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1. Remote haemodynamic-guided heart failure management in France: Results from the CardioMEMS HF System Post-Market Study (COAST) French cohort

Author

de Groote, Pascal, Thuny, Franck, Blanchart, Katrien, Gueffet, Jean-Pierre, Habib, Gilbert, Salvat, Muriel, Leclercq, Christophe, Mouquet, Frederic, Roncalli, Jérôme, Sebbag, Laurent, Cassagneau, Romain, Peyrol, Michael, Sabatier, Remi, Gazzola, Carlo, Henderson, John, Adamson, Philip B., and Roubille, François

Published
2024
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2. Right Ventriculoarterial Coupling Surrogates and Long-Term Survival in LVAD Recipients: Results of the ASSIST-ICD Multicentric Registry

Author

BENEYTO, MAXIME, MARTINS, RAPHAËL, GALAND, VINCENT, KINDO, MICHEL, SCHNEIDER, CLÉMENT, SEBESTYEN, ALEXANDRE, BOIGNARD, AUDE, SEBBAG, LAURENT, POZZI, MATTEO, GENET, THIBAUD, BOURGUIGNON, THIERRY, MARTIN, ANNE-CÉLINE, ACHOUH, PAUL, VANHUYSE, FABRICE, BLANG, HUGUES, DAVID, CHARLES HENRI, MICHEL, MAGALI, ANSELME, FRÉDÉRIC, LITZLER, PIERRE-YVES, JUNGLING, MARIE, VINCENTELLI, ANDRÉ, ESCHALIER, ROMAIN, D'OSTREVY, NICOLAS, NATAF, PATRICK, PARA, MARYLOU, GARNIER, FABIEN, RAJINTHAN, PRIYANKA, PORTERIE, JEAN, FAURE, MAXIME, PICARD, FRANÇOIS, GAUDARD, PHILIPPE, ROUVIÈRE, PHILIPPE, BABATASI, GÉRARD, BLANCHART, KATRIEN, GARIBOLDI, VLAD, PORTO, ALIZÉE, FLECHER, ERWAN, and DELMAS, CLEMENT

Published
2024
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8. IMPact of the COVID-19 epidemic on the moRTAlity of kidney transplant recipients and candidates in a French Nationwide registry sTudy (IMPORTANT)

Author

Thaunat, Olivier, Morelon, Emmanuel, Levi, Charlene, Buron, Fanny, Koenig, Alice, Barba, Thomas, Caillard, Sophie, Moulin, Bruno, Fafi-Kremer, Samira, Hazzan, Marc, Dany, Anglicheau, Hertig, Alexandre, Tourret, Jérôme, Barrou, Benoit, Couzi, Lionel, Merville, Pierre, Kaminski, Anna, Moal, Valérie, Legris, Tristan, Westeel, Pierre-François, Jaureguy, Maïté, Frimat, Luc, Ducloux, Didier, Bamoulid, Jamal, Bertrand, Dominique, Tsimaratos, Michel, Garaix-Gilardo, Florentine, Dumortier, Jérôme, Mussot, Sacha, Roux, Antoine, Sebbag, Laurent, Le Meur, Yannick, Blancho, Gilles, Masset, Christophe, Kamar, Nassim, Francois, Hélène, Rondeau, Eric, Bouvier, Nicolas, Mousson, Christiane, Buchler, Matthias, Gatault, Philippe, Augusto, Jean-François, Duveau, Agnès, Vigneau, Cécile, Morin, Marie-Christine, Chemouny, Jonathan, Golbin, Leonard, Grimbert, Philippe, Matignon, Marie, Durrbach, Antoine, Greze, Clarisse, Snanoudj, Renaud, Colosio, Charlotte, Schvartz, Betoul, Malvezzi, Paolo, Mariat, Christophe, Thierry, Antoine, Le Quintrec, Moglie, Sicard, Antoine, Rerolle, Jean Philippe, Heng, Anne-Élisabeth, Garrouste, Cyril, Coponat, Henri Vacher, Epailly, Éric, Brugiere, Olivier, Dharancy, Sébastien, Salame, Éphrem, Saliba, Faouzi, Legeai, Camille, Anglicheau, Dany, Pastural, Myriam, Savoye, Emilie, Bayer, Florian, Le Meur, Yann, and Bastien, Olivier

