Search

Your search keyword '"Seegers J"' showing total 212 results
Start Over Author "Seegers J"
212 results on '"Seegers J"'

2. Cost Effectiveness of Endovascular Revascularisation vs. Exercise Therapy for Intermittent Claudication Due to Iliac Artery Obstruction

Author

Legemate, D.A., Idu, M.M., Balm, R., Reekers, J.A., van Lienden, K.P., van Delden, O.M., Zijlstra, E.J., Conijn, A.P., Dijkgraaf, M.G.W., Engelbert, R.H., De Nie, A.J., Schreve, M.A., Kropman, R.H.J., Wille, J., De Vries, J.P.M., van de Pavoort, H.D.W.M., van de Mortel, R.H.W., van den Heuvel, D.A.F., van Strijen, M.J.L., van Leersum, M., Vos, J.A., Nio, D., Rijbroek, A., Vermeulen, E.G.J., Akkersdijk, G.J.M., van de Elst, A., Truijers, M., van Kelckhoven, B.J., Leijdekkers, V.J., Vahl, A.C., Blomjous, J.G.A.M., Poyck, P.P.C., Van der Vliet, J.A., van der Jagt, M., Klemm, P.L., Willems, M.C.M., Huisman, L.C., Lensvelt, M.M.A., de Bruine, H., Mallant, M.P.J.H., Smeets, L., van Sterkenburg, S.M.M., Veendrick, P.B., van Werkum, M.H., Elsman, B.H.P., van der Hem, L.G., van Tongeren, R.B.M., Klok, C.F.M., Hellings, W.E., Wiersema, A.M., van den Broek, T.A.A., Vos, G.A., Teijink, J.A.W., van Sambeek, M.R.H.M., Keller, B.P.J.A., Glade, G.J., Breek, J.C., Gravendeel, J., Oosterhof-Berktas, R., Koedam, N.A., Hollander, E.J.F., Scharn, D.M., Lemson, M.S., Seegers, J., Krol, R.M., Blankensteijn, J.D., Hoksbergen, A.W.J., van Reijen, Nick S., van Dieren, Susan, Frans, Franceline A., Reekers, Jim A., Metz, Roderik, Buscher, Hessel C.J.L., and Koelemay, Mark J.W.

Published
2022
Full Text
View/download PDF

3. Editor's Choice – Randomised Clinical Trial of Supervised Exercise Therapy vs. Endovascular Revascularisation for Intermittent Claudication Caused by Iliac Artery Obstruction: The SUPER study

Author

Dijkgraaf, M.G.W., de Haan, R.J., Balm, R., Idu, M.M., Blankensteijn, J.D., Hoksbergen, A.W., Conijn, A.P., Met, R., Legemate, D.A., Bipat, S., van Lienden, K.P., van Delden, O.M., Zijlstra, E.J., Lely, R., Engelbert, R.H.H., van Egmond, M.A., Poelgeest, A., Geleijn, E., de Nie, A.J., Schreve, M.A., Kamphuis, A., Kropman, R.H.J., Wille, J., de Vries, J.P.M.M., van de Mortel, R.H., van de Pavoord, H.D., van den Heuvel, D.A., van Leersum, M., van Strijen, M.J., Vos, J.A., Nio, D., Rijbroek, A., Akkersdijk, G.J.M., Metz, R., van Kelckhoven, B.J., van de Rest, H.J., Leijdekkers, V.J., Vahl, A.C., van Nieuwenhuizen, R.C., Blomjous, J.G., Montauban van Swijndregt, A.D., Poyck, P.P.C., van der Jagt, M., van der Vliet, J.A., Schultze Kool, L.J., Klemm, P.L., Slis, H.W., Willems, M.C.M., Huisman, L.C., de Bruine, J.H.D., Mallant, M.J., Smeets, L., van Sterkenburg, S.M., Reijnen, M.M., Veendrick, P.B., van Werkum, M.H., van Ostayen, J.A., Elsman, B.H.P., van der Hem, L.G., van Tongeren, R.B.M., Klok, C.F.M., Hellings, W.E., Aarts, J.C., Wiersema, A.M., van den Broek, T.A., Moolhuijzen, A., Teijink, J.A., van Sambeek, M.R., Keller, B.P., Vos, G.A., Breek†, J.C., Gravendeel, J., Oosterhof-Berktas, R., Koedam, N.A., Hollander, E.J., Pels Rijcken, T., van der Voort, S.S., Honing, B., Scharn, D.M., Lemson, M.S., Seegers, J., Krol, R.M., Buskens, C.J., Zeebregts, C.J., de Bie, R.A., van Overhagen, H., Koelemay, Mark J.W., van Reijen, Nick S., van Dieren, Susan, Frans, Franceline A., Vermeulen, Erik J.G., Buscher, Hessel C.J.L., and Reekers, Jim A.

