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4. Validation of Segmental Post-PCI Physiological Gradients With IVUS-Detected Focal Lesions and Stent Underexpansion

Author

Neleman, Tara, Scoccia, Alessandra, Groenland, Frederik T.W., Ziedses des Plantes, Annemieke C., van Zandvoort, Laurens J.C., Ligthart, Jurgen M.R., Witberg, Karen T., Lenzen, Mattie J., Boersma, Eric, Nuis, Rutger-Jan, den Dekker, Wijnand K., Diletti, Roberto, Wilschut, Jeroen, Zijlstra, Felix, Van Mieghem, Nicolas M., and Daemen, Joost

Published
2023
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7. Vessel fractional flow reserve-based non-culprit lesion reclassification in patients with ST-segment elevation myocardial infarction: Impact on treatment strategy and clinical outcome (FAST STEMI I study)

Author

Groenland, Frederik T.W., Huang, Jager, Scoccia, Alessandra, Neleman, Tara, Ziedses Des Plantes, Annemieke C., Nuis, Rutger-Jan, den Dekker, Wijnand K., Wilschut, Jeroen M., Diletti, Roberto, Kardys, Isabella, Van Mieghem, Nicolas M., and Daemen, Joost

Published
2023
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9. Angio-Based Fractional Flow Reserve, Functional Pattern of Coronary Artery Disease, and Prediction of Percutaneous Coronary Intervention Result: a Proof-of-Concept Study

Author

Biscaglia, Simone, Uretsky, Barry F., Tebaldi, Matteo, Erriquez, Andrea, Brugaletta, Salvatore, Cerrato, Enrico, Quadri, Giorgio, Spitaleri, Giosafat, Colaiori, Iginio, Di Girolamo, Domenico, Scoccia, Alessandra, Zucchetti, Ottavio, D’Aniello, Emanuele, Manfrini, Marco, Pavasini, Rita, Barbato, Emanuele, and Campo, Gianluca

Published
2022
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11. The prognostic value of angiography-based vessel fractional flow reserve after percutaneous coronary intervention: The FAST Outcome study

Author

Neleman, Tara, Scoccia, Alessandra, Masdjedi, Kaneshka, Tomaniak, Mariusz, Ligthart, Jurgen M.R., Witberg, Karen T., Vermaire, Alise, Wolff, Quinten, Visser, Leon, Cummins, Paul, Kardys, Isabella, Wilschut, Jeroen, Diletti, Roberto, Den Dekker, Wijnand K., Zijlstra, Felix, Van Mieghem, Nicolas M., and Daemen, Joost

Published
2022
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12. Intravascular ultrasound-guided versus coronary angiography-guided percutaneous coronary intervention in patients with acute myocardial infarction: A systematic review and meta-analysis

Author

Groenland, Frederik T.W., Neleman, Tara, Kakar, Hala, Scoccia, Alessandra, Ziedses des Plantes, Annemieke C., Clephas, Pascal R.D., Chatterjee, Sraman, Zhu, Mahova, den Dekker, Wijnand K., Diletti, Roberto, Zijlstra, Felix, Mahmoud, Karim D., Van Mieghem, Nicolas M., and Daemen, Joost

Published
2022
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13. Impact of chronic obstructive pulmonary disease on short-term outcome in patients with ST-elevation myocardial infarction during COVID-19 pandemic: insights from the international multicenter ISACS-STEMI registry

Author

De Luca, Giuseppe, Nardin, Matteo, Algowhary, Magdy, Uguz, Berat, Oliveira, Dinaldo C., Ganyukov, Vladimir, Zimbakov, Zan, Cercek, Miha, Okkels Jensen, Lisette, Loh, Poay Huan, Calmac, Lucian, Roura Ferrer, Gerard, Quadros, Alexandre, Milewski, Marek, Scotto di Uccio, Fortunato, von Birgelen, Clemens, Versaci, Francesco, Ten Berg, Jurrien, Casella, Gianni, Wong Sung Lung, Aaron, Kala, Petr, Díez Gil, José Luis, Carrillo, Xavier, Dirksen, Maurits, Becerra-Munoz, Victor M., Lee, Michael Kang-yin, Arifa Juzar, Dafsah, de Moura Joaquim, Rodrigo, Paladino, Roberto, Milicic, Davor, Davlouros, Periklis, Bakraceski, Nikola, Zilio, Filippo, Donazzan, Luca, Kraaijeveld, Adriaan, Galasso, Gennaro, Lux, Arpad, Marinucci, Lucia, Guiducci, Vincenzo, Menichelli, Maurizio, Scoccia, Alessandra, Yamac, Aylin Hatice, Ugur Mert, Kadir, Flores Rios, Xacobe, Kovarnik, Tomas, Kidawa, Michal, Moreu, Josè, Flavien, Vincent, Fabris, Enrico, Martínez-Luengas, Iñigo Lozano, Boccalatte, Marco, Bosa Ojeda, Francisco, Arellano-Serrano, Carlos, Caiazzo, Gianluca, Cirrincione, Giuseppe, Kao, Hsien-Li, Sanchis Forés, Juan, Vignali, Luigi, Pereira, Helder, Manzo, Stephane, Ordoñez, Santiago, Özkan, Alev Arat, Scheller, Bruno, Lehtola, Heidi, Teles, Rui, Mantis, Christos, Antti, Ylitalo, Brum Silveira, João A., Zoni, Rodrigo, Bessonov, Ivan, Savonitto, Stefano, Kochiadakis, George, Alexopoulos, Dimitrios, Uribe, Carlos E., Kanakakis, John, Faurie, Benjamin, Gabrielli, Gabriele, Gutierrez Barrios, Alejandro, Bachini, Juan Pablo, Rocha, Alex, Tam, Frankie Chor-Cheung, Rodriguez, Alfredo, Lukito, Antonia Anna, Saint-Joy, Veauthyelau, Pessah, Gustavo, Tuccillo, Andrea, Cortese, Giuliana, Parodi, Guido, Bouraghda, Mohamed Abed, Kedhi, Elvin, Lamelas, Pablo, Suryapranata, Harry, and Verdoia, Monica

Published
2022
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14. The hidden interplay between sex and COVID-19 mortality: the role of cardiovascular calcification

Author

Cereda, Alberto, Toselli, Marco, Palmisano, Anna, Vignale, Davide, Leone, Riccardo, Nicoletti, Valeria, Gnasso, Chiara, Mangieri, Antonio, Khokhar, Arif, Campo, Gianluca, Scoccia, Alessandra, Bertini, Matteo, Loffi, Marco, Sergio, Pietro, Andreini, Daniele, Pontone, Gianluca, Iannopollo, Gianmarco, Nannini, Tommaso, Ippolito, Davide, Bellani, Giacomo, Patelli, Gianluigi, Besana, Francesca, Vignali, Luigi, Sverzellati, Nicola, Iannaccone, Mario, Vaudano, Paolo Giacomo, Sangiorgi, Giuseppe Massimo, Turchio, Piergiorgio, Monello, Alberto, Tumminello, Gabriele, Maggioni, Aldo Pietro, Rapezzi, Claudio, Colombo, Antonio, Giannini, Francesco, and Esposito, Antonio

Published
2021
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15. Renin-angiotensin system inhibitors and mortality among diabetic patients with STEMI undergoing mechanical reperfusion during the COVID-19 pandemic

Author

De Luca, Giuseppe, Nardin, Matteo, Algowhary, Magdy, Uguz, Berat, Oliveira, Dinaldo C, Ganyukov, Vladimir, Zimbakov, Zan, Cercek, Miha, Jensen, Lisette Okkels, LOH, Poay Huan, Calmac, Lucian, Roura Ferrer, Gerard, Quadros, Alexandre, Milewski, Marek, Scotto di Uccio, Fortunato, von Birgelen, Clemens, Versaci, Francesco, Ten Berg, Jurrien, Casella, Gianni, Lung, Aaron Wong Sung, Kala, Petr, Díez Gil, José Luis, Carrillo, Xavier, Dirksen, Maurits, Becerra-Munoz, Victor M., Lee, Michael Kang-yin, Juzar, Dafsah Arifa, de Moura Joaquim, Rodrigo, Paladino, Roberto, Milicic, Davor, Davlouros, Periklis, Bakraceski, Nikola, Zilio, Filippo, Donazzan, Luca, Kraaijeveld, Adriaan, Galasso, Gennaro, Lux, Arpad, Marinucci, Lucia, Guiducci, Vincenzo, Menichelli, Maurizio, Scoccia, Alessandra, Yamac, Aylin Hatice, Mert, Kadir Ugur, Flores Rios, Xacobe, Kovarnik, Tomas, Kidawa, Michal, Moreu, Josè, Flavien, Vincent, Fabris, Enrico, Martínez-Luengas, Iñigo Lozano, Boccalatte, Marco, Bosa Ojeda, Francisco, Arellano-Serrano, Carlos, Caiazzo, Gianluca, Cirrincione, Giuseppe, Kao, Hsien-Li, Sanchis Forés, Juan, Vignali, Luigi, Pereira, Helder, Manzo, Stephane, Ordoñez, Santiago, Arat Özkan, Alev, Scheller, Bruno, Lehtola, Heidi, Teles, Rui, Mantis, Christos, Antti, Ylitalo, Brum Silveira, João António, Zoni, Rodrigo, Bessonov, Ivan, Savonitto, Stefano, Kochiadakis, George, Alexopulos, Dimitrios, Uribe, Carlos E, Kanakakis, John, Faurie, Benjamin, Gabrielli, Gabriele, Gutierrez Barrios, Alejandro, Bachini, Juan Pablo, Rocha, Alex, Tam, Frankie Chor-Cheung, Rodriguez, Alfredo, Lukito, Antonia Anna, Saint-Joy, Veauthyelau, Pessah, Gustavo, Tuccillo, Andrea, Cortese, Giuliana, Parodi, Guido, Bouraghda, Mohammed Abed, Kedhi, Elvin, Lamelas, Pablo, Suryapranata, Harry, and Verdoia, Monica

