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1. Hepatocellular Carcinoma and Occupation in Men: A Case-Control Study

Author: Françoise Degos, Gilles Pelletier, Marie-Anne Loriot, Jean-François Ferrand, Sylvie Cénée, Pierre Laurent-Puig, Isabelle Stücker, Jean Claude Trinchet, Jean-Pierre Bronovicky, Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Bases moléculaires de la réponse aux xénobiotiques (U775 (IFR95)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service d'hépato-gastroentérologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service d'hépatologie, Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Hôpital Bicêtre, Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, Secretariat, U754, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Hôpital Beaujon [AP-HP], Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Bases moléculaires de la réponse aux xénobiotiques ( U775 (IFR95) ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Assistance publique - Hôpitaux de Paris (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP)-Université Paris Diderot - Paris 7 ( UPD7 ) -Hôpital Beaujon, and Université Paris-Sud - Paris 11 ( UP11 ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Bicêtre
Subjects: Adult, Male, medicine.medical_specialty, Carcinoma, Hepatocellular, Time Factors, Metal machining, Professional activity, Interviews as Topic, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Occupational Exposure, Internal medicine, Epidemiology, Humans, Medicine, Occupations, Aged, business.industry, Liver Neoplasms, Public Health, Environmental and Occupational Health, Case-control study, [ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie, Odds ratio, Middle Aged, medicine.disease, Control subjects, 030210 environmental & occupational health, 3. Good health, Surgery, Occupational Diseases, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Case-Control Studies, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, business
Abstract: International audience; OBJECTIVE:: The principal objective of this work was to evaluate the association between the risk of hepatocellular carcinoma (HCC) and various occupations. METHODS:: This case-control study, conducted during 2000 to 2003 in four French hospitals, included 125 men younger than 75 years with incident HCC and 142 men as control subjects. RESULTS:: An association with HCC was observed for machinery fitters and machine assemblers (odds ratio [OR] = 4.4 [1.0-19.0], eight exposed cases and three exposed controls). A higher percentage of cases than controls were metal machinists (OR = 2.2 [0.8-5.8], 14 exposed cases and 10 exposed controls), although the difference was not statistically significant. These associations were strongest for subjects with duration of employment greater than 20 years. CONCLUSIONS:: Our findings suggest an association between metal machining jobs and hepatocellular carcinoma, although we cannot rule out the possibility that it was observed by chance.
Published: 2008
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2. Birth-related characteristics, congenital malformation, maternal reproductive history and neuroblastoma: The ESCALE study (SFCE)

Author: Anne Auvrignon, Frédéric Bernard, Jean Michon, Christophe Bergeron, Justyna Kanold, Dominique Valteau-Couanet, Brigitte Lacour, Caroline Thomas, Hervé Rubie, Denis Hémon, Caroline Munzer, Carole Coze, Florence Menegaux, Jacqueline Clavel, Jean Pierre Vannier, Secretariat, U754, Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Registre National des Tumeurs Solides de l'Enfant (RNTSE), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Cancéropôle du Grand Est, Institut Gustave Roussy (IGR), Conception synthèse et étude d'antitumoraux, Institut Curie [Paris]-Centre National de la Recherche Scientifique (CNRS), Hôpital de la Timone [CHU - APHM] (TIMONE), Centre Léon Bérard [Lyon], Service d'hématologie-immunologie-oncologie pédiatrique [CHU Trousseau], Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Hôpital Arnaud de Villeneuve [CHRU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Hôpital mère et enfant, CHU Rouen, Normandie Université (NU), Hôpital Hôtel-Dieu de Clermont-Ferrand, CHU Clermont-Ferrand, Registre National des Hémopathies malignes de l'Enfant (RNHE), Institut de Veille Sanitaire (INVS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital des Enfants, and CHU Toulouse [Toulouse]
Subjects: Male, Cancer Research, Pediatrics, Neuroblastoma, 0302 clinical medicine, Pregnancy, Surveys and Questionnaires, risk factors, Birth Weight, Medicine, 030212 general & internal medicine, Child, Reproductive History, education.field_of_study, Gestational age, 3. Good health, Birth order, Oncology, Child, Preschool, 030220 oncology & carcinogenesis, epidemiology, Female, France, Maternal Age, Adult, medicine.medical_specialty, Adolescent, Birth weight, Population, Gestational Age, Article, Congenital Abnormalities, 03 medical and health sciences, Humans, Medical history, education, congenital anomalies, business.industry, Infant, Odds ratio, medicine.disease, Socioeconomic Factors, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Case-Control Studies, Etiology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Birth Order, business
Abstract: International audience; Since neuroblastoma occurs very early in children's lives, it has been hypothesized that pre- and perinatal factors may play a role in its etiology. This study investigated the role of birth characteristics, congenital malformation and maternal reproductive history in neuroblastoma. The data used were generated by the national population-based case-control study, ESCALE, conducted in France in 2003-2004. The mothers of 191 neuroblastoma cases and 1,681 controls, frequency-matched by age and gender, were interviewed by telephone, using a standardized questionnaire, on several factors including pregnancy, medical history, lifestyle, childhood medical conditions and exposures. A positive association between congenital malformation and all neuroblastoma cases was observed [Odds ratio (OR) = 2.2, 95% confidence interval (95% CI): 1.1-4.5]. Congenital malformations were highly associated to neuroblastoma in children aged less than 1 year (OR = 16.8, 95% CI: 3.1-90), while no association was observed in children aged 1 year or more (OR = 1.0, 95% CI: 0.3-2.9). A negative association with a maternal history of spontaneous abortions was also found (OR = 0.6, 95% CI: 0.4-0.9). The results strongly support the hypothesis that congenital anomalies may be associated with neuroblastoma, particularly in infant (less than 1 year of age). (c) 2007 Wiley-Liss, Inc.
Published: 2007
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3. Maternal alcohol and coffee drinking, parental smoking and childhood leukaemia: a French population-based case?control study

Author: Jacqueline Clavel, Denis Hémon, M. Ripert, Florence Menegaux, Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Secretariat, U754
Subjects: Male, Pediatrics, medicine.medical_specialty, Adolescent, Alcohol Drinking, Epidemiology, Population, Mothers, Population based, maternal alcohol, 03 medical and health sciences, 0302 clinical medicine, childhood leukaemia, Pregnancy, Risk Factors, Caffeine, medicine, Humans, 030212 general & internal medicine, Child, education, Coffee drinking, education.field_of_study, parental smoking, business.industry, Smoking, Case-control study, Infant, Precursor Cell Lymphoblastic Leukemia-Lymphoma, medicine.disease, 3. Good health, Maternal alcohol, Childhood leukaemia, Leukemia, Myeloid, Acute, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Case-Control Studies, Child, Preschool, 030220 oncology & carcinogenesis, Pediatrics, Perinatology and Child Health, Etiology, Central Nervous System Stimulants, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, maternal caffeine, business, Demography
Abstract: We investigated the role of maternal alcohol and coffee drinking during pregnancy and that of parental smoking in the aetiology of childhood leukaemia. A French, population-based, case-control study was conducted, comparing 472 [407 acute lymphoblastic leukaemia (ALL) and 62 acute myeloblastic leukaemia] cases of childhood acute leukaemia (AL) and 567 population controls, frequency-matched with cases on age, gender and region of residence. Both case and control mothers filled in a comprehensive self-administered standardised questionnaire, eliciting detailed data on maternal alcohol and coffee consumption during pregnancy and parental smoking before, during and after pregnancy. Maternal alcohol consumption of more than 1 drink per day was related to ALL (OR = 2.8 [95% CI 1.8, 5.9]). While maternal coffee consumption was not significantly related to AL (OR = 1.4 [95% CI 0.9, 2.3]), highest intake of coffee (more than 3 cups per day) during pregnancy was associated with AL in children whose mothers were non-smokers (OR = 1.9 [95% CI 1.0, 3.5]). No association with parental smoking, either maternal or paternal, was observed with AL. The present results suggest a possible role of the highest consumption of alcohol by the mother during pregnancy in the aetiology of childhood AL.
Published: 2007
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4. History of infections and vaccinations and risk of lymphoid neoplasms: does influenza immunization reduce the risk?

Author: Xavier Troussard, Jacqueline Clavel, Laurent Orsi, Pierre Fenaux, F. Huguet, Gerald Marit, Noel-Jean Milpied, Denis Hémon, Christian Berthou, Michel Leporrier, Alain Monnereau, Pierre Soubeyran, Secretariat, U754, Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Plateforme de génétique moléculaire des cancers d'Aquitaine, Institut Bergonié [Bordeaux], UNICANCER-UNICANCER, Laboratoire d'Hématologie Biologique [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Service d'Hématologie, Hôpital Morvan [Brest], Service d'hématologie clinique [Avicenne], Université Paris 13 (UP13)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service des maladies du sang, CHU Bordeaux [Bordeaux]-Hôpital Haut-Lévêque [CHU Bordeaux], CHU Bordeaux [Bordeaux]-Groupe Hospitalier Sud, Service Hématologie - IUCT-Oncopole [CHU Toulouse], Pôle Biologie [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Pôle IUCT [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Service d'Hématologie Hôtel Dieu Nantes, Hôtel Dieu, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris 13 (UP13)-Hôpital Avicenne [AP-HP], Laboratoire d'Hématologie [Purpan], Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse], CHU Bordeaux [Bordeaux]-Groupe Hospitalier Sud-Hôpital Haut-Lévêque [CHU Bordeaux], and CHU Bordeaux [Bordeaux]
Subjects: Cancer Research, Lymphoma, chemical and pharmacologic phenomena, Infections, Influenza immunization, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Humans, Medicine, Lymphoid neoplasms, 030212 general & internal medicine, ComputingMilieux_MISCELLANEOUS, Leukemia, business.industry, Vaccination, virus diseases, Hematology, biochemical phenomena, metabolism, and nutrition, Virology, 3. Good health, stomatognathic diseases, Oncology, Influenza Vaccines, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, 030220 oncology & carcinogenesis, Immunology, bacteria, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Risk Reduction Behavior
Abstract: History of infections and vaccinations and risk of lymphoid neoplasms: does influenza immunization reduce the risk?
Published: 2007
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5. Progress in the epidemiological understanding of gene–environment interactions in major diseases: cancer

Author: Jacqueline Clavel, Secretariat, U754, Epidémiologie environnementale des cancers, and Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: medicine.medical_specialty, Multivariate analysis, Transcription, Genetic, Genomics, Disease, Computational biology, Environment, Biology, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, Neoplasms, Epidemiology of cancer, Epidemiology, medicine, Humans, Genetic Predisposition to Disease, Gene, Genotyping, 030304 developmental biology, Genetics, 0303 health sciences, Polymorphism, Genetic, Models, Genetic, General Immunology and Microbiology, Smoking, Cancer, General Medicine, medicine.disease, 3. Good health, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, 030220 oncology & carcinogenesis, Carcinogens, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, General Agricultural and Biological Sciences
Abstract: Cancer epidemiology has undergone marked development since the 1950s. One of the most spectacular and specific contributions was the demonstration of the massive effect of smoking on the occurrence of lung, larynx, and bladder cancer. Major chemical, physical, and biological carcinogenic agents have been identified in the working environment and in the overall environment. The chain of events from environmental exposures to cancer requires hundreds of polymorphic genes coding for proteins involved in the transport and metabolism of xenobiotics, or in repair, or in an immune or inflammatory response. The multifactorial and multistage characteristics of cancer create the theoretical conditions for statistical interactions that have been exceptionally detected. Over the last two decades, a considerable mass of data has been generated, mostly addressing the interactions between smoking and xenobiotic-metabolizing enzymes in smoking-related cancers. They were sometimes considered disappointing, but they actually brought a lot of information and raised many methodological issues. In parallel, the number of polymorphisms that can be considered candidate per function increased so much that multiple testing has become a major issue, and genome wide-screening approaches have more and more gained in interest. Facing the resulting complexity, some instruments are being set up: our studies are now equipped with carefully sampled biological collections, high-throughput genotyping systems are becoming available, work on statistical methodologies is ongoing, bioinformatics databases are growing larger and access to them is becoming simpler; international consortiums are being organized. The roles of environmental and genetic factors are being jointly elucidated. The basic rules of epidemiology, which are demanding with respect to sampling, with respect to the histological and molecular criteria for cancer classification, with respect to the evaluation of environmental exposures, their timeframes, quantification and covariables, with respect to study size and with respect to the rigor of multivariate analyses, are more pertinent than ever before. To cite this article: J. Clavel, C. R. Biologies 330 (2007).
Published: 2007
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6. Time trends and geographic variations for thyroid cancer in New Caledonia, a very high incidence area (1985–1999)

Author: Laurent Orsi, Thérèse Truong, Yannick Rougier, Denis Hémon, Dominique Dubourdieu, Chantal Guihenneuc-Jouyaux, Pascal Guénel, Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Institut Pasteur de Nouvelle-Calédonie, Réseau International des Instituts Pasteur ( RIIP ) -Institut Pasteur de Nouvelle-Calédonie, Laboratoire d'Anatomie et Cytopathologie, Mathématiques Appliquées à Paris 5 ( MAP5 - UMR 8145 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National des Sciences Mathématiques et de leurs Interactions-Centre National de la Recherche Scientifique ( CNRS ), Secretariat, U754, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Réseau International des Instituts Pasteur (RIIP), Laboratoire d'Anatomie et Cytopathologie [CHT Gaston-Bourret], Mathématiques Appliquées Paris 5 (MAP5 - UMR 8145), and Université Paris Descartes - Paris 5 (UPD5)-Institut National des Sciences Mathématiques et de leurs Interactions (INSMI)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Adult, Male, Cancer Research, Pathology, medicine.medical_specialty, Adolescent, Epidemiology, 030209 endocrinology & metabolism, 03 medical and health sciences, Age Distribution, 0302 clinical medicine, New Caledonia, Carcinoma, Humans, Medicine, Thyroid Neoplasms, Thyroid cancer, Aged, Aged, 80 and over, business.industry, Time trends, Histological type, Incidence, Incidence (epidemiology), Thyroid, Public Health, Environmental and Occupational Health, [ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie, Middle Aged, medicine.disease, Carcinoma, Papillary, 3. Good health, medicine.anatomical_structure, Oncology, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, 030220 oncology & carcinogenesis, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, High incidence, business, Developed country, Demography
Abstract: Thyroid cancer incidence in New Caledonia is the highest reported in the world and is approximately 10-fold higher than in most developed countries. We describe the incidence patterns in this country according to histological and sociodemographic characteristics to give clues about potential etiologic factors. Another objective is to see whether the incidence figures are related to enhanced detection of small size carcinomas. The study included all 498 cases of thyroid cancer diagnosed in 1985-1999. Pathology reports were systematically reviewed to determine the histological type of the tumor and the size of the cancerous nodules. The incidence of carcinomas < or =10 mm was taken as an indicator of enhanced detection due to improved screening procedures. The age-standardized incidence rates in 1985-1999 were exceptionally high in Melanesian women (71.4/100,000) and men (10.4/100,000). The incidence increased three-fold in women from 1995 onwards. The increase in incidence was more striking for papillary carcinomas < or =10 mm than for large size carcinomas, but an increased incidence of carcinomas >10 mm was also observed among women. The analysis by municipality of residence in Melanesian women showed that the incidence was twice as high in 1995-1999 in the Loyalty Islands as in the rest of the country. The sharp increase of thyroid cancer incidence in 1985-1999 in New Caledonia was partly related to enhanced detection of small size carcinomas. The elevated incidence of thyroid cancers, as well as the ethnic and geographic disparities, may result from common environmental or lifestyle risk factors that need to be identified.
Published: 2007
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7. Lung Cancer Attributable to Indoor Radon Exposure in France: Impact of the Risk Models and Uncertainty Analysis

Author: S. Billon, Denis Hémon, Olivier Catelinois, Pierre Verger, Agnès Rogel, Dominique Laurier, Margot Tirmarche, Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), ORS PACA, and Secretariat, U754
Subjects: Male, Lung Neoplasms, Time Factors, Health, Toxicology and Mutagenesis, Air pollution, medicine.disease_cause, MESH: Risk Assessment, MESH: Occupational Exposure, Radon exposure, Radium, 0302 clinical medicine, Medicine, 030212 general & internal medicine, uncertainty analysis, MESH: Aged, education.field_of_study, MESH: Middle Aged, Smoking, risk assessment, radon, Middle Aged, MESH: Mining, MESH: Case-Control Studies, 3. Good health, 030220 oncology & carcinogenesis, Air Pollution, Indoor, Female, France, Risk assessment, Adult, MESH: Smoking, Population, chemistry.chemical_element, Radon, Models, Biological, Mining, 03 medical and health sciences, Environmental health, Occupational Exposure, Humans, Lung cancer, education, Aged, MESH: Humans, business.industry, Research, MESH: Time Factors, Public Health, Environmental and Occupational Health, MESH: Models, Biological, MESH: Adult, medicine.disease, MESH: Male, MESH: Lung Neoplasms, respiratory tract diseases, MESH: France, radiation, lung cancer, chemistry, 13. Climate action, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Case-Control Studies, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Radiation protection, MESH: Air Pollution, Indoor, business, MESH: Radon, MESH: Female
Abstract: Radon is a chemically inert radioactive gas of natural origin, produced by the disintegration of uranium and radium located in the earth’s crust. Radon exposure, at various levels, is omnipresent for the general public. Radon inhalation is the main source of exposure to radioactivity for most people throughout the world [National Research Council’s (NRC) Committee on the Biological Effects of Ionizing Radiation (BEIR) 1999; National Council for Radiation Protection and Measurements 1984a, 1984b; U.S. Environmental Protection Agency (EPA) 2003; United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) 2000]. Most inhaled radon is rapidly exhaled, but the inhaled decay products—readily deposited in the lung epithelium—irradiate sensitive cells in the airways and thereby enhance the risk of lung cancer. In 1988, the International Agency for Research on Cancer (IARC) declared radon to be carcinogenic for humans (lung cancer) and classified as a group 1 carcinogen (IARC 1988), based on the results of experimental animal and epidemiologic studies, in particular among uranium miners. In 1988, the available results came from studies of high exposure levels. Extrapolation of this risk to the general population, who are exposed to lower levels in residential settings, raised numerous questions. In recent years, the average annual exposure of uranium miners has fallen to levels similar to the concentrations inhaled in some homes, and discussion today focuses on the transposition of the risk from occupational to general populations. Miners are almost all adult males, exposed in conditions different from residential exposure: they perform substantial amounts of heavy labor in an atmosphere polluted by dust and fumes. Several case-control studies of residential radon have tested the validity of this risk transposition in the past decade (Auvinen et al. 1996; Kreienbrock et al. 2001; Letourneau et al. 1994; Schoenberg et al. 1990), but lack of statistical power prevented most of them from showing a significant risk. To deal with this problem, several joint analyses have been conducted in recent years. They report a significant lung cancer risk after domestic radon exposure (Darby et al. 2005; Krewski et al. 2005; Lubin 2003). Scientists have used all of these data to assess the lung cancer risk associated with indoor radon. The principal risk assessments come from the United States, the United Kingdom, and Canada (BEIR 1999; Darby et al. 2005; Krewski et al. 2005). These studies have two principal methodologic problems. The first is related to the choice of the exposure–response relation and its use in the context of general population exposure. Past risk assessment studies generally used exposure–response relations derived from miners’ cohorts as recommended by BEIR (1990, 1999). The second methodologic problem involves the role of the uncertainty analysis in the risk assessment process. Uncertainty analysis is an essential step that is too seldom performed. The aim of this study was to assess the lung cancer risk associated with indoor radon exposure in France on the basis of French measurements and the major epidemiologic results available. Specifically, we applied several different exposure–response relations obtained from miners’ cohorts and from joint analyses of residential case-control studies to estimate the number of lung cancer deaths in 1999 that may have been associated with residential radon exposure. The analysis considers the variability of indoor radon exposure in France and allows the quantification of uncertainties related to each of the exposure–response relations.
Published: 2006
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8. Uncertainty and Sensitivity Analysis in Assessment of the Thyroid Cancer Risk Related to Chernobyl Fallout in Eastern France

