70 results on '"Sedlacek K"'
Search Results
2. 1555Excellent response rate to cardiac resynchronization therapy guided with magnetic resonance imaging
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Kockova, R., Sedlacek, K., Wichterle, D., Sikula, V., Tintera, J., Sukupova, L., Kautznerova, D., Segetova, M., Praveckova, A., Langova, R., Kryze, L., El-Husseini, W., and Kautzner, J.
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- 2016
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3. Phakoemulsifikation, die Methode der Wahl in der Kataraktchirurgie
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Kuchynka, P., Křepelková, J., Novák, P., Sedláček, K., Neuhann, Thomas, editor, Hartmann, Christian, editor, and Rochels, Rainer, editor
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- 1993
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4. Spiegelmikroskopische und rasterelektronenmikroskopische Untersuchung von Nd: YAG-Laser-Defekten in den PMMA-Hinterkammerlinsen
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Cendelin, J., Sedlacek, K., Korynta, J., Klepacek, I., Robert, Yves C. A., editor, Gloor, Balder, editor, Hartmann, Christian, editor, and Rochels, Rainer, editor
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- 1993
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5. ICD therapy in patients enlisted for heart transplantation between 2007-2010: a single centre experience
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Jurkuvenas, P., Sedlacek, K., Malek, I., Hoskova, L., and Kautzner, J.
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- 2011
6. Poster session: Dobutamine stress echo
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Kockova, R, Tintera, J, Kautznerova, D, Cerna, D, Sedlacek, K, Kryze, L, Sikula, V, Segetova, M, and Kautzner, J
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- 2012
7. RIGHT VENTRICULAR DYSFUNCTION IS ASSOCIATED WITH DEFIBRILLATION TEST FAILURE: 22.7
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Stefan, L., Sedlacek, K., Vancura, V., Bytesnik, J., and Kautzner, J.
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- 2011
8. 534Cardiac resynchronization therapy guided by cardiac magnetic resonance imaging: a prospective, single centre randomized study
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Sedlacek, K, primary, Kockova, R, additional, Wichterle, D, additional, and Kautzner, J, additional
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- 2018
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9. Lid v budování Ostravska po válce proti fašismu. Viz rubriku Literatura v dnešním číle
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Vávlavík, B., Balcárková, L., and Sedláček, K. F.
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- 1950
10. Otázky a odpovědi
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Klečka, J., Sedláček, J., Karásek, V., Sedláček, K., Kvasnička, Jos., Hrudka, Ad., Lisertová, M., Fořt, J., and Karpas, J.
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- 1914
11. P2086Permanent pacing after heart transplantation: factors associated with its need
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Lefflerova, K., primary, Melenovsky, V., additional, Pirk, J., additional, Pokorna, E., additional, Sedlacek, K., additional, and Kautzner, J., additional
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- 2017
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12. P1572Lack of agreement between mechanically and electrically defined optimal left ventricular lead placement target sites
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Sedlacek, K., primary, Wichterle, D., additional, Kockova, R., additional, and Kautzner, J., additional
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- 2017
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13. MODERATED EPOSTERS1385Longitudinal strain assessment in dilated cardiomyopathy patients using a novel accelerated DENSE sequence1407Simultaneous T1 and T2 cardiac quantification with CABIRIA: initial clinical experience1423Head-to-head comparison of acceleration algorithms in 4-dimensional flow CMR1502Left ventricular function and size evaluated by hybrid cardiac positron emission tomography-magnetic resonance: Intraindividual comparison of left ventricular ejection fraction and ventricular volumes derived by two modalities1510Left Atrium assessed by Cardiovascular Magnetic Resonance at 1.5 and 3 Tesla – age and gender effects1514Comparison of Free Breathing Cardiac MRI Radial technique to the Standard Multi breath-hold cine SSFP CMR technique for the assessment of LV Volumes and Function1536Self-navigated free-breathing isotropic 3D whole heart phase sensitive inversion recovery magnetic resonance without navigator for detection of myocardial infarction1547Assessment of Right Ventricular Strain Using Myocardial Deformation Recovery Semi Automated Technique: Initial Experience and Normal Values1586Tissue tracking myocardial deformation analysis and prediction of left ventricular remodeling in acute myocardial infarction1589Investigating strategies for optimal 31P MRS clinical cardiac at 3T: Initial Results1620Quantitative Criteria for the Diagnosis of the Congenital Absence of Pericardium by Cardiac Magnetic Resonance1632Widespread tissue injury during acute myocardial infarction: evidence from advanced CMR relaxometry1322Computed tomography coronary angiography verSus sTRess cArdiac magneTic rEsonance for the manaGement of sYmptomatic revascularized patients: a cost effectiveness study (STRATEGY study)1339Comparison of low- versus high-dose of gadobutrol for late gadolinium enhancement imaging at 1.5 Tesla: a clinical feasibility study1347Multi-parametric Cardiac Magnetic Resonance for Prediction of Cardiac Complications in Thalassemia Intermedia: a Prospective Multicenter Study1461Prognostic value of Cardiovascular Magnetic Resonance derived indexes of myocardial fibrosis in heart transplant recipients1523The role of CMR in the acute phase of hospitalization: changing paradigms1542Preoperative CMR-based score predict ventricular response after surgical left ventricular reconstruction in ischemic heart failure patients1555Excellent response rate to cardiac resynchronization therapy guided with magnetic resonance imaging1626The ECG as a predictor of arrhythmogenic substrate on Cardiac Magnetic Resonance Imaging in patients undergoing ablation for premature ventricular contractions1649Comparison of T1-mapping at 3.0T CMR and angiographic APPROACH score for area at risk assessment in ST-segment elevation myocardial infarction1340Pathological correlates of left bundle branch disease in patients with non-ischemic cardiomyopathy: a cardiovascular magnetic resonance study1342Myocardial remodelling and fibrosis in nonischaemic dilated cardiomyopathy: insights from cardiovascular magnetic resonance1411The association between fibrosis and contractile dysfunction in hypertrophic cardiomyopathy assessed by cardiovascular magnetic resonance1622Persistent myocardial inflammation due to intramyocardial haemorrhage in reperfused STEMI as a precursor to adverse LV remodelling - insights from multi-parametric mapping1566Semiquantitative analysis of low and high b value DWI for detecting myocardial edema in acute myocarditis1567Value of Cardiac MRI In Detecting Coronary Artery Disease In Newly Diagnosed Systolic Dysfunction1570Usefulness of cardiac magnetic resonance in tuberous sclerosis complex1578Papillary muscles offer further insight into hypertrophied hearts: a cardiovascular magnetic resonance study1627Diagnostic and clinical implications of CMR timing (early versus late) in patients with troponin positive acute coronary syndromes and unobstructed coronary arteries: Table 1.
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Tayal, Upasana, primary, Kallifatidis, Alexandros, primary, Garg, P., primary, Beitzke, D., primary, Funk, Stephanie, primary, Kolker, Shimon, primary, Rutz, Tobias, primary, Safdar, Komal S, primary, Valente, F., primary, Murdoch, R., primary, Macaione, F., primary, Dastidar, Amardeep Ghosh, primary, Pontone, Gianluca, primary, Grigoratos, Chrysanthos, primary, Meloni, Antonella, primary, Pedrotti, Patrizia, primary, De Garate, Estefania, primary, Careri, Giulia, primary, Kockova, R., primary, Oebel, S., primary, Nazir, Sheraz A., primary, Barison, A, primary, Swoboda, Peter P, primary, Bulluck, Heerajnarain, primary, Broncano, J., primary, Desroche, L.M., primary, Bermejo, Zorba Blázquez, primary, Kozor, Rebecca, primary, Scott, Andrew D, additional, Wage, Rick, additional, Ferreira, Pedro, additional, Pennell, Dudley, additional, Zhong, Xiaodong, additional, Epstein, Fred, additional, Firmin, David, additional, Prasad, Sanjay, additional, Prousalis, Anastasios, additional, Mouratoglou, Sophia-Anastasia, additional, Giannakoulas, George, additional, Deligianni, Xenia, additional, Bakaloudis, Michail, additional, Magganaris, Nikolaos, additional, Sianos, George, additional, Karvounis, Haralampos, additional, Santini, Francesco, additional, Aziz, R., additional, Foley, J.R.J., additional, Fent, G., additional, Musa, T.A., additional, Haaf, P., additional, Dobson, L., additional, Swoboda, P.P., additional, Greenwood, J.P., additional, Plein, S., additional, Geest, R.J.V.D., additional, Westenberg, J.J.M., additional, Rasul, S., additional, Wadsak, W., additional, Mitterhauser, M., additional, Nolz, R., additional, Stelzmueller, M., additional, Loewe, C., additional, Hacker, M., additional, Kermer, Josephine, additional, Dogangüzel, Serkan, additional, von Knobelsdorff-Brenkenhoff, Florian, additional, Schulz-Menger, Jeanette, additional, Weisz, Giora, additional, Bogot, Naama, additional, Halpern, Irit Hadas, additional, Wolak, Arik, additional, Ginami, Giulia, additional, Piccini, Davide, additional, Coppo, Simone, additional, Vincenti, Gabriella, additional, Stuber, Matthias, additional, Schwitter, Jürg, additional, Gao, Xuexin, additional, Ambach, Stephanie, additional, Taylor, Michal D, additional, Moore, Ryan, additional, Taylor, Robin J, additional, Toro-Salazar, Olga, additional, Jeffries, John L, additional, Bartone, Cheryl, additional, Raman, Subha V, additional, Mazur, Wojciech, additional, Rodriguez-Palomares, J.F., additional, Gutierrez, L., additional, Pineda, V., additional, Agliano, B., additional, Galian, L., additional, Teixido, G., additional, Gonzalez-Alujas, M.T., additional, Evangelista, A., additional, Garcia-Dorado, D., additional, Gandy, S., additional, Nicholas, R., additional, Houston, G., additional, Martin, P., additional, Muir, J., additional, Matthew, S., additional, Ramkumar, P. Guntur-, additional, Cavin, I., additional, Barison, A., additional, Pescetelli, I., additional, Pali, F., additional, Pizzino, F., additional, Terrizzi, A., additional, Di Lisi, D., additional, Novo, G., additional, Todiere, G., additional, Assennato, P., additional, Novo, S., additional, Aquaro, G.D., additional, McAlindon, Elisa, additional, Rodrigues, Jonathan, additional, Baritussio, Anna, additional, Scatteia, Alessandra, additional, De Garate, Estefania, additional, Benny Lawton, Chris, additional, Erdei, Tamas, additional, Szantho, Gergely, additional, Hamilton, Mark, additional, Bucciarelli-Ducci, Chiara, additional, Andreini, Daniele, additional, Rota, Cristina, additional, Guglielmo, Marco, additional, Mushtaq, Saima, additional, Baggiano, Andrea, additional, Beltrama, Virginia, additional, Solbiati, Anna, additional, Guaricci, Andrea