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1. Native-Valve Endocarditis

Author

Abikhzer, Gad, Levett, Jeremy Y., Sebag, Igal A., Pelletier-Galarneau, Matthieu, Pelletier-Galarneau, Matthieu, editor, and Martineau, Patrick, editor

Published
2022
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4. 2023 CCS/CSE Standards for Physician Training and Maintenance of Competence in Adult Echocardiography: Executive Summary

Author

Nair, Parvathy, primary, Chen-Tournoux, Annabel, additional, Almufleh, Aws S., additional, Blissett, Sarah, additional, Ducas, Robin, additional, Fine, Nowell M., additional, Johri, Amer M., additional, Kushneriuk, Dominique, additional, Ramer, Sarah, additional, Sanfilippo, Anthony, additional, Thibodeau-Jarry, Nicolas, additional, Yu, Eric, additional, Bewick, David, additional, Burwash, Ian G., additional, Chow, Chi-Ming, additional, Cooley, Heather, additional, De, Sabe, additional, Douflé, Ghislaine, additional, Fagan, Susan M., additional, Henri, Christine, additional, Jassal, Davinder S., additional, Jelic, Tom, additional, Lee, Dana, additional, Leipsic, Jonathon, additional, Leong-Poi, Howard, additional, Luksun, Warren, additional, Mulloy, Andrew J., additional, Mulvagh, Sharon, additional, Nesbitt, Gillian, additional, Promislow, Steven, additional, Sebag, Igal A., additional, Tran, Diem T.T., additional, and Tsang, Teresa S.M., additional

Published
2023
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5. Canadian Cardiovascular Society Guidelines for Evaluation and Management of Cardiovascular Complications of Cancer Therapy

Author

Virani, Sean A., Dent, Susan, Brezden-Masley, Christine, Clarke, Brian, Davis, Margot K., Jassal, Davinder S., Johnson, Christopher, Lemieux, Julie, Paterson, Ian, Sebag, Igal A., Simmons, Christine, Sulpher, Jeffrey, Thain, Kishore, Thavendiranathan, Paaldinesh, Wentzell, Jason R., Wurtele, Nola, Côté, Marc André, Fine, Nowell M., Haddad, Haissam, Hayley, Bradley D., Hopkins, Sean, Joy, Anil A., Rayson, Daniel, Stadnick, Ellamae, and Straatman, Lynn

Published
2016
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7. Socio-Economic Variations Determine the Clinical Presentation, Aetiology and Outcome of Infective Endocarditis: a Prospective Cohort Study from the ESC-EORP EURO-ENDO (European Infective Endocarditis) Registry

