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9. SARS-CoV-2 causes a specific dysfunction of the kidney proximal tubule

Author

Aboubakar, Frank, Acid, Souad, Amini, Nadia, Bailly, Sarah, Beauloye, Christophe, Castanares-Zapatero, Diego, Coche, Emmanuel, Collienne, Christine, Cornette, Pascale, De Brauwer, Isabelle, Dechamps, Mélanie, Dupriez, Florence, Froidure, Antoine, Garnir, Quentin, Gerber, Bernhard, Ghaye, Benoît, Gilard, Isabelle, Gohy, Sophie, Grégoire, Charles, Hantson, Philippe, Jacquet, Luc-Marie, Kabamba, Benoit, Kautbally, Shakeel, Lanthier, Nicolas, Larbaoui, Fatima, Liistro, Giuseppe, Maes, Frédéric, Montiel, Virginie, Mwenge, Benny, Pierard, Sophie, Pilette, Charles, Pouleur, Anne Catherine, Sogorb, Amaury, Starkel, Peter, Rodriguez-Villalobos, Hector, Thoma, Maximilien, Van Caeneghem, Olivier, Vancraeynest, David, Werion, Alexis, Belkhir, Leila, Perrot, Marie, Schmit, Gregory, Aydin, Selda, Chen, Zhiyong, Penaloza, Andrea, De Greef, Julien, Yildiz, Halil, Pothen, Lucie, Yombi, Jean Cyr, Dewulf, Joseph, Scohy, Anais, Gérard, Ludovic, Wittebole, Xavier, Laterre, Pierre-François, Miller, Sara E., Devuyst, Olivier, Jadoul, Michel, and Morelle, Johann

Published
2020
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12. Comparison of the RGM medium and the mycobacterial growth indicator tube automated system for isolation of non-tuberculous mycobacteria from sputum samples of cystic fibrosis patients in Belgium

Author

Scohy, Anaïs, Gohy, Sophie, Mathys, Vanessa, Sapriel, Guillaume, Toussaint, Laëtitia, Bressant, Florian, Zitouni, Ali, Teylaert, Marie-Noël, Vander Meeren, Marie-Christine, Colmant, Alexandre, Simon, Anne, Perry, John D., Lebecque, Patrick, and André, Emmanuel

Published
2018
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19. Nirmatrelvir-ritonavir chez les patients greffés rénaux infectés par le SARS-CoV-2 : l’expérience d’une cohorte belge

Author

Devresse, Arnaud, Briol, Sébastien, De Greef, Julien, Lemaitre, Florian, Boland, Lidvine, Haufroid, Vincent, Scohy, Anaïs, Yombi, Jean Cyr, Belkhir, Leïla, Kanaan, Nada, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Département de médecine interne et services associés, UCL - (SLuc) Département de pharmacie, and UCL - (SLuc) Service de microbiologie

Subjects
Nephrology
Published
2022

20. Attenuated anti-SARS-CoV-2 antibody response to vaccination in patients with rheumatic diseases.

Author

UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de microbiologie, Manolache, Narcis-George, Ursachi, Vasile, Scohy, Anaïs, Desmet, Charlotte, Yombi, Jean Cyr, Nzeusseu Toukap, Adrien, Stoenoiu, Maria Simona, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de microbiologie, Manolache, Narcis-George, Ursachi, Vasile, Scohy, Anaïs, Desmet, Charlotte, Yombi, Jean Cyr, Nzeusseu Toukap, Adrien, and Stoenoiu, Maria Simona

Published
2022

21. Cellular response to COVID-19 vaccines in hematologic malignancies patients: a new hope for non-responders?

Author

UCL - SSS/DDUV - Institut de Duve, UCL - SSS/DDUV/BCHM - Biochimie-Recherche métabolique, UCL - SSS/DDUV/SIGN - Cell signalling, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de médecine interne générale, UCL - (SLuc) Service de biochimie médicale, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Service d'hématologie, Saad Albichr, Imane, De Greef, Julien, Van Den Neste, Eric, Poire, Xavier, Havelange, Violaine, Vekemans, Marie-Christiane, Bailly, Sarah, Yombi, Jean Cyr, Mzougui, Samy, Scohy, Anaïs, Kabamba-Mukadi, Benoît, UCL - SSS/DDUV - Institut de Duve, UCL - SSS/DDUV/BCHM - Biochimie-Recherche métabolique, UCL - SSS/DDUV/SIGN - Cell signalling, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de médecine interne générale, UCL - (SLuc) Service de biochimie médicale, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Service d'hématologie, Saad Albichr, Imane, De Greef, Julien, Van Den Neste, Eric, Poire, Xavier, Havelange, Violaine, Vekemans, Marie-Christiane, Bailly, Sarah, Yombi, Jean Cyr, Mzougui, Samy, Scohy, Anaïs, and Kabamba-Mukadi, Benoît

Abstract

SARS-CoV-2 vaccines offered great hope in controlling the worldwide COVID-19 pandemic. At present, SARS-CoV-2 vaccines have shown excellent efficacy to prevent COVID-19 but immunocompromised patients were left-off most vaccine clinical trials albeit their extreme vulnerability. Indeed, immunosuppression is associated with a higher risk of developing severe COVID-19 with mortality rates over 30% reported in patients with hematologic malignancies (HM). [...]