Published
2022
Full Text
View/download PDF

8. Randomised Clinical Trial of Supervised Exercise Therapy vs Endovascular Revascularisation for Intermittent Claudication Caused by Iliac Artery Obstruction: The SUPER study

Author

Koelemay, M.J.W., primary, van Reijen, N.S., additional, van Dieren, S., additional, Frans, F.A., additional, Vermeulen, E.J.G., additional, Buscher, H.C.J.L., additional, Reekers, J.A., additional, Dijkgraaf, M.G.W., additional, de Haan, R.J., additional, Balm, R., additional, Idu, M.M., additional, Blankensteijn, J.D., additional, Hoksbergen, A.W., additional, Conijn, A.P., additional, Met, R., additional, Legemate, D.A., additional, Bipat, S., additional, van Lienden, K.P., additional, van Delden, O.M., additional, Zijlstra, E.J., additional, Lely, R., additional, Engelbert, R.H.H., additional, van Egmond, M.A., additional, Poelgeest, A., additional, Geleijn, E., additional, de Nie, A.J., additional, Schreve, M.A., additional, Kamphuis, A., additional, Kropman, R.H.J., additional, Wille, J., additional, de Vries, J.P.M.M., additional, van de Mortel, R.H., additional, van de Pavoord, H.D., additional, van den Heuvel, D.A., additional, van Leersum, M., additional, van Strijen, M.J., additional, Vos, J.A., additional, Nio, D., additional, Rijbroek, A., additional, Akkersdijk, G.J.M., additional, Metz, R., additional, van Kelckhoven, B.J., additional, van de Rest, H.J., additional, Leijdekkers, V.J., additional, Vahl, A.C., additional, van Nieuwenhuizen, R.C., additional, Blomjous, J.G., additional, Montauban van Swijndregt, A.D., additional, Poyck, P.P.C., additional, van der Jagt, M., additional, van der Vliet, J.A., additional, Schultze Kool, L.J., additional, Klemm, P.L., additional, Slis, H.W., additional, Willems, M.C.M., additional, Huisman, L.C., additional, de Bruine, J.H.D., additional, Mallant, M.J., additional, Smeets, L., additional, van Sterkenburg, S.M., additional, Reijnen, M.M., additional, Veendrick, P.B., additional, van Werkum, M.H., additional, van Ostayen, J.A., additional, Elsman, B.H.P., additional, van der Hem, L.G., additional, van Tongeren, R.B.M., additional, Klok, C.F.M., additional, Hellings, W.E., additional, Aarts, J.C., additional, Wiersema, A.M., additional, van den Broek, T.A., additional, Moolhuijzen, A., additional, Teijink, J.A., additional, van Sambeek, M.R., additional, Keller, B.P., additional, Vos, G.A., additional, Breek†, J.C., additional, Gravendeel, J., additional, Oosterhof-Berktas, R., additional, Koedam, N.A., additional, Hollander, E.J., additional, Pels Rijcken, T., additional, van der Voort, S.S., additional, Honing, B., additional, Scharn, D.M., additional, Lemson, M.S., additional, Seegers, J., additional, and Krol, R.M., additional

Published
2022
Full Text
View/download PDF

9. Cost Effectiveness of Endovascular Revascularisation vs. Exercise Therapy for Intermittent Claudication Due to Iliac Artery Obstruction

