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3. Reliability assessment of ultrasound muscle echogenicity in patients with rheumatic diseases: Results of a multicenter international web-based study

Author

Di Matteo, A, Moscioni, E, Lommano, M, Cipolletta, E, Smerilli, G, Farah, S, Airoldi, C, Aydin, S, Becciolini, A, Bonfiglioli, K, Carotti, M, Carrara, G, Cazenave, T, Corradini, D, Cosatti, M, de Agustin, J, Destro Castaniti, G, Di Carlo, M, Di Donato, E, Di Geso, L, Elliott, A, Fodor, D, Francioso, F, Gabba, A, Hernandez-Diaz, C, Horvath, R, Hurnakova, J, Jesus, D, Marin, J, Martire, M, Mashadi Mirza, R, Massarotti, M, Musca, A, Nair, J, Okano, T, Papalopoulos, I, Rosa, J, Rosemffet, M, Rovisco, J, Rozza, D, Salaffi, F, Scioscia, C, Scire, C, Tamas, M, Tanimura, S, Ventura-Rios, L, Villota-Eraso, C, Villota, O, Voulgari, P, Vreju, F, Vukatana, G, Hereter, J, Zanetti, A, Grassi, W, Filippucci, E, Di Matteo A., Moscioni E., Lommano M. G., Cipolletta E., Smerilli G., Farah S., Airoldi C., Aydin S. Z., Becciolini A., Bonfiglioli K., Carotti M., Carrara G., Cazenave T., Corradini D., Cosatti M. A., de Agustin J. J., Destro Castaniti G. M., Di Carlo M., Di Donato E., Di Geso L., Elliott A., Fodor D., Francioso F., Gabba A., Hernandez-Diaz C., Horvath R., Hurnakova J., Jesus D., Marin J., Martire M. V., Mashadi Mirza R., Massarotti M., Musca A. A., Nair J., Okano T., Papalopoulos I., Rosa J., Rosemffet M., Rovisco J., Rozza D., Salaffi F., Scioscia C., Scire C. A., Tamas M. -M., Tanimura S., Ventura-Rios L., Villota-Eraso C., Villota O., Voulgari P. V., Vreju F. A., Vukatana G., Hereter J. Z., Zanetti A., Grassi W., Filippucci E., Di Matteo, A, Moscioni, E, Lommano, M, Cipolletta, E, Smerilli, G, Farah, S, Airoldi, C, Aydin, S, Becciolini, A, Bonfiglioli, K, Carotti, M, Carrara, G, Cazenave, T, Corradini, D, Cosatti, M, de Agustin, J, Destro Castaniti, G, Di Carlo, M, Di Donato, E, Di Geso, L, Elliott, A, Fodor, D, Francioso, F, Gabba, A, Hernandez-Diaz, C, Horvath, R, Hurnakova, J, Jesus, D, Marin, J, Martire, M, Mashadi Mirza, R, Massarotti, M, Musca, A, Nair, J, Okano, T, Papalopoulos, I, Rosa, J, Rosemffet, M, Rovisco, J, Rozza, D, Salaffi, F, Scioscia, C, Scire, C, Tamas, M, Tanimura, S, Ventura-Rios, L, Villota-Eraso, C, Villota, O, Voulgari, P, Vreju, F, Vukatana, G, Hereter, J, Zanetti, A, Grassi, W, Filippucci, E, Di Matteo A., Moscioni E., Lommano M. G., Cipolletta E., Smerilli G., Farah S., Airoldi C., Aydin S. Z., Becciolini A., Bonfiglioli K., Carotti M., Carrara G., Cazenave T., Corradini D., Cosatti M. A., de Agustin J. J., Destro Castaniti G. M., Di Carlo M., Di Donato E., Di Geso L., Elliott A., Fodor D., Francioso F., Gabba A., Hernandez-Diaz C., Horvath R., Hurnakova J., Jesus D., Marin J., Martire M. V., Mashadi Mirza R., Massarotti M., Musca A. A., Nair J., Okano T., Papalopoulos I., Rosa J., Rosemffet M., Rovisco J., Rozza D., Salaffi F., Scioscia C., Scire C. A., Tamas M. -M., Tanimura S., Ventura-Rios L., Villota-Eraso C., Villota O., Voulgari P. V., Vreju F. A., Vukatana G., Hereter J. Z., Zanetti A., Grassi W., and Filippucci E.