Published
2020
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9. An initial report from the French SOT COVID Registry suggests high mortality due to COVID-19 in recipients of kidney transplants

Author

Caillard, Sophie, Moulin, Bruno, Fafi-Kremer, Samira, Hazzan, Marc, Anglicheau, Dany, Hertig, Alexandre, Tourret, Jérôme, Barrou, Benoit, Morelon, Emmanuel, Thaunat, Olivier, Couzi, Lionel, Merville, Pierre, Moal, Valérie, Legris, Tristan, Westeel, Pierre-François, Jaureguy, Maïté, Frimat, Luc, Ducloux, Didier, Bamoulid, Jamal, Bertrand, Dominique, Tsimaratos, Michel, Garaix-Gilardo, Florentine, Dumortier, Jérôme, Mussot, Sacha, Roux, Antoine, Sebbag, Laurent, Le Meur, Yannick, Blancho, Gilles, Masset, Christophe, Kamar, Nassim, Francois, Hélène, Rondeau, Eric, Bouvier, Nicolas, Mousson, Christiane, Buchler, Matthias, Gatault, Philippe, Augusto, Jean-François, Duveau, Agnès, Vigneau, Cécile, Morin, Marie-Christine, Chemouny, Jonathan, Golbin, Leonard, Grimbert, Philippe, Matignon, Marie, Durrbach, Antoine, Greze, Clarisse, Snanoudj, Renaud, Colosio, Charlotte, Schvartz, Betoul, Malvezzi, Paolo, Mariat, Christophe, Thierry, Antoine, Le Quintrec, Moglie, Sicard, Antoine, Rerolle, Jean Philippe, Heng, Anne-Élisabeth, Garrouste, Cyril, Coponat, Henri Vacher, Epailly, Éric, Brugiere, Olivier, Dharancy, Sébastien, Salame, Éphrem, Saliba, Faouzi, Moal, Valerie, Westeel, Pierre Francois, Chemouny, Jonathan M., Duveau, Agnes, and Chavarot, Nathalie

Published
2020
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10. Practical management of worsening renal function in outpatients with heart failure and reduced ejection fraction: Statement from a panel of multidisciplinary experts and the Heart Failure Working Group of the French Society of Cardiology

Author

Mewton, Nathan, Girerd, Nicolas, Boffa, Jean-Jacques, Courivaud, Cécile, Isnard, Richard, Juillard, Laurent, Lamblin, Nicolas, Legrand, Matthieu, Logeart, Damien, Mariat, Christophe, Meune, Edith, Sabouret, Pierre, Sebbag, Laurent, and Rossignol, Patrick

Published
2020
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11. Abstract 11939: Phosphorylation of Serca2 at Serine 663, a Physiological and Clinical Event in Ischemic Heart Diseases, That Regulates Intracellular Ca2+ and Cell Death

Author

GONNOT, FABRICE, Dia, Maya, GOURIOU, Yves, Bidaux, Gabriel, Chouabe, Christophe, Crola Da Silva, Claire, Ducreux, Sylvie, PILLOT, Bruno, Kaczmarczyk, Andrea, Leon, Christelle, Perret, Coralie, Sciandra, Franck, Farhat, Fadi, Sebbag, laurent, Bochaton, Thomas, Thibault, Helene, Ovize, Michel, Paillard, Melanie, and Gomez, Ludovic

Published
2022
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15. Heart transplant centers with multidisciplinary team show a higher level of chronic illness management – Findings from the International BRIGHT Study

Author

Crespo-Leiro, Maria G., Cupples, Sandra, De Simone, Paolo, Groenewoud, Albert, Kugler, Christiane, Ohler, Linda, Van Cleemput, Johan, Poncelet, Alain Jean, Sebbag, Laurent, Michel, Magali, Bernard, Andrée, Doesch, Andreas, Livi, Ugolino, Manfredini, Valentina, Brossa-Loidi, Vicens, Segovia-Cubero, Javier, Almenar-Bonet, Luis, Segura Saint-Gerons, Carmen, Mohacsi, Paul, Horvath, Eva, Riotto, Cheryl, Parry, Gareth, Firouzi, Ashi, Kozuszko, Stella, Haddad, Haissam, Kaan, Annemarie, Fisher, Grant, Miller, Tara, Flattery, Maureen, Ludrosky, Kristin, Coleman, Bernice, Trammell, Jacqueline, St. Clair, Katherine, Kao, Andrew, Molina, Maria, Canales, Karyn Ryan, de Almeida, Samira Scalso, Ayoub, Andrea Cotait, Barone, Fernanda, Harkess, Michelle, Maddicks-Law, Joanne, Cajita, Maan Isabella, Baumgartner, Eva, Berben, Lut, Denhaerynck, Kris, Helmy, Remon, Schönfeld, Sandra, Berger, Gabriele, Vetter, Christine, Dobbels, Fabienne, Russell, Cynthia L., and De Geest, Sabina