Author

Sengupta, Shantanu P, Prendergast, Bernard, Laroche, Cécile, Furnaz, Shumaila, Ronderos, Ricardo, Almaghraby, Abdallah, Asch, Federico M, Blechova, Kamila, Zaky, Hosam, Strahilevitz, Jacob, Dworakowski, Rafal, Miyasaka, Yoko, Sebag, Igal, Izumi, Chisato, Axler, Olivier, Jamiel, Abdulrahman, Philip, Mary, Campos Vieira, Marcelo Luiz, Lancellotti, Patrizio, Habib, Gilbert, P Gale, C, Beleslin, B, Budaj, A, Chioncel, O, Dagres, N, Danchin, N, Emberson, J, Erlinge, D, Glikson, M, Gray, A, Kayikcioglu, M, P Maggioni, A, K Nagy, V, Nedoshivin, A, A-S, Petronio, Roos-Hesselink, J, Wallentin, L, Zeymer, U, Habib, G, Lancellotti, P, Cosyns, B, Donal, E, Erba, P, Iung, B, A Popescu, B, Prendergast, B, Tornos, P, Andarala, M, Berle, C, Brunel-Lebecq, A, Fiorucci, E, Laroche, C, Missiamenou, V, Taylor, C, N Ali Tatar-Chentir, N, Al-Mallah, M, M Astrom Aneq, Athanassopoulos, G, P Badano, L, Benyoussef, S, E Calderon Aranda, M Cardim, N, K-L, Chan, Cruz, I, Edvardsen, T, Goliasch, G, Hagendorff, A, Hristova, K, Kamp, O, D-H, Kang, Kong, W, Matskeplishvili, S, Meshaal, M, Mirocevic, M, N Neskovic, A, Pazdernik, M, Plonska-Gosciniak, E, Raissouni, M, Ronderos, R, E Sade, L, Sadeghpour, A, Sambola, A, Sengupta, S, Separovic-Hanzevacki, J, Takeuchi, M, Tucay, E, C Tude Rodrigues, A, Varga, A, Vaskelyte, J, Yamagata, K, Yiangou, K, Zaky, H, Granada, I, Mahia, M, Ressi, S, Nacinovich, F, Iribarren, A, P Fernandez Oses, Avegliano, G, Filipini, E, Obregon, R, Bangher, M, Dho, J, Cartasegna, L, L Plastino, M, Novas, V, Shigel, C, Reyes, G, M De Santos, Gastaldello, N, M Granillo Fernandez, Potito, M, Streitenberger, G, Velazco, P, H Casabé, J, Cortes, C, Guevara, E, Salmo, F, Seijo, M, Weidinger, F, Heger, M, Brooks, R, Stöllberger, C, C-Y, Ho, Perschy, L, Puskas, L, Binder, C, Rosenhek, R, Schneider, M, M-P, Winter, Hoffer, E, Melissopoulou, M, Lecoq, E, Legrand, D, Jacquet, S, Massoz, M, Pierard, L, Marchetta, S, Dulgheru, R, D Emal, C, Oury, C, Droogmans, S, Kerkhove, D, Plein, D, Soens, L, Weytjens, C, Motoc, A, Roosens, B, Lemoine, I, Rodrigus, I, Paelinck, B, Amsel, B, Unger, P, Konopnicki, D, Beauloye, C, Pasquet, A, L Vanoverschelde, J, Pierard, S, Vancraeynest, D, Sinnaeve, F, L Andrade, J, Staszko, K, R Dos Santos Monteiro, H Miglioranza, M, L Shuha, D, Alcantara, M, Cravo, V, Fazzio, L, Felix, A, Iso, M, Musa, C, P Siciliano, A, F Villaca Filho, Rodrigues, A, Vilela, F, Braga, J, Silva, R, Rodrigues, D, Silva, L, Morhy, S, Fischer, C, Vieira, M, Afonso, T, Abreu, J, N Falcao, S, A Moises, V, Gouvea, A, J Mancuso, F, C Souza, A, Y Silva, C, João, G, S Abboud, C, R Bellio de Mattos Barretto, Ramos, A, Arnoni, R, E Assef, J, J Della Togna, D, D Le Bihan, Miglioli, L, P Romero Oliveira, A, R Tadeu Magro Kroll, Cortez, D, L Gelape, C, M D, C Peirira Nunes, C De Abreu Ferrari, T, Hay, K, V, Le, Page, M, Poulin, F, Sauve, C, Serri, K, Mercure, C, Beaudoin, J, Pibarot, P, A Sebag, I, G Rudski, L, Ricafort, G, Barsic, B, Krajinovic, V, Vargovic, M, Lovric, D, Reskovic-Luksic, V, Vincelj, J, S Jaksic Jurinjak, Yiannikourides, V, Ioannides, M, Pofaides, C, Masoura, V, Pudich, J, Linhart, A, Siranec, M, Marek, J, Blechova, K, Kamenik, M, Pelouch, R, Coufal, Z, Mikulica, M, Griva, M, Jancova, E, Mikulcova, M, Taborsky, M, Precek, J, Jecmenova, M, Latal, J, Widimsky, J, Butta, T, Machacek, S, Vancata, R, Spinar, J, Holicka, M, F Pow Chon Long, Anzules, N, A Bajana Carpio, Largacha, G, Penaherrera, E, Moreira, D, Mahfouz, E, Elsafty, E, Soliman, A, Zayed, Y, Aboulenein, J, Abdel-Hay, M, Almaghraby, A, Abdelnaby, M, Ahmed, M, Hammad, B, Saleh, Y, Zahran, H, Elgebaly, O, Saad, A, Ali, M, Zeid, A, R El Sharkawy, A Al Kholy, Doss, R, Osama, D, Rizk, H, Elmogy, A, Mishriky, M, Assayag, P, S El Hatimi, Hubert, S, J-P, Casalta, Gouriet, F, Arregle, F, Cammilleri, S, Tessonnier, L, Riberi, A, Botelho-Nevers, E, Gagneux-Brunon, A, Pierrard, R, Tulane, C, Campisi, S, J-F, Fuzellier, Detoc, M, Mehalla, T, Boutoille, D, S Lecompte, A, Lefebvre, M, Pattier, S, O Al Habash, Asseray-Madani, N, Biron, C, Brochard, J, Caillon, J, Cueff, C, T Le Tourneau, Lecomte, R, M Magali Michel, M, Orain, J, Delarue, S, M Le Bras, J-F, Faucher, Aboyans, V, Beeharry, A, Durox, H, Lacoste, M, Magne, J, Mohty, D, David, A, Pradel, V, Sierra, V, Neykova, A, Bettayeb, B, Elkentaoui, S, Tzvetkov, B, Landry, G, Strady, C, Ainine, K, Baumard, S, Brasselet, C, Tassigny, C, Valente-Pires, V, Lefranc, M, Hoen, B, Lefevre, B, Curlier, E, Callier, C, Fourcade, N, Jobic, Y, Ansard, S, R Le Berre, F Le Ven, M-C, Pouliquen, Prat, G, P Le Roux, Bouchart, F, Savoure, A, Alarcon, C, Chapuzet, C, Gueit, I, Tribouilloy, C, Bohbot, Y, Peugnet, F, Gun, M, Duval, X, Lescure, X, Ilic-Habensus, E, Sadoul, N, Selton-Suty, C, Alla, F, Goehringer, F, Huttin, O, Chevalier, E, Garcia, R, V Le Marcis, Tattevin, P, Flecher, E, Revest, M, Chirouze, C, Bouiller, K, Hustache-Mathieu, L, Klopfenstein, T, Moreau, J, Fournier, D, A-S, Brunel, Lim, P, Oliver, L, Ternacle, J, Moussafeur, A, Chavanet, P, Piroth, L, Salmon-Rousseau, A, Buisson, M, Mahy, S, Martins, C, Gohier, S, Axler, O, Baumann, F, Lebras, S, Piper, C, Guckel, D, Börgermann, J, Horstkotte, D, Winkelmann, E, Brockmeier, B, Grey, D, Nickenig, G, Schueler, R, Öztürk, C, Stöhr, E, Hamm, C, Walther, T, Brandt, R, A-C, Frühauf, T Hartung, C, Hellner, C, Wild, C, Becker, M, Hamada, S, Kaestner, W, Stangl, K, Knebel, F, Baldenhofer, G, Brecht, A, Dreger, H, Isner, C, Pfafflin, F, Stegemann, M, Zahn, R, Fraiture, B, Kilkowski, C, A-K, Karcher, Klinger, S, Tolksdorf, H, Tousoulis, D, Aggeli, C, Sideris, S, Venieri, E, Sarri, G, Tsiapras, D, Armenis, I, Koutsiari, A, Floros, G, Grassos, C, Dragasis, S, Rallidis, L, Varlamos, C, Michalis, L, Naka, K, Bechlioulis, A, Kotsia, A, Lakkas, L, Pappas, K, Papadopoulos, C, Kiokas, S, Lioni, A, Misailidou, S, Barbetseas, J, Bonou, M, Kapelios, C, Tomprou, I, Zerva, K, Manolis, A, Hamodraka, E, Athanasiou, D, Haralambidis, G, Samaras, H, Poulimenos, L, Nagy, A, Bartykowszki, A, Gara, E, Mungulmare, K, Kasliwal, R, Bansal, M, Ranjan, S, Bhan, A, Kyavar, M, Maleki, M, F Noohi Bezanjani, Alizadehasl, A, Boudagh, S, Ghavidel, A, Moradnejad, P, R Pasha, H, Ghadrdoost, B, Gilon, D, Strahilevitz, J, Wanounou, M, Israel, S, D'Agostino, C, Colonna, P, L De Michele, Fumarola, F, Stante, M, Marchionni, N, Scheggi, V, Alterini, B, S Del Pace, Stefano, P, Sparano, C, Ruozi, N, Tenaglia, R, Muraru, D, Limbruno, U, Cresti, A, Baratta, P, Solari, M, Giannattasio, C, Moreo, A, B De Chiara, B Lopez Montero, Musca, F, A Orcese, C, Panzeri, F, Spano, F, F Russo, C, Alfieri, O, M De Bonis, Chiappetta, S, B Del Forno, Ripa, M, Scarpellini, P, C Tassan Din, Castiglioni, B, Pasciuta, R, Carletti, S, Ferrara, D, Guffanti, M, Iaci, G, Lapenna, E, Nisi, T, Oltolini, C, Busnardo, E, Pajoro, U, Agricola, E, Meneghin, R, Schiavi, D, Piscione, F, Citro, R, M Benvenga, R, Greco, L, Soriente, L, Radano, I, Prota, C, Bellino, M, D Di Vece, Santini, F, Salsano, A, M Olivieri, G, Turrini, F, Messora, R, Tondi, S, Olaru, A, Agnoletto, V, Grassi, L, Leonardi, C, Sansoni, S, S Del Ponte, M Actis Dato, G, A De Martino, Ohte, N, Kikuchi, S, Wakami, K, Aonuma, K, Seo, Y, Ishizu, T, Machino-Ohtsuka, T, Yamamoto, M, Iida, N, Nakajima, H, Nakagawa, Y, Izumi, C, Amano, M, Miyake, M, Takahashi, K, Shiojima, I, Miyasaka, Y, Maeba, H, Suwa, Y, Taniguchi, N, Tsujimoto, S, Kitai, T, Ota, M, Yuda, S, Sasaki, S, Hagiwara, N, Yamazaki, K, Ashihara, K, Arai, K, Saitou, C, Saitou, S, Suzuki, G, Shibata, Y, Watanabe, N, Nishino, S, Ashikaga, K, Kuriyama, N, Mahara, K, Okubo, T, Fujimaki, H, Shitan, H, Yamamoto, H, Abe, K, Terada, M, Takanashi, S, Sata, M, Yamada, H, Kusunose, K, Saijo, Y, Seno, H, Yuichiro, O, Onishi, T, Sera, F, Nakatani, S, Mizuno, H, Sengoku, K, W Park, S, K Eun Kyoung, L Ga Yeon, J-W, Hwang, Jin-Oh, C, S-J, Park, Sang-Chol, L, Sung-A, C, Y Jang, S, Heo, R, Lee, S, J-M, Song, Jung, E, Plisiene, J, Dambrauskaite, A, Gruodyte, G, Jonkaitiene, R, Mizariene, V, Atkocaityte, J, Zvirblyte, R, Sow, R, Codreanu, A, Staub, T, Michaux, C, E C, L De la Vega, Jacobs-Orazi, L, C Mallia Azzopardi, G