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3. EHD1-dependent traffic of IGF-1 receptor to the cell surface is essential for Ewing sarcoma tumorigenesis and metastasis

Author

Chakraborty, Sukanya, Bhat, Aaqib M., Mushtaq, Insha, Luan, Haitao, Kalluchi, Achyuth, Mirza, Sameer, Storck, Matthew D., Chaturvedi, Nagendra, Lopez-Guerrero, Jose Antonio, Llombart-Bosch, Antonio, Machado, Isidro, Scotlandi, Katia, Meza, Jane L., Ghosal, Gargi, Coulter, Donald W., Jordan Rowley, M., Band, Vimla, Mohapatra, Bhopal C., and Band, Hamid

Published
2023
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6. A global collaboRAtive study of CIC-rearranged, BCOR::CCNB3-rearranged and other ultra-rare unclassified undifferentiated small round cell sarcomas (GRACefUl)

Author

Palmerini, Emanuela, Gambarotti, Marco, Italiano, Antoine, Nathenson, Michael J., Ratan, Ravin, Dileo, Palma, Provenzano, Salvatore, Jones, Robin L., DuBois, Steven G., Martin-Broto, Javier, de Alava, Enrique, Baldi, Giacomo G., Grignani, Giovanni, Ferraresi, Virginia, Brunello, Antonella, Paoluzzi, Luca, Bertulli, Rossella, Hindi, Nadia, Montemurro, Michael, Rothermundt, Christian, Cocchi, Stefania, Salguero-Aranda, Carmen, Donati, Davide, Martin, Juan D., Abdelhamid Ahmed, Amr H., Mazzocca, Alessandro, Carretta, Elisa, Cesari, Marilena, Pierini, Michela, Righi, Alberto, Sbaraglia, Marta, Laginestra, Maria A., Scotlandi, Katia, Dei Tos, Angelo P., Ibrahim, Toni, Stacchiotti, Silvia, and Vincenzi, Bruno

Published
2023
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8. Payload-delivering engineered γδ T cells display enhanced cytotoxicity, persistence, and efficacy in preclinical models of osteosarcoma

Author

Fowler, Daniel, primary, Barisa, Marta, additional, Southern, Alba, additional, Nattress, Callum, additional, Hawkins, Elizabeth, additional, Vassalou, Eleni, additional, Kanouta, Angeliki, additional, Counsell, John, additional, Rota, Enrique, additional, Vlckova, Petra, additional, Draper, Benjamin, additional, De Mooij, Tessa, additional, Farkas, Andrea, additional, Brezovjakova, Helena, additional, Baker, Alfie T., additional, Scotlandi, Katia, additional, Manara, Maria C., additional, Tape, Chris, additional, Chester, Kerry, additional, Anderson, John, additional, and Fisher, Jonathan, additional

Published
2024
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11. Correction: Identification of a novel quinoline-based DNA demethylating compound highly potent in cancer cells

Author

Zwergel, Clemens, Schnekenburger, Michael, Sarno, Federica, Battistelli, Cecilia, Manara, Maria Cristina, Stazi, Giulia, Mazzone, Roberta, Fioravanti, Rossella, Gros, Christina, Ausseil, Frédéric, Florean, Cristina, Nebbioso, Angela, Strippoli, Raffaele, Ushijima, Toshikazu, Scotlandi, Katia, Tripodi, Marco, Arimondo, Paola B., Altucci, Lucia, Diederich, Marc, Mai, Antonello, and Valente, Sergio

Published
2022
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12. Phospholipase Cδ-4 (PLCδ4) Acts as a Nuclear Player to Influence Cyclin B Expression in the Embryonal Rhabdomyosarcoma Cell Lines RD and A204.