Published
2017
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16. Health literacy in heart transplantation: Prevalence, correlates and associations with health behaviors—Findings from the international BRIGHT study

Author

Cajita, Maan Isabella, Denhaerynck, Kris, Dobbels, Fabienne, Berben, Lut, Russell, Cynthia L., Davidson, Patricia M., De Geest, Sabina, Crespo-Leiro, Maria G., Cupples, Sandra, De Simone, Paolo, Groenewoud, Albert, Kugler, Christiane, Ohler, Linda, Vanhaecke, Johan, Jean Poncelet, Alain, Sebbag, Laurent, Michel, Magalu, Bernard, Andrée, Doesch, Andreas, Livi, Ugolino, Manfredini, Valentina, Brossa Loidi, Vicens, Segovia, Javier, Amenar, Luis, Segura Saint-Gerons, Carmen, Mohacsi, Paul, Horvath, Eva, Riotto, Cheryl, Parry, Gareth, Firouzi, Ashi, Kozuszko, Stella, Haddad, Haissam, Kaan, Annemarie, Fisher, Grant, Miller, Tara, Flattery, Maureen, Ludrosky, Kristin, Coleman, Bernice, Trammell, Jacqueline, St. Clair, Katherine, Kao, Andrew, Molina, Maria, Ryan Canalesa, Karyn, de Almeida, Samira Scalso, Ayoub, A. Cotait, Barone, Fernanda, Harkess, Michelle, and Maddicks-Law, Joanne

Published
2017
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17. Diuretic dose is a strong prognostic factor in ambulatory patients awaiting heart transplantation

Author

Baudry, Guillaume, primary, Coutance, Guillaume, additional, Dorent, Richard, additional, Bauer, Fabrice, additional, Blanchart, Katrien, additional, Boignard, Aude, additional, Chabanne, Céline, additional, Delmas, Clément, additional, D'Ostrevy, Nicolas, additional, Epailly, Eric, additional, Gariboldi, Vlad, additional, Gaudard, Philippe, additional, Goéminne, Céline, additional, Grosjean, Sandrine, additional, Guihaire, Julien, additional, Guillemain, Romain, additional, Mattei, Mathieu, additional, Nubret, Karine, additional, Pattier, Sabine, additional, Vermes, Emmanuelle, additional, Sebbag, Laurent, additional, Duarte, Kevin, additional, and Girerd, Nicolas, additional

Published
2023
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18. Sequencing and titrating approach of therapy in heart failure with reduced ejection fraction following the 2021 European Society of Cardiology guidelines: an international cardiology survey

Author

Fauvel, Charles, Bonnet, Guillaume, Mullens, Wilfried, Giraldo, Clara Ines Saldarriaga, Meznar, Anja Zupan, Barasa, Anders, Tokmakova, Mariya, Shchendrygina, Anastasia, Costa, Francisco Moscoso, Mapelli, Massimo, Zemrak, Filip, Tops, Laurens F., Jakus, Nina, Sultan, Arian, Bahouth, Fadel, Hadjseyd, Chahr-Eddine, Salvat, Muriel, Anselmino, Matteo, Messroghli, Daniel, Weberndorfer, Vanessa, Giverts, Ilya, Bochaton, Thomas, Berthelot, Emmanuelle, Legallois, Damien, Beauvais, Florence, Bauer, Fabrice, Lamblin, Nicolas, Damy, Thibaud, Girerd, Nicolas, Sebbag, Laurent, Pezel, Theo, Cohen-Solal, Alain, Rosano, Giuseppe, Roubille, Francois, Mewton, Nathan, Fauvel, Charles, Bonnet, Guillaume, Mullens, Wilfried, Giraldo, Clara Ines Saldarriaga, Meznar, Anja Zupan, Barasa, Anders, Tokmakova, Mariya, Shchendrygina, Anastasia, Costa, Francisco Moscoso, Mapelli, Massimo, Zemrak, Filip, Tops, Laurens F., Jakus, Nina, Sultan, Arian, Bahouth, Fadel, Hadjseyd, Chahr-Eddine, Salvat, Muriel, Anselmino, Matteo, Messroghli, Daniel, Weberndorfer, Vanessa, Giverts, Ilya, Bochaton, Thomas, Berthelot, Emmanuelle, Legallois, Damien, Beauvais, Florence, Bauer, Fabrice, Lamblin, Nicolas, Damy, Thibaud, Girerd, Nicolas, Sebbag, Laurent, Pezel, Theo, Cohen-Solal, Alain, Rosano, Giuseppe, Roubille, Francois, and Mewton, Nathan