Published
2022

22. Delayed Humoral Response After 2 Doses of the BNT162b2 Vaccine in a Belgian Kidney Transplant Cohort.

Author

UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (MGD) Service de néphrologie, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - (SLuc) Service de microbiologie, UCL - SSS/DDUV - Institut de Duve, UCL - (SLuc) Département de médecine interne et services associés, Georgery, Hélène, Devresse, Arnaud, Saad Albichr, Imane, Lucas, Sophie, Yombi, Jean Cyr, Belkhir, Leïla, De Greef, Julien, Scohy, Anaïs, Kabamba Mukadi, Benoît, Goffin, Eric, Kanaan, Nada, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (MGD) Service de néphrologie, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - (SLuc) Service de microbiologie, UCL - SSS/DDUV - Institut de Duve, UCL - (SLuc) Département de médecine interne et services associés, Georgery, Hélène, Devresse, Arnaud, Saad Albichr, Imane, Lucas, Sophie, Yombi, Jean Cyr, Belkhir, Leïla, De Greef, Julien, Scohy, Anaïs, Kabamba Mukadi, Benoît, Goffin, Eric, and Kanaan, Nada

Published
2022

23. Development of SARS-CoV2 humoral response including neutralizing antibodies is not sufficient to protect patients against fatal infection.

Author

UCL - SSS/DDUV - Institut de Duve, UCL - SSS/DDUV/MEXP - Médecine expérimentale, UCL - SSS/DDUV/VIRO - Virologie, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - SSS/IREC/GYNE - Pôle de Gynécologie, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - SSS/IREC/FATH - Pôle de Pharmacologie et thérapeutique, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service de biochimie médicale, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Service de soins intensifs, UCL - (SLuc) Service de médecine interne générale, UCL - (SLuc) Service de gynécologie et d'andrologie, Choteau, Mathilde, Scohy, Anaïs, Messe, Stéphane, Luyckx, Mathieu, Dechamps, Mélanie, Montiel, Virginie, Yombi, Jean Cyr, Gruson, Damien, Limaye, Nisha, Michiels, Thomas, Dumoutier, Laure, UCL - SSS/DDUV - Institut de Duve, UCL - SSS/DDUV/MEXP - Médecine expérimentale, UCL - SSS/DDUV/VIRO - Virologie, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition, UCL - SSS/IREC/GYNE - Pôle de Gynécologie, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - SSS/IREC/FATH - Pôle de Pharmacologie et thérapeutique, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service de biochimie médicale, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Service de soins intensifs, UCL - (SLuc) Service de médecine interne générale, UCL - (SLuc) Service de gynécologie et d'andrologie, Choteau, Mathilde, Scohy, Anaïs, Messe, Stéphane, Luyckx, Mathieu, Dechamps, Mélanie, Montiel, Virginie, Yombi, Jean Cyr, Gruson, Damien, Limaye, Nisha, Michiels, Thomas, and Dumoutier, Laure

Abstract

More than a year after the start of the pandemic, COVID-19 remains a global health emergency. Although the immune response against SARS-CoV-2 has been extensively studied, some points remain controversial. One is the role of antibodies in viral clearance and modulation of disease severity. While passive transfer of neutralizing antibodies protects against SARS-CoV-2 infection in animal models, titers of anti-SARS-CoV-2 antibodies have been reported to be higher in patients suffering from more severe forms of the disease. A second key question for pandemic management and vaccine design is the persistence of the humoral response. Here, we characterized the antibody response in 187 COVID-19 patients, ranging from asymptomatic individuals to patients who died from COVID-19, and including patients who recovered. We developed in-house ELISAs to measure titers of IgG, IgM and IgA directed against the RBD or N regions in patient serum or plasma, and a spike-pseudotyped neutralization assay to analyse seroneutralization. Higher titers of virus-specific antibodies were detected in patients with severe COVID-19, including deceased patients, compared to asymptomatic patients. This demonstrates that fatal infection is not associated with defective humoral response. Finally, most of recovered patients still had anti-SARS-CoV-2 IgG more than 3 months after infection.

Published
2022

24. Monoclonal Antibody Therapy in Kidney Transplant Recipients With Delta and Omicron Variants of SARS-CoV-2: A Single-Center Case Series.