Xuereb, R, Piscopo, T, Farrugia, J, Fenech, M, Pllaha, E, Vella, C, Borg, D, Casha, R, Grib, L, Raevschi, E, Grejdieru, A, Kravcenco, D, Prisacari, E, Samohvalov, E, Samohvalov, S, Sceglova, N, Panfile, E, Cardaniuc, L, Corcea, V, Feodorovici, A, Gaina, V, Girbu, L, Jimbei, P, Balan, G, Cardaniuc, I, Benesco, I, Marian, V, Sumarga, N, Bozovic, B, Bulatovic, N, Lakovic, P, Music, L, Budde, R, Wahadat, A, Gamela, T, Meijers, T, P Van Melle, J, M Deursen, V, J Crijns, H, C Bekkers, S, C Cheriex, E, Gilbers, M, L Kietselaer, B, Knackstedt, C, Lorusso, R, Schalla, S, A Streukens, S, Chamuleau, S, M-J, Cramer, Teske, A, T Van der Spoel, Wind, A, Lokhorst, J, Liesbek, O, H Van Heusden, Tanis, W, I Van der Bilt, Vriend, J, H De Lange-van Bruggen, Karijodikoro, E, Riezebos, R, E van Dongen, Schoep, J, Stolk, V, T Offstad, J, O Beitnes, J, Helle-Valle, T, Skulstad, H, Skardal, R, Qamar, N, Furnaz, S, Ahmed, B, H Butt, M, F Khanzada, M, Saghir, T, Wahid, A, Hryniewiecki, T, Szymanski, P, Marzec, K, Misztal-Ogonowska, M, Kosmala, W, Przewlocka-Kosmala, M, Rojek, A, Woznicka, K, Zachwyc, J, Lisowska, A, Kaminska, M, D Kasprzak, J, Kowalczyk, E, F Strzecka, D, Wejner-Mik, P, Trabulo, M, Freitas, P, Ranchordas, S, Rodrigues, G, Pinto, P, Queiros, C, Azevedo, J, Marques, L, Seabra, D, Branco, L, Cruz, M, Galrinho, A, Moreira, R, Rio, P, T Timoteo, A, Selas, M, Carmelo, V, B Duque Neves, Pereira, H, Guerra, A, Marques, A, Pintassilgo, I, C Tomescu, M, N-M, Trofenciuc, Andor, M, Bordejevic, A, S Branea, H, Caruntu, F, A Velcean, L, Mavrea, A, F Onel, M, Parvanescu, T, Pop, D, L Pop-Moldovan, A, I Puticiu, M, Cirin, L, M Citu, I, A Cotoraci, C, Darabantiu, D, Farcas, R, Marincu, I, Ionac, A, Cozma, D, Mornos, C, Goanta, F, Popescu, I, Beyer, R, Mada, R, Rancea, R, Tomoaia, R, Rosianu, H, Stanescu, C, Kobalava, Z, Karaulova, J, Kotova, E, Milto, A, Pisaryuk, A, Povalyaev, N, Sorokina, M, Alrahimi, J, Elshiekh, A, Jamiel, A, Ahmed, A, Attia, N, Putnikovic, B, Dimic, A, Ivanovic, B, Matic, S, Trifunovic, D, Petrovic, J, Kosevic, D, Stojanovic, I, Petrovic, I, Dabic, P, Milojevic, P, Srdanovic, I, Susak, S, Velicki, L, Vulin, A, Kovacevic, M, Redzek, A, Stefanovic, M, C Yeo, T, W K, F Kong, K Poh, K, Vilacosta, I, Ferrera, C, Olmos, C, M Abd El Nasser, F Calvo Iglesias, Blanco-Gonzalez, E, M Bravo Amaro, Lopez-Rodriguez, E, J Lugo Adan, N Germinas, A, Pazos-Lopez, P, M Pereira Loureiro, T Perez, M, Raposeiras-Roubin, S, S Rasheed Yas, M-M, Suarez-Varela, F Vasallo Vidal, Garcia-Dorado, D, Fernandez-Hidalgo, N, Gonzalez-Alujas, T, Lozano, J, Maisterra, O, Pizzi, N, Rios, R, Bayes-Genis, A, L Pedro Botet, Vallejo, N, Llibre, C, Mateu, L, Nunez, R, Quesada, D, Berastegui, E, D Bosch Portell, J Aboal Vinas, X Albert Bertran, R Brugada Tarradellas, P Loma-Osorio Ricon, C Tiron de Llano, A Arnau, M, Bel, A, Blanes, M, Osa, A, Anguita, M, Carrasco, F, C Castillo, J, L Zamorano, J, L Moya Mur, J, Alvaro, M, Fernandez-Golfin, C, M Monteagudo, J, E Navas Elorza, C Farinas Alvarez, M, J Aguero Balbin, Zarauza, J, F Gutierrez-Diez, J, Arminanzas, C, F Arnaiz de Las Revillas, A Arnaiz Garcia, M Cobo Belaustegui, M Fernandez Sampedro, M Gutierrez Cuadra, L Garcia Cuello, C Gonzalez Rico, Rodriguez-Alvarez, R, Goikoetxea, J, Montejo, M, M Miro, J, Almela, M, Ambrosioni, J, Moreno, A, Quintana, E, Sandoval, E, Tellez, A, M Tolosana, J, Vidal, B, Falces, C, Fuster, D, Garcia-de-la-Maria, C, Hernandez-Meneses, M, Llopis, J, Marco, F, Ruiz-Zamora, I, A Bardaji Ruiz, E Sanz Girgas, Garcia-Pardo, G, M Guillen Marzo, A Rodriguez Oviedo, A Villares Jimenez, Abid, L, Hammami, R, Kammoun, S, S Mourali, M, F Mghaieth Zghal, M Ben Hlima, Boudiche, S, Ouali, S, Zakhama, L, Antit, S, Slama, I, Gulel, O, Sahin, M, Karacaglar, E, Kucukoglu, S, Cetinarslan, O, S Yasar, U, Canpolat, U, Mutlu, B, Atas, H, Dervishova, R, Ileri, C, Alhashmi, J, Tahir, J, Zarger, P, Baslib, F, Woldman, S, Menezes, L, Primus, C, Uppal, R, Bvekerwa, I, Chandrasekaran, B, Kopanska, A, Chambers, J, Hancock, J, Klein, J, Rajani, R, P Ursi, M, Cannata, S, Dworakowski, R, Fife, A, Breeze, J, Browne-Morgan, M, Gunning, M, Streather, S, M Asch, F, Zemedkun, M, Alyavi, B, Uzokov, J, Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Département de Cardiologie [Hôpital de la Timone - APHM], Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), CHU Pontchaillou [Rennes], ARN régulateurs bactériens et médecine (BRM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), 2011–21, Abbott Vascular, 2009–18, Amgen, 2016–19, Edwards, 2014–16, Gedeon Richter, 2009–12, Menarini Group, 2011–14, MSD, 2014–20, Novartis Pharma, 2014–16, ResMed Foundation, 2009–11, Sanofi, 2009–21, Servier, 2019–22, Vifor Pharma, 2014–21, AstraZeneca, 2009–18, Bayer AG, 2009–19, Boehringer Ingelheim, 2009–12, Boston Scientific, Bristol Myers Squibb, 2011–19, Pfizer Alliance, 2011–20, Daiichi Sankyo Company, 2014–17, Eli Lilly and Company, Sengupta, S, Prendergast, B, Laroche, C, Furnaz, S, Ronderos, R, Almaghraby, A, Asch, F, Blechova, K, Zaky, H, Strahilevitz, J, Dworakowski, R, Miyasaka, Y, Sebag, I, Izumi, C, Axler, O, Jamiel, A, Philip, M, Vieira, M, Lancellotti, P, Habib, G, Gale, C, Beleslin, B, Budaj, A, Chioncel, O, Dagres, N, Danchin, N, Emberson, J, Erlinge, D, Glikson, M, Gray, A, Kayikcioglu, M, Maggioni, A, Nagy, V, Nedoshivin, A, Petronio, A, Roos-Hesselink, J, Wallentin, L, Zeymer, U, Cosyns, B, Donal, E, Erba, P, Iung, B, Popescu, B, Tornos, P, Andarala, M, Berle, C, Brunel-Lebecq, A, Fiorucci, E, Missiamenou, V, Taylor, C, Ali Tatar-Chentir, N, Al-Mallah, M, Astrom Aneq, M, Athanassopoulos, G, Badano, L, Benyoussef, S, Calderon Aranda, E, Cardim, N, Chan, K, Cruz, I, Edvardsen, T, Goliasch, G, Hagendorff, A, Hristova, K, Kamp, O, Kang, D, Kong, W, Matskeplishvili, S, Meshaal, M, Mirocevic, M, Neskovic, A, Pazdernik, M, Plonska-Gosciniak, E, Raissouni, M, Sade, L, Sadeghpour, A, Sambola, A, Separovic-Hanzevacki, J, Takeuchi, M, Tucay, E, Tude Rodrigues, A, Varga, A, Vaskelyte, J, Yamagata, K, Yiangou, K, Granada, I, Mahia, M, Ressi, S, Na-Cinovich, F, Iribarren, A, Fernandez Oses, P, Avegliano, G, Filipini, E, Obregon, R, Bangher, M, Dho, J, Cartasegna, L, Plastino, M, Novas, V, Shigel, C, Reyes, G, De Santos, M, Gastaldello, N, Granillo Fernandez, M, Potito, M, Streit-Enberger, G, Velazco, P, Casabe, J, Cortes, C, Guevara, E, Salmo, F, Seijo, M, Weidinger, F, Heger, M, Brooks, R, Stollberger, C, Ho, C, Perschy, L, Puskas, L, Binder, C, Rosenhek, R, Schneider, M, Winter, M, Hoffer, E, Melis-Sopoulou, M, Lecoq, E, Legrand, D, Jacquet, S, Massoz, M, Pierard, L, Marchetta, S, Dulgheru, R, D'Emal, C, Oury, C, Droog-Mans, S, Kerkhove, D, Plein, D, Soens, L, Weytjens, C, Motoc, A, Roosens, B, Lemoine, I, Rodrigus, I, Paelinck, B, Am-Sel, B, Unger, P, Konopnicki, D, Beauloye, C, Pasquet, A, Vanoverschelde, J, Pierard, S, Vancraeynest, D, Sinnaeve, F, Andrade, J, Staszko, K, Dos Santos Monteiro, R, Miglioranza, M, Shuha, D, Alcantara, M, Cravo, V, Fazzio, L, Felix, A, Iso, M, Musa, C, Siciliano, A, Villaca Filho, F, Rodrigues, A, Vilela, F, Braga, J, Silva, R, Rodrigues, D, Silva, L, Morhy, S, Fischer, C, Afonso, T, Abreu, J, Falcao, S, Moises, V, Gou-Vea, A, Mancuso, F, Souza, A, Silva, C, Joao, G, Abboud, C, Bellio de Mattos Barretto, R, Ramos, A, Arnoni, R, Assef, J, Della Togna, D, Le Bihan, D, Miglioli, L, Romero Oliveira, A, Tadeu Magro Kroll, R, Cortez, D, Gelape, C, Peirira Nunes, M, De Abreu Ferrari, T, Hay, K, Le, V, Page, M, Poulin, F, Sauve, C, Serri, K, Mercure, C, Beaudoin, J, Pibarot, P, Rudski, L, Ricafort, G, Barsic, B, Krajinovic, V, Vargovic, M, Lovric, D, Reskovic-Luksic, V, Vincelj, J, Jaksic Jurinjak, S, Yiannikourides, V, Ioannides, M, Pofaides, C, Masoura, V, Pudich, J, Linhart, A, Siranec, M, Marek, J, Kamenik, M, Pelouch, R, Coufal, Z, Mikulica, M, Griva, M, Jancova, E, Mikulcova, M, Taborsky, M, Precek, J, Jecmenova, M, Latal, J, Widimsky, J, Butta, T, Machacek, S, Vancata, R, Spinar, J, Holicka, M, Pow Chon Long, F, Anzules, N, Bajana Carpio, A, Largacha, G, Penaherrera, E, Moreira, D, Mahfouz, E, Elsafty, E, Soliman, A, Zayed, Y, Aboulenein, J, Abdel-Hay, M, Abdelnaby, M, Ahmed, M, Hammad, B, Saleh, Y, Zahran, H, El-Gebaly, O, Saad, A, Ali, M, Zeid, A, El Sharkawy, R, Al Kholy, A, Doss, R, Osama, D, Rizk, H, Elmogy, A, Mishriky, M, Assayag, P, El