I., additional, Pepi, Mauro, additional, Bratis, Konstantinos, additional, Henningson, Markus, additional, Dell'Omodarme, Matteo, additional, Puntmann, Valentina O., additional, Nagel, Eike, additional, Giunta, Nicola, additional, Giuliano, Pietro, additional, Neri, Maria Giovanna, additional, Restaino, Gennaro, additional, Renne, Stefania, additional, Quota, Alessandra, additional, Positano, Vincenzo, additional, De Marchi, Daniele, additional, Pepe, Alessia, additional, Campadello, Paola, additional, Masciocco, Gabriella, additional, Facchetti, Rita, additional, Milazzo, Angela, additional, Quattrocchi, Giuseppina, additional, Giannattasio, Cristina, additional, Frigerio, Maria, additional, Roghi, Alberto, additional, Rimoldi, Ornella, additional, Ghosh Dastidar, Amardeep, additional, Amadu, Antonio, additional, Venuti, Giuseppe, additional, Rodrigues, Jonathan C., additional, Castelvecchio, Serenella, additional, Camporeale, Antonia, additional, Secchi, Francesco, additional, Menicanti, Lorenzo, additional, Lombardi, Massimo, additional, Sedlacek, K., additional, Wichterle, D., additional, Sikula, V., additional, Tintera, J., additional, Sukupova, L., additional, Kautznerova, D., additional, Segetova, M., additional, Praveckova, A., additional, Langova, R., additional, Kryze, L., additional, El-Husseini, W., additional, Kautzner, J., additional, Dinov, B., additional, Arya, A., additional, Hilbert, S., additional, Sommer, P., additional, Bollmann, A., additional, Hindricks, G., additional, Paetsch, I., additional, Jahnke, C., additional, Greenwood, John P., additional, Shetye, Abhishek, additional, Khan, Jamal N., additional, Singh, Anvesha, additional, Kanagala, Prathap, additional, Swarbrick, Daniel, additional, Gulsin, Gaurav, additional, Graham-Brown, Matthew, additional, Gershlick, Anthony, additional, McCann, Gerry P., additional, Liga, Riccardo, additional, Bennatti, Elena, additional, Barison, Andrea, additional, Todiere, Giancarlo, additional, Aquaro, Giovanni Donato, additional, Emdin, Michele, additional, Masci, Pier Giorgio, additional, Ortalda, A, additional, Todiere, G, additional, Grigoratos, C, additional, Vergaro, G, additional, Mirizzi, G, additional, Martini, N, additional, De Marchi, D, additional, Keilberg, P, additional, Passino, C, additional, Aquaro, GD, additional, Emdin, M, additional, McDiarmid, Adam K, additional, Erhayiem, Bara, additional, Fent, Graham J, additional, Dobson, Laura E, additional, Garg, Pankaj, additional, Musa, Tarique A, additional, Foley, James R, additional, Page, Stephen P, additional, Greenwood, John P, additional, Plein, Sven, additional, Rosmini, Stefania, additional, Abdel-Gadir, Amna, additional, Bhuva, Anish, additional, Treibel, Thomas A, additional, White, Steven K, additional, Fontana, Marianna, additional, Ramlall, Manish, additional, Hamarneh, Ashraf, additional, Sirker, Alex, additional, Herrey, Anna, additional, Manisty, Charlotte, additional, Yellon, Derek M, additional, Kellman, Peter, additional, Moon, James C, additional, Hausenloy, Derek J, additional, Luna, A., additional, Noguerol, T. Martin –, additional, Caro, P., additional, Toro-Cebada, R., additional, Gonzalez, J. Sanchez –, additional, Milleron, O., additional, Safar, B., additional, Lavie-Badie, Y., additional, Millischer, D., additional, Abtan, J., additional, Jondeau, G., additional, Cuesta, Emilio, additional, Rosillo, Sandra O., additional, Guzmán, Gabriela, additional, Pinilla, Inmaculada, additional, González, Óscar, additional, Caro, Juan, additional, Ponz, Inés, additional, López, Teresa, additional, Refoyo, Elena, additional, Nordin, Sabrina, additional, Castelleti, Silvia, additional, Captur, Gabriella, additional, Steeds, Rick, additional, Baig, Shanat, additional, Grieve, Stuart M, additional, Figtree, Gemma A, additional, Singhal, Priyanka, additional, Strange, Julian, additional, Nightingale, Angus, additional, Baumbach, Andreas, additional, Johnson, Tom, additional, and Delgado, Victoria, additional
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- 2016
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14. Methodologies for hazard analysis and risk assessment in the petroleum refining and storage industry — Part I
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Hope, S., Eddershaw, B. W., Joanny, L., Bjordal, E. N., Diack, H. M., Ortone, G., Payne, F. G., Searson, A. H., Sedlacek, K. W., van Strien, W., and Ad-Hoc Risk Assessment Group of the Oil Companies' International Study Group for Conservation of Clean Air and Water in Europe (CONCAWE)
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- 1984
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15. 1030Role of cardiac magnetic resonance and echocardiography prior to cardiac resynchronization therapy
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Kockova, R, primary, Tintera, J, additional, Kautznerova, D, additional, Cerna, D, additional, Sedlacek, K, additional, Kryze, L, additional, El-Husseini, W, additional, Sikula, V, additional, Segetova, M, additional, and Kautzner, J, additional
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- 2013
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16. Small left atrium and mild mitral regurgitation predict super-response to cardiac resynchronization therapy
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Stefan, L., primary, Sedlacek, K., additional, Cerna, D., additional, Kryze, L., additional, Vancura, V., additional, Marek, T., additional, and Kautzner, J., additional
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- 2012
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17. Hot topics: CRT and ICD therapy
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Biffi, M., primary, Exner, D., additional, Crossley, G., additional, Ramza, B., additional, Coutu, B., additional, Tomassoni, G. F., additional, Kranig, W., additional, Voss, F., additional, Teo, K. M., additional, Stuart, A. G., additional, Tomassoni, G., additional, Baker, J., additional, Corbisiero, R., additional, Love, C., additional, Martin, D., additional, Niazi, I., additional, Sheppard, R., additional, Worley, S., additional, Jurkuvenas, P., additional, Sedlacek, K., additional, Malek, I., additional, Hoskova, L., additional, Kautzner, J., additional, Landolina, M., additional, Lunati, M., additional, Gasparini, M., additional, Santini, M., additional, Giannola, G., additional, Ammirati, F., additional, Ricci, R., additional, Valsecchi, S., additional, Folino, A. F., additional, Vaccari, D., additional, Zanotto, G., additional, Marras, E., additional, Bertaglia, M., additional, Chiusso, F., additional, Buja, G., additional, Veneto Region, H. M. S. G., additional, Strunk-Mueller, C., additional, Meyer Zu Vilsendorf, D., additional, Stellbrink, C., additional, Senges, J., additional, Schwab, J. O., additional, Gordon, B. J., additional, Fazal, I. A., additional, Plummer, C. J., additional, Mccomb, J. M., additional, Kleemann, T., additional, Strauss, M., additional, Hochadel, M., additional, Seidl, K., additional, and Zahn, R., additional
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- 2011
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18. Impact of cardiac resynchronization therapy on the severity of mitral regurgitation
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Di Biase, L., primary, Auricchio, A., additional, Mohanty, P., additional, Bai, R., additional, Kautzner, J., additional, Pieragnoli, P., additional, Regoli, F., additional, Sorgente, A., additional, Spinucci, G., additional, Ricciardi, G., additional, Michelucci, A., additional, Perrotta, L., additional, Faletra, F., additional, Mlcochova, H., additional, Sedlacek, K., additional, Canby, R., additional, Sanchez, J. E., additional, Horton, R., additional, Burkhardt, J. D., additional, Moccetti, T., additional, Padeletti, L., additional, and Natale, A., additional
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- 2011
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19. Isolated left ventricular pacing results in worse long-term clinical outcome when compared with biventricular pacing: a single-centre randomized study
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Sedlacek, K., primary, Burianova, L., additional, Mlcochova, H., additional, Peichl, P., additional, Marek, T., additional, and Kautzner, J., additional
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- 2010
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20. Attention and autonomic self-regulation.
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Cohen, Jonathan, Sedlacek, Keith, Cohen, J, and Sedlacek, K
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- 1983
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21. Survival rate and causes of death in patients with pacemakers: dependence on symptoms leading to pacemaker implantation.
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MÜLLER, Ch., CERNIN, J., GLOGAR, D., LACZKOVICS, A., MAYR, H., SCHEIBELHOFER, W., SCHMIDINGER, H., SCHUSTER, E., SEDLACEK, K., and KALIMAN, J.
- Abstract
The survival rate of 2256 patients with pacemakers was analyzed. Patients paced for Adams-Stokes equivalents (e.g. dizziness) showed a significantly better survival rate than did patients with pacemakers implanted for Adam-Stokes attacks or heart failure (P < 0.0001). The estimated survival of the latter two groups did not differ significantly. Of the deceased patients who had received a pacemaker for the treatment of heart failure, 54% died due to this condition despite pacemaker implantation. The relative percentage of cases of sudden death after pacemaer implantation was high in the groups with Adams-Stokes attacks (12%) and Adams-Stokes equivalents (13%). In patients paced for Adams-Stokes attacks, sudden death occured more frequently in the first year after pacemaker implantation (P<0.015) than during the following years. Therefore, inreased efforts should be made to monitor patients carefully after pacemaker implantation to enable prompt detection of malignant tachyarrhythmias, probably the cause of sudden death in a substantial number of patients with pacemakers. [ABSTRACT FROM PUBLISHER]
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- 1988
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22. Concepts of the Terms Susceptibility and Resistance as They Relate to Hearing Damage Due to Noise
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FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO, Sedlacek,K., FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO, and Sedlacek,K.
- Abstract
The author's definition of susceptibility and resistance is formulated on the basis of correlation between the injuring factor (noxa) and its effect by means of the probability that is expressed as the difference between the expected value given by the regression line and real value of the hearing loss. This defines susceptibility and, similarly, resistance as the probability of a given loss with the presumption of the average reactivity of the given person. Examples of application of such an evaluation of receptivity are shown., Edited trans. of Ceskoslovenska Otolaryngologie, v21 n1 p4-9 1972.