Author

UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Service de médecine interne générale, UCL - (SLuc) Service de chirurgie et transplantation abdominale, Fernandes, Guillaume, Devresse, Arnaud, Scohy, Anaïs, De Greef, Julien, Yombi, Jean Cyr, Belkhir, Leïla, Darius, Tom, Mourad, Michel, Buemi, Antoine, Kabamba Mukadi, Benoît, Goffin, Eric, Kanaan, Nada, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Service de médecine interne générale, UCL - (SLuc) Service de chirurgie et transplantation abdominale, Fernandes, Guillaume, Devresse, Arnaud, Scohy, Anaïs, De Greef, Julien, Yombi, Jean Cyr, Belkhir, Leïla, Darius, Tom, Mourad, Michel, Buemi, Antoine, Kabamba Mukadi, Benoît, Goffin, Eric, and Kanaan, Nada

Abstract

Neutralizing monoclonal antibody treatments have shown promising preliminary results in kidney transplant recipients infected with SARS-CoV-2. However, their efficacy in kidney transplant recipients infected with Omicron variant has not been reported yet. Single-center retrospective study. We included all consecutive kidney transplant recipients treated with monoclonal antibodies for SARS-CoV-2 infection (positive polymerase chain reaction on nasopharyngeal swab) between June 10 2021 and January 14 2022. Forty-seven kidney transplant recipients were included. All patients had symptoms evolving for ≤ 7 days and no oxygen therapy need at monoclonal antibody infusion. Symptoms at diagnosis were mainly cough (n=25 [53%]) and fever (n=15 [32%]). Eighty-three percent of the cohort (n=39) had been vaccinated with at least 2 doses before infection, of whom 77% (n=30) had demonstrated a vaccine-induced humoral response. They were treated with either casirivimab-imdevimab (n= 16 [34%]) or sotrovimab (n= 31 [66%]) a median of 2 (ranges 0-6) days after the onset of symptoms. Except for one mild allergic reaction during casirivimab-imdevimab infusion, no side effects were reported. Median viral loads at admission (day 0) and 7 days after mAb infusion were 2,110,027 (ranges 1000-153,798,962) copies/mL and 1,000 (ranges 0-10,000,000) copies/mL, respectively. Genotypes were available for 22 kidney transplant recipients (47%). Omicron, Delta, and Gamma variants were identified in 13 (59%), 8 (36%), 1 (5%) patients, respectively. In kidney transplant recipients infected with Omicron variant, the median viral loads at day 0 and day 7 were 752,789 (ranges 4000-12,859,300) copies/mL and 1,353 (ranges 0-1,211,163) copies/mL, respectively. Two kidney transplant recipients required hospitalization immediately after sotrovimab perfusion for oxygen therapy that was weaned in 3 days allowing patients' discharge. None were admitted to the intensive care unit or died. Small sample-size, no cont

Published
2022

25. Impact of therapeutic plasma exchange on acquired vaccinal anti-SARS-CoV-2 antibodies.

Author

UCL - (SLuc) Service d'hématologie, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Département de médecine interne et services associés, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, Lambert, Catherine, Scohy, Anaïs, Yombi, Jean Cyr, Goffin, Eric, Devresse, Arnaud, UCL - (SLuc) Service d'hématologie, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Département de médecine interne et services associés, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, Lambert, Catherine, Scohy, Anaïs, Yombi, Jean Cyr, Goffin, Eric, and Devresse, Arnaud

Published
2022

26. Attenuated anti-SARS-CoV-2 antibody response to vaccination in patients with rheumatic diseases.

Author

UCL - (SLuc) Service de rhumatologie, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de microbiologie, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Centre de prise en charge (H.I.V.), UCL - (SLuc) Département de médecine interne et services associés, UCL - (SLuc) Service d'orthopédie et de traumatologie de l'appareil locomoteur, UCL - SSS/IREC/RUMA - Pôle de Pathologies rhumatismales, Manolache, Narcis-George, Ursachi, Vasile, Scohy, Anaïs, Desmet, Charlotte, Yombi, Jean Cyr, Nzeusseu Toukap, Adrien, Stoenoiu, Maria Simona, UCL - (SLuc) Service de rhumatologie, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de microbiologie, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Centre de prise en charge (H.I.V.), UCL - (SLuc) Département de médecine interne et services associés, UCL - (SLuc) Service d'orthopédie et de traumatologie de l'appareil locomoteur, UCL - SSS/IREC/RUMA - Pôle de Pathologies rhumatismales, Manolache, Narcis-George, Ursachi, Vasile, Scohy, Anaïs, Desmet, Charlotte, Yombi, Jean Cyr, Nzeusseu Toukap, Adrien, and Stoenoiu, Maria Simona

Abstract

Dear Editor, SARS-CoV-2 vaccination has demonstrated efficacy in large clin- ical trials but immunocompromised patients including patients with rheumatic diseases are often excluded. A recent letter in Jour- nal of Infection identified an anti-receptor binding domain (RBD) antibody (Ab) threshold below which protection against SARS-CoV- 2 infection is inferior to 90% [ ... ].

Published
2022

27. Dynamics of spreading of SARS-CoV-2 in a Belgian hemodialysis facility: The importance of the analysis of viral strains.