Author: Pierre Verger, Marianne Ignasiak, Dominique Laurier, Marc Colonna, Denis Hémon, Margot Tirmarche, Olivier Catelinois, Agnès Rogel, Secretariat, U754, Institut de Radioprotection et de Sûreté Nucléaire (IRSN), ORS PACA, Registre des Cancers de l'Isère, CHU Grenoble, Recherches épidémiologiques et statistiques sur l'environnement et la santé., and Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Radioactive Fallout, MESH: Neoplasms, Radiation-Induced, Neoplasms, Radiation-Induced, Time Factors, MESH: Registries, MESH: Risk Assessment, Cohort Studies, MESH: Child, Radiation, Ionizing, thyroid cancer, Medicine, Lack of knowledge, MESH: Incidence, Registries, Child, Safety, Risk, Reliability and Quality, uncertainty analysis, MESH: Cohort Studies, Thyroid cancer, MESH: Risk, Incidence, Incidence (epidemiology), MESH: Infant, Newborn, Thyroid, MESH: Infant, Pooled analysis, medicine.anatomical_structure, MESH: Thyroid Neoplasms, Child, Preschool, MESH: Power Plants, France, ionizing radiation, Radioactive Hazard Release, Ukraine, Risk assessment, Cohort study, Risk, MESH: Radiation Dosage, endocrine system, Adolescent, MESH: Ukraine, MESH: Radiation, Ionizing, Radiation Dosage, Risk Assessment, Sensitivity and Specificity, Physiology (medical), Humans, MESH: Accidents, Radiation, Thyroid Neoplasms, MESH: Adolescent, MESH: Humans, business.industry, MESH: Time Factors, MESH: Child, Preschool, Infant, Newborn, Infant, Cancer, MESH: Radioactive Fallout, medicine.disease, MESH: Sensitivity and Specificity, MESH: France, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Nuclear medicine, Power Plants, Demography
Abstract: International audience; The increase in the thyroid cancer incidence in France observed over the last 20 years has raised public concern about its association with the 1986 nuclear power plant accident at Chernobyl. At the request of French authorities, a first study sought to quantify the possible risk of thyroid cancer associated with the Chernobyl fallout in France. This study suffered from two limitations. The first involved the lack of knowledge of spontaneous thyroid cancer incidence rates (in the absence of exposure), which was especially necessary to take their trends into account for projections over time; the second was the failure to consider the uncertainties. The aim of this article is to enhance the initial thyroid cancer risk assessment for the period 1991-2007 in the area of France most exposed to the fallout (i.e., eastern France) and thereby mitigate these limitations. We consider the changes over time in the incidence of spontaneous thyroid cancer and conduct both uncertainty and sensitivity analyses. The number of spontaneous thyroid cancers was estimated from French cancer registries on the basis of two scenarios: one with a constant incidence, the other using the trend observed. Thyroid doses were estimated from all available data about contamination in France from Chernobyl fallout. Results from a 1995 pooled analysis published by Ron et al. were used to determine the dose-response relation. Depending on the scenario, the number of spontaneous thyroid cancer cases ranges from 894 (90% CI: 869-920) to 1,716 (90% CI: 1,691-1,741). The number of excess thyroid cancer cases predicted ranges from 5 (90% UI: 1-15) to 63 (90% UI: 12-180). All of the assumptions underlying the thyroid cancer risk assessment are discussed.
Published: 2005
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9. PROJECTING THE TIME TREND OF THYROID CANCERS: ITS IMPACT ON ASSESSMENT OF RADIATION-INDUCED CANCER RISKS

Author: Denis Hémon, Marc Colonna, Pierre Verger, Olivier Catelinois, Agnès Rogel, Margot Tirmarche, Institut de Radioprotection et de Sûreté Nucléaire (IRSN), ORS PACA, Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Secretariat, U754
Subjects: Male, MESH: Neoplasms, Radiation-Induced, Neoplasms, Radiation-Induced, Time Factors, Epidemiology, Health, Toxicology and Mutagenesis, MESH: Risk Assessment, 0302 clinical medicine, MESH: Child, Child, Thyroid cancer, education.field_of_study, Incidence (epidemiology), MESH: Infant, Newborn, Thyroid, MESH: Infant, 3. Good health, medicine.anatomical_structure, MESH: Thyroid Neoplasms, Child, Preschool, 030220 oncology & carcinogenesis, Female, Risk assessment, medicine.medical_specialty, Adolescent, Population, 030209 endocrinology & metabolism, Risk Assessment, 03 medical and health sciences, medicine, Humans, Radiology, Nuclear Medicine and imaging, Thyroid Neoplasms, education, MESH: Adolescent, MESH: Humans, business.industry, MESH: Time Factors, MESH: Child, Preschool, Infant, Newborn, Infant, Cancer, medicine.disease, MESH: Male, Surgery, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Radiation-induced cancer, business, MESH: Female, Demography
Abstract: International audience; The incidence of thyroid cancer, which may be induced by ionizing radiation, has been rising in most Western countries for more than 20 years. In France, public worry about this increase and its possible connection with the fallout from Chernobyl led the government to ask for an evaluation of the health impact of this accident and an assessment of the feasibility of an epidemiological study. These requests raise two methodological questions: Which risk model should be used to relate exposure to risk? What is known about the spontaneous incidence rate of thyroid cancers? This article analyzes the impact of the time trend in the spontaneous incidence of thyroid cancers over the past 20 years in France when evaluating the risk of radiation-induced cancer. Age-period-cohort models were used to model the trend of spontaneous incidence from 1978 through 1997 and then to apply two scenarios for projections up to 2007: one with a constant incidence, the other using the trend observed over the past 20 years. Then the risk was assessed for a hypothetical population of 30,000 children aged 0 to 15 y, exposed to a hypothetical 0.1 Gy thyroid dose. The analysis shows that consideration of the trend instead of a constant spontaneous incidence can yield substantial differences in the risk estimates for thyroid cancer.
Published: 2004
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10. Childhood leukaemia incidence below the age of 5 years near French nuclear power plants

Author: Denis Hémon, Jacqueline Clavel, Dominique Laurier, Radiobiologie et épidémiologie (DRPH/SRBE), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Secretariat, U754, and Service de RadioBiologie et d'Epidémiologie (IRSN/DRPH/SRBE)
Subjects: Range (biology), MESH: Leukemia, Radiation-Induced, Article, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, hemic and lymphatic diseases, Humans, Medicine, MESH: Incidence, Waste Management and Disposal, Leukemia, Radiation-Induced, MESH: Humans, business.industry, Incidence, Incidence (epidemiology), MESH: Infant, Newborn, MESH: Child, Preschool, Infant, Newborn, Public Health, Environmental and Occupational Health, Absolute risk reduction, Infant, food and beverages, General Medicine, Nuclear power, MESH: Infant, Infant newborn, 3. Good health, Childhood leukaemia, MESH: France, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Child, Preschool, 030220 oncology & carcinogenesis, MESH: Power Plants, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, business, Power Plants, Demography
Abstract: A recent study indicated an excess risk of leukaemia among children under the age of 5 years living in the vicinity of nuclear power plants in Germany. We present herein results about the incidence of childhood leukaemia in the vicinity of nuclear power plants in France for the same age range. These results don’t indicate an excess risk of leukaemia in young children living near French nuclear power plants. Results currently available in France do not corroborate the observation of the German study.
Published: 2008
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11. Increased frequency of hematopoietic malignancies in relatives of patients with lymphoid neoplasms: a French case-control study

Author: Sara Villeneuve, Denis Hémon, Michel Leporrier, Alain Monnereau, Pierre Soubeyran, Xavier Troussard, Noel Milpied, Laurent Orsi, Gerald Marit, Pierre Fenaux, Françoise Huguet, Jacqueline Clavel, Christian Berthou, Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Plateforme de génétique moléculaire des cancers d'Aquitaine, Institut Bergonié [Bordeaux], UNICANCER-UNICANCER, Registre des hémopathies malignes de la Gironde, Hôpital Morvan, Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Service d'hématologie clinique [Avicenne], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris 13 (UP13)-Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Bordeaux Segalen - Bordeaux 2, Laboratoire d'Hématologie [Purpan], Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse], Laboratoire d'Hématologie Biologique [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Registre des hémopathies malignes de Basse-Normandie [CHU Caen], CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Secretariat, U754, Université Paris 13 (UP13)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], Service Hématologie - IUCT-Oncopole [CHU Toulouse], Pôle Biologie [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Pôle IUCT [CHU Toulouse], and Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)
Subjects: Oncology, Adult, Male, Cancer Research, medicine.medical_specialty, Lymphoma, aetiology, Lymphoproliferative disorders, Article, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, hemic and lymphatic diseases, medicine, Humans, Family, Multiple myeloma, 030304 developmental biology, Aged, 0303 health sciences, Leukemia, business.industry, Incidence (epidemiology), lymphoid neoplasm, Incidence, Case-control study, Middle Aged, medicine.disease, Lymphoproliferative Disorders, 3. Good health, Non-Hodgkin's lymphoma, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, 030220 oncology & carcinogenesis, Case-Control Studies, Immunology, Etiology, epidemiology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Female, business, Multiple Myeloma
Abstract: International audience; Lymphoid neoplasms (LNs), including non-Hodgkin's lymphoma (NHL), Hodgkin's lymphoma (HL), lymphoproliferative syndrome (LPS) and multiple myeloma (MM), are among the most frequent cancers ( approximately 17,000 new cases per year in France), after those related to smoking. LNs were investigated using the data from the ENGELA study. ENGELA is a multicenter hospital-based case-control study that was carried out in France over the period September 2000-December 2004. In all, 822 cases (397 NHL, 149 LH, 168 SLP and 108 MM) and 752 controls were included and described 5,481 and 5,188 first-degree relatives, respectively. A positive association with a familial history of hematopoietic cancer was observed for LN (OR = 1.7 [1.0-2.8]) overall and for LPS (OR = 3.2 [1.4-6.8]). The associations with HL (OR = 10.4 [2.0-53.8]) and NHL (OR = 2.4 [1.0-5.9]) were stronger for men. The associations were also stronger when the disease had been diagnosed before the relatives were aged 45 years. The results mainly support the involvement of genetic factors and suggest that at least some of those factors may be sex-linked. However, the slight overrepresentation of affected spouses among the cases might also support the responsibility of environmental factors.
Published: 2008
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12. Occupational exposure to pesticides and lymphoid neoplasms among men: results of a French case-control study

Author: Françoise Huguet, Laurene Delabre, Philippe Delval, Pierre Fenaux, Alain Monnereau, Christian Berthou, Pierre Soubeyran, Xavier Troussard, Jacqueline Clavel, Gerald Marit, Noel Milpied, Michel Leporrier, Laurent Orsi, Denis Hémon, Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Occupational Health Department, French institute of Public Health, Plateforme de génétique moléculaire des cancers d'Aquitaine, Institut Bergonié [Bordeaux], UNICANCER-UNICANCER, Registre des hémopathies malignes de la Gironde, ACTA, Institut National de la Recherche Agronomique (INRA), Service d'Hématologie, Hôpital Morvan [Brest], Service d'hématologie clinique [Avicenne], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris 13 (UP13)-Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service des maladies du sang, CHU Bordeaux [Bordeaux]-Groupe Hospitalier Sud-Hôpital Haut-Lévêque [CHU Bordeaux], CHU Bordeaux [Bordeaux], Laboratoire d'Hématologie [Purpan], Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse], Laboratoire d'Hématologie Biologique [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Institut Bergonié - CRLCC Bordeaux, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris 13 (UP13)-Hôpital Avicenne, CHU Bordeaux [Bordeaux]-Hôpital Haut-Lévêque [CHU Bordeaux], CHU Bordeaux [Bordeaux]-Groupe Hospitalier Sud, Secretariat, U754, Université Paris 13 (UP13)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], Service Hématologie - IUCT-Oncopole [CHU Toulouse], Pôle Biologie [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Pôle IUCT [CHU Toulouse], and Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)
Subjects: Male, Pathology, Insecticides, Lymphoma, MESH: Multiple Myeloma, MESH: Occupational Exposure, 0302 clinical medicine, MESH: Lymphoma, Non-Hodgkin, Epidemiology, occupation, Young adult, MESH: Aged, Leukemia, Hairy Cell, MESH: Middle Aged, MESH: Employment, Lymphoma, Non-Hodgkin, Middle Aged, 030210 environmental & occupational health, MESH: Case-Control Studies, Hodgkin Disease, MESH: Hodgkin Disease, 3. Good health, Occupational Diseases, MESH: Young Adult, 030220 oncology & carcinogenesis, epidemiology, France, Multiple Myeloma, MESH: Occupational Diseases, Adult, Employment, medicine.medical_specialty, Adolescent, MESH: Fungicides, Industrial, farming, Article, Occupational medicine, 03 medical and health sciences, Young Adult, Internal medicine, Occupational Exposure, medicine, Humans, MESH: Pesticides, Pesticides, Adverse effect, MESH: Herbicides, Aged, MESH: Adolescent, MESH: Humans, business.industry, Herbicides, Public Health, Environmental and Occupational Health, Case-control study, MESH: Adult, Odds ratio, Pesticide, medicine.disease, MESH: Male, MESH: Insecticides, Fungicides, Industrial, MESH: France, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Leukemia, Hairy Cell, Case-Control Studies, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Lymphoma
Abstract: International audience; OBJECTIVES: Investigating the relationship between occupational exposure to pesticides and the risk of lymphoid neoplasms (LNs) in men. METHODS: A hospital-based case-control study was conducted in six centres in France between 2000 and 2004. The cases were incident cases with a diagnosis of LN aged 18-75 years. During the same period, controls of the same age and sex as the cases were recruited in the same hospital, mainly in the orthopaedic and rheumatological departments. Exposures to pesticides were evaluated through specific interviews and case-by-case expert reviews. Four hundred and ninety-one cases (244 cases of non-Hodgkin's lymphoma (NHL), 87 of Hodgkin's lymphoma (HL), 104 of lymphoproliferative syndromes (LPSs) and 56 of multiple myeloma (MM) cases) and 456 controls were included in the analyses. The odds ratios (ORs) and 95% CI were estimated using unconditional logistic regressions. RESULTS: Positive associations between HL and occupational exposure to triazole fungicides and urea herbicides were observed (OR = 8.4 (2.2 to 32.4), 10.8 (2.4 to 48.1), respectively). Exposure to insecticides, fungicides and herbicides were linked to a threefold increase in MM risk (OR = 2.8 (1.2 to 6.5), 3.2 (1.4 to 7.2), 2.9 (1.3 to 6.5)). For LPS subtypes, associations restricted to hairy-cell leukaemia (HCL) were evidenced for exposure to organochlorine insecticides, phenoxy herbicides and triazine herbicides (OR = 4.9 (1.1 to 21.2), 4.1 (1.1 to 15.5), 5.1 (1.4 to 19.3)), although based on small numbers. Lastly, despite the increased ORs for organochlorine and organophosphate insecticides, carbamate fungicides and triazine herbicides, no significant associations were evidenced for NHL. CONCLUSIONS: The results, based on case-by-case expert review of occupation-specific questionnaires, support the hypothesis that occupational pesticide exposures may be involved in HL, MM and HCL and do not rule out a role in NHL. The analyses identified specific pesticides that deserve further investigation and the findings were consistent with those of previous studies.
Published: 2008
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13. Descriptive epidemiology of childhood Langerhans cell histiocytosis in France, 2000-2004

