Search

Your search keyword '"Seagroves, Tiffany N."' showing total 241 results
Start Over Author "Seagroves, Tiffany N."
241 results on '"Seagroves, Tiffany N."'

2. Biological activity of a stable 6-aryl-2-benzoyl-pyridine colchicine-binding site inhibitor, 60c, in metastatic, triple-negative breast cancer

Author

Oluwalana, Damilola, primary, Adeleye, Kelli L, additional, Krutilina, Raisa I, additional, Chen, Hao, additional, Playa, Hilaire, additional, Deng, Shanshan, additional, Parke, Deanna N, additional, Abernathy, John, additional, Middleton, Leona, additional, Cullom, Alexandra, additional, Thalluri, Bhargavi, additional, Ma, Dejian, additional, Meibohm, Bernd, additional, Miller, Duane D, additional, Seagroves, Tiffany N, additional, and Li, Wei, additional

Published
2024
Full Text
View/download PDF

3. The WNT10B network is associated with survival and metastases in chemoresistant triple-negative breast cancer

Author

El Ayachi, Ikbale, Fatima, Iram, Wend, Peter, Alva-Ornelas, Jackelyn A, Runke, Stephanie, Kuenzinger, William L, Silva, Julio, Silva, Wendy, Gray, Joseph K, Lehr, Stephan, Barch, Hilaire C, Krutilina, Raisa I, White, Andrew C, Cardiff, Robert, Yee, Lisa D, Yang, Lily, O'Regan, Ruth M, Lowry, William E, Seagroves, Tiffany N, Seewaldt, Victoria, Krum, Susan A, and Miranda-Carboni, Gustavo A

Subjects
Cancer, Breast Cancer, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Acetylation, Alleles, Animals, Antineoplastic Combined Chemotherapy Protocols, Biomarkers, Tumor, Bridged Bicyclo Compounds, Heterocyclic, Cell Line, Tumor, Doxorubicin, Drug Resistance, Neoplasm, Drug Synergism, Enhancer of Zeste Homolog 2 Protein, Female, HMGA2 Protein, Humans, Lymphoid Enhancer-Binding Factor 1, Mice, Mice, Transgenic, Middle Aged, Neoplasm Metastasis, Proto-Oncogene Proteins, Pyrimidinones, Survival Rate, Transcription Factor 4, Triple Negative Breast Neoplasms, Wnt Proteins, beta Catenin, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

Triple-negative breast cancer (TNBC) commonly develops resistance to chemotherapy, yet markers predictive of chemoresistance in this disease are lacking. Here, we define WNT10B-dependent biomarkers for β-CATENIN/HMGA2/EZH2 signaling predictive of reduced relapse-free survival. Concordant expression of HMGA2 and EZH2 proteins is observed in MMTV-Wnt10bLacZ transgenic mice during metastasis, and Hmga2 haploinsufficiency decreased EZH2 protein expression, repressing lung metastasis. A novel autoregulatory loop interdependent on HMGA2 and EZH2 expression is essential for β-CATENIN/TCF-4/LEF-1 transcription. Mechanistically, both HMGA2 and EZH2 displaced Groucho/TLE1 from TCF-4 and served as gatekeepers for K49 acetylation on β-CATENIN, which is essential for transcription. In addition, we discovered that HMGA2-EZH2 interacts with the PRC2 complex. Absence of HMGA2 or EZH2 expression or chemical inhibition of Wnt signaling in a chemoresistant patient-derived xenograft (PDX) model of TNBC abolished visceral metastasis, repressing AXIN2, MYC, EZH2, and HMGA2 expression in vivo. Combinatorial therapy of a WNT inhibitor with doxorubicin synergistically activated apoptosis in vitro, resensitized PDX-derived cells to doxorubicin, and repressed lung metastasis in vivo. We propose that targeting the WNT10B biomarker network will provide improved outcomes for TNBC. SIGNIFICANCE: These findings reveal targeting the WNT signaling pathway as a potential therapeutic strategy in triple-negative breast cancer.Graphical Abstract: http://cancerres.aacrjournals.org/content/canres/79/5/982/F1.large.jpg.