Author

van Reijen, Nick S., primary, van Dieren, Susan, additional, Frans, Franceline A., additional, Reekers, Jim A., additional, Metz, Roderik, additional, Buscher, Hessel C.J.L., additional, Koelemay, Mark J.W., additional, Legemate, D.A., additional, Idu, M.M., additional, Balm, R., additional, Reekers, J.A., additional, van Lienden, K.P., additional, van Delden, O.M., additional, Zijlstra, E.J., additional, Conijn, A.P., additional, Dijkgraaf, M.G.W., additional, Engelbert, R.H., additional, De Nie, A.J., additional, Schreve, M.A., additional, Kropman, R.H.J., additional, Wille, J., additional, De Vries, J.P.M., additional, van de Pavoort, H.D.W.M., additional, van de Mortel, R.H.W., additional, van den Heuvel, D.A.F., additional, van Strijen, M.J.L., additional, van Leersum, M., additional, Vos, J.A., additional, Nio, D., additional, Rijbroek, A., additional, Vermeulen, E.G.J., additional, Akkersdijk, G.J.M., additional, van de Elst, A., additional, Truijers, M., additional, van Kelckhoven, B.J., additional, Leijdekkers, V.J., additional, Vahl, A.C., additional, Blomjous, J.G.A.M., additional, Poyck, P.P.C., additional, Van der Vliet, J.A., additional, van der Jagt, M., additional, Klemm, P.L., additional, Willems, M.C.M., additional, Huisman, L.C., additional, Lensvelt, M.M.A., additional, de Bruine, H., additional, Mallant, M.P.J.H., additional, Smeets, L., additional, van Sterkenburg, S.M.M., additional, Veendrick, P.B., additional, van Werkum, M.H., additional, Elsman, B.H.P., additional, van der Hem, L.G., additional, van Tongeren, R.B.M., additional, Klok, C.F.M., additional, Hellings, W.E., additional, Wiersema, A.M., additional, van den Broek, T.A.A., additional, Vos, G.A., additional, Teijink, J.A.W., additional, van Sambeek, M.R.H.M., additional, Keller, B.P.J.A., additional, Glade, G.J., additional, Breek, J.C., additional, Gravendeel, J., additional, Oosterhof-Berktas, R., additional, Koedam, N.A., additional, Hollander, E.J.F., additional, Scharn, D.M., additional, Lemson, M.S., additional, Seegers, J., additional, Krol, R.M., additional, Blankensteijn, J.D., additional, and Hoksbergen, A.W.J., additional

Published
2022
Full Text
View/download PDF

10. Editor's Choice – Randomised Clinical Trial of Supervised Exercise Therapy vs. Endovascular Revascularisation for Intermittent Claudication Caused by Iliac Artery Obstruction: The SUPER study

Author

Koelemay, Mark J.W., primary, van Reijen, Nick S., additional, van Dieren, Susan, additional, Frans, Franceline A., additional, Vermeulen, Erik J.G., additional, Buscher, Hessel C.J.L., additional, Reekers, Jim A., additional, Dijkgraaf, M.G.W., additional, de Haan, R.J., additional, Balm, R., additional, Idu, M.M., additional, Blankensteijn, J.D., additional, Hoksbergen, A.W., additional, Conijn, A.P., additional, Met, R., additional, Legemate, D.A., additional, Bipat, S., additional, van Lienden, K.P., additional, van Delden, O.M., additional, Zijlstra, E.J., additional, Lely, R., additional, Engelbert, R.H.H., additional, van Egmond, M.A., additional, Poelgeest, A., additional, Geleijn, E., additional, de Nie, A.J., additional, Schreve, M.A., additional, Kamphuis, A., additional, Kropman, R.H.J., additional, Wille, J., additional, de Vries, J.P.M.M., additional, van de Mortel, R.H., additional, van de Pavoord, H.D., additional, van den Heuvel, D.A., additional, van Leersum, M., additional, van Strijen, M.J., additional, Vos, J.A., additional, Nio, D., additional, Rijbroek, A., additional, Akkersdijk, G.J.M., additional, Metz, R., additional, van Kelckhoven, B.J., additional, van de Rest, H.J., additional, Leijdekkers, V.J., additional, Vahl, A.C., additional, van Nieuwenhuizen, R.C., additional, Blomjous, J.G., additional, Montauban van Swijndregt, A.D., additional, Poyck, P.P.C., additional, van der Jagt, M., additional, van der Vliet, J.A., additional, Schultze Kool, L.J., additional, Klemm, P.L., additional, Slis, H.W., additional, Willems, M.C.M., additional, Huisman, L.C., additional, de Bruine, J.H.D., additional, Mallant, M.J., additional, Smeets, L., additional, van Sterkenburg, S.M., additional, Reijnen, M.M., additional, Veendrick, P.B., additional, van Werkum, M.H., additional, van Ostayen, J.A., additional, Elsman, B.H.P., additional, van der Hem, L.G., additional, van Tongeren, R.B.M., additional, Klok, C.F.M., additional, Hellings, W.E., additional, Aarts, J.C., additional, Wiersema, A.M., additional, van den Broek, T.A., additional, Moolhuijzen, A., additional, Teijink, J.A., additional, van Sambeek, M.R., additional, Keller, B.P., additional, Vos, G.A., additional, Breek†, J.C., additional, Gravendeel, J., additional, Oosterhof-Berktas, R., additional, Koedam, N.A., additional, Hollander, E.J., additional, Pels Rijcken, T., additional, van der Voort, S.S., additional, Honing, B., additional, Scharn, D.M., additional, Lemson, M.S., additional, Seegers, J., additional, Krol, R.M., additional, Buskens, C.J., additional, Zeebregts, C.J., additional, de Bie, R.A., additional, and van Overhagen, H., additional