Author

Salucci, Sara, Bavelloni, Alberto, Versari, Ilaria, Burattini, Sabrina, Bavelloni, Francesco, Gobbi, Pietro, Fanzani, Alessandro, Codenotti, Silvia, Blalock, William, Scotlandi, Katia, and Faenza, Irene

Subjects
PHOSPHOLIPASE C, MESENCHYMAL stem cells, CELL cycle, CELL lines, CELL nuclei
Abstract

Rhabdomyosarcoma (RMS), the most common form of sarcoma typical of pediatric age, arises from the malignant transformation of the mesenchymal precursors that fail to differentiate into skeletal muscle cells. Here, we investigated whether the protein phospholipase C δ4 (PLCδ4), a member of the PLC family involved in proliferation and senescence mechanisms of mesenchymal stromal stem cells, may play a role in RMS. Our molecular and morpho-functional data reveal that PLCδ4 is highly expressed in the fusion-negative, p53-positive, SMARCB1 heterozygous mutated embryonal RMS (ERMS) cell line A204, while it is poorly expressed in the ERMS cell lines RD (fusion-negative, MYC amplification, N-RAS (Q61H), homozygous mutated p53) and Hs729 (homozygous mutated p53) and the alveolar rhabdosarcoma (ARMS) cell line SJCRH30 (RH30; fusion positive, heterozygous mutated RARA, polyheterozygous mutated p53). To characterize the role of PLCδ4, the RD cell line was stably transfected with wild-type PLCδ4 (RD/PLCδ4). Overexpressed PLCδ4 mainly localized to the nucleus in RD cells and contributed to the phosphorylation of PRAS40 (T246), Chk2(T68), WNK1(T60), and Akt 1/273 (S473), as revealed by proteome profiler array analysis. Overexpression of PLCδ4 in RD cells enhanced cyclin B1 expression and resulted in G2/M-phase cell cycle arrest. In contrast, siRNA-mediated knockdown of PLCδ4 in A204 cells resulted in reduced cyclin B1 expression. Our study identifies a novel role for nuclear PLCδ4 as a regulator of cyclin B1 via Akt-dependent phosphorylation. The modulation of PLCδ4 expression and its downstream targets could represent a crucial signaling pathway to block embryonal RMS cell proliferation. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Supplementary Figure 5 from Engagement of CD99 Activates Distinct Programs in Ewing Sarcoma and Macrophages

Author

Manara, Maria Cristina, primary, Manferdini, Cristina, primary, Cristalli, Camilla, primary, Carrabotta, Marianna, primary, Santi, Spartaco, primary, De Feo, Alessandra, primary, Caldoni, Giulia, primary, Pasello, Michela, primary, Landuzzi, Lorena, primary, Lollini, Pier-Luigi, primary, Salamanna, Francesca, primary, Dominici, Sabrina, primary, Fiori, Valentina, primary, Magnani, Mauro, primary, Lisignoli, Gina, primary, and Scotlandi, Katia, primary

Published
2024
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15. Supplementary Figure 3 from Engagement of CD99 Activates Distinct Programs in Ewing Sarcoma and Macrophages

Author

Manara, Maria Cristina, primary, Manferdini, Cristina, primary, Cristalli, Camilla, primary, Carrabotta, Marianna, primary, Santi, Spartaco, primary, De Feo, Alessandra, primary, Caldoni, Giulia, primary, Pasello, Michela, primary, Landuzzi, Lorena, primary, Lollini, Pier-Luigi, primary, Salamanna, Francesca, primary, Dominici, Sabrina, primary, Fiori, Valentina, primary, Magnani, Mauro, primary, Lisignoli, Gina, primary, and Scotlandi, Katia, primary

Published
2024
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16. Data from Engagement of CD99 Activates Distinct Programs in Ewing Sarcoma and Macrophages

Author

Manara, Maria Cristina, primary, Manferdini, Cristina, primary, Cristalli, Camilla, primary, Carrabotta, Marianna, primary, Santi, Spartaco, primary, De Feo, Alessandra, primary, Caldoni, Giulia, primary, Pasello, Michela, primary, Landuzzi, Lorena, primary, Lollini, Pier-Luigi, primary, Salamanna, Francesca, primary, Dominici, Sabrina, primary, Fiori, Valentina, primary, Magnani, Mauro, primary, Lisignoli, Gina, primary, and Scotlandi, Katia, primary

Published
2024
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17. Supplementary video 1 from Engagement of CD99 Activates Distinct Programs in Ewing Sarcoma and Macrophages

