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6. List of Contributors

Author

Babenko, N.A., primary, Beken, S., additional, Bernoud-Hubac, N., additional, Birgisdottir, B.E., additional, Butt, C.M., additional, Chen, T.C., additional, Daschner, A., additional, Erkkilä, A., additional, Fell, G.L., additional, Fernandes, L.C., additional, Genot, C., additional, Grung, B., additional, Gura, K.M., additional, Hansen, A.L., additional, Harris, M.A., additional, Harris, W.S., additional, Hintze, K., additional, Ismail, A., additional, Jaczynski, J., additional, Jahns, L., additional, Kabataş, E.U., additional, Khan, M.W., additional, Khan, S.A., additional, Kris-Etherton, P.M., additional, Lammi-Keefe, C.J., additional, Lands, B., additional, Lankinen, M., additional, Lara, J., additional, Lean, M., additional, Lewis, M.D., additional, McLennan, P.L., additional, Meynier, A., additional, Michalski, M-C., additional, Peoples, G.E., additional, Picklo, M.J., additional, Priyamvada, S., additional, Puder, M., additional, Ramón Bonache, R., additional, Rice, H.B., additional, Richter, C.K., additional, Salem, N., additional, Seelaender, M., additional, Simopoulos, A.P., additional, Skulas-Ray, A.C., additional, Steffen, B.T., additional, Steffen, L.M., additional, Tørris, C., additional, Tahergorabi, R., additional, Thorsdottir, I., additional, Ulven, S.M., additional, von Schacky, C., additional, Ward, R., additional, Yusufi, A.N.K., additional, Yusufi, F.N. Khan, additional, and Zheng, S., additional

Published
2016
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15. The Mechanical Stimulation of Myotubes Counteracts the Effects of Tumor-Derived Factors Through the Modulation of the Activin/Follistatin Ratio

Author

Baccam, A, Benoni-Sviercovich, A, Rocchi, M, Moresi, V, Seelaender, M, Li, Z, Adamo, S, Xue, Z, Coletti, D, Adaptation Biologique et Vieillissement = Biological Adaptation and Ageing (B2A), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Paris Seine (IBPS), and Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV.BBM.BP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, skeletal muscle atrophy, exercise, C26 colon carcinoma, FlexCell apparatus, mechanotransduction, myokines, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2019

21. 1-03 Role of Activin A in human cancer cachexia (ACTICA study)