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- 1974
23. Abstracts
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Treibel, Thomas A., Fridman, Yaron, Hackman, Brianne, Kadakkal, Ajay, Sayeed, Aatif, Maanja, Maren, Daya, Hussein Abu, Moon, James C., Wong, Timothy C., Schelbert, Erik B., Duca, Franz, Kammerlander, Andreas A., Zotter-Tufaro, Caroline, Aschauer, Stefan, Bonderman, Diana, Mascherbauer, Julia, Schwitter, Juerg, Beigelman-Aubry, Catherine, Peguret, Nicolas, Stuber, Matthias, Delacoste, Jean, Belmondo, Bastien, Lovis, Alban, Simons, Julien, Long, Olivier, Grant, Kathleen, Berchier, Gregoire, Rohner, Chantal, Bonanno, Gabriele, Coppo, Simone, Ozsahin, Esat-Mahmut, Qanadli, Salah, Meuli, Reto, Bourhis, Jean, Ide, Seiko, Riesenkampff, Eugenie, Chiasson, David, Dipchand, Anne I., Kantor, Paul F., Chaturvedi, Rajiv R., Yoo, Shi-Joon, Grosse-Wortmann, Lars, Sandrini, C., Aquaro, GD, De Marchi, D, Ait Ali, L, Khraiche, D, Boddaert, N, Bonnet, D, Raimondi, F, Fridman, Yaron, Hackman, Brianne E., Kadakkal, Ajay, Daya, Hussein Abu, Wong, Timothy C., Schelbert, Erik B., Angela, Susana, Alberto, Cipriani, Manuel, De Lazzari, Federico, Marin, Francesca, Prevedello, Bendetta, Giorgi, Giorgio, De Conti, Giuseppe, Tarantini, Luisa, Cacciavillani, Emanuele, Bertaglia, Domenico, Corrado, Sabino, Iliceto, Martina, Perazzolo Marra, Camaioni, Claudia, Morlon, Lucas, Vergé, Marie-Philippe, Jais, Pierre, Roudaut, Raymond, Laurent, Francois, Lafitte, Stéphane, Cochet, Hubert, Réant, Patricia, Bohnen, S., Radunski, U. K., Lund, G. K., Senel, M., Avanesov, M., Tahir, E., Stehning, C., Adam, G., Blankenberg, S., Muellerleile, K., Khanji, Mohammed Y., Balawon, Armida, Boubertakh, Redha, Petersen, Steffen E, Hilbert, Sebastian, Spampinato, Ricardo, Oebel, Sabrina, Hindricks, Gerhard, Bollmann, Andreas, Jahnke, Cosima, Paetsch, Ingo, Goetschalckx, K., Bogaert, J., Desmet, W., Toth, A., Merkely, B., Janssens, S., Claus, P., Calvieri, C., Preda, M. B., Perfetti, A., Valaperta, R., Secchi, F., Fedele, F., Martelli, F., Lombardi, M., Reinstadler, Sebastian J., Eitel, Charlotte, Fuernau, Georg, de Waha, Suzanne, Desch, Steffen, Mende, Meinhard, Metzler, Bernhard, Schuler, Gerhard, Thiele, Holger, Eitel, Ingo, Maestrini, Viviana, Mun, Hong Cheang, Kotwinski, Paul, Rosmini, Stefania, Sanders, Julie, Lloyd, Guy, Dudley, J. Pennell, Kellman, Peter, Hugh, E. Montgomery, Manisty, Charlotte, James, C. Moon, James, S., Waterhouse, D.F., Murphy, T.M., Kenny, C., O'Hanlon, R., Bastiaenen, Rachel, Cox, Andrew T., Wijeyeratne, Yanushi, Colbeck, Nicholas, Pakroo, Nadia, Ahmed, Hammad, Bunce, Nick, Anderson, Lisa, Prasad, Sanjay, Sharma, Sanjay, Behr, Elijah R., Reid, A. B., Miller, C., Jovanovic, A., Woolfson, P., Abidin, N., Schmitt, M., Amadu, A.M., Rodrigues, J.C.L., Dastidar, A. Ghosh, Baritussio, A., Lawton, C., Venuti, G., Meloni, G.B., Conti, M., Bucciarelli-Ducci, C., Pontone, Gianluca, Andreini, Daniele, SoLbiati, Anna, Guglielmo, Marco, Mushtaq, Saima, Baggiano, Andrea, Beltrama, Virginia, Rota, Cristina, Guaricci, Andrea I., Pepi, Mauro, Wang, Yufei, Joannic, David, Juillion, Patrick, Delassus, P., Monnet, Aurélien, Lalande, Alain, Fontaine, Jean-Francois, Zweerink, A, Allaart, CP, Wu, L, Kuijer, JPA, Beek, AM, Croisille, P, Clarysse, P, van Rossum, AC, Nijveldt, R, Bulluck, Heerajnarain, Rosmini, Stefania, Abdel-Gadir, Amna, Bhuva, Anish, Treibel, Thomas A, White, Steven K, Hammond-Haley, Matthew, Sirker, Alex, Herrey, Anna, Manisty, Charlotte, Yellon, Derek M, Kellman, Peter, Moon, James C, Hausenloy, Derek J, Garg, P., Hassell, M, Foley, J., Ripley, D.P., Dobson, L., Swoboda, P.P., Fent, G., Musa, T.A., Erhayiem, B., Haaf, P., Greenwood, J.P., Nijveldt, R., Westenberg, J.J.M., Geest, R.J.V.D., Plein, S., Rodrigues, Jonathan C L, Amadu, Antonio Matteo, Dastidar, Amardeep Ghosh, Szantho, Gergley, Lyen, Stephen, Godsave, Cattleya, Ratcliffe, Laura E K, Burchell, Amy E, Hart, Emma C, Hamilton, Mark C K, Nightingale, Angus K, Paton, Julian F R, Manghat, Nathan E, Bucciarelli-Ducci, Chiara, Hafyane, Tarik, Teixeira, Tiago, Greiser, Andreas, Mongeon, Francois Pierre, Haifa, Almutairi, Mohammed, Khanji, Redha, Boubertakh, Marc, Miquel, Steffen, Petersen, Greulich, S., Kitterer, D., Latus, J., Henes, J., Kurmann, R., Gloekler, S., Wahl, A., Buss, S., Katus, H., Bobbo, M., Lombardi, M., Braun, N., Alscher, M.D., Sechtem, U., Mahrholdt, H., Meloni, A., Neri, M.G., Preziosi, P., Grassedonio, E., Schicchi, N., Keilberg, P., Pulini, S., Facchini, E., Positano, V., Pepe, A., Nazir, Sheraz A., Shetye, Abhishek, Khan, Jamal N., Singh, Anvesha, Kanagala, Prathap, Swarbrick, Daniel, Gulsin, Gaurav, Graham-Brown, Matthew, Squire, Iain, Gershlick, Anthony, McCann, Gerry P., Stefan Biesbroek, P., Amier, Raquel P., Teunissen, Paul F.A., Robbers, Lourens F.H.J., Beek, Aernout M., van Rossum, Albert C., Hofman, Mark B.M., van Royen, Niels, Nijveldt, Robin, Arenja, Nisha, Riffel, Johannes H, Djiokou, Charly Noel, Andre, Florian, Fritz, Thomas, Halder, Manuel, Thomas, Zelniker, Korosoglou, Grigorios, Katus, Hugo A, Buss, Sebastian J, Kammerlander, Andreas A., Schwaiger, Marianne L., Duca, Franz, Aschauer, Stefan, Marzluf, Beatrice A., Zotter-Tufaro, Caroline, Dalos, Daniel, Pfaffenberger, Stefan, Bonderman, Diana, Mascherbauer, Julia, Sayeed, Aatif, Fridman, Yaron, Hackman, Brianne, Kadakkal, Ajay, Maanja, Maren, Daya, Hussein Abu, Wong, Timothy C., Schelbert, Erik B., Ricci, F., Barison, A., Todiere, G., Gaeta, R., Galllina, S., Emdin, M., De Caterina, R., Aquaro, G.D., Bernhardt, Peter, Buckert, Dominik, Dyckmanns, Nils, Rottbauer, Wolfgang, Meierhofer, Christian, Kühn, Andreas, Shehu, Nerejda, Müller, Jan, Stern, Heiko, Ewert, Peter, Fratz, Sohrab, Vogt, Manfred, Devos, Daniel G.H., De Groote, Katya, Babin, Danilo, Demulier, Laurent, Taeymans, Yves, Westenberg, Jos J., Van Bortel, Luc, Segers, Patrick, Achten, Eric, De Schepper, Jean, Rietzschel, Ernst, Ruecker, Beate, Geiger, Julia, Makki, Malek, Burkhardt, Barbara, Kellenberger, Christian J., Buechel, Emanuela R. Valsangiacomo, Burkhardt, B.E.U., Kellenberger, C.J., Geiger, J., Ruecker, B., Buechel, E.R. Valsangiacomo, Kamphuis, Vivian P., Elbaz, Mohammed S.M., Kroft, Lucia J.M., van der Geest, Rob J., de Roos, Albert, Blom, Nico A., Westenberg, Jos J.M., Roest, Arno A.W., De Lazzari, Manuel, Cipriani, Alberto, Susana, Angela, Rizzo, Stefania, Giorgi, Benedetta, Carmelo, Lacognata, Bertaglia, Emanuele, Bauce, Barbara, Corrado, Domenico, Thiene, Gaetano, Marra, Martina Perazzolo, Basso, Cristina, Iliceto, Sabino, Nederend, I., Roest, A.A.W., van den Boogaard, P.J., ten Harkel, A.D.J., de Geus, J.C.N., Kroft, L.J.M., de Roos, A., Westenberg, J.J.M., Dux-Santoy, Lydia, Kale, Raquel, Teixido-Tura, Gisela, Maldonado, Giuliana, Huguet, Marina, Garcia-Dorado, David, Evangelista, Artur, Rodriguez-Palomares, Jose, Cavalcante, João L., Rijal, Shasank, Schindler, John T., Gleason, Thomas G., Lee, Joon S., Schelbert, Erik B., Rosmini, Stefania, Bulluck, Heerajnarain, Treibel, Thomas A, Bhuva, Anish, Abdel-Gadir, Amna, Culotta, Veronica, Merghani, Ahmed, Maestrini, Viviana, Herrey, Anna S, Kellman, Peter, Manisty, Charlotte, Moon, James C, Liu, B., Hayer, M.K., Baig, S., Shah, T., Rooney, S.J., Edwards, N.C., Steeds, R.P., Fent, G.J., Garg, P., Swoboda, P., Dobson, L.E., Musa, T.A., Foley, J.F., Haaf, P., Greenwood, J.P., Plein, S., Claessen, G., Schnell, F., Bogaert, J., Dymarkowski, S., Pattyn, N., Claus, P., Van Cleemput, J., Gerche, A. La, Heidbuchel, H., Behar, Jonathan, Toth, Daniel, Reiml, Sabrina, Panayiotou, Maria, Claridge, Simon, Jackson, Tom, Sohal, Manav, Webb, Jessica, O'Neill, Mark, Brost, Alexander, Mountney, Peter, Razavi, Reza, Rhode, Kawal, Rinaldi, Christopher Aldo, Oebel, S., Arya, A., Hilbert, S., Bollmann, A., Hindricks, G., Jahnke, C., Paetsch, I., Dinov, B., Baritussio, A., Perazzolo Marra, M., Ghosh Dastidar, A., Rodrigues, J., Zorzi, A., Susana, A., Scatteia, A., De Garate, E., Mattesi, G., Strange, J., Corrado, D., Bucciarelli-Ducci, C., Ranjit Arnold, J., Jerosch-Herold, Michael, Karamitsos, Theodoros D., Francis, Jane M., Bhamra-Ariza, Paul, Sarwar, Rizwan, Choudhury, Robin, Selvanayagam, Joseph B., Neubauer, Stefan, Tayal, Upasana, Scott, Andrew D, Wage, Rick, Ferreira, Pedro, Pennell, Dudley, Zhong, Xiaodong, Epstein, Fred, Firmin, David, Prasad, Sanjay, Kallifatidis, Alexandros, Prousalis, Anastasios, Mouratoglou, Sophia-Anastasia, Giannakoulas, George, Deligianni, Xenia, Bakaloudis, Michail, Magganaris, Nikolaos, Sianos, George, Karvounis, Haralampos, Santini, Francesco, Garg, P., Aziz, R., Foley, J.R.J., Fent, G., Musa, T.A., Haaf, P., Dobson, L., Swoboda, P.P., Greenwood, J.P., Plein, S., Geest, R.J.V.D., Westenberg, J.J.M., Beitzke, D., Rasul, S., Wadsak, W., Mitterhauser, M., Nolz, R., Stelzmueller, M., Loewe, C., Hacker, M., Funk, Stephanie, Kermer, Josephine, Dogangüzel, Serkan, von Knobelsdorff-Brenkenhoff, Florian, Schulz-Menger, Jeanette, Kolker, Shimon, Weisz, Giora, Bogot, Naama, Halpern, Irit Hadas, Wolak, Arik, Rutz, Tobias, Ginami, Giulia, Piccini, Davide, Coppo, Simone, Vincenti, Gabriella, Stuber, Matthias, Schwitter, Jürg, Safdar, Komal S, Gao, Xuexin, Ambach, Stephanie, Taylor, Michal D, Moore, Ryan, Taylor, Robin J, Toro-Salazar, Olga, Jeffries, John L, Bartone, Cheryl, Raman, Subha