Published
2021
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16. Coronary and total thoracic calcium scores predict mortality and provides pathophysiologic insights in COVID-19 patients

Author

Giannini, Francesco, Toselli, Marco, Palmisano, Anna, Cereda, Alberto, Vignale, Davide, Leone, Riccardo, Nicoletti, Valeria, Gnasso, Chiara, Monello, Alberto, Manfrini, Marco, Khokhar, Arif, Sticchi, Alessandro, Biagi, Andrea, Turchio, Piergiorgio, Tacchetti, Carlo, Landoni, Giovanni, Boccia, Edda, Campo, Gianluca, Scoccia, Alessandra, Ponticelli, Francesco, Danzi, Gian Battista, Loffi, Marco, Muri, Margherita, Pontone, Gianluca, Andreini, Daniele, Mancini, Elisabetta Maria, Casella, Gianni, Iannopollo, Gianmarco, Nannini, Tommaso, Ippolito, Davide, Bellani, Giacomo, Franzesi, Camillo Talei, Patelli, Gianluigi, Besana, Francesca, Costa, Claudia, Vignali, Luigi, Benatti, Giorgio, Sverzellati, Nicola, Scarnecchia, Elisa, Lombardo, Francesco Paolo, Anastasio, Fabio, Iannaccone, Mario, Vaudano, Paolo Giacomo, Pacielli, Alberto, Baffoni, Lucio, Gardi, Iljia, Cesini, Elisabetta, Sperandio, Massimiliano, Micossi, Chiara, De Carlini, Caterina Chiara, Spreafico, Cristiano, Maggiolini, Stefano, Bonaffini, Pietro Andrea, Iacovoni, Attilio, Sironi, Sandro, Senni, Michele, Fominskiy, Evgeny, De Cobelli, Francesco, Maggioni, Aldo Pietro, Rapezzi, Claudio, Ferrari, Roberto, Colombo, Antonio, and Esposito, Antonio

Published
2021
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17. Impact of SARS-CoV-2 positivity on clinical outcome among STEMI patients undergoing mechanical reperfusion: Insights from the ISACS STEMI COVID 19 registry

Author

De Luca, Giuseppe, Debel, Niels, Cercek, Miha, Jensen, Lisette Okkels, Vavlukis, Marija, Calmac, Lucian, Johnson, Tom, Ferrer, Gerard Rourai, Ganyukov, Vladimir, Wojakowski, Wojtek, Kinnaird, Tim, von Birgelen, Clemens, Cottin, Yves, IJsselmuiden, Alexander, Tuccillo, Bernardo, Versaci, Francesco, Royaards, Kees-Jan, Berg, Jurrien ten, Laine, Mika, Dirksen, Maurits, Siviglia, Massimo, Casella, Gianni, Kala, Petr, Díez Gil, José Luis, Banning, Adrian, Becerra, Victor, De Simone, Ciro, Santucci, Andrea, Carrillo, Xavier, Scoccia, Alessandra, Amoroso, Giovanni, van't Hof, Arnoud WJ., Kovarnik, Tomas, Tsigkas, Grigorios, Mehilli, Julinda, Gabrielli, Gabriele, Rios, Xacobe Flores, Bakraceski, Nikola, Levesque, Sébastien, Cirrincione, Giuseppe, Guiducci, Vincenzo, Kidawa, Michał, Spedicato, Leonardo, Marinucci, Lucia, Ludman, Peter, Zilio, Filippo, Galasso, Gennaro, Fabris, Enrico, Menichelli, Maurizio, Garcia-Touchard, Arturo, Manzo, Stephane, Caiazzo, Gianluca, Moreu, Jose, Forés, Juan Sanchis, Donazzan, Luca, Vignali, Luigi, Teles, Rui, Benit, Edouard, Agostoni, Pierfrancesco, Ojeda, Francisco Bosa, Lehtola, Heidi, Camacho-Freiere, Santiago, Kraaijeveld, Adriaan, Antti, Ylitalo, Boccalatte, Marco, Deharo, Pierre, Martínez-Luengas, Iñigo Lozano, Scheller, Bruno, Varytimiadi, Efthymia, Moreno, Raul, Uccello, Giuseppe, Faurie, Benjamin, Gutierrez Barrios, Alejandro, Milewski, Marek, Bruwiere, Ewout, Smits, Pieter, Wilbert, Bor, Di Uccio, Fortunato Scotto, Parodi, Guido, Kedhi, Elvin, and Verdoia, Monica

Published
2021
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18. Impact of clinical and subclinical coronary artery disease as assessed by coronary artery calcium in COVID-19

Author

Scoccia, Alessandra, Gallone, Guglielmo, Cereda, Alberto, Palmisano, Anna, Vignale, Davide, Leone, Riccardo, Nicoletti, Valeria, Gnasso, Chiara, Monello, Alberto, Khokhar, Arif, Sticchi, Alessandro, Biagi, Andrea, Tacchetti, Carlo, Campo, Gianluca, Rapezzi, Claudio, Ponticelli, Francesco, Danzi, Gian Battista, Loffi, Marco, Pontone, Gianluca, Andreini, Daniele, Casella, Gianni, Iannopollo, Gianmarco, Ippolito, Davide, Bellani, Giacomo, Patelli, Gianluigi, Besana, Francesca, Costa, Claudia, Vignali, Luigi, Benatti, Giorgio, Iannaccone, Mario, Vaudano, Paolo Giacomo, Pacielli, Alberto, De Carlini, Caterina Chiara, Maggiolini, Stefano, Bonaffini, Pietro Andrea, Senni, Michele, Scarnecchia, Elisa, Anastasio, Fabio, Colombo, Antonio, Ferrari, Roberto, Esposito, Antonio, Giannini, Francesco, and Toselli, Marco

Published
2021
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19. Impact of renin-angiotensin system inhibitors on mortality during the COVID Pandemic among STEMI patients undergoing mechanical reperfusion: Insight from an international STEMI registry

Author

De Luca, Giuseppe, Cercek, Miha, Okkels Jensen, Lisette, Bushljetikj, Oliver, Calmac, Lucian, Johnson, Tom, Gracida Blancas, Montserrat, Ganyukov, Vladimir, Wojakowski, Wojtek, von Birgelen, Clemens, IJsselmuiden, Alexander, Tuccillo, Bernardo, Versaci, Francesco, Ten Berg, Jurrien, Laine, Mika, Berkout, Tim, Casella, Gianni, Kala, Petr, López Ledesma, Bernabé, Becerra, Victor, Padalino, Roberto, Santucci, Andrea, Carrillo, Xavier, Scoccia, Alessandra, Amoroso, Giovanni, Lux, Arpad, Kovarnik, Tomas, Davlouros, Periklis, Gabrielli, Gabriele, Flores Rios, Xacobe, Bakraceski, Nikola, Levesque, Sébastien, Guiducci, Vincenzo, Kidawa, Michał, Marinucci, Lucia, Zilio, Filippo, Galasso, Gennaro, Fabris, Enrico, Menichelli, Maurizio, Manzo, Stephane, Caiazzo, Gianluca, Moreu, Jose, Sanchis Forés, Juan, Donazzan, Luca, Vignali, Luigi, Teles, Rui, Agostoni, Pierfrancesco, Bosa Ojeda, Francisco, Lehtola, Heidi, Camacho-Freiere, Santiago, Kraaijeveld, Adriaan, Antti, Ylitalo, Visconti, Gabriella, Lozano Martínez-Luengas, Iñigo, Scheller, Bruno, Alexopulos, Dimitrios, Moreno, Raul, Kedhi, Elvin, Uccello, Giuseppe, Faurie, Benjamin, Gutierrez Barrios, Alejandro, Scotto Di Uccio, Fortunato, Wilbert, Bor, Cortese, Giuliana, Dirksen, Maurits T., Parodi, Guido, and Verdoia, Monica