Abstract

Aims In symptomatic patients with heart failure and reduced ejection fraction (HFrEF), recent international guidelines recommend initiating four major therapeutic classes rather than sequential initiation. It remains unclear how this change in guidelines is perceived by practicing cardiologists versus heart failure (HF) specialists. Methods and results An independent academic web-based survey was designed by a group of HF specialists and posted by email and through various social networks to a broad community of cardiologists worldwide 1 year after the publication of the latest European HF guidelines. Overall, 615 cardiologists (38 [32-47] years old, 63% male) completed the survey, of which 58% were working in a university hospital and 26% were HF specialists. The threshold to define HFrEF was <= 40% for 61% of the physicians. Preferred drug prescription for the sequential approach was angiotensin-converting enzyme inhibitors or angiotensin receptor-neprilysin inhibitors first (74%), beta-blockers second (55%), mineralocorticoid receptor antagonists third (52%), and sodium-glucose cotransporter 2 inhibitors (53%) fourth. Eighty-four percent of participants felt that starting all four classes was feasible within the initial hospitalization, and 58% felt that titration is less important than introducing a new class. Age, status in training, and specialization in HF field were the principal characteristics that significantly impacted the answers. Conclusion In a broad international cardiology community, the 'historical approach' to HFrEF therapies remains the preferred sequencing approach. However, accelerated introduction and uptitration are also major treatment goals. Strategy trials in treatment guidance are needed to further change practices. [GRAPHICS] .

Published
2023

20. Serine 663-dependent phosphorylation of SERCA2 in ischemic heart disease: Regulation of calcium homeostasis, cell death and myocardial infarct size

Author

Gonnot, Fabrice, primary, Dia, Maya, additional, Gouriou, Yves, additional, Bidaux, Gabriel, additional, Chouabe, Christophe, additional, da Silva, Claire Crola, additional, Ducreux, Sylvie, additional, Pillot, Bruno, additional, Leon, Christelle, additional, Perret, Coralie, additional, Sciandra, Franck, additional, Faraht, Fadi, additional, Sebbag, Laurent, additional, Bochaton, Thomas, additional, Thibault, Helene, additional, Ovize, Michel, additional, Paillard, Melanie, additional, and Gomez, Ludovic, additional

Published
2022
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22. Sequencing and Titrating Approach of Therapy in Heart Failure with Reduced Ejection Fraction Following the 2021 ESC guidelines: an International Cardiology Survey