V, Mazur, Wojciech, Valente, F., Rodriguez-Palomares, J.F., Gutierrez, L., Pineda, V., Agliano, B., Galian, L., Teixido, G., Gonzalez-Alujas, M.T., Evangelista, A., Garcia-Dorado, D., Murdoch, R., Gandy, S., Nicholas, R., Houston, G., Martin, P., Muir, J., Matthew, S., Ramkumar, P. Guntur-, Cavin, I., Macaione, F., Barison, A., Pescetelli, I., Pali, F., Pizzino, F., Terrizzi, A., Di Lisi, D., Novo, G., Todiere, G., Assennato, P., Novo, S., Aquaro, G.D., Dastidar, Amardeep Ghosh, McAlindon, Elisa, Rodrigues, Jonathan, Baritussio, Anna, Scatteia, Alessandra, De Garate, Estefania, Benny Lawton, Chris, Erdei, Tamas, Szantho, Gergely, Hamilton, Mark, Bucciarelli-Ducci, Chiara, Pontone, Gianluca, Andreini, Daniele, Rota, Cristina, Guglielmo, Marco, Mushtaq, Saima, Baggiano, Andrea, Beltrama, Virginia, Solbiati, Anna, Guaricci, Andrea I., Pepi, Mauro, Grigoratos, Chrysanthos, Bratis, Konstantinos, Henningson, Markus, Dell'Omodarme, Matteo, Puntmann, Valentina O., Nagel, Eike, Meloni, Antonella, Giunta, Nicola, Giuliano, Pietro, Neri, Maria Giovanna, Restaino, Gennaro, Renne, Stefania, Quota, Alessandra, Positano, Vincenzo, De Marchi, Daniele, Pepe, Alessia, Pedrotti, Patrizia, Campadello, Paola, Masciocco, Gabriella, Facchetti, Rita, Milazzo, Angela, Quattrocchi, Giuseppina, Giannattasio, Cristina, Frigerio, Maria, Roghi, Alberto, Rimoldi, Ornella, De Garate, Estefania, Ghosh Dastidar, Amardeep, Baritussio, Anna, Scatteia, Alessandra, Amadu, Antonio, Venuti, Giuseppe, Rodrigues, Jonathan C., Bucciarelli-Ducci, Chiara, Careri, Giulia, Castelvecchio, Serenella, Camporeale, Antonia, Secchi, Francesco, Menicanti, Lorenzo, Lombardi, Massimo, Kockova, R., Sedlacek, K., Wichterle, D., Sikula, V., Tintera, J., Sukupova, L., Kautznerova, D., Segetova, M., Praveckova, A., Langova, R., Kryze, L., El-Husseini, W., Kautzner, J., Oebel, S., Dinov, B., Arya, A., Hilbert, S., Sommer, P., Bollmann, A., Hindricks, G., Paetsch, I., Jahnke, C., Nazir, Sheraz A., Greenwood, John P., Shetye, Abhishek, Khan, Jamal N., Singh, Anvesha, Kanagala, Prathap, Swarbrick, Daniel, Gulsin, Gaurav, Graham-Brown, Matthew, Gershlick, Anthony, McCann, Gerry P., Grigoratos, Chrysanthos, Liga, Riccardo, Bennatti, Elena, Barison, Andrea, Todiere, Giancarlo, Aquaro, Giovanni Donato, Dell'Omodarme, Matteo, Lombardi, Massimo, Emdin, Michele, Masci, Pier Giorgio, Barison, A, Ortalda, A, Todiere, G, Grigoratos, C, Vergaro, G, Mirizzi, G, Martini, N, De Marchi, D, Keilberg, P, Passino, C, Aquaro, GD, Emdin, M, Swoboda, Peter P, McDiarmid, Adam K, Erhayiem, Bara, Fent, Graham J, Dobson, Laura E, Garg, Pankaj, Musa, Tarique A, Foley, James R, Page, Stephen P, Greenwood, John P, Plein, Sven, Bulluck, Heerajnarain, Rosmini, Stefania, Abdel-Gadir, Amna, Bhuva, Anish, Treibel, Thomas A, White, Steven K, Fontana, Marianna, Ramlall, Manish, Hamarneh, Ashraf, Sirker, Alex, Herrey, Anna, Manisty, Charlotte, Yellon, Derek M, Kellman, Peter, Moon, James C, Hausenloy, Derek J, Broncano, J., Luna, A., Noguerol, T. Martin –, Caro, P., Toro-Cebada, R., Gonzalez, J. Sanchez –, Desroche, L.M., Milleron, O., Safar, B., Lavie-Badie, Y., Millischer, D., Abtan, J., Jondeau, G., Bermejo, Zorba Blázquez, Cuesta, Emilio, Rosillo, Sandra O., Guzmán, Gabriela, Pinilla, Inmaculada, González, Óscar, Caro, Juan, Ponz, Inés, López, Teresa, Refoyo, Elena, Kozor, Rebecca, Nordin, Sabrina, Treibel, Thomas A, Rosmini, Stefania, Castelleti, Silvia, Fontana, Marianna, Captur, Gabriella, Steeds, Rick, Baig, Shanat, Manisty, Charlotte, Grieve, Stuart M, Figtree, Gemma A, Moon, James C, Dastidar, Amardeep Ghosh, Rodrigues, Jonathan, De Garate, Estefania, Singhal, Priyanka, McAlindon, Elisa, Baritussio, Anna, Scatteia, Alessandra, Erdei, Tamas, Strange, Julian, Nightingale, Angus, Baumbach, Andreas, Johnson, Tom, Delgado, Victoria, Bucciarelli-Ducci, Chiara, Lapinskas, Tomas, Bucius, Paulius, Fedaravicius, Augustinas P., Urbonaite, Laura, Stabinskaite, Agnieta, Zaliunas, Remigijus, Elisabetta, Chiodi, Teresa, Cannizzaro Maria, Daniele, De Falco Alfano, Righi, Riccardo, Zerbini, Michela, Vincenzo, Positano, Cittanti, Corrado, Giganti, Melchiore, Giorgio, Benea, Grigoratos, Chrysanthos, Genovesi, Dario, Giorgetti, Assuero, Chiappino, Sara, Barison, Andrea, Vergaro, Giuseppe, Todiere, Giancarlo, Emdin, Michele, Marzullo, Paolo, Aquaro, Giovanni Donato, Ladeiras-Lopes, Ricardo, Turin-Moreira, Henrique, Bettencourt, Nuno, Fontes-Carvalho, Ricardo, Sampaio, Francisco, Ambale-Venkatesh, Bharath, Wu, Colin, Liu, Kiang, Bertoni, Alain, Ouyang, Pamela, Bluemke, David, Lima, João, Fent, GJ., Garg, P., Dobson, LE., Musa, TA., Foley, JF., Haaf, P., Greenwood, JP., Plein, S., Swoboda, PP., Abdul Rahman, E., Ismail, JR., Najme Khir, R., Lim, CW., Chua, N., Ibrahim, ZO., Zainal Abidin, HA., Mohd Arshad, MK., Kasim, SS., Rodrigues, Jonathan, Rooms, Ben, Hyde, Katie, Rohan, Stephen, Dastidar, Amardeep Ghosh, Hamilton, Mark, Bucciarelli-Ducci, Chiara, Nightingale, Angus, Paton, Julian, Manghat, Nathan, MacIver, David, Gibelli, Giuseppe, Demolli, Walter, Russo, Alessandra, Minoia, Chiara, Biasi, Salvatore, Mkrtchyan, Naira, Eltschkner, Christin, Christian, Meierhofer, Ewert, Peter, Martinoff, Stefan, Stern, Heiko, Fratz, Sohrab, Valinoti, Maddalena, Fabbri, Claudio, Mantovan, Roberto, Severi, Stefano, Corsi, Cristiana, Nyktari, E., Vassiliou, V., Arzanauskaite, M., Izgi, C., Lam, W., Prasad, S., Reindl, Martin, Reinstadler, Sebastian Johannes, Feistritzer, Hans-Josef, Klug, Gert, Mair, Johannes, Mayr, Agnes, Jaschke, Werner, Franz, Wolfgang-Michael, Metzler, Bernhard, Arnhold, K., Muehlberg, F., Fritschi, S., Funk, S., Prothmann, M., von Knobelsdorff-Brenkenhoff, F., Schulz-Menger, J., Lakhani, Zeeshan S. A., Mohan, B., karthik, G A., Raj, Vimal, Weir-McCall, Jonathan, Cassidy, Deirdre B, Belch, Jill JF, Gandy, Stephen J, Houston, Graeme, Lambert, Matthew A, Littleford, Roberta, Rowland, Janice, Struthers, Allan D, Khan, Faisel, Camaioni, Claudia, Salel, Marjorie, Hennig, Alexia, Corneloup, Olivier, Montaudon, Michel, Laurent, Francois, Cochet, Hubert, Kan, Rachel, Erhayiem, Bara, McDiarmid, Adam K., Garg, Pankaj, Dobson, Laura E., Musa, Tarique A., Ripley, David, Ajjan, Ramzi, Greenwood, John P., Plein, Sven, Swoboda, Peter P., Reinstadler, Sebastian J., Fuernau, Georg, Eitel, Charlotte, de Waha, Suzanne, Desch, Steffen, Metzler, Bernhard, Schuler, Gerhard, Thiele, Holger, Eitel, Ingo, Feistritzer, Hans-Josef, Reinstadler, Sebastian Johannes, Klug, Gert, Reindl, Martin, Mair, Johannes, Mayr, Agnes, Franz, Wolfgang-Michael, Metzler, Bernhard, Feistritzer, Hans-Josef, Klug, Gert, Reinstadler, Sebastian Johannes, Reindl, Martin, Mayr, Agnes, Franz, Wolfgang-Michael, Metzler, Bernhard, Festa, P., Cadoni, A., D'andrea, C., Costa, S., Keilberg, P., Lunardini, A., Ali, L. Ait, Ali, L. Ait, Aquaro, GD., Peritore, G., Ricci, F., De Marchi, D., Passino, C., Festa, P., Martínez, A. Tercero, Cuartero, J. Navarro, Soriano, J.G. Córdoba, Núñez, S. Calero, de Galarreta, T. Cros Ruiz, García, M. Villar, Page, J.C. Gallego, López, J.C. García, Ruiz, M. 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- Abstract
Objectives: Myocardial fibrosis in noninfarcted myocardium is emerging as a principal phenotype of vulnerability to adverse events such as mortality and hospitalization for heart failure (HHF), but its optimal noninvasive measurement remains uncertain despite consistently robust histologic validation data for extracellular volume fraction (ECV). We therefore compared ECV, native T1, post contrast T1, the gadolinium contrast partition coefficient (lambda), and the presence of nonischemic scar in their associations with mortality and HHF outcomes. Method: To quantify of myocardial fibrosis, we performed T1 mapping (MOLLI) in basal and mid short axis slices with cardiovascular magnetic resonance (CMR) before contrast and 12-30 minutes post contrast bolus in 1185 consecutive patients without amyloidosis, hypertrophic or stress cardiomyopathy. We assessed associations with outcomes using Kaplan-Meier plots and chi square values from univariable Cox regression models. All standard T1 mapping parameters were obtained: native and post contrast myocardial T1, the partition coefficient lambda, and ECV. ECV = (1-hematocrit) · [ΔR1myocardium]/[ΔR1bloodpool], where R1 = 1/T1 Late gadolinium enhancement imaging with phase sensitive reconstruction identified nonischemic scar. Results: Over a median of 1.7 years, 111 individuals experienced events after CMR: 55 HHF events and 74 deaths. ECV yielded better separation of Kaplan-Meier curves in a dose dependent fashion (Figure) and also stronger associations with the combined endpoint of death or HHF. The ECV chi square (77.3, p < 0.001) was at least twice as large as the Native T1 chi square (37.5, p < 0.001), the lambda chi square (34.8, p < 0.001) and nonischemic scar (chi square = 20.5, p<0.001). Post-contrast T1 was not associated with outcomes, even when adjusting further for time after contrast bolus, renal function, and patient weight (chi square <3, p >0.10). Conclusion: Analogous to histologic previously published validation data, quantitative ECV myocardial fibrosis measures associated with outcomes far stronger than other surrogate measures outcome measures such as native T1, post contrast T1 and nonischemic scar on LGE images. These data suggest that ECV is the noninvasive metric of choice to measure myocardial fibrosis. Figure. Kaplan-Meier Plots for T1 mapping parameters.