Published
2021
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21. TCT-321 FFR-Guided PCI Optimization Directed by High-Definition IVUS Versus Standard of Care: 3-Year Results From the FFR REACT Trial

Author

Daemen, Joost, primary, Neleman, Tara, additional, Ziedses des Plantes, Anniek, additional, Groenland, Frederik, additional, Scoccia, Alessandra, additional, Van Zandvoort, Laurens, additional, Ligthart, Jurgen, additional, Witberg, Karen, additional, Lenzen, Mattie, additional, Cummins, Paul, additional, Boersma, Eric, additional, Nuis, Rutger-Jan, additional, Den Dekker, Wijnand, additional, Diletti, Roberto, additional, and Van Mieghem, Nicolas, additional

Published
2023
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22. TCT-553 Diagnostic Accuracy of AI-Enabled Ultrasonic Flow Ratio to Predict Post-PCI Fractional Flow Reserve: A Post Hoc Analysis of the FFR REACT Trial

Author

Scoccia, Alessandra, primary, Ziedses des Plantes, Anniek, additional, Neleman, Tara, additional, Kardys, Isabella, additional, Nuis, Rutger-Jan, additional, Den Dekker, Wijnand, additional, Diletti, Roberto, additional, Van Mieghem, Nicolas, additional, Tu, Shengxian, additional, Spitzer, Ernest, additional, and Daemen, Joost, additional

Published
2023
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23. TCT-93 Association Between Post-PCI vFFR and OCT Findings: Results From the FAST OCT Study

Author

Daemen, Joost, primary, Ziedses des Plantes, Anniek, additional, Scoccia, Alessandra, additional, Groenland, Frederik, additional, Forero, Maria Tovar, additional, Tomaniak, Mariusz, additional, Kochman, Janusz, additional, Wojakowski, Wojtek, additional, Ameloot, Koen, additional, Adriaenssens, Tom, additional, Dekker, Wijnand den, additional, Nuis, Rutger-Jan, additional, Kardys, Isabella, additional, van Mieghem, Nicolas, additional, and Spitzer, Ernest, additional

Published
2023
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25. Long Stent Implantation on the Left Anterior Descending Coronary Artery at a Follow-Up of More Than Five Years.

Author

Sticchi, Alessandro, Tatali, Concetta, Ferraro, Massimo, Khokhar, Arif A., Scoccia, Alessandra, Cereda, Alberto, Toselli, Marco, Gallo, Francesco, Laricchia, Alessandra, Mangieri, Antonio, Grigioni, Francesco, Ussia, Gian Paolo, Giannini, Francesco, and Colombo, Antonio

Subjects
CORONARY arteries, MYOCARDIAL infarction, PERCUTANEOUS coronary intervention, CARDIOVASCULAR disease related mortality
Abstract

Background: Stent implantation represents the standard of care in coronary intervention. While a short stent implanted on a focal lesion located on the left anterior descending artery (LAD) seems a reasonable alternative to an internal mammary implant, the same for long stents is still debated. Methods: We reported the long-term data of 531 consecutive patients who underwent Percutaneous Coronary Intervention (PCI) with long stents in two highly specialized centres. The main inclusion criteria were the implantation of stents longer than 30 mm on the LAD and a minimum follow-up (FU) of five years. The primary endpoint was mortality, and the secondary endpoints were any myocardial infarction (MI), target vessel and lesion revascularization (TVR and TLR, respectively), and stent thrombosis (ST) observed as definite, probable, or possible. Results: In this selected population with characteristics of complex PCI (99.1%), the long-term follow-up (mean 92.18 ± 35.5 months) estimates of all-cause death, cardiovascular death, and any myocardial infarction were 18.3%, 10.5%, and 9.3%, respectively. Both all-cause and cardiovascular deaths are significantly associated with three-vessel disease (HR 6.8; confidence of interval (CI) 95% 3.844–11.934; p < 0.001, and HR 4.7; CI 95% 2.265–9.835; p < 0.001, respectively). Target lesion (TLR) and target vessel revascularization (TVR) are associated with the presence of three-lesion disease on the LAD (HR 3.4; CI 95% 1.984–5.781; p < 0.001; HR 3.9 CI 95% 2.323–6.442; p < 0.001, respectively). Re-PCI for any cause occurred in 31.5% of patients and shows an increased risk for three-lesion stenting (HR 4.3; CI 95% 2.873–6.376; p < 0.001) and the treatment of bifurcation with two stents (HR 1.6; 95% CI 1.051–2.414; p = 0.028). Stent thrombosis rate at the 5-year FU was 4.4% (1.3% definite; 0.9% probable; 2.1% possible), including a 1.7% rate of very-late thrombosis. The stent length superior to 40 mm was not associated with poor outcomes (all-cause death p = 0.349; cardiovascular death p = 0.855; MI p = 0.691; re-PCI p = 0.234; TLR p = 0.805; TVR p = 0.087; ST p = 0.189). Conclusion: At an FU of longer than five years, patients treated with stents longer than 30 mm in their LAD showed acceptable procedural results but poor outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Impact of COVID-19 pandemic and diabetes on mechanical reperfusion in patients with STEMI: insights from the ISACS STEMI COVID 19 Registry

Author

De Luca, Giuseppe, Cercek, Miha, Jensen, Lisette Okkels, Vavlukis, Marija, Calmac, Lucian, Johnson, Tom, Roura i Ferrer, Gerard, Ganyukov, Vladimir, Wojakowski, Wojtek, von Birgelen, Clemens, Versaci, Francesco, Ten Berg, Jurrien, Laine, Mika, Dirksen, Maurits, Casella, Gianni, Kala, Petr, Díez Gil, José Luis, Becerra, Victor, De Simone, Ciro, Carrill, Xavier, Scoccia, Alessandra, Lux, Arpad, Kovarnik, Tomas, Davlouros, Periklis, Gabrielli, Gabriele, Flores Rios, Xacobe, Bakraceski, Nikola, Levesque, Sébastien, Guiducci, Vincenzo, Kidawa, Michał, Marinucci, Lucia, Zilio, Filippo, Galasso, Gennaro, Fabris, Enrico, Menichelli, Maurizio, Manzo, Stephane, Caiazzo, Gianluca, Moreu, Jose, Sanchis Forés, Juan, Donazzan, Luca, Vignali, Luigi, Teles, Rui, Bosa Ojeda, Francisco, Lehtola, Heidi, Camacho-Freiere, Santiago, Kraaijeveld, Adriaan, Antti, Ylitalo, Boccalatte, Marco, Martínez-Luengas, Iñigo Lozano, Scheller, Bruno, Alexopoulos, Dimitrios, Uccello, Giuseppe, Faurie, Benjamin, Gutierrez Barrios, Alejandro, Wilbert, Bor, Cortese, Giuliana, Moreno, Raul, Parodi, Guido, Kedhi, Elvin, and Verdoia, Monica

Published
2020
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27. Culprit lesion plaque characterization and thrombus grading by high‐definition intravascular ultrasound in patients with ST‐segment elevation myocardial infarction

Author

Groenland, Frederik T. W., primary, Ziedses des Plantes, Annemieke C., additional, Neleman, Tara, additional, Scoccia, Alessandra, additional, Ligthart, Jurgen M. R., additional, Witberg, Karen T., additional, Mahmoud, Karim D., additional, Nuis, Rutger‐Jan, additional, den Dekker, Wijnand K., additional, Wilschut, Jeroen M., additional, Diletti, Roberto, additional, Zijlstra, Felix, additional, Van Mieghem, Nicolas M., additional, and Daemen, Joost, additional

Published
2023
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28. Optical coherence tomography‐derived predictors of stent expansion in calcified lesions

Author

Ziedses des Plantes, Annemieke C., primary, Scoccia, Alessandra, additional, Neleman, Tara, additional, Groenland, Frederik T. W., additional, van Zandvoort, Laurens J. C., additional, Ligthart, Jurgen M. R., additional, Witberg, Karen T., additional, Liu, Shengnan, additional, Boersma, Eric, additional, Nuis, Rutger‐Jan, additional, den Dekker, Wijnand K., additional, Wilschut, Jeroen, additional, Diletti, Roberto, additional, Zijlstra, Felix, additional, Van Mieghem, Nicolas M., additional, and Daemen, Joost, additional