Author

Baracos, Vickie, Muscaritoli, Maurizio, Aversa, Zaira, Rossi Fanelli, Filippo, Loumaye, A, de Barsy, M, Nachit, M, Frateur, L, Lause, P, Van Maanen, A, Thissen, JP, Awasthi, R, Gillis, C, Liberman, S, Stein, B, Charlebois, P, Carli, F, Ahmad, Sultan, Chiche, Dan, Reza Kazemi-Bajestani, Seyyed Mohammad, Becher, Harald, Venner, Peter, North, Scott, Vickie, Baracos, Li, Yi-Ping, Zhang, Guohua, Ma, Jennifer, Hall, Derek, Patel, Devang, Robinson, Samantha, Di Marco, Sergio, Gallouzi, Imed-Eddine, Sartori, Roberta, Penna, Fabio, Costelli, Paola, Sandri, Marco, Gregorevic, Paul, Toth, Michael J, Miller, Mark S, Callahan, Damien M, Couch, Marion E, Dittus, Kim, Sharma, Mridula, Argilés, Josep M, Bedard, N, Wiles, B, Jammoul, S, Miao, M, Wykes, L, Coyne, E, Hallauer, PL, Hastings, KEM, Stretch, C, Baracos, VE, Chevalier, S, Wing, SS, Marchildon, François, Lala, Neena, St-Louis, Catherine, Wiper-Bergeron, Nadine, Santos Silva, Kleiton Augusto, Dong, Jiangling, Tweardy, David J, Mitch, William E, Zhang, Liping, Hall, Derek T, Ma, Jennifer F, Griss, Takla, Jones, Russell G, Marco, Sergio Di, Marks, Daniel L, Rudnicki, Michael A, Laine, Aaron, Narayanan, Sriram, Choy, Hak, Girard, Luc, Gazdar, Adi, Minna, John, Infante, Rodney, Iyengar, Puneeth, Petruzzelli, Michele, Schweiger, Martina, Rincon, Mercedes, Robertson, Graham, Zechner, Rudolf, Wagner, Erwin F, Pin, Fabrizio, Costamagna, Domiziana, Camperi, Andrea, Sampaolesi, Maurilio, He, Wei, Talbert, Erin, Londhe, Priya, Bloomston, Mark, Croce, Carlo, Guttridge, Denis, Breit, Samuel N, Tsai, Vicky WW, Manandhar, Rakesh, Lin, Shu, Sainsbury, Amanda, Brown, David A, Ferrara, Michele, Reano, Simone, Angelino, Elia, Sabry, Omar, Filigheddu, Nicoletta, Graziani, Andrea, Tsoli, Maria, Allen, John, Taylor, Ryland, Scwheiger, Martina, Swarbrick, Michael M, Ehteda, Anahid, Miekle, Peter, Molloy, Mark, Waning, David L, Mohammad, Khalid S, Reiken, Steven, Xie, Wenjun, Marks, Andrew R, Guise, Theresa A, Moya, Rosita, Zhao, Chunfang, Davies, Joanna D, Carson, James, Everett Couch, Marion, Stecher, Michael, El Mouelhi, Mohamed, Tseng, Yu-Chou, Kulp, Samuel K, Lai, I-Lu, Hsu, En-Chi, He, Wei A, Frankhouser, David E, Yan, Pearlly S, Mo, Xiaokui, Lesinski, Gregory B, Marcucci, Guido, Guttridge, Denis C, Bekaii-Saab, Tanios, Chen, Ching-Shih, Haddad, AHI Al, Al-Azwani, EK, Mahamoud, Y, Safi, F, Salhat, H El, Malek, JA, Adrian, TE, Fearon, K, Temel, J, Currow, D, Gleich, L, Friend, J, Abernethy, A, Garcia, Jose M, Dubé, A, Patoine, D, Lemire, BB, Thériault, M-E, Ribeiro, F, Debigaré, R, Maltais, F, Smuder, Ashley J, Min, Kisuk, Kwon, Oh-Sung, Wiggs, Michael P, Sollanenk, Kurt J, Christou, Demetra D, Yoo, Jeung-Ki, Hwang, Moon-Hyon, Szeto, Hazel H, Kavazis, Andreas N, Powers, Scott K, Kroenke, Candyce H, Meyerhardt, Jeffrey A, Kwan, Marilyn L, Prado, Carla, Xiao, Jingjie, Weltzien, Erin, Castillo, Adrienne, Caan, Bette J, Guan, Chen, Giles, Kaitlin, Wing, Simon, Mazurak, Vera, Jagoe, R Thomas, Wiles, Benjamin, Miao, Miao, Coyne, Erin, Larose, Louise, Cybulsky, Andrey V, Wing, Simon S, Marino, Francesco Elia, Risbridger, Gail, Gold, Elspeth, Segatto, Marco, Fittipaldi, Raffaella, Caretti, Giuseppina, Lee, Hwabin, Fu, Dechen, Dwarkasing, JT, Boekschoten, MV, Argilès, JM, van Dijk, M, Busquets, S, Penna, F, Toledo, M, Laviano, A, Witkamp, RF, van Norren, K, Bédard, Nathalie, Plourde, Marie, Chevalier, Stéphanie, Lala-Tabbert, Neena, Marchildon, Francois, Torabi, S, Glare, P, Plodkowski, A, Margaron, Yoran, Fernandes, Mathieu, Morales, Delphine, Poydenot, Pauline, Menager, Pauline, Fuchs, Alexandra, Degot, Sébastien, Calore, Federica, Canella, Alessandro, Croce, Carlo M, Srinivasan, Kalayarasan, Pulliparracharuvil, Suprabha, Meyer, Jeffrey, Scherer, Philipp E, Kambadur, Ravi, Martinelli, Giulia B, Talamini, Laura, Previdi, Sara, Piccirillo, Rosanna, Jafri, Syed H, Previgliano, Carlos, Khandelwal, Keerti, Shi, Runhua, Mills, Glenn, Amato, Robert, Coats, Valérie, Ribeiro, Fernanda, Tremblay, Lise, Lacasse, Yves, Maltais, François, Saey, Didier, AL Vigano, Antonio, Ciutto, Lorella, Tomasso, Jonathan Di, Kilgour, Robert D, Morais, José A, Borod, Manuel, Almasud, A, Giles, K, Baracos, V, Guan, L, Mazurak, V, Khanuja, Jasleen, Gresham, Gillian, Osipov, Arsen, Tan, Carlyn-Rose, Tuli, Richard, Hendifar, Andrew, Narasimhan, Ashok, Greiner, Russell, Yasui, Yutaka, Bathe, Oliver, Fearon, Kenneth, Damaraju, Sambasivarao, Banh, Taylor, Kliewer, Kara, Hsiao, Yung-Hsuan, Belury, Martha A, Caan, Bette, Quesenberry, Charles, Kwan, Marilyn, Prado, Carla MM, Baracos, Vickie E, Birdsell, Laura, Stuyckens, Kim, Park, Youn Choi, Parekh, Trilok, Sawyer, Michael B, Wu, C, Fernandez, SA, Criswell, T, Chidiac, T, Guttridge, D, Villalona-Calero, M, Bekaii-Saab, T, Khan, Sarah, ALVigano, Antonio, Matos-Neto, EM, Figuerêdo, RG, Camargo, RG, Lima, JDCC, Alves, MJ, Riccardi, D, Alcantara, PS, Pinhata, J, Maximiano, L, Seelaender, M, Lamarche, Émilie, Au, Ernie D, Desai, Aditya P, Koniaris, Leonidas G, Zimmers, Teresa A, Manring, Heather, Weisleder, Noah, Okamura, Heidi, Frankhouser, David, Yan, Pearlly, Tomasso, Jonathan di, Fabbro, Egidio G Del, Davis, Mellar P, Fearon, Kenneth CH, Jatoi, Aminah A, Vigano, Antonio, Putman, Ted, Kezhuo, Zhang, Sladek, Robert, Enjiu, LM, Gomes, SP, Matos-Neto, E, Rossi-Fanneli, F, Seelaender, MC, Ebadi, Maryam, Mazurak, Vera C, Bhatia, Nikita, Padliya, Neerav D, Stadler, Volker, Dariani, Maghsoud, Hariri, Robert J, Parker, Valorie A, Matthews, Ryan R, Bonetto, Andrea, Puppa, Melissa, Kang, Kyung Shin, Mohammed, Khalid S, Robling, Alexander G, Toledo, Míriam, Oliva, Francesc, Luque, Melania, Betancourt, Angelica, Marmonti, Enrica, López-Soriano, Francisco J, Busquets, Sílvia, Theal, Rebecca, Jiang, Heng, Sanchez, Anthony, Hussain, Sabah N, Serpe, R, Madeddu, C, Gudiño, V, Gabba, S, Antoni, G, Macciò, A, and Banni, S