Abstract

Objectives: To investigate the inter/intra-reliability of ultrasound (US) muscle echogenicity in patients with rheumatic diseases. Methods: Forty-two rheumatologists and 2 radiologists from 13 countries were asked to assess US muscle echogenicity of quadriceps muscle in 80 static images and 20 clips from 64 patients with different rheumatic diseases and 8 healthy subjects. Two visual scales were evaluated, a visual semi-quantitative scale (0–3) and a continuous quantitative measurement (“VAS echogenicity,” 0–100). The same assessment was repeated to calculate intra-observer reliability. US muscle echogenicity was also calculated by an independent research assistant using a software for the analysis of scientific images (ImageJ). Inter and intra reliabilities were assessed by means of prevalence-adjusted bias-adjusted Kappa (PABAK), intraclass correlation coefficient (ICC) and correlations through Kendall’s Tau and Pearson’s Rho coefficients. Results: The semi-quantitative scale showed a moderate inter-reliability [PABAK = 0.58 (0.57–0.59)] and a substantial intra-reliability [PABAK = 0.71 (0.68–0.73)]. The lowest inter and intra-reliability results were obtained for the intermediate grades (i.e., grade 1 and 2) of the semi-quantitative scale. “VAS echogenicity” showed a high reliability both in the inter-observer [ICC = 0.80 (0.75–0.85)] and intra-observer [ICC = 0.88 (0.88–0.89)] evaluations. A substantial association was found between the participants assessment of the semi-quantitative scale and “VAS echogenicity” [ICC = 0.52 (0.50–0.54)]. The correlation between these two visual scales and ImageJ analysis was high (tau = 0.76 and rho = 0.89, respectively). Conclusion: The results of this large, multicenter study highlighted the overall good inter and intra-reliability of the US assessment of muscle echogenicity in patients with different rheumatic diseases.

Published
2023

4. Musculoskeletal ultrasound may narrow the gap between patients and physicians in the assessment of rheumatoid arthritis disease activity

Author

Floris, A, Rozza, D, Zanetti, A, Carrara, G, Bellis, E, Cauli, A, Iagnocco, A, Scire, C, Piga, M, Batticciotto, A, Bortoluzzi, A, Gabba, A, Gattamelata, A, Adinolfi, A, Raffeiner, B, Vinghitti, C, Mastaglio, C, Scioscia, C, Russi, D, Luccioli, F, Cavatorta, F, Ceccarelli, F, Sakellariou, G, Filippou, G, Cagnotto, G, Farina, I, Menza, L, Idolazzi, L, Canzoni, M, Massarotti, M, Focherini, M, Caprioli, M, Gutierrez, M, Draghessi, A, Muratore, M, De Lucia, O, Rossini, P, Macchioni, P, Ramonda, R, Rossi, S, Parisi, S, Sabatino, V, Picerno, V, Floris A., Rozza D., Zanetti A., Carrara G., Bellis E., Cauli A., Iagnocco A., Scire C. A., Piga M., Batticciotto A., Bortoluzzi A., Gabba A., Gattamelata A., Adinolfi A., Raffeiner B., Vinghitti C., Mastaglio C., Scioscia C., Russi D., Luccioli F., Cavatorta F., Ceccarelli F., Sakellariou G., Filippou G., Cagnotto G., Farina I., Menza L., Idolazzi L., Canzoni M., Massarotti M., Focherini M., Caprioli M., Gutierrez M., Draghessi A., Muratore M., De Lucia O., Rossini P., MacChioni P., Ramonda R., Rossi S., Parisi S., Sabatino V. D., Picerno V., Floris, A, Rozza, D, Zanetti, A, Carrara, G, Bellis, E, Cauli, A, Iagnocco, A, Scire, C, Piga, M, Batticciotto, A, Bortoluzzi, A, Gabba, A, Gattamelata, A, Adinolfi, A, Raffeiner, B, Vinghitti, C, Mastaglio, C, Scioscia, C, Russi, D, Luccioli, F, Cavatorta, F, Ceccarelli, F, Sakellariou, G, Filippou, G, Cagnotto, G, Farina, I, Menza, L, Idolazzi, L, Canzoni, M, Massarotti, M, Focherini, M, Caprioli, M, Gutierrez, M, Draghessi, A, Muratore, M, De Lucia, O, Rossini, P, Macchioni, P, Ramonda, R, Rossi, S, Parisi, S, Sabatino, V, Picerno, V, Floris A., Rozza D., Zanetti A., Carrara G., Bellis E., Cauli A., Iagnocco A., Scire C. A., Piga M., Batticciotto A., Bortoluzzi A., Gabba A., Gattamelata A., Adinolfi A., Raffeiner B., Vinghitti C., Mastaglio C., Scioscia C., Russi D., Luccioli F., Cavatorta F., Ceccarelli F., Sakellariou G., Filippou G., Cagnotto G., Farina I., Menza L., Idolazzi L., Canzoni M., Massarotti M., Focherini M., Caprioli M., Gutierrez M., Draghessi A., Muratore M., De Lucia O., Rossini P., MacChioni P., Ramonda R., Rossi S., Parisi S., Sabatino V. D., and Picerno V.