Published
2023
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29. Changes in post-PCI optimisation strategies with post-procedural FFR followed by IVUS

Author

Neleman, Tara, primary, Groenland, Frederik T. W., additional, Ziedses des Plantes, Annemieke C., additional, Scoccia, Alessandra, additional, van Zandvoort, Laurens J.C., additional, Boersma, Eric, additional, Nuis, Rutger-Jan, additional, den Dekker, Wijnand K., additional, Diletti, Roberto, additional, Wilschut, Jeroen, additional, Zijlstra, Felix, additional, Van Mieghem, Nicolas M., additional, and Daemen, Joost, additional

Published
2023
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31. Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry

Author

De Luca, Giuseppe, primary, Algowhary, Magdy, additional, Uguz, Berat, additional, Oliveira, Dinaldo C., additional, Ganyukov, Vladimir, additional, Busljetik, Oliver, additional, Cercek, Miha, additional, Jensen, Lisette Okkels, additional, Loh, Poay Huan, additional, Calmac, Lucian, additional, Ferrer, Gerard Roura i, additional, Quadros, Alexandre, additional, Milewski, Marek, additional, Scotto D’Uccio, Fortunato, additional, von Birgelen, Clemens, additional, Versaci, Francesco, additional, Ten Berg, Jurrien, additional, Casella, Gianni, additional, Wong Sung Lung, Aaron, additional, Kala, Petr, additional, Díez Gil, José Luis, additional, Carrillo, Xavier, additional, Dirksen, Maurits, additional, Becerra Munoz, Victor, additional, Lee, Michael Kang-yin, additional, Juzar, Dafsah Arifa, additional, de Moura Joaquim, Rodrigo, additional, Paladino, Roberto, additional, Milicic, Davor, additional, Davlouros, Periklis, additional, Bakraceski, Nikola, additional, Zilio, Filippo, additional, Donazzan, Luca, additional, Kraaijeveld, Adriaan, additional, Galasso, Gennaro, additional, Arpad, Lux, additional, Marinucci, Lucia, additional, Guiducci, Vincenzo, additional, Menichelli, Maurizio, additional, Scoccia, Alessandra, additional, Yamac, Aylin Hatice, additional, Ugur Mert, Kadir, additional, Flores Rios, Xacobe, additional, Kovarnik, Tomas, additional, Kidawa, Michal, additional, Moreu, Josè, additional, Flavien, Vincent, additional, Fabris, Enrico, additional, Martínez-Luengas, Iñigo Lozano, additional, Boccalatte, Marco, additional, Bosa Ojeda, Francisco, additional, Arellano-Serrano, Carlos, additional, Caiazzo, Gianluca, additional, Cirrincione, Giuseppe, additional, Kao, Hsien-Li, additional, Sanchis Forés, Juan, additional, Vignali, Luigi, additional, Pereira, Helder, additional, Manzo-Silberman, Stephane, additional, Ordoñez, Santiago, additional, Arat Özkan, Alev, additional, Scheller, Bruno, additional, Lehitola, Heidi, additional, Teles, Rui, additional, Mantis, Christos, additional, Antti, Ylitalo, additional, Brum Silveira, João António, additional, Zoni, Cesar Rodrigo, additional, Bessonov, Ivan, additional, Uccello, Giuseppe, additional, Kochiadakis, George, additional, Alexopulos, Dimitrios, additional, Uribe, Carlos E., additional, Kanakakis, John, additional, Faurie, Benjamin, additional, Gabrielli, Gabriele, additional, Gutierrez Barrios, Alejandro, additional, Bachini, Juan Pablo, additional, Rocha, Alex, additional, Tam, Frankie C. C., additional, Rodriguez, Alfredo, additional, Lukito, Antonia Anna, additional, Saint-Joy, Veauthyelau, additional, Pessah, Gustavo, additional, Tuccillo, Andrea, additional, Ielasi, Alfonso, additional, Cortese, Giuliana, additional, Parodi, Guido, additional, Burgadha, Mohammed Abed, additional, Kedhi, Elvin, additional, Lamelas, Pablo, additional, Suryapranata, Harry, additional, Nardin, Matteo, additional, and Verdoia, Monica, additional

Published
2023
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33. INTRAVASCULAR ULTRASOUND-BASED CULPRIT LESION PLAQUE CHARACTERIZATION AND THROMBUS ASSESSMENT IN PATIENTS PRESENTING WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION

Author

Groenland, Frederik T.W., primary, Neleman, Tara, additional, Plantes, Anniek Ziedses Des, additional, Scoccia, Alessandra, additional, Ligthart, Jurgen M.R., additional, Witberg, Karen Theodora, additional, Mahmoud, Karim D., additional, Nuis, Rutger-Jan, additional, Dekker, Wijnand Den, additional, Wilschut, Jeroen, additional, Diletti, Roberto, additional, Zijlstra, Felix, additional, Van Mieghem, Nicolas M., additional, and Daemen, Joost, additional

Published
2023
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34. NONCULPRIT LESION RECLASSIFICATION BASED ON VESSEL FRACTIONAL FLOW RESERVE IN PATIENTS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION: IMPACT ON TREATMENT STRATEGY AND CLINICAL OUTCOME (FAST STEMI I STUDY)

Author

Groenland, Frederik T.W., primary, Huang, Jager, additional, Scoccia, Alessandra, additional, Neleman, Tara, additional, Plantes, Anniek Ziedses Des, additional, Nuis, Rutger-Jan, additional, Den Dekker, Wijnand, additional, Wilschut, Jeroen, additional, Diletti, Roberto, additional, Kardys, Isabella, additional, Van Mieghem, Nicolas M., additional, and Daemen, Joost, additional

Published
2023
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35. Clinical Outcome of FFR-Guided Revascularization Strategy of Coronary Lesions: The HALE-BOPP Study

Author

Tebaldi, Matteo, primary, Gallo, Francesco, primary, Scoccia, Alessandra, primary, Durante, Alessandro, primary, Tedeschi, Delio, primary, Verdoliva, Sebastiano, primary, Cortese, Bernardo, primary, Bilotta, Ferruccio, primary, Watkins, Stuart, primary, Ielasi, Alfonso, primary, Valentini, Giuliano, primary, Pavasini, Rita, primary, Serenelli, Matteo, primary, D’Aniello, Emanuele, primary, Arena, Marco, primary, Pompei, Graziella, primary, Scala, Antonella, primary, Scollo, Ennio, primary, Gibiino, Federico, primary, Caglioni, Serena, primary, Mele, Daniela, primary, Marrone, Andrea, primary, Biscaglia, Simone, primary, Barbato, Emanuele, primary, and Campo, Gianluca, primary

Published
2023
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36. Gender Difference in the Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry

Author

De Luca, Giuseppe, primary, Manzo-Silberman, Stephane, additional, Algowhary, Magdy, additional, Uguz, Berat, additional, Oliveira, Dinaldo C., additional, Ganyukov, Vladimir, additional, Busljetik, Oliver, additional, Cercek, Miha, additional, Okkels, Lisette, additional, Loh, Poay Huan, additional, Calmac, Lucian, additional, Ferrer, Gerard Roura i, additional, Quadros, Alexandre, additional, Milewski, Marek, additional, Scotto di Uccio, Fortunato, additional, von Birgelen, Clemens, additional, Versaci, Francesco, additional, Ten Berg, Jurrien, additional, Casella, Gianni, additional, Wong Sung Lung, Aaron, additional, Kala, Petr, additional, Díez Gil, José Luis, additional, Carrillo, Xavier, additional, Dirksen, Maurits, additional, Becerra, Victor, additional, Lee, Michael Kang-yin, additional, Juzar, Dafsah Arifa, additional, de Moura Joaquim, Rodrigo, additional, Paladino, Roberto, additional, Milicic, Davor, additional, Davlouros, Periklis, additional, Bakraceski, Nikola, additional, Zilio, Filippo, additional, Donazzan, Luca, additional, Kraaijeveld, Adriaan, additional, Galasso, Gennaro, additional, Arpad, Lux, additional, Marinucci, Lucia, additional, Guiducci, Vincenzo, additional, Menichelli, Maurizio, additional, Scoccia, Alessandra, additional, Yamac, Aylin Hatice, additional, Ugur Mert, Kadir, additional, Flores Rios, Xacobe, additional, Kovarnik, Tomas, additional, Kidawa, Michal, additional, Moreu, Josè, additional, Flavien, Vincent, additional, Fabris, Enrico, additional, Martínez-Luengas, Iñigo Lozano, additional, Boccalatte, Marco, additional, Ojeda, Francisco Bosa, additional, Arellano-Serrano, Carlos, additional, Caiazzo, Gianluca, additional, Cirrincione, Giuseppe, additional, Kao, Hsien-Li, additional, Forés, Juan Sanchis, additional, Vignali, Luigi, additional, Pereira, Helder, additional, Ordoñez, Santiago, additional, Arat Özkan, Alev, additional, Scheller, Bruno, additional, Lehtola, Heidi, additional, Teles, Rui, additional, Mantis, Christos, additional, Antti, Ylitalo, additional, Brum Silveira, João António, additional, Zoni, Cesar Rodrigo, additional, Bessonov, Ivan, additional, Uccello, Giuseppe, additional, Kochiadakis, George, additional, Alexopulos, Dimitrios, additional, Uribe, Carlos E., additional, Kanakakis, John, additional, Faurie, Benjamin, additional, Gabrielli, Gabriele, additional, Barrios, Alejandro Gutierrez, additional, Bachini, Juan Pablo, additional, Rocha, Alex, additional, Tam, Frankie C. C., additional, Rodriguez, Alfredo, additional, Lukito, Antonia Anna, additional, Saint-Joy, Veauthyelau, additional, Pessah, Gustavo, additional, Tuccillo, Andrea, additional, Ielasi, Alfonso, additional, Cortese, Giuliana, additional, Parodi, Guido, additional, Bouraghda, Mohamed Abed, additional, Moura, Marcia, additional, Kedhi, Elvin, additional, Lamelas, Pablo, additional, Suryapranata, Harry, additional, Nardin, Matteo, additional, and Verdoia, Monica, additional