Hatimi, S, Hubert, S, Casalta, J, Gouriet, F, Arregle, F, Cammilleri, S, Tessonnier, L, Riberi, A, Botelho-Nevers, E, Gagneux-Brunon, A, Pierrard, R, Tulane, C, Campisi, S, Fuzellier, J, Detoc, M, Mehalla, T, Boutoille, D, Lecompte, A, Lefebvre, M, Pattier, S, Al Habash, O, Asseray-Madani, N, Biron, C, Brochard, J, Caillon, J, Cueff, C, Le Tourneau, T, Lecomte, R, Magali Michel, M, Orain, J, Delarue, S, Le Bras, M, Faucher, J, Aboyans, V, Bee-Harry, A, Durox, H, Lacoste, M, Magne, J, Mohty, D, David, A, Pradel, V, Sierra, V, Neykova, A, Bettayeb, B, Elkentaoui, S, Tzvetkov, B, Landry, G, Strady, C, Ainine, K, Baumard, S, Brasselet, C, Tassigny, C, Valente-Pires, V, Lefranc, M, Hoen, B, Lefevre, B, Curlier, E, Callier, C, Fourcade, N, Jobic, Y, Ansard, S, Le Berre, R, Le Ven, F, Pouliquen, M, Prat, G, Le Roux, P, Bouchart, F, Savoure, A, Alarcon, C, Chapuzet, C, Gueit, I, Tribouilloy, C, Bohbot, Y, Peugnet, F, Gun, M, Duval, X, Lescure, X, Ilic-Habensus, E, Sadoul, N, Selton-Suty, C, Alla, F, Goehringer, F, Huttin, O, Chevalier, E, Garcia, R, Le Marcis, V, Tattevin, P, Flecher, E, Revest, M, Chirouze, C, Bouiller, K, Hustache-Mathieu, L, Klopfenstein, T, Moreau, J, Fournier, D, Brunel, A, Lim, P, Oliver, L, Ternacle, J, Moussafeur, A, Chavanet, P, Piroth, L, Salmon-Rousseau, A, Buisson, M, Mahy, S, Martins, C, Go-Hier, S, Baumann, F, Lebras, S, Piper, C, Guckel, D, Borgermann, J, Horstkotte, D, Winkelmann, E, Brockmeier, B, Grey, D, Nick-Enig, G, Schueler, R, Ozturk, C, Stohr, E, Hamm, C, Walther, T, Brandt, R, Fruhauf, A, Hartung, C, Hellner, C, Wild, C, Becker, M, Hamada, S, Kaestner, W, Stangl, K, Knebel, F, Baldenhofer, G, Brecht, A, Dreger, H, Isner, C, Pfafflin, F, Stegemann, M, Zahn, R, Fraiture, B, Kilkowski, C, Karcher, A, Klinger, S, Tolksdorf, H, Tousoulis, D, Aggeli, C, Sideris, S, Venieri, E, Sarri, G, Tsiapras, D, Armenis, I, Koutsiari, A, Floros, G, Grassos, C, Dragasis, S, Rallidis, L, Varlamos, C, Michalis, L, Naka, K, Bechlioulis, A, Kotsia, A, Lakkas, L, Pappas, K, Papadopoulos, C, Kiokas, S, Lioni, A, Misailidou, S, Bar-Betseas, J, Bonou, M, Kapelios, C, Tomprou, I, Zerva, K, Manolis, A, Hamodraka, E, Athanasiou, D, Haralambidis, G, Samaras, H, Poulimenos, L, Nagy, A, Bartykowszki, A, Gara, E, Mungulmare, K, Kasliwal, R, Bansal, M, Ranjan, S, Bhan, A, Kyavar, M, Maleki, M, Noohi Bezanjani, F, Alizadehasl, A, Boudagh, S, Ghavidel, A, Morad-Nejad, P, Pasha, H, Ghadrdoost, B, Gilon, D, Wanounou, M, Israel, S, D'Agostino, C, Colonna, P, De Michele, L, Fumarola, F, Stante, M, Mar-Chionni, N, Scheggi, V, Alterini, B, Del Pace, S, Stefano, P, Sparano, C, Ruozi, N, Tenaglia, R, Muraru, D, Limbruno, U, Cresti, A, Baratta, P, Solari, M, Giannattasio, C, Moreo, A, De Chiara, B, Lopez Montero, B, Musca, F, Orcese, C, Panzeri, F, Spano, F, Russo, C, Alferi, O, De Bonis, M, Chiappetta, S, Del Forno, B, Ripa, M, Scarpellini, P, Tassan Din, C, Castiglioni, B, Pasci-Uta, R, Carletti, S, Ferrara, D, Guffanti, M, Iaci, G, Lapenna, E, Nisi, T, Oltolini, C, Busnardo, E, Pajoro, U, Agricola, E, Meneghin, R, Schiavi, D, Piscione, F, Citro, R, Benvenga, R, Greco, L, Soriente, L, Radano, I, Prota, C, Bellino, M, Di Vece, D, Santini, F, Salsano, A, Olivieri, G, Turrini, F, Messora, R, Tondi, S, Olaru, A, Agnoletto, V, Grassi, L, Leonardi, C, Sansoni, S, Del Ponte, S, Actis Dato, G, De Martino, A, Ohte, N, Kikuchi, S, Wakami, K, Aonuma, K, Seo, Y, Ishizu, T, Machino-Ohtsuka, T, Yamamoto, M, Iida, N, Nakajima, H, Nakagawa, Y, Amano, M, Miyake, M, Takahashi, K, Shiojima, I, Maeba, H, Suwa, Y, Taniguchi, N, Tsujimoto, S, Kitai, T, Ota, M, Yuda, S, Sasaki, S, Hagiwara, N, Yamazaki, K, Ashihara, K, Arai, K, Saitou, C, Saitou, S, Suzuki, G, Shibata, Y, Watanabe, N, Nishino, S, Ashikaga, K, Kuriyama, N, Mahara, K, Okubo, T, Fujimaki, H, Shi-Tan, H, Yamamoto, H, Abe, K, Terada, M, Takanashi, S, Sata, M, Yamada, H, Kusunose, K, Saijo, Y, Seno, H, Yuichiro, O, Onishi, T, Sera, F, Nakatani, S, Mizuno, H, Sengoku, K, Park, S, Eun Kyoung, K, Ga Yeon, L, Hwang, J, Jin-Oh, C, Sang-Chol, L, Sung-A, C, Jang, S, Heo, R, Lee, S, Song, J, Jung, E, Plisiene, J, Dambrauskaite, A, Gruodyte, G, Jonkaitiene, R, Mizariene, V, Atkocaityte, J, Zvirblyte, R, Sow, R, Codreanu, A, Staub, T, Michaux, C, De la Vega, E, Jacobs-Orazi, L, Mallia Azzopardi, C, Xuereb, R, Pis-Copo, T, Farrugia, J, Fenech, M, Pllaha, E, Vella, C, Borg, D, Casha, R, Grib, L, Raevschi, E, Gre-Jdieru, A, Kravcenco, D, Prisacari, E, Samohvalov, E, Samohvalov, S, Sceglova, N, Panfle, E, Cardaniuc, L, Corcea, V, Feodorovici, A, Gaina, V, Girbu, L, Jimbei, P, Balan, G, Cardaniuc, I, Benesco, I, Marian, V, Sumarga, N, Bozovic, B, Bulatovic, N, Lakovic, P, Music, L, Budde, R, Waha-Dat, A, Gamela, T, Meijers, T, Van Melle, J, Deursen, V, Crijns, H, Bekkers, S, Cheriex, E, Gilbers, M, Kietselaer, B, Knackstedt, C, Lorusso, R, Schalla, S, Streukens, S, Chamuleau, S, Cramer, M, Teske, A, Van der Spoel, T, Wind, A, Lokhorst, J, Liesbek, O, Van Heusden, H, Tanis, W, Van der Bilt, I, Vriend, J, De Lange-Van Bruggen, H, Karijodikoro, E, Riezebos, R, van Dongen, E, Schoep, J, Stolk, V, Offstad, J, Beitnes, J, Helle-Valle, T, Skulstad, H, Skardal, R, Qamar, N, Ahmed, B, Butt, M, Khanzada, M, Saghir, T, Wahid, A, Hryniewiecki, T, Szymanski, P, Marzec, K, Misztal-Ogonowska, M, Kosmala, W, Przewlocka-Kosmala, M, Rojek, A, Woznicka, K, Zachwyc, J, Lisowska, A, Kamin-Ska, M, Kasprzak, J, Kowalczyk, E, Strzecka, D, Wejner-Mik, P, Trabulo, M, Freitas, P, Ranchordas, S, Rodrigues, G, Pinto, P, Queiros, C, Azevedo, J, Marques, L, Seabra, D, Branco, L, Cruz, M, Galrinho, A, Moreira, R, Rio, P, Timoteo, A, Selas, M, Carmelo, V, Duque Neves, B, Pereira, H, Guerra, A, Marques, A, Pintassilgo, I, Tomescu, M, Trofenciuc, N, Andor, M, Bordejevic, A, Branea, H, Caruntu, F, Velcean, L, Mavrea, A, Onel, M, Parvanescu, T, Pop, D, Pop-Moldovan, A, Puticiu, M, Cirin, L, Citu, I, Cotoraci, C, Darabantiu, D, Farcas, R, Marincu, I, Ionac, A, Cozma, D, Mornos, C, Goanta, F, Popescu, I, Beyer, R, Mada, R, Rancea, R, Tomoaia, R, Rosianu, H, Stanescu, C, Kobalava, Z, Karaulova, J, Ko-Tova, E, Milto, A, Pisaryuk, A, Povalyaev, N, Sorokina, M, Alrahimi, J, Elshiekh, A, Ahmed, A, Attia, N, Putnikovic, B, Dimic, A, Ivanovic, B, Matic, S, Trifunovic, D, Petrovic, J, Kosevic, D, Stojanovic, I, Petrovic, I, Dabic, P, Milojevic, P, Srdanovic, I, Susak, S, Velicki, L, Vulin, A, Kovacevic, M, Redzek, A, Stefanovic, M, Yeo, T, Poh, K, Vi-Lacosta, I, Ferrera, C, Olmos, C, Abd El-Nasser, M, Calvo Iglesias, F, Bianco-Gonzalez, E, Bravo Amaro, M, Lopez-Rodriguez, E, Lugo Adan, J, Germinas, A, Pazos-Lopez, P, Pereira Loureiro, M, Perez, M, Raposeiras-Roubin, S, Rasheed Yas, S, Suarez-Varela, M, Vasallo Vidal, F, Garcia-Dorado, D, Fernandez-Hidalgo, N, Gonzalez-Alujas, T, Lozano, J, Maisterra, O, Pizzi, N, Rios, R, Bayes-Genis, A, Pedro Botet, L, Vallejo, N, Llibre, C, Mateu, L, Nunez, R, Quesada, D, Berastegui, E, Bosch Portell, D, Aboal Vinas, J, Albert Bertran, X, Brugada Tar-Radellas, R, Loma-Osorio Ricon, P, Tiron de Llano, C, Arnau, M, Bel, A, Blanes, M, Osa, A, Anguita, M, Carrasco, F, Castillo, J, Zamorano, J, Moya Mur, J, Alvaro, M, Fernandez-Golfin, C, Monteagudo, J, Navas Elorza, E, Farinas Alvarez, M, Aguero Balbin, J, Zarauza, J, Gutierrez-Diez, J, Arminanzas, C, Arnaiz de las Revillas, F, Arnaiz Garcia, A, Cobo Belaustegui, M, Fernandez Sampedro, M, Gutierrez Cuadra, M, Garcia Cuello, L, Gonzalez Rico, C, Rodriguez-Alvarez, R, Goikoetxea, J, Montejo, M, Miro, J, Almela, M, Ambrosioni, J, Moreno, A, Quintana, E, Sandoval, E, Tellez, A, Tolosana, J, Vidal, B, Falces, C, Fuster, D, Garcia-De-la-Maria, C, Hernandez-Meneses, M, Llopis, J, Marco, F, Ruiz-Zamora, I, Bardaji Ruiz, A, Sanz Girgas, E, Garcia-Pardo, G, Guillen Marzo, M, Rodriguez Oviedo, A, Villares Jimenez, A, Abid, L, Ham-Mami, R, Kammoun, S, Mourali, M, Mghaieth Zghal, F, Ben Hlima, M, Boudiche, S, Ouali, S, Zakhama, L, Antit, S, Slama, I, Gulel, O, Sahin, M, Karacaglar, E, Kucukoglu, S, Cetinarslan, O, Sinan, U, Canpolat, U, Mutlu, B, Atas, H, Dervishova, R, Ileri, C, Alhashmi, J, Tahir, J, Zarger, P, Baslib, F, Woldman, S, Menezes, L, Primus, C, Uppal, R, Bvekerwa, I, Chandrasekaran, B, Kopanska, A, Chambers, J, Hancock, J, Klein, J, Rajani, R, Ursi, M, Cannata, S, Fife, A, Breeze, J, Browne-Morgan, M, Gunning, M, Streather, S, Zemedkun, M, Alyavi, B, and Uzokov, J