Author

Fauvel, Charles, Bonnet, Guillaume, Mullens, Wilfried, Giraldo, Clara Ines Saldarriaga, Mežnar, Anja Zupan, Barasa, Anders, Tokmakova, Mariya, Shchendrygina, Anastasia, Costa, Francisco Moscoso, Mapelli, Massimo, Zemrak, Filip, Tops, Laurens, Jakus, Nina, Sultan, Arian, Bahouth, Fadel, Hadjseyd, Chahr‐eddine, Salvat, Muriel, Anselmino, Matteo, Messroghli, Daniel, Weberndörfer, Vanessa, Giverts, Ilya, Bochaton, Thomas, Berthelot, Emmanuelle, Legallois, Damien, Beauvais, Florence, Bauer, Fabrice, Lamblin, Nicolas, Damy, Thibaud, Girerd, Nicolas, Sebbag, Laurent, Pezel, Théo, Cohen-Solal, Alain, Rosano, Giuseppe, Roubille, François, Mewton, Nathan, CHU Rouen, Normandie Université (NU), Ohio State University [Columbus] (OSU), Hôpital Haut-Lévêque [CHU Bordeaux], CHU Bordeaux [Bordeaux], Ziekenhuis Oost-Limburg (ZOL), Hasselt University (UHasselt), Universidad Pontificia Bolivariana (UPB), University Medical Centre Ljubljana [Ljubljana, Slovenia] (UMCL), Glostrup Hospital, Medical University of Plovdiv, Sechenov First Moscow State Medical University, Hospital de Santa Cruz, Centro Cardiologico Monzino [Milano], Dpt di Scienze Cliniche e di Comunità [Milano] (DISCCO), Università degli Studi di Milano = University of Milan (UNIMI)-Università degli Studi di Milano = University of Milan (UNIMI)-Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), Università degli Studi di Milano = University of Milan (UNIMI), St Bartholomew's Hospital (London), Leiden University Medical Center (LUMC), Universiteit Leiden, University Hospital Centre Zagreb, Partenaires INRAE, Universitätsklinikum Köln (Uniklinik Köln), Bnai Zion Hospital, Centre d'Investigation Clinique [Bron] (CIC1407), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Groupement Hospitalier Est [Bron], Hôpital Louis Pradel [CHU - HCL], Hospices Civils de Lyon (HCL), CHU Grenoble, Università degli studi di Torino = University of Turin (UNITO), German Heart Institute Berlin [Berlin, Germany] (GHIB), Cardiovascular Research Institute Maastricht (CARIM), Maastricht University [Maastricht], Maastricht University Medical Centre (MUMC), Massachusetts General Hospital [Boston], AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Service de cardiologie et de pathologie vasculaire [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Marqueurs cardiovasculaires en situation de stress (MASCOT (UMR_S_942 / U942)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Hôpital Charles Nicolle [Rouen], Normandie Université (NU)-Normandie Université (NU), CHU Lille, Université de Lille, Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP), CHU Henri Mondor [Créteil], Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS San Raffaele Pisana), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), and Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)

Subjects
Pharmacology, Treatment, [SDV]Life Sciences [q-bio], Heart failure, Guideline
Abstract

International audience; Aims: In symptomatic patients with heart failure and reduced ejection fraction (HFrEF), recent international guidelines recommend initiating four major therapeutic classes rather than sequential initiation. It remains unclear how this change in guidelines is perceived by practicing cardiologists versus heart failure (HF) specialists.Methods and results: An independent academic web-based survey was designed by a group of HF specialists and posted by email and through various social networks to a broad community of cardiologists worldwide 1 year after the publication of the latest European HF guidelines. Overall, 615 cardiologists (38 [32-47] years old, 63% male) completed the survey, of which 58% were working in a university hospital and 26% were HF specialists. The threshold to define HFrEF was ≤40% for 61% of the physicians. Preferred drug prescription for the sequential approach was angiotensin-converting enzyme inhibitors or angiotensin receptor-neprilysin inhibitors first (74%), beta-blockers second (55%), mineralocorticoid receptor antagonists third (52%), and sodium-glucose cotransporter 2 inhibitors (53%) fourth. Eighty-four percent of participants felt that starting all four classes was feasible within the initial hospitalization, and 58% felt that titration is less important than introducing a new class. Age, status in training, and specialization in HF field were the principal characteristics that significantly impacted the answers.Conclusion: In a broad international cardiology community, the 'historical approach' to HFrEF therapies remains the preferred sequencing approach. However, accelerated introduction and uptitration are also major treatment goals. Strategy trials in treatment guidance are needed to further change practices.

