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1. Late Afternoon Vigorous Exercise Increases Postmeal but Not Overnight Hypoglycemia in Adults with Type 1 Diabetes Managed with Automated Insulin Delivery

Author

Morrison, Dale, primary, Paldus, Barbora, additional, Zaharieva, Dessi P., additional, Lee, Melissa H., additional, Vogrin, Sara, additional, Jenkins, Alicia J., additional, Gerche, André La, additional, MacIsaac, Richard J., additional, McAuley, Sybil A., additional, Ward, Glenn M., additional, Colman, Peter G., additional, Smart, Carmel E.M., additional, Seckold, Rowen, additional, Grosman, Benyamin, additional, Roy, Anirban, additional, King, Bruce R., additional, Riddell, Michael C., additional, and O'Neal, David Norman, additional

Published
2022
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3. A Randomized Crossover Trial Comparing Glucose Control During Moderate-Intensity, High-Intensity, and Resistance Exercise With Hybrid Closed-Loop Insulin Delivery While Profiling Potential Additional Signals in Adults With Type 1 Diabetes

Author

Paldus, Barbora, primary, Morrison, Dale, primary, Zaharieva, Dessi P., primary, Lee, Melissa H., primary, Jones, Hannah, primary, Obeyesekere, Varuni, primary, Lu, Jean, primary, Vogrin, Sara, primary, Gerche, André La, primary, McAuley, Sybil A., primary, MacIsaac, Richard J, primary, Jenkins, Alicia J., primary, Ward, Glenn M., primary, Colman, Peter, primary, Smart, Carmel, primary, Seckold, Rowen, primary, King, Bruce, primary, Riddell, Michael C., primary, and O’Neal, David N., primary

Published
2021
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4. Restricted AccessA Randomized Crossover Trial Comparing Glucose Control During Moderate-Intensity, High-Intensity, and Resistance Exercise With Hybrid Closed-Loop Insulin Delivery While Profiling Potential Additional Signals in Adults With Type 1 Diabetes

Author

Paldus, Barbora, primary, Morrison, Dale, primary, Zaharieva, Dessi P., primary, Lee, Melissa H., primary, Jones, Hannah, primary, Obeyesekere, Varuni, primary, Lu, Jean, primary, Vogrin, Sara, primary, Gerche, André La, primary, McAuley, Sybil A., primary, MacIsaac, Richard J, primary, Jenkins, Alicia J., primary, Ward, Glenn M., primary, Colman, Peter, primary, Smart, Carmel, primary, Seckold, Rowen, primary, King, Bruce, primary, Riddell, Michael C., primary, and O’Neal, David N., primary

Published
2021
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5. Long-Term Efficacy of T3 Analogue Triac in Children and Adults With MCT8 Deficiency: A Real-Life Retrospective Cohort Study

Author

van Geest, Ferdy S, primary, Groeneweg, Stefan, additional, van den Akker, Erica L T, additional, Bacos, Iuliu, additional, Barca, Diana, additional, van den Berg, Sjoerd A A, additional, Bertini, Enrico, additional, Brunner, Doris, additional, Brunetti-Pierri, Nicola, additional, Cappa, Marco, additional, Cappuccio, Gerarda, additional, Chatterjee, Krishna, additional, Chesover, Alexander D, additional, Christian, Peter, additional, Coutant, Régis, additional, Craiu, Dana, additional, Crock, Patricia, additional, Dewey, Cheyenne, additional, Dica, Alice, additional, Dimitri, Paul, additional, Dubey, Rachana, additional, Enderli, Anina, additional, Fairchild, Jan, additional, Gallichan, Jonathan, additional, Garibaldi, Luigi R, additional, George, Belinda, additional, Hackenberg, Annette, additional, Heinrich, Bianka, additional, Huynh, Tony, additional, Kłosowska, Anna, additional, Lawson-Yuen, Amy, additional, Linder-Lucht, Michaela, additional, Lyons, Greta, additional, Monti Lora, Felipe, additional, Moran, Carla, additional, Müller, Katalin E, additional, Paone, Laura, additional, Paul, Praveen G, additional, Polak, Michel, additional, Porta, Francesco, additional, Reinauer, Christina, additional, de Rijke, Yolanda B, additional, Seckold, Rowen, additional, Menevşe, Tuba Seven, additional, Simm, Peter, additional, Simon, Anna, additional, Spada, Marco, additional, Stoupa, Athanasia, additional, Szeifert, Lilla, additional, Tonduti, Davide, additional, van Toor, Hans, additional, Turan, Serap, additional, Vanderniet, Joel, additional, de Waart, Monique, additional, van der Wal, Ronald, additional, van der Walt, Adri, additional, van Wermeskerken, Anne-Marie, additional, Wierzba, Jolanta, additional, Zibordi, Federica, additional, Zung, Amnon, additional, Peeters, Robin P, additional, and Visser, W Edward, additional

