1. Aquaporin-4 Expression Patterns in Glioblastoma Pre-Chemoradiation and at Time of Suspected Progression
- Author
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Hwa Huang, Susannah G. Ellsworth, Stuart A. Grossman, Scott Barletta, Fausto J. Rodriguez, Michael J. Levy, Omar Dzaye, and Matthias Holdhoff
- Subjects
Adult ,Male ,0301 basic medicine ,Cancer Research ,Disease status ,Pathology ,medicine.medical_specialty ,Biopsy ,03 medical and health sciences ,0302 clinical medicine ,Edema ,medicine ,Humans ,Aged ,Retrospective Studies ,Aquaporin 4 ,Repeat biopsy ,Brain Neoplasms ,business.industry ,Repeat resection ,Chemoradiotherapy ,Glioma ,General Medicine ,Middle Aged ,medicine.disease ,Staining ,Gene Expression Regulation, Neoplastic ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,Disease Progression ,Immunohistochemistry ,Female ,sense organs ,Neoplasm Recurrence, Local ,medicine.symptom ,Glioblastoma ,business - Abstract
There has been controversy about the presence and potential role of aquaporin-4 (AQP4) in glioblastoma (GBM). We analyzed tissue from 22 patients with newly-diagnosed GBM as well as matching tissue from 17 of these cases who underwent repeat resection for suspected recurrence and performed immunohistochemical analysis for AQP-4 expression. While some degree of AQP4 expression was detected in all 22 cases (39 samples), there was no clear relationship between staining pattern and disease status (active versus inactive GBM) between baseline and time of repeat biopsy. In addition, there was no clear relationship between AQP4 expression and degree of edema.
- Published
- 2019
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