Published
2022
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23. Sequencing and titrating approach of therapy in heart failure with reduced ejection fraction following the 2021 European Society of Cardiology guidelines: an international cardiology survey

Author

Fauvel, Charles, primary, Bonnet, Guillaume, additional, Mullens, Wilfried, additional, Giraldo, Clara Ines Saldarriaga, additional, Mežnar, Anja Zupan, additional, Barasa, Anders, additional, Tokmakova, Mariya, additional, Shchendrygina, Anastasia, additional, Costa, Francisco Moscoso, additional, Mapelli, Massimo, additional, Zemrak, Filip, additional, Tops, Laurens F., additional, Jakus, Nina, additional, Sultan, Arian, additional, Bahouth, Fadel, additional, Hadjseyd, Chahr‐eddine, additional, Salvat, Muriel, additional, Anselmino, Matteo, additional, Messroghli, Daniel, additional, Weberndörfer, Vanessa, additional, Giverts, Ilya, additional, Bochaton, Thomas, additional, Courand, Pierre Yves, additional, Berthelot, Emmanuelle, additional, Legallois, Damien, additional, Beauvais, Florence, additional, Bauer, Fabrice, additional, Lamblin, Nicolas, additional, Damy, Thibaud, additional, Girerd, Nicolas, additional, Sebbag, Laurent, additional, Pezel, Théo, additional, Cohen‐Solal, Alain, additional, Rosano, Giuseppe, additional, Roubille, François, additional, and Mewton, Nathan, additional

Published
2022
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25. Heart transplant centers with multidisciplinary team show a higher level of chronic illness management – Findings from the International BRIGHT Study

Author

Cajita, Maan Isabella, Baumgartner, Eva, Berben, Lut, Denhaerynck, Kris, Helmy, Remon, Schönfeld, Sandra, Berger, Gabriele, Vetter, Christine, Dobbels, Fabienne, Russell, Cynthia L., De Geest, Sabina, Crespo-Leiro, Maria G., Cupples, Sandra, De Simone, Paolo, Groenewoud, Albert, Kugler, Christiane, Ohler, Linda, Van Cleemput, Johan, Poncelet, Alain Jean, Sebbag, Laurent, Michel, Magali, Bernard, Andrée, Doesch, Andreas, Livi, Ugolino, Manfredini, Valentina, Brossa-Loidi, Vicens, Segovia-Cubero, Javier, Almenar-Bonet, Luis, Saint-Gerons, Carmen Segura, Mohacsi, Paul, Horvath, Eva, Riotto, Cheryl, Parry, Gareth, Firouzi, Ashi, Kozuszko, Stella, Haddad, Haissam, Kaan, Annemarie, Fisher, Grant, Miller, Tara, Flattery, Maureen, Ludrosky, Kristin, Coleman, Bernice, Trammell, Jacqueline, St. Clair, Katherine, Kao, Andrew, Molina, Maria, Canales, Karyn Ryan, de Almeida, Samira Scalso, Ayoub, Andrea Cotait, Barone, Fernanda, Harkess, Michelle, and Maddicks-Law, Joanne

Published
2017
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26. SERCA2 phosphorylation at serine 663 is a key regulator of Ca2+ homeostasis in heart diseases.

Author

Gonnot, Fabrice, Boulogne, Laura, Brun, Camille, Dia, Maya, Gouriou, Yves, Bidaux, Gabriel, Chouabe, Christophe, Crola Da Silva, Claire, Ducreux, Sylvie, Pillot, Bruno, Kaczmarczyk, Andrea, Leon, Christelle, Chanon, Stephanie, Perret, Coralie, Sciandra, Franck, Dargar, Tanushri, Gache, Vincent, Farhat, Fadi, Sebbag, Laurent, and Bochaton, Thomas

Subjects
HOMEOSTASIS, HEART diseases, SERINE, RYANODINE receptors, MYOCARDIAL infarction, PHOSPHORYLATION, REPERFUSION injury
Abstract

Despite advances in cardioprotection, new therapeutic strategies capable of preventing ischemia-reperfusion injury of patients are still needed. Here, we discover that sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA2) phosphorylation at serine 663 is a clinical and pathophysiological event of cardiac function. Indeed, the phosphorylation level of SERCA2 at serine 663 is increased in ischemic hearts of patients and mouse. Analyses on different human cell lines indicate that preventing serine 663 phosphorylation significantly increases SERCA2 activity and protects against cell death, by counteracting cytosolic and mitochondrial Ca2+ overload. By identifying the phosphorylation level of SERCA2 at serine 663 as an essential regulator of SERCA2 activity, Ca2+ homeostasis and infarct size, these data contribute to a more comprehensive understanding of the excitation/contraction coupling of cardiomyocytes and establish the pathophysiological role and the therapeutic potential of SERCA2 modulation in acute myocardial infarction, based on the hotspot phosphorylation level of SERCA2 at serine 663 residue. Despite advances in cardioprotection, new therapeutic strategies precluding ischemia-reperfusion injury of patients are still needed. Here, the authors show that preventing serine 663 phosphorylation of SERCA2, significantly increases its activity and protects against cell death, by counteracting cytosolic and mitochondrial Ca2+ overload. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Practical management of frailty in older patients with heart failure