- Published
- 2016
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24. Abstracts
- Author
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Elliott, PM, Moon, JC, Pepe, A, Meloni, A, Gulino, L, Rossi, G, Paci, C, Spasisno, A, keilberg, P, Restaino, G, Resta, MC, Positano, V, lombardi, M, Reiter, U, Reiter, G, Kovacs, G, Schmidt, A, Olschewski, H, Fuchsjäger, M, Macmillan, A, Dabir, D, Rogers, T, Monaghan, M, Nagel, E, Puntmann, V, Semaan, E, Spottiswoode, B, Freed, B, Carr, M, Wasielewski, M, Fortney-Campione, K, Shah, S, Carr, J, Markl, M, Collins, J, Sung, YM, Hinojar, R, Ucar, EA, Dabir, D, Voigt, T, Gaddum, N, Schaeffter, T, Nagel, E, Puntmann, VO, Dabir, D, Rogers, T, Ucar, EA, Kidambi, A, Plein, S, Gebker, R, Schnackenburg, B, Voigt, T, Schaeffter, T, Nagel, E, Puntmann, VO, McAlindon, E, Bucciarelli-Ducci, C, Sado, D, Maestrini, V, Piechnik, S, Porter, J, Yamamura, J, Fischer, R, Moon, J, Symons, R, Doulaptsis, C, Masci, P.G, Goetschalckx, K, Dymarkowski, S, Janssens, S, Bogaert, J, Yalin, K, Golcuk, E, Ozer, CS, Buyukbayrak, H, Yilmaz, R, Dursun, M, Bilge, AK, Adalet, K, Reinstadler, SJ, Klug, G, Feistritzer, HJ, 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E, Mushtaq, S, Caiani, EG, Pepi, M, El ghannudi, S, Nghiem, A, Germain, P, Jeung, M-J, Roy, C, Gangi, A, Nucifora, G, Muser, D, Masci, PG, Barison, A, Piccoli, G, Rebellato, L, Puppato, M, Gasparini, D, Lombardi, M, Proclemer, A, Nucifora, G, Muser, D, Masci, PG, Barison, A, Piccoli, G, Rebellato, L, Puppato, M, Gasparini, D, Lombardi, M, Proclemer, A, Pöyhönen, P, Kivistö, S, Holmströn, M, Hänninen, H, Thorning, C, Bickelhaupt, S, Kampmann, C, Wentz, KU, Widmer, U, Juli, CF, Miszalski-Jamka, K, Klys, J, Glowacki, J, Kijas, M, Miszalski-Jamka, T, Adamczyk, T, Kwiecinski, R, Bogucka-Czapska, J, Ozaist, M, Mazur, W, Kluczewska, E, Kalarus, Z, Kukulski, T, Karakus, G, Marzluf, B, Bonderman, D, Tufaro, C, Pfaffenberger, S, Babyev, J, Maurer, G, Mascherbauer, J, Kockova, R, Tintera, J, Kautznerova, D, Cerna, D, Sedlacek, K, Kryze, L, El-Husseini, W, Sikula, V, Segetova, M, Kautzner, J, Vasconcelos, M, Lebreiro, A, Martins, E, Cardoso, JS, Madureira, AJ, Ramos, I, Maciel, MJ, Florian, A, Ludwig, A, Rösch, S, Sechtem, U, Yilmaz, A, Monmeneu, J.V, López-Lereu, M.P, Bonanad, C, Sanchis, J, Chaustre, F, Merlos, P, Valero, E, Bodí, V, Chorro, F.J, Yalin, K, Golcuk, E, Ozer, CS, Buyukbayrak, H, Yilmaz, R, Dursun, M, Bilge, AK, Adalet, K, Klug, G, Reinstadler, SJ, Feistritzer, HJ, Mayr, A, Riegler, N, Schocke, M, Esterhammer, R, Kremser, C, Pachinger, O, Metzler, B, Siddiqi, N, Cameron, D, Neil, C, Jagpal, B, Singh, S, Schwarz, K, Papadopoulou, S, Frenneaux, MP, Dawson, D, Robbers, LFHJ, Eerenberg, ES, Teunissen, PFA, Jansen, MF, Hollander, MR, Horrevoets, AJG, Knaapen, P, Nijveldt, R, Levi, MM, van Rossum, AC, Niessen, HWM, Marcu, CB, Beek, AM, van Royen, N, Everaars, H, Robbers, LFHJ, Nijveldt, R, Beek, AM, Teunissen, PFA, Hirsch, A, van Royen, N, Zijlstra, F, Piek, JJ, van Rossum, AC, Goitein, O, Grupper, A, Hamdan, A, Eshet, Y, Beigel, R, Medvedofsky, D, Herscovici, R, Konen, E, Hod, H, Matetzky, S, Cadenas, R, Iniesta, AM, Refoyo, E, Antorrena, I, Guzman, G, Cuesta, E, Salvador, O, López, T, Moreno, M, López-Sendon, JL, Alam, SR, Spath, N, Richards, J, Dweck, M, Shah, A, Lang, N, Semple, S, MacGillivray, T, Mckillop, G, Mirsadraee, S, Pessotto, R, Zamvar, V, Newby, DE, Henriksen, P, Reiter, G, Reiter, U, Kovacs, G, Olschewski, H, Fuchsjäger, M, Ahmad, S, Raza, U, Malik, A, Sun, JP, Eisner, R, Mazur, W, ODonnell, R, Positano, V, Meloni, A, Santarelli, MF, Landini, L, Tassi, C, Grimaldi, S, Gulino, L, De Marchi, D, Chiodi, E, Renne, S, Lombardi, M, Pepe, A, Wu, L, Germans, T, Güçlü, A, Allaart, CP, van Rossum, AC, Kalisz, K, Lehenbauer, K, Katz, D, Bi, X, Cordts, M, Guetter, C, Jolly, M-P, Freed, B, Shah, S, Markl, M, Flukiger, J, Carr, J, Collins, J, Osiak, A, Tyrankiewicz, U, Jablonska, M, Jasinski, K, Jochym, PT, Chlopicki), S, Skorka, T, Kalisz, K, Semaan, E, Katz, D, Bi, X, Cordts, M, Guetter, C, Jolly, MP, Freed, B, Flukiger, J, Lee, D, Kansal, P, Shah, S, Markl, M, Carr, J, Collins, J, Groarke, JD, Shah, RV, Waller, AH, Abbasi, SA, Kwong, RY, Blankstein, R, Steigner, M, Chin, CWL, Semple, S, Malley, T, White, A, Prasad, S, Newby, DE, Dweck, M, Pepe, A, Meloni, A, Lai, ME, Vaquer, S, Gulino, L, De Marchi, D, Cuccia, L, Midiri, M, Vallone, A, Positano, V, Lombardi, M, Pedrotti, P, Milazzo, A, Quattrocchi, G, Roghi, A, Rimoldi, O, Barison, A, De Marchi, D, Masci, P, Milanesi, M, Aquaro, GD, Keilberg, P, Positano, V, Lombardi, M, Positano, Vincenzo, Barison, Andrea, Pugliese, Nicola Riccardo, Masci, Piergiorgio, Del Franco, Annamaria, Aquaro, Giovanni Donato, Landini, Luigi, Lombardi, Massimo, Dieringer, MA, Deimling, M, Fuchs, K, Winter, L, Kraus, O, Knobelsdorff-Brenkenhoff, FV, Schulz-Menger, J, Niendorf, T, Hinojar, R, Ucar, EA, DCruz, D, Sangle, S, Dabir, D, Voigt, T, Gaddum, N, Schaeffter, T, Nagel, E, Puntmann, VO, Sung, YM, Pontone, G, Andreini, D, Bertella, E, Mushtaq, S, Gripari, P, Cortinovis, S, Loguercio, M, Baggiano, A, Conte, E, Pepi, M, El ghannudi, S, Hop, O, Germain, P, Jeung, M-J, De Cesare, A, Roy, C, Gangi, A, Barone-Rochette, G, Pierard, S, Seldrum, S, De Meester de Ravensteen, C, Melchior, J, Maes, F, Pouleur, A-C, Vancraeynest, D, Pasquet, A, Vanoverschelde, J-L, L Gerber, B, Bekele, S, Singh, A, Khan, JN, Nazir, SA, Kanagala, P, McCann, GP, Singh, A, Steadman, CD, Bekele, S, Khan, JN, Nazir, SA, Kanagala, P, McCann, GP, Paelinck, BP, Vandendriessche, T, De Bock, D, De Maeyer, C, Parizel, PM, Christiaan, J, Trauzeddel, RF, Gelsinger, C, Butter, C, Barker, A, Markl, M, Schulz-Menger, J, von Knobelsdorff, F, Florian, A, Schäufele, T, Ludwig, A, Rösch, S, Wenzelburger, I, Yilmaz, A, Sechtem, U, López-Lereu, M.P, Bonanad, C, Monmeneu, J.V, Sanchís, J, Estornell, J, Igual, B, Maceira, A, Chorro, F.J, Focardi, M, Cameli, M, Bennati, E, Massoni, A, Solari, M, Carbone, F, Banchi, B, Mondillo, S, Miia, H, Kirsi, L, Helena, H, Tiina, H, Jyri, L, Pauli, P, Sari, K, Schumm, J, Greulich, S, Grün, S, Ong, P, Klingel, K, Kandolf, R, Sechtem, U, Mahrholdt, H, Raimondi, F, Ou, P, Boudjemline, Y, Bajolle, F, Iserin, F, Bonnet, D, Collins, J, Kalisz, K, Benefield, B, Sarnari, R, Katz, D, Bi, X, Cordts, M, Guetter, C, Jolly, M-P, Freed, B, Flukiger, J, Kansal, P, Lee, D, Shah, S, Markl, M, Carr, J, Sokolowska, B, Miszalski-Jamka, T, Szczeklik, W, Karwat, K, Miszalski-Jamka, K, Belzak, K, Mazur, W, Kereiakes, DJ, Jazwiec, P, Musial, J, Silva, G, Almeida, AG, Resende, C, Marques, JS, Silva, D, David, C, Amaro, C, Costa, P, Silva, JAP, Diogo, AN, Tsokolov, AV, Senchilo, VG, Vertelkin, AV, Hoffmann, P, Mykjåland, G, Wangberg, H, Tønnessen, T, Sjaastad, I, Nordsletten, L, Hjørnholm, U, Løset, A, Rostrup, M, Meloni, A, Gulino, L, Keilberg, P, Palazzi, G, Maddaloni, D, Ascioti, C, Missere, M, Salvatori, C, Positano, V, Lombardi, M, Pepe, A, Meloni, A, Filosa, A, Gulino, L, Pulini, S, Salvatori, C, Chiodi, E, Ascioti, C, Keilberg, P, Positano, V, Lombardi, M, Pepe, A, Meloni, A, Gulino, L, Pietrapertosa, A, Izzi, G, De Marchi, D, Valeri, G, Preziosi, P, Positano, V, Lombardi, M, Pepe, A, Meloni, A, Ruffo, GB, Keilberg, P, Gulino, L, Gerardi, C, Sallustio, G, Tudisca, C, Positano, V, Lombardi, M, Pepe, A, Greulich, S, Backes, M, Schumm, J, Grün, S, Sechtem, U, Mahrholdt, H, Dorniak, K, MSc, AS, Szurowska, E, Fijalkowski, M, Rawicz-Zegrzda, D, Dudziak, M, Raczak, G, Hamdan, A, Baker, FA, Klein, M, Di Segni, E, Goitein, O, Fibisch, G, Konen, E, Müller-Bierl, B, Tanaka, K, Buls, N, Fierens, Y, van Cauteren, T, Willekens, I, van Laere, S, Luypaert, R, de Mey, J, Muzzarelli, S, Faragasso, E, Pedrazzini, G, Sürder, D, Pasotti, E, Moccetti, T, Faletra, F, Qayyum, AA, Hasbak, P, Larsson, HB, Mathiasen, AB, Vejlstrup, NG, Kjaer, A, Kastrup, J, Moschetti, K, Favre, D, Pinget, C, Pilz, G, Petersen, S, Wagner, A, Wasserfallen, JB, Schwitter, J, Ghosh Dastidar, A, Cengarle, M, McAlindon, E, Augustine, D, Nightingale, AK, Bucciarelli-Ducci, C, Dandekar, VK, Ertel, AW, Dickens, C, Gonzalez, RC, Farzaneh-Far, A, Ripley, DP, Higgins, D, McDiarmid, AK, Bainbridge, GJ, Uddin, A, Kidambi, A, Herzog, B, Greenwood, JP, Plein, S, Khanji, M, Newton, T, Westwood, M, Sekhri, N, and Petersen, SE
- Abstract
Background-Aims: Early post-infarction pericardial injury is a common finding but its diagnosis remains elusive. Though C-reactive protein (CRP) is considered a marker of myocardial damage, reflecting myocardial inflammation at the infarcted area, we sought to assess the relationship between CRP and pericardial injury depicted by cardiovascular magnetic resonance (CMR) imaging in patients with ST elevation myocardial infarction (MI). Methods and results: 181 MI patients (84% male) were studied with CMR in the first week and at 4 months post-infarction to assess infarct characteristics, left ventricular volumes/function and pericardial injury. The latter was defined as pericardial fluid >4mm and/or enhancement on late gadolinium enhancement CMR. The CRP-value at day 2 (according to previous literature) was used for correlation with CMR and clinical parameters. Pericardial injury was noted in 87 patients, i.e. effusion (n = 30), inflammation (n = 46), both (n = 11). Patients with pericardial injury had significantly higher peak values of cardiac biomarkers (p<0.001) and higher peak CRP-values than patients with normal pericardium (median 13 vs 43 mg/dl, p<0.001). A strong correlation was found between peak CRP-values and a) left venticular ejection fraction and infarct size both at 1 week and 4 months, b) myocardial hemorrhage, microvascular obstruction (MVO) and pericardial injury at 1 week, c) cardiac biomarkers values and time to PCI. However in a multiple regression model only pericardial injury (p = 0.003) and less importantly time to PCI (p = 0.022) were the independent predictors of CRP values. Conclusion: Pericardial damage described by cardiac MRI occurs often after acute ST elevation MI. CRP-values at the acute phase of MI reflect not only inflammation at the infarcted area but even more the inflammation of the surrounding pericardial tissue.