Author: Mohamed Barkaoui, Stéphanie Bellec, Jacqueline Clavel, Aurélie Guyot-Goubin, Caroline Thomas, Jean Donadieu, Registre National des Hémopathies malignes de l'Enfant (RNHE), Institut de Veille Sanitaire (INVS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'hématologie-immunologie-oncologie pédiatrique [CHU Trousseau], Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Groupe d'Etude des Histiocytoses (GEH), Groupe d'Etude des Histiocytoses, Pôle cancérologie, and Secretariat, U754
Subjects: Pediatrics, medicine.medical_specialty, Adolescent, Population, Disease, 03 medical and health sciences, Sex Factors, 0302 clinical medicine, Langerhans cell histiocytosis, children, Humans, Medicine, Registries, 030212 general & internal medicine, Child, education, Survival rate, Childhood Langerhans Cell Histiocytosis, education.field_of_study, business.industry, Incidence, Incidence (epidemiology), Age Factors, Infant, Hematology, medicine.disease, 3. Good health, Survival Rate, Clinical trial, Histiocytosis, Langerhans-Cell, Histiocytosis, Oncology, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Child, Preschool, 030220 oncology & carcinogenesis, Pediatrics, Perinatology and Child Health, description, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, Epidemiologic Methods, business
Abstract: Introduction Childhood Langerhans cell histiocytosis (LCH) is a rare and poorly understood multisystemic disease. The French National Registry of Childhood Hematopoietic Malignancies (NRCH) has recorded LCH cases of all subtypes since 2000. The present study describes the data on LCH collected on a national scale over a 5-year period. Materials and Methods The cases were children aged less than 15 years, diagnosed with LCH of any type between 2000 and 2004, and residing in mainland France at the time of diagnosis. Completeness was evaluated by capture–recapture after cross-checking against the database compiled by the French Langerhans Cell Histiocytosis Study Group. Results Two hundred fifty-eight cases of LCH were registered. The completeness of the NRCH was estimated to be 97%. The annual incidence rate was 4.6/106 children aged less than 15 years and the sex ratio was 1.2. Bone and skin were the most commonly involved organs at diagnosis. The incidence rate decreased with age from 15.3/106 before 1 year to 2.0/106 after 10 years. The disease was mainly unifocal (2.6/106) and rarely disseminated (0.6/106), but disseminated forms predominated in infants. The overall 2-year survival rate was 99% (95%CI: [97; 100]). About 30% of the LCH cases were enrolled in a clinical trial at first onset. No case was treated by radiotherapy. Conclusion This study evidenced the main features of LCH incidence in the overall population and was consistent with previous studies. The NRCH thus appears to be a very promising tool for further elucidation of LCH. Pediatr Blood Cancer 2008;51:71–75. © 2008 Wiley-Liss, Inc.
Published: 2008
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14. [Clinical presentation and epidemiology of childhood Langerhans cell Histiocytosis]

Author: Donadieu, Jean, Guyot-Goubin, Aurélie, Clavel, Jacqueline, Thomas, Caroline, Service d'hématologie-immunologie-oncologie pédiatrique [CHU Trousseau], Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), and Secretariat, U754
Subjects: Europe, Histiocytosis, Langerhans-Cell, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Incidence, histiocytose langerhansienne, Humans, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, Child, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2008
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15. UV radiation exposure, skin type and lymphoid malignancies: results of a French case-control study

Author: Pierre Soubeyran, Françoise Huguet, Denis Hémon, Laurent Orsi, Xavier Troussard, Gerald Marit, Laure Grandin, Jacqueline Clavel, Christian Berthou, Pierre Fenaux, Alain Monnereau, Noel Milpied, Michel Leporrier, Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire d'Hématologie Biologique [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Plateforme de génétique moléculaire des cancers d'Aquitaine, Institut Bergonié [Bordeaux], UNICANCER-UNICANCER, Hôpital Morvan, Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Service d'hématologie clinique [Avicenne], Université Paris 13 (UP13)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service des maladies du sang, CHU Bordeaux [Bordeaux]-Hôpital Haut-Lévêque [CHU Bordeaux], CHU Bordeaux [Bordeaux]-Groupe Hospitalier Sud, Service Hématologie - IUCT-Oncopole [CHU Toulouse], Pôle Biologie [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Pôle IUCT [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Service d'Hématologie Hôtel Dieu Nantes, Hôtel Dieu, Secretariat, U754, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris 13 (UP13)-Hôpital Avicenne [AP-HP], Laboratoire d'Hématologie [Purpan], Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse], CHU Bordeaux [Bordeaux]-Groupe Hospitalier Sud-Hôpital Haut-Lévêque [CHU Bordeaux], and CHU Bordeaux [Bordeaux]
Subjects: Adult, Male, Oncology, Cancer Research, medicine.medical_specialty, Skin type, Ultraviolet Rays, Lymphoproliferative disorders, Skin Pigmentation, Article, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, UV Radiation Exposure, medicine, Humans, UV radiation exposure, 030212 general & internal medicine, Hair Color, Multiple myeloma, Aged, Hematology, Eye Color, business.industry, Case-control study, Middle Aged, medicine.disease, Lymphoproliferative Disorders, 3. Good health, Lymphoma, skin type and lymphoma, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Case-Control Studies, 030220 oncology & carcinogenesis, Immunology, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, business
Abstract: International audience; OBJECTIVES: Investigating the relationship between skin type, UV exposure, and lymphoid malignancies (LM). METHODS: We conducted a hospital-based case-control study in France, including 813 incident cases of non-Hodgkin's lymphoma (NHL), Hodgkin's lymphoma (HL), lymphoproliferative syndrome (LPS) or multiple myeloma and 748 controls. RESULTS: Positive associations between HL and blond/red hair (OR = 1.8 [0.8-3.8]), very fair/fair skin (OR = 1.6 [1.0-2.5]) were observed. High propensity to burn was associated with HL (OR = 1.5 [1.0-2.2]) and LPS (OR = 1.4 [1.0-2.1]). Poor ability to tan was significantly associated with HL (OR = 1.7 [1.0-2.8]). Having light hair with high propensity to burn was associated with NHL (OR = 1.5 [0.9-2.5]) and significantly with HL (OR = 3.4 [1.4-8.4]). Having dark hair with high propensity to burn was significantly associated with LPS (OR = 1.5 [1.0-2.2]). The associations with HL and NHL were significant for men only, with significant interactions. Outdoors activities since leaving school or in the last decade were not related to LM. Only an almost negative trend was observed. Prior exposure to artificial UV was not associated with LM. CONCLUSION: These results suggest a positive association between the most reactive and palest skin types and NHL or HL in men and do not rule out a slight negative relationship between UV exposure and LM.
Published: 2008
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16. Has the impact of heat waves on mortality changed in France since the European heat wave of summer 2003? A study of the 2006 heat wave

Author: F Laurent, Denis Hémon, Anne Fouillet, Grégoire Rey, E. Jougla, Pierre Bessemoulin, Vérène Wagner, Karine Laaidi, A Le Tertre, Philippe Frayssinet, P. Empereur-Bissonnet, P. de Crouy-Chanel, Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Veille Sanitaire (INVS), Météo-France, Météo France, Centre d'épidémiologie sur les causes médicales de décès (CépiDc), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre national de recherches météorologiques (CNRM), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Secretariat, U754, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS)
Subjects: Male, Hot Temperature, 010504 meteorology & atmospheric sciences, Epidemiology, Population, Poison control, 010501 environmental sciences, Dog days, Heat Stress Disorders, 01 natural sciences, Models, Biological, symbols.namesake, Humans, Poisson regression, education, 0105 earth and related environmental sciences, Aged, Excess mortality, education.field_of_study, Models, Statistical, Temperature, General Medicine, Heat wave, Middle Aged, mortality, excess mortality, 13. Climate action, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, symbols, Environmental science, preventive measures, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, Seasons, Demography, heat waves
Abstract: International audience; BACKGROUND: In July 2006, a lasting and severe heat wave occurred in Western Europe. Since the 2003 heat wave, several preventive measures and an alert system aiming at reducing the risks related to high temperatures have been set up in France by the health authorities and institutions. In order to evaluate the effectiveness of those measures, the observed excess mortality during the 2006 heat wave was compared to the expected excess mortality. METHODS: A Poisson regression model relating the daily fluctuations in summer temperature and mortality in France from 1975 to 2003 was used to estimate the daily expected number of deaths over the period 2004-2006 as a function of the observed temperatures. RESULTS: During the 2006 heat wave (from 11 to 28 July), about 2065 excess deaths occurred in France. Considering the observed temperatures and with the hypothesis that heat-related mortality had not changed since 2003, 6452 excess deaths were predicted for the period. The observed mortality during the 2006 heat wave was thus markedly less than the expected mortality ( approximately 4400 less deaths). CONCLUSIONS: The excess mortality during the 2006 heat wave, which was markedly lower than that predicted by the model, may be interpreted as a decrease in the population's vulnerability to heat, together with, since 2003, increased awareness of the risk related to extreme temperatures, preventive measures and the set-up of the warning system.
Published: 2008
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17. Birth characteristics and childhood malignant central nervous sytem tumors: the ESCALE study (French Society for Childhood Cancer)

Author: François Doz, Pascal Chastagner, Florence Menegaux, Anne-Isabelle Bertozzi, Didier Frappaz, Nathalie Mallol-Mesnard, Brigitte Lacour, Olivier Hartmann, Jacqueline Clavel, Denis Hémon, Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Registre National des Tumeurs Solides de l'Enfant (RNTSE), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Cancéropôle du Grand Est, Département de Pédiatrie, Institut Gustave Roussy (IGR), Centre Léon Bérard [Lyon], Institut Curie [Paris], Hôpital des Enfants, CHU Toulouse [Toulouse], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Registre National des Hémopathies malignes de l'Enfant (RNHE), Institut de Veille Sanitaire (INVS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Secretariat, U754, and Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)
Subjects: Male, Risk, Cancer Research, medicine.medical_specialty, Pediatrics, childhood CNS tumor, Adolescent, Reproductive Techniques, Assisted, Birth weight, Population, birth characteristics, Gestational Age, Reproductive technology, Paternal Age, Miscarriage, Congenital Abnormalities, Central Nervous System Neoplasms, Interviews as Topic, 03 medical and health sciences, 0302 clinical medicine, Epidemiology, medicine, risk factors, Birth Weight, Humans, 030212 general & internal medicine, education, Child, Reproductive History, education.field_of_study, business.industry, Gestational age, Infant, medicine.disease, 3. Good health, Birth order, Breast Feeding, Oncology, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, 030220 oncology & carcinogenesis, Case-Control Studies, Child, Preschool, Etiology, epidemiology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Female, France, business, Maternal Age
Abstract: International audience; BACKGROUND: Determining the role of pre- and perinatal factors in the aetiology of childhood malignant central nervous (CNS) tumors, using data from the French national case-control study, ESCALE. METHODS: ESCALE included all children in France less than 15 years old with a diagnosis of acute leukaemia, lymphoma, malignant CNS tumor, or neuroblastoma (2003-2004). In all, 209 malignant CNS tumor cases (80% of the eligible cases) and 1681 population-based controls (71%) were included using quotas ensuring frequency matching with the cases by age and gender. Case and control mothers were interviewed using a standardised telephone interview, which elicited birth characteristics, congenital malformation, maternal reproductive history, and use of assisted reproductive technologies for the index child. RESULTS: The cases and controls did not differ in terms of gestational age at birth, birth weight, birth order, breastfeeding, or parental age at birth. There was no association between assisted reproduction for the index child and malignant CNS tumor (OR=1.1 [0.6-2.2]). A positive association between a maternal history of one miscarriage and malignant CNS tumor was observed (OR=1.4 [1.0-2.0], p
Published: 2008
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18. Parental smoking, maternal alcohol, coffee and tea consumption during pregnancy and childhood malignant central nervous system tumours: the ESCALE study (SFCE)

Author: Dominique Plantaz, Didier Frappaz, Denis Hémon, Jacqueline Clavel, Brigitte Lacour, Xavier Rialland, Celine Icher, François Doz, Olivier Hartmann, Anne-Isabelle Bertozzi, Pascal Chastagner, Anne-Sophie Defaschelles, Matthieu Plichart, Alain Pierre-Kahn, Florence Menegaux, Secretariat, U754, Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Registre National des Tumeurs Solides de l'Enfant (RNTSE), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Cancéropôle du Grand Est, Département de Pédiatrie, Institut Gustave Roussy (IGR), Centre Léon Bérard [Lyon], Institut Curie [Paris], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Institut de médecine predictive et de recherche thérapeutique (IMPRT), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] (UNICANCER/Lille), Université de Lille-UNICANCER-Université de Lille-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Pellegrin, CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Département de pédiatrie, CHU Grenoble-Hôpital Michallon, Centre Robert Debré, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Registre National des Hémopathies malignes de l'Enfant (RNHE), Institut de Veille Sanitaire (INVS)-Institut National de la Santé et de la Recherche Médicale (INSERM), This work was supported by grants from INSERM, the Fondation de France, the Association pour la Recherche contre le Cancer (ARC), the Agence Française de Sécurité Sanitaire des Produits de Santé (AFSSAPS), the Agence Française de Sécurité Sanitaire de l'Environnement et du Travail (AFSSET) and the association 'Cent pour sang la vie'., Hôpital des Enfants, CHU Toulouse [Toulouse], Université Lille Nord de France (COMUE)-UNICANCER-Université Lille Nord de France (COMUE)-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Registre National des Tumeurs Solides de l'Enfant ( RNTSE ), Centre Hospitalier Régional Universitaire de Nancy ( CHRU Nancy ) -Cancéropôle du Grand Est, Institut Gustave Roussy ( IGR ), Institut Curie, Hôpital des enfants, Institut de médecine predictive et de recherche thérapeutique ( IMPRT ), Réseau International des Instituts Pasteur ( RIIP ) -Réseau International des Instituts Pasteur ( RIIP ) -CRLCC Oscar Lambret-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] ( CHRU Lille ), Centre Hospitalier Régional Universitaire de Nancy ( CHRU Nancy ), CHU Angers, Registre National des Hémopathies malignes de l'Enfant ( RNHE ), and Institut de Veille Sanitaire (INVS)-Institut National de la Santé et de la Recherche Médicale ( INSERM )
Subjects: Male, Pathology, MESH : Tea, MESH: Chi-Square Distribution, Physiology, MESH: Logistic Models, MESH : Central Nervous System Neoplasms, MESH: Risk Assessment, alcohols, MESH: Central Nervous System Neoplasms, Central Nervous System Neoplasms, 0302 clinical medicine, MESH: Pregnancy, MESH : Child, Pregnancy, Reference Values, MESH: Child, MESH: Incidence, Child, education.field_of_study, Incidence, MESH: Sex Distribution, MESH: Reference Values, MESH : Infant, MESH : Maternal Exposure, [ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Follow-Up Studies, MESH: Infant, MESH: Case-Control Studies, MESH : Incidence, MESH : Paternal Exposure, 3. Good health, Oncology, risk factor, Maternal Exposure, Child, Preschool, 030220 oncology & carcinogenesis, Paternal Exposure, MESH : Case-Control Studies, medicine.medical_specialty, Alcohol Drinking, MESH: Probability, Risk Assessment, Article, MESH : Tobacco Smoke Pollution, 03 medical and health sciences, MESH : Adolescent, Humans, Risk factor, education, MESH: Age Distribution, Survival analysis, MESH: Adolescent, Chi-Square Distribution, MESH: Humans, MESH : Chi-Square Distribution, MESH : Humans, MESH: Child, Preschool, Public Health, Environmental and Occupational Health, Case-control study, Infant, MESH: Coffee, MESH : Follow-Up Studies, MESH: Adult, Odds ratio, medicine.disease, MESH : Coffee, Survival Analysis, MESH : Pregnancy, MESH : Alcohol Drinking, Logistic Models, Brain neoplasms, Case-Control Studies, Tobacco Smoke Pollution, MESH: Female, MESH: Alcohol Drinking, MESH : Logistic Models, Cancer Research, tea, MESH : Age Distribution, MESH : Child, Preschool, Epidemiology, MESH : Female, 030212 general & internal medicine, MESH : Risk Assessment, MESH: Maternal Exposure, MESH : Sex Distribution, Incidence (epidemiology), MESH: Tea, MESH : Adult, MESH: Survival Analysis, MESH: Tobacco Smoke Pollution, Female, epidemiology, France, Adult, Adolescent, MESH : Male, MESH : Probability, Population, coffee, MESH : Reference Values, smoking, Age Distribution, medicine, Sex Distribution, MESH : France, Probability, MESH: Paternal Exposure, business.industry, MESH: Male, MESH: France, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH : Survival Analysis, business, Follow-Up Studies
Abstract: International audience; Parental smoking and maternal alcohol and caffeinated beverage consumption are prevalent exposures which may play a role, either directly or through their influence on metabolism, in the aetiology of childhood malignant central nervous system (CNS) tumours. The hypothesis was investigated in the Epidemiological Study on childhood Cancer and Leukemia ESCALE study, a national population-based case-control study carried out in France in 2003-2004. The study included 209 incident cases of CNS tumours and 1681 population-based controls, frequency matched with the cases by age and sex. The data were collected through a standardized telephone interview of the biological mothers. No association between maternal smoking during pregnancy and CNS tumours [odds ratio (OR): 1.1 (0.8-1.6)] was observed. Paternal smoking during the year before birth was associated with CNS tumours (P for trend=0.04), particularly astrocytomas [OR: 3.1 (1.3-7.6)]. Maternal alcohol consumption during pregnancy was not associated with CNS tumours. Associations between ependymomas and the highest consumption of coffee [OR: 2.7 (0.9-8.1)] and tea [OR: 2.5 (1.1-5.9)] were observed. A strong association between CNS tumours and the highest maternal consumption of both coffee and tea during pregnancy was observed [OR: 4.4 (1.5-13)]. The results constitute additional evidence for a role of paternal smoking and suggest that maternal coffee and tea consumption during pregnancy may also increase the risk of CNS tumours. The study does not suggest an increased risk of CNS tumours related to alcohol consumption during pregnancy.
Published: 2008
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19. Childhood leukaemia and population movements in France, 1990-2003

Author: Jérémie Rudant, Brigitte Baccaïni, Denis Hémon, A. Goubin, Jacqueline Clavel, M. Ripert, Stéphanie Bellec, Secretariat, U754, Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Registre National des Hémopathies malignes de l'Enfant (RNHE), Institut de Veille Sanitaire (INVS)-Institut National de la Santé et de la Recherche Médicale (INSERM), INSEE Provence-Alpes-Côte d'Azur, and INSEE
Subjects: Cancer Research, Pediatrics, medicine.medical_specialty, Epidemiology, Population, population movements, Population density, 03 medical and health sciences, 0302 clinical medicine, medicine, 030212 general & internal medicine, education, population density, education.field_of_study, business.industry, Incidence (epidemiology), Childhood leukaemia, infectious aetiology hypothesis, 3. Good health, Oncology, El Niño, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, 030220 oncology & carcinogenesis, National study, Etiology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Demography, Cohort study
Abstract: International audience; In a national study, we investigated the incidence of childhood leukaemia (CL) over a 14-year period in France in relation to several measures based on the proportion of individuals who changed address between the last two national censuses. A positive association was found with the proportion of migrants who came from a distant place. The further the migrants came, the higher was the incidence of leukaemia, particularly among children aged 0-4 years in 'isolated' communes at the time of diagnosis (RR=1.4, 95% CI: 1.1,1.8 in the highest category of migration distance). Although the role of the population density was less obvious, a more marked association was found above a certain threshold. No association with the proportion of commuters was observed.British Journal of Cancer (2008) 98, 225-231. doi:10.1038/sj.bjc.6604141 www.bjcancer.com Published online 18 December 2007.
Published: 2008
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20. Childhood hematopoietic malignancies and parental use of tobacco and alcohol: the ESCALE study (SFCE)