Author

Boureau, Anne‐Sophie, primary, Annweiler, Cédric, additional, Belmin, Joël, additional, Bouleti, Claire, additional, Chacornac, Mathieu, additional, Chuzeville, Michel, additional, David, Jean‐Philippe, additional, Jourdain, Patrick, additional, Krolak‐Salmon, Pierre, additional, Lamblin, Nicolas, additional, Paccalin, Marc, additional, Sebbag, Laurent, additional, and Hanon, Olivier, additional

Published
2022
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28. Prognosis value of Forrester's classification in advanced heart failure patients awaiting heart transplantation

Author

Baudry, Guillaume, primary, Coutance, Guillaume, additional, Dorent, Richard, additional, Bauer, Fabrice, additional, Blanchart, Katrien, additional, Boignard, Aude, additional, Chabanne, Céline, additional, Delmas, Clément, additional, D'Ostrevy, Nicolas, additional, Epailly, Eric, additional, Gariboldi, Vlad, additional, Gaudard, Philippe, additional, Goéminne, Céline, additional, Grosjean, Sandrine, additional, Guihaire, Julien, additional, Guillemain, Romain, additional, Mattei, Mathieu, additional, Nubret, Karine, additional, Pattier, Sabine, additional, Pozzi, Matteo, additional, Rossignol, Patrick, additional, Vermes, Emmanuelle, additional, Sebbag, Laurent, additional, and Girerd, Nicolas, additional

Published
2022
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29. De Novo Complement-Binding Anti-HLA Antibodies in Heart Transplanted Patients Is Associated with Severe Cardiac Allograft Vasculopathy and Poor Long-Term Survival

Author

Baudry, Guillaume, primary, Pozzi, Matteo, additional, Aubry, Matthieu, additional, Hugon-Vallet, Elisabeth, additional, Mocan, Raluca, additional, Chalabreysse, Lara, additional, Portran, Philippe, additional, Obadia, Jean-François, additional, Thaunat, Olivier, additional, Girerd, Nicolas, additional, Dubois, Valérie, additional, and Sebbag, Laurent, additional

Published
2022
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35. Clinical Utility of Biochemical Markers for the Prediction of COVID-19−Related Mortality in Kidney Transplant Recipients

Author

Caillard, Sophie, Moulin, Bruno, Fafi-Kremer, Samira, Hazzan, Marc, Anglicheau, Dany, Hertig, Alexandre, Tourret, Jérôme, Barrou, Benoit, Morelon, Emmanuel, Thaunat, Olivier, Couzi, Lionel, Merville, Pierre, Moal, Valérie, Legris, Tristan, Westeel, Pierre-François, Jaureguy, Maïté, Frimat, Luc, Ducloux, Didier, Bamoulid, Jamal, Bertrand, Dominique, Tsimaratos, Michel, Garaix-Gilardo, Florentine, Dumortier, Jérôme, Mussot, Sacha, Roux, Antoine, Sebbag, Laurent, Le Meur, Yannick, Blancho, Gilles, Masset, Christophe, Kamar, Nassim, Francois, Hélène, Rondeau, Eric, Bouvier, Nicolas, Mousson, Christiane, Buchler, Matthias, Gatault, Philippe, Augusto, Jean-François, Duveau, Agnès, Vigneau, Cécile, Morin, Marie-Christine, Chemouny, Jonathan, Golbin, Leonard, Grimbert, Philippe, Matignon, Marie, Durrbach, Antoine, Greze, Clarisse, Snanoudj, Renaud, Colosio, Charlotte, Schvartz, Betoul, Malvezzi, Paolo, Mariat, Christophe, Thierry, Antoine, Le Quintrec, Moglie, Sicard, Antoine, Rerolle, Jean Philippe, Heng, Anne-Élisabeth, Garrouste, Cyril, Coponat, Henri Vacher, Epailly, Éric, Brugiere, Olivier, Dharancy, Sébastien, Salame, Éphrem, Saliba, Faouzi, Chavarot, Nathalie, Westeel, Pierre François, Jdidou, Mariam, Goutadier, Valentin, Chemouny, Jonathan M., and Rerolle, Jean-Philippe