Abstract

Objectives: To investigate the association between patient-physician discordance in the assessment of disease activity and residual US synovitis/tenosynovitis in a cohort of patients with RA in clinical remission. Methods: A post hoc analysis of the STARTER study, promoted by the Musculoskeletal-US (MSUS) Study Group of the Italian Society for Rheumatology, was performed using data from 361 consecutive patients with RA in clinical remission. The global assessment of disease activity by each patient (PGA) and evaluator/physician (EGA) was recorded on a 100-mm visual analogue scale. The PGA-EGA discordance was classified as positive (PGA>EGA) or negative (PGA

Published
2023

5. Relationship between the prevalence of subclinical tenosynovitis and treatment in patients with RA in clinical remission: STARTER study

Author

Parisi, S, Zanetti, A, Carrara, G, Scire, C, Iagnocco, A, Filippou, G, Batticciotto, A, Floris, A, Bortoluzzi, A, Gabba, A, Gattamelata, A, Adinolfi, A, Raffeiner, B, Venditti, C, Mastaglio, C, Scioscia, C, Rossi, D, Bellis, E, Luccioli, F, Cavatorta, F, Ceccarelli, F, Sakellariou, G, Cagnotto, G, Farina, I, Menza, L, Idolazzi, L, Canzoni, M, Massarotti, M, Focherini, M, Caprioli, M, Gutierrez, M, Draghessi, A, Piga, M, Muratore, M, De Lucia, O, Rossini, P, Macchioni, P, Ramonda, R, Rossi, S, Di Sabatino, V, Picerno, V, Parisi S., Zanetti A., Carrara G., Scire C. A., Iagnocco A., Filippou G., Batticciotto A., Floris A., Bortoluzzi A., Gabba A., Gattamelata A., Adinolfi A., Raffeiner B., Venditti C., Mastaglio C., Scioscia C., Rossi D., Bellis E., Luccioli F., Cavatorta F. P., Ceccarelli F., Sakellariou G., Cagnotto G., Farina I., Menza L., Idolazzi L., Canzoni M., Massarotti M., Focherini M. C., Caprioli M., Gutierrez M., Draghessi A., Piga M., Muratore M., De Lucia O., Rossini P., MacChioni P., Ramonda R., Rossi S., Di Sabatino V., Picerno V., Parisi, S, Zanetti, A, Carrara, G, Scire, C, Iagnocco, A, Filippou, G, Batticciotto, A, Floris, A, Bortoluzzi, A, Gabba, A, Gattamelata, A, Adinolfi, A, Raffeiner, B, Venditti, C, Mastaglio, C, Scioscia, C, Rossi, D, Bellis, E, Luccioli, F, Cavatorta, F, Ceccarelli, F, Sakellariou, G, Cagnotto, G, Farina, I, Menza, L, Idolazzi, L, Canzoni, M, Massarotti, M, Focherini, M, Caprioli, M, Gutierrez, M, Draghessi, A, Piga, M, Muratore, M, De Lucia, O, Rossini, P, Macchioni, P, Ramonda, R, Rossi, S, Di Sabatino, V, Picerno, V, Parisi S., Zanetti A., Carrara G., Scire C. A., Iagnocco A., Filippou G., Batticciotto A., Floris A., Bortoluzzi A., Gabba A., Gattamelata A., Adinolfi A., Raffeiner B., Venditti C., Mastaglio C., Scioscia C., Rossi D., Bellis E., Luccioli F., Cavatorta F. P., Ceccarelli F., Sakellariou G., Cagnotto G., Farina I., Menza L., Idolazzi L., Canzoni M., Massarotti M., Focherini M. C., Caprioli M., Gutierrez M., Draghessi A., Piga M., Muratore M., De Lucia O., Rossini P., MacChioni P., Ramonda R., Rossi S., Di Sabatino V., and Picerno V.

