157 results on '"Scott, Clay W."'
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2. Human Stem Cell-Derived Cardiomyocytes in Cellular Impedance Assays: Bringing Cardiotoxicity Screening to the Front Line
3. Biochemical characterization and in vitro activity of AZ513, a noncovalent, reversible, and noncompetitive inhibitor of fatty acid amide hydrolase
4. A microfluidic system that replicates pharmacokinetic (PK) profiles in vitro improves prediction of in vivo efficacy in preclinical models
5. Label-free whole-cell assays: expanding the scope of GPCR screening
6. Evaluating Cellular Impedance Assays for Detection of GPCR Pleiotropic Signaling and Functional Selectivity
7. Insulin Stimulates the Generation of an Adipocyte Phosphoprotein That is Isolated with a Monoclonal Antibody against the Regulatory Subunit of Bovine Heart cAMP-Dependent Protein Kinase
8. Human ileal organoid model recapitulates clinical incidence of diarrhea associated with small molecule drugs
9. An Impedance-Based Cellular Assay Using Human iPSC-Derived Cardiomyocytes to Quantify Modulators of Cardiac Contractility
10. Evaluation of cellular dielectric spectroscopy, a whole-cell, label-free technology for drug discovery on [G.sub.i]-coupled GPCRs
11. Cellular Impedance Assays for Predictive Preclinical Drug Screening of Kinase Inhibitor Cardiovascular Toxicity
12. A Homogeneous in Vitro Functional Assay for Estrogen Receptors: Coactivator Recruitment
13. Parkin suppresses wild-type [formula omitted]-synuclein-induced toxicity in SHSY-5Y cells
14. Developingin vitroassays to transform gastrointestinal safety assessment: potential for microphysiological systems
15. Microplate gel-filtration method for radioligand-binding assays
16. C3 activation is inhibited by analogs of compstatin but not by serine protease inhibitors or peptidyl α-ketoheterocycles
17. MOLECULAR CLONING OF THE GUINEA-PIG IL-5 RECEPTOR α AND β SUBUNITS AND RECONSTITUTION OF A HIGH AFFINITY RECEPTOR
18. Developing in vitro assays to transform gastrointestinal safety assessment: potential for microphysiological systems.
19. Human 3D Gastrointestinal Microtissue Barrier Function As a Predictor of Drug-Induced Diarrhea
20. Toward β-Secretase-1 Inhibitors with Improved Isoform Selectivity
21. Fragment-assisted hit investigation involving integrated HTS and fragment screening: Application to the identification of phosphodiesterase 10A (PDE10A) inhibitors
22. Deconvoluting Kinase Inhibitor Induced Cardiotoxicity
23. Mechanism of gamma-secretase cleavage activation: is gamma-secretase regulated through autoinhibition involving the presenilin-1 exon 9 loop?
24. Human 3D Gastrointestinal Microtissue Barrier Function As a Predictor of Drug-Induced Diarrhea.
25. Regulation and localization of [tyrosine.sup.216] phosphorylation of glycogen synthase kinase-3[Beta] in cellular and animal models of neuronal degeneration
26. Development of a Plate-Based Optical Biosensor Fragment Screening Methodology to Identify Phosphodiesterase 10A Inhibitors
27. Structural Insights Lead to a Negamycin Analogue with Improved Antimicrobial Activity against Gram-Negative Pathogens
28. 2,6-Disubstituted pyrazines and related analogs as NR2B site antagonists of the NMDA receptor with anti-depressant activity
29. [12] cAMP-dependent protein kinase regulatory subunit phosphorylation in intact cells
30. Developing a medium throughput cellular assay to quantify modulators of contractility using human induced pluripotent stem cell-derived cardiomyocytes
31. Human Stem Cell-Derived Cardiomyocytes in Cellular Impedance Assays: Bringing Cardiotoxicity Screening to the Front Line
32. Human induced pluripotent stem cells and their use in drug discovery for toxicity testing
33. Development of a Plate-Based Optical Biosensor Fragment Screening Methodology to Identify Phosphodiesterase 10A Inhibitors
34. Evaluation of Cellular Impedance Measures of Cardiomyocyte Cultures for Drug Screening Applications
35. Azepines and Piperidines with Dual Norepinephrine Dopamine Uptake Inhibition and Antidepressant Activity
36. Mechanism of Inhibition of Fatty Acid Amide Hydrolase by Sulfonamide-Containing Benzothiazoles: Long Residence Time Derived from Increased Kinetic Barrier and Not Exclusively from Thermodynamic Potency
37. Comparing Label-Free Biosensors for Pharmacological Screening With Cell-Based Functional Assays
38. Evaluation of Cellular Dielectric Spectroscopy, a Whole-Cell, Label-Free Technology for Drug Discovery on Gi-Coupled GPCRs
39. Neurokinin-3 Receptor-Specific Antagonists Talnetant and Osanetant Show Distinct Mode of Action in Cellular Ca2+ Mobilization but Display Similar Binding Kinetics and Identical Mechanism of Binding in Ligand Cross-Competition
40. Biological Regulation by Protein Phosphorylation
41. Non-Competitive Inhibition of Solubilized Human γ-Secretase by Pepstatin A Methylester, L-685458, Sulfonamides and Benzodiazepines
42. Mechanism of γ-Secretase Cleavage Activation: Is γ-Secretase Regulated through Autoinhibition Involving the Presenilin-1 Exon 9 Loop?
43. Parkin suppresses wild-type α-synuclein-induced toxicity in SHSY-5Y cells
44. Novel Small Molecule Inhibitors of Caspase-3 Block Cellular and Biochemical Features of Apoptosis
45. Interactions between GSK3β and caspase signalling pathways during NGF deprivation induced cell death
46. Synthesis and enzymatic evaluation of a P1 arginine aminocoumarin substrate library for trypsin-like serine proteases
47. Expression and in vitro properties of guinea pig IL-5: Comparison to human and murine orthologs
48. Specific Cleavage of Recombinant Protein τ3 between Valine-220 and Tyrosine-221 (val-309 and tyr-310 of τ4) by a Double-Stranded DNA-Stimulated Protease
49. Human tau isoforms confer distinct morphological and functional properties to stably transfected fibroblasts
50. Aggregation of tau protein by aluminum
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