Author: Yves Bertrand, Alain Robert, Guy Leverger, Jacqueline Clavel, Jérémie Rudant, Gérard Michel, Denis Hémon, André Baruchel, Florence Menegaux, Catherine Patte, Hélène Pacquement, Cécile Vérité, Anne Lambilliotte, Geneviève Margueritte, Virginie Gandemer, Secretariat, U754, Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'hématologie-immunologie-oncologie pédiatrique [CHU Trousseau], Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Service d'hématologie et immunologie pédiatrique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 (UPD7), Service d'hématologie pédiatrique-oncologie, Hôpital Jeanne de Flandre [Lille], Hôpital Debrousse, Hospices Civils de Lyon (HCL), LMB, Institut Gustave Roussy (IGR), Neuroendocrinologie cellulaire et moléculaire, Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Curie [Paris], Hôpital Pellegrin Tripode, Pôle Enfants [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Hôpital de la Timone [CHU - APHM] (TIMONE), Hôpital Arnaud de Villeneuve [CHRU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Hôpital Sud, Registre National des Hémopathies malignes de l'Enfant (RNHE), Institut de Veille Sanitaire (INVS)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Hôpital d'enfants
Subjects: Male, Cancer Research, Pediatrics, Alcohol, chemistry.chemical_compound, 0302 clinical medicine, Pregnancy, Surveys and Questionnaires, hemic and lymphatic diseases, Epidemiology, Odds Ratio, Alcohol consumption, Registries, 030212 general & internal medicine, Child, Children, Hodgkin's lymphoma, Incidence, Lymphoma, Non-Hodgkin, Smoking, Non-Hodgkin's lymphoma, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Burkitt Lymphoma, Hodgkin Disease, 3. Good health, Maternal alcohol, Leukemia, Myeloid, Acute, Oncology, Maternal Exposure, Child, Preschool, Hematologic Neoplasms, Prenatal Exposure Delayed Effects, 030220 oncology & carcinogenesis, Paternal Exposure, Female, France, medicine.medical_specialty, Alcohol Drinking, Parental smoking, 03 medical and health sciences, medicine, Humans, Acute leukemia, business.industry, Public health, medicine.disease, Logistic Models, chemistry, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Case-Control Studies, Etiology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business
Abstract: International audience; OBJECTIVES: Investigating the role of parental smoking and maternal alcohol consumption in the etiology of childhood hematopoietic malignancies. METHODS: The national registry-based case-control study ESCALE was carried out in France over the period 2003-2004. Population controls were frequency matched with the cases on age and gender. Maternal smoking and alcohol consumption during pregnancy and paternal smoking since before conception were reported by the mothers in a structured telephone questionnaire. Odds ratios (OR) were estimated using unconditional regression models closely adjusted for potential confounders. RESULTS: A total of 765 cases of acute leukemia (AL), 130 of Hodgkin's lymphoma (HL), 165 of non-Hodgkin's lymphoma (NHL) and 1681 controls were included. Paternal smoking was significantly associated with childhood ALL (OR = 1.4 [1.1-1.7]), AML (OR = 1.5 [1.0-2.3]), Burkitt (OR = 2.0 [1.2-3.2]), and anaplastic large cell (OR = 3.2 [1.2-9.1]) NHL. For the four diseases, the ORs significantly increased with the number of cigarettes smoked. No association with HL or with other types of NHL was observed. The associations with maternal alcohol consumption and cigarette smoking during pregnancy were less consistent. CONCLUSION: The results support the hypothesis that only paternal smoking, and not maternal alcohol consumption or cigarette smoking, plays a role in childhood hematopoietic malignancies.
Published: 2008
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21. Childhood cancer survival in France, 1990-1999

Author: Brigitte Lacour, Danièle Sommelet, Lionel de Lumley, Claire Berger, Edouard Le Gall, A. Goubin, Stéphanie Bellec, Jacqueline Clavel, Emmanuel Desandes, Léonie Casagranda, Fernand Freycon, François Demeocq, Isabelle Tron, P. Blouin, Registre National des Tumeurs Solides de l'Enfant (RNTSE), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Cancéropôle du Grand Est, Registre des Cancers de l'Enfant de Lorraine, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Registre des Cancers de l'Enfant de Rhônes-Alpes, CHU Saint Etienne, Registre des Cancers de l'Enfant de Bretagne, Registre des Cancers de l'Enfant d'Auvergne-Limousin, CHU Clermont-Ferrand, Registre National des Hémopathies malignes de l'Enfant (RNHE), Institut de Veille Sanitaire (INVS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Registre des Cancers du Val-de-Marne, Institut de Veille Sanitaire (INVS), Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Secretariat, U754
Subjects: Male, Cancer Research, Pediatrics, medicine.medical_specialty, MESH: Children, Adolescent, Population level, Childhood cancer, Population, MESH: Prognosis, 03 medical and health sciences, Age Distribution, 0302 clinical medicine, MESH: Survival, MESH: Registry, Neoplasms, Humans, Medicine, Area of residence, Mortality, Stage (cooking), Child, education, MESH: Population-based study, 030304 developmental biology, 0303 health sciences, education.field_of_study, MESH: Cancer, business.industry, Infant, Second cancer, Cancer, medicine.disease, 3. Good health, Oncology, El Niño, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Child, Preschool, 030220 oncology & carcinogenesis, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, Epidemiologic Methods, business
Abstract: ERMA; International audience; The aim of this study was to describe the overall survival after childhood cancer in France using follow-up data from regional population-based registries. The survival of children (aged under 15 years) diagnosed with a cancer during 1990-1999 was analysed. For all cancers, the survivals were, respectively, 90.3% [89.4-91.3] at 1-year, 75.2% [73.8-76.6] at 5 years and 72.2% [70.7-73.7] at 10 years. During the 1990s, the average improvement in the 5-year survival was +1.2% per year. Adjusted for gender, age, area of residence and stage, children with cancer diagnosed between 1995 and 1999 had a 0.80 reduced risk of dying compared with those whose cancer had been diagnosed between 1990 and 1994. The increase of survival at the population level reflects a global improvement in childhood cancer care. The Paediatric Registries, in association with the French Society of Childhood Cancer, are now collecting data to quantify on a national basis the other events, at least relapse and second cancers.
Published: 2008
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22. Occupation and lymphoid malignancies: results from a French case-control study

Author: Michel Leporrier, Alain Monnereau, Pierre Soubeyran, Laurent Orsi, Xavier Troussard, Gerald Marit, Jacqueline Clavel, Denis Hémon, Noel Milpied, Christian Berthou, Françoise Huguet, Pierre Fenaux, Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire d'Hématologie Biologique [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Plateforme de génétique moléculaire des cancers d'Aquitaine, Institut Bergonié [Bordeaux], UNICANCER-UNICANCER, Hôpital Morvan, Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Service d'hématologie clinique [Avicenne], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris 13 (UP13)-Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service des maladies du sang, CHU Bordeaux [Bordeaux]-Hôpital Haut-Lévêque [CHU Bordeaux], CHU Bordeaux [Bordeaux]-Groupe Hospitalier Sud, Laboratoire d'Hématologie [Purpan], Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse], Service d'Hématologie Hôtel Dieu Nantes, Hôtel Dieu, CHU Bordeaux [Bordeaux]-Groupe Hospitalier Sud-Hôpital Haut-Lévêque [CHU Bordeaux], CHU Bordeaux [Bordeaux], Secretariat, U754, Université Paris 13 (UP13)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne [AP-HP], Service Hématologie - IUCT-Oncopole [CHU Toulouse], Pôle Biologie [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Pôle IUCT [CHU Toulouse], and Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)
Subjects: Adult, Employment, Male, Oncology, medicine.medical_specialty, Adolescent, case-control study, lymphoma, farming, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, immune system diseases, Internal medicine, Immunopathology, hemic and lymphatic diseases, Epidemiology, medicine, Humans, Occupations, Risk factor, Multiple myeloma, Aged, risk, business.industry, Incidence, Public Health, Environmental and Occupational Health, Case-control study, Cancer, Odds ratio, occupational exposure, Middle Aged, medicine.disease, 030210 environmental & occupational health, 3. Good health, Lymphoma, Surgery, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Case-Control Studies, 030220 oncology & carcinogenesis, Female, epidemiology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, Multiple Myeloma, business
Abstract: International audience; OBJECTIVES: Investigating relationships between potential occupational risk factors and lymphoid malignancy (LM). METHODS: We conducted a multicenter hospital-based case-control study in France between 2000 and 2004, including 824 incident cases of non-Hodgkin lymphoma (NHL), Hodgkin lymphoma (HL), multiple myeloma, and "lymphoproliferative syndrome" and 752 frequency-matched controls. Data were collected through face-to-face standardized and detailed interviews. RESULTS: Farming was significantly associated with NHL (odds ratio [OR] = 1.4 [1.0 to 2.0]) and, although not significantly, with lymphoproliferative syndrome and multiple myeloma. ORs were higher for longest durations of exposure. Self-declared exposure to pesticides was significantly associated with NHL (OR = 1.8 [1.2 to 2.7]) and HL (OR = 2.2 [1.0 to 4.7]). Neither solvent-related jobs nor self-reported exposure to solvents were related to LM. Systematic screening based on job titles did not evidence any other association. CONCLUSIONS: The results support the hypothesis that farming plays a role in most types of LM.
Published: 2007
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23. Household exposure to pesticides and risk of childhood hematopoietic malignancies: The ESCALE study (SFCE)

Author: Florence Menegaux, Guy Leverger, Jacqueline Clavel, Geneviève Margueritte, Denis Hémon, Jérémie Rudant, Virginie Gandemer, Gérard Michel, Hélène Pacquement, Brigitte Nelken, André Baruchel, Catherine Patte, Cécile Vérité, Yves Bertrand, Alain Robert, Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'hématologie-immunologie-oncologie pédiatrique [CHU Trousseau], Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Service d'hématologie pédiatrique, Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Service d'Hématologie-Oncologie Pédiatrique, Hôpital Jeanne de Flandre [Lille]-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Hôpital Debrousse, Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Neuroendocrinologie cellulaire et moléculaire, Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Curie [Paris], Hôpital Pellegrin Tripode, Hôpital des Enfants, CHU Toulouse [Toulouse], Hôpital de la Timone [CHU - APHM] (TIMONE), SFO Enseignement, SFO, Hôpital Sud, hôpital Sud, Registre National des Hémopathies malignes de l'Enfant (RNHE), Institut de Veille Sanitaire (INVS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Secretariat, U754, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), and Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)
Subjects: Pediatrics, MESH: Registries, Health, Toxicology and Mutagenesis, 010501 environmental sciences, 01 natural sciences, 0302 clinical medicine, Nodular sclerosis, Risk Factors, MESH: Risk Factors, MESH: Child, acute leukemia, Registries, Child, Family Characteristics, Sex Characteristics, education.field_of_study, Hodgkin's lymphoma, non-Hodgkin lymphoma, Environmental exposure, MESH: Case-Control Studies, 3. Good health, Hematologic Neoplasms, 030220 oncology & carcinogenesis, Children's Health, pregnancy, MESH: Sex Characteristics, acute leukaemia, non-Hodgkin's lymphoma, medicine.medical_specialty, MESH: Socioeconomic Factors, Population, MESH: Environmental Exposure, 03 medical and health sciences, children, medicine, MESH: Family Characteristics, Humans, MESH: Pesticides, Pesticides, education, pesticide, 0105 earth and related environmental sciences, Pregnancy, MESH: Humans, business.industry, Research, Public Health, Environmental and Occupational Health, Case-control study, Environmental Exposure, Odds ratio, medicine.disease, Non-Hodgkin's lymphoma, Socioeconomic Factors, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Case-Control Studies, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Hodgkin lymphoma, MESH: Hematologic Neoplasms
Abstract: International audience; OBJECTIVES: We investigated the role of household exposure to pesticides in the etiology of childhood hematopoietic malignancies. METHODS: The national registry-based case-control study ESCALE (Etude sur les cancers de l'enfant) was carried out in France over the period 2003-2004. Population controls were frequency matched with the cases on age and sex. Maternal household use of pesticides during pregnancy and paternal use during pregnancy or childhood were reported by the mothers in a structured telephone questionnaire. Insecticides (used at home, on pets, or for garden crops), herbicides, and fungicides were distinguished. We estimated odds ratios (ORs) using unconditional regression models closely adjusting for age, sex, degree of urbanization, and type of housing (flat or house). RESULTS: We included a total of 764 cases of acute leukemia (AL), 130 of Hodgkin lymphoma (HL), 166 of non-Hodgkin lymphoma (NHL), and 1,681 controls. Insecticide use during pregnancy was significantly associated with childhood AL [OR = 2.1; 95% confidence interval (CI), 1.7-2.5], both lymphoblastic and myeloblastic, NHL (OR = 1.8; 95% CI, 1.3-2.6), mainly for Burkitt lymphoma (OR = 2.7; 95% CI, 1.6-4.5), and mixed-cell HL (OR = 4.1; 95% CI, 1.4-11.8), but not nodular sclerosis HL (OR = 1.1; 95% CI, 0.6-1.9). Paternal household use of pesticides was also related to AL (OR = 1.5; 95% CI, 1.2-1.8) and NHL (OR = 1.7; 95% CI, 1.2-2.6); but for AL the relationships did not remain after adjustment for maternal pesticide use during pregnancy. CONCLUSION: The study findings strengthen the hypothesis that domestic use of pesticides may play a role in the etiology of childhood hematopoietic malignancies. The consistency of the findings with those of previous studies on AL raises the question of the advisability of preventing pesticide use by pregnant women.
Published: 2007
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24. Familial history of cancer and childhood acute leukemia: a French population-based case-control study

Author: Lionel de Lumley, Corinne Armari-Alla, Martine Munzer, Jacqueline Clavel, Alain Robert, Jean-Pierre Lamagnere, Christian Berthou, Patrick Boutard, Florence Menegaux, Virginie Gandemer, Patrick Lutz, Francoise Mechinaud, Emmanuel Plouvier, Brigitte Pautard, Frédéric Millot, Jean-Pierre Vannier, M. Ripert, Geneviève Margueritte, Xavier Rialland, Yves Perel, Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Pellegrin, CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, Hôpital mère et enfant, Hôpital Saint-Jacques, Hôpital Sud, hôpital Sud, Hôpital Civil, Hopital Civil, CHU Rouen, Normandie Université (NU), CHRU Clocheville, SFO Enseignement, SFO, Hôpital Côte de Nacre [CHU Caen], CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Hôpital d'enfants, Hôpital de la Tronche, American Memorial Hospital, American Memory Hospital, Hôpital Jean Bernard, CHU Limoges, Hôpital Morvan, Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Centre Robert Debré, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), CHU Amiens-Picardie, Pôle Enfants [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), and Secretariat, U754
Subjects: Male, Oncology, Cancer Research, Pediatrics, Epidemiology, 0302 clinical medicine, Neoplasms, MESH: Child, Medicine, MESH: Neoplasms, 030212 general & internal medicine, Child, Acute leukemia, education.field_of_study, MESH: Infant, Newborn, leukemia, familial history, Myeloid leukemia, MESH: Case-Control Studies, MESH: Infant, 3. Good health, Leukemia, Child, Preschool, 030220 oncology & carcinogenesis, Acute Disease, MESH: Acute Disease, Female, medicine.medical_specialty, Adolescent, case-control study, Population, Article, 03 medical and health sciences, Internal medicine, MESH: Leukemia, Humans, Family, education, MESH: Family, childhood, MESH: Adolescent, MESH: Humans, business.industry, MESH: Child, Preschool, Infant, Newborn, Public Health, Environmental and Occupational Health, Case-control study, Infant, Cancer, Odds ratio, medicine.disease, MESH: Male, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Case-Control Studies, Etiology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Female
Abstract: International audience; A case-control study was conducted to investigate the role of a familial history of cancer in the etiology of childhood acute leukemia. The history of cancer in the relatives of 472 cases was compared with that of 567 population-based controls. Recruitment was frequency matched on age, sex and region. The familial history of cancer in each child's relatives was reported by the mother in response to a standardized self-administered questionnaire. A familial history of solid tumor in first or second-degree relatives was associated with an increased risk of acute lymphoblastic leukemia (odds ratio (OR)=1.6 [95% confidence interval, 1.2-2.1]), while a familial history of hematopoietic malignancies in first or second-degree relatives was associated with an increased risk of acute myeloid leukemia (OR=4.3 [1.4-13]). The ORs for the histories of cancer increased with the number of relatives with cancer (OR=1.5 [1.1-2.0] for one relative and OR=2.3 [1.3-3.8] for two relatives or more; Ptrend
Published: 2007
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25. Alcohol Drinking, Tobacco Smoking, and Anthropometric Characteristics as Risk Factors for Thyroid Cancer: A Countrywide Case-Control Study in New Caledonia