Abstract

Objective: This study is a sub-analysis from the patient cohort of the STARTER (Sonographic Tenosynovitis Assessment in RheumaToid arthritis patiEnts in Remission) study. The aim was to evaluate differences in ultrasound-detected joint and/or tendon involvement between patients receiving therapies based on a combination of conventional synthetic DMARDs (csDMARDs) and biologic DMARDs (bDMARDs) and those who were treated with either csDMARDs or bDMARDs in monotherapy. Material and methods: Four hundred and twenty-seven consecutive patients with a diagnosis of RA were recruited between October 2013 and June 2014. They were divided into three subgroups based on their therapy at baseline: patients with bDMARD in monotherapy, patients with csDMARD in monotherapy and patients in combination therapy (csDMARD + bDMARD). At baseline, 6 months and 12 months, a clinical examination (28 joint count) and an ultrasound evaluation were performed in each patient. A score of grey-scale (GS) and power Doppler (PD) synovitis and tenosynovitis was calculated based on the OMERACT scoring systems. Results: Two hundred and fifty-six patients completed the observation period: 48 patients from the bDMARD group (18.75%), 152 patients from the csDMARD group (59.38%) and 56 patients from csDMARD + bDMARD group (21.88%). The analysis showed that GS tenosynovitis and PD tenosynovitis are better controlled in combination therapy than they are ith csDMARD alone (P=0.025 and P=0.047, respectively); for PD synovitis, there was a better response in those who were treated with the combination therapy when compared with the patients receiving csDMARD (P=0.01) or bDMARD (P=0.02) alone. Conclusions: The analysis showed a lower prevalence of subclinical inflammatory manifestations detected with ultrasound imaging in those patients treated with the combination therapy than in those in monotherapy.

Published
2023

6. Musculoskeletal ultrasound may narrow the gap between patients and physicians in the assessment of rheumatoid arthritis disease activity

Author

Floris A., Rozza D., Zanetti A., Carrara G., Bellis E., Cauli A., Iagnocco A., Scire C. A., Piga M., Batticciotto A., Bortoluzzi A., Gabba A., Gattamelata A., Adinolfi A., Raffeiner B., Vinghitti C., Mastaglio C., Scioscia C., Russi D., Luccioli F., Cavatorta F., Ceccarelli F., Sakellariou G., Filippou G., Cagnotto G., Farina I., Menza L., Idolazzi L., Canzoni M., Massarotti M., Focherini M., Caprioli M., Gutierrez M., Draghessi A., Muratore M., De Lucia O., Rossini P., MacChioni P., Ramonda R., Rossi S., Parisi S., Sabatino V. D., Picerno V., Floris, A, Rozza, D, Zanetti, A, Carrara, G, Bellis, E, Cauli, A, Iagnocco, A, Scire, C, Piga, M, Batticciotto, A, Bortoluzzi, A, Gabba, A, Gattamelata, A, Adinolfi, A, Raffeiner, B, Vinghitti, C, Mastaglio, C, Scioscia, C, Russi, D, Luccioli, F, Cavatorta, F, Ceccarelli, F, Sakellariou, G, Filippou, G, Cagnotto, G, Farina, I, Menza, L, Idolazzi, L, Canzoni, M, Massarotti, M, Focherini, M, Caprioli, M, Gutierrez, M, Draghessi, A, Muratore, M, De Lucia, O, Rossini, P, Macchioni, P, Ramonda, R, Rossi, S, Parisi, S, Sabatino, V, and Picerno, V

Subjects
rheumatoid arthritis, remission, Rheumatology, patient–physician discordance, patient global assessment, Pharmacology (medical), patient-physician discordance, ultrasonography, RA
Abstract

Objectives To investigate the association between patient–physician discordance in the assessment of disease activity and residual US synovitis/tenosynovitis in a cohort of patients with RA in clinical remission. Methods A post hoc analysis of the STARTER study, promoted by the Musculoskeletal-US (MSUS) Study Group of the Italian Society for Rheumatology, was performed using data from 361 consecutive patients with RA in clinical remission. The global assessment of disease activity by each patient (PGA) and evaluator/physician (EGA) was recorded on a 100-mm visual analogue scale. The PGA-EGA discordance was classified as positive (PGA>EGA) or negative (PGA Results The mean (s.d.) PGA and EGA scores were 6.1 (7.1) and 8.8 (12) mm, respectively, with a median (IQR) absolute difference of 4 (0–10) mm. Positive and negative discordances were recorded in 39 (10.8%) and 65(18.0%) patients, respectively. The GS-S (adjOR 1.099) and PD-S (adjOR 1.167) scores were associated with positive discordance (P Conclusions Patient–physician discordance is associated with the lack of US remission in patients with RA and may represent a further indication for MSUS.