Published
2019

7. Data from Taxol Induces Brk-dependent Prosurvival Phenotypes in TNBC Cells through an AhR/GR/HIF–driven Signaling Axis

Author

Regan Anderson, Tarah M., primary, Ma, Shihong, primary, Perez Kerkvliet, Carlos, primary, Peng, Yan, primary, Helle, Taylor M., primary, Krutilina, Raisa I., primary, Raj, Ganesh V., primary, Cidlowski, John A., primary, Ostrander, Julie H., primary, Schwertfeger, Kathryn L., primary, Seagroves, Tiffany N., primary, and Lange, Carol A., primary

Published
2023
Full Text
View/download PDF

10. Supplementary figure legends from Taxol Induces Brk-dependent Prosurvival Phenotypes in TNBC Cells through an AhR/GR/HIF–driven Signaling Axis

Author

Regan Anderson, Tarah M., primary, Ma, Shihong, primary, Perez Kerkvliet, Carlos, primary, Peng, Yan, primary, Helle, Taylor M., primary, Krutilina, Raisa I., primary, Raj, Ganesh V., primary, Cidlowski, John A., primary, Ostrander, Julie H., primary, Schwertfeger, Kathryn L., primary, Seagroves, Tiffany N., primary, and Lange, Carol A., primary

Published
2023
Full Text
View/download PDF

12. Data from Breast Tumor Kinase (Brk/PTK6) Mediates Advanced Cancer Phenotypes via SH2-Domain Dependent Activation of RhoA and Aryl Hydrocarbon Receptor (AhR) Signaling

Author

Dwyer, Amy R., primary, Kerkvliet, Carlos Perez, primary, Krutilina, Raisa I., primary, Playa, Hilaire C., primary, Parke, Deanna N., primary, Thomas, Warner A., primary, Smeester, Branden A., primary, Moriarity, Branden S., primary, Seagroves, Tiffany N., primary, and Lange, Carol A., primary

Published
2023
Full Text
View/download PDF

14. Supplemental Methods including references, Supplemental Table 1, and Supplemental Figures 1-5 from Breast Tumor Kinase (Brk/PTK6) Mediates Advanced Cancer Phenotypes via SH2-Domain Dependent Activation of RhoA and Aryl Hydrocarbon Receptor (AhR) Signaling

Author

Dwyer, Amy R., primary, Kerkvliet, Carlos Perez, primary, Krutilina, Raisa I., primary, Playa, Hilaire C., primary, Parke, Deanna N., primary, Thomas, Warner A., primary, Smeester, Branden A., primary, Moriarity, Branden S., primary, Seagroves, Tiffany N., primary, and Lange, Carol A., primary

Published
2023
Full Text
View/download PDF

17. Supplementary Data from Colchicine-Binding Site Agent CH-2-77 as a Potent Tubulin Inhibitor Suppressing Triple-Negative Breast Cancer

Author

Deng, Shanshan, primary, Krutilina, Raisa I., primary, Hartman, Kelli L., primary, Chen, Hao, primary, Parke, Deanna N., primary, Wang, Rui, primary, Mahmud, Foyez, primary, Ma, Dejian, primary, Lukka, Pradeep B., primary, Meibohm, Bernd, primary, Seagroves, Tiffany N., primary, Miller, Duane D., primary, and Li, Wei, primary

Published
2023
Full Text
View/download PDF

18. Data from Colchicine-Binding Site Agent CH-2-77 as a Potent Tubulin Inhibitor Suppressing Triple-Negative Breast Cancer

Author

Deng, Shanshan, primary, Krutilina, Raisa I., primary, Hartman, Kelli L., primary, Chen, Hao, primary, Parke, Deanna N., primary, Wang, Rui, primary, Mahmud, Foyez, primary, Ma, Dejian, primary, Lukka, Pradeep B., primary, Meibohm, Bernd, primary, Seagroves, Tiffany N., primary, Miller, Duane D., primary, and Li, Wei, primary

Published
2023
Full Text
View/download PDF

19. Supplementary Figure 3 from Taxol Induces Brk-dependent Prosurvival Phenotypes in TNBC Cells through an AhR/GR/HIF–driven Signaling Axis

Author

Regan Anderson, Tarah M., primary, Ma, Shihong, primary, Perez Kerkvliet, Carlos, primary, Peng, Yan, primary, Helle, Taylor M., primary, Krutilina, Raisa I., primary, Raj, Ganesh V., primary, Cidlowski, John A., primary, Ostrander, Julie H., primary, Schwertfeger, Kathryn L., primary, Seagroves, Tiffany N., primary, and Lange, Carol A., primary

Published
2023
Full Text
View/download PDF

20. Supplementary Figure 4 from Taxol Induces Brk-dependent Prosurvival Phenotypes in TNBC Cells through an AhR/GR/HIF–driven Signaling Axis