Published
2022
Full Text
View/download PDF

11. Interpreting Language: An Essential of Understanding.

Author

National Conference on Research in English., National Council of Teachers of English, Urbana, IL., and Seegers, J. Conrad

Abstract

This monograph points out the difficulties in language development of which teachers should be aware, suggests some methods through which children may be helped to overcome comprehension problems, and presents bibliographies helpful for persons who wish to undertake further reading. Chapters include "Some Possible Origins of the Prevalence of Verbalism," which defines verbalism and discusses the symbolic nature of language; "Reading and Understanding," which presents basic facts relating to understanding in reading, examines sources of difficulty in acquiring meaning, and suggests several necessary conditions for efficient teaching of reading; "How the Curriculum May Contribute to Understanding," which stresses the importance of first-hand experience in learning, presents studies on the significance of experience, and suggests approaches toward an experience-centered curriculum; and "The Development of Thinking and of Concepts," which stresses developing sensitivity toward word meanings and presents research acquainting teachers with the difficulties children encounter while acquiring language. Each chapter contains a bibliography. (RB)

Published
1951

24. Rationale and design of the EU-CERT-ICD prospective study: comparative effectiveness of prophylactic ICD implantation

Author

Zabel, Markus, Sticherling, Christian, Willems, Rik, Lubinski, Andrzej, Bauer, Axel, Bergau, Leonard, Braunschweig, Frieder, Brugada, Josep, Brusich, Sandro, Conen, David, Cygankiewicz, Iwona, Flevari, Panagiota, Taborsky, Milos, Hansen, Jim, Hasenfuss, Gerd, Hatala, Robert, Huikuri, Heikki V, Iovev, Svetoslav, Kaeaeb, Stefan, Kaliska, Gabriela, Kasprzak, Jaroslaw D, Luethje, Lars, Malik, Marek, Novotny, Tomas, Pavlovic, Nikola, Schmidt, Georg, Shalganov, Tchavdar, Sritharan, Rajeeva, Schloegl, Simon, Traykov, Vassil, Tuinenburg, Anton E, Velchev, Vasil, Vos, Marc A, Willich, Stefan N, Friede, Tim, Svendsen, Jesper Hastrup, Merkely, Bela, Seegers, J, Munoz-Exposito, P, Tichelbacker, T, Kirovo, A, Joerss, K, Macken, J, Misdaq, M, Rudolph, K, Mueller, A, Dommasch, M, Sinnecker, D, Sinner, M, Dissmann, R, Burmester, U, Behrens, S, Gregor, M, Stefanow, S, Rueb, N, Wolpert, C, Bimmel, D, Lieberz, C, Maier, L, Schwinger, R, Blaschke, F, Pieske, B, Groenefeld, G, Klein, G, Gardiwal, A, Szeplaki, G, Perge, P, Nossan, J Szavits, Rotkvic, L, Manola, S, Vinter, O, Benko, I, Brusic, S, Avdovic, E, Klasan, M, Bakotic, Z, Anic, A, Kowalczyk, E, Kucejko, T, Czechowska, A, Wybor, K, Ptaszynski, P, Qavoq, H, Guzik, P, Krauze, T, Sterlinski, M, Svetlosak, M, Martinek, J, Thamsborg, K, Schloett-Hyldelund, IM, Laage-Petersen, J, Vandenberk, B, van Soest, S, Giesebart, S, Kozak, M, Galuszka, J, Wijers, S, Dunnink, A, Sprenkeler, D, Arbelo, E, Trucco, E, Vidorreta, S, Kentta, T, Pelli, A, Huikuri, P, Koski, P, Karlsson, H, Ersgaard, D, Platonov, P, Klingenheben, T, Scharfe, M, Reinhold, T, Cree, M, Hnatkova, K, Gerhardt, J, Rizas, K, Hamm, W, Roever, C, Harden, M, Kessel, B, Berg, A, Apel, S, Walker, F, Kirchhof, N, Goerlitz, A, Molitor, A, Heinrich, J, Annetzberger, S, Fuchs, B, Landwehr, A, Merk, A, Wilke, A, Hennecke, C, and Mansch, R