Author

UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Département de médecine interne et services associés, Labriola, Laura, Ruelle, Jean, Scohy, Anaïs, Seghers, François, Perlot, Quentin, De Greef, Julien, Desmet, Christine, Romain, Cécile, Yombi, Jean Cyr, Rodriguez-Villalobos, Hector, Kabamba Mukadi, Benoît, Jadoul, Michel, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Département de médecine interne et services associés, Labriola, Laura, Ruelle, Jean, Scohy, Anaïs, Seghers, François, Perlot, Quentin, De Greef, Julien, Desmet, Christine, Romain, Cécile, Yombi, Jean Cyr, Rodriguez-Villalobos, Hector, Kabamba Mukadi, Benoît, and Jadoul, Michel

Abstract

In-center maintenance hemodialysis (HD) patients are at high risk of acquiring coronavirus disease 2019 (COVID-19) by cross-contamination inside the unit. The aim of this study was to assess retrospectively the dynamics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission during the very first pandemic phase (March-July 2020) in a cohort of in-center maintenance HD patients and in nurses the same HD facility, using a phylogenetic approach. All SARS-CoV-2 quantitative reverse-transcription polymerase chain reaction positive patients and nurses from our HD unit-respectively 10 out of 98, and 8 out of 58- and two other positive patients dialyzed in our self-care unit were included. Whole-genome viral sequencing and phylogenetic analysis supported the cluster investigation. Five positive patients were usually dialyzed in the same room and same shift before their COVID-19 diagnosis was made. Viral sequencing performed on 4/5 patients' swabs showed no phylogenetic link between their viruses. The fifth patient (whose virus could not be sequenced) was dialyzed at the end of the dialysis room and was treated by a different nurse than the one in charge of the other patients. Three nurses shared the same virus detected in both self-care patients (one of them had been transferred to our in-center facility). The epidemiologically strongly suspected intra-unit cluster could be ruled out by viral genome sequencing. The infection control policy did not allow inter-patient contamination within the HD facility, in contrast to evidence of moderate dissemination within the nursing staff and in the satellite unit. Epidemiologic data without phylogenetic confirmation might mislead the interpretation of the dynamics of viral spreading within congregate settings.

Published
2022

28. Rapid Decline in Vaccine Induced anti-SARS-CoV-2 Antibody Titers 3 Months After Kidney Transplantation: A Case Series From Belgium.

Author

UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - (SLuc) Service de microbiologie, UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology, UCL - (SLuc) Service de médecine interne générale, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, Fernandes, Guillaume, Devresse, Arnaud, Scohy, Anaïs, Yombi, Jean Cyr, Belkhir, Leïla, De Greef, Julien, De Meyer, Martine, Mourad, Michel, Darius, Tom, Buemi, Antoine, Kabamba Mukadi, Benoît, Goffin, Eric, Kanaan, Nada, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - (SLuc) Service de microbiologie, UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology, UCL - (SLuc) Service de médecine interne générale, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, Fernandes, Guillaume, Devresse, Arnaud, Scohy, Anaïs, Yombi, Jean Cyr, Belkhir, Leïla, De Greef, Julien, De Meyer, Martine, Mourad, Michel, Darius, Tom, Buemi, Antoine, Kabamba Mukadi, Benoît, Goffin, Eric, and Kanaan, Nada

Published
2022

29. Monoclonal Antibody Therapy for SARS-CoV-2 Infection in Kidney Transplant Recipients: A Case Series From Belgium.

Author

UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Service de médecine interne générale, UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, Fernandes, Guillaume, Devresse, Arnaud, Scohy, Anaïs, Yombi, Jean Cyr, Belkhir, Leïla, De Greef, Julien, Darius, Tom, Buemi, Antoine, Kabamba Mukadi, Benoît, Goffin, Eric, Kanaan, Nada, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Service de médecine interne générale, UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, Fernandes, Guillaume, Devresse, Arnaud, Scohy, Anaïs, Yombi, Jean Cyr, Belkhir, Leïla, De Greef, Julien, Darius, Tom, Buemi, Antoine, Kabamba Mukadi, Benoît, Goffin, Eric, and Kanaan, Nada

Published
2022

30. Safety, Efficacy and Relapse of Nirmatrelvir-Ritonavir in Kidney Transplant Recipients Infected with SARS-CoV-2.

Author

UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology, UCL - SSS/IREC/CTMA - Centre de technologies moléculaires appliquées (plate-forme technologique), UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Service de biochimie médicale, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Service de chirurgie et transplantation abdominale, Devresse, Arnaud, Briol, Sébastien, De Greef, Julien, Lemaitre, Florian, Boland, Lidvine, Haufroid, Vincent, Scohy, Anaïs, Kabamba-Mukadi, Benoît, Yombi, Jean Cyr, Belkhir, Leïla, Darius, Tom, Buemi, Antoine, De Potter, Kristell, Mantegazza, Rebecca, Bearzatto, Bertrand, Goffin, Eric, Kanaan, Nada, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology, UCL - SSS/IREC/CTMA - Centre de technologies moléculaires appliquées (plate-forme technologique), UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Service de biochimie médicale, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Service de chirurgie et transplantation abdominale, Devresse, Arnaud, Briol, Sébastien, De Greef, Julien, Lemaitre, Florian, Boland, Lidvine, Haufroid, Vincent, Scohy, Anaïs, Kabamba-Mukadi, Benoît, Yombi, Jean Cyr, Belkhir, Leïla, Darius, Tom, Buemi, Antoine, De Potter, Kristell, Mantegazza, Rebecca, Bearzatto, Bertrand, Goffin, Eric, and Kanaan, Nada

