1. Autonomic symptoms following Zika virus infection
- Author
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Carolina Ramírez-Santana, Manuel Rojas, Yeny Acosta-Ampudia, Juan-Manuel Anaya, Yhojan Rodríguez, and Diana M. Monsalve
- Subjects
Male ,Neurology ,Autonomic symptoms ,Autonomic dysfunction ,Orthostatic intolerance ,Disease ,Zika virus ,Autonomic neuropathy ,0302 clinical medicine ,Secretomotor disease ,Middle aged ,Patient-reported outcome ,biology ,Zika Virus Infection ,Middle Aged ,Retrospective study ,Flavivirus ,COMPASS 31 ,Female ,medicine.symptom ,Bladder disease ,Human ,Adult ,medicine.medical_specialty ,Clinical article ,030231 tropical medicine ,Case control study ,Pathophysiology ,Article ,03 medical and health sciences ,Disease association ,Immunoglobulin M antibody ,Internal medicine ,medicine ,Humans ,Retrospective Studies ,Endocrine and Autonomic Systems ,business.industry ,Case-control study ,Dysautonomia ,Neutralizing antibody ,medicine.disease ,biology.organism_classification ,Immunoglobulin G antibody ,Zika fever ,Autonomic Nervous System Diseases ,Composite autonomic symptom score 31 ,Case-Control Studies ,Neurology (clinical) ,business ,Complication ,Controlled study ,030217 neurology & neurosurgery - Abstract
Purpose: To determine if autonomic symptoms are associated with previous Zika virus infection. Methods: Case–control study including 35 patients with Zika virus infection without evidence of neurological disease and 105 controls. Symptoms of autonomic dysfunction were assessed with the composite autonomic symptom scale 31 (COMPASS-31). Results: Patients with previous Zika virus infection had significantly higher COMPASS-31 score than controls regardless of age and sex (p = 0.007). The main drivers for the higher scores where orthostatic intolerance (p = 0.003), secretomotor (p = 0.04) and bladder symptoms (p less than 0.001). Conclusion: Zika virus infection is associated with autonomic dysfunction. The mechanisms remain to be elucidated. © 2018, Springer-Verlag GmbH Germany, part of Springer Nature.
- Published
- 2018
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