Author

Regan Anderson, Tarah M., primary, Ma, Shihong, primary, Perez Kerkvliet, Carlos, primary, Peng, Yan, primary, Helle, Taylor M., primary, Krutilina, Raisa I., primary, Raj, Ganesh V., primary, Cidlowski, John A., primary, Ostrander, Julie H., primary, Schwertfeger, Kathryn L., primary, Seagroves, Tiffany N., primary, and Lange, Carol A., primary

Published
2023
Full Text
View/download PDF

21. Supplementary Figure 5 from Taxol Induces Brk-dependent Prosurvival Phenotypes in TNBC Cells through an AhR/GR/HIF–driven Signaling Axis

Author

Regan Anderson, Tarah M., primary, Ma, Shihong, primary, Perez Kerkvliet, Carlos, primary, Peng, Yan, primary, Helle, Taylor M., primary, Krutilina, Raisa I., primary, Raj, Ganesh V., primary, Cidlowski, John A., primary, Ostrander, Julie H., primary, Schwertfeger, Kathryn L., primary, Seagroves, Tiffany N., primary, and Lange, Carol A., primary

Published
2023
Full Text
View/download PDF

23. Supplementary Figure 1 from Taxol Induces Brk-dependent Prosurvival Phenotypes in TNBC Cells through an AhR/GR/HIF–driven Signaling Axis

Author

Regan Anderson, Tarah M., primary, Ma, Shihong, primary, Perez Kerkvliet, Carlos, primary, Peng, Yan, primary, Helle, Taylor M., primary, Krutilina, Raisa I., primary, Raj, Ganesh V., primary, Cidlowski, John A., primary, Ostrander, Julie H., primary, Schwertfeger, Kathryn L., primary, Seagroves, Tiffany N., primary, and Lange, Carol A., primary

Published
2023
Full Text
View/download PDF

26. Supplementary Figure 2 from Taxol Induces Brk-dependent Prosurvival Phenotypes in TNBC Cells through an AhR/GR/HIF–driven Signaling Axis

Author

Regan Anderson, Tarah M., primary, Ma, Shihong, primary, Perez Kerkvliet, Carlos, primary, Peng, Yan, primary, Helle, Taylor M., primary, Krutilina, Raisa I., primary, Raj, Ganesh V., primary, Cidlowski, John A., primary, Ostrander, Julie H., primary, Schwertfeger, Kathryn L., primary, Seagroves, Tiffany N., primary, and Lange, Carol A., primary

Published
2023
Full Text
View/download PDF

27. Supplementary Figure 6 from Taxol Induces Brk-dependent Prosurvival Phenotypes in TNBC Cells through an AhR/GR/HIF–driven Signaling Axis

Author

Regan Anderson, Tarah M., primary, Ma, Shihong, primary, Perez Kerkvliet, Carlos, primary, Peng, Yan, primary, Helle, Taylor M., primary, Krutilina, Raisa I., primary, Raj, Ganesh V., primary, Cidlowski, John A., primary, Ostrander, Julie H., primary, Schwertfeger, Kathryn L., primary, Seagroves, Tiffany N., primary, and Lange, Carol A., primary

Published
2023
Full Text
View/download PDF

28. Supplementary Data from The WNT10B Network Is Associated with Survival and Metastases in Chemoresistant Triple-Negative Breast Cancer

Author

El Ayachi, Ikbale, primary, Fatima, Iram, primary, Wend, Peter, primary, Alva-Ornelas, Jackelyn A., primary, Runke, Stephanie, primary, Kuenzinger, William L., primary, Silva, Julio, primary, Silva, Wendy, primary, Gray, Joseph K., primary, Lehr, Stephan, primary, Barch, Hilaire C., primary, Krutilina, Raisa I., primary, White, Andrew C., primary, Cardiff, Robert, primary, Yee, Lisa D., primary, Yang, Lily, primary, O'Regan, Ruth M., primary, Lowry, William E., primary, Seagroves, Tiffany N., primary, Seewaldt, Victoria, primary, Krum, Susan A., primary, and Miranda-Carboni, Gustavo A., primary

Published
2023
Full Text
View/download PDF

30. Data from The WNT10B Network Is Associated with Survival and Metastases in Chemoresistant Triple-Negative Breast Cancer

Author

El Ayachi, Ikbale, primary, Fatima, Iram, primary, Wend, Peter, primary, Alva-Ornelas, Jackelyn A., primary, Runke, Stephanie, primary, Kuenzinger, William L., primary, Silva, Julio, primary, Silva, Wendy, primary, Gray, Joseph K., primary, Lehr, Stephan, primary, Barch, Hilaire C., primary, Krutilina, Raisa I., primary, White, Andrew C., primary, Cardiff, Robert, primary, Yee, Lisa D., primary, Yang, Lily, primary, O'Regan, Ruth M., primary, Lowry, William E., primary, Seagroves, Tiffany N., primary, Seewaldt, Victoria, primary, Krum, Susan A., primary, and Miranda-Carboni, Gustavo A., primary