Subjects
Abstracts
Published
2015

23. Neurolysin knockout mice generation and initial phenotype characterization

Author

Cavalcanti, D.M.L.P., Castro, L.M., Rosa Neto, J.C., Seelaender, M., Neves, R.X., Oliveira, V., Forti, F.L., Iwai, L.K., Gozzo, F.C., Todiras, M., Schadock, I., Barros, C.C., Bader, M., and Ferro, E.S.

Subjects
Cardiovascular and Metabolic Diseases
Abstract

The oligopeptidase neurolysin (EC 3.4.24.16; Nln) was first identified in rat brain synaptic membranes and shown to ubiquitously participate in the catabolism of bioactive peptides such as neurotensin and bradykinin. Recently, it was suggested that Nln reduction could improve insulin sensitivity. Here, we have shown that Nln knockout mice (KO) have increased glucose tolerance, insulin sensitivity and gluconeogenesis. KO mice have increased liver mRNA for several genes related to gluconeogenesis. Isotopic label semi-quantitative peptidomic analysis suggests increase in specific intracellular peptides in gastrocnemius and epididymal adipose tissue, which likely is involved with the increased glucose tolerance and insulin sensitivity in the KO mice. These results suggest the exciting new possibility that Nln is a key enzyme for energy metabolism and could be a novel therapeutic target to improve glucose uptake and insulin sensitivity.

