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29 results on '"Sciscent, Bao Y."'

11. Current and Emerging Diagnostic, Prognostic, and Predictive Biomarkers in Head and Neck Cancer.

Author

Eberly, Hänel W., Sciscent, Bao Y., Lorenz, F. Jeffrey, Rettig, Eleni M., and Goyal, Neerav

Subjects
SQUAMOUS cell carcinoma, BIOMARKERS, HEAD & neck cancer, RADIOTHERAPY, ACUTE flaccid paralysis
Abstract

Head and neck cancers (HNC) are a biologically diverse set of cancers that are responsible for over 660,000 new diagnoses each year. Current therapies for HNC require a comprehensive, multimodal approach encompassing resection, radiation therapy, and systemic therapy. With an increased understanding of the mechanisms behind HNC, there has been growing interest in more accurate prognostic indicators of disease, effective post-treatment surveillance, and individualized treatments. This chapter will highlight the commonly used and studied biomarkers in head and neck squamous cell carcinoma. [ABSTRACT FROM AUTHOR]

Published
2024
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16. History of Bariatric Surgery Before Thyroid Surgery: Recommendations for Prevention and Management of Postoperative Hypocalcemia.

Author

Eberly, Hänel W., Sciscent, Bao Y., Jeffrey Lorenz, F., Goyal, Neerav, and Goldenberg, David

Abstract

Hypocalcemia following thyroidectomy is a common and potentially life‐threatening complication. It is caused by intraoperative injury to the parathyroid glands or their blood supply. Although several studies have shown that patients with a prior history of bariatric surgery may be at an increased risk for hypocalcemia after thyroidectomy, no clear recommendations exist for preventing and managing this condition in this population. This paper highlights the significance of understanding this risk and of obtaining a history of prior bariatric surgery before thyroidectomy. We propose concise recommendations for preventing and managing hypocalcemia following thyroidectomy in patients with a history of bariatric surgery. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Pregnancy and Childbirth in Women With Meningioma

Author

Hallan, David R, primary, Bhanja, Debarati, additional, Sciscent, Bao Y, additional, Ryan, Casey, additional, Gigliotti, Michael J, additional, Daggubati, Lekhaj C, additional, Caldwell, Catherine, additional, and Rizk, Elias, additional

Published
2022
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24. Deciphering the mechanism of O2 reduction with electronically tunable non-heme iron enzyme model complexes† †Electronic supplementary information (ESI) available. CCDC 1833291–1833295 and 1833299. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c8sc01621f

Author

Surendhran, Roshaan, D'Arpino, Alexander A., Sciscent, Bao Y., Cannella, Anthony F., Friedman, Alan E., MacMillan, Samantha N., Gupta, Rupal, and Lacy, David C.

Subjects
Chemistry
Abstract

A homologous series of electronically tuned ligands were prepared and some of their corresponding Fe complexes were prepared and a Hammett plot of the rates of O2 reduction allowed us to infer important details of the mechanism., A homologous series of electronically tuned 2,2′,2′′-nitrilotris(N-arylacetamide) pre-ligands (H3LR) were prepared (R = NO2, CN, CF3, F, Cl, Br, Et, Me, H, OMe, NMe2) and some of their corresponding Fe and Zn species synthesized. The iron complexes react rapidly with O2, the final products of which are diferric mu-oxo bridged species. The crystal structure of the oxidized product obtained from DMA solutions contain a structural motif found in some diiron proteins. The mechanism of iron mediated O2 reduction was explored to the extent that allowed us to construct an empirically consistent rate law. A Hammett plot was constructed that enabled insightful information into the rate-determining step and hence allows for a differentiation between two kinetically equivalent O2 reduction mechanisms.

Published
2018

25. The Role of Immunosuppression on Postoperative Outcomes in Facial Fracture Repair

Author

Eberly, Hänel W., Rothka, Andrew J., Sciscent, Bao Y., and Lighthall, Jessyka G.

Abstract

Objectives:To assess postoperative outcomes in immunosuppressed patients with facial fractures. Methods:TriNetX, a large de-identified health research database, was utilized to compare outcomes within 30 days of treatment between immunosuppressed and immunocompetent patients with facial fractures. Subgroup analysis was conducted based on use of immunosuppressive therapy, human immunodeficiency virus (HIV) status, diabetes, and chronic kidney disease (CKD). Results:Nine thousand four hundred seventy-five patients were identified. On subgroup analysis, 555 patients were on immunosuppressants, 429 patients had HIV, 619 patients had CKD, 1322 patients with liver disease, and 3133 had diabetes. Immunosuppressed patients more frequently experienced postoperative infections [odds ratio (OR) 1.37 (1.9-1.54), P< .001], thromboembolic events [OR 1.71 (1.33-2.20), P< .001], hemorrhage [OR 1.46 (1.10-1.92), P= .0087], hospital readmission [OR 1.36 (1.28-1.44), P< .001], subsequent emergency department encounters [OR 1.08 (1.01-1.15), P= .0249], and wound disruptions [OR 1.52 (1.17-1.97), P= .0017]. Analyses comparing outcomes by immunosuppression type found increased rates of infection [OR 1.59 (1.25-2.01), P< .001], thromboembolic events [OR 1.56 (1.07-2.26), P= .0196], wound disruption [OR 1.57 (1.03-2.39), P= .0357], and hospital readmission [OR 1.28 (1.16-1.42), P< .001] in diabetic patients. Patients with CKD [OR 1.7 (1-2.90), P= .0478] had higher rates of infection [OR 2.02 (1.18-3.46), P= .0092] and readmission [OR 1.43 (1.14-1.79), P= .0017]. Patients with liver disease had higher rates of infection [OR 1.54 (1.07-2.23), P= .0210], thromboembolic events [OR 2.84 (1.37-5.87), P= .0033], and readmission [OR 2.14 (1.83-2.51), P< .001]. No significant differences were seen between groups for HIV patients. Conclusions:Immunosuppressed patients with facial trauma have a higher prevalence of postoperative complications compared to immunocompetent patients. Diabetics had a higher prevalence of most complications while patients with CKD and liver disease had higher rates of infections. Surgeons may consider measures to decrease postoperative risk in these patients and to provide preoperative patient counseling.

Published
2024
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29. Deciphering the mechanism of O 2 reduction with electronically tunable non-heme iron enzyme model complexes.

Author

Surendhran R, D'Arpino AA, Sciscent BY, Cannella AF, Friedman AE, MacMillan SN, Gupta R, and Lacy DC

Abstract

A homologous series of electronically tuned 2,2 ' ,2 '' -nitrilotris( N -arylacetamide) pre-ligands ( H 3 L R ) were prepared (R = NO 2 , CN, CF 3 , F, Cl, Br, Et, Me, H, OMe, NMe 2 ) and some of their corresponding Fe and Zn species synthesized. The iron complexes react rapidly with O 2 , the final products of which are diferric mu-oxo bridged species. The crystal structure of the oxidized product obtained from DMA solutions contain a structural motif found in some diiron proteins. The mechanism of iron mediated O 2 reduction was explored to the extent that allowed us to construct an empirically consistent rate law. A Hammett plot was constructed that enabled insightful information into the rate-determining step and hence allows for a differentiation between two kinetically equivalent O 2 reduction mechanisms.

Published
2018
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