Published
2021
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44. Outcome Predictors and Safety of Home Dobutamine Intravenous Infusion in End Stage Heart Failure Patients

Author

Jobbé-Duval, Antoine, primary, Bochaton, Thomas, additional, Baudry, Guillaume, additional, Bonnefoy-Cudraz, Eric, additional, Hugon-Vallet, Elisabeth, additional, Pozzi, Matteo, additional, Obadia, Jean-Francois, additional, Tomasevic, Danka, additional, Amaz, Camille, additional, Mewton, Nathan, additional, and Sebbag, Laurent, additional

Published
2021
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46. Prevalence of low health literacy levels in decompensated heart failure compared with acute myocardial infarction patients

Author

Perrin, Adèle, primary, Abdalla, Gergis, additional, Viprey, Marie, additional, Delahaye, François, additional, Mewton, Nathan, additional, Ovize, Michel, additional, Sebbag, Laurent, additional, Bochaton, Thomas, additional, Dima, Alexandra L., additional, Bravant, Estelle, additional, Schott, Anne‐Marie, additional, and Haesebaert, Julie, additional

Published
2021
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50. ARNI Pre-Operative Use and Vasoplegic Syndrome in Patients Undergoing Heart Transplantation or Left Ventricular Assist Device Surgery.

Author

Haider, Lamis, Hugon-Vallet, Elisabeth, Constantin, Jean Philippe, Riad, Zakaria, Sebbag, Laurent, and Mewton, Nathan

Subjects
HEART assist devices, HEART transplant recipients, HEART transplantation, HEMORRHAGIC shock, CARDIAC output, SURGERY
Abstract

Background: Vasoplegic syndrome after orthotopic heart transplantation (OHT) or left ventricular assist device (LVAD) implantation is a rare but highly lethal syndrome with complex etiologies. The objective of this study was to assess if the preoperative use of sacubitril-valsartan combination is associated with an increased vasoplegic syndrome (VS) frequency after OHT or LVAD implantation and its relationship with 30-day mortality. Methods: A retrospective review of perioperative data, between January 2016 and December 2017, from 73 consecutive OHT and LVAD surgery adult patients at our institution was performed. VS was defined as normal cardiac output with persistent low systemic resistance requiring a norepinephrine intravenous perfusion > 0.5 µg/kg/min and the absence of sepsis or hemorrhagic shock within 48 h after surgery. Patients were all followed-up for adverse events and all-cause mortality at 30 days. Results: In our cohort of 73 patients (median age 51.7 years, 65% male patients), 25 (34%) patients developed VS. Twenty-two (30.1%) patients were on ARNI at the time of surgery, 31 (42.5%) were on other RAS blockers, 12 (16.4%) were on norepinephrine and 8 (11%) had no pre-operative drug. The pre-operative use of any vasoactive agent, was not significantly associated with VS (OR = 1.36; IC95% [0.78; 2.35]; p = 0.38). The pre-operative use of an ARNI compared to all other groups was not significantly associated with VS (OR = 2.0; IC95% [0.71; 5.62]; p = 0.19). The pre-operative use of an ARNI compared to other RAS blockers was also not significantly associated with VS (OR = 1.25; IC95% [0.37; 4.26]; p = 0.72). At 30 days, 18 (24.7%) patients had died. The pre-operative treatment with ARNI, or other RAS inhibitors was associated with a significantly lower rate of death compared to the absence of treatment (HR = 0.11; IC95% [0.02; 0.55]; p = 0.009 for ARNI and HR = 0.20; IC95% [0.06; 0.69]; p = 0.011 for other RASi). Conclusions: Preoperative use of sacubitril-valsartan was not significantly associated with development of vasoplegic syndrome in patients undergoing OHT or LVAD surgery. Furthermore, our data suggests a significant 30-day survival benefit with efficient renin-angiotensin blockade before surgery. [ABSTRACT FROM AUTHOR]

Published
2022
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