Published
2023
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37. Results of the ISACS-STEMI COVID-19 Registry

Author

De Luca, Giuseppe, Algowhary, Magdy, Uguz, Berat, Oliveira, Dinaldo C., Ganyukov, Vladimir, Busljetik, Oliver, Cercek, Miha, Jensen, Lisette Okkels, Loh, Poay Huan, Calmac, Lucian, Ferrer, Gerard Roura i., Quadros, Alexandre, Milewski, Marek, Scotto D’Uccio, Fortunato, von Birgelen, Clemens, Versaci, Francesco, Ten Berg, Jurrien, Casella, Gianni, Wong Sung Lung, Aaron, Kala, Petr, Díez Gil, José Luis, Carrillo, Xavier, Dirksen, Maurits, Becerra Munoz, Victor, Lee, Michael Kang yin, Juzar, Dafsah Arifa, de Moura Joaquim, Rodrigo, Paladino, Roberto, Milicic, Davor, Davlouros, Periklis, Bakraceski, Nikola, Zilio, Filippo, Donazzan, Luca, Kraaijeveld, Adriaan, Galasso, Gennaro, Arpad, Lux, Marinucci, Lucia, Guiducci, Vincenzo, Menichelli, Maurizio, Scoccia, Alessandra, Yamac, Aylin Hatice, Ugur Mert, Kadir, Flores Rios, Xacobe, Kovarnik, Tomas, Kidawa, Michal, Moreu, Josè, Flavien, Vincent, Fabris, Enrico, Martínez-Luengas, Iñigo Lozano, Boccalatte, Marco, Bosa Ojeda, Francisco, Arellano-Serrano, Carlos, Caiazzo, Gianluca, Cirrincione, Giuseppe, Kao, Hsien Li, Sanchis Forés, Juan, Vignali, Luigi, Pereira, Helder, Manzo-Silberman, Stephane, Ordoñez, Santiago, Arat Özkan, Alev, Scheller, Bruno, Lehitola, Heidi, Teles, Rui, Mantis, Christos, Antti, Ylitalo, Brum Silveira, João António, Zoni, Cesar Rodrigo, Bessonov, Ivan, Uccello, Giuseppe, Kochiadakis, George, Alexopulos, Dimitrios, Uribe, Carlos E., Kanakakis, John, Faurie, Benjamin, Gabrielli, Gabriele, Gutierrez Barrios, Alejandro, Bachini, Juan Pablo, Rocha, Alex, Tam, Frankie C.C., Rodriguez, Alfredo, Lukito, Antonia Anna, Saint-Joy, Veauthyelau, Pessah, Gustavo, Tuccillo, Andrea, Ielasi, Alfonso, Cortese, Giuliana, Parodi, Guido, Burgadha, Mohammed Abed, Kedhi, Elvin, Lamelas, Pablo, Suryapranata, Harry, Nardin, Matteo, Verdoia, Monica, and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Subjects
ST-segment elevation myocardial infarction, Medicine(all), ageing, COVID-19
Abstract

Background: The constraints in the management of patients with ST-segment elevation myocardial infarction (STEMI) during the COVID-19 pandemic have been suggested to have severely impacted mortality levels. The aim of the current analysis is to evaluate the age-related effects of the COVID-19 pandemic on mechanical reperfusion and 30-day mortality for STEMI within the registry ISACS-STEMI COVID-19. Methods: This retrospective multicenter registry was performed in high-volume PPCI centers on four continents and included STEMI patients undergoing PPCI in March–June 2019 and 2020. Patients were divided according to age (< or ≥75 years). The main outcomes were the incidence and timing of PPCI, (ischemia time longer than 12 h and door-to-balloon longer than 30 min), and in-hospital or 30-day mortality. Results: We included 16,683 patients undergoing PPCI in 109 centers. In 2020, during the pandemic, there was a significant reduction in PPCI as compared to 2019 (IRR 0.843 (95%-CI: 0.825–0.861, p < 0.0001). We found a significant age-related reduction (7%, p = 0.015), with a larger effect on elderly than on younger patients. Furthermore, we observed significantly higher 30-day mortality during the pandemic period, especially among the elderly (13.6% vs. 17.9%, adjusted HR (95% CI) = 1.55 [1.24–1.93], p < 0.001) as compared to younger patients (4.8% vs. 5.7%; adjusted HR (95% CI) = 1.25 [1.05–1.49], p = 0.013), as a potential consequence of the significantly longer ischemia time observed during the pandemic. Conclusions: The COVID-19 pandemic had a significant impact on the treatment of patients with STEMI, with a 16% reduction in PPCI procedures, with a larger reduction and a longer delay to treatment among elderly patients, which may have contributed to increase in-hospital and 30-day mortality during the pandemic. publishersversion published

Published
2023

38. Gender Difference in the Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI

Author

De Luca, Giuseppe, Manzo-Silberman, Stephane, Algowhary, Magdy, Uguz, Berat, Oliveira, Dinaldo C., Ganyukov, Vladimir, Busljetik, Oliver, Cercek, Miha, Okkels, Lisette, Loh, Poay Huan, Calmac, Lucian, Ferrer, Gerard Roura i., Quadros, Alexandre, Milewski, Marek, Scotto di Uccio, Fortunato, von Birgelen, Clemens, Versaci, Francesco, Ten Berg, Jurrien, Casella, Gianni, Wong Sung Lung, Aaron, Kala, Petr, Díez Gil, José Luis, Carrillo, Xavier, Dirksen, Maurits, Becerra, Victor, Lee, Michael Kang yin, Juzar, Dafsah Arifa, de Moura Joaquim, Rodrigo, Paladino, Roberto, Milicic, Davor, Davlouros, Periklis, Bakraceski, Nikola, Zilio, Filippo, Donazzan, Luca, Kraaijeveld, Adriaan, Galasso, Gennaro, Arpad, Lux, Marinucci, Lucia, Guiducci, Vincenzo, Menichelli, Maurizio, Scoccia, Alessandra, Yamac, Aylin Hatice, Ugur Mert, Kadir, Flores Rios, Xacobe, Kovarnik, Tomas, Kidawa, Michal, Moreu, Josè, Flavien, Vincent, Fabris, Enrico, Martínez-Luengas, Iñigo Lozano, Boccalatte, Marco, Ojeda, Francisco Bosa, Arellano-Serrano, Carlos, Caiazzo, Gianluca, Cirrincione, Giuseppe, Kao, Hsien Li, Forés, Juan Sanchis, Vignali, Luigi, Pereira, Helder, Ordoñez, Santiago, Arat Özkan, Alev, Scheller, Bruno, Lehtola, Heidi, Teles, Rui, Mantis, Christos, Antti, Ylitalo, Brum Silveira, João António, Zoni, Cesar Rodrigo, Bessonov, Ivan, Uccello, Giuseppe, Kochiadakis, George, Alexopulos, Dimitrios, Uribe, Carlos E., Kanakakis, John, Faurie, Benjamin, Gabrielli, Gabriele, Barrios, Alejandro Gutierrez, Bachini, Juan Pablo, Rocha, Alex, Tam, Frankie C.C., Rodriguez, Alfredo, Lukito, Antonia Anna, Saint-Joy, Veauthyelau, Pessah, Gustavo, Tuccillo, Andrea, Ielasi, Alfonso, Cortese, Giuliana, Parodi, Guido, Bouraghda, Mohamed Abed, Moura, Marcia, Kedhi, Elvin, Lamelas, Pablo, Suryapranata, Harry, Nardin, Matteo, Verdoia, Monica, NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), and Centro de Estudos de Doenças Crónicas (CEDOC)