Published
2014

24. FRI0029 Human CD40l Deficiency Dysregulates The Macrophage Transcriptome Causing Functional Defects That Are Improved by Exogenous IFN-Gamma

Author

Marques, O.C., primary, Schimke Marques, L.F., additional, Khan, T.A., additional, Pinheiro Amaral, E., additional, Barbosa Bomfim, C.C., additional, Reis Junior, O., additional, Correia Lima, J.D.C., additional, Worm Weber, C., additional, Fernandes Ferreira, J., additional, Scancetti Tavares, F., additional, D'Imperio Lima, M.R., additional, Seelaender, M., additional, Garcia Calich, V.L., additional, Marzagão Barbuto, J.A., additional, Tavares Costa-Carvalho, B., additional, Riemekasten, G., additional, Torgerson, T., additional, Ochs, H.D., additional, and Condino-Neto, A., additional

Published
2016
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27. Inflammation in Cachexia

Author

Seelaender, M., primary, Laviano, A., additional, Busquets, S., additional, Püschel, G. P., additional, Margaria, T., additional, and Batista, M. L., additional

Published
2015
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30. AKI - Experimental

Author

Kaynar, K., primary, Kaynar, K., additional, Ersoz, S., additional, Aliyazioglu, R., additional, Uzun, A., additional, Ulusoy, S., additional, Al, S., additional, Ozkan, G., additional, Cansiz, M., additional, Bertocchio, J.-P., additional, Lancon, J., additional, El Moghrabi, S., additional, Galmiche, G., additional, Duong Van Huyen, J.-P., additional, Rieu, P., additional, Jaisser, F., additional, Albertoni, G., additional, Andrade, S., additional, Barreto, J. A., additional, Borges, F., additional, Schor, N., additional, Ho, W.-Y., additional, Chen, S.-H., additional, Tseng, C.-J., additional, Bienholz, A., additional, Feldkamp, T., additional, Weinberg, J. M., additional, Suller Garcia, J., additional, Naves, M., additional, Aparecida Reis, L., additional, Simoes, M. d. J., additional, S Almeida, W., additional, Moreau Longo, V., additional, Segreto, H. R. C., additional, Ghoneim, A., additional, Elkholy, A., additional, Medhat Abbas, T., additional, El Hadeedy, M., additional, Elhusseini, F., additional, Elessawey, B., additional, Eltanaihy, E., additional, Lotfy, A., additional, Eldesoky, S., additional, Sheashaa, H., additional, Sobh, M., additional, Minning, D. M., additional, Warnock, D., additional, Mohamed, A. S., additional, Wirthlin, J. B., additional, Chintalacharuvu, S. R., additional, Boone, L., additional, Brenner, R. M., additional, Santina Christo, J., additional, Dos Santos Passos, C., additional, Rene de Alencar, D., additional, De Braganca, A. C., additional, Canale, D., additional, Goncalves, J. G., additional, Brandao, T. P. B., additional, Shimizu, M. H. M., additional, Volpini, R. A., additional, Seguro, A. C., additional, Andrade, L., additional, Lee, J.-W., additional, Kim, H. K., additional, Cho, W. Y., additional, Jo, S.-K., additional, Cho, E., additional, Hocherl, K., additional, Schmidt, C., additional, Mulay, S. R., additional, Kulkarni, O. P., additional, Rupanagudi, K. V., additional, Migliorini, A., additional, Liapis, H., additional, Anders, H.-J., additional, Pevzner, I., additional, Chupyrkina, A., additional, Plotnikov, E., additional, Zorov, D., additional, Lopez-Novoa, J.-M., additional, Eleno, N., additional, Perez-Barriocanal, F., additional, Arevalo, M., additional, Docherty, N., additional, Castellano, G., additional, Divella, C., additional, Loverre, A., additional, Stasi, A., additional, Curci, C., additional, Rossini, M., additional, Ditonno, P., additional, Battaglia, M., additional, Daha, M. R., additional, Van Kooten, C., additional, Gesualdo, L., additional, Schena, F. P., additional, Grandaliano, G., additional, Tsuda, H., additional, Kawada, N., additional, Iwatani, H., additional, Moriyama, T., additional, Takahara, S., additional, Rakugi, H., additional, Isaka, Y., additional, Schley, G., additional, Kalucka, J., additional, Klanke, B., additional, Jantsch, J., additional, Olbrich, S., additional, Baumgartl, J., additional, Amann, K., additional, Eckardt, K.