Subjects
Science & Technology, Cardiac & Cardiovascular Systems, SEX-DIFFERENCES, SEATTLE HEART-FAILURE, RISK STRATIFICATION, EJECTION FRACTION, Sudden cardiac death, Risk factors, MYOCARDIAL-INFARCTION, CARDIOVERTER-DEFIBRILLATOR THERAPY, Implantable cardioverter defibrillator, Cardiovascular System & Cardiology, APPROPRIATE SHOCKS, Mortality, PRIMARY PREVENTION, PROPORTIONAL RISK, Life Sciences & Biomedicine
Abstract

AIMS: The clinical effectiveness of primary prevention implantable cardioverter defibrillator (ICD) therapy is under debate. The EUropean Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators (EU-CERT-ICD) aims to assess its current clinical value. METHODS AND RESULTS: The EU-CERT-ICD is a prospective investigator-initiated non-randomized, controlled, multicentre observational cohort study performed in 44 centres across 15 European Union countries. We will recruit 2250 patients with ischaemic or dilated cardiomyopathy and a guideline indication for primary prophylactic ICD implantation. This sample will include 1500 patients at their first ICD implantation and 750 patients who did not receive a primary prevention ICD despite having an indication for it (non-randomized control group). The primary endpoint is all-cause mortality; the co-primary endpoint in ICD patients is time to first appropriate shock. Secondary endpoints include sudden cardiac death, first inappropriate shock, any ICD shock, arrhythmogenic syncope, revision procedures, quality of life, and cost-effectiveness. At baseline (and prior to ICD implantation if applicable), all patients undergo 12-lead electrocardiogram (ECG) and Holter ECG analysis using multiple advanced methods for risk stratification as well as detailed documentation of clinical characteristics and laboratory values. Genetic biobanking is also organized. As of August 2018, baseline data of 2265 patients are complete. All subjects will be followed for up to 4.5 years. CONCLUSIONS: The EU-CERT-ICD study will provide a necessary update about clinical effectiveness of primary prophylactic ICD implantation. This study also aims for improved risk stratification and patient selection using clinical and ECG risk markers. ispartof: ESC HEART FAILURE vol:6 issue:1 pages:182-193 ispartof: location:England status: published