Subjects
Socioeconomic, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, Endocarditis, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Health Policy, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Socio-economic, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, Endocarditi, Cardiology and Cardiovascular Medicine, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
Abstract

Aims Infective endocarditis (IE) is a life-threatening disease associated with high mortality and morbidity worldwide. We sought to determine how socioeconomic factors might influence its epidemiology, clinical presentation, investigation and management, and outcome, in a large international multicentre registry. Methods and results The EurObservational Programme (EORP) of the European Society of Cardiology EURO-ENDO (European Infective Endocarditis) registry comprises a prospective cohort of 3113 adult patients admitted for IE in 156 hospitals in 40 countries between January 2016 and March 2018. Patients were separated in three groups, according to World Bank economic stratification [group 1: high income (75.6%); group 2: upper-middle income (15.4%); group 3: lower-middle income (9.1%)]. Group 3 patients were younger [median age (interquartile range, IQR): group 1, 66 (53–75) years; group 2, 57 (41–68) years; group 3, 33 (26–43) years; P < 0.001] with a higher frequency of smokers, intravenous drug use, and human immunodeficiency virus infection (all P < 0.001) and presented later [median (IQR) days since symptom onset: group 1, 12 (3–35); group 2, 19 (6–54); group 3, 31 (12–62); P < 0.001] with a higher likelihood of developing congestive heart failure (13.6%, 11.1%, and 22.6%, respectively; P < 0.001) and persistent fever (9.8%, 14.2%, and 27.9%, respectively; P < 0.001). Among 2157 (69.3%) patients with theoretical indication for cardiac surgery, surgery was performed less frequently in group 3 patients (75.5%, 76.8%, and 51.3%, respectively; P < 0.001), who also demonstrated the highest mortality (15.0%, 23.0%, and 23.7%, respectively; P < 0.001). Conclusion Socioeconomic factors influence the clinical profile of patients presenting with IE across the world. Despite younger age, patients from the poorest countries presented with more frequent complications and higher mortality associated with delayed diagnosis and lower use of surgery.

Published
2022

8. Socioeconomic variations determine the clinical presentation, aetiology, and outcome of infective endocarditis: a prospective cohort study from the ESC-EORP EURO-ENDO (European Infective Endocarditis) registry

Author

Sengupta, Shantanu P, primary, Prendergast, Bernard, additional, Laroche, Cécile, additional, Furnaz, Shumaila, additional, Ronderos, Ricardo, additional, Almaghraby, Abdallah, additional, Asch, Federico M, additional, Blechova, Kamila, additional, Zaky, Hosam, additional, Strahilevitz, Jacob, additional, Dworakowski, Rafal, additional, Miyasaka, Yoko, additional, Sebag, Igal, additional, Izumi, Chisato, additional, Axler, Olivier, additional, Jamiel, Abdulrahman, additional, Philip, Mary, additional, Campos Vieira, Marcelo Luiz, additional, Lancellotti, Patrizio, additional, and Habib, Gilbert, additional

Published
2022
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11. Transcatheter heart valve failure: a systematic review

Author

Mylotte, Darren, Andalib, Ali, Thériault-Lauzier, Pascal, Dorfmeister, Magdalena, Girgis, Mina, Alharbi, Waleed, Chetrit, Michael, Galatas, Christos, Mamane, Samuel, Sebag, Igal, Buithieu, Jean, Bilodeau, Luc, de Varennes, Benoit, Lachapelle, Kevin, Lange, Ruediger, Martucci, Giuseppe, Virmani, Renu, and Piazza, Nicolo

Published
2015
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13. The impact of doxorubicin and dexrazoxane injection of prepubertal female rats on pregnancy outcome and cardiac function postpartum

Author

Calve, Annie, Noiles, William, Sebag, Igal A., and Chalifour, Lorraine E.

Subjects
Cancer survivors -- Health aspects, Pregnancy -- Health aspects, Echocardiography -- Usage, Anthracyclines -- Health aspects, Doxorubicin -- Health aspects, Heart failure -- Diagnosis, Biological sciences
Abstract

Childhood cancer survivors can develop significant cardiac dysfunction in adulthood as a consequence of their cancer treatment. Studies have linked heart failure during pregnancy to childhood doxorubicin (DOX) exposure. We hypothesized that DOX injection would reduce cardiac function peripartum and that DOX-treated dams would show greater cardiac remodeling postweaning. Weanling female Sprague-Dawley rats were injected with phospate-buffered saline, DOX (3 mg/kg), or DOX plus the cardioprotectant dexrazoxane (DEX; 60 mg/kg) and followed for 2 pregnancies. DOX and DOX:DEX dams were fertile, but had fewer pups and more pup losses. Echocardiography, 1-day postpartum after each pregnancy, revealed greater increases in cardiac mass and eccentric hypertrophy in DOX-treated dams and early dilation in DOX:DEX dams. The expression of calcium homeostasis proteins can change after DOX treatment and cardiac remodeling. SERCA2a expression did not change. Reductions in phospholamban and phospho-serine 16-specific phospholamban expression in DOX dams were not relieved by DEX coinjection. DOX binds and inactivates calsequestrin 2 expression so increased calsequestrin 2 expression in DOX:DEX-treated dams suggests some DEX compensation. The eccentric hypertrophy and dilation development, despite compensatory changes in proteins controlling calcium cycling, suggest DOX damage with repeat pregnancy that was not alleviated fully by DEX. Key words: Sprague-Dawley rat, pregnancy, echocardiography, SERCA2a, phospholamban, calsequestrin 2. Les survivants d'un cancer pediatrique peuvent developper une dysfonction cardiaque importante en consequence a leur traitement contre le cancer. Des etudes ont relie l'insuffisance cardiaque lors de la grossesse a une exposition a la doxorubicine (DOX) durant l'enfance. Nous avons emis l'hypothese que l'injection de DOX reduirait la fonction cardiaque peri-partum et que les meres traitees a la DOX montreraient un accroissement du remodelage cardiaque apres le sevrage. Des rats femelles Sprague Dawley sevrees ont recu une injection de PBS, de DOX seule (3 mg/kg) ou de DOX et du cardioprotecteur dexrazoxane (DEX, 60 mg/kg), traitements suivis de deux gestations. Les meres des groupes DOX et DOX :DEX etaient fertiles mais leurs portees etaient plus petites et la mortalite a la naissance plus elevee. L'echocardiographie effectuee un jour post-partum apres chaque gestation, revelait des augmentations plus elevees de la masse cardiaque et une hypertrophie excentrique chez les meres traitees a la DOX et une dilatation precoce chez les meres traitees au DOX : DEX. L'expression de proteines de l'homeostasie du calcium peut changer a la suite du traitement a la DOX et du remodelage cardiaque. L'expression de SERCA2a ne changeait pas. Des reductions de l'expression de phospholamban (PLB) et de [pS.sup.16]-PLB chez les meres du groupe DOX n'etaient pas affectees par la co-injection de DEX. La DOX lie et inactive la calsequestrine 2 (CSQ2) faisant en sorte que l'augmentation de l'expression de CSQ2 chez les meres traitees au DOX :DEX suggere une certaine compensation par le DEX. L'hypertrophie excentrique et le developpement de la dilatation, malgre les changements compensateurs dans les proteines controlant le cycle du calcium suggerent que la DOX induit un dommage lors de gestations repetees qui n'etait pas attenue completement par le DEX. Mots-cles : rat Sprague-Dawley, gestation, echocardiographie, SERCA2a, phospholamban, calsequestrine 2. [Traduit par la Redaction], Introduction Many childhood cancer survivors have at least one chronic illness (Oeffinger et al. 2006; Diller 2011; Trachtenberg et al. 2011). Reductions in cardiac function may be due to anthracycline-induced [...]