-U., additional, Weidemann, A., additional, Dolgolikova, A., additional, Pilotovich, V., additional, Ivanchik, G., additional, Shved, I., additional, Banki, N. F., additional, Antal, Z., additional, Hosszu, A., additional, Koszegi, S., additional, Vannay, A., additional, Wagner, L., additional, Prokai, A., additional, Muller, V., additional, Szabo, A. J., additional, Fekete, A., additional, Farrag, S., additional, Abulasrar, S., additional, Salama, , M., additional, Amin, M., additional, Ali, A., additional, Rubera, I., additional, Duranton, C., additional, Cougnon, M., additional, Melis, N., additional, Tauc, M., additional, Jankauskas, S., additional, Morosanova, M., additional, Pulkina, N., additional, Zorova, L., additional, Shin, Y. T., additional, Kim, S. S., additional, Chang, Y. K., additional, Choi, D. E., additional, Na, K.-R., additional, Lee, K. W., additional, Choi, J.-Y., additional, Jin, D.-C., additional, Cha, J.-H., additional, Schneider, R., additional, Betz, B., additional, Meusel, M., additional, Held, C., additional, Wanner, C., additional, Gekle, M., additional, Sauvant, C., additional, Pisani, A., additional, Rossano, R., additional, Mancini, A., additional, Arfian, N., additional, Yagi, K., additional, Nakayama, K., additional, Ali, H., additional, Mayasari, D. S., additional, Purnomo, E., additional, Emoto, N., additional, Efrati, S., additional, Berman, S., additional, Abu Hamad, R., additional, Weissgarten, J., additional, Scherbaum, C. R., additional, Allam, R., additional, Lichtnekert, J., additional, Darisipudi, M. N., additional, Hagele, H., additional, Hohenstein, B., additional, Hugo, C., additional, Schaefer, L., additional, Corsi, C., additional, Ferramosca, E., additional, Grandi, E., additional, Pisoni, L., additional, Rivolta, I., additional, Dalpozzo, B., additional, Hoxha, E., additional, Severi, S., additional, Santoro, A., additional, Laurent, M., additional, Cedric, R., additional, Dominique, C., additional, Sophie, V., additional, Nochy, D., additional, Loic, G., additional, Patrice, C., additional, Chantal, J., additional, Marie-Christine, V., additional, Alexandre, H., additional, Eric, R., additional, Cantaluppi, V., additional, Medica, D., additional, Quercia, A. D., additional, Figliolini, F., additional, Dellepiane, S., additional, Randone, O., additional, Segoloni, G. P., additional, Camussi, G., additional, Ahn, B.-H., additional, Kim, S. H., additional, Yasue Saito Miyagi, M., additional, Camara, N., additional, Cerqueira Leite Seelaender, M., additional, Maceratesi Enjiu, L., additional, Estler Rocha Guilherme, P., additional, Pisciottano, M., additional, Hiyane, M., additional, Yuri Hayashida, C., additional, De Andrade Oliveira, V., additional, Olsen Saraiva Camara, N., additional, Tami Amano, M., additional, Sancho-Martinez, S. M., additional, Sanchez-Juanes, F., additional, Vicente, L., additional, Gonzalez-Buitrago, J. M., additional, Morales, A. I., additional, Lopez-Novoa, J. M., additional, Lopez-Hernandez, F. J., additional, Chen, J.-S., additional, Chang, L.-C., additional, Chen, C.-C., additional, Park, M. Y., additional, Choi, S. J., additional, Kim, J. G., additional, Hwang, S. D., additional, Vicente-Vicente, L., additional, Ferreira, L., additional, Prieto, M., additional, Garcia-Sanchez, O., additional, Sevilla, M. A., additional, Lopez-Novoa, F. J., additional, Christoph, K., additional, Kuper, C., additional, Maria-Luisa, F., additional, Franz-Xaver, B., additional, Neuhofer, W., additional, Vervaet, B., additional, Le Clef, N., additional, Verhulst, A., additional, D'haese, P., additional, Tanaka, T., additional, Yamaguchi, J., additional, Eto, N., additional, Kojima, I., additional, Fujita, T., additional, Nangaku, M., additional, Wystrychowski, A., additional, Wystrychowski, G., additional, Obuchowicz, E., additional, Grzeszczak, W., additional, Wiecek, A., additional, Esposito, C., additional, Torreggiani, M., additional, Castoldi, F., additional, Migotto, C., additional, Serpieri, N., additional, Grosjean, F., additional, Manini, A., additional, Pertile, E., additional, and Dal Canton, A., additional