Published
2019

28. Rationale and design of the EU‐CERT‐ICD prospective study:comparative effectiveness of prophylactic ICD implantation

Author

Zabel, M. (Markus), Sticherling, C. (Christian), Willems, R. (Rik), Lubinski, A. (Andrzej), Bauer, A. (Axel), Bergau, L. (Leonard), Braunschweig, F. (Frieder), Brugada, J. (Josep), Brusich, S. (Sandro), Conen, D. (David), Cygankiewicz, I. (Iwona), Flevari, P. (Panagiota), Taborsky, M. (Milos), Hansen, J. (Jim), Hasenfuss, G. (Gerd), Hatala, R. (Robert), Huikuri, H. V. (Heikki V.), Iovev, S. (Svetoslav), Kaeaeb, S. (Stefan), Kaliska, G. (Gabriela), Kasprzak, J. D. (Jaroslaw D.), Luethje, L. (Lars), Malik, M. (Marek), Novotny, T. (Tomas), Pavlovic, N. (Nikola), Schmidt, G. (Georg), Shalganov, T. (Tchavdar), Sritharan, R. (Rajeeva), Schloegl, S. (Simon), Nossan, J. S. (Janko Szavits), Traykov, V. (Vassil), Tuinenburg, A. E. (Anton E.), Velchev, V. (Vasil), Vos, M. A. (Marc A.), Willich, S. N. (Stefan N.), Friede, T. (Tim), Svendsen, J. H. (Jesper Hastrup), Merkely, B. (Bela), Seegers, J. (J.), Munoz-Exposito, P. (P.), Tichelbacker, T. (T.), Kirovo, A. (A.), Sritharan, R. (R.), Joerss, K. (K.), Macken, J. (J.), Misdaq, M. (M.), Rudolph, K. (K.), Schmidt, G. (G.), Mueller, A. (A.), Dommasch, M. (M.), Sinnecker, D. (D.), Sinner, M. (M.), Bauer, A. (A.), Dissmann, R. (R.), Burmester, U. (U.), Behrens, S. (S.), Gregor, M. (M.), Stefanow, S. (S.), Rueb, N. (N.), Wolpert, C. (C.), Bimmel, D. (D.), Lieberz, C. (C.), Maier, L. (L.), Schwinger, R. (R.), Blaschke, F. (F.), Pieske, B. (B.), Groenefeld, G. (G.), Klein, G. (G.), Gardiwal, A. (A.), Merkely, B. (B.), Szeplaki, G. (G.), Perge, P. (P.), Nossan, J. S. (J. Szavits), Rotkvic, L. (L.), Pavlovic, N. (N.), Manola, S. (S.), Vinter, O. (O.), Benko, I. (I.), Brusic, S. (S.), Avdovic, E. (E.), Klasan, M. (M.), Bakotic, Z. (Z.), Anic, A. (A.), Lubinski, A. (A.), Kowalczyk, E. (E.), Kucejko, T. (T.), Czechowska, A. (A.), Wybor, K. (K.), Cygankiewicz, I. (I.), Ptaszynski, P. (P.), Kasprzak, J. (J.), Qavoq, H. (H.), Guzik, P. (P.), Krauze, T. (T.), Sterlinski, M. (M.), Hatala, R. (R.), Svetlosak, M. (M.), Kaliska, G. (G.), Martinek, J. (J.), Thamsborg, K. (K.), Hansen, J. (J.), Schloett-Hyldelund, I. M. (I. M.), Laage-Petersen, J. (J.), Willems, R. (R.), Vandenberk, B. (B.), van Soest, S. (S.), Traykov, V. (V.), Iovev, S. (S.), Shalganov, T. (T.), Sticherling, C. (C.), Conen, D. (D.), Giesebart, S. (S.), Novotny, T. (T.), Kozak, M. (M.), Taborsky, M. (M.), Galuszka, J. (J.), Tuinenburg, A. E. (A. E.), Wijers, S. (S.), Dunnink, A. (A.), Sprenkeler, D. (D.), Brugada, J. (J.), Arbelo, E. (E.), Trucco, E. (E.), Vidorreta, S. (S.), Huikuri, H. (H.), Kentta, T. (T.), Pelli, A. (A.), Huikuri, P. (P.), Koski, P. (P.), Braunschweig, F. (F.), Karlsson, H. (H.), Ersgaard, D. (D.), Platonov, P. (P.), Klingenheben, T. (T.), Scharfe, M. (M.), Reinhold, T. (T.), Cree, M. (M.), Hnatkova, K. (K.), Gerhardt, J. (J.), Rizas, K. (K.), Hamm, W. (W.), Roever, C. (C.), Harden, M. (M.), Kessel, B. (B.), Berg, A. (A.), Apel, S. (S.), Walker, F. (F.), Kirchhof, N. (N.), Goerlitz, A. (A.), Molitor, A. (A.), Heinrich, J. (J.), Annetzberger, S. (S.), Fuchs, B. (B.), Landwehr, A. (A.), Merk, A. (A.), Wilke, A. (A.), Hennecke, C. (C.), Mansch, R. (R.), Zabel, M. (Markus), Sticherling, C. (Christian), Willems, R. (Rik), Lubinski, A. (Andrzej), Bauer, A. (Axel), Bergau, L. (Leonard), Braunschweig, F. (Frieder), Brugada, J. (Josep), Brusich, S. (Sandro), Conen, D. (David), Cygankiewicz, I. (Iwona), Flevari, P. (Panagiota), Taborsky, M. (Milos), Hansen, J. (Jim), Hasenfuss, G. (Gerd), Hatala, R. (Robert), Huikuri, H. V. (Heikki