Author

Manara, Maria Cristina, primary, Manferdini, Cristina, primary, Cristalli, Camilla, primary, Carrabotta, Marianna, primary, Santi, Spartaco, primary, De Feo, Alessandra, primary, Caldoni, Giulia, primary, Pasello, Michela, primary, Landuzzi, Lorena, primary, Lollini, Pier-Luigi, primary, Salamanna, Francesca, primary, Dominici, Sabrina, primary, Fiori, Valentina, primary, Magnani, Mauro, primary, Lisignoli, Gina, primary, and Scotlandi, Katia, primary

Published
2024
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18. Supplementary Figure 9 from Engagement of CD99 Activates Distinct Programs in Ewing Sarcoma and Macrophages

Author

Manara, Maria Cristina, primary, Manferdini, Cristina, primary, Cristalli, Camilla, primary, Carrabotta, Marianna, primary, Santi, Spartaco, primary, De Feo, Alessandra, primary, Caldoni, Giulia, primary, Pasello, Michela, primary, Landuzzi, Lorena, primary, Lollini, Pier-Luigi, primary, Salamanna, Francesca, primary, Dominici, Sabrina, primary, Fiori, Valentina, primary, Magnani, Mauro, primary, Lisignoli, Gina, primary, and Scotlandi, Katia, primary

Published
2024
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19. Supplementary Figure 11 from Engagement of CD99 Activates Distinct Programs in Ewing Sarcoma and Macrophages

Author

Manara, Maria Cristina, primary, Manferdini, Cristina, primary, Cristalli, Camilla, primary, Carrabotta, Marianna, primary, Santi, Spartaco, primary, De Feo, Alessandra, primary, Caldoni, Giulia, primary, Pasello, Michela, primary, Landuzzi, Lorena, primary, Lollini, Pier-Luigi, primary, Salamanna, Francesca, primary, Dominici, Sabrina, primary, Fiori, Valentina, primary, Magnani, Mauro, primary, Lisignoli, Gina, primary, and Scotlandi, Katia, primary

Published
2024
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20. Supplementary Figure 4 from Engagement of CD99 Activates Distinct Programs in Ewing Sarcoma and Macrophages

Author

Manara, Maria Cristina, primary, Manferdini, Cristina, primary, Cristalli, Camilla, primary, Carrabotta, Marianna, primary, Santi, Spartaco, primary, De Feo, Alessandra, primary, Caldoni, Giulia, primary, Pasello, Michela, primary, Landuzzi, Lorena, primary, Lollini, Pier-Luigi, primary, Salamanna, Francesca, primary, Dominici, Sabrina, primary, Fiori, Valentina, primary, Magnani, Mauro, primary, Lisignoli, Gina, primary, and Scotlandi, Katia, primary

Published
2024
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21. Supplementary Figure 2 from Engagement of CD99 Activates Distinct Programs in Ewing Sarcoma and Macrophages

Author

Manara, Maria Cristina, primary, Manferdini, Cristina, primary, Cristalli, Camilla, primary, Carrabotta, Marianna, primary, Santi, Spartaco, primary, De Feo, Alessandra, primary, Caldoni, Giulia, primary, Pasello, Michela, primary, Landuzzi, Lorena, primary, Lollini, Pier-Luigi, primary, Salamanna, Francesca, primary, Dominici, Sabrina, primary, Fiori, Valentina, primary, Magnani, Mauro, primary, Lisignoli, Gina, primary, and Scotlandi, Katia, primary

Published
2024
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22. Supplementary Table S1 from Engagement of CD99 Activates Distinct Programs in Ewing Sarcoma and Macrophages

Author

Manara, Maria Cristina, primary, Manferdini, Cristina, primary, Cristalli, Camilla, primary, Carrabotta, Marianna, primary, Santi, Spartaco, primary, De Feo, Alessandra, primary, Caldoni, Giulia, primary, Pasello, Michela, primary, Landuzzi, Lorena, primary, Lollini, Pier-Luigi, primary, Salamanna, Francesca, primary, Dominici, Sabrina, primary, Fiori, Valentina, primary, Magnani, Mauro, primary, Lisignoli, Gina, primary, and Scotlandi, Katia, primary

Published
2024
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23. Supplementary video 2 from Engagement of CD99 Activates Distinct Programs in Ewing Sarcoma and Macrophages

