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Objectives Arterial stiffness is associated with major adverse cardiovascular events. Chronic venous insufficiency (CVI) is severe form of chronic venous disease (CVD). The aim of this study is to investigate arterial stiffness by cardio-ankle vascular index (CAVI) in patients with CVI. Methods This observational and cross-sectional study involved 87 subjects with CVI and 86 healthy subjects. All subjects underwent ultrasonography examination. CAVI was measured by VaSera-1000 CAVI instrument. Results High density lipoprotein cholesterol (HDL) was significantly lower in patients with CVI than controls (46.83 ± 9.25 mg/dl vs 51.33 ± 11.13 mg/dl, p = 0.004). Body mass index (BMI) was significantly higher in CVI patients than controls (28.53 ± 4.10 kg/m2 vs 26.37 ± 5.16 kg/m2, p = 0.003). Ankle brachial index (ABI) was significantly lower in patients with CVI compared to controls (1.08 ± 0.08 vs 1.14 ± 0.11, p 7.9 had a sensitivity 64.4% and a specificity of 94.7% for predicting the presence of CVI in ROC analysis (area under curve = 0.791, 95% CI = 0.723–0.849, p Conclusion CAVI is independently increased in CVI patients. Therefore CVI may be accepted a form of vascular sclerosis and vascular system should be evaluated in continuum not isolated.

Objective: The purpose of this study was to show the association between oxidative stress and deep venous thrombosis (DVT) by determining total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) values in patients with DVT and to take precautionary measures to balance oxidative status. Methods: TOS, TAS and OSI levels in serum from 52 individuals with DVT and 45 without DVT were compared. Results: TOS and OSI levels were significantly higher in patients with DVT compared with the control group (p

Objectives This study investigated the diagnostic value of signal peptide-CUB-EGF domain-containing protein 1 (SCUBE-1) and other oxidative stress parameters in the early diagnosis of acute mesenteric ischemia, which has high mortality and morbidity if not identified and treated in the early period. Methods Thirty-six female Sprague-Dawley rats were used in this randomized, controlled study. Rats were divided into six groups: three control groups (Groups I, III, and V) and three ischemia groups (Groups II, IV, and VI). In the control groups, blood and tissue specimens were sampled at 30 minutes (Group I), 2 hours (Group III), and 6 hours (Group V), following a simple laparotomy. In the ischemia groups, the superior mesenteric artery (SMA) was ligated following laparotomy, and blood and tissue samples were sampled at 30 minutes (Group II), 2 hours (Group IV), and 6 hours (Group VI). Results When comparing the ischemia and control groups, the differences in SCUBE-1, malondialdehyde (MDA), and total antioxidant status (TAS) levels in the 30-minute period were not significant (p > 0.05); at 2 hours, SCUBE-1 levels rose rapidly, and although the desired level of significance could not be obtained with Bonferroni correction, the level was significantly higher compared to the control group at the same time interval (for SCUBE-1, Group III vs. Group IV, p = 0.006). In these periods (30 minutes and 2 hours), only total oxidative status (TOS) and oxidative stress index (OSI) values were significantly higher in the ischemia group compared to the control group (for both, p = 0.004). A pronounced rise in SCUBE-1 levels was determined with 6-hour ischemia (for SCUBE-1, Group V vs. Group VI, p = 0.004). The changes in MDA, TAS, TOS, and OSI levels were not significant (p = 0.025, p = 0.321, p = 0.006, and p = 0.037, respectively). Conclusions SCUBE-1 levels have the potential to be used as a marker of early period injury in acute mesenteric ischemia, although it is impossible to state explicitly that they can be used for early diagnosis. The same can be said for plasma MDA and TAS levels. The authors believe that TOS and OSI levels, however, can be used in early diagnosis and as an injury marker. Moreover, OSI also exhibits a medium-strong correlation with histopathologic injury. ResumenEl Valor del Peptido Senal-CUB-Dominio EGF que Contiene Proteina 1 (SCUBE-1) y los Parametros de Estres Oxidativo en el Diagnostico de la Isquemia Mesenterica Aguda Objetivos Este estudio investiga el valor diagnostico del peptido senal-CUB-dominio EGF-que contiene proteina 1 (SCUBE-1) y otros parametros de estres oxidativo en el diagnostico precoz de la isquemia mesenterica aguda, la cual tiene una alta mortalidad y morbilidad si no es identificada y tratada precozmente. Metodologia Treinta y seis ratas hembras Sprague-Dawley se utilizaron en este estudio controlado con asignacion aleatoria. Las ratas se dividieron en seis grupos: tres grupos control (Grupos I, III y V) y tres grupos de isquemia (Grupos II, IV y VI). En los grupos control, se tomaron muestras de tejido y sangre a los 30 minutos (Grupo I), las 2 horas (Grupo III) y las 6 horas (Grupo V), seguido de una laparotomia simple. En los grupos de isquemia, se ligo la arteria mesenterica superior (AMS) tras la laparotomia, y se tomaron muestras de tejido y sangre a los 30 minutos (Grupo II), 2 horas (Grupo IV) y 6 horas (Grupo VI). Resultados Cuando comparamos los grupos de isquemia y control, las diferencias a los 30 minutos en SCUBE-1, malondialdehido (MDA) y en el del estado antioxidante total (EAT) no fueron significativas (p > 0,05). A las dos horas, los niveles de SCUBE-1 se elevaron rapidamente, y aunque el nivel deseado de significacion no pudo ser obtenido con la correccion de Bonferroni, el nivel fue significativamente mayor comparado con el grupo control en el mismo intervalo de tiempo (para SCUBE-1, Grupo III vs. Grupo IV, p = 0,006). En estos periodos (30 minutos y dos horas), solo los valores del estado oxidativo total (EOT) y del indice de estres oxidativo (IEO) fueron significativamente mayores en el grupo isquemia comparado con el grupo control (para ambos, p = 0,004). Se hallo un incremento pronunciado en los niveles de SCUBE-1 a las 6 horas de la isquemia (para SCUBE-1, Grupo V vs. Grupo VI, p = 0,004). Los cambios en los valores de MDA, TAS, EOT, y IEO no fueron significativos (p = 0,025, p = 0,321, p = 0,006, y p = 0,037, respectivamente). Conclusiones Los valores de SCUBE-1 tienen la potencialidad de ser usados como un marcador de lesion precoz en la isquemia aguda mesenterica, aunque es imposible declarar explicitamente que puedan ser usados para el diagnostico precoz. Lo mismo puede decirse para los valores plasmaticos de MDA y EAT. Los autores piensan que el EOT y el IEO, sin embargo, pueden ser usados en el diagnostico precoz y como un marcador de lesion. Sin embargo, el IEO tambien exhibe una correlacion media-fuerte con la lesion histopatologica.