Author: Guignard, Romain, Truong, Thérèse, Rougier, Yannick, Baron-Dubourdieu, Dominique, Guénel, Pascal, Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pasteur de Nouvelle-Calédonie, Réseau International des Instituts Pasteur (RIIP), Laboratory of Anatomy and Cytopathology, This study was supported by grants from the 'Fondation de France', the 'Association pour la Recherche contre le Cancer', and the 'Agence Française de Sécurité Sanitaire de l'Environnement et du Travail (AFSSET)', and Secretariat, U754
Subjects: MESH: Smoking, MESH: adverse effects, body mass index, smoking, MESH: Adenocarcinoma Follicular, New Caledonia, MESH: Anthropometry, MESH: Risk Factors, MESH: Carcinoma Papillary, MESH: Aged, MESH: Humans, MESH: Body Size, thyroid neoplasms, MESH: etiology Case-Control Studies, MESH: Adult, case control study, alcohol drinking, MESH: Male, MESH: Middle Aged New Caledonia, MESH: Odds Ratio, MESH: Thyroid Neoplasms, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, body height, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: epidemiology, MESH: etiology, MESH: Female, MESH: Alcohol Drinking
Abstract: International audience; Exceptionally high incidence rates of thyroid cancer are observed in New Caledonia, particularly in Melanesian women. To investigate further the etiology of thyroid cancer and to clarify the reasons of this elevated incidence, the authors conducted a countrywide population-based case-control study in this multiethnic population. The study included 332 cases with histologically verified papillary or follicular carcinoma (293 women and 39 men) diagnosed in 1993-1999 and 412 population controls (354 women and 58 men) frequency matched by gender and 5-year age group. Thyroid cancer was negatively associated with tobacco smoking and alcohol drinking, but no inverse dose-response relation was observed. Height was positively associated with thyroid cancer, particularly in men. Strong positive associations with weight and body mass index were observed in Melanesian women aged 50 years or more, with an odds ratio of 5.5 (95% confidence interval: 1.5, 20.3) for a body mass index of 35 kg/m(2) or greater compared with normal-weight women, and there was a clear dose-response trend. This study clarifies the role of overweight for thyroid cancer in postmenopausal women. Because of the high prevalence of obesity among Melanesian women of New Caledonia, this finding may explain in part the exceptionally elevated incidence of thyroid cancer in this group.
Published: 2007
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26. Up-to-date monitoring of childhood cancer long-term survival in Europe: leukaemias and lymphomas

Author: I. Izarzugaza, Donald Maxwell Parkin, Eva Steliarova-Foucher, Jan Willem Coebergh, Volker Arndt, Hermann Brenner, Jacqueline Clavel, Division of Clinical Epidemiology and Aging Research, German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Department of Public Health, Erasmus University Medical Centre, Rotterdam, Erasmus University Medical Centre, Rotterdam, Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, University of Oxford [Oxford], Basque Country Cancer Registry, Vitoria-Gasteiz, Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Groupe Epidémiologie Descriptive, IARC, Secretariat, U754, University of Oxford, and Public Health
Subjects: Male, Oncology, medicine.medical_specialty, Adolescent, Databases, Factual, Lymphoma, medicine.medical_treatment, Childhood cancer, 03 medical and health sciences, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Internal medicine, hemic and lymphatic diseases, medicine, Humans, Registries, 030212 general & internal medicine, Child, Survival rate, Survival analysis, Chemotherapy, Leukemia, business.industry, Infant, Cancer, Hematology, medicine.disease, Survival Analysis, 3. Good health, Europe, El Niño, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Child, Preschool, 030220 oncology & carcinogenesis, Immunology, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business
Abstract: BACKGROUND: In recent decades, following the introduction of effective chemotherapy, the prognosis of children with leukaemia and lymphoma has dramatically improved, but data reflecting further possible improvement achieved in the 1990s are scarce. METHODS: Using the Automated Childhood Cancer Information (ACCIS) database, we carried out a period analysis of 10-year survival for the 1995-99 period. Analyses were carried out by diagnostic groups, age-group at diagnosis, sex and four European regions. RESULTS: Ten-year survival estimates for the 1995-99 period were 73% for any type of leukaemia, 78% for acute lymphoid leukaemia and 52% for acute non-lymphocytic leukaemia. The corresponding 10-year survival rates for all types of lymphomas, Hodgkin lymphoma, and non-Hodgkin lymphoma were 84, 91 and 79%, respectively. These figures are much higher than those obtained by traditional (cohort-based) methods of survival analysis. A large difference in prognosis is still observed between the East and other parts of Europe. CONCLUSION: Major improvement in prognosis for children with leukaemia or lymphoma has been ongoing in Europe during the 1990s, but further monitoring and investments are required to remove the large regional differences between European regions.
Published: 2007
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27. The impact of major heat waves on all-cause and cause-specific mortality in France from 1971 to 2003

Author: Pierre Bessemoulin, Eric Jougla, Grégoire Rey, Philippe Frayssinet, Jacqueline Clavel, Anne Fouillet, Gérard Pavillon, Denis Hémon, Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d'épidémiologie sur les causes médicales de décès (CépiDc), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Météo-France [Paris], Météo France, Registre National des Hémopathies malignes de l'Enfant (RNHE), Institut de Veille Sanitaire (INVS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Météo-France, and Secretariat, U754
Subjects: Male, Hot Temperature, Poison control, 010501 environmental sciences, 01 natural sciences, MESH: Cause of Death, 0302 clinical medicine, Cause of Death, Epidemiology, 030212 general & internal medicine, Cause of death, 2. Zero hunger, MESH: Aged, education.field_of_study, MESH: Middle Aged, Mortality rate, Age Factors, Heatstroke, Middle Aged, 3. Good health, Female, France, Hyperthermia, Adult, medicine.medical_specialty, Population, MESH: Heat, Article, 03 medical and health sciences, Sex Factors, MESH: Sex Factors, Injury prevention, medicine, Humans, Mortality, education, 0105 earth and related environmental sciences, Aged, MESH: Age Factors, MESH: Humans, MESH: Mortality, business.industry, Public Health, Environmental and Occupational Health, MESH: Adult, medicine.disease, MESH: Male, MESH: France, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Female, Demography
Abstract: International audience; OBJECTIVES: The aim of the study was to identify the major heat waves (HW) that occurred in France from 1971 to 2003 and describe their impact on all-cause and cause-specific mortality. METHODS: Heat waves were defined as periods of at least three consecutive days when the maximum and the minimum temperature, averaged over the whole France, were simultaneously greater than their respective 95th percentile. The underlying causes of death were regrouped into 18 categories. Heatstroke, hyperthermia and dehydration were assigned to the "heat-related causes" (HRC) category. The numbers of deaths observed (O) during the identified HW were compared to those expected (E) on the basis of the mortality rates reported for the three preceding years. RESULTS: Six HW were identified from the period 1971 to 2003. They were associated with great excess mortality (from 1,300 to 13,700 deaths). The observations are compatible with a moderate harvesting effect for four of the six HW. The mortality ratios increased with age for subjects aged over 55 years and were higher for women than for men over 75 years. For the six HW, the excess mortality was significant for almost all the causes of death: (1) the greatest excess mortality (O-E) were observed for cardiovascular diseases, neoplasms, respiratory system diseases, HRC, ill-defined conditions and injury and poisoning, and (2) the mortality ratios (O/E) were highest for HRC, respiratory diseases, nervous system diseases, mental disorders, infectious diseases, and endocrine and nutritional diseases. CONCLUSIONS: Heat waves associated with excess mortality are not rare events in this temperate-climate country. The excess mortality is much greater than HRC mortality. Some populations are particularly vulnerable to HW: the elderly, women and people with some specific diseases. However, no segment of the population may be considered protected from the risks associated with HW.
Published: 2007
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28. Family history of cancer in children with acute leukemia, Hodgkin's lymphoma or non-Hodgkin's lymphoma: the ESCALE study (SFCE)

Author: André Baruchel, Olivier Hartmann, Jacqueline Clavel, Cécile Vérité, Denis Hémon, Guy Leverger, Brigitte Nelken, Jérémie Rudant, Hélène Pacquement, Florence Menegaux, Gérard Michel, Geneviève Margueritte, Yves Bertrand, Alain Robert, Virginie Gandemer, Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'hématologie-immunologie-oncologie pédiatrique [CHU Trousseau], Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Service d'hématologie et immunologie pédiatrique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 (UPD7), Service hématologie-oncologie pédiatrique, Hôpital Jeanne de Flandre [Lille], Hôpital Debrousse, Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Département de Pédiatrie, Institut Gustave Roussy (IGR), Institut Curie [Paris], Hôpital Pellegrin Tripode, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Hôpital de la Timone [CHU - APHM] (TIMONE), SFO Enseignement, SFO, Hôpital Sud, Registre National des Hémopathies malignes de l'Enfant (RNHE), Institut de Veille Sanitaire (INVS)-Institut National de la Santé et de la Recherche Médicale (INSERM), This work was supported by grants from INSERM, the Fondation de France, the Association pour la Recherche contre le Cancer (ARC), the Agence Française de Sécurité Sanitaire des Produits de Santé (AFSSAPS), the Agence Française de Sécurité Sanitaire de l'Environnement et du Travail (AFSSET) and the association Cent pour sang la vie., Secretariat, U754, Hôpital des Enfants, and CHU Toulouse [Toulouse]
Subjects: Male, Oncology, Cancer Research, 0302 clinical medicine, MESH: Lymphoma, Non-Hodgkin, MESH: Child, Odds Ratio, Medicine, 030212 general & internal medicine, acute leukemia, Family history, Child, MESH: Aged, education.field_of_study, Acute leukemia, family history, MESH: Middle Aged, Hodgkin's lymphoma, Childhood Lymphoma, Lymphoma, Non-Hodgkin, MESH: Infant, Newborn, Middle Aged, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Hodgkin Disease, MESH: Infant, MESH: Case-Control Studies, MESH: Hodgkin Disease, 3. Good health, Leukemia, Myeloid, Acute, Child, Preschool, 030220 oncology & carcinogenesis, Female, Disease Susceptibility, MESH: Leukemia, Myeloid, Acute, Adult, non-Hodgkin's lymphoma, medicine.medical_specialty, Adolescent, Population, MESH: Disease Susceptibility, 03 medical and health sciences, children, Internal medicine, Humans, cancer, education, Aged, MESH: Adolescent, MESH: Precursor Cell Lymphoblastic Leukemia-Lymphoma, MESH: Humans, business.industry, MESH: Child, Preschool, Infant, Newborn, Infant, Cancer, MESH: Adult, Odds ratio, medicine.disease, MESH: Male, MESH: Odds Ratio, Non-Hodgkin's lymphoma, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Case-Control Studies, Immunology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Female
Abstract: International audience; The role of a family history of cancer in the etiology of childhood hematopoietic malignancies was investigated using the data from the ESCALE study. ESCALE, a population-based case-control study, was carried out in France over the period, 2003-2004. A total of 773 cases of acute leukemia (AL), 130 of Hodgkin's lymphoma (HL), 163 of non-Hodgkin's lymphoma (NHL) and 1,681 population-based controls were included. The controls were randomly selected from the French population and were frequency matched with the cases on age and gender. Cancer history in first- and second-degree relatives was reported by the mothers in a structured telephone questionnaire that was the same for the cases and controls. Odds ratios (ORs) were estimated using an unconditional regression model taking into account the stratification variables and potential confounders. A family history of cancer was associated with an increased risk of HL (OR = 1.5 [1.0-2.2]) and NHL (OR = 1.8 [1.3-2.5]), but not AL (OR = 1.0 [0.9-1.2]). The ORs were higher when at least 2 relatives had a history of cancer or when 1 case occurred before age 46 years. Only HL was significantly associated with a family history of hematopoietic malignancies (OR = 2.0 [1.0-3.8]), mainly because of a significant association with a history of HL (OR = 5.4 [1.3-22]). In conclusion, the study findings support the hypothesis of familial susceptibility to childhood lymphoma, but do not suggest familial susceptibility to childhood AL.
Published: 2007
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29. [Epidemiology of childhood cancers]

Author: Clavel, Jacqueline, Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Secretariat, U754
Subjects: Epstein-Barr Virus Infections, Leukemia, Neoplasms, Radiation-Induced, Adolescent, Incidence, Burkitt Lymphoma, Hodgkin Disease, Risk Factors, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Child, Preschool, Neoplasms, hemic and lymphatic diseases, Humans, Genetic Predisposition to Disease, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, Child, Environmental Pollution, Immunosuppressive Agents
Abstract: National audience; In industrial countries, 1 child out of 500 develops a cancer before the age of 15 years, and before the age of 6 years for almost half of them. In France, incidence rates were stable over the 15 last years with around 1500 cases each year. A very small fraction of cases is attributable to known risk factors, including heritable cancers or cancers in children with heritable predisposing diseases, cancers induced by high doses of ionizing radiation of medical or accidental origin, by chemotherapeutic or immunosuppressive drugs. Responsibility of Epstein Barr virus in a fraction of Hodgkin's and Burkitt's lymphomas is also established, even though little is still known on the cofactors involved in industrial countries. Other virus could cause leukaemia, as suggested by localized increases in incidence in various conditions of population mixing. Conversely, there is some evidence that early common infections could be protective toward leukaemia risk, probably through their contribution to the maturation of the immune system. Several agents are suspected to induce chemical cancers, particularly pesticides, which are consistently reported in childhood leukaemia and brain tumours. It is more and more likely that genetic factors may modulate risk induced of environmental factors.
Published: 2007

30. Authors' response

Author: Djamila Meguellati-Hakkas, Isabelle Stucker, Danièle Luce, Pascal Guenel, Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Santé publique et épidémiologie des déterminants professionnels et sociaux de la santé, Epidémiologie, sciences sociales, santé publique (IFR 69), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Secretariat, U754, and Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)
Subjects: 03 medical and health sciences, 0302 clinical medicine, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Public Health, Environmental and Occupational Health, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, 030212 general & internal medicine, 030210 environmental & occupational health, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2007
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31. Vaccination and the risk of childhood acute leukaemia: the ESCALE study (SFCE)

Author: Francoise Mechinaud, Anne Auvrignon, André Baruchel, Brigitte Nelken, Yves Bertrand, Alain Robert, Marie-Françoise Auclerc, Denis Hémon, Geneviève Margueritte, Jacqueline Clavel, Yves Perel, Nathalie Mallol-Mesnard, Pierre Bordigoni, Florence Menegaux, Gérard Michel, Guy Leverger, Secretariat, U754, Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'hématologie-immunologie-oncologie pédiatrique [CHU Trousseau], Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Service d'hématologie pédiatrique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Debrousse, Hospices Civils de Lyon (HCL), Service d'Hématologie-Oncologie Pédiatrique, Hôpital Jeanne de Flandre [Lille]-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Hôpital de la Timone [CHU - APHM] (TIMONE), Hôpital Arnaud de Villeneuve [CHRU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Hôpital Pellegrin, CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, Hôpital mère et enfant, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Hôpital des Enfants, and CHU Toulouse [Toulouse]
Subjects: Male, Pediatrics, MESH: Leukemia, Myelocytic, Acute, Epidemiology, MESH: Risk Assessment, 0302 clinical medicine, MESH: Leukemia, Lymphocytic, Acute, hemic and lymphatic diseases, MESH: Child, Medicine, Child, 0303 health sciences, education.field_of_study, Acute leukemia, Leukemia, Vaccination, MESH: Sex Distribution, General Medicine, Precursor Cell Lymphoblastic Leukemia-Lymphoma, MESH: Infant, MESH: Case-Control Studies, 3. Good health, Leukemia, Myeloid, Acute, Child, Preschool, 030220 oncology & carcinogenesis, Female, France, Risk assessment, medicine.medical_specialty, Hepatitis B vaccine, Adolescent, Childhood leukemia, Population, MESH: Drug Administration Schedule, Risk Assessment, Article, Drug Administration Schedule, 03 medical and health sciences, Age Distribution, MESH: Leukemia, Humans, Hepatitis B Vaccines, Sex Distribution, Risk factor, education, MESH: Age Distribution, 030304 developmental biology, MESH: Adolescent, MESH: Hepatitis B Vaccines, MESH: Humans, business.industry, MESH: Child, Preschool, Infant, MESH: Vaccination, medicine.disease, MESH: Male, MESH: France, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Case-Control Studies, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Female
Abstract: BACKGROUND: In 2002, a poster alerted the French health authorities to the possibility that the risk of childhood leukaemia might be increased by hepatitis B vaccination. Elucidating the role of vaccination in the aetiology of childhood acute leukaemia (AL) was therefore included in the objectives of an ongoing national study. METHODS: The ESCALE study was a French national population-based case-control study conducted in France in 2003 and 2004 in order to investigate the role of infectious, environmental and genetic factors in four childhood neoplastic diseases (leukaemia, lymphoma, neuroblastoma and brain tumour). The controls were randomly selected from the French population and age and gender frequency matched with the cases. A total of 776 cases of AL (91% of the eligible cases) and 1681 controls (71% of the eligible controls) were included. In a specific standardized telephone interview, which was the same for both the cases and controls, each mother was asked to read out her child's complete vaccination record. RESULTS: No association between vaccination and the risk of childhood AL: acute lymphoblastic leukaemia or acute myeloblastic leukaemia was observed. No relationship between the risk of leukaemia and the type of vaccine, number of doses of each vaccine, total number of injections, total number of vaccine doses or number of early vaccinations was evidenced. No confounding factor was observed. CONCLUSION: The study did not show any evidence of a role of vaccination in the aetiology of childhood leukaemia.
Published: 2007
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32. Risk factors for extrahepatic biliary tract carcinoma in men: medical conditions and lifestyle: results from a European multicentre case-control study