Published
2021
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6. The relationship between meal carbohydrate quantity and the insulin to carbohydrate ratio required to maintain glycaemia is non‐linear in young people with type 1 diabetes: A randomized crossover trial

Author

Cordon, Natalie M., primary, Smart, Carmel E. M., additional, Smith, Grant J., additional, Davis, Elizabeth A., additional, Jones, Timothy W., additional, Seckold, Rowen, additional, Burckhardt, Marie‐ Anne, additional, and King, Bruce R., additional

Published
2021
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7. The relationship between meal carbohydrate quantity and the insulin to carbohydrate ratio required to maintain glycaemia is non‐linear in young people with type 1 diabetes: A randomized crossover trial.

Author

Cordon, Natalie M., Smart, Carmel E. M., Smith, Grant J., Davis, Elizabeth A., Jones, Timothy W., Seckold, Rowen, Burckhardt, Marie‐ Anne, and King, Bruce R.

Subjects
INSULIN therapy, GLYCOSYLATED hemoglobin, STATISTICS, FAT content of food, GLYCEMIC control, CARBOHYDRATE content of food, TYPE 1 diabetes, INGESTION, INSULIN, TREATMENT effectiveness, RANDOMIZED controlled trials, HYPOGLYCEMIA, DESCRIPTIVE statistics, CROSSOVER trials, BREAKFASTS, STATISTICAL models, DATA analysis, DIETARY proteins
Abstract

Objective: To determine if the relationship between meal carbohydrate quantity and the insulin to carbohydrate ratio (ICR) required to maintain glycaemia is linear in people with type 1 diabetes. Methods: We used an open labelled randomized four‐arm cross‐over study design. Participants (N = 31) aged 12–27 years, HbA1c ≤ 64 mmol/mol (8.0%) received insulin doses based on the individual's ICR and the study breakfast carbohydrate quantity and then consumed four breakfasts containing 20, 50, 100 and 150 g of carbohydrate over four consecutive days in randomized order. The breakfast fat and protein percentages were standardized. Postprandial glycaemia was assessed by 5 h continuous glucose monitoring. The primary outcome was percent time in range (TIR) and secondary outcomes included hypoglycaemia, glucose excursion and incremental area under the curve. Statistical analysis included linear mixed modelling and Wilcoxon signed rank tests. Results: The 20 g carbohydrate breakfast had the largest proportion of TIR (0.74 ± 0.29 p < 0.04). Hypoglycaemia was more frequent in the 50 g (n = 13, 42%) and 100 g (n = 15, 50%) breakfasts compared to the 20 g (n = 6, 20%) and 150 g (n = 7, 26%) breakfasts (p < 0.029). The 150 g breakfast glucose excursion pattern was different from the smaller breakfasts with the lowest glucose excursion 0–2 h and the highest excursion from 3.5 to 5 h. Conclusions: A non‐linear relationship between insulin requirement and breakfast carbohydrate content was observed, suggesting that strengthened ICRs are needed for meals with ≤20 and ≥150 g of carbohydrate. Meals with ≥150 g of carbohydrate may benefit from dual wave bolusing. [ABSTRACT FROM AUTHOR]

Published
2022
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8. A Randomized Crossover Trial Comparing Glucose Control During Moderate-Intensity, High-Intensity, and Resistance Exercise With Hybrid Closed-Loop Insulin Delivery While Profiling Potential Additional Signals in Adults With Type 1 Diabetes.

Author

Paldus, Barbora, Morrison, Dale, Zaharieva, Dessi P., Lee, Melissa H., Jones, Hannah, Obeyesekere, Varuni, Lu, Jean, Vogrin, Sara, La Gerche, André, McAuley, Sybil A., MacIsaac, Richard J., Jenkins, Alicia J., Ward, Glenn M., Colman, Peter, Smart, Carmel E. M., Seckold, Rowen, King, Bruce R., Riddell, Michael C., and O’Neal, David N.

Subjects
TYPE 1 diabetes, RESISTANCE training, CROSSOVER trials, GLUCOSE, INSULIN
Abstract