The aim of this study was to evaluate the oxidant-antioxidant balance in patients with abdominal aortic aneurysms (AAA). Forty-two consecutive patients with AAA and 46 control subjects were included. Total oxidant status (TOS) and total antioxidant status (TAS) levels were measured and the oxidative stress index (OSI) value determined. Serum TOS and OSI values in patients with AAA were higher than those in the controls (p2O2 equivalent/L for TOS was associated with 86% sensitivity and 83% specificity and a cut-off value of 1.77 for OSI was associated with 86% sensitivity and 81% specificity for predicting AAA. Systemic oxidative imbalance develops in patients with AAA, particularly as a result of an increase in TOS.

Backround. The aim of this study was to evaluate the changes in perioperative oxidant-antioxidant balance in ONCABG.Methods. Twenty-three patients were included in this study. Serum total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) values were assessed preoperatively, at 20 minutes after aortic clamping and at 30 minutes, 6 hours, and 48 hours after declamping (reperfusion). The patients were divided into 2 groups according to the median aortic cross clamping (XC) time: group 1 (XC time < 42 minutes) and group 2 (XC time ≥ 42 minutes).Results. TOS and OSI values of whole patients at 30 minutes after reperfusion were higher than preoperative values (P=0.045,P=0.015), while perioperative TAS levels of the patients were similar to the preoperative levels (P=0.173). XC time was correlated with TOS levels at 30 minutes after reperfusion (r=0.43,P=0.041). In group 2, TOS and OSI values at 30 minutes after reperfusion were higher than preoperative values (P=0.023,P=0.048), whereas a significant difference was not found in group 1 (P=0.601,P=0.327).Conclusions. Oxidative imbalance and increase in TOS at reperfusion in ONCABG may be associated with XC time.

Methanol is a substance possessing high toxicity even in small quantities. It may lead to intracerebral hemorrhage, blindness and death. Methanol poisoning generally takes place as result of oral ingestion, but may rarely occur through inhalation or transdermally. Persons may be exposed to methanol because of illegal alcohol beverage producers or alternative medicine providers. A 55-year-old male with methanol poisoning as a result of rubbing a self-prepared mixture of methylated spirit and aspirin on his shoulder with the aim of alleviating pain was described in this case report. Emergency physicians should remember that patients presenting with visual problems, altered awareness and impaired balance may have methanol poisoning. J. Exp. Clin. Med., 2013; 30:367-368