Abstract

Nirmatrelvir-ritonavir (NR) has demonstrated its efficacy to decrease the risk of progression to severe COVID-19 in high-risk patients. However, evidence in infected kidney transplant recipients (KTRs) is lacking. Moreover, NR has significant and potentially harmful interactions with calcineurin inhibitors (CNIs). In this single-center retrospective study, we included all KTRs treated with NR from April 28 to June 3, 2022. A standard management strategy of CNIs dose adaptation (discontinuation of tacrolimus 12 hours before the start of NR and administration of 20% the cyclosporine dose) and laboratory follow-up was applied. Fourteen patients were included. Compared to day-0 (day before NR initiation), day-7 plasma creatinine concentrations and SARS-CoV-2 viral loads were similar (p = 0.866) and decreased (p=0.002), respectively. CNIs trough concentrations at the end of the treatment were satisfactory, with nevertheless high individual variability. After a median follow-up time of 34 days, no death nor viral pneumonia were observed. However, 2 patients experienced early SARS-CoV-2 infection relapses (at day-10 and day-21) associated with an increase in SARS-CoV-2 viral loads. NR can be used in KTRs but requires a strict protocol of drug adaptation. We observed two cases of early relapse after NR treatment that need further investigations.

Published
2022

31. Lessons for the clinical nephrologist: lumasiran as the future cornerstone treatment for patients with primary hyperoxaluria type 1?

Author

UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Centre de génétique médicale UCL, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Département de pédiatrie, UCL - (SLuc) Service de pédiatrie générale, Gillion, Valentine, Dahan, Karin, Scohy, Anaïs, Devresse, Arnaud, Godefroid, Nathalie, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Centre de génétique médicale UCL, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Département de pédiatrie, UCL - (SLuc) Service de pédiatrie générale, Gillion, Valentine, Dahan, Karin, Scohy, Anaïs, Devresse, Arnaud, and Godefroid, Nathalie

Published
2022

32. Nirmatrelvir-ritonavir chez les patients greffés rénaux infectés par le SARS-CoV-2 : l’expérience d’une cohorte belge

Author

UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Département de médecine interne et services associés, UCL - (SLuc) Département de pharmacie, UCL - (SLuc) Service de microbiologie, Devresse, Arnaud, Briol, Sébastien, De Greef, Julien, Lemaitre, Florian, Boland, Lidvine, Haufroid, Vincent, Scohy, Anaïs, Yombi, Jean Cyr, Belkhir, Leïla, Kanaan, Nada, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Département de médecine interne et services associés, UCL - (SLuc) Département de pharmacie, UCL - (SLuc) Service de microbiologie, Devresse, Arnaud, Briol, Sébastien, De Greef, Julien, Lemaitre, Florian, Boland, Lidvine, Haufroid, Vincent, Scohy, Anaïs, Yombi, Jean Cyr, Belkhir, Leïla, and Kanaan, Nada

Published
2022

33. Safety and Efficiency of Molnupiravir for COVID-19 Patients with Advanced CKD

Author

UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Département de pharmacie, UCL - (SLuc) Département de médecine interne et services associés, Dufour, Inès, Devresse, Arnaud, Scohy, Anaïs, Briquet, Caroline, Georgery, Hélène, Delaey, Philippe, De Greef, Julien, Goffin, Eric, Labriola, Laura, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Département de pharmacie, UCL - (SLuc) Département de médecine interne et services associés, Dufour, Inès, Devresse, Arnaud, Scohy, Anaïs, Briquet, Caroline, Georgery, Hélène, Delaey, Philippe, De Greef, Julien, Goffin, Eric, and Labriola, Laura

Published
2022

34. In Reply to 'Kidney Transplant Recipients With COVID-19 and Monoclonal Antibody Therapy: Additional Considerations'.

Author

UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service de pathologie cardiovasculaire, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Service de médecine interne générale, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Service de chirurgie et transplantation abdominale, Fernandes, Guillaume, Devresse, Arnaud, Scohy, Anaïs, De Greef, Julien, Yombi, Jean Cyr, Belkhir, Leïla, Darius, Tom, Mourad, Michel, Buemi, Antoine, Kabamba-Mukadi, Benoît, Goffin, Eric, Kanaan, Nada, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service de pathologie cardiovasculaire, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Service de médecine interne générale, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Service de chirurgie et transplantation abdominale, Fernandes, Guillaume, Devresse, Arnaud, Scohy, Anaïs, De Greef, Julien, Yombi, Jean Cyr, Belkhir, Leïla, Darius, Tom, Mourad, Michel, Buemi, Antoine, Kabamba-Mukadi, Benoît, Goffin, Eric, and Kanaan, Nada

Abstract

We thank Mungmunpuntipantip and Wiwanitkit1 for their constructive comments. Among the 47 kidney transplant recipients included in this study, 17 had antihuman leukocyte antigen antibodies detected within 2 years prior to infection, but none had donor-specific antibodies.2 Antihuman leukocyte antigen antibody status was not available for 6 patients. No patient was treated for acute rejection in the 2 years prior to infection. ^...]