Published
2012
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46. Exercise Training Decreases Adipose Tissue Inflammation in Cachectic Rats.

Author

Lira, F. S., Yamashita, A. S., Rosa, J. C., Koyama, C. H., Caperuto, E. C., Batista, Jr, M. L., and Seelaender, M. C. L.

Subjects
ADIPOSE tissues, CACHEXIA, CYTOKINES, RATS, LABORATORY rats
Abstract

Bearing in mind that cancer cachexia is associated with chronic systemic inflammation and that endurance training has been adopted as a nonpharmacological anti-inflammatory strategy, we examined the effect of 8 weeks of moderate intensity exercise upon the balance of anti- and pro-inflammatory cytokines in 2 diff erent depots of white adipose tissue in cachectic tumour-bearing (Walker-256 carcinosarcoma) rats. Animals were assigned to a sedentary control (SC), sedentary tumour-bearing (ST), sedentary pair-fed (SPF) or exercise control (EC), exercise tumour-bearing (ET), and exercise pair-fed (EPF) group. Trained rats ran on a treadmill (60 % VO2 max) 60 min/day, 5 days/week, for 8 weeks. The retroperitoneal (RPAT) and mesenteric (MEAT) adipose pads were excised and the mRNA (RT-PCR) and protein (ELISA) expression of IL-1β, IL-6, TNF-α, and IL-10 were evaluated. The number of infiltrating monocytes in the adipose tissue was increased in cachectic rats. TNF-α mRNA in MEAT was increased in the cachectic animals (p < 0.05) in relation to SC. RPAT protein expression of all studied cytokines was increased in cachectic animals in relation to SC and SPF (p < 0.05). In this pad, IL-10/TNF-α ratio was reduced in the cachectic animals in comparison with SC (p < 0.05) indicating inflammation. Exercise training improved IL-10/TNF-α ratio and induced a reduction of the infiltrating monocytes both in MEAT and RPAT (p < 0.05), when compared with ST. We conclude that cachexia is associated with inflammation of white adipose tissue and that exercise training prevents this effect in the MEAT, and partially in RPAT. [ABSTRACT FROM AUTHOR]

Published
2012
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48. The effect of Walker-256 tumour development upon Kupffer cell metabolism

Author

Rosa, L. F. B. P. Costa, Kazantzis, M., and Seelaender, M. C. L.

Abstract

The liver plays a central role in the establishment and maintenance of the cachectic state in rats bearing extra-hepatic tumours. Kupffer cells, which as macrophages, show a strong relationship between metabolism and function could be involved in the alterations observed in the disruption of many functions of the organ as a whole. To assess whether the metabolic/functional pattern of Kupffer cells was altered by cachexia we have investigated the utilization of glucose, glutamine and palmitate by the cells from tumour-bearing and control rats. We have found an enhanced utilization of the three substrates by the cells from tumour-bearing rats as compared with controls, which was related to greater energy production through the Krebs cycle and enhanced production of precursors for the synthesis of the many substances the cells secrete when activated. The use of palmitate as substrate was also augmented in these cells, in the opposition to the observation in stimulated peritoneal macrophages. The availability of palmitate however, was not associated with a reduction of glucose or glutamine consumption. The cycle of interconversion, free fatty acids/triacyglycerol in Kupffer cells from tumour-bearing rats was also found to be increased, as was hydrogen peroxide production. Taken together the results suggest an increased utilization of substrates for both energy production and for synthetic processes (e.g. NADPH for hydrogen peroxide production). © 1998 John Wiley & Sons, Ltd.

Published
1998
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