Table 1 Comparison of baseline clinical and biochemical parameters of patients with or without evidence of early post-infarct pericardial damage on CMR Normal Group (n = 94) Pericardial injury group (n = 87) p-value Agem, years 59±11 60±12 0.48 Male, n(%) 83 (88) 69 (79) 0.10 Diabets, n(%) 12 (13) 9 (10) 0.61 Smoker, n(%) 52 (55) 44 (51) 0.52 Hyperlipidemia, n(%) 56 (60) 55 (63) 0.62 BSA m2 2.0 ± 0.2 2.0 ± 0.2 0.20 Time to PCI, min 195 (155 − 274) 223 (160 − 335) 0.20 Troponin I, μ/l 44 (19 − 92) 90 (44 − 149) >0.001 CK-MB, U/L 128 (77 − 216) 250 (143 − 443) >0.001 CRP, mg/dL 13 (7 − 28) 43 (16 − 96) >0.001 Day of peak CRP 2 (1 − 3) 2 (1 − 3) 0.39 Table 2 Significant correlations between CRP Values and corresponding CMR measurements, cardic biomarkers and clinical related parameters Varibles Spearmanscorrelations r p-value CMR parameters 1 week LV EF −0.28 >0,001 Infractsize(%ofLV) 0.40 >0,001 Microvasular obstruction 0.27 >0,001 Hemorrhage 0.33 >0,001 Size of area atrisk 0.31 >0,001 Transmurality 0.30 >0,001 Pericaldial damage 0.43 >0,001 CMR parameters 4 months LVEF −0.43 >0,001 Infarctsize(%ofLV) 0.46 >0,001 Cardiac Biomarkers Peak TnI 0.34 >0,001 Peak CK-MB 0.32 >0,001 Other Time to PCI 0,182 0,007 - Published
- 2013
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25. Is it a true left bundle branch block or not?
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Curila K, Jurak P, Chelu MG, Upadhyay G, Sedlacek K, and Osmancik P
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- Humans, Heart Conduction System, Electrocardiography, Bundle-Branch Block diagnosis, Arrhythmias, Cardiac
- Published
- 2023
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26. Targeted left ventricular lead positioning to the site of latest activation in cardiac resynchronization therapy: a systematic review and meta-analysis.
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Fyenbo DB, Bjerre HL, Frausing MHJP, Stephansen C, Sommer A, Borgquist R, Bakos Z, Glikson M, Milman A, Beinart R, Kockova R, Sedlacek K, Wichterle D, Saba S, Jain S, Shalaby A, Kronborg MB, and Nielsen JC
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- Humans, Echocardiography, Heart Ventricles diagnostic imaging, Hospitalization, Cardiac Resynchronization Therapy adverse effects, Heart Failure diagnosis, Heart Failure therapy
- Abstract
Aims: Several studies have evaluated the use of electrically- or imaging-guided left ventricular (LV) lead placement in cardiac resynchronization therapy (CRT) recipients. We aimed to assess evidence for a guided strategy that targets LV lead position to the site of latest LV activation., Methods and Results: A systematic review and meta-analysis was performed for randomized controlled trials (RCTs) until March 2023 that evaluated electrically- or imaging-guided LV lead positioning on clinical and echocardiographic outcomes. The primary endpoint was a composite of all-cause mortality and heart failure hospitalization, and secondary endpoints were quality of life, 6-min walk test (6MWT), QRS duration, LV end-systolic volume, and LV ejection fraction. We included eight RCTs that comprised 1323 patients. Six RCTs compared guided strategy (n = 638) to routine (n = 468), and two RCTs compared different guiding strategies head-to-head: electrically- (n = 111) vs. imaging-guided (n = 106). Compared to routine, a guided strategy did not significantly reduce the risk of the primary endpoint after 12-24 (RR 0.83, 95% CI 0.52-1.33) months. A guided strategy was associated with slight improvement in 6MWT distance after 6 months of follow-up of absolute 18 (95% CI 6-30) m between groups, but not in remaining secondary endpoints. None of the secondary endpoints differed between the guided strategies., Conclusion: In this study, a CRT implantation strategy that targets the latest LV activation did not improve survival or reduce heart failure hospitalizations., Competing Interests: Conflict of interest: M.H.J.P.F. has received consulting fees from Medtronic outside the submitted work. C.S. has attended European Heart Rhythm Association (EHRA) device-exam preparatory courses held by Biotronik and Boston Scientific. S.S. has received research support from Abbott and Boston Scientific and Advisory Board work from Medtronic and Boston Scientific. J.C.N. received grants from the Novo Nordisk Foundation outside this work and is executive editor of Europace. All other authors declare no conflicts of interest., (© The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology.)
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- 2023
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27. ILEEM-survey on the Heart Team approach and team training for lead extraction procedures.
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Starck CT, Bracke F, Delnoy PP, Freedman RA, Kutarski A, Gallagher M, Shoda M, Peyton R, Sohal M, Gadler F, Sedlacek K, Hartikainen J, Mazzone P, Breitenstein A, and Lever N
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- Humans, Patient Care Team, Surveys and Questionnaires, Cardiologists, Physicians
- Abstract
Background: The Heart Team approach has become an integral part of modern cardiovascular medicine. To evaluate current opinions and real-world practice among lead extraction practitioners, an online survey was created and distributed among a pool of lead extraction specialists participating in the International Lead Extraction Expert Meeting (ILEEM) 2018., Methods: The online survey consisted of 10 questions and was performed using an online survey tool (www.surveymonkey.com). The collector link was sent to 48 lead extraction experts via email., Results: A total of 43 answers were collected (89% return rate) from lead extraction experts in 16 different countries. A great majority (83.7%) of the respondents performed more than 30 lead extraction procedures per year. The most common procedural environment in this survey was the hybrid operating room (67.4%). Most procedures were performed by electrophysiologists and cardiologists (80.9%). Important additional members of the current lead extraction teams were cardiac surgeons (79.1%), anesthesiologists (95.3%) and operating room scrub nurses (76.7%). An extended Heart Team is regarded beneficial for patient care by 86.0%, with potential further members being infectious diseases specialists, intensivists and radiologists. Team training activities are performed in 48.8% of participating centers., Conclusions: This survey supports the importance of establishing lead extraction Heart Teams in specialized lead extraction centers to potentially improve patient outcomes. The concept of a core and an extended Heart Team approach in lead extraction procedures is introduced.
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- 2022
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28. Impact of His bundle pacing on right ventricular performance in patients undergoing permanent pacemaker implantation.
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Grieco D, Bressi E, Curila K, Padala SK, Sedlacek K, Kron J, Fedele E, Ionita O, Giannuzzi S, Fagagnini A, Panattoni G, De Ruvo E, Ellenbogen KA, and Calò L
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- Aged, Female, Humans, Male, Stroke Volume, Bundle of His physiopathology, Cardiac Pacing, Artificial methods, Pacemaker, Artificial, Ventricular Dysfunction, Right physiopathology, Ventricular Dysfunction, Right therapy
- Abstract
Background: His-Bundle pacing (HBP) is an emerging technique for physiological pacing. However, its effects on right ventricle (RV) performance are still unknown., Methods: We enrolled consecutive patients with an indication for pacemaker (PM) implantation to compare HBP versus RV pacing (RVP) effects on RV performance. Patients were evaluated before implantation and after 6 months by a transthoracic echocardiogram., Results: A total of 84 patients (age 75.1±7.9 years, 64% male) were enrolled, 42 patients (50%) underwent successful HBP, and 42 patients (50%) apical RVP. At follow up, we found a significant improvement in RV-FAC (Fractional Area Change)% [baseline: HBP 34 IQR (31-37) vs. RVP 33 IQR (29.7-37.2),p = .602; 6-months: HBP 37 IQR (33-39) vs. RVP 30 IQR (27.7-35), p < .0001] and RV-GLS (Global Longitudinal Strain)% [baseline: HBP -18 IQR (-20.2 to -15) vs. RVP -16 IQR (-18.7 to -14), p = .150; 6-months: HBP -20 IQR(-23 to -17) vs. RVP -13.5 IQR (-16 to -11), p < .0001] with HBP whereas RVP was associated with a significant decline in both parameters. RVP was also associated with a significant worsening of tricuspid annular plane systolic excursion (TAPSE) (p < .0001) and S wave velocity (p < .0001) at follow up. Conversely from RVP, HBP significantly improved pulmonary artery systolic pressure (PASP) [baseline: HBP 38 IQR (32-42) mmHg vs. RVP 34 IQR (31.5-37) mmHg,p = .060; 6-months: HBP 32 IQR (26-38) mmHg vs. RVP 39 IQR (36-41) mmHg, p < .0001] and tricuspid regurgitation (p = .005) irrespectively from lead position above or below the tricuspid valve., Conclusions: In patients undergoing PM implantation, HBP ensues a beneficial and protective impact on RV performance compared with RVP., (© 2021 Wiley Periodicals LLC.)
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- 2021
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29. Myocardial ketone body utilization in patients with heart failure: The impact of oral ketone ester.