Author: Mogens Vyberg, Jorn Olsen, Pascal Guénel, Håkan Olsson, Antje Timmer, Linda Kaerlev, Wolfgang Ahrens, Nicole Raverdy, Lennart Hardell, Tony Fletcher, Maria Morales, Elsebeth Lynge, Franco Merletti, Enzo Merler, Secretariat, U754, Bremen Institute for Prevention Research and Social Medicine, Department of Medical Biometry and Statistics, University Hospital Freiburg, Institute of Pathology, Aarhus University Hospital, Public and Environmental Health Research Unit, London School of Hygiene and Tropical Medicine (LSHTM), Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Unit of Occupational and Environmental Epidemiology (CSPO), National Health Service, Unit of Cancer Epidemiology, Université de Turin-CERMS and Centre for Oncologic Prevention, Unit of Public Health and Environmental Care, Department of Preventive Medicine, Universitat de València (UV), Unit of Clinical Epidemiology, Dr Peset University Hospital, Department of Oncology, Lund University Hospital, Aarhus University [Aarhus], Örebro University Hospital [Örebro, Sweden], Center for National Clinical Databases South, Odense University Hospital, Registre général des cancers de la Somme, CHU Amiens-Picardie, Department of Public Health [Copenhagen], Faculty of Health and Medical Sciences, University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH), and University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU)
Subjects: Male, obesity, Etiology, Epidemiology, Medizin, Gastroenterology, Body Mass Index, 0302 clinical medicine, Bile Ducts, Extrahepatic, Cholelithiasis, Risk Factors, Medicine, Alcohol consumption, 2. Zero hunger, Biliary tract neoplasm, education.field_of_study, Smoking, Case-control study, Men, Gallstones, Middle Aged, medical history, 3. Good health, Biliary tract carcinoma, Biliary Tract Neoplasms, 030220 oncology & carcinogenesis, Medical history, 030211 gastroenterology & hepatology, Gallbladder Neoplasms, epidemiology, Gallbladder carcinoma, Adult, medicine.medical_specialty, Ampulla of Vater, alcohol consumption, case-control study, etiology, Population, Common Bile Duct Neoplasms, men, smoking, 03 medical and health sciences, Internal medicine, Humans, Obesity, Risk factor, education, Life Style, Aged, biliary tract carcinoma, Hepatology, business.industry, Odds ratio, medicine.disease, Confidence interval, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Case-Control Studies, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, gallbladder carcinoma, business, Body mass index
Abstract: OBJECTIVES: To identify risk factors of carcinoma of the extrahepatic biliary tract in men. METHODS: Newly diagnosed and histologically confirmed patients, 35-70 years old, were interviewed between 1995 and 1997 in Denmark, Sweden, France, Germany and Italy. Population controls were frequency-matched by age and region. Adjusted odds ratios and 95%-confidence intervals were estimated by logistic regression. RESULTS: The analysis included 153 patients and 1421 controls. The participation proportion was 71% for patients and 61% for controls. Gallstone disease was corroborated as a risk factor for extrahepatic biliary tract carcinoma in men (odds ratio 2.49; 95% confidence interval 1.32-4.70), particularly for gall bladder tumors (odds ratio 4.68; 95% confidence interval 1.85-11.84). For a body mass index [height (m) divided by squared weight (kg2)] >30 at age 35 years, an excess risk was observed (odds ratio 2.58; 95% confidence interval 1.07-6.23, reference: body mass index 18.5-25) that was even stronger if the body mass index was >30 for the lowest weight in adulthood (odds ratio 4.68; 95% confidence interval 1.13-19.40). Infection of the gall bladder, chronic inflammatory bowel disease, hepatitis or smoking showed no clear association, whereas some increase in risk was suggested for consumption of 40-80 g alcohol per day and more. CONCLUSIONS: Our study corroborates gallstones as a risk indicator in extrahepatic biliary tract carcinoma. Permanent overweight and obesity in adult life was identified as a strong risk factor for extrahepatic biliary tract carcinoma, whereas we did not find any strong lifestyle-associated risk factors. Inconsistent results across studies concerning the association of extrahepatic biliary tract carcinoma with overweight and obesity may be explained by the different approaches to assess this variable. Udgivelsesdato: 2007-Aug
Published: 2007
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33. Hodgkin's disease incidence and survival in European children and adolescents (1978-1997): report from the Automated Cancer Information System project

Author: Clavel, J, STELIAROVA FOUCHER, E, Berger, C, Danon, S, Valerianova, Z, Vercelli, Marina, Puppo, A., Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Registre National des Hémopathies malignes de l'Enfant (RNHE), Institut de Veille Sanitaire (INVS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Groupe Epidémiologie Descriptive, IARC, Registre des Cancers de l'Enfant de Rhônes-Alpes, CHU Saint Etienne, Bulgarian National Cancer Registry, National Oncological Hospital, and Secretariat, U754
Subjects: Male, Cancer Research, Pediatrics, Databases, Factual, MESH: Registries, 0302 clinical medicine, Nodular sclerosis, Residence Characteristics, MESH: Child, Epidemiology, Registries, MESH: Residence Characteristics, MESH: Incidence, Child, 0303 health sciences, Incidence, Incidence (epidemiology), MESH: Infant, Newborn, Hodgkin Disease, MESH: Infant, MESH: Hodgkin Disease, 3. Good health, Europe, Oncology, Child, Preschool, 030220 oncology & carcinogenesis, MESH: Survival Analysis, Female, Adult, medicine.medical_specialty, Adolescent, 03 medical and health sciences, medicine, Humans, Survival rate, Survival analysis, 030304 developmental biology, MESH: Adolescent, MESH: Humans, business.industry, MESH: Child, Preschool, Infant, Newborn, Infant, Cancer, MESH: Adult, medicine.disease, Survival Analysis, MESH: Databases, Factual, Confidence interval, MESH: Male, El Niño, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Hodgkin's disease - incidence and survival -children and adolescents, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Europe, business, MESH: Female
Abstract: This paper reports the geographical patterns and time trends of incidence and survival of Hodgkin's disease (HD) in children and adolescents in Europe over the period 1978-1997. Data on 4230 HD cases were gathered from 62 paediatric or general cancer registries in 19 European countries by the Automated Cancer Information System (ACCIS). European annual incidence rates in 1988-1997 were estimated at 5.8 per million in children (world age-standardised) and at 29.7 per million in adolescents, with higher rates in the East and South. Incidence rates increased steeply with age, while the male predominance, marked for the youngest children, vanished in the highest age groups. Over the period 1978-1997 incidence rates increased in age groups 10-14 years (+1% per year) and 15-19 years (+3.5% per year), mainly due to the nodular sclerosis subtype. Age and sex distribution of cases remained unchanged with time. The overall 5-year survival rate was higher in children (93%, 95% confidence interval (CI) 92-94) than in adolescents (89% (95% CI 87-91)) for the period 1988-1997. Five-year survival increased significantly in all regions from 87% to 93% in children and from 80% to 88% in adolescents between 1978-1982 and 1993-1997. In future, detailed documentation of cases in the cancer registries with respect to standardised diagnostic subtypes, stage of extension, and treatments, will help to refine interpretation of international and temporal variations in incidence and survival.
Published: 2006
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34. Childhood leukaemia incidence around French nuclear installations using geographic zoning based on gaseous discharge dose estimates

Author: Dominique Laurier, Jacqueline Clavel, Denis Hémon, Michel Chartier, Margot Tirmarche, Anne-Sophie Evrard, A. Morin, J. C. Backe, Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'études et d'expertise en radioprotection (DRPH/SER), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Radiobiologie et épidémiologie (DRPH/SRBE), Secretariat, U754, Service d'études et d'expertise en radioprotection (IRSN/DRPH/SER), and Service de RadioBiologie et d'Epidémiologie (IRSN/DRPH/SRBE)
Subjects: Male, Cancer Research, Pediatrics, MESH: Geography, Epidemiology, MESH: Leukemia, Myeloid, 01 natural sciences, 030218 nuclear medicine & medical imaging, 010104 statistics & probability, 0302 clinical medicine, MESH: Leukemia, Lymphocytic, Acute, MESH: Child, Medicine, MESH: Incidence, 030212 general & internal medicine, Child, MESH: Epidemiologic Studies, Geography, Incidence (epidemiology), Incidence, MESH: Infant, Newborn, Precursor Cell Lymphoblastic Leukemia-Lymphoma, MESH: Infant, 3. Good health, Childhood leukaemia, Oncology, Leukemia, Myeloid, 030220 oncology & carcinogenesis, Child, Preschool, Acute Disease, MESH: Acute Disease, MESH: Power Plants, Female, France, medicine.medical_specialty, Adolescent, nuclear sites, Red bone marrow, Precursor Cell Lymphoblastic Leukemia Lymphoma, 03 medical and health sciences, Age groups, childhood leukaemia, Humans, 0101 mathematics, MESH: Adolescent, MESH: Humans, business.industry, MESH: Child, Preschool, Infant, Newborn, Infant, estimated dose, Infant newborn, MESH: Male, Confidence interval, MESH: France, Epidemiologic Studies, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Zoning, business, MESH: Female, Demography, Power Plants
Abstract: International audience; The present study investigated for the first time the incidence of childhood leukaemia (1990-2001) around French nuclear installations using a geographic zoning based on estimated doses to the red bone marrow due to gaseous radioactive discharges. The observed number of cases of acute leukaemia (O=750) in 40 km2 centred on 23 French nuclear installations between 1990 and 2001 was lower than expected (E=795.01), although not significantly so (standardised incidence ratio SIR=0.94, 95% confidence interval=(0.88-1.01)). In none of the five zones defined on the basis of the estimated doses was the SIR significantly >1. There was no evidence of a trend in SIR with the estimated doses for all the children or for any of the three age groups studied. This study confirmed that there was no evidence of an increased incidence of childhood leukaemia around the 23 French nuclear sites.
Published: 2006
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35. Occupational sun exposure and mycosis fungoides: a European multicenter case-control study

Author: Preben Johansen, Franco Merletti, Patrick Arveux, Wolfgang Ahrens, Jørn Olsen, María Morales-Suárez-Varela, Gun Wingren, Lennart Hardell, Giovanna Masala, Francisco Guillén-Grima, Linda Kaerlev, Agustin Llopis, Pascal Guénel, Andreas Stang, Unit of Public Health and Environmental Care, University of Valencia, Unit of Clinical Epidemiology, Dr Peset University Hospital, The Danish Epidemiology Science Centre, Institute of Pathology, Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Registre des tumeurs du Doubs et du Territoire de Belfort [CHRU Besançon], Pôle cancérologie (CHRU Besançon), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Division of Occupational and Environmental Medicine, Linköping University (LIU), Department of Oncology, Örebro University Hospital [Örebro, Sweden], Bremen Institute for Prevention Research and Social Medicine, Unit of Cancer Epidemiology, Université de Turin-CERMS and Centre for Oncologic Prevention, Department of Health Science, Universidad de Navarra [Pamplona] (UNAV), Molecular and Nutritional Epidemiology Unit (CSPO), Scientific Institute of Tuscany, and Secretariat, U754
Subjects: Male, MESH: Occupational Exposure, 030207 dermatology & venereal diseases, 0302 clinical medicine, Risk Factors, MESH: Risk Factors, Epidemiology, Odds Ratio, MESH: Aged, education.field_of_study, MESH: Middle Aged, Pigmentation, Middle Aged, MESH: Case-Control Studies, Causality, Europe, Occupational Diseases, 030220 oncology & carcinogenesis, Sunlight, Female, MESH: Occupational Diseases, medicine.medical_specialty, MESH: Sunlight, Population, Job-exposure matrix, MESH: Causality, MESH: Pigmentation, Occupational medicine, 03 medical and health sciences, Mycosis Fungoides, Occupational Exposure, medicine, Humans, education, Aged, Mycosis fungoides, MESH: Humans, business.industry, MESH: Mycosis Fungoides, Public Health, Environmental and Occupational Health, Case-control study, Odds ratio, medicine.disease, Dermatology, Confidence interval, MESH: Odds Ratio, MESH: Male, Surgery, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Case-Control Studies, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Europe, business, MESH: Female
Abstract: International audience; OBJECTIVE: We sought to study the association between occupational sun exposure and mycosis fungoides (MF), a peripheral T-cell lymphoma. SUBJECTS AND METHODS: A European multicenter case-control study including seven rare cases (one being MF) was conducted between 1995 and 1997. From the 118 accepted cases, 104 were interviewed, of which 76 were definite cases. Population controls were selected randomly from the regions of case ascertainment. Information based on occupational experiences was coded according to industry types. A job exposure matrix was created according to the expected exposure to sunlight. RESULTS: Once exposures to aromatic halogenated hydrocarbons were eliminated (odds ratio = 2.3; 95% confidence interval = 0.9-6.2), a high MF risk was associated with exposures to solar radiation. CONCLUSION: It would appear that workers exposed to sunlight have a higher risk of MF. However, this factor is not the only one involved.
Published: 2006
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36. Survival in France after childhood acute leukaemia and non-Hodgkin's lymphoma (1990-2000)

Author: Marie-Françoise Auclerc, Denis Hémon, Catherine Patte, Anne Auvrignon, Jacqueline Clavel, Christophe Bergeron, A. Goubin, Secretariat, U754, Recherches épidémiologiques et statistiques sur l'environnement et la santé., Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Groupe FRALLE, Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), LMB, Institut Gustave Roussy (IGR), LMT, and Centre Léon Bérard [Lyon]
Subjects: Male, Cancer Research, Pediatrics, 0302 clinical medicine, MESH: Lymphoma, Non-Hodgkin, hemic and lymphatic diseases, MESH: Child, 030212 general & internal medicine, Child, education.field_of_study, Acute leukemia, Clinical Trials as Topic, Lymphoma, Non-Hodgkin, MESH: Clinical Trials, MESH: Infant, Newborn, Precursor Cell Lymphoblastic Leukemia-Lymphoma, MESH: Infant, 3. Good health, Childhood leukaemia, Survival Rate, MESH: Leukemia, Lymphocytic, Acute, L1, Oncology, 030220 oncology & carcinogenesis, Child, Preschool, Female, France, medicine.medical_specialty, Adolescent, MESH: Survival Rate, MESH: Clinical Trials as Topic, Population, Antineoplastic Agents, 03 medical and health sciences, medicine, Humans, education, Survival rate, MESH: Adolescent, MESH: Precursor Cell Lymphoblastic Leukemia-Lymphoma, MESH: Humans, business.industry, MESH: Child, Preschool, Infant, Newborn, Infant, MESH: Down Syndrome, medicine.disease, MESH: Male, Lymphoma, Non-Hodgkin's lymphoma, Clinical trial, MESH: France, El Niño, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Antineoplastic Agents, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Down Syndrome, business, MESH: Female
Abstract: International audience; This article describes the survival after childhood acute leukaemia (AL) and non-Hodgkin's lymphoma (NHL) of French population aged less than 15 years. The French National Registry of Childhood Leukaemia and Lymphoma recorded 3995 cases of acute lymphoblastic leukaemia (ALL), 812 of acute myeloid leukaemia (AML) and 1137 of NHL over the period from 1990 to 2000. Overall survival rates at 5 years were 82% (95% CI 80-83), 58% (95% CI 54-61) and 87% (95% CI 85-89) for ALL, AML and NHL, respectively. Survival after AL increased from 77% (95% CI 75-80) in 1990-1992 to 85% (95% CI 83-87) in 1997-2000 for ALL and from 47% (95% CI 41-54) to 61% (95% CI 55-67) for AML. Among AL cases, children aged 1-4 years had the most favourable prognosis. Down's syndrome was associated with poor survival after ALL. No gender-related variations in survival were in evidence. The results reported herein are similar to those reported by other European registries and clinical trials.
Published: 2006
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37. Childhood leukemia incidence and exposure to indoor radon, terrestrial and cosmic gamma radiation

Author: Eric Jougla, Denis Hémon, Margot Tirmarche, Anne-Sophie Evrard, Dominique Laurier, S. Billon, Jacqueline Clavel, Secretariat, U754, Epidémiologie environnementale des cancers, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de RadioBiologie et d'Epidémiologie (IRSN/DRPH/SRBE), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Centre d'épidémiologie sur les causes médicales de décès (CépiDc), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Radiobiologie et épidémiologie (DRPH/SRBE)
Subjects: Male, Epidemiology, Health, Toxicology and Mutagenesis, 030218 nuclear medicine & medical imaging, 0302 clinical medicine, Risk Factors, hemic and lymphatic diseases, MESH: Body Burden, MESH: Child, Relative biological effectiveness, Registries, MESH: Incidence, Child, MESH: Registrie, Leukemia, Radiation-Induced, Acute leukemia, Incidence, Incidence (epidemiology), Gamma ray, Confounding Factors, Epidemiologic, Environmental exposure, 3. Good health, Leukemia, Radon, Air Pollution, Indoor, Child, Preschool, 030220 oncology & carcinogenesis, Body Burden, Female, France, MESH: Radiation Dosage, Childhood leukemia, MESH: Environmental Exposure, chemistry.chemical_element, MESH: Leukemia, Radiation-Induced, MESH: Cosmic Radiation, Radiation Dosage, Risk Assessment, 03 medical and health sciences, Environmental health, medicine, Humans, Radiology, Nuclear Medicine and imaging, MESH: Humans, business.industry, MESH: Child, Preschool, MESH: Confounding Factors (Epidemiology), Environmental Exposure, MESH: Gamma Rays, medicine.disease, MESH: Male, MESH: France, chemistry, Gamma Rays, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Air Pollution, Indoor, Nuclear medicine, business, MESH: Radon, MESH: Female, Cosmic Radiation, Relative Biological Effectiveness
Abstract: This study was undertaken to evaluate the ecological association between terrestrial and cosmic gamma radiation, indoor radon, and acute leukemia incidence among children under 15 y of age. From 1990 to 2001, 5,330 cases of acute leukemia were registered by the French National Registry of Childhood Leukemia and Lymphoma. Exposure to terrestrial gamma radiation was based on measurements, using thermoluminescent dosimeters, at about 1,000 sites covering all the "Départements." In addition, 8,737 indoor terrestrial gamma dose rate measurements covering 62% of the "Départements" and 13,240 indoor radon concentration measurements covering all the "Départements" were made during a national campaign. Cosmic ray doses were estimated in each of the 36,363 "Communes" of France. There was no evidence of an ecological association between terrestrial gamma dose (range: 0.22-0.90 mSv y) or total gamma dose (range: 0.49-1.28 mSv y) and childhood acute leukemia incidence, for acute myeloid leukemia (AML) or for acute lymphoblastic leukemia (ALL), in univariate or multivariate regression analyses including indoor radon. A significant positive association between indoor radon (range: 22-262 Bq m) and AML incidence among children was observed and remained significant in multivariate regression analyses including either terrestrial gamma dose [SIR per 100 Bq m = 1.29 (1.09-1.53)] or total gamma dose [SIR per 100 Bq m = 1.29 (1.09-1.53)]. The study showed no ecological association between terrestrial gamma radiation and childhood leukemia for the range of variation in gamma dose rates observed in France. The moderate ecological association between childhood AML incidence and indoor radon does not appear to be confounded by terrestrial gamma dose.
Published: 2006
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38. Positive association between congenital anomalies and risk of neuroblastoma