Published
2022

35. A comparative analysis of the outcomes of patients with influenza or COVID-19 in a tertiary hospital in Belgium.

Author

UCL - SSS/IREC/EPID - Pôle d'épidémiologie et biostatistique, UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service de médecine interne générale, UCL - (SLuc) Service de microbiologie, Wallemacq, Silvio, Danwang, Celestin, Scohy, Anaïs, Belkhir, Leïla, De Greef, Julien, Kabamba-Mukadi, Benoît, Yombi, Jean Cyr, UCL - SSS/IREC/EPID - Pôle d'épidémiologie et biostatistique, UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service de médecine interne générale, UCL - (SLuc) Service de microbiologie, Wallemacq, Silvio, Danwang, Celestin, Scohy, Anaïs, Belkhir, Leïla, De Greef, Julien, Kabamba-Mukadi, Benoît, and Yombi, Jean Cyr

Abstract

INTRODUCTION: The COVID-19 pandemic has emerged as a global health problem, associated with high morbidity and mortality rates. The aim of this study was to compare the outcomes of hospitalized patients with COVID-19 or with seasonal influenza in a teaching hospital in Belgium. METHODS: In this retrospective, single-center cohort study, 1384 patients with COVID-19 and 226 patients with influenza were matched using a propensity score with a ratio of 3:1. Primary outcomes included admission to intensive care unit (ICU), intubation rates, hospital length of stay, readmissions within 30 days and in-hospital mortality. Secondary outcomes included pulmonary bacterial superinfection, cardiovascular complications and ECMO. RESULTS: Based on the analysis of the matched sample, patients with influenza had an increased risk of readmission within 30 days (Risk Difference (RD): 0.07, 95% CI: 0.03 to 0.11) and admission to intensive care unit (RD: 0.09, 95% CI: 0.03 to 0.15) compared with those with COVID-19. Patients with influenza had also more pulmonary bacterial superinfections (46.2% vs 7.4%) and more cardiovascular complications (32% vs 3.9%) than patients with COVID-19.However, a two-fold increased risk of mortality (RD: -0.10, 95% CI: 0.15 to -0.05) was observed in COVID-19 compared to influenza. ECMO was also more required among the COVID-19 patients who died than among influenza patients (5% vs 0%). CONCLUSIONS: COVID-19 is associated with a higher in-hospital mortality compared to influenza infection, despite a high rate of ICU admission in the influenza group. These findings highlighted that the severity of hospitalized patients with influenza should not be underestimated.

Published
2022

37. Safety and Efficiency of Molnupiravir for COVID-19 Patients with Advanced CKD

Author

Dufour, Inès, Devresse, Arnaud, Scohy, Anaïs, Briquet, Caroline, Georgery, Hélène, Delaey, Philippe, De Greef, Julien, Goffin, Eric, Labriola, Laura, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Département de pharmacie, and UCL - (SLuc) Département de médecine interne et services associés

Published
2022

38. Dynamics of spreading of SARS‐CoV‐2 in a Belgian hemodialysis facility: The importance of the analysis of viral strains

Author

Labriola, Laura, primary, Ruelle, Jean, additional, Scohy, Anaïs, additional, Seghers, François, additional, Perlot, Quentin, additional, De Greef, Julien, additional, Desmet, Christine, additional, Romain, Cécile, additional, Yombi, Jean Cyr, additional, Rodriguez‐Villalobos, Hector, additional, Kabamba, Benoît, additional, and Jadoul, Michel, additional

Published
2021
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39. Immunogenicity of BNT162b2 SARS-CoV-2 Vaccine in a Multicenter Cohort of Nursing Home Residents Receiving Maintenance Hemodialysis

Author

Labriola, Laura, primary, Scohy, Anaïs, additional, Van Regemorter, Elliott, additional, Robert, Arnaud, additional, Clerbaux, Gaëtan, additional, Gillerot, Gaelle, additional, Pochet, Jean-Michel, additional, Biller, Pauline, additional, De Schuiteneer, Manuel, additional, Morelle, Johann, additional, Yombi, Jean Cyr, additional, Kabamba, Benoît, additional, Rodriguez-Villalobos, Hector, additional, and Jadoul, Michel, additional

Published
2021
Full Text
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42. Cellular response to COVID-19 vaccines in hematologic malignancies patients: a new hope for non-responders?