Author

Manara, Maria Cristina, primary, Manferdini, Cristina, primary, Cristalli, Camilla, primary, Carrabotta, Marianna, primary, Santi, Spartaco, primary, De Feo, Alessandra, primary, Caldoni, Giulia, primary, Pasello, Michela, primary, Landuzzi, Lorena, primary, Lollini, Pier-Luigi, primary, Salamanna, Francesca, primary, Dominici, Sabrina, primary, Fiori, Valentina, primary, Magnani, Mauro, primary, Lisignoli, Gina, primary, and Scotlandi, Katia, primary

Published
2024
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24. Supplementary Figure 7 from Engagement of CD99 Activates Distinct Programs in Ewing Sarcoma and Macrophages

Author

Manara, Maria Cristina, primary, Manferdini, Cristina, primary, Cristalli, Camilla, primary, Carrabotta, Marianna, primary, Santi, Spartaco, primary, De Feo, Alessandra, primary, Caldoni, Giulia, primary, Pasello, Michela, primary, Landuzzi, Lorena, primary, Lollini, Pier-Luigi, primary, Salamanna, Francesca, primary, Dominici, Sabrina, primary, Fiori, Valentina, primary, Magnani, Mauro, primary, Lisignoli, Gina, primary, and Scotlandi, Katia, primary

Published
2024
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25. Supplementary Figure 6 from Engagement of CD99 Activates Distinct Programs in Ewing Sarcoma and Macrophages

Author

Manara, Maria Cristina, primary, Manferdini, Cristina, primary, Cristalli, Camilla, primary, Carrabotta, Marianna, primary, Santi, Spartaco, primary, De Feo, Alessandra, primary, Caldoni, Giulia, primary, Pasello, Michela, primary, Landuzzi, Lorena, primary, Lollini, Pier-Luigi, primary, Salamanna, Francesca, primary, Dominici, Sabrina, primary, Fiori, Valentina, primary, Magnani, Mauro, primary, Lisignoli, Gina, primary, and Scotlandi, Katia, primary

Published
2024
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26. Supplementary Figure 8 from Engagement of CD99 Activates Distinct Programs in Ewing Sarcoma and Macrophages

Author

Manara, Maria Cristina, primary, Manferdini, Cristina, primary, Cristalli, Camilla, primary, Carrabotta, Marianna, primary, Santi, Spartaco, primary, De Feo, Alessandra, primary, Caldoni, Giulia, primary, Pasello, Michela, primary, Landuzzi, Lorena, primary, Lollini, Pier-Luigi, primary, Salamanna, Francesca, primary, Dominici, Sabrina, primary, Fiori, Valentina, primary, Magnani, Mauro, primary, Lisignoli, Gina, primary, and Scotlandi, Katia, primary

Published
2024
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27. Selective inhibition of HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the EWSR1 promoter in Ewing sarcoma

Author

García-Domínguez, Daniel J., Hajji, Nabil, Sánchez-Molina, Sara, Figuerola-Bou, Elisabet, de Pablos, Rocío M., Espinosa-Oliva, Ana M., Andrés-León, Eduardo, Terrón-Camero, Laura Carmen, Flores-Campos, Rocío, Pascual-Pasto, Guillem, Robles, María José, Machado, Isidro, Llombart-Bosch, Antonio, Magagnoli, Giovanna, Scotlandi, Katia, Carcaboso, Ángel M., Mora, Jaume, de Álava, Enrique, and Hontecillas-Prieto, Lourdes

Published
2021
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28. Contributors