Author: Pamela J. Reitnauer, Susan L. Cohn, Julie Blatt, Florence Menegaux, Andrew F. Olshan, Department of Epidemiology, University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC)-University of North Carolina System (UNC)-School of public health, The University of Hong Kong (HKU)-The University of Hong Kong (HKU), Recherches épidémiologiques et statistiques sur l'environnement et la santé., Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Pediatrics, University of North Carolina System (UNC)-University of North Carolina System (UNC)-School of Medicine, Pediatric Teaching Program, Moses Cone Health System, Northwestern University, and Secretariat, U754
Subjects: Adult, Male, Pediatrics, medicine.medical_specialty, Adolescent, Congenital Abnormalities, neuroblastoma, MESH: Child, Epidemiology, medicine, Humans, risk factors, Risk factor, MESH: Adolescent, child, MESH: Humans, Genitourinary system, business.industry, congenital anomalies, Confounding, MESH: Child, Preschool, Case-control study, Infant, MESH: Adult, MESH: Congenital Abnormalities, Hematology, Odds ratio, MESH: Neuroblastoma, MESH: Case-Control Studies, MESH: Infant, Confidence interval, MESH: Male, Oncology, El Niño, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Case-Control Studies, Child, Preschool, Pediatrics, Perinatology and Child Health, Female, epidemiology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Female
Abstract: Background Case reports and epidemiological studies have suggested a relationship between congenital anomalies and childhood cancer, but some potential associations remain inconsistent. In this study, we investigated the association between congenital anomalies and neuroblastoma. Procedure We used data of a case-control study on neuroblastoma conducted from 1992 to 1994, including 538 children aged 0–19 years with newly diagnosed, histologically confirmed neuroblastoma and 504 controls identified by telephone random-digit dialing and matched to cases on date of birth. Information on congenital anomalies and potential confounding factors was collected through maternal telephone interviews using a structured questionnaire. We estimated odds ratios (OR) and 95% confidence intervals (CI), adjusted for reference age at diagnosis, mother's educational level, mother's race, and household income at birth. Results An association between the maternal report of any congenital anomalies and neuroblastoma (OR = 2.58; CI = 1.57–4.25) was observed. Neuroblastoma risk increased with increasing number of anomalies per child (OR = 3.90, CI = 1.27–11.9 for two anomalies or more), and when we restricted analyses to major anomalies (OR = 7.53, CI = 2.23–25.5). Genitourinary anomalies (OR = 5.84, CI = 1.67–20.4) and cardiac anomalies (OR = 4.27, CI = 1.22–15.0) had an elevated, but imprecise neuroblastoma risk. Conclusions Our findings support the hypothesis of an association between neuroblastoma and congenital, especially urogenital and cardiac, anomalies. © 2004 Wiley-Liss, Inc.
Published: 2005
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39. Occupational risks for uveal melanoma results from a case-control study in nine European countries

Author: Ian A. Cree, Franco Merletti, Janine Bell, Lene Clausen, Mikael Eriksson, Ana Miranda, Aivars Stengrevics, Wolfgang Ahrens, Noemia Afonso, María Morales-Suárez-Varela, Lennart Hardell, Joelle Fevotte, Karl-Heinz Jöckel, Jean-Michel Lutz, Tine K. Kvist, Terri J. Ballard, Elsebeth Lynge, Svend Sabroe, Pascal Guénel, Diane Cyr, Secretariat, U754, Registre Genevois des Tumeurs, CHU Genève, Translational Oncology Research Centre, Queen Alexandra Hospital, Aarhus University [Aarhus], Department of Public Health [Copenhagen], Faculty of Health and Medical Sciences, University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH), Department of Biostatistics and Medical Informatics, Universidade do Porto = University of Porto, Bremen Institute for Prevention Research and Social Medicine, The Venetian Tumour Registry, Hôpital de Padoue, Thames Cancer Registry, Hôpital Londres, Santé publique et épidémiologie des déterminants professionnels et sociaux de la santé, Epidémiologie, sciences sociales, santé publique (IFR 69), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Oncology, Lund University Hospital, Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement UMRT9002 (UMRESTTE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche sur les Transports et leur Sécurité (INRETS)-Institut de Veille Sanitaire (INVS), Recherches épidémiologiques et statistiques sur l'environnement et la santé., Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Örebro University Hospital [Örebro, Sweden], University Clinics of Essen, University of Essen, Southern Portugal Cancer Registry, Instituto Português de Oncologia, Unit of Cancer Epidemiology, Université de Turin-CERMS and Centre for Oncologic Prevention, Unit of Public Health and Environmental Care, Universitat de València (UV), Latvia Cancer Register, Latvia Oncology Centre, University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), Universidade do Porto, Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Université de Valence, Institut National de Recherche sur les Transports et leur Sécurité (INRETS)-Institut de Veille Sanitaire (INVS)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon
Subjects: Male, Uveal Neoplasms, Cancer Research, Medizin, Uveal Neoplasm, MESH: Risk Assessment, MESH: Occupational Exposure, 0302 clinical medicine, Reference Values, Epidemiology, Medicine, MESH: Incidence, Melanoma, MESH: Aged, MESH: Middle Aged, Incidence (epidemiology), Incidence, MESH: Sex Distribution, MESH: Reference Values, MESH: Confidence Intervals, Middle Aged, Prognosis, eye, MESH: Case-Control Studies, 3. Good health, Europe, Occupational Diseases, Oncology, 030220 oncology & carcinogenesis, MESH: Survival Analysis, Sunlight, Female, Risk assessment, MESH: Occupational Diseases, Adult, medicine.medical_specialty, MESH: Sunlight, MESH: Melanoma, Ultraviolet Rays, malignant melanoma, Case-control Study, Risk Assessment, MESH: Prognosis, 03 medical and health sciences, Age Distribution, Occupational Exposure, Confidence Intervals, Humans, Sex Distribution, MESH: Age Distribution, Aged, MESH: Humans, business.industry, Public health, Case-control study, MESH: Adult, Dermatology, Survival Analysis, eye diseases, MESH: Male, Surgery, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Case-Control Studies, 030221 ophthalmology & optometry, Etiology, MESH: Ultraviolet Rays, MESH: Uveal Neoplasms, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, sense organs, MESH: Europe, business, MESH: Female, Rare disease
Abstract: International audience; OBJECTIVE: Uveal melanoma is a rare disease with poor prognosis and largely unknown etiology. We studied potential occupational risk factors. METHODS: A population based case-control study was undertaken during 1995-1997 in nine European countries using population and colon cancer controls with personal interviews. Occupational exposure to sunlight and artificial UV radiation was assessed with a job exposure matrix. In total, 320 uveal melanoma cases were eligible at pathology review, and 292 cases were interviewed, participation 91%. Out of 3357 population controls, 2062 were interviewed, 61%, and out of 1272 cancer controls 1094 were interviewed, 86%. RESULTS: Using population controls, occupational exposure to sunlight was not associated with an increased risk (RR=1.24, 95% CI=0.88-1.74), while an excess risk found with use of colon cancer controls was attributed to confounding factors. An excess risk in welders was restricted to the French part of the data. Cooks, RR=2.40; cleaners, RR 2.15; and laundry workers, RR=3.14, were at increased risk of uveal melanoma. CONCLUSION: Our study does overall not support an association between occupational sunlight exposure and risk of uveal melanoma. The finding of an excess risk of eye melanoma in cooks in several European countries is intriguing.
Published: 2005
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40. [Contribution of national paediatric cancer registries to survey and research]

Author: D, Sommelet, J, Clavel, B, Lacour, Secretariat, U754, Service d'oncohématologie pédiatrique, and CHU-Hôpital d'enfants
Subjects: Biomedical Research, MESH: Humans, MESH: Registries, Data Collection, MESH: Biomedical Research, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Neoplasms, MESH: Child, Humans, MESH: Data Collection, MESH: Neoplasms, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Public Health, Registries, Child, MESH: Public Health, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2005
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41. Polycyclic aromatic hydrocarbons and fatal ischemic heart disease

Author: Burstyn, I., Kromhout, H., Partanen, T.J., Svane, O., Langard, S., Ahrens, W., Kauppinen, T., Stucker, I., Shaham, J., Heederik, D.J.J., Ferro, G., Heikkila, P., Hooiveld, M., Johansen, C., Randem, B., Boffetta, P., Faculteit Diergeneeskunde, Secretariat, U754, Unit of Environment Cancer Epidemiology, IARC, Division of Occupational and Environmental Health, Institute for Risk Assessment (IRAS), Utrecht University [Utrecht], Department of Public Health Sciences, University of Alberta, Unit of Excellence for Psychosocial Factors, Finnish Institute of Occupational Health, Central American Institute for Studies on Toxic Substances, Universidad National, Danish Working Environment Service, Centre for Occupational and Environmental Medicine, Riskhospitalet University Hospital, Bremen Institute for Prevention Research and Social Medicine, Recherches épidémiologiques et statistiques sur l'environnement et la santé., Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Occupational Cancer Department, National Institute of Occupational and Environmental Health, Institute of Cancer Epidemiology, Danish Cancer Society, Burstyn, I., Kromhout, H., Partanen, T., Svane, O., Langård, S., Ahrens, W., Kauppinen, T., Stücker, I., Shaham, J., Heederik, D., Ferro, G., Heikkila, P., Hooiveld, M., Johansen, C., Randem, B.G., Boffetta, P., and Faculteit Diergeneeskunde
Subjects: Male, Epidemiology, Denmark, Myocardial Ischemia, MESH: Occupational Exposure, MESH: Cause of Death, chemistry.chemical_compound, Risk Factors, MESH: Risk Factors, Cause of Death, Germany, Determinants in Health and Disease [EBP 1], Israel, Polycyclic Aromatic Hydrocarbons, Finland, MESH: Finland, Confounding, Smoking, Absolute risk reduction, MESH: Israel, Confounding Factors, Epidemiologic, Occupational Diseases, Cohort, Benzopyrene, MESH: Myocardial Ischemia, France, MESH: Occupational Diseases, medicine.medical_specialty, MESH: Smoking, Ischemic heart disease, Coronacrisis-Taverne, Occupational medicine, MESH: Polycyclic Hydrocarbons, Aromatic, Interventional oncology [UMCN 1.5], Environmental health, Occupational Exposure, medicine, Humans, cardiovascular diseases, Risk factor, MESH: Germany, MESH: Denmark, MESH: Humans, business.industry, MESH: Confounding Factors (Epidemiology), MESH: Male, MESH: France, chemistry, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Relative risk, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business
Abstract: Background: Several toxicologic and epidemiologic studies have produced evidence that occupational exposure to polycyclic aromatic hydrocarbons (PAH) is a risk factor for ischemic heart disease (IHD). However, a clear exposure-response relation has not been demonstrated. Methods: We studied a relation between exposure to PAH and mortality from IHD (418 cases) in a cohort of 12,367 male asphalt workers from Denmark, Finland, France, Germany, Israel, The Netherlands and Norway. The earliest follow up (country-specific) started in 1953 and the latest ended in 2000, averaging 17 years. Exposures to benzo(a)pyrene were assessed quantitatively using measurement-driven exposure models. Exposure to coal tar was assessed in a semiquantitative manner on the basis of information supplied by company representatives. We carried out sensitivity analyses to assess potential confounding by tobacco smoking. Results: Both cumulative and average exposure indices for benzo(a)pyrene were positively associated with mortality from IHD. The highest relative risk for fatal IHD was observed for average benzo(a)pyrene exposures of 273 ng/m 3 or higher, for which the relative risk was 1.64 (95% confidence interval = 1.13-2.38). Similar results were obtained for coal tar exposure. Sensitivity analysis indicated that even in a realistic scenario of confounding by smoking, we would observe approximately 20% to 40% excess risk in IHD in the highest PAH-exposure categories. Conclusions: Our results lend support to the hypothesis that occupational PAH exposure causes fatal IHD and demonstrate a consistent exposure-response relation for this association. Copyright © 2005 by Lippincott Williams & Wilkins.
Published: 2005

42. Collection of human genomic DNA from buccal cells for genetics studies: comparison between cytobrush, mouthwash, and treated card

Author: Jacqueline Clavel, Isabelle Stücker, Marie-Anne Loriot, Claire Mulot, Philippe Beaune, Toxicologie Moleculaire (U490), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Recherches épidémiologiques et statistiques sur l'environnement et la santé., Institut National de la Santé et de la Recherche Médicale (INSERM), This work is supported by La Ligue Nationale Contre le Cancer (Comit'e de Paris), the Association pour la Recherche Contre le Cancer, and the Conseil R'egional d'Ile-de-France., Secretariat, U754, Toxicologie Moleculaire, Université Paris Descartes - Paris 5 (UPD5) - Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM) - Institut National de la Santé et de la Recherche Médicale (INSERM), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Article Subject, lcsh:Biotechnology, Health, Toxicology and Mutagenesis, Buccal swab, lcsh:Medicine, law.invention, chemistry.chemical_compound, stomatognathic system, law, lcsh:TP248.13-248.65, [SDV.SPEE] Life Sciences [q-bio]/Public Health and Epidemiology, Genetics, Medicine, Molecular Biology, Polymerase chain reaction, business.industry, lcsh:R, Dna concentration, General Medicine, Buccal administration, genomic DNA, chemistry, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Molecular Medicine, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Sample collection, business, DNA, Biotechnology, Research Article
Abstract: Alternative sources such as buccal cells have already been tested for genetic studies and epidemiological investigations. Thirty-seven volunteers participated in this study to compare cytology brushes, mouthwash, and treated cards for DNA collection. Quantity and quality of DNA and cost and feasibility were assessed. The mean DNA yield at 260 nm was found to be3.5,4, and2.6μg for cytobrushes, mouthwashes, and treated cards, respectively. A second quantification technique by fluorescence showed differences in the DNA yield with1.1and5.2μg for cytobrushes and mouthwash, respectively. All buccal samples allowed isolation of DNA suitable for polymerase chain reaction. According to the procedure of sample collection, the yield and purity of collected DNA, and storage conditions, the use of cytobrush appears to be the more appropriate method for DNA collection. This protocol has been validated and is currently applied in three large-scale multicentric studies including adults or children.
Published: 2005
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43. Cancer incidence among children in France, 1990-1999

Author: François Demeocq, Piotr Gembara, Emmanuel Desandes, Fernand Freycon, Jacqueline Clavel, Brigitte Lacour, Isabelle Tron, Lionel de Lumley, Claire Berger, P. Blouin, Jean-Louis Bernard, Pascale Pillon, Edouard Le Gall, Danièle Sommelet, A. Goubin, Registre National des Tumeurs Solides de l'Enfant (RNTSE), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Cancéropôle du Grand Est, Registre des Cancers de l'Enfant de Lorraine, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Registre National des Hémopathies malignes de l'Enfant (RNHE), Institut de Veille Sanitaire (INVS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Registre des Cancers du Val-de-Marne, Institut de Veille Sanitaire (INVS), Registre des Cancers de l'Enfant de Rhônes-Alpes, CHU Saint Etienne, Registre des cancers de l'enfant de PACA-Corse, Assistance Publique - Hôpitaux de Marseille (APHM), Registre des Cancers de l'Enfant d'Auvergne-Limousin, CHU Clermont-Ferrand, Registre des Cancers de l'Enfant de Bretagne, and Secretariat, U754
Subjects: Male, Pediatrics, MESH: Registries, 0302 clinical medicine, Neoplasms, MESH: Child, Epidemiology, MESH: Neoplasms, Registries, MESH: Incidence, Child, Cause of death, MESH: Time, Incidence, Incidence (epidemiology), MESH: Infant, Newborn, Age Factors, Hematology, MESH: Infant, Annual Percent Change, 3. Good health, Oncology, Child, Preschool, 030220 oncology & carcinogenesis, Female, France, Adult, medicine.medical_specialty, Adolescent, Time, 03 medical and health sciences, Sex Factors, MESH: Sex Factors, 030225 pediatrics, Incidence trends, medicine, Humans, MESH: Adolescent, MESH: Age Factors, MESH: Humans, business.industry, MESH: Child, Preschool, Infant, Newborn, Infant, Cancer, MESH: Adult, medicine.disease, MESH: Male, MESH: France, Cancer incidence, El Niño, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Pediatrics, Perinatology and Child Health, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Female
Abstract: Background Cancer is the second most important cause of death for children aged less than 15 years in France, unintentional injuries being the leading cause. The aim of the present study was to estimate the incidence of childhood cancer from six Childhood Cancer Registries covering 32% of France. Procedure Incident cancer cases diagnosed between 1990 and 1999 in children (0–14 years) resident in the administrative areas covered by each Registry were included. Annual age-standardized rates (ASRs) were adjusted by the world population. The estimated annual percent change (EAPC) was used to measure trend towards changes in the annual age-standardized incidence rate. Results With 4234 registered cases, the ASRs per million children were 137.5 for all cancers combined, 42.3 for leukemia, 29.1 for central-nervous-system tumors, 15.6 for lymphomas, 14.1 for sympathetic-nervous-system tumors, and 9.1 for renal tumors. The ASR of all cancers combined was slightly higher in males (145.8 per million children) than in females (128.7 per million children) with an M/F ratio of 1.2. No significant incidence trend was observed, with an EAPC of +0.2% [IC 95% (−2.5; +3.0); P = 0.89]. Conclusions The estimated incidence rates are similar to those reported in previous studies in European and North American countries. These results will contribute to the development of National Registration of Childhood Cancer in France and support the national research program on childhood cancer. © 2004 Wiley-Liss, Inc.
Published: 2004
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44. [The heat wave in France in August 2003]

Author: Hémon, Denis, Jougla, Eric, Recherches épidémiologiques et statistiques sur l'environnement et la santé., Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d'épidémiologie sur les causes médicales de décès (CépiDc), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Secretariat, U754
Subjects: Male, Hot Temperature, Time Factors, Fever, Infrared Rays, Heat Stroke, MESH: Heat, MESH: Heat Stroke, MESH: Risk Factors, Risk Factors, MESH: Fever, Humans, Mortality, Aged, MESH: Aged, MESH: Dehydration, MESH: Humans, MESH: Mortality, Dehydration, MESH: Time Factors, MESH: Male, MESH: France, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Female, France, MESH: Infrared Rays, MESH: Female
Published: 2004