Published
2012
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14. Expert consensus for multimodality imaging evaluation of adult patients during and after cancer therapy: a report from the American Society of Echocardiography and the European Association of Cardiovascular Imaging

Author

Plana, Juan Carlos, Galderisi, Maurizio, Barac, Ana, Ewer, Michael S., Ky, Bonnie, Scherrer-Crosbie, Marielle, Ganame, Javier, Sebag, Igal A., Agler, Deborah A., Badano, Luigi P., Banchs, Jose, Cardinale, Daniela, Carver, Joseph, Cerqueira, Manuel, DeCara, Jeanne M., Edvardsen, Thor, Flamm, Scott D., Force, Thomas, Griffin, Brian P., Jerusalem, Guy, Liu, Jennifer E., Magalhães, Andreia, Marwick, Thomas, Sanchez, Liza Y., Sicari, Rosa, Villarraga, Hector R., and Lancellotti, Patrizio

Published
2014
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15. Socioeconomic variations determine the clinical presentation, aetiology, and outcome of infective endocarditis: a prospective cohort study from the ESC-EORP EURO-ENDO (European Infective Endocarditis) registry

Author

Sengupta, Shantanu P, Prendergast, Bernard, Laroche, Cécile, Furnaz, Shumaila, Ronderos, Ricardo, Almaghraby, Abdallah, Asch, Federico M, Blechova, Kamila, Zaky, Hosam, Strahilevitz, Jacob, Dworakowski, Rafal, Miyasaka, Yoko, Sebag, Igal, Izumi, Chisato, Axler, Olivier, Jamiel, Abdulrahman, Philip, Mary, Campos Vieira, Marcelo Luiz, Lancellotti, Patrizio, and Habib, Gilbert

Published
2023
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17. Age-related changes in lamin A/C expression in cardiomyocytes

Author

Afilalo, Jonathan, Sebag, Igal A., Chalifour, Lorraine E., Rivas, Daniel, Akter, Rahima, Sharma, Kamal, and Duque, Gustavo

Subjects
Heart cells -- Research, Cytoplasmic filaments -- Research, Cellular control mechanisms -- Research, Cardiovascular research, Biological sciences
Abstract

Lamin A and C (A/C) are type V intermediate filaments that form the nuclear lamina. Lamin A/C mutations lead to reduced expression of lamin A/C and diverse phenotypes such as familial cardiomyopathies and accelerated aging syndromes. Normal aging is associated with reduced expression of lamin A/C in osteoblasts and dermal fibroblasts but has never been assessed in cardiomyocytes. Our objective was to compare the expression of lamin A/C in cardiomyocytes of old (24 too) versus young (4 mo) C57B1/6J mice using a well-validated mouse model of aging. Lamin B1 was used as a control. Immunohistochemical and immunofluorescence analyses showed reduced expression of lamin A/C in cardiomyocyte nuclei of old mice (proportion of nuclei expressing lamin A/C, 9% vs. 62%, P < 0.001). Lamin A/C distribution was scattered peripherally and perinuclear in old mice, whereas it was homogeneous throughout the nuclei in young mice. Western blot analyses confirmed reduced expression of lamin A/C in nuclear extracts of old mice (ratio of lamin A/C to B1, 0.6 vs. 1.2, P < 0.01). Echocardiographic studies showed increased left ventricular wall thickness with preserved cavity size (concentric remodeling), increased left ventricular mass, and a slight reduction in fractional shortening in old mice. This is the first study to show that normal aging is associated with reduced expression and altered distribution of lamin A/C in nuclei of cardiomyocytes. aging; laminopathy; nucleus; cardiomyopathy

Published
2007

18. Expert Consensus for Multi-Modality Imaging Evaluation of Cardiovascular Complications of Radiotherapy in Adults: A Report from the European Association of Cardiovascular Imaging and the American Society of Echocardiography

Author

Lancellotti, Patrizio, Nkomo, Vuyisile T., Badano, Luigi P., Bergler, Jutta, Bogaert, Jan, Davin, Laurent, Cosyns, Bernard, Coucke, Philippe, Dulgheru, Raluca, Edvardsen, Thor, Gaemperli, Oliver, Galderisi, Maurizio, Griffin, Brian, Heidenreich, Paul A., Nieman, Koen, Plana, Juan C., Port, Steven C., Scherrer-Crosbie, Marielle, Schwartz, Ronald G., Sebag, Igal A., Voigt, Jens-Uwe, Wann, Samuel, and Yang, Phillip C.

Published
2013
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29. Longitudinal Changes in Multiple Biomarkers Are Associated with Cardiotoxicity in Breast Cancer Patients Treated with Doxorubicin, Taxanes, and Trastuzumab

Author

Putt, Mary, primary, Hahn, Virginia Shalkey, primary, Januzzi, James L, primary, Sawaya, Heloisa, primary, Sebag, Igal A, primary, Plana, Juan Carlos, primary, Picard, Michael H, primary, Carver, Joseph R, primary, Halpern, Elkan F, primary, Kuter, Irene, primary, Passeri, Jonathan, primary, Cohen, Victor, primary, Banchs, Jose, primary, Martin, Randolph P, primary, Gerszten, Robert E, primary, Scherrer-Crosbie, Marielle, primary, and Ky, Bonnie, primary

Published
2015
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30. LONGITUDINAL CHANGES IN MULTIPLE BIOMARKERS ARE ASSOCIATED WITH CARDIOTOXICITY IN BREAST CANCER PATIENTS TREATED WITH DOXORUBICIN, TAXANES AND TRASTUZUMAB

Author

Hahn, Virginia Shalkey, primary, Putt, Mary, additional, Sawaya, Heloisa, additional, Januzzi, James, additional, Sebag, Igal A., additional, Plana, Juan, additional, Picard, Michael, additional, Gerszten, Robert, additional, Halpern, Elkan, additional, Kuter, Irene, additional, Martin, Randolph, additional, Carver, Joseph, additional, Scherrer-Crosbie, Marielle, additional, and Ky, Bonnie, additional

Published
2015
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31. Expert Consensus for Multimodality Imaging Evaluation of Adult Patients during and after Cancer Therapy: A Report from the American Society of Echocardiography and the European Association of Cardiovascular Imaging

Author

Plana, Juan Carlos, primary, Galderisi, Maurizio, additional, Barac, Ana, additional, Ewer, Michael S., additional, Ky, Bonnie, additional, Scherrer-Crosbie, Marielle, additional, Ganame, Javier, additional, Sebag, Igal A., additional, Agler, Deborah A., additional, Badano, Luigi P., additional, Banchs, Jose, additional, Cardinale, Daniela, additional, Carver, Joseph, additional, Cerqueira, Manuel, additional, DeCara, Jeanne M., additional, Edvardsen, Thor, additional, Flamm, Scott D., additional, Force, Thomas, additional, Griffin, Brian P., additional, Jerusalem, Guy, additional, Liu, Jennifer E., additional, Magalhães, Andreia, additional, Marwick, Thomas, additional, Sanchez, Liza Y., additional, Sicari, Rosa, additional, Villarraga, Hector R., additional, and Lancellotti, Patrizio, additional

Published
2014
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32. TRANSCATHETER HEART VALVE FAILURE: A SYSTEMATIC REVIEW

Author

Mylotte, Darren, primary, Andalib, Ali, additional, Thériault-Lauzier, Pascal, additional, Dorfmeister, Magdalena, additional, Girgis, Mina, additional, Mohtashami, Sadaf, additional, Alharbi, Waleed, additional, Chetrit, Michael, additional, Galatas, Christos, additional, Mamane, Samuel, additional, Sebag, Igal, additional, Buithieu, Jean, additional, de Varennes, Benoit, additional, Lachapelle, Kevin, additional, Martucci, Joseph, additional, Lange, Ruediger, additional, and Piazza, Nicolo, additional

Published
2014
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33. Early Increases in Multiple Biomarkers Predict Subsequent Cardiotoxicity in Patients With Breast Cancer Treated With Doxorubicin, Taxanes, and Trastuzumab

Author

Ky, Bonnie, primary, Putt, Mary, additional, Sawaya, Heloisa, additional, French, Benjamin, additional, Januzzi, James L., additional, Sebag, Igal A., additional, Plana, Juan Carlos, additional, Cohen, Victor, additional, Banchs, Jose, additional, Carver, Joseph R., additional, Wiegers, Susan E., additional, Martin, Randolph P., additional, Picard, Michael H., additional, Gerszten, Robert E., additional, Halpern, Elkan F., additional, Passeri, Jonathan, additional, Kuter, Irene, additional, and Scherrer-Crosbie, Marielle, additional

Published
2014
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38. Assessment of Echocardiography and Biomarkers for the Extended Prediction of Cardiotoxicity in Patients Treated With Anthracyclines, Taxanes, and Trastuzumab

Author

Sawaya, Heloisa, primary, Sebag, Igal A., additional, Plana, Juan Carlos, additional, Januzzi, James L., additional, Ky, Bonnie, additional, Tan, Timothy C., additional, Cohen, Victor, additional, Banchs, Jose, additional, Carver, Joseph R., additional, Wiegers, Susan E., additional, Martin, Randolph P., additional, Picard, Michael H., additional, Gerszten, Robert E., additional, Halpern, Elkan F., additional, Passeri, Jonathan, additional, Kuter, Irene, additional, and Scherrer-Crosbie, Marielle, additional

Published
2012
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41. HYPERDYNAMIC LEFT VENTRICULAR FUNCTION IS ASSOCIATED WITH ADVERSE EVENTS IN ELDERLY PATIENTS UNDERGOING CARDIAC SURGERY

Author

Afilalo, Jonathan, primary, Rudski, Lawrence G., additional, Sebag, Igal A., additional, Eisenberg, Mark J., additional, Alexander, Karen P., additional, Morin, Jean-Francois, additional, Langlois, Yves, additional, Noiseux, Nicolas, additional, Perrault, Louis P., additional, Monette, Johanne, additional, Bergman, Howard, additional, and Picard, Michael H., additional

Published
2011
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43. Quantitative Assessment of Regional Myocardial Function in Mice by Tissue Doppler Imaging

Author

Sebag, Igal A., primary, Handschumacher, Mark D., additional, Ichinose, Fumito, additional, Morgan, John G., additional, Hataishi, Ryuji, additional, Rodrigues, Ana Clara T., additional, Guerrero, J. Luis, additional, Steudel, Wolfgang, additional, Raher, Michael J., additional, Halpern, Elkan F., additional, Derumeaux, Geneviève, additional, Bloch, Kenneth D., additional, Picard, Michael H., additional, and Scherrer-Crosbie, Marielle, additional

Published
2005
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44. Abstract 15683: The Inclusion of Pulmonary Arterial Pressure Confounds the Detection of Diastolic Dysfunction Using the Current American Society of Echocardiography Guidelines in Pre-Capillary Pulmonary Hypertension