Subjects
ST-segment elevation myocardial infarction, Medicine(all), percutaneous coronary intervention, gender, COVID-19
Abstract

Publisher Copyright: © 2023 by the authors. Background. Several reports have demonstrated the impact of the COVID-19 pandemic on the management and outcome of patients with ST-segment elevation myocardial infarction (STEMI). The aim of the current analysis is to investigate the potential gender difference in the effects of the COVID-19 pandemic on mechanical reperfusion and 30-day mortality for STEMI patients within the ISACS-STEMI COVID-19 Registry. Methods. This retrospective multicenter registry was performed in high-volume primary percutaneous coronary intervention (PPCI) centers on four continents and included STEMI patients undergoing PPCIs in March–June 2019 and 2020. Patients were divided according to gender. The main outcomes were the incidence and timing of the PPCI, (ischemia time ≥ 12 h and door-to-balloon ≥ 30 min) and in-hospital or 30-day mortality. Results. We included 16683 STEMI patients undergoing PPCIs in 109 centers. In 2020 during the pandemic, there was a significant reduction in PPCIs compared to 2019 (IRR 0.843 (95% CI: 0.825–0.861, p < 0.0001). We did not find a significant gender difference in the effects of the COVID-19 pandemic on the numbers of STEMI patients, which were similarly reduced from 2019 to 2020 in both groups, or in the mortality rates. Compared to prepandemia, 30-day mortality was significantly higher during the pandemic period among female (12.1% vs. 8.7%; adjusted HR [95% CI] = 1.66 [1.31–2.11], p < 0.001) but not male patients (5.8% vs. 6.7%; adjusted HR [95% CI] = 1.14 [0.96–1.34], p = 0.12). Conclusions. The COVID-19 pandemic had a significant impact on the treatment of patients with STEMI, with a 16% reduction in PPCI procedures similarly observed in both genders. Furthermore, we observed significantly increased in-hospital and 30-day mortality rates during the pandemic only among females. Trial registration number: NCT 04412655. publishersversion published

Published
2023

39. Association Between 3D-Angiography Based Fractional Flow Reserve and Non-Invasive Myocardial Ischemia Testing: The FAST ISCHEMIA Study

Author

Scoccia, Alessandra, Neleman, Tara, Tomaniak, Mariusz, Küçük, I Tarik, Masdjedi, Kaneshka, Mahmoud, Karim D, Hirsch, Alexander, Kardys, Isabella, Van Mieghem, Nicolas M, Zijlstra, Felix, Daemen, Joost, Cardiology, and Radiology & Nuclear Medicine

Abstract

BACKGROUND: In order to facilitate fractional flow reserve (FFR)-guided lesion assessment, several 3-dimensional (3D)-angiography-based physiological indices have been recently validated. Thus far, limited data are available on the association of these indices with conventional forms of ischemia testing. AIM: The aim of the study was to determine the association between 3D-angiography-based vessel-FFR (vFFR) and myocardial ischemia as assessed by exercise electrocardiography (ECG) testing, dobutamine stress echocardiography, single photon emission computed tomography myocardial perfusion imaging (SPECTMPI), and stress cardiovascular magnetic resonance imaging (stress CMR). METHODS: FAST ISCHEMIA is a retrospective, single-center cohort study including patients who underwent non-invasive myocardial ischemia testing and subsequent coronary angiography (≤3 months). A total of 145 patients (340 vessels) were analyzed. The overall patient-based sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), positive likelihood ratio (LR+), and negative likelihood ratio (LR-) of vFFR ≤0.80 in any vessel for ischemia was 64% (95% confidence interval [CI], 53-74), 71% (95% CI, 54-84), 83% (95% CI, 72-91), 46% (95% CI, 33-60), 2.16 (95% CI, 1.25-3.74), and 0.52 (95% CI, 0.36-0.74), respectively. Multivariable logistic regression showed that vFFR ≤0.80 was significantly associated with ischemia on a patient level (odds ratio, 8.13; 95% CI, 2.51-30.06; P

Published
2023

40. 1140 CLINICAL OUTCOME OF FRACTIONAL FLOW RESERVE GUIDED REVASCULARIZATION STRATEGY OF CORONARY LESIONS: THE HALE-BOPP STUDY

Author

Caglioni, Serena, primary, Campo, Gianluca, additional, Gallo, Francesco, additional, Scoccia, Alessandra, additional, Durante, Alessandro, additional, Tedeschi, Delio, additional, Verdoliva, Sebastiano, additional, Cortese, Bernardo, additional, Bilotta, Ferruccio, additional, Watkins, Stuart, additional, Ielasi, Alfonso, additional, Valentini, Giuliano, additional, Arena, Marco, additional, Mele, Daniela, additional, Pavasini, Rita, additional, Serenelli, Matteo, additional, Pompei, Graziella, additional, Scala, Antonella, additional, Gibiino, Federico, additional, Scollo, Ennio, additional, D´aniello, Emanuele, additional, Biscaglia, Simone, additional, Barbato, Emanuele, additional, and Tebaldi, Matteo, additional

Published
2022
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41. Impact of Smoking Status on Mortality in STEMI Patients Undergoing Mechanical Reperfusion for STEMI: Insights from the ISACS–STEMI COVID-19 Registry

Author

De Luca, Giuseppe, primary, Algowhary, Magdy, additional, Uguz, Berat, additional, Oliveira, Dinaldo, additional, Ganyukov, Vladimir, additional, Zimbakov, Zan, additional, Cercek, Miha, additional, Jensen, Lisette, additional, Loh, Poay, additional, Calmac, Lucian, additional, Ferrer, Gerard, additional, Quadros, Alexandre, additional, Milewski, Marek, additional, Scotto D’Uccio, Fortunato, additional, von Birgelen, Clemens, additional, Versaci, Francesco, additional, Ten Berg, Jurrien, additional, Casella, Gianni, additional, Wong Sung Lung, Aaron, additional, Kala, Petr, additional, Díez Gil, José, additional, Carrillo, Xavier, additional, Dirksen, Maurits, additional, Becerra-Munoz, Victor, additional, Lee, Michael, additional, Juzar, Dafsah, additional, Joaquim, Rodrigo, additional, Paladino, Roberto, additional, Milicic, Davor, additional, Davlouros, Periklis, additional, Bakraceski, Nikola, additional, Zilio, Filippo, additional, Donazzan, Luca, additional, Kraaijeveld, Adriaan, additional, Galasso, Gennaro, additional, Arpad, Lux, additional, Lucia, Marinucci, additional, Vincenzo, Guiducci, additional, Menichelli, Maurizio, additional, Scoccia, Alessandra, additional, Yamac, Aylin, additional, Ugur Mert, Kadir, additional, Flores Rios, Xacobe, additional, Kovarnik, Tomas, additional, Kidawa, Michal, additional, Moreu, Josè, additional, Vincent, Flavien, additional, Fabris, Enrico, additional, Martínez-Luengas, Iñigo, additional, Boccalatte, Marco, additional, Bosa Ojeda, Francisco, additional, Arellano-Serrano, Carlos, additional, Caiazzo, Gianluca, additional, Cirrincione, Giuseppe, additional, Kao, Hsien-Li, additional, Sanchis Forés, Juan, additional, Vignali, Luigi, additional, Pereira, Helder, additional, Manzo, Stephane, additional, Ordoñez, Santiago, additional, Özkan, Alev, additional, Scheller, Bruno, additional, Lehtola, Heidi, additional, Teles, Rui, additional, Mantis, Christos, additional, Antti, Ylitalo, additional, Silveira, João, additional, Zoni, Rodrigo, additional, Bessonov, Ivan, additional, Savonitto, Stefano, additional, Kochiadakis, George, additional, Alexopulos, Dimitrios, additional, Uribe, Carlos, additional, Kanakakis, John, additional, Faurie, Benjamin, additional, Gabrielli, Gabriele, additional, Barrios, Alejandro, additional, Bachini, Juan, additional, Rocha, Alex, additional, Tam, Frankie, additional, Rodriguez, Alfredo, additional, Lukito, Antonia, additional, Saint-Joy, Veauthyelau, additional, Pessah, Gustavo, additional, Tuccillo, Andrea, additional, Cortese, Giuliana, additional, Parodi, Guido, additional, Bouraghda, Mohamed, additional, Kedhi, Elvin, additional, Lamelas, Pablo, additional, Suryapranata, Harry, additional, Nardin, Matteo, additional, and Verdoia, Monica, additional