Published
2023
Full Text
View/download PDF

32. Supplementary Figure 2 from Breast Tumor Kinase (Brk/PTK6) Is a Mediator of Hypoxia-Associated Breast Cancer Progression

Author

Regan Anderson, Tarah M., primary, Peacock, Danielle L., primary, Daniel, Andrea R., primary, Hubbard, Gregory K., primary, Lofgren, Kristopher A., primary, Girard, Brian J., primary, Schörg, Alexandra, primary, Hoogewijs, David, primary, Wenger, Roland H., primary, Seagroves, Tiffany N., primary, and Lange, Carol A., primary

Published
2023
Full Text
View/download PDF

35. Supplementary Table from Breast Tumor Kinase (Brk/PTK6) Is a Mediator of Hypoxia-Associated Breast Cancer Progression

Author

Regan Anderson, Tarah M., primary, Peacock, Danielle L., primary, Daniel, Andrea R., primary, Hubbard, Gregory K., primary, Lofgren, Kristopher A., primary, Girard, Brian J., primary, Schörg, Alexandra, primary, Hoogewijs, David, primary, Wenger, Roland H., primary, Seagroves, Tiffany N., primary, and Lange, Carol A., primary

Published
2023
Full Text
View/download PDF

38. Supplementary Figure 1 from Breast Tumor Kinase (Brk/PTK6) Is a Mediator of Hypoxia-Associated Breast Cancer Progression

Author

Regan Anderson, Tarah M., primary, Peacock, Danielle L., primary, Daniel, Andrea R., primary, Hubbard, Gregory K., primary, Lofgren, Kristopher A., primary, Girard, Brian J., primary, Schörg, Alexandra, primary, Hoogewijs, David, primary, Wenger, Roland H., primary, Seagroves, Tiffany N., primary, and Lange, Carol A., primary

Published
2023
Full Text
View/download PDF

40. Supplementary Figure 3 from Breast Tumor Kinase (Brk/PTK6) Is a Mediator of Hypoxia-Associated Breast Cancer Progression

Author

Regan Anderson, Tarah M., primary, Peacock, Danielle L., primary, Daniel, Andrea R., primary, Hubbard, Gregory K., primary, Lofgren, Kristopher A., primary, Girard, Brian J., primary, Schörg, Alexandra, primary, Hoogewijs, David, primary, Wenger, Roland H., primary, Seagroves, Tiffany N., primary, and Lange, Carol A., primary

Published
2023
Full Text
View/download PDF

42. Supplementary Methods from Breast Tumor Kinase (Brk/PTK6) Is a Mediator of Hypoxia-Associated Breast Cancer Progression

Author

Regan Anderson, Tarah M., primary, Peacock, Danielle L., primary, Daniel, Andrea R., primary, Hubbard, Gregory K., primary, Lofgren, Kristopher A., primary, Girard, Brian J., primary, Schörg, Alexandra, primary, Hoogewijs, David, primary, Wenger, Roland H., primary, Seagroves, Tiffany N., primary, and Lange, Carol A., primary

Published
2023
Full Text
View/download PDF

43. Connect, Collaborate, and Succeed: The Ninth Annual Meeting of the Southeastern Association of Shared Resources (SEASR) Nashville, TN, USA, June 8–10, 2022

Author

Bagchi, Pritha, primary, Boukli, Nawal M., additional, Browner, Natasha, additional, Daria, Deidre, additional, Griffiths, Lyra, additional, Mesa, Tania E., additional, Phipps, John, additional, Pitre, Aaron, additional, Schafer, Jenny, additional, Somasundaram, Thayumanasamy, additional, and Seagroves, Tiffany N., additional

Published
2023
Full Text
View/download PDF

50. Colchicine-Binding Site Agent CH-2-77 as a Potent Tubulin Inhibitor Suppressing Triple-Negative Breast Cancer

Author

Deng, Shanshan, primary, Krutilina, Raisa I., additional, Hartman, Kelli L., additional, Chen, Hao, additional, Parke, Deanna N., additional, Wang, Rui, additional, Mahmud, Foyez, additional, Ma, Dejian, additional, Lukka, Pradeep B., additional, Meibohm, Bernd, additional, Seagroves, Tiffany N., additional, Miller, Duane D., additional, and Li, Wei, additional

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results