45. Association of polymorphisms in the Tau and Saitohin genes with Parkinson's disease

Author: Jacqueline Clavel, Christophe Tzourio, P. Amouyel, Jean-Sébastien Vidal, C Levecque, Marie-Christine Chartier-Harlin, Annick Alpérovitch, Alexis Elbaz, Epidémiologie des maladies chroniques: impact des intéractions gène environnement sur la santé des populations, Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Recherches épidémiologiques en neurologie et psychopathologie, Institut National de la Santé et de la Recherche Médicale (INSERM), Recherches épidémiologiques et statistiques sur l'environnement et la santé., Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de neurologie [Saint-Antoine], Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), The study was supported by the INSERM, the Institut Pasteur de Lille, the MSA, and the French Ministry of the Environment. CL is a recipient of the Ministère de la Recherche et de la Technologie., We thank all the MSA (Mutualité Sociale Agricole) physicians who interviewed the participants and the MSA employees who helped with the coordination of the study. Drs David Gervais and Lamia Benslamia participated in the examination of Parkinson’s disease patients. Mrs Chantal Cordelier and Drs Carline Amiel, Frédérique Brunner, and Jean-Philippe Galanaud helped with the assessment of exposure to pesticides. Dr Safia Zenagui participated in the coordination of the study. We thank Prakash Rucktooa, Aurélie Melchior, Xavier Hermant, and Vincent Mouroux for their technical assistance., Service de neurologie [CHU Saint-Antoine], and Secretariat, U754
Subjects: Male, Candidate gene, Parkinson's disease, Short Report, tau Proteins, Locus (genetics), Biology, 03 medical and health sciences, 0302 clinical medicine, Degenerative disease, MESH: Polymorphism, Genetic, Odds Ratio, medicine, Humans, Genetic Predisposition to Disease, Allele, Aged, 030304 developmental biology, Genetics, MESH: Aged, 0303 health sciences, Polymorphism, Genetic, MESH: Humans, MESH: Middle Aged, Haplotype, Case-control study, MESH: Genetic Predisposition to Disease, Parkinson Disease, Odds ratio, MESH: Haplotypes, Middle Aged, medicine.disease, MESH: Case-Control Studies, MESH: Odds Ratio, MESH: Male, MESH: tau Proteins, Psychiatry and Mental health, Haplotypes, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Case-Control Studies, Female, Surgery, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Neurology (clinical), MESH: Female, 030217 neurology & neurosurgery, MESH: Parkinson Disease
Abstract: International audience; BACKGROUND: The Saitohin gene has recently been identified in intron 9 of the Tau gene. Because an association between Parkinson's disease and Tau has been described, Saitohin represents a candidate gene for Parkinson's disease. OBJECTIVE: To test these two genes for their association with Parkinson's disease in a large community based case-control study. RESULTS: Cases (n = 208) were more often homozygotes for the Tau H1 haplotype than controls (n = 483; odds ratio (OR) = 1.71 (95% confidence interval, 1.20 to 2.43); p = 0.003), and the saitohin Q allele was in complete linkage disequilibrium with the H1 haplotype. This association was stronger among cases with Parkinson's disease onset below 65 years (< or =65 years: OR = 2.52 (1.49 to 4.25); p65 years: OR = 1.20 (0.73 to 1.98); p
Published: 2004
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46. CYP2D6 polymorphism, pesticide exposure, and Parkinson's disease

Author: Elbaz, Alexis, Levecque, Clotilde, Clavel, Jacqueline, Vidal, Jean-Sébastien, Richard, Florence, Amouyel, Philippe, Alpérovitch, Annick, Chartier-Harlin, Marie-Christine, Tzourio, Christophe, Recherches épidémiologiques en neurologie et psychopathologie, Institut National de la Santé et de la Recherche Médicale (INSERM), Epidémiologie des maladies chroniques: impact des intéractions gène environnement sur la santé des populations, Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Recherches épidémiologiques et statistiques sur l'environnement et la santé., Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de neurologie [Saint-Antoine], Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Secretariat, U754, and Service de neurologie [CHU Saint-Antoine]
Subjects: MESH: Adolescent, MESH: Aged, MESH: Humans, MESH: Middle Aged, MESH: Environmental Exposure, MESH: Genetic Predisposition to Disease, MESH: Adult, MESH: Polymerase Chain Reaction, MESH: Case-Control Studies, MESH: Male, MESH: Occupational Exposure, MESH: Cytochrome P-450 CYP2D6, MESH: Cross-Sectional Studies, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Polymorphism, Genetic, MESH: Gene Frequency, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Pesticides, MESH: Female, MESH: Parkinson Disease, MESH: Prevalence
Abstract: International audience; We performed a case-control study of Parkinson's disease (PD) in a population characterized by a high prevalence of pesticide exposure and studied the joint effect of pesticide exposure and CYP2D6. Although they are based on a small group of subjects with the joint exposure, our findings are consistent with a gene-environment interaction disease model according to which (1) pesticides have a modest effect in subjects who are not CYP2D6 poor metabolizers, (2) pesticides' effect is increased in poor metabolizers (approximately twofold), and (3) poor metabolizers are not at increased PD risk in the absence of pesticide exposure.
Published: 2004
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47. Acute childhood leukaemia and environmental exposure to potential sources of benzene and other hydrocarbons; a case-control study

Author: André Baruchel, Anne Lambilliotte, Etienne Vilmer, K Kebaili, Jacqueline Clavel, Danièle Sommelet, C Steffen, Guy Leverger, Denis Hémon, Marie-Françoise Auclerc, Anne Auvrignon, Secretariat, U754, Recherches épidémiologiques et statistiques sur l'environnement et la santé., Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'hématologie pédiatrique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service d'hématologie-immunologie-oncologie pédiatrique [CHU Trousseau], Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Service d'hématologie : Immuno-Hématologie pédiatrique et transplantation de moelle osseuse, Hôpital Debrousse, Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Service d'hématologie pédiatrique-oncologie, Hôpital Jeanne de Flandre [Lille], Service d'Hématologie Pédiatrique [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Service d'hématologie et immunologie pédiatrique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 (UPD7), Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)
Subjects: Male, MESH: Benzene, 010501 environmental sciences, 01 natural sciences, 0302 clinical medicine, Residence Characteristics, hemic and lymphatic diseases, MESH: Child, Epidemiology, Odds Ratio, Medicine, hydrocarbons, MESH: Residence Characteristics, MESH: Maternal Exposure, Child, Confounding, MESH: Infant, Newborn, Environmental exposure, Precursor Cell Lymphoblastic Leukemia-Lymphoma, MESH: Case-Control Studies, MESH: Infant, MESH: Leukemia, Lymphocytic, Acute, L1, Maternal Exposure, 030220 oncology & carcinogenesis, Child, Preschool, leukaemia, Original Article, Female, epidemiology, France, environment, medicine.medical_specialty, MESH: Environmental Exposure, Occupational medicine, 03 medical and health sciences, Acute lymphocytic leukemia, Environmental health, MESH: Hydrocarbons, Humans, 0105 earth and related environmental sciences, childhood, Pregnancy, MESH: Humans, business.industry, MESH: Child, Preschool, Public Health, Environmental and Occupational Health, Case-control study, Infant, Newborn, Infant, Benzene, Odds ratio, Environmental Exposure, medicine.disease, MESH: Male, MESH: Odds Ratio, MESH: France, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Case-Control Studies, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Female
Abstract: Aim: To analyse the association between potential environmental exposure to hydrocarbons and the risk of acute childhood leukaemia. Methods: A hospital based multicentre case control study, stratified on centre, age, and sex, with 280 leukaemia cases and 285 controls was carried out. Data were collected by a standardised interview of the mothers. Results: No clear association was seen between maternal occupational exposure to hydrocarbons during pregnancy and leukaemia, or between residential traffic density and leukaemia. There was an association between dwellings neighbouring a petrol station or a repair garage during childhood and the risk of childhood leukaemia (OR 4.0, 95% CI 1.5 to 10.3), with a duration trend. The association, which appeared particularly strong for acute non-lymphocytic leukaemia (OR 7.7, 95% CI 1.7 to 34.3), was not altered by adjustment for potential confounding factors. Conclusions: Results showed an association between acute childhood leukaemia and dwellings neighbouring auto repair garages and petrol stations, which are benzene emitting sources. These findings could be due to chance, although the strength of the association and the duration trend are arguments for a causal association.
Published: 2004
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48. Risk of fatal industrial accidents and death from other external causes among asphalt workers

Author: Burstyn, I., Boffetta, P., Jarvholm, B., Partanen, T., Svane, O., Langard, S., Kauppinen, T., Stucker, I., Shaham, J., Heederik, D., Ahrens, W., Bergdahl, I., Cenee, S., Hooiveld, M., Randem, Bg, christoffer johansen, Ferro, G., Kromhout, H., Division of Occupational and Environmental Health, Institute for Risk Assessment (IRAS), Utrecht University [Utrecht], Unit of Environment Cancer Epidemiology, IARC, Occupational Medicine, Department of Public Health and Clinical Medicine, Umea University Hospital, Unit of Excellence for Psychosocial Factors, Finnish Institute of Occupational Health, Danish Working Environment Service, Centre for Occupational and Environmental Medicine, Riskhospitalet University Hospital, Recherches épidémiologiques et statistiques sur l'environnement et la santé., Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Occupational Cancer Department, National Institute of Occupational and Environmental Health, Bremen Institute for Prevention Research and Social Medicine, Institute of Cancer Epidemiology, Danish Cancer Society, Secretariat, U754, Universiteit Utrecht, Faculteit Diergeneeskunde, Burstyn, I., Boffetta, P., Järvholm, B., Partanen, T., Svane, O., Langård, S., Kauppinen, T., Stücker, I., Shaham, J., Heederik, D., Ahrens, W., Bergdahl, I., Cenée, S., Hooiveld, M., Randem, B.G., Johansen, C., Ferro, G., and Kromhout, H.
Subjects: Adult, Male, MESH: Accidents, Traffic, Time Factors, Risk fatal industrial accidents death external causes asphalt workers, Coronacrisis-Taverne, Short Report, MESH: Risk Assessment, Risk Assessment, MESH: Cause of Death, Cohort Studies, Interventional oncology [UMCN 1.5], MESH: Accidents, Occupational, Cause of Death, MESH: Hydrocarbons, Determinants in Health and Disease [EBP 1], Accidents, Occupational, Humans, MESH: Cohort Studies, MESH: Humans, MESH: Middle Aged, MESH: Time Factors, Accidents, Traffic, MESH: Adult, Middle Aged, MESH: Male, Hydrocarbons, Europe, Suicide, MESH: Suicide, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Europe
Abstract: Item does not contain fulltext The hypothesis that asphalt workers are at increased risk of mortality from industrial accidents and other external causes was tested. Mortality rates for external and violent causes of death in a cohort of asphalt industry employees from seven European countries and Israel were compared to that of the general population. There was no evidence that mortality from external causes was increased among long term employees in asphalt application and mixing. There was an increased risk for mortality due to external causes among short term workers. However, none of the fatal accidents among short term workers appear to have occurred during employment in the studied asphalt companies. Overall, no evidence was found supporting the hypothesis that asphalt workers are at increased risk of fatal industrial or road accidents. Mortality from other external causes did not increase in this population as a whole, but increased risks among short term workers deserve further attention.
Published: 2003

49. Structure and polymorphisms of human aryl hydrocarbon receptor repressor (AhRR) gene in a French population: relationship with CYP1A1 inducibility and lung cancer

Author: Cauchi, Stéphane, Stücker, Isabelle, Cénée, Sylvie, Kremers, Pierre, Beaune, Philippe, Massaad-Massade, Liliane, Toxicologie Moleculaire, Université Paris Descartes - Paris 5 (UPD5) - Institut National de la Santé et de la Recherche Médicale (INSERM), Recherches épidémiologiques et statistiques sur l'environnement et la santé., Institut National de la Santé et de la Recherche Médicale (INSERM) - Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Pathologie, CHU Liège, Secretariat, U754, Toxicologie Moleculaire (U490), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Lung Neoplasms, MESH: Enzyme Induction, Genotype, MESH: Genotype, MESH: Polymorphism, Genetic, [SDV.SPEE] Life Sciences [q-bio]/Public Health and Epidemiology, Basic Helix-Loop-Helix Transcription Factors, Cytochrome P-450 CYP1A1, Humans, Genetic Predisposition to Disease, Lymphocytes, Polymorphism, Genetic, MESH: Humans, MESH: Genetic Predisposition to Disease, respiratory system, MESH: Lung Neoplasms, Repressor Proteins, MESH: France, MESH: Cytochrome P-450 CYP1A1, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Repressor Proteins, Enzyme Induction, MESH: 5' Untranslated Regions, MESH: Lymphocytes, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, 5' Untranslated Regions
Abstract: International audience; OBJECTIVE: The aryl hydrocarbon receptor repressor (AhRR) protein may dimerize with the AhR nuclear translocator (ARNT) and may compete with the aryl hydrocarbon receptor (AhR) to bind the xenobiotic responsive elements. The result is a negative feedback mechanism that involves a down regulation of all genes regulated by the AhR transcription factor which positively regulates the expression of the Cytochrome P-4501A1 gene (CYP1A1). METHODS: The structure of the AhRR gene was reconstituted, then the genetic polymorphisms of this gene including the promoter were investigated and the link between these polymorphisms, CYP1A1 inducibility and lung cancer incidence in a French population was examined. Four polymorphisms were found, two in the coding region (609G>C and 1977G>C) and two in the 5'-untranslated region (-96G>A and -869A>T). Among the four polymorphisms, only one, the 609G>C has been previously described. The 609G>C and 1977G>C are localized respectively in exon 6 and 12 and lead to Pro554Ala and Asp641His substitutions, respectively. To evaluate the frequency of these allelic variants, a DNA library of a case-control study of lung cancer (164 controls and 171 patients) was screened. These polymorphisms were detected at the same allele frequency (0.40 for 609C, 0.05 for 1977C, 0.24 for -96A and 0.17 for -869T) in both controls and patients. Statistical analysis did not show any relationship between all the mutations found and CYP1A1 inducibility and lung cancer incidence. CONCLUSION: None of the polymorphisms were found to play a key role in CYP1A1 inducibility or in the susceptibility to develop lung cancer.
Published: 2003
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50. Polymorphisms in CYP1A1, GSTM1, GSTT1 and lung cancer below the age of 45 years

Author: Dorota Butkiewicz, Ari Hirvonen, Emanuelle Taioli, Marjorie Romkes, Laura Gaspari, Ivan Kalina, Seymour Garte, Stephanie J. London, Pierre Kremers, Aage Haugen, Agneta Rannug, Paolo Boffetta, Simone Benhamou, Janeric Seidegård, Ingolf Cascorbi, Richard C. Strange, Jürgen Brockmöller, Loic Le Marchand, Vita Dolzan, Jordi To-Figueras, Isabelle Stücker, Bernadette Schoket, Margie L. Clapper, Kirsti Husgafvel-Pursiainen, Molecular and Genetic Epidemiology Unit (IRCCS), IRCCS, Unité de Recherches en Epidémiologie des Cancers, Institut National de la Santé et de la Recherche Médicale (INSERM), Unit of Environment Cancer Epidemiology, IARC, Institute of Clinical Pharmacology, Georg-August-University [Göttingen], Institute of Clinical Pharmacology of Gliwice, Ernst Moritz Arndt University, Fox Chase Cancer Centre, University of Ljubljana, National Institue of Occupational Health, National Institue of Occupational Health of Norway, Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Unit of Excellence for Psychosocial Factors, P.J. Safarik University, Institut de Pathologie, CHU Liège, University of Hawai‘i [Mānoa] (UHM), National Institute for Environmental Health Sciences Research Triangle Park, Karolinska Institutet [Stockholm], Department of Computer Science - University of Pittsburgh, University of Pittsburgh (PITT), Pennsylvania Commonwealth System of Higher Education (PCSHE)-Pennsylvania Commonwealth System of Higher Education (PCSHE), National Institute of Environmental Health, Lund University [Lund], Keele University [Keele], Recherches épidémiologiques et statistiques sur l'environnement et la santé., Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hospital Clinic Provincial, Environmental and Occupational Health Sciences Institute (EOHSI), EOHSI, Georg-August-University = Georg-August-Universität Göttingen, and Secretariat, U754
Subjects: Oncology, Male, Lung Neoplasms, MESH: Chi-Square Distribution, Databases, Factual, Epidemiology, 0302 clinical medicine, Risk Factors, MESH: Risk Factors, Genotype, Medicine, Young adult, Age of Onset, Glutathione Transferase, 0303 health sciences, Respiratory disease, Smoking, MESH: Genetic Predisposition to Disease, General Medicine, respiratory system, MESH: Case-Control Studies, 3. Good health, MESH: Cytochrome P-450 CYP1A1, 030220 oncology & carcinogenesis, Female, Adult, medicine.medical_specialty, MESH: Smoking, MESH: Age of Onset, MESH: Factor Analysis, Statistical, Genetic determinism, 03 medical and health sciences, Internal medicine, MESH: Polymorphism, Genetic, Genetic predisposition, Cytochrome P-450 CYP1A1, Humans, Genetic Predisposition to Disease, Lung cancer, Carcinogen, 030304 developmental biology, MESH: Glutathione Transferase, Chi-Square Distribution, Polymorphism, Genetic, MESH: Humans, business.industry, MESH: Adult, medicine.disease, MESH: Databases, Factual, MESH: Male, respiratory tract diseases, MESH: Lung Neoplasms, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Case-Control Studies, Immunology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Factor Analysis, Statistical, MESH: Female
Abstract: Background A genetic component of early-onset lung cancer has been suggested. The role of metabolic gene polymorphisms has never been studied in young lung cancer cases. Phase 1 and Phase 2 gene polymorphisms are involved in tobacco carcinogens' metabolism and therefore in lung cancer risk. Methods The effect of metabolic gene polymorphisms on lung cancer at young ages was studied by pooling data from the Genetic Susceptibility to Environmental Carcinogens (GSEC) database. All primary lung cancer cases of both sexes who were Caucasian and less than or equal to45 years of age at diagnosis, and the corresponding controls were selected. We obtained 261 cases and 1452 controls. Results There was a marginally significant association between lung cancer and GST1 null genotype (OR = 1.2; 95% Cl: 1.0-1.6), and a significant association between lung cancer and the homozygous CYP1A1 Msp1 variant allele (CYP1A1*2A and *2B) genotype (OR = 4.7 95% Cl: 1.2-19.0). When data were stratified by smoking status, the association between CYP1A1 genotype and lung cancer was confined to never smokers. Conclusions These results suggest that metabolic genetic factors play a role in lung cancer developing at young ages. (Less)
Published: 2003

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