Published
2022
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44. SARS-CoV-2 Positivity, Stent Thrombosis, and 30-day Mortality in STEMI Patients Undergoing Mechanical Reperfusion

Author

De Luca, Giuseppe, primary, Algowhary, Magdy, additional, Uguz, Berat, additional, Oliveira, Dinaldo C, additional, Ganyukov, Vladimir, additional, Zimbakov, Zan, additional, Cercek, Miha, additional, Okkels Jensen, Lisette, additional, Loh, Poay Huan, additional, Calmac, Lucian, additional, Roura i Ferrer, Gerard, additional, Quadros, Alexandre, additional, Milewski, Marek, additional, Scotto Di Uccio, Fortunato, additional, von Birgelen, Clemens, additional, Versaci, Francesco, additional, Ten Berg, Jurrien, additional, Casella, Gianni, additional, Wong Sung Lung, Aaron, additional, Kala, Petr, additional, Díez Gil, José Luis, additional, Carrillo, Xavier, additional, Dirksen, Maurits, additional, Becerra-Munoz, Victor M., additional, Kang-yin Lee, Michael, additional, Juzar, Dafsah Arifa, additional, de Moura Joaquim, Rodrigo, additional, De Simone, Ciro, additional, Milicic, Davor, additional, Davlouros, Periklis, additional, Bakraceski, Nikola, additional, Zilio, Filippo, additional, Donazzan, Luca, additional, Kraaijeveld, Adriaan, additional, Galasso, Gennaro, additional, Arpad, Lux, additional, Marinucci, Lucia, additional, Guiducci, Vincenzo, additional, Menichelli, Maurizio, additional, Scoccia, Alessandra, additional, Yamac, Aylin Hatice, additional, Ugur Mert, Kadir, additional, Flores Rios, Xacobe, additional, Kovarnik, Tomas, additional, Kidawa, Michal, additional, Moreu, Josè, additional, Flavien, Vincent, additional, Fabris, Enrico, additional, Lozano Martínez-Luengas, Iñigo, additional, Boccalatte, Marco, additional, Bosa Ojeda, Francisco, additional, Arellano-Serrano, Carlos, additional, Caiazzo, Gianluca, additional, Cirrincione, Giuseppe, additional, Kao, Hsien-Li, additional, Sanchis Forés, Juan, additional, Vignali, Luigi, additional, Pereira, Helder, additional, Manzo-Silbermann, Stephane, additional, Ordoñez, Santiago, additional, Arat Özkan, Alev, additional, Scheller, Bruno, additional, Lehtola, Heidi, additional, Teles, Rui, additional, Mantis, Christos, additional, Antti, Ylitalo, additional, Brum Silveira, João António, additional, Bessonov, Ivan, additional, Zoni, Rodrigo, additional, Savonitto, Stefano, additional, Kochiadakis, George, additional, Alexopoulos, Dimitrios, additional, Uribe, Carlos E, additional, Kanakakis, John, additional, Faurie, Benjamin, additional, Gabrielli, Gabriele, additional, Gutierrez Barrios, Alejandro, additional, Bachini, Juan Pablo, additional, Rocha, Alex, additional, Tam, Frankie Chor-Cheung, additional, Rodriguez, Alfredo, additional, Lukito, Antonia Anna, additional, Bellemain-Appaix, Anne, additional, Pessah, Gustavo, additional, Cortese, Giuliana, additional, Parodi, Guido, additional, Burgadha, Mohammed Abed, additional, Kedhi, Elvin, additional, Lamelas, Pablo, additional, Suryapranata, Harry, additional, Nardin, Matteo, additional, and Verdoia, Monica, additional

Published
2022
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46. Symptoms-to-emergency-call timing delay in acute coronary syndrome before and during COVID-19: independent predictors and their impact on mortality

Author

STICCHI, Alessandro, primary, COSTA, Francesco, additional, MUSCOLI, Saverio, additional, ZILIO, Filippo, additional, BUONO, Andrea, additional, RUGGIERO, Rossella, additional, SCOCCIA, Alessandra, additional, CARACCIOLO, Alessandro, additional, LICORDARI, Roberto, additional, CAMMALLERI, Valeria, additional, IACOVELLI, Fortunato, additional, LOFFI, Marco, additional, SCORDINO, Domenico, additional, FERRO, Jayme, additional, ROGNONI, Andrea, additional, NAVA, Stefano, additional, ALBANI, Stefano, additional, PAVANI, Marco, additional, COLAIORI, Iginio, additional, BENENATI, Stefano, additional, PESCETELLI, Fabio, additional, DE MARZO, Vincenzo, additional, BORGHESI, Marco, additional, REGAZZONI, Valentina, additional, MANNARINI, Antonia, additional, SPIONE, Francesco, additional, BALDASSARRE, Doronzo, additional, de BENEDICTIS, Michele, additional, BONMASSARI, Roberto, additional, DANZI, Gian Battista, additional, GALLI, Mario, additional, IELASI, Alfonso, additional, MUSUMECI, Giuseppe, additional, TOMAI, Fabrizio, additional, MICARI, Antonio, additional, PASCERI, Vincenzo, additional, PATTI, Giuseppe, additional, PORTO, Italo, additional, CAMPO, Gianluca, additional, COLOMBO, Antonio, additional, and GIANNINI, Francesco, additional

Published
2022
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47. Procedural Performance of Ultrathin, Biodegradable Polymer-Coated Stents Versus Durable Polymer-Coated Stents Based on Intracoronary Imaging

Author

Ziedses des Plantes, Annemieke C, Neleman, Tara, Tovar Forero, Maria N, Visser, Leon, Scoccia, Alessandra, Groenland, Frederik T W, Ligthart, Jurgen M R, Boersma, Eric, Nuis, Rutger-Jan, den Dekker, Wijnand K, Wilschut, Jeroen, Diletti, Roberto, Zijlstra, Felix, Van Mieghem, Nicolas M, Daemen, Joost, and Cardiology

Abstract

OBJECTIVE: Thinner stent struts might lead to a higher risk of recoil and subsequently a smaller minimal stent area (MSA), which is known to be the strongest predictor of stent failure. We compared procedural performance between an ultrathin-strut biodegradable-polymer sirolimus-eluting stent (BP-SES) and a durable-polymer zotarolimus-eluting stent (DP-ZES) using intracoronary imaging. METHODS: A consecutive cohort of patients underwent percutaneous coronary intervention (PCI) with either BP-SES or DP-ZES in a pseudorandomized fashion between July 2018 and October 2019. In the present subanalysis, we included cases in which post-PCI imaging with intravascular ultrasound (IVUS) or optical coherence tomography (OCT) was performed. The primary endpoint of the study was MSA. Secondary endpoints included percentage stent expansion and presence of residual edge disease, malapposition, tissue protrusion, submedial edge dissections, or edge hematoma. RESULTS: A total of 141 treated lesions (78 BP-SES and 63 DP-ZES) in 127 patients were analyzed. Median age was 69.3 years (interquartile range [IQR], 57.3-75.6) and 74.0% of patients were male. All baseline and procedural characteristics were comparable between both groups. Median MSA was 5.80 mm² (IQR, 4.40-7.24) for BP-SES and 6.35 mm² (IQR, 4.76-8.31) for DP-ZES (P=.15). No significant differences in stent expansion, residual edge disease and presence of malapposition, tissue protrusion, submedial edge dissections, or edge hematomas were found. Stent diameter and stent length were found to be independent predictors of MSA. CONCLUSIONS: No significant differences in MSA were found between lesions treated with BP-SES vs DP-ZES. BP-SES and DP-ZES were comparable in terms of procedural performance.