Author

Telmesani, Amr, Deschamps, Jean, AlTurki, Ahmed, Benjamin, Fox, Sebag, Igal, Schlesinger, Robert, Afilalo, Jonathan, Eisenberg, Mark, Abualsaud, Ali, Langleben, David, and Rudski, Lawrence

Abstract

Background:The 2016 ASE Recommendations for the Evaluation of Left Ventricular Diastolic Function (LVDF) provides flow-diagrams to categorize patients. However, there are no dedicated criteria to assess the diastolic function in pulmonary arterial hypertension (PAH).Purpose:Because elevated PAP is fundamental to PAH, we hypothesized that the ASE diastolic function algorithm has a lower predictive value in correctly classifying diastolic function in scleroderma PAH.Methodology:We performed a single-center retrospective analysis of scleroderma patients who underwent complete echocardiography and comprehensive right and left heart catheterization for PH evaluation. PH categorization was defined using the 6thWorld Symposium hemodynamic definitions (PAH as mPAP ?20 mmHg, PCWP ?15 mmHg, PVR ? 3 WU).Results:260 patients underwent evaluation and 63 were diagnosed with PH. PAH was diagnosed in 35 (age 64 ?10, mPAP 55? 18 mmHg, LVEF 60 ? 6%) and PVH in 28 (age 65 ? 10, mPAP 34 ? 14 mmHg, LVEF 63?6%). Of the PAH patients, 20 had normal LVEDP (? 12 mmHg) and 15 increased LVEDP. In the PAH normal LVEDP patients, the ASE algorithm classified diastolic function as normal in 25%, grade 2 in 5%, Grade 3 in 5%, and ?indeterminate? in 65%. In the PAH group with increased LVEDP (> 12 mmHg), 27% were incorrectly identified as normal, 7% as grade 2 dysfunction, and 66% as indeterminate. The diastolic function algorithm has a sensitivity of 27% and specificity of 75% to diagnose a LVEDP ? 12 mmHg, with an AUC of 0.508 (p=0.91). With exclusion of sPAP from the algorithm, indeterminate cases in both PAH groups were reclassified as normal, resulting in improved sensitivity (93%) but poorer specificity (10%), and a similar AUC (0.517, p=0.72). In PVH patients, the algorithm performed better with a sensitivity of 63% and specificity of 83% to predict LVEDP > 12 mmHg with AUC 0.773, p=0.017.Conclusion:In scleroderma patients with PAH, the ASE diastolic algorithm performs poorly and is confounded by including PAP as a parameter. The sensitivity of the algorithm is improved by the exclusion of sPAP although with reduced specificity. It remains inadequate to reliably diagnose normal LVEDP. Algorithm modifications including exclusion of PAP, must be employed in suspected scleroderma PAH.

Published
2019
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45. Abstract 12799: Changes in Plasma Hemopexin Are Inversely Associated With Myocardial Strain in Breast Cancer Patients Treated With Anthracyclines

Author

Asnani, Aarti, Ngo, Debby, Yang, Qiong, Benson, Mark, Sinha, Sumita, Shen, Dongxiao, Sebag, Igal, Plana, Juan C, Scherrer-Crosbie, Marielle, and Gerszten, Robert E

Abstract

Introduction:Anthracyclines are commonly used for the treatment of breast cancer, but they cause cardiotoxicity in 10% of all patients. We hypothesized that changes in circulating plasma proteins shortly after the completion of anthracyclines are associated with the development of cardiotoxicity.Methods:We used an aptamer-based proteomic platform to measure 1317 proteins in plasma samples obtained from 30 breast cancer patients. Proteins were measured at baseline and at 3 months, following completion of anthracyclines. In a subset of patients (n = 12), proteins were measured at 6 months, during treatment with trastuzumab. Protein levels were log-normalized, and the change in protein level at 3 or 6 months was compared to the change in global longitudinal strain (GLS) at 3 months for each patient using Pearson?s correlation coefficient.Results:Across the cohort, GLS decreased by a median of 16.4% (absolute value) at 3 months. Six patients developed clinical congestive heart failure during the course of the study. Change in GLS was inversely associated with the change in hemopexin at 3 months (r = -0.59, p = 0.0005, FDR q = 0.2) and at 6 months (r = -0.52, p = 0.09). Of the five patients with the greatest increase in hemopexin, three developed congestive heart failure. We also observed changes in plasma proteins that have been previously reported in the setting of anthracycline cardiotoxicity, including neuregulin-1 (r = 0.44, p = 0.01 at 3 months), glutathione S-transferase (r = - 0.4, p = 0.02 at 3 months), interleukin receptor 1 antagonist (r = -0.72, p = 0.009 at 6 months), and myosin binding protein C (r = 0.59, p = 0.04).Conclusions:In this initial discovery cohort, increased levels of hemopexin, a circulating heme-binding protein, were associated with decreased myocardial strain in patients treated for breast cancer. Iron-mediated oxidative stress has been proposed to contribute to anthracycline cardiotoxicity, and increased hemopexin levels may serve as an early marker of cardiotoxicity. Studies are ongoing to validate these findings using complementary techniques in other patient populations.

Published
2019
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46. Expert consensus for multi-modality imaging evaluation of cardiovascular complications of radiotherapy in adults: a report from the European Association of Cardiovascular Imaging and the American Society of Echocardiography

Author

Luigi P. Badano, Jan Bogaert, Ronald G. Schwartz, Steven C. Port, Marielle Scherrer-Crosbie, Maurizio Galderisi, Samuel Wann, Philippe Coucke, Brian P. Griffin, Jutta Bergler, Vuyisile T. Nkomo, Juan Carlos Plana, Phillip C. Yang, Patrizio Lancellotti, Laurent Davin, Paul A. Heidenreich, Thor Edvardsen, Jens-Uwe Voigt, Raluca Elena Dulgheru, Oliver Gaemperli, Igal A. Sebag, Koen Nieman, Bernard Cosyns, University of Zurich, Lancellotti, Patrizio, Nkomo, Vuyisile T., Badano, Luigi P., Bergler, Jutta, Bogaert, Jan, Davin, Laurent, Cosyns, Bernard, Coucke, Philippe, Dulgheru, Raluca, Edvardsen, Thor, Gaemperli, Oliver, Galderisi, Maurizio, Griffin, Brian, Heidenreich, Paul A., Nieman, Koen, Plana, Juan C., Port, Steven C., Scherrer Crosbie, Marielle, Schwartz, Ronald G., Sebag, Igal A., Voigt, Jens Uwe, Wann, Samuel, Yang, Phillip C., Radiology & Nuclear Medicine, Nkomo, Vuyisile T, Badano, Luigi P, Bergler Klein, Jutta, Heidenreich, Paul A, Plana, Juan C, Port, Steven C, Schwartz, Ronald G, and Sebag, Igal A

Subjects
Cardiac magnetic resonance, Heart disease, medicine.medical_treatment, Multimodal Imaging, Coronary artery disease, Cardiovascular Disease, Nuclear Medicine and Imaging, Neoplasms, Radiation Injurie, Adjuvant, Cardiac imaging, Radiation, medicine.diagnostic_test, Heart, General Medicine, Middle Aged, Europe, Cardiovascular Diseases, Echocardiography, 10209 Clinic for Cardiology, Radiology, Cardiology and Cardiovascular Medicine, Human, Cardiac computed tomography, Nuclear cardiology, Radiotherapy, Adult, Dose-Response Relationship, Radiation, Humans, Radiation Injuries, Radiotherapy, Adjuvant, Risk, Radiology, Nuclear Medicine and Imaging, medicine.medical_specialty, Consensus, Consensu, 610 Medicine & health, 2705 Cardiology and Cardiovascular Medicine, Dose-Response Relationship, SDG 3 - Good Health and Well-being, medicine, Medical imaging, 2741 Radiology, Nuclear Medicine and Imaging, Radiology, Nuclear Medicine and imaging, Intensive care medicine, Cardiotoxicity, cardiac computed tomography, cardiac magnetic resonance, echocardiography, heart disease, nuclear cardiology, radiotherapy, United States, business.industry, Cancer, Magnetic resonance imaging, medicine.disease, Radiation therapy, Neoplasm, business
Abstract

Cardiac toxicity is one of the most concerning side effects of anti-cancer therapy. The gain in life expectancy obtained with anti-cancer therapy can be compromised by increased morbidity and mortality associated with its cardiac complications. While radiosensitivity of the heart was initially recognized only in the early 1970s, the heart is regarded in the current era as one of the most critical dose-limiting organs in radiotherapy. Several clinical studies have identified adverse clinical consequences of radiation-induced heart disease (RIHD) on the outcome of long-term cancer survivors. A comprehensive review of potential cardiac complications related to radiotherapy is warranted. An evidence-based review of several imaging approaches used to detect, evaluate, and monitor RIHD is discussed. Recommendations for the early identification and monitoring of cardiovascular complications of radiotherapy by cardiac imaging are also proposed.