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Monzo L, Sedlacek K, Hromanikova K, Tomanova L, Borlaug BA, Jabor A, Kautzner J, and Melenovsky V
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- Aged, Aged, 80 and over, Energy Metabolism drug effects, Esters administration & dosage, Fasting blood, Female, Humans, Male, Middle Aged, Heart Failure metabolism, Ketone Bodies metabolism, Myocardium metabolism
- Abstract
Aims: Upregulation of ketone body (β-hydroxybutyrate, βHB) utilization has been documented in human end-stage heart failure (HF), but is unclear if this is due to intrinsic cardiac metabolic remodeling or a HF-related catabolic state. This study sought to evaluate the maximal ketone body utilization capacity and its determinants in controls and in patients with moderate HF and reduced ejection fraction (HFrEF)., Methods and Results: 19 HFrEF patients and 9 controls underwent sampling from the arterial circulation (A) and coronary sinus (CS) to measure transmyocardial extraction of energy-providing substrates and oxygen. In a separate experiment, measurements were performed 80-min after oral administration of 25 g of ketone ester (KE, (R)-3-hydroxybutyl(R)-3-hydroxybutyrate) drink in 11 HFrEF and 6 control subjects. There were no statistically significant differences in fasting substrate levels and fractional extractions between HF and controls. Administration of KE increased βHB by 12.9-fold, revealing an increased ability to utilize ketones in HFrEF as compared to controls (fractional extraction, FE%: 52 vs 39%, p = 0.035). βHB FE% correlated directly with βHB myocardial delivery (r = 0.90), LV mass (r = 0.56), LV diameter (r = 0.65) and inversely with LV EF (-0.59) (all p < 0.05). βHB FE% positively correlated with lactate FE% (p < 0.01), but not with FFA or glucose FE%, arguing against substrate competition., Conclusions: Acute nutritional ketosis enhances βHB extraction in patients with HFrEF compared to controls, and this enhancement correlates with degree of cardiac dysfunction and remodeling. Data suggest that subclinical metabolic remodeling occurs early in HF progression. Further studies are needed to determine whether exogenous ketones may have a potential therapeutic role., Competing Interests: Declaration of competing interest None for all authors., (Copyright © 2020 Elsevier Inc. All rights reserved.)
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- 2021
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30. Clinical and Humoral Determinants of Congestion in Heart Failure: Potential Role of Adiponectin.
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Monzo L, Kotrc M, Benes J, Sedlacek K, Jurcova I, Franekova J, Jarolim P, Kautzner J, and Melenovsky V
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- Female, Humans, Male, Middle Aged, Prognosis, Risk Factors, Adiponectin blood, Heart Failure physiopathology
- Abstract
Background: Some patients with heart failure (HF) are more prone to systemic congestion than others. The goal of this study was to identify clinical and humoral factors linked to congestion and its prognostic impact in HF patients., Methods: A total of 371 advanced HF patients underwent physical examination, echocardiography, right heart catheterization, blood samplings, and Minnesota Living with HF Questionnaire. Subjects were followed-up for adverse events (death, urgent transplantation, or assist device implantation without heart transplantation)., Results: Thirty-one percent of patients were classified as prone to congestion. During a median follow-up of 1,093 days, 159 (43%) patients had an adverse event. In the Cox analysis, the congestion-prone (CP) status was associated with a 43% higher event risk. The CP status was strongly (p ˂ 0.001) associated with body weight loss, right ventricular dysfunction (RVD), dilated inferior vena cava (IVC), diuretics, and beta-blockers prescription and the majority of tested hormones in the univariate analysis. In the multivariate analysis, the only independent variables associated with the CP status were adiponectin, albumin, IVC diameter, and RVD. Adiponectin by itself was predictive of adverse events. In a multivariate model, CP status was no longer predictive of adverse events, in contrast to adiponectin., Conclusions: CP patients experienced more severe symptoms and had shorter survival. Potential role of adiponectin, a new independent predictor of CP status, should be further examined., (© 2019 The Author(s) Published by S. Karger AG, Basel.)
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- 2019
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31. Changes in Myocardial Composition and Conduction Properties in Rat Heart Failure Model Induced by Chronic Volume Overload.
- Author
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Sedmera D, Neckar J, Benes J Jr, Pospisilova J, Petrak J, Sedlacek K, and Melenovsky V
- Abstract
Volume overload leads to development of eccentric cardiac hypertrophy and heart failure. In our previous report, we have shown myocyte hypertrophy with no fibrosis and decrease in gap junctional coupling via connexin43 in a rat model of aorto-caval fistula at 21 weeks. Here we set to analyze the electrophysiological and protein expression changes in the left ventricle and correlate them with phenotypic severity based upon ventricles to body weight ratio. ECG analysis showed increased amplitude and duration of the P wave, prolongation of PR and QRS interval, ST segment elevation and decreased T wave amplitude in the fistula group. Optical mapping showed a prolongation of action potential duration in the hypertrophied hearts. Minimal conduction velocity (CV) showed a bell-shaped curve, with a significant increase in the mild cases and there was a negative correlation of both minimal and maximal CV with heart to body weight ratio. Since the CV is influenced by gap junctional coupling as well as the autonomic nervous system, we measured the amounts of tyrosine hydroxylase (TH) and choline acetyl transferase (ChAT) as a proxy for sympathetic and parasympathetic innervation, respectively. At the protein level, we confirmed a significant decrease in total and phosphorylated connexin43 that was proportional to the level of hypertrophy, and similarly decreased levels of TH and ChAT. Even at a single time-point, severity of morphological phenotype correlates with progression of molecular and electrophysiological changes, with the most hypertrophied hearts showing the most severe changes that might be related to arrhythmogenesis.
- Published
- 2016
- Full Text
- View/download PDF
32. Common genetic variants in ANK2 modulate QT interval: results from the KORA study.
- Author
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Sedlacek K, Stark K, Cunha SR, Pfeufer A, Weber S, Berger I, Perz S, Kääb S, Wichmann HE, Mohler PJ, Hengstenberg C, and Jeron A
- Subjects
- Adult, Aged, Electrocardiography, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Homozygote, Humans, Long QT Syndrome genetics, Male, Middle Aged, Regression Analysis, Ankyrins genetics, Polymorphism, Single Nucleotide
- Abstract
Background: Spatial and timely variations in QT interval, even within its normal range, may underlie susceptibility to cardiac arrhythmias and sudden cardiac death. Given its important role in cardiac electrophysiology, we hypothesized that common genetic variation in ankyrin-B gene (ANK2) might modify QT interval length., Methods and Results: The study population consisted of 1188 participants of the World Health Organizational Multinational Monitoring of Trends and Determinants in Cardiovascular Disease (WHO MONICA) general population survey Cooperative Health Research in the Region of Augsburg (KORA S3). Corrected QT interval was calculated using population specific linear regression formulas. A total of 22 single-nucleotide polymorphisms in the genomic region of ANK2 gene were genotyped using TaqMan technology. In a replication study, 6 single nucleotide polymorphisms were genotyped in 3890 individuals from a second population study (KORA S4). The rare variant of the single-nucleotide polymorphism rs6850768 (allele frequency, 0.28) significantly influenced duration of the QT interval, both in KORA S3 and KORA S4 populations. In homozygotes, the shortening of the QT interval was 3.79 ms (95% CI, 1.48 to 5.58; P=0.001 and P=0.0008 for log-additive and dominant model, respectively) in KORA S3 and 2.94 ms (95% CI, 1.11 to 4.77; P=0.001 and P=0.006 for log-additive and dominant genetic model, respectively) in KORA S4. A common 2-locus haplotype (rs11098171-rs6850768; population frequency, 28%) was associated with a QT interval difference of 2.85 ms (permutation; P=0.006) in KORA S3 and 1.23 ms (permutation; P=0.009) in KORA S4. Reverse transcription-polymerase chain reaction expression analysis of the human ANK2 5' genomic region in the human left ventricular tissue revealed 2 previously unidentified ANK2 5' exons in the proximity of the identified variants., Conclusions: Common genetic variants juxtaposed with novel exons in the distant 5' genomic region of ANK2 influence the QT interval length in the general population. These findings support the role of ankyrin-B in normal cardiac electric activity.
- Published
- 2008
- Full Text
- View/download PDF
33. Association between PPARalpha gene polymorphisms and myocardial infarction.
- Author
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Reinhard W, Stark K, Sedlacek K, Fischer M, Baessler A, Neureuther K, Weber S, Kaess B, Wiedmann S, Mitsching S, Lieb W, Erdmann J, Meisinger C, Doering A, Tolle R, Jeron A, Riegger G, and Hengstenberg C
- Subjects
- Adult, Aged, Aged, 80 and over, Anthropometry methods, Case-Control Studies, Female, Genetic Predisposition to Disease, Genotype, Haplotypes, Humans, Linkage Disequilibrium, Male, Middle Aged, Phenotype, Risk Factors, Myocardial Infarction genetics, PPAR alpha genetics, Polymorphism, Single Nucleotide
- Abstract
PPARalpha (peroxisome-proliferator-activated receptor alpha) regulates the expression of genes that are involved in lipid metabolism, tissue homoeostasis and inflammation. Consistent rodent and human studies suggest a link between PPARalpha function and cardiovascular disease, qualifying PPARalpha [PPARA in HUGO (Human Genome Organisation) gene nomenclature] as a candidate gene for coronary artery disease. In the present study, we comprehensively evaluated common genetic variations within the PPARalpha gene and assessed their association with myocardial infarction. First, we characterized the linkage disequilibrium within the PPARalpha gene in an initial case-control sample of 806 individuals from the Regensburg Myocardial Infarction Family Study using a panel of densely spaced SNPs (single nucleotide polymorphisms) across the gene. Single SNP analysis showed significant association with the disease phenotype [OR (odds ratio)=0.74, P=0.012, 95% CI (confidence interval)=0.61-0.94 for rs135551]. Moreover, we identified a protective three-marker haplotype with an association trend for myocardial infarction (OR=0.76, P=0.067, 95% CI=0.56-1.02). Subsequently, we were able to confirm the single SNP and haplotype association results in an independent second case-control cohort with 667 cases from the Regensburg Myocardial Infarction Family Study and 862 control individuals from the WHO (World Health Organization) MONICA (Monitoring of Trends and Determinants in Cardiovascular Disease) Augsburg project (OR=0.87, P=0.046, 95% CI=0.72-0.99 for rs135551 and OR=0.80, P=0.034, 95% CI=0.65-0.98 for the three-marker haplotype respectively). From these cross-sectional association results, we provide evidence that common variations in the PPARalpha gene may influence the risk of myocardial infarction in a European population.
- Published
- 2008
- Full Text
- View/download PDF
34. Common polymorphisms in the cannabinoid CB2 receptor gene (CNR2) are not associated with myocardial infarction and cardiovascular risk factors.
- Author
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Reinhard W, Stark K, Neureuther K, Sedlacek K, Fischer M, Baessler A, Weber S, Kaess B, Wiedmann S, Erdmann J, Lieb W, Jeron A, Riegger G, and Hengstenberg C
- Subjects
- Adult, Aged, Animals, Female, Genotype, Humans, Male, Middle Aged, Risk Factors, Genetic Predisposition to Disease, Myocardial Infarction genetics, Polymorphism, Single Nucleotide, Receptor, Cannabinoid, CB2 genetics
- Abstract
Myocardial infarction (MI) is a complex disease. Multiple genes and their interaction with various environmental factors influence the pathogenesis of MI that is thought to be tightly regulated by inflammatory pathways. Recent progress in genetic analysis includes the use of large-scale genome-wide association studies that have proven to be powerful tools even in the analysis of multifactorial phenotypes. However, certain genes are only sparsely represented on the available gene chips and additional candidate gene approaches are necessary. One such example is the CNR2 gene, encoding the cannabinoid receptor 2 (CB2), which has been implicated in mediating anti-inflammatory and anti-atherosclerotic effects in vivo. We therefore hypothesized that genetic variations within the CNR2 gene are associated with the development of MI or classic cardiovascular risk factors. In a large case-control study, 1,968 individuals from the German MI family study were examined with 13 single nucleotide polymorphisms (SNPs) covering CNR2 and the adjacent genes. The association of these SNPs with MI or cardiovascular risk factors, such as arterial hypertension, obesity, hypercholesterolemia and diabetes mellitus, was determined. In allelic and genotypic models, none of the SNPs showed a significant association with MI. Separate analyses for men and women revealed no gender-specific relationship between common genetic variations within the CNR2 gene and MI. Moreover, no significant association between CNR2 gene variants and common cardiovascular risk factors was observed. We therefore provide evidence in a large German population that common polymorphisms within the CNR2 gene confer no susceptibility to MI or to cardiovascular risk factors.