Published
2022

48. Impact of Smoking Status on Mortality in STEMI Patients Undergoing Mechanical Reperfusion for STEMI

Author

De Luca, Giuseppe, Algowhary, Magdy, Uguz, Berat, Oliveira, Dinaldo C., Ganyukov, Vladimir, Zimbakov, Zan, Cercek, Miha, Jensen, Lisette Okkels, Loh, Poay Huan, Calmac, Lucian, Ferrer, Gerard Roura i., Quadros, Alexandre, Milewski, Marek, Scotto D’Uccio, Fortunato, von Birgelen, Clemens, Versaci, Francesco, Ten Berg, Jurrien, Casella, Gianni, Wong Sung Lung, Aaron, Kala, Petr, Díez Gil, José Luis, Carrillo, Xavier, Dirksen, Maurits, Becerra-Munoz, Victor M., Lee, Michael Kang yin, Juzar, Dafsah Arifa, Joaquim, Rodrigo de Moura, Paladino, Roberto, Milicic, Davor, Davlouros, Periklis, Bakraceski, Nikola, Zilio, Filippo, Donazzan, Luca, Kraaijeveld, Adriaan, Galasso, Gennaro, Arpad, Lux, Lucia, Marinucci, Vincenzo, Guiducci, Menichelli, Maurizio, Scoccia, Alessandra, Yamac, Aylin Hatice, Ugur Mert, Kadir, Flores Rios, Xacobe, Kovarnik, Tomas, Kidawa, Michal, Moreu, Josè, Vincent, Flavien, Fabris, Enrico, Martínez-Luengas, Iñigo Lozano, Boccalatte, Marco, Bosa Ojeda, Francisco, Arellano-Serrano, Carlos, Caiazzo, Gianluca, Cirrincione, Giuseppe, Kao, Hsien Li, Sanchis Forés, Juan, Vignali, Luigi, Pereira, Helder, Manzo, Stephane, Ordoñez, Santiago, Özkan, Alev Arat, Scheller, Bruno, Lehtola, Heidi, Teles, Rui, Mantis, Christos, Antti, Ylitalo, Silveira, João António Brum, Zoni, Rodrigo, Bessonov, Ivan, Savonitto, Stefano, Kochiadakis, George, Alexopulos, Dimitrios, Uribe, Carlos E., Kanakakis, John, Faurie, Benjamin, Gabrielli, Gabriele, Barrios, Alejandro Gutierrez, Bachini, Juan Pablo, Rocha, Alex, Tam, Frankie Chor Cheung, Rodriguez, Alfredo, Lukito, Antonia Anna, Saint-Joy, Veauthyelau, Pessah, Gustavo, Tuccillo, Andrea, Cortese, Giuliana, Parodi, Guido, Bouraghda, Mohamed Abed, Kedhi, Elvin, Lamelas, Pablo, Suryapranata, Harry, Nardin, Matteo, Verdoia, Monica, and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Subjects
Medicine(all), myocardial infarction, percutaneous coronary intervention, COVID-19, smoking paradox
Abstract

Publisher Copyright: © 2022 by the authors. The so-called “smoking paradox”, conditioning lower mortality in smokers among STEMI patients, has seldom been addressed in the settings of modern primary PCI protocols. The ISACS–STEMI COVID-19 is a large-scale retrospective multicenter registry addressing in-hospital mortality, reperfusion, and 30-day mortality among primary PCI patients in the era of the COVID-19 pandemic. Among the 16,083 STEMI patients, 6819 (42.3%) patients were active smokers, 2099 (13.1%) previous smokers, and 7165 (44.6%) non-smokers. Despite the impaired preprocedural recanalization (p < 0.001), active smokers had a significantly better postprocedural TIMI flow compared with non-smokers (p < 0.001); this was confirmed after adjustment for all baseline and procedural confounders, and the propensity score. Active smokers had a significantly lower in-hospital (p < 0.001) and 30-day (p < 0.001) mortality compared with non-smokers and previous smokers; this was confirmed after adjustment for all baseline and procedural confounders, and the propensity score. In conclusion, in our population, active smoking was significantly associated with improved epicardial recanalization and lower in-hospital and 30-day mortality compared with previous and non-smoking history. publishersversion published

Published
2022

49. Impact of chronic obstructive pulmonary disease on short-term outcome in patients with ST-elevation myocardial infarction during COVID-19 pandemic

Author

De Luca, Giuseppe, Nardin, Matteo, Algowhary, Magdy, Uguz, Berat, Oliveira, Dinaldo C., Ganyukov, Vladimir, Zimbakov, Zan, Cercek, Miha, Okkels Jensen, Lisette, Loh, Poay Huan, Calmac, Lucian, Roura Ferrer, Gerard, Quadros, Alexandre, Milewski, Marek, Scotto di Uccio, Fortunato, von Birgelen, Clemens, Versaci, Francesco, Ten Berg, Jurrien, Casella, Gianni, Wong Sung Lung, Aaron, Kala, Petr, Díez Gil, José Luis, Carrillo, Xavier, Dirksen, Maurits, Becerra-Munoz, Victor M., Lee, Michael Kang Yin, Arifa Juzar, Dafsah, de Moura Joaquim, Rodrigo, Paladino, Roberto, Milicic, Davor, Davlouros, Periklis, Bakraceski, Nikola, Zilio, Filippo, Donazzan, Luca, Kraaijeveld, Adriaan, Galasso, Gennaro, Lux, Arpad, Marinucci, Lucia, Guiducci, Vincenzo, Menichelli, Maurizio, Scoccia, Alessandra, Yamac, Aylin Hatice, Ugur Mert, Kadir, Flores Rios, Xacobe, Kovarnik, Tomas, Kidawa, Michal, Moreu, Josè, Flavien, Vincent, Fabris, Enrico, Martínez-Luengas, Iñigo Lozano, Boccalatte, Marco, Bosa Ojeda, Francisco, Arellano-Serrano, Carlos, Caiazzo, Gianluca, Cirrincione, Giuseppe, Kao, Hsien Li, Sanchis Forés, Juan, Vignali, Luigi, Pereira, Helder, Manzo, Stephane, Ordoñez, Santiago, Özkan, Alev Arat, Scheller, Bruno, Lehtola, Heidi, Teles, Rui, Mantis, Christos, Antti, Ylitalo, Brum Silveira, João A., Zoni, Rodrigo, Bessonov, Ivan, Savonitto, Stefano, Kochiadakis, George, Alexopoulos, Dimitrios, Uribe, Carlos E., Kanakakis, John, Faurie, Benjamin, Gabrielli, Gabriele, Gutierrez Barrios, Alejandro, Bachini, Juan Pablo, Rocha, Alex, Tam, Frankie Chor Cheung, Rodriguez, Alfredo, Lukito, Antonia Anna, Saint-Joy, Veauthyelau, Pessah, Gustavo, Tuccillo, Andrea, Cortese, Giuliana, Parodi, Guido, Bouraghda, Mohamed Abed, Kedhi, Elvin, Lamelas, Pablo, Suryapranata, Harry, Verdoia, Monica, and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)

Subjects
STEMI, Pulmonary and Respiratory Medicine, SDG 3 - Good Health and Well-being, COPD, Mortality
Abstract

Publisher Copyright: © 2022. The Author(s). BACKGROUND: Chronic obstructive pulmonary disease (COPD) is projected to become the third cause of mortality worldwide. COPD shares several pathophysiological mechanisms with cardiovascular disease, especially atherosclerosis. However, no definite answers are available on the prognostic role of COPD in the setting of ST elevation myocardial infarction (STEMI), especially during COVID-19 pandemic, among patients undergoing primary angioplasty, that is therefore the aim of the current study. METHODS: In the ISACS-STEMI COVID-19 registry we included retrospectively patients with STEMI treated with primary percutaneous coronary intervention (PCI) between March and June of 2019 and 2020 from 109 high-volume primary PCI centers in 4 continents. RESULTS: A total of 15,686 patients were included in this analysis. Of them, 810 (5.2%) subjects had a COPD diagnosis. They were more often elderly and with a more pronounced cardiovascular risk profile. No preminent procedural dissimilarities were noticed except for a lower proportion of dual antiplatelet therapy at discharge among COPD patients (98.9% vs. 98.1%, P = 0.038). With regards to short-term fatal outcomes, both in-hospital and 30-days mortality occurred more frequently among COPD patients, similarly in pre-COVID-19 and COVID-19 era. However, after adjustment for main baseline differences, COPD did not result as independent predictor for in-hospital death (adjusted OR [95% CI] = 0.913[0.658-1.266], P = 0.585) nor for 30-days mortality (adjusted OR [95% CI] = 0.850 [0.620-1.164], P = 0.310). No significant differences were detected in terms of SARS-CoV-2 positivity between the two groups. CONCLUSION: This is one of the largest studies investigating characteristics and outcome of COPD patients with STEMI undergoing primary angioplasty, especially during COVID pandemic. COPD was associated with significantly higher rates of in-hospital and 30-days mortality. However, this association disappeared after adjustment for baseline characteristics. Furthermore, COPD did not significantly affect SARS-CoV-2 positivity. TRIAL REGISTRATION NUMBER: NCT04412655 (2nd June 2020). publishersversion published

Published
2022

50. Validation of Post-PCI FFR Gradients With IVUS-Detected Focal Lesions and Stent Underexpansion

Author

Neleman, Tara, primary, Scoccia, Alessandra, additional, van Zandvoort, Laurens J.C., additional, Ligthart, Jurgen M.R., additional, Witberg, Karen T., additional, Lenzen, Mattie J., additional, Boersma, Eric, additional, Nuis, Rutger-Jan, additional, den Dekker, Wijnand, additional, Diletti, Roberto, additional, Wilschut, Jeroen, additional, Zijlstra, Felix, additional, Van Mieghem, Nicolas M., additional, and Daemen, Joost, additional

Published
2022
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