Author

Saad Albichr, Imane, primary, De Greef, Julien, additional, Van Den Neste, Eric, additional, Poiré, Xavier, additional, Havelange, Violaine, additional, Vekemans, Marie-Christiane, additional, Bailly, Sarah, additional, Yombi, Jean-Cyr, additional, Mzougui, Samy, additional, Scohy, Anaïs, additional, and Kabamba-Mukadi, Benoît, additional

Published
2021
Full Text
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45. Serum uric acid, disease severity and outcomes in COVID-19

Author

Dufour, Inès, Wérion, Alexis, Belkhir, Leïla, Wisniewska, Anastazja, Perrot, Marie, De Greef, Julien, Schmit, Gregory, Yombi, Jean Cyr, Wittebole, Xavier, Laterre, Pierre-François, Jadoul, Michel, Gerard, Ludovic, Morelle, Johann, CUSL COVID-19 Research Group, Beauloye, Christophe, Pothen, Lucie, Rodriguez-Villalobos, Hector, Scohy, Anaïs, Thoma, Maximilien, Van Caeneghem, Olivier, Yildiz, Halil, Collienne, Christine, Dechamps, Mélanie, Dupriez, Florence, Hantson, Philippe, Jacquet, Luc-Marie, Kabamba-Mukadi, Benoît, Larbaoui, Fatima, Penaloza-Baeza, Andrea, Montiel, Virginie, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology, UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service d'anatomie pathologique, UCL - (SLuc) Service de soins intensifs, UCL - (SLuc) Service d'hématologie, UCL - (SLuc) Service de médecine interne générale, UCL - (SLuc) Service de néphrologie, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, and UCL - (SLuc) Service de microbiologie

Subjects
Male, medicine.medical_specialty, Organic Cation Transport Proteins, medicine.medical_treatment, Critical Illness, Organic Anion Transporters, 030204 cardiovascular system & hematology, Critical Care and Intensive Care Medicine, Asymptomatic, Gastroenterology, Severity of Illness Index, Cohort Studies, Kidney Tubules, Proximal, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Mechanical ventilation, Belgium, Internal medicine, Severity of illness, Outcome Assessment, Health Care, medicine, Humans, Proximal tubule, 030212 general & internal medicine, Hypouricemia, Aged, Retrospective Studies, Acute respiratory distress syndrome, Proportional hazards model, business.industry, RC86-88.9, SARS-CoV-2, Research, Hazard ratio, COVID-19, Medical emergencies. Critical care. Intensive care. First aid, Middle Aged, medicine.disease, Uric Acid, chemistry, Respiratory failure, Proximal tube, Uric acid, medicine.symptom, business
Abstract

Background The severity of coronavirus disease 2019 (COVID-19) is highly variable between individuals, ranging from asymptomatic infection to critical disease with acute respiratory distress syndrome requiring mechanical ventilation. Such variability stresses the need for novel biomarkers associated with disease outcome. As SARS-CoV-2 infection causes a kidney proximal tubule dysfunction with urinary loss of uric acid, we hypothesized that low serum levels of uric acid (hypouricemia) may be associated with severity and outcome of COVID-19. Methods In a retrospective study using two independent cohorts, we investigated and validated the prevalence, kinetics and clinical correlates of hypouricemia among patients hospitalized with COVID-19 to a large academic hospital in Brussels, Belgium. Survival analyses using Cox regression and a competing risk approach assessed the time to mechanical ventilation and/or death. Confocal microscopy assessed the expression of urate transporter URAT1 in kidney proximal tubule cells from patients who died from COVID-19. Results The discovery and validation cohorts included 192 and 325 patients hospitalized with COVID-19, respectively. Out of the 517 patients, 274 (53%) had severe and 92 (18%) critical COVID-19. In both cohorts, the prevalence of hypouricemia increased from 6% upon admission to 20% within the first days of hospitalization for COVID-19, contrasting with a very rare occurrence (P P P Conclusions Among patients with COVID-19 requiring hospitalization, low serum levels of uric acid are common and associate with disease severity and with progression to respiratory failure requiring invasive mechanical ventilation.

Published
2021

46. T cell and Antibody Response after two Doses of the BNT162b2 Vaccine in a Belgian Cohort of Kidney Transplant Recipients

Author

Devresse, Arnaud, Saad Albichr, Imane, Georgery, Hélène, Yombi, Jean Cyr, De Greef, Julien, Belkhir, Leïla, Mzougui, Samy, Scohy, Anaïs, Darius, Tom, Buemi, Antoine, Goffin, Eric, Kabamba-Mukadi, Benoît, Kanaan, Nada, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Département de médecine interne et services associés, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, and UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology

Subjects
Transplantation
Published
2021

47. Dynamics of spreading of SARS-CoV-2 in a Belgian hemodialysis facility: The importance of the analysis of viral strains.