Objective: To compare glucose control with hybrid closed-loop (HCL) when challenged by high intensity exercise (HIE), moderate intensity exercise (MIE), and resistance exercise (RE) while profiling counterregulatory hormones, lactate, ketones, and kinetic data in adults with type 1 diabetes.Research Design and Methods: This study was an open-label multisite randomized crossover trial. Adults with type 1 diabetes undertook 40 min of HIE, MIE, and RE in random order while using HCL (Medtronic MiniMed 670G) with a temporary target set 2 h prior to and during exercise and 15 g carbohydrates if pre-exercise glucose was <126 mg/dL to prevent hypoglycemia. Primary outcome was median (interquartile range) continuous glucose monitoring time-in-range (TIR; 70-180 mg/dL) for 14 h post-exercise commencement. Accelerometer data and venous glucose, ketones, lactate, and counterregulatory hormones were measured for 280 min post-exercise commencement.Results: Median TIR was 81% (67, 93%), 91% (80, 94%), and 80% (73, 89%) for 0-14 h post-exercise commencement for HIE, MIE, and RE, respectively (n = 30), with no difference between exercise types (MIE vs. HIE; P = 0.11, MIE vs. RE, P = 0.11; and HIE vs. RE, P = 0.90). Time-below-range was 0% for all exercise bouts. For HIE and RE compared with MIE, there were greater increases, respectively, in noradrenaline (P = 0.01 and P = 0.004), cortisol (P < 0.001 and P = 0.001), lactate (P ≤ 0.001 and P ≤ 0.001), and heart rate (P = 0.007 and P = 0.015). During HIE compared with MIE, there were greater increases in growth hormone (P = 0.024).Conclusions: Under controlled conditions, HCL provided satisfactory glucose control with no difference between exercise type. Lactate, counterregulatory hormones, and kinetic data differentiate type and intensity of exercise, and their measurement may help inform insulin needs during exercise. However, their potential utility as modulators of insulin dosing will be limited by the pharmacokinetics of subcutaneous insulin delivery. [ABSTRACT FROM AUTHOR]

Published
2022
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9. Long-Term Efficacy of T3 Analogue Triac in Children and Adults With MCT8 Deficiency: A Real-Life Retrospective Cohort Study

Author

van Geest, Ferdy S, Groeneweg, Stefan, van den Akker, Erica L T, Bacos, Iuliu, Barca, Diana, van den Berg, Sjoerd A A, Bertini, Enrico, Brunner, Doris, Brunetti-Pierri, Nicola, Cappa, Marco, Cappuccio, Gerarda, Chatterjee, Krishna, Chesover, Alexander D, Christian, Peter, Coutant, Régis, Craiu, Dana, Crock, Patricia, Dewey, Cheyenne, Dica, Alice, Dimitri, Paul, Dubey, Rachana, Enderli, Anina, Fairchild, Jan, Gallichan, Jonathan, Garibaldi, Luigi R, George, Belinda, Hackenberg, Annette, Heinrich, Bianka, Huynh, Tony, Kłosowska, Anna, Lawson-Yuen, Amy, Linder-Lucht, Michaela, Lyons, Greta, Monti Lora, Felipe, Moran, Carla, Müller, Katalin E, Paone, Laura, Paul, Praveen G, Polak, Michel, Porta, Francesco, Reinauer, Christina, de Rijke, Yolanda B, Seckold, Rowen, Menevşe, Tuba Seven, Simm, Peter, Simon, Anna, Spada, Marco, Stoupa, Athanasia, Szeifert, Lilla, Tonduti, Davide, van Toor, Hans, Turan, Serap, Vanderniet, Joel, de Waart, Monique, van der Wal, Ronald, van der Walt, Adri, van Wermeskerken, Anne-Marie, Wierzba, Jolanta, Zibordi, Federica, Zung, Amnon, Peeters, Robin P, and Visser, W Edward

Published
2022
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12. Long-Term Efficacy of T3 Analogue Triac in Children and Adults With MCT8 Deficiency: A Real-Life Retrospective Cohort Study