V.), Iovev, S. (Svetoslav), Kaeaeb, S. (Stefan), Kaliska, G. (Gabriela), Kasprzak, J. D. (Jaroslaw D.), Luethje, L. (Lars), Malik, M. (Marek), Novotny, T. (Tomas), Pavlovic, N. (Nikola), Schmidt, G. (Georg), Shalganov, T. (Tchavdar), Sritharan, R. (Rajeeva), Schloegl, S. (Simon), Nossan, J. S. (Janko Szavits), Traykov, V. (Vassil), Tuinenburg, A. E. (Anton E.), Velchev, V. (Vasil), Vos, M. A. (Marc A.), Willich, S. N. (Stefan N.), Friede, T. (Tim), Svendsen, J. H. (Jesper Hastrup), Merkely, B. (Bela), Seegers, J. (J.), Munoz-Exposito, P. (P.), Tichelbacker, T. (T.), Kirovo, A. (A.), Sritharan, R. (R.), Joerss, K. (K.), Macken, J. (J.), Misdaq, M. (M.), Rudolph, K. (K.), Schmidt, G. (G.), Mueller, A. (A.), Dommasch, M. (M.), Sinnecker, D. (D.), Sinner, M. (M.), Bauer, A. (A.), Dissmann, R. (R.), Burmester, U. (U.), Behrens, S. (S.), Gregor, M. (M.), Stefanow, S. (S.), Rueb, N. (N.), Wolpert, C. (C.), Bimmel, D. (D.), Lieberz, C. (C.), Maier, L. (L.), Schwinger, R. (R.), Blaschke, F. (F.), Pieske, B. (B.), Groenefeld, G. (G.), Klein, G. (G.), Gardiwal, A. (A.), Merkely, B. (B.), Szeplaki, G. (G.), Perge, P. (P.), Nossan, J. S. (J. Szavits), Rotkvic, L. (L.), Pavlovic, N. (N.), Manola, S. (S.), Vinter, O. (O.), Benko, I. (I.), Brusic, S. (S.), Avdovic, E. (E.), Klasan, M. (M.), Bakotic, Z. (Z.), Anic, A. (A.), Lubinski, A. (A.), Kowalczyk, E. (E.), Kucejko, T. (T.), Czechowska, A. (A.), Wybor, K. (K.), Cygankiewicz, I. (I.), Ptaszynski, P. (P.), Kasprzak, J. (J.), Qavoq, H. (H.), Guzik, P. (P.), Krauze, T. (T.), Sterlinski, M. (M.), Hatala, R. (R.), Svetlosak, M. (M.), Kaliska, G. (G.), Martinek, J. (J.), Thamsborg, K. (K.), Hansen, J. (J.), Schloett-Hyldelund, I. M. (I. M.), Laage-Petersen, J. (J.), Willems, R. (R.), Vandenberk, B. (B.), van Soest, S. (S.), Traykov, V. (V.), Iovev, S. (S.), Shalganov, T. (T.), Sticherling, C. (C.), Conen, D. (D.), Giesebart, S. (S.), Novotny, T. (T.), Kozak, M. (M.), Taborsky, M. (M.), Galuszka, J. (J.), Tuinenburg, A. E. (A. E.), Wijers, S. (S.), Dunnink, A. (A.), Sprenkeler, D. (D.), Brugada, J. (J.), Arbelo, E. (E.), Trucco, E. (E.), Vidorreta, S. (S.), Huikuri, H. (H.), Kentta, T. (T.), Pelli, A. (A.), Huikuri, P. (P.), Koski, P. (P.), Braunschweig, F. (F.), Karlsson, H. (H.), Ersgaard, D. (D.), Platonov, P. (P.), Klingenheben, T. (T.), Scharfe, M. (M.), Reinhold, T. (T.), Cree, M. (M.), Hnatkova, K. (K.), Gerhardt, J. (J.), Rizas, K. (K.), Hamm, W. (W.), Roever, C. (C.), Harden, M. (M.), Kessel, B. (B.), Berg, A. (A.), Apel, S. (S.), Walker, F. (F.), Kirchhof, N. (N.), Goerlitz, A. (A.), Molitor, A. (A.), Heinrich, J. (J.), Annetzberger, S. (S.), Fuchs, B. (B.), Landwehr, A. (A.), Merk, A. (A.), Wilke, A. (A.), Hennecke, C. (C.), and Mansch, R. (R.)