Author

UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (MGD) Service de néphrologie, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Département de médecine interne et services associés, Labriola, Laura, Ruelle, Jean, Scohy, Anaïs, Seghers, François, Perlot, Quentin, De Greef, Julien, Desmet, Christine, Romain, Cécile, Yombi, Jean Cyr, Rodriguez-Villalobos, Hector, Kabamba Mukadi, Benoît, Jadoul, Michel, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - (MGD) Service de néphrologie, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Département de médecine interne et services associés, Labriola, Laura, Ruelle, Jean, Scohy, Anaïs, Seghers, François, Perlot, Quentin, De Greef, Julien, Desmet, Christine, Romain, Cécile, Yombi, Jean Cyr, Rodriguez-Villalobos, Hector, Kabamba Mukadi, Benoît, and Jadoul, Michel

Abstract

In-center maintenance hemodialysis (HD) patients are at high risk of acquiring coronavirus disease 2019 (COVID-19) by cross-contamination inside the unit. The aim of this study was to assess retrospectively the dynamics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission during the very first pandemic phase (March-July 2020) in a cohort of in-center maintenance HD patients and in nurses the same HD facility, using a phylogenetic approach. All SARS-CoV-2 quantitative reverse-transcription polymerase chain reaction positive patients and nurses from our HD unit-respectively 10 out of 98, and 8 out of 58- and two other positive patients dialyzed in our self-care unit were included. Whole-genome viral sequencing and phylogenetic analysis supported the cluster investigation. Five positive patients were usually dialyzed in the same room and same shift before their COVID-19 diagnosis was made. Viral sequencing performed on 4/5 patients' swabs showed no phylogenetic link between their viruses. The fifth patient (whose virus could not be sequenced) was dialyzed at the end of the dialysis room and was treated by a different nurse than the one in charge of the other patients. Three nurses shared the same virus detected in both self-care patients (one of them had been transferred to our in-center facility). The epidemiologically strongly suspected intra-unit cluster could be ruled out by viral genome sequencing. The infection control policy did not allow inter-patient contamination within the HD facility, in contrast to evidence of moderate dissemination within the nursing staff and in the satellite unit. Epidemiologic data without phylogenetic confirmation might mislead the interpretation of the dynamics of viral spreading within congregate settings.

Published
2021

48. Immunogenicity of BNT162b2 SARS-CoV-2 Vaccine in a Multicenter Cohort of Nursing Home Residents Receiving Maintenance Hemodialysis.

Author

UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Service de médecine interne générale, Labriola, Laura, Scohy, Anaïs, Van Regemorter, Elliott, Robert, Arnaud, Clerbaux, Gaëtan, Gillerot, Gaelle, Pochet, Jean-Michel, Biller, Pauline, De Schuiteneer, Manuel, Morelle, Johann, Yombi, Jean Cyr, Kabamba, Benoît, Rodriguez-Villalobos, Hector, Jadoul, Michel, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Service de médecine interne générale, Labriola, Laura, Scohy, Anaïs, Van Regemorter, Elliott, Robert, Arnaud, Clerbaux, Gaëtan, Gillerot, Gaelle, Pochet, Jean-Michel, Biller, Pauline, De Schuiteneer, Manuel, Morelle, Johann, Yombi, Jean Cyr, Kabamba, Benoît, Rodriguez-Villalobos, Hector, and Jadoul, Michel

Published
2021

49. Low rates of humoral response to BNT162b2 SARS-CoV-2 vaccination in patients with immune-mediated kidney diseases treated with rituximab.

Author

UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de microbiologie, Demoulin, Nathalie, Scohy, Anaïs, Gillion, Valentine, Godefroid, Nathalie, Jadoul, Michel, Morelle, Johann, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - (SLuc) Service de microbiologie, Demoulin, Nathalie, Scohy, Anaïs, Gillion, Valentine, Godefroid, Nathalie, Jadoul, Michel, and Morelle, Johann

Published
2021

50. The Second Wave of COVID-19 Disease in a Kidney Transplant Recipient Cohort: A Single-center Experience in Belgium.

Author

UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - (SLuc) Service de médecine interne générale, Georgery, Hélène, Devresse, Arnaud, Scohy, Anaïs, Kabamba-Mukadi, Benoît, Darius, Tom, Buemi, Antoine, De Greef, Julien, Belkhir, Leïla, Yombi, Jean Cyr, Goffin, Eric, Kanaan, Nada, UCL - SSS/IREC/NEFR - Pôle de Néphrologie, UCL - SSS/IREC/MBLG - Pôle de Microbiologie médicale, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology, UCL - (SLuc) Service de néphrologie, UCL - (SLuc) Service de microbiologie, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - (SLuc) Service de médecine interne générale, Georgery, Hélène, Devresse, Arnaud, Scohy, Anaïs, Kabamba-Mukadi, Benoît, Darius, Tom, Buemi, Antoine, De Greef, Julien, Belkhir, Leïla, Yombi, Jean Cyr, Goffin, Eric, and Kanaan, Nada

Abstract

The first wave of coronavirus disease 2019 (COVID-19) was particularly dramatic for kidney transplant recipients (KTRs) around the world.1 A recent European registry study showed 28-day mortality and intensive care unit (ICU) admission rates at 22% and 21%, respectively.2 In the United States, a multicenter cohort study revealed a 28-day mortality rate at 18%.3 Fortunately, patients from our tertiary KT center were less impacted with mortality and ICU admission rates at 11% and 11%, respectively. [...]

Published
2021

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