Published
2013

47. Expert consensus for multimodality imaging evaluation of adult patients during and after cancer therapy: a report from the American Society of Echocardiography and the European Association of Cardiovascular Imaging

Author

Jeanne M. DeCara, Thomas H. Marwick, Guy Jerusalem, Liza Y. Sanchez, Jose Banchs, Scott D. Flamm, Brian P. Griffin, Jennifer E. Liu, Joseph R. Carver, Manuel D. Cerqueira, Michael S. Ewer, Daniela Cardinale, Bonnie Ky, Juan Carlos Plana, Andreia Magalhaes, Ana Barac, Marielle Scherrer-Crosbie, Luigi P. Badano, Thor Edvardsen, Thomas Force, Patrizio Lancellotti, Javier Ganame, Hector R. Villarraga, Rosa Sicari, Maurizio Galderisi, Deborah A. Agler, Igal A. Sebag, Plana, J, Galderisi, M, Barac, A, Ewer, M, Ky, B, Scherrer-Crosbie, M, Ganame, J, Sebag, I, Agler, D, Badano, L, Banchs, J, Cardinale, D, Carver, J, Cerqueira, M, Decara, J, Edvardsen, T, Flamm, S, Force, T, Griffin, B, Jerusalem, G, Liu, J, Magalhaes, A, Marwick, T, Sanchez, L, Sicari, R, Villarraga, H, Lancellotti, P, Plana, Juan Carlo, Galderisi, Maurizio, Barac, Ana, Ewer, Michael S., Ky, Bonnie, Scherrer Crosbie, Marielle, Ganame, Javier, Sebag, Igal A., Agler, Deborah A., Badano, Luigi P., Banchs, Jose, Cardinale, Daniela, Carver, Joseph, Cerqueira, Manuel, Decara, Jeanne M., Edvardsen, Thor, Flamm, Scott D., Force, Thoma, Griffin, Brian P., Jerusalem, Guy, Liu, Jennifer E., Magalhães, Andreia, Marwick, Thoma, Sanchez, Liza Y., Sicari, Rosa, Villarraga, Hector R., and Lancellotti, Patrizio

Subjects
Male, Left, Speckle tracking echocardiography, Medical Oncology, Multimodal Imaging, Strain, Coronary artery disease, Antineoplastic Agent, Ventricular Dysfunction, Left, Nuclear Medicine and Imaging, Neoplasms, Ventricular Dysfunction, Cardiac imaging, Societies, Medical, Left ventricular dysfunction, Ejection fraction, Early detection, General Medicine, Chemoradiotherapy, Europe, Heart Disease, Practice Guidelines as Topic, Cardiology, Female, Position Paper, Radiology, Cardiology and Cardiovascular Medicine, Human, Cardiac function curve, Biomarkers, Chemotherapy, Doxorubicin, Three-dimensional echocardiography, Trastuzumab, Adult, Humans, United States, Radiology, Nuclear Medicine and Imaging, United State, medicine.medical_specialty, Consensus, Heart Diseases, Diastole, Consensu, Antineoplastic Agents, Internal medicine, Medical, medicine, Radiology, Nuclear Medicine and imaging, Systole, Cardiotoxicity, business.industry, Gold standard, Cancer, Cardiac reserve, Biomarker, MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, medicine.disease, Heart failure, Neoplasm, business, Societies
Abstract

A. Definition, classification, and mechanisms of toxicity Cardiac dysfunction resulting from exposure to cancer therapeutics was first recognized in the 1960s, with the widespread introduction of anthracyclines into the oncological therapeutic armamentarium.1 Heart failure (HF) associated with anthracyclines was then recognized as an important side effect. As a result, physicians learned to limit their doses to avoid cardiac dysfunction.2 Several strategies have been used over the past decades to detect it. Two of them evolved over time to be very useful: endomyocardial biopsies and monitoring of left ventricular (LV) ejection fraction (LVEF) by cardiac imaging. Examination of endomyocardial biopsies proved to be the most sensitive and specific parameter for the identification of anthracycline-induced LV dysfunction and became the gold standard in the 1970s. However, the interest in endomyocardial biopsy has diminished over time because of the reduction in the cumulative dosages used to treat malignancies, the invasive nature of the procedure, and the remarkable progress made in non-invasive cardiac imaging. The non-invasive evaluation of LVEF has gained importance, and notwithstanding the limitations of the techniques used for its calculation, has emerged as the most widely used strategy for monitoring the changes in cardiac function, both during and after the administration of potentially cardiotoxic cancer treatment.3–5 The timing of LV dysfunction can vary among agents. In the case of anthracyclines, the damage occurs immediately after the exposure;6 for others, the time frame between drug administration and detectable cardiac dysfunction appears to be more variable. Nevertheless, the heart has significant cardiac reserve, and the expression of damage in the form of alterations in systolic or diastolic parameters may not be overt until a substantial amount of cardiac reserve has been exhausted. Thus, cardiac damage may not become apparent until years or even decades after receiving the cardiotoxic treatment. This is particularly applicable to …

Published
2014

48. Expert consensus for multimodality imaging evaluation of adult patients during and after cancer therapy: a report from the American Society of Echocardiography and the European Association of Cardiovascular Imaging.

Author

Plana JC, Galderisi M, Barac A, Ewer MS, Ky B, Scherrer-Crosbie M, Ganame J, Sebag IA, Agler DA, Badano LP, Banchs J, Cardinale D, Carver J, Cerqueira M, DeCara JM, Edvardsen T, Flamm SD, Force T, Griffin BP, Jerusalem G, Liu JE, Magalhães A, Marwick T, Sanchez LY, Sicari R, Villarraga HR, and Lancellotti P

Subjects
Adult, Biomarkers analysis, Cardiology standards, Consensus, Female, Humans, Male, Medical Oncology standards, Practice Guidelines as Topic, Societies, Medical, United States, Antineoplastic Agents adverse effects, Heart Diseases chemically induced, Heart Diseases diagnosis, Multimodal Imaging standards, Neoplasms drug therapy
Published
2014
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49. Cardiac response to doxorubicin and dexrazoxane in intact and ovariectomized young female rats at rest and after swim training.

Author

Calvé A, Haddad R, Barama SN, Meilleur M, Sebag IA, and Chalifour LE

Subjects
Animals, Calcium metabolism, Calsequestrin metabolism, Echocardiography, Female, Heart physiology, Models, Animal, Myocardium metabolism, Rats, Rats, Sprague-Dawley, Sarcoplasmic Reticulum Calcium-Transporting ATPases metabolism, Antineoplastic Agents pharmacology, Doxorubicin pharmacology, Heart drug effects, Ovariectomy, Razoxane pharmacology, Rest physiology, Swimming physiology
Abstract

The impact of cancer therapies on adult cardiac function is becoming a concern as more children survive their initial cancer. Cardiovascular disease is now a significant problem to adult survivors of childhood cancer. Specifically, doxorubicin (DOX) may be particularly harmful in young girls. The objective of this study was to characterize DOX damage and determine the ability of dexrazoxane (DEX) to reduce DOX-mediated cardiac damage in sedentary and swim-trained female rats. Female Sprague-Dawley rats were left intact or ovariectomized (OVX) at weaning then injected with DEX (60 mg/kg) before DOX (3 mg/kg), DOX alone, or PBS. Rats were separated into sedentary and swim cohorts. Body weight was reduced in DOX:DEX- but not PBS- or DOX-treated rats. Echocardiographic parameters were similar in sedentary rats. Swim training revealed greater concentric remodeling in DOX-treated rats and reduced fractional shortening in DOX:DEX-treated rats. Calsequestrin 2 was reduced with DOX and increased with DOX:DEX postswim. Sarco(endo)plasmic reticulum Ca(2+)-ATPase 2a was reduced and calsequestrin 2 reduced further by swim training only in intact rats. OVX rats were heavier and developed eccentric remodeling post-swim with DOX and eccentric hypertrophy with DOX:DEX. Changes in SERCA2a and calsequestrin 2 expression were not observed. Ovariectomized DOX- and DOX:DEX-treated rats stopped growing during swim training. DEX coinjection did not relieve DOX-mediated cardiotoxicity in intact or hormone-deficient rats. DOX-mediated reductions in growth, cardiac function, and expression of calcium homeostasis proteins were exacerbated by swim. DEX coadministration did not substantially relieve DOX-mediated cardiotoxicity in young female rats. Ovarian hormones reduce DOX-induced cardiotoxicity.

Published
2012
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50. Sex hormone control of left ventricular structure/function: mechanistic insights using echocardiography, expression, and DNA methylation analyses in adult mice.

Author

Sebag IA, Gillis MA, Calderone A, Kasneci A, Meilleur M, Haddad R, Noiles W, Patel B, and Chalifour LE

Subjects
Animals, Base Sequence, Calcium physiology, Calsequestrin genetics, Calsequestrin physiology, Cell Line, DNA Methylation, Echocardiography, Estrogen Receptor beta genetics, Estrogen Receptor beta physiology, Female, Gene Expression Regulation, Gonadal Steroid Hormones biosynthesis, Gonadal Steroid Hormones genetics, Homeostasis physiology, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Molecular Sequence Data, Myocardium cytology, Orchiectomy, Ovariectomy, Sodium-Calcium Exchanger genetics, Gonadal Steroid Hormones physiology, Ventricular Function, Left physiology
Abstract

Calcium flux into and out of the sarco(endo)plasmic reticulum is vitally important to cardiac function because the cycle of calcium entry and exit controls contraction and relaxation. Putative estrogen and androgen consensus binding sites near to a CpG island are present in the cardiac calsequestrin 2 (CSQ2) promoter. Cardiomyocytes express sex hormone receptors and respond to sex hormones. We hypothesized that sex hormones control CSQ2 expression in cardiomyocytes and so affect cardiac structure/function. Echocardiographic analysis of male and female C57bl6n mice identified thinner walled and lighter hearts in females and significant concentric remodeling after long-term gonadectomy. CSQ2 and sodium-calcium exchanger-1 (NCX1) expression was significantly increased in female compared with male hearts and decreased postovariectomy. NCX1, but not CSQ2, expression was increased postcastration. CSQ2 expression was reduced when H9c2 cells were cultured in hormone-deficient media; increased when estrogen receptor-α (ERα), estrogen receptor-β (ERβ), or androgen agonists were added; and increased in hearts from ERβ-deficient mice. CSQ2 expression was reduced in mice fed a diet low in the methyl donor folic acid and in cells treated with 5-azadeoxycytidine suggesting an involvement of DNA methylation. DNA methylation in CpG in the CSQ2 CpG island was significantly different in males and females and was additionally changed postgonadectomy. Expression of DNA methyltransferases 1, 3a, and 3b was unchanged. These studies strongly link sex hormone-directed changes in CSQ2 expression to DNA methylation with changed expression correlated with altered left ventricular structure and function.

Published
2011
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