Abstract

Aims: The clinical effectiveness of primary prevention implantable cardioverter defibrillator (ICD) therapy is under debate. The EUropean Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators (EU‐CERT‐ICD) aims to assess its current clinical value. Methods and results: The EU‐CERT‐ICD is a prospective investigator‐initiated non‐randomized, controlled, multicentre observational cohort study performed in 44 centres across 15 European Union countries. We will recruit 2250 patients with ischaemic or dilated cardiomyopathy and a guideline indication for primary prophylactic ICD implantation. This sample will include 1500 patients at their first ICD implantation and 750 patients who did not receive a primary prevention ICD despite having an indication for it (non‐randomized control group). The primary endpoint is all‐cause mortality; the co‐primary endpoint in ICD patients is time to first appropriate shock. Secondary endpoints include sudden cardiac death, first inappropriate shock, any ICD shock, arrhythmogenic syncope, revision procedures, quality of life, and cost‐effectiveness. At baseline (and prior to ICD implantation if applicable), all patients undergo 12‐lead electrocardiogram (ECG) and Holter ECG analysis using multiple advanced methods for risk stratification as well as detailed documentation of clinical characteristics and laboratory values. Genetic biobanking is also organized. As of August 2018, baseline data of 2265 patients are complete. All subjects will be followed for up to 4.5 years. Conclusions: The EU‐CERT‐ICD study will provide a necessary update about clinical effectiveness of primary prophylactic ICD implantation. This study also aims for improved risk stratification and patient selection using clinical and ECG risk markers.

Published
2019

38. Rationale, objectives, and design of the EUTrigTreat clinical study: A prospective observational study for arrhythmia risk stratification and assessment of interrelationships among repolarization markers and genotype

Author

Seegers, J. Vos, M.A. Flevari, P. Willems, R. Sohns, C. Vollmann, D. Lüthje, L. Kremastinos, D.T. Flor, V. Meine, M. Tuinenburg, A. Myles, R.C. Simon, D. Brockmöller, J. Friede, T. Hasenfuß, G. Lehnart, S.E. Zabel, M.

Abstract

Aims The EUTrigTreat clinical study has been designed as a prospective multicentre observational study and aims to (i) risk stratify patients with an implantable cardioverter defibrillator (ICD) for mortality and shock risk using multiple novel and established risk markers, (ii) explore a link between repolarization biomarkers and genetics of ion (Ca 2, Na, K) metabolism, (iii) compare the results of invasive and non-invasive electrophysiological (EP) testing, (iv) assess changes of non-invasive risk stratification tests over time, and (v) associate arrythmogenomic risk through 19 candidate genes. Methods and resultsPatients with clinical ICD indication are eligible for the trial. Upon inclusion, patients will undergo non-invasive risk stratification, including beat-to-beat variability of repolarization (BVR), T-wave alternans, T-wave morphology variables, ambient arrhythmias from Holter, heart rate variability, and heart rate turbulence. Non-invasive or invasive programmed electrical stimulation will assess inducibility of ventricular arrhythmias, with the latter including recordings of monophasic action potentials and assessment of restitution properties. Established candidate genes are screened for variants. The primary endpoint is all-cause mortality, while one of the secondary endpoints is ICD shock risk. A mean follow-up of 3.3 years is anticipated. Non-invasive testing will be repeated annually during follow-up. It has been calculated that 700 patients are required to identify risk predictors of the primary endpoint, with a possible increase to 1000 patients based on interim risk analysis. ConclusionThe EUTrigTreat clinical study aims to overcome current shortcomings in sudden cardiac death risk stratification and to answer several related research questions. The initial patient recruitment is expected to be completed in July 2012, and follow-up is expected to end in September 2014. © The Author 2011.

Published
2012

39. Voorwoord

Author

Jansen, P.G.W., Seegers, J., and Management and Organisation

Published
2006

Catalog

Books, media, physical & digital resources
See catalog results