Author

Monique de Waart, Anina Enderli, Ferdy S van Geest, Adri van der Walt, Krishna Chatterjee, Sjoerd A A van den Berg, Laura Paone, Patricia Crock, Anne-Marie van Wermeskerken, Lilla Szeifert, Francesco Porta, D Barca, Carla Moran, Katalin E Müller, Alice Dica, Athanasia Stoupa, Felipe Monti Lora, Dana Craiu, Hans van Toor, Peter Christian, Amnon Zung, Stefan Groeneweg, W. Edward Visser, Ronald van der Wal, Régis Coutant, Luigi Garibaldi, Marco Spada, Joel Vanderniet, Jolanta Wierzba, Tony Huynh, Greta Lyons, Annette Hackenberg, Gerarda Cappuccio, Serap Turan, Michaela Linder-Lucht, Jan Fairchild, Peter J Simm, Yolanda B. de Rijke, Enrico Bertini, Amy Lawson-Yuen, Erica L T van den Akker, Bianka Heinrich, Nicola Brunetti-Pierri, Michel Polak, Cheyenne Dewey, Rachana Dubey, Christina Reinauer, Praveen G. Paul, Belinda George, Doris Brunner, Robin P. Peeters, Paul Dimitri, Marco Cappa, Anna Simon, Federica Zibordi, Tuba Seven Menevse, Jonathan Gallichan, Anna Kłosowska, Rowen Seckold, Iuliu Bacos, Davide Tonduti, Alexander D Chesover, Internal Medicine, Pediatrics, Clinical Chemistry, van Geest, Ferdy S, Groeneweg, Stefan, van den Akker, Erica L T, Bacos, Iuliu, Barca, Diana, van den Berg, Sjoerd A A, Bertini, Enrico, Brunner, Dori, Brunetti-Pierri, Nicola, Cappa, Marco, Cappuccio, Gerarda, Chatterjee, Krishna, Chesover, Alexander D, Christian, Peter, Coutant, Régi, Craiu, Dana, Crock, Patricia, Dewey, Cheyenne, Dica, Alice, Dimitri, Paul, Dubey, Rachana, Enderli, Anina, Fairchild, Jan, Gallichan, Jonathan, Garibaldi, Luigi R, George, Belinda, Hackenberg, Annette, Heinrich, Bianka, Huynh, Tony, Kłosowska, Anna, Lawson-Yuen, Amy, Linder-Lucht, Michaela, Lyons, Greta, Lora, Felipe Monti, Moran, Carla, Müller, Katalin E, Paone, Laura, Paul, Praveen G, Polak, Michel, Porta, Francesco, Reinauer, Christina, de Rijke, Yolanda B, Seckold, Rowen, Menevşe, Tuba Seven, Simm, Peter, Simon, Anna, Spada, Marco, Stoupa, Athanasia, Szeifert, Lilla, Tonduti, Davide, van Toor, Han, Turan, Serap, Vanderniet, Joel, de Waart, Monique, van der Wal, Ronald, van der Walt, Adri, van Wermeskerken, Anne-Marie, Wierzba, Jolanta, Zibordi, Federica, Zung, Amnon, Peeters, Robin P, and Visser, W Edward

Subjects
Male, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Biochemistry, chemistry.chemical_compound, Endocrinology, Clinical endpoint, MCT8 Deficiency, Child, Symporters, Thyroid, Middle Aged, Muscular Atrophy, Treatment Outcome, medicine.anatomical_structure, Child, Preschool, Muscle Hypotonia, Triiodothyronine, Female, Adult, Monocarboxylic Acid Transporters, medicine.medical_specialty, Adolescent, Context (language use), AHDS, Young Adult, SDG 3 - Good Health and Well-being, Internal medicine, Heart rate, medicine, Humans, Allan-Herndon-Dudley syndrome, Aged, Retrospective Studies, Creatinine, Allan–Herndon–Dudley syndrome, T3 analogue, business.industry, Biochemistry (medical), Infant, Retrospective cohort study, medicine.disease, chemistry, Mutation, Mental Retardation, X-Linked, business, thyromimetic drug, Follow-Up Studies, Hormone
Abstract

Context Patients with mutations in thyroid hormone transporter MCT8 have developmental delay and chronic thyrotoxicosis associated with being underweight and having cardiovascular dysfunction. Objective Our previous trial showed improvement of key clinical and biochemical features during 1-year treatment with the T3 analogue Triac, but long-term follow-up data are needed. Methods In this real-life retrospective cohort study, we investigated the efficacy of Triac in MCT8-deficient patients in 33 sites. The primary endpoint was change in serum T3 concentrations from baseline to last available measurement. Secondary endpoints were changes in other thyroid parameters, anthropometric parameters, heart rate, and biochemical markers of thyroid hormone action. Results From October 15, 2014 to January 1, 2021, 67 patients (median baseline age 4.6 years; range, 0.5-66) were treated up to 6 years (median 2.2 years; range, 0.2-6.2). Mean T3 concentrations decreased from 4.58 (SD 1.11) to 1.66 (0.69) nmol/L (mean decrease 2.92 nmol/L; 95% CI, 2.61-3.23; P < 0.0001; target 1.4-2.5 nmol/L). Body-weight-for-age exceeded that of untreated historical controls (mean difference 0.72 SD; 95% CI, 0.36-1.09; P = 0.0002). Heart-rate-for-age decreased (mean difference 0.64 SD; 95% CI, 0.29-0.98; P = 0.0005). SHBG concentrations decreased from 245 (99) to 209 (92) nmol/L (mean decrease 36 nmol/L; 95% CI, 16-57; P = 0.0008). Mean creatinine concentrations increased from 32 (11) to 39 (13) µmol/L (mean increase 7 µmol/L; 95% CI, 6-9; P < 0.0001). Mean creatine kinase concentrations did not significantly change. No drug-related severe adverse events were reported. Conclusions Key features were sustainably alleviated in patients with MCT8 deficiency across all ages, highlighting the real-life potential of Triac for MCT8 deficiency.

Published
2021

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