- Published
- 2008
35. Association of common polymorphisms in GLUT9 gene with gout but not with coronary artery disease in a large case-control study.
- Author
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Stark K, Reinhard W, Neureuther K, Wiedmann S, Sedlacek K, Baessler A, Fischer M, Weber S, Kaess B, Erdmann J, Schunkert H, and Hengstenberg C
- Subjects
- Adult, Aged, Aged, 80 and over, Case-Control Studies, Female, Genetic Predisposition to Disease, Humans, Male, Metabolic Syndrome genetics, Middle Aged, Myocardial Infarction genetics, Polymorphism, Single Nucleotide, Uric Acid blood, Coronary Artery Disease genetics, Glucose Transport Proteins, Facilitative genetics, Gout genetics, Polymorphism, Genetic
- Abstract
Background: Serum uric acid (UA) levels have recently been shown to be genetically influenced by common polymorphisms in the GLUT9 gene in two genome-wide association analyses of Italian and British populations. Elevated serum UA levels are often found in conjunction with the metabolic syndrome. Hyperuricemia is the major risk factor for gout and has been associated with increased cardiovascular morbidity and mortality. The aim of the present study was to further elucidate the association of polymorphisms in GLUT9 with gout and coronary artery disease (CAD) or myocardial infarction (MI). To test our hypotheses, we performed two large case-control association analyses of individuals from the German MI Family Study., Methods and Findings: First, 665 patients with gout and 665 healthy controls, which were carefully matched for age and gender, were genotyped for four single nucleotide polymorphisms (SNPs) within or near the GLUT9 gene. All four SNPs demonstrated highly significant association with gout. SNP rs6855911, located within intron 7 of GLUT9, showed the strongest signal with a protective effect of the minor allele with an allelic odds ratio of 0.62 (95% confidence interval 0.52-0.75; p = 3.2*10(-7)). Importantly, this finding was not influenced by adjustment for components of the metabolic syndrome or intake of diuretics. Secondly, 1,473 cases with severe CAD or MI and 1,241 healthy controls were tested for the same four GLUT9 SNPs. The analyses revealed, however, no significant association with CAD or with MI. Additional screening of genome-wide association data sets showed no signal for CAD or MI within the GLUT9 gene region., Conclusion: Thus, our results provide compelling evidence that common genetic variations within the GLUT9 gene strongly influence the risk for gout but are unlikely to have a major effect on CAD or MI in a German population.
- Published
- 2008
- Full Text
- View/download PDF
36. Lymphotoxin-alpha and galectin-2 SNPs are not associated with myocardial infarction in two different German populations.
- Author
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Sedlacek K, Neureuther K, Mueller JC, Stark K, Fischer M, Baessler A, Reinhard W, Broeckel U, Lieb W, Erdmann J, Schunkert H, Riegger G, Illig T, Meitinger T, and Hengstenberg C
- Subjects
- Aged, DNA Mutational Analysis, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Germany, Haplotypes, Humans, Male, Middle Aged, Myocardial Infarction ethnology, Polymerase Chain Reaction, White People genetics, Galectin 2 genetics, Lymphotoxin-alpha genetics, Myocardial Infarction genetics, Polymorphism, Single Nucleotide
- Abstract
Recent data provided strong evidence for the association of single nucleotide polymorphisms (SNPs) in the lymphotoxin-alpha (LTA) and galectin-2 (LGALS2) genes with myocardial infarction (MI) in a Japanese population. For populations of other genetic background, the relevance of these polymorphisms in the pathogenesis of MI remains controversial. We aimed to define the role of LTA and LGALS2 SNPs in two German MI populations with markedly different ascertainment strategies. Two different MI populations were studied. In the first population, MI patients were ascertained by a strong family history of MI (n = 1214). Controls were unrelated disease-free participants of the study (n = 1080). The second population included patients suffering from sporadic (nonfamilial) MI from the German KORA register (n = 607). The control group consisted of participants of the WHO MONICA survey in Germany (n = 1492). TaqMan assays were used to determine the genotypes of 4 SNPs in the LTA genomic region and 1 SNP in the LGALS2 gene. Single SNPs in both genomic regions as well as haplotypes in the LTA genomic region were tested for association in various models of inheritance. No association with MI could be found for any of the examined SNPs in the LTA genomic region and LGALS2 gene, or for haplotypes spanning the LTA genomic region. In two MI populations of European descent with markedly different ascertainment strategies, we were not able to identify a significant association of SNPs in the LTA genomic region or the LGALS2 gene with MI. These variants are unlikely to play a significant role in populations of European origin.
- Published
- 2007
- Full Text
- View/download PDF
37. The common Y402H variant in complement factor H gene is not associated with susceptibility to myocardial infarction and its related risk factors.
- Author
-
Stark K, Neureuther K, Sedlacek K, Hengstenberg W, Fischer M, Baessler A, Wiedmann S, Jeron A, Holmer S, Erdmann J, Schunkert H, and Hengstenberg C
- Subjects
- Adult, Aged, Aged, 80 and over, Case-Control Studies, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, Male, Middle Aged, Myocardial Infarction etiology, Prospective Studies, Risk Factors, Complement Factor H genetics, Myocardial Infarction genetics
- Abstract
Recently, the genetic variant Y402H in the CFH (complement factor H) gene was associated with an increased risk for MI (myocardial infarction) in a prospective Caucasian cohort. In another nested case-control study, however, the CFH-Y402H variant did not carry susceptibility to MI. The aim of the present study was to test for an association between the CFH-Y402H variant and MI in a large case-control sample with a familial background for CAD (coronary artery disease). A total of 2161 individuals from the German MI family study were studied by questionnaire, physical examination and biochemical analyses. MI patients (n=1188; 51.4+/-8.6 years at first MI) were recruited from families with at least two members affected by MI and/or severe CAD. Spouses, sisters-in-law and brothers-in-law respectively, without MI/CAD were included as unaffected controls (n=973; 56.9+/-9.8 years). Genotyping was performed using a TaqMan assay. The common Y402H variant in the CFH gene was not associated with classical cardiovascular risk factors (diabetes, hypercholesterolaemia, hypertension, obesity, smoking and C-reactive protein serum levels). No association was found between the CFH-Y402H variant and susceptibility to MI. Separate analyses in both men and women revealed no gender-specific influence of the gene variant on cardiovascular risk factors or MI. This investigation was unable to replicate the association between the common CFH-Y402H variant and susceptibility to MI in our large Caucasian population which is enriched for genetic factors. We conclude that the CFH-Y402H variant has no relevant risk-modifying effect in our population.
- Published
- 2007
- Full Text
- View/download PDF
38. Computer use in the health office.
- Author
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Sedlacek KK and Bergren MD
- Subjects
- Humans, Information Services, Software, Surveys and Questionnaires, United States, Management Information Systems standards, Management Information Systems statistics & numerical data, School Nursing
- Published
- 1993
39. [The metastatic prostate cancer. Effectiveness of a combination of female hormones and specific immune-stimulating therapy].
- Author
-
Gutschank S, Rothauge CF, Kraushaar J, Gutschank W, and Sedlacek KH
- Subjects
- Humans, Male, Phosphoric Monoester Hydrolases blood, Prostatic Neoplasms therapy, Estradiol Congeners therapeutic use, Immunotherapy methods, Prostatic Neoplasms secondary
- Published
- 1981
40. The effectiveness of biofeedback-assisted relaxation in modifying sickle cell crises.
- Author
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Cozzi L, Tryon WW, and Sedlacek K
- Subjects
- Adolescent, Adult, Anemia, Sickle Cell psychology, Body Temperature Regulation, Child, Combined Modality Therapy, Electromyography, Evaluation Studies as Topic, Female, Follow-Up Studies, Humans, Male, Anemia, Sickle Cell therapy, Biofeedback, Psychology, Relaxation
- Abstract
Eight outpatients with sickle cell disease received six EMG and six thermal half-hour biofeedback training sessions. Statistically significant changes in the desired directions were obtained for the following variables: (a) frontalis muscle tension, (b) digital temperature, (c) frequency of headache as a crisis symptom, (d) frequency of analgesic use, (e) perceived pain intensity, (f) frequency of self-treated crises, and (g) state anxiety. Nonsignificant changes in hospital chart data were found. A 6-month posttreatment follow-up questionnaire revealed the continued effectiveness of the training received regarding headaches and mild pains.
- Published
- 1987
- Full Text
- View/download PDF
41. Helping the asthmatic child in school.
- Author
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Sedlacek K
- Subjects
- Asthma psychology, Child, Gender Identity, Humans, Interpersonal Relations, Motor Skills, Patient Care Planning, Psychology, Child, Asthma nursing, Environment, Learning, School Nursing
- Published
- 1978
- Full Text
- View/download PDF
42. Biofeedback for Raynaud's disease.
- Author
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Sedlacek K
- Subjects
- Adult, Animals, Female, Follow-Up Studies, Humans, Biofeedback, Psychology, Raynaud Disease therapy
- Published
- 1979
- Full Text
- View/download PDF
43. Biofeedback in the treatment of blepharospasm: a case study.
- Author
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Rowan GE and Sedlacek K
- Subjects
- Blepharospasm psychology, Electromyography, Female, Haloperidol therapeutic use, Humans, Middle Aged, Psychotherapy, Biofeedback, Psychology, Blepharospasm therapy, Eyelid Diseases therapy
- Abstract
Although biofeedback has been of value in treating spastic paresis and torticollis, its effectiveness in other movement disorders is less clear. Blepharospasm, which has no definitive treatment, often has a strong psychogenic component. The authors report the use of electromyographic and temperature biofeedback in a women with blepharospasm who had responded poorly to psychotherapy. Her improvement during biofeedback treatment further elucidated psychogenic factors contributing to the disorder. At 3-months follow-up it seemed that the patient's secondary gain from the blepharospasm diminished the maximum treatment response she could have had to biofeedback.
- Published
- 1981
- Full Text
- View/download PDF
44. [Audiological findings in tick meningoencephalitis].
- Author
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SEDLACEK K and ZEMAN K
- Subjects
- Animals, Humans, Hearing, Hearing Disorders etiology, Hearing Tests, Meningoencephalitis, Ticks
- Published
- 1957
45. [Closure of tympanic perforation].
- Author
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SEDLACEK K, SIROKY A, and LANGOVA J
- Subjects
- Humans, Tympanic Membrane, Tympanic Membrane Perforation
- Published
- 1953
46. [A new method for the investigation of directional hearing in clinical practice].
- Author
-
SEDLACEK K
- Subjects
- Humans, Hearing, Hearing Tests
- Published
- 1960
47. [Hearing of compound sounds, particularly vowels].
- Author
-
SEDLACEK K
- Subjects
- Humans, Hearing, Language, Phonetics
- Published
- 1955
48. [ON MICROSURGERY IN SPONTANEOUS TYMPANOPLASTY].
- Author
-
POSPISIL A and SEDLACEK K
- Subjects
- Humans, Cholesteatoma, Connective Tissue, Ear, Middle, Granulation Tissue, Hearing Tests, Microsurgery, Otitis Media, Surgical Procedures, Operative, Tympanoplasty
- Published
- 1963
49. [AUDITORY ANALYZER FROM THE VIEWPOINT OF THE THEORY OF INFORMATION].
- Author
-
SEDLACEK K
- Subjects
- Humans, Central Nervous System, Cybernetics, Hearing, Hearing Tests, Sensory Receptor Cells
- Published
- 1964
50. [Scientific works of prof. Dr. M. Seeman].
- Author
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SEDLACEK K
- Subjects
- History, 19th Century, History, 20th Century, Phonetics
- Published
- 1952
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