Published
2022
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7. Reliability assessment of the definition of ultrasound enthesitis in SpA: results of a large, multicentre, international, web-based study

Author

Di Matteo, A, Cipolletta, E, Castaniti, G, Smerilli, G, Airoldi, C, Aydin, S, Becciolini, A, Bonfiglioli, K, Bruns, A, Carrara, G, Cazenave, T, Ciapetti, A, Cosatti, M, de Agustin, J, Di Carlo, M, Di Donato, E, Di Geso, L, Duran, E, Elliott, A, Estrach, C, Farisogullari, B, Fiorenza, A, Fodor, D, Gabba, A, Hernandez-Diaz, C, Huang, F, Hurnakova, J, Li, L, Jesus, D, Karadag, O, Martire, M, Massarotti, M, Michelena, X, Musca, A, Nair, J, Okano, T, Papalopoulos, I, Rosemffet, M, Rovisco, J, Rozza, D, Salaffi, F, Satulu, I, Scioscia, C, Scire, C, Sun, F, Tamas, M, Tanimura, S, Ventura-Rios, L, Voulgari, P, Vreju, F, Vukatana, G, Wong, E, Yang, J, Hereter, J, Zanetti, A, Grassi, W, Filippucci, E, Di Matteo A., Cipolletta E., Castaniti G. M. D., Smerilli G., Airoldi C., Aydin S. Z., Becciolini A., Bonfiglioli K., Bruns A., Carrara G., Cazenave T., Ciapetti A., Cosatti M. A., de Agustin J. J., Di Carlo M., Di Donato E., Di Geso L., Duran E., Elliott A., Estrach C., Farisogullari B., Fiorenza A., Fodor D., Gabba A., Hernandez-Diaz C., Huang F., Hurnakova J., Li L., Jesus D., Karadag O., Martire M. V., Massarotti M., Michelena X., Musca A. A., Nair J., Okano T., Papalopoulos I., Rosemffet M., Rovisco J., Rozza D., Salaffi F., Satulu I., Scioscia C., Scire C. A., Sun F., Tamas M. -M., Tanimura S., Ventura-Rios L., Voulgari P. V., Vreju F. A., Vukatana G., Wong E., Yang J., Hereter J. Z., Zanetti A., Grassi W., Filippucci E., Di Matteo, A, Cipolletta, E, Castaniti, G, Smerilli, G, Airoldi, C, Aydin, S, Becciolini, A, Bonfiglioli, K, Bruns, A, Carrara, G, Cazenave, T, Ciapetti, A, Cosatti, M, de Agustin, J, Di Carlo, M, Di Donato, E, Di Geso, L, Duran, E, Elliott, A, Estrach, C, Farisogullari, B, Fiorenza, A, Fodor, D, Gabba, A, Hernandez-Diaz, C, Huang, F, Hurnakova, J, Li, L, Jesus, D, Karadag, O, Martire, M, Massarotti, M, Michelena, X, Musca, A, Nair, J, Okano, T, Papalopoulos, I, Rosemffet, M, Rovisco, J, Rozza, D, Salaffi, F, Satulu, I, Scioscia, C, Scire, C, Sun, F, Tamas, M, Tanimura, S, Ventura-Rios, L, Voulgari, P, Vreju, F, Vukatana, G, Wong, E, Yang, J, Hereter, J, Zanetti, A, Grassi, W, Filippucci, E, Di Matteo A., Cipolletta E., Castaniti G. M. D., Smerilli G., Airoldi C., Aydin S. Z., Becciolini A., Bonfiglioli K., Bruns A., Carrara G., Cazenave T., Ciapetti A., Cosatti M. A., de Agustin J. J., Di Carlo M., Di Donato E., Di Geso L., Duran E., Elliott A., Estrach C., Farisogullari B., Fiorenza A., Fodor D., Gabba A., Hernandez-Diaz C., Huang F., Hurnakova J., Li L., Jesus D., Karadag O., Martire M. V., Massarotti M., Michelena X., Musca A. A., Nair J., Okano T., Papalopoulos I., Rosemffet M., Rovisco J., Rozza D., Salaffi F., Satulu I., Scioscia C., Scire C. A., Sun F., Tamas M. -M., Tanimura S., Ventura-Rios L., Voulgari P. V., Vreju