapeutic use, Humans, In Vitro Techniques, Iron Compounds therapeutic use, Iron-Dextran Complex pharmacology, Iron-Dextran Complex therapeutic use, Kidney Failure, Chronic complications, Maltose analogs & derivatives, Maltose pharmacology, Maltose therapeutic use, Mannose-Binding Lectin drug effects, Mannose-Binding Lectin metabolism, Properdin drug effects, Properdin metabolism, Renal Dialysis, Anemia, Iron-Deficiency drug therapy, Complement Activation drug effects, Hematinics pharmacology, Iron Compounds pharmacology, Kidney Failure, Chronic therapy
- Abstract
Background: Intravenous (IV) iron preparations are widely used in the treatment of anemia in patients undergoing hemodialysis (HD). All IV iron preparations carry a risk of causing hypersensitivity reactions. However, the pathophysiological mechanism is poorly understood. We hypothesize that a relevant number of these reactions are mediated by complement activation, resulting in a pseudo-anaphylactic clinical picture known as complement activation-related pseudo allergy (CARPA)., Methods: First, the in-vitro complement-activating capacity was determined for 5 commonly used IV iron preparations using functional complement assays for the 3 pathways. Additionally, the preparations were tested in an ex-vivo model using the whole blood of healthy volunteers and HD patients. Lastly, in-vivo complement activation was tested for one preparation in HD patients., Results: In the in-vitro assays, iron dextran, and ferric carboxymaltose caused complement activation, which was only possible under alternative pathway conditions. Iron sucrose may interact with complement proteins, but did not activate complement in-vitro. In the ex-vivo assay, iron dextran significantly induced complement activation in the blood of healthy volunteers and HD patients. Furthermore, in the ex-vivo assay, ferric carboxymaltose and iron sucrose only caused significant complement activation in the blood of HD patients. No in-vitro or ex-vivo complement activation was found for ferumoxytol and iron isomaltoside. IV iron therapy with ferric carboxymaltose in HD patients did not lead to significant in-vivo complement activation., Conclusion: This study provides evidence that iron dextran and ferric carboxymaltose have complement-activating capacities in-vitro, and hypersensitivity reactions to these drugs could be CARPA-mediated., (© 2016 The Author(s) Published by S. Karger AG, Basel.)
- Published
- 2017
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44. Uncovering of body mass index as a risk factor for poor long-term outcome after renal transplantation.
- Author
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Deetman PE, Sanders JS, Seelen MA, Gans RO, Navis G, and Bakker SJ
- Subjects
- Humans, Delayed Graft Function etiology, Kidney Transplantation adverse effects, Obesity complications
- Published
- 2015
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45. Novel insights in localization and expression levels of C5aR and C5L2 under native and post-transplant conditions in the kidney.
- Author
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van Werkhoven MB, Damman J, Daha MR, Krikke C, van Goor H, van Son WJ, Hillebrands JL, van Dijk MC, and Seelen MA
- Subjects
- Graft Rejection immunology, Graft Rejection pathology, Humans, Immunohistochemistry, Kidney pathology, Kidney Diseases immunology, Kidney Diseases pathology, Kidney Transplantation pathology, Kidney Tubular Necrosis, Acute immunology, Kidney Tubular Necrosis, Acute pathology, Kidney Tubules metabolism, Kidney Tubules pathology, Receptor, Anaphylatoxin C5a, Kidney immunology, Kidney Transplantation immunology, Receptors, Chemokine metabolism, Receptors, Complement metabolism
- Abstract
Aims: The complement system, and especially C5a, plays an important role in the pathophysiology of renal diseases and post-transplant renal injury. The two receptors for C5a are C5a receptor (C5aR) and C5a-like-receptor-2 (C5L2). Only renal C5aR expression has been reported, although exact localization and alterations in expression after transplantation are unknown., Materials and Results: Renal C5aR and C5L2 expression and localization were analyzed immunohistochemically. C5aR and C5L2 expression was analyzed in human kidney biopsies obtained from living donors and patients suffering from acute tubular necrosis, acute cellular and vascular rejection or IF/TA. C5aR was expressed in the thick ascending limb of Henle's loop and first part of the distal convoluted tubule (DCT). Under inflammatory conditions, C5aR was de novo expressed in proximal tubuli. C5L2 was expressed in the kidney and localized to DCT1, DCT2 and connecting tubule. Persistent distal tubular expression of both receptors was demonstrated after renal transplantation., Conclusions: This study shows distinct renal expression patterns for C5aR and C5L2. Our findings suggest a functional role for renal C5L2 rather than being a C5a decoy receptor. Future studies focusing on renal C5a-C5aR interaction should take differential C5aR and C5L2 expression into account, alongside abundant C5aR expression on infiltrating cells., (Copyright © 2012 Elsevier Ltd. All rights reserved.)
- Published
- 2013
- Full Text
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46. Role of complement in innate and autoimmunity.
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Seelen MA, Roos A, and Daha MR
- Subjects
- Animals, Humans, Kidney Diseases immunology, Kidney Diseases metabolism, Autoimmunity physiology, Complement System Proteins physiology, Immunity, Innate physiology
- Abstract
The complement system is a major driver of our innate immune response and plays an important role in defence against foreign pathogens. It is composed of a large number of proteins that are found in the circulation, in tissues and other body fluids in pro-enzymatic form. The many biologic activities of the complement system are uncovered following activation by three known pathways. Together with phagocytic cells the complement system is a powerful tool to defend the host against foreign attack. However the complement system, under certain conditions, can be unfavorable to the host namely in diseases such as IgA nephropathy, systemic lupus erythematosus and in diseases where minor changes have occurred in the integrity of tissue such as in ischemia reperfusion. This review describes the many faces of complement in the field of innate and acquired immunity and takes the reader on a journey of the role of complement in health and disease.
- Published
- 2005
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