Author

Akanksha, Samuel, primary, Allione, Alessandra, additional, Álvarez-Perez, Juan Carlos, additional, Andrades, Alvaro, additional, Arenas, Alberto M., additional, Baliñas-Gavira, Carlos, additional, Barth, Dominik A., additional, Bielowski, Anna, additional, Biswas, Roopa, additional, Boeri, Mattia, additional, Broseghini, Elisabetta, additional, Calin, George A., additional, Calura, Enrica, additional, Casalone, Elisabetta, additional, Constâncio, Vera, additional, Cosentino, Giulia, additional, Costa, Marina C., additional, Croce, Carlo M., additional, Cuadros, Marta, additional, Cutucache, Christine E., additional, Davidson, Ben, additional, Dika, Emi, additional, Dilmac, Sayra, additional, Dragomir, Mihnea P., additional, Drula, Rares, additional, Enguita, Francisco J., additional, Feng, Zhaohui, additional, Ferracin, Manuela, additional, Fornari, Francesca, additional, Fortunato, Orazio, additional, Gabriel, André F., additional, García, Daniel J., additional, Gramantieri, Laura, additional, Henrique, Rui, additional, Hu, Wenwei, additional, Iorio, Marilena V., additional, Jerónimo, Carmen, additional, Kamboj, Sakshi, additional, Kumar, Manoj, additional, Lawrie, Charles Henderson, additional, Leitão, Ana Lúcia, additional, Liu, Juan, additional, Lovat, Francesca, additional, Masatti, Laura, additional, Matullo, Giuseppe, additional, Medina, Pedro P., additional, Mohapatra, Swati, additional, Moisoiu, Vlad, additional, Negrini, Massimo, additional, Nguyen, Vu Hong Loan, additional, Anderson O’Brien, Jacob, additional, Ozpolat, Bulent, additional, Pardini, Barbara, additional, Patiño-Mercau, Juan Rodrigo, additional, Pazzaglia, Laura, additional, Peinado, Paola, additional, Pekarsky, Yuri, additional, Peng, Chun, additional, Petrescu, George E.D., additional, Pichler, Martin, additional, Plantamura, Ilaria, additional, Reich, Reuven, additional, Rodriguez, Maria Isabel, additional, Romualdi, Chiara, additional, Sanjuan-Hidalgo, Juan, additional, Scotlandi, Katia, additional, Shankaraiah, Ram C., additional, Slaby, Ondrej, additional, Solé, Carla, additional, Soni, Dharmendra Kumar, additional, Sozzi, Gabriella, additional, Thakur, Anamika, additional, Veronese, Angelo, additional, Visone, Rosa, additional, Vychytilova-Faltejskova, Petra, additional, and Zhang, Cen, additional

Published
2022
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30. Characterization of the molecular mechanisms mediated by the insulin-like growth factor-2 mRNA-binding proteins and Ephrin receptor A2 (EPHA2) signaling in the malignancy of CIC-DUX4 sarcomas

Author

Scotlandi, Katia, Toracchio, Lisa <1991>, Scotlandi, Katia, and Toracchio, Lisa <1991>

Abstract

Ewing sarcoma (EWS) and CIC-DUX4 sarcoma (CDS) are pediatric fusion gene-driven tumors of mesenchymal origin characterized by an extremely stable genome and limited clinical solutions. Post-transcriptional regulatory mechanisms are crucial for understanding the development of this class of tumors. RNA binding proteins (RBPs) play a crucial role in the aggressiveness of these tumors. Numerous RBP families are dysregulated in cancer, including IGF2BPs. Among these, IGF2BP3 is a negative prognostic factor in EWS because it promotes cell growth, chemoresistence, and induces the metastatic process. Based on preliminary RNA sequencing data from clinical samples of EWS vs CDS patients, three major axes that are more expressed in CDS have been identified, two of which are dissected in this PhD work. The first involves the transcription factor HMGA2, IGF2BP2-3, and IGF2; the other involves the ephrin receptor system, particularly EphA2. EphA2 is involved in numerous cellular functions during embryonic stages, and its increased expression in adult tissues is often associated with pathological conditions. In tumors, its role is controversial because it can be associated with both pro- and anti-tumoral mechanisms. In EWS, it has been shown to play a role in promoting cell migration and neoangiogenesis. Our study has confirmed that the HMGA2/IGF2BPs/IGF2 axis contributes to CDS malignancy, and Akt hyperactivation has a strong impact on migration. Using loss/gain of function models for EphA2, we confirmed that it is a substrate of Akt, and Akt hyperactivation in CDS triggers ligand-independent activation of EphA2 through phosphorylation of S897. Moreover, the combination of Trabectedin and NVP/BEZ235 partially inhibits Akt/mTOR activation, resulting in reduced tumor growth in vivo. Inhibition of EphA2 through ALWII 41_27 significantly reduces migration in vitro. The project aim is the identification of target molecules in CDS that can distinguish it from EWS and thus develop new

Published
2024

31. Biology of Ewing Sarcoma

Author

Scotlandi, Katia, Picci, Piero, editor, Manfrini, Marco, editor, Donati, Davide Maria, editor, Gambarotti, Marco, editor, Righi, Alberto, editor, Vanel, Daniel, editor, and Dei Tos, Angelo Paolo, editor

Published
2020
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32. Targeting DNA Methylation Machinery in Pediatric Solid Tumors.

Author

Cristalli, Camilla and Scotlandi, Katia

Subjects
*DNA methylation, *CELLULAR control mechanisms, *CHILDHOOD cancer, *ENZYME inhibitors, *PEDIATRIC therapy, *DNA methyltransferases
Abstract

DNA methylation is a key epigenetic regulatory mechanism that plays a critical role in a variety of cellular processes, including the regulation of cell fate during development, maintenance of cell identity, and genome stability. DNA methylation is tightly regulated by enzymatic reactions and its deregulation plays an important role in the development of cancer. Specific DNA methylation alterations have been found in pediatric solid tumors, providing new insights into the development of these tumors. In addition, DNA methylation profiles have greatly contributed to tune the diagnosis of pediatric solid tumors and to define subgroups of patients with different risks of progression, leading to the reduction in unwanted toxicity and the improvement of treatment efficacy. This review highlights the dysregulated DNA methylome in pediatric solid tumors and how this information provides promising targets for epigenetic therapies, particularly inhibitors of DNMT enzymes (DNMTis). Opportunities and limitations are considered, including the ability of DNMTis to induce viral mimicry and immune signaling by tumors. Besides intrinsic action against cancer cells, DNMTis have the potential to sensitize immune-cold tumors to immunotherapies and may represent a remarkable option to improve the treatment of challenging pediatric solid tumors. [ABSTRACT FROM AUTHOR]

Published
2024
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35. IL-1 Family Members in Bone Sarcomas

Author

Landuzzi, Lorena, primary, Ruzzi, Francesca, additional, Pellegrini, Evelin, additional, Lollini, Pier-Luigi, additional, Scotlandi, Katia, additional, and Manara, Maria Cristina, additional

Published
2024
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36. Engagement of CD99 Activates Distinct Programs in Ewing Sarcoma and Macrophages

Author

Manara, Maria Cristina, primary, Manferdini, Cristina, additional, Cristalli, Camilla, additional, Carrabotta, Marianna, additional, Santi, Spartaco, additional, De Feo, Alessandra, additional, Caldoni, Giulia, additional, Pasello, Michela, additional, Landuzzi, Lorena, additional, Lollini, Pier-Luigi, additional, Salamanna, Francesca, additional, Dominici, Sabrina, additional, Fiori, Valentina, additional, Magnani, Mauro, additional, Lisignoli, Gina, additional, and Scotlandi, Katia, additional

Published
2023
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39. Figure S2 from USP1 Expression Driven by EWS::FLI1 Transcription Factor Stabilizes Survivin and Mitigates Replication Stress in Ewing Sarcoma

Author

Mallard, Halle J., primary, Wan, Shibiao, primary, Nidhi, Prakriti, primary, Hanscom-Trofy, Yvan D., primary, Mohapatra, Bhopal, primary, Woods, Nicholas T., primary, Lopez-Guerrero, Jose Antonio, primary, Llombart-Bosch, Antonio, primary, Machado, Isidro, primary, Scotlandi, Katia, primary, Kreiling, Natasha F., primary, Perry, Megan C., primary, Mirza, Sameer, primary, Coulter, Donald W., primary, Band, Vimla, primary, Band, Hamid, primary, and Ghosal, Gargi, primary

Published
2023
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40. Supplementary Data File S1 from USP1 Expression Driven by EWS::FLI1 Transcription Factor Stabilizes Survivin and Mitigates Replication Stress in Ewing Sarcoma

Author

Mallard, Halle J., primary, Wan, Shibiao, primary, Nidhi, Prakriti, primary, Hanscom-Trofy, Yvan D., primary, Mohapatra, Bhopal, primary, Woods, Nicholas T., primary, Lopez-Guerrero, Jose Antonio, primary, Llombart-Bosch, Antonio, primary, Machado, Isidro, primary, Scotlandi, Katia, primary, Kreiling, Natasha F., primary, Perry, Megan C., primary, Mirza, Sameer, primary, Coulter, Donald W., primary, Band, Vimla, primary, Band, Hamid, primary, and Ghosal, Gargi, primary

Published
2023
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41. Data from USP1 Expression Driven by EWS::FLI1 Transcription Factor Stabilizes Survivin and Mitigates Replication Stress in Ewing Sarcoma

Author

Mallard, Halle J., primary, Wan, Shibiao, primary, Nidhi, Prakriti, primary, Hanscom-Trofy, Yvan D., primary, Mohapatra, Bhopal, primary, Woods, Nicholas T., primary, Lopez-Guerrero, Jose Antonio, primary, Llombart-Bosch, Antonio, primary, Machado, Isidro, primary, Scotlandi, Katia, primary, Kreiling, Natasha F., primary, Perry, Megan C., primary, Mirza, Sameer, primary, Coulter, Donald W., primary, Band, Vimla, primary, Band, Hamid, primary, and Ghosal, Gargi, primary

Published
2023
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45. CD99 Modulates the Proteomic Landscape of Ewing Sarcoma Cells and Related Extracellular Vesicles.

Author

De Feo, Alessandra, Manfredi, Marcello, Mancarella, Caterina, Maqueda, Joaquín J., De Giorgis, Veronica, Pignochino, Ymera, Sciandra, Marika, Cristalli, Camilla, Donadelli, Massimo, and Scotlandi, Katia

Subjects
EWING'S sarcoma, EXTRACELLULAR vesicles, CELL migration, PROTEOMICS, MASS spectrometry, FUNCTIONAL analysis
Abstract

Ewing sarcoma (EWS) is an aggressive pediatric bone tumor characterized by unmet clinical needs and an incompletely understood epigenetic heterogeneity. Here, we considered CD99, a major surface molecule hallmark of EWS malignancy. Fluctuations in CD99 expression strongly impair cell dissemination, differentiation, and death. CD99 is also loaded within extracellular vesicles (EVs), and the delivery of CD99-positive or CD99-negative EVs dynamically exerts oncogenic or oncosuppressive functions to recipient cells, respectively. We undertook mass spectrometry and functional annotation analysis to investigate the consequences of CD99 silencing on the proteomic landscape of EWS cells and related EVs. Our data demonstrate that (i) the decrease in CD99 leads to major changes in the proteomic profile of EWS cells and EVs; (ii) intracellular and extracellular compartments display two distinct signatures of differentially expressed proteins; (iii) proteomic changes converge to the modulation of cell migration and immune-modulation biological processes; and (iv) CD99-silenced cells and related EVs are characterized by a migration-suppressive, pro-immunostimulatory proteomic profile. Overall, our data provide a novel source of CD99-associated protein biomarkers to be considered for further validation as mediators of EWS malignancy and as EWS disease liquid biopsy markers. [ABSTRACT FROM AUTHOR]

Published
2024
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46. Supplementary Data 3 from Endoglin, a Novel Biomarker and Therapeutical Target to Prevent Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis

Author

González-Muñoz, Teresa, primary, Di Giannatale, Angela, primary, García-Silva, Susana, primary, Santos, Vanesa, primary, Sánchez-Redondo, Sara, primary, Savini, Claudia, primary, Graña-Castro, Osvaldo, primary, Blanco-Aparicio, Carmen, primary, Fischer, Suzanne, primary, De Wever, Olivier, primary, Creus-Bachiller, Edgar, primary, Ortega-Bertran, Sara, primary, Pisapia, David J., primary, Rodríguez-Peralto, Jose L., primary, Fernández-Rodríguez, Juana, primary, Pérez-Portabella, Cleofé Romagosa, primary, Alaggio, Rita, primary, Benassi, Maria Serena, primary, Pazzaglia, Laura, primary, Scotlandi, Katia, primary, Ratner, Nancy, primary, Yohay, Kaleb, primary, Theuer, Charles P., primary, and Peinado, Héctor, primary

Published
2023
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47. Supplementary Data 2 from Endoglin, a Novel Biomarker and Therapeutical Target to Prevent Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis

Author

González-Muñoz, Teresa, primary, Di Giannatale, Angela, primary, García-Silva, Susana, primary, Santos, Vanesa, primary, Sánchez-Redondo, Sara, primary, Savini, Claudia, primary, Graña-Castro, Osvaldo, primary, Blanco-Aparicio, Carmen, primary, Fischer, Suzanne, primary, De Wever, Olivier, primary, Creus-Bachiller, Edgar, primary, Ortega-Bertran, Sara, primary, Pisapia, David J., primary, Rodríguez-Peralto, Jose L., primary, Fernández-Rodríguez, Juana, primary, Pérez-Portabella, Cleofé Romagosa, primary, Alaggio, Rita, primary, Benassi, Maria Serena, primary, Pazzaglia, Laura, primary, Scotlandi, Katia, primary, Ratner, Nancy, primary, Yohay, Kaleb, primary, Theuer, Charles P., primary, and Peinado, Héctor, primary

Published
2023
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48. Suppl. Figure 6 from Endoglin, a Novel Biomarker and Therapeutical Target to Prevent Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis

Author

González-Muñoz, Teresa, primary, Di Giannatale, Angela, primary, García-Silva, Susana, primary, Santos, Vanesa, primary, Sánchez-Redondo, Sara, primary, Savini, Claudia, primary, Graña-Castro, Osvaldo, primary, Blanco-Aparicio, Carmen, primary, Fischer, Suzanne, primary, De Wever, Olivier, primary, Creus-Bachiller, Edgar, primary, Ortega-Bertran, Sara, primary, Pisapia, David J., primary, Rodríguez-Peralto, Jose L., primary, Fernández-Rodríguez, Juana, primary, Pérez-Portabella, Cleofé Romagosa, primary, Alaggio, Rita, primary, Benassi, Maria Serena, primary, Pazzaglia, Laura, primary, Scotlandi, Katia, primary, Ratner, Nancy, primary, Yohay, Kaleb, primary, Theuer, Charles P., primary, and Peinado, Héctor, primary

Published
2023
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49. Suppl. Figure 5 from Endoglin, a Novel Biomarker and Therapeutical Target to Prevent Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis

Author

González-Muñoz, Teresa, primary, Di Giannatale, Angela, primary, García-Silva, Susana, primary, Santos, Vanesa, primary, Sánchez-Redondo, Sara, primary, Savini, Claudia, primary, Graña-Castro, Osvaldo, primary, Blanco-Aparicio, Carmen, primary, Fischer, Suzanne, primary, De Wever, Olivier, primary, Creus-Bachiller, Edgar, primary, Ortega-Bertran, Sara, primary, Pisapia, David J., primary, Rodríguez-Peralto, Jose L., primary, Fernández-Rodríguez, Juana, primary, Pérez-Portabella, Cleofé Romagosa, primary, Alaggio, Rita, primary, Benassi, Maria Serena, primary, Pazzaglia, Laura, primary, Scotlandi, Katia, primary, Ratner, Nancy, primary, Yohay, Kaleb, primary, Theuer, Charles P., primary, and Peinado, Héctor, primary

Published
2023
Full Text
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50. Suppl. Figure 1 from Endoglin, a Novel Biomarker and Therapeutical Target to Prevent Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis

Author

González-Muñoz, Teresa, primary, Di Giannatale, Angela, primary, García-Silva, Susana, primary, Santos, Vanesa, primary, Sánchez-Redondo, Sara, primary, Savini, Claudia, primary, Graña-Castro, Osvaldo, primary, Blanco-Aparicio, Carmen, primary, Fischer, Suzanne, primary, De Wever, Olivier, primary, Creus-Bachiller, Edgar, primary, Ortega-Bertran, Sara, primary, Pisapia, David J., primary, Rodríguez-Peralto, Jose L., primary, Fernández-Rodríguez, Juana, primary, Pérez-Portabella, Cleofé Romagosa, primary, Alaggio, Rita, primary, Benassi, Maria Serena, primary, Pazzaglia, Laura, primary, Scotlandi, Katia, primary, Ratner, Nancy, primary, Yohay, Kaleb, primary, Theuer, Charles P., primary, and Peinado, Héctor, primary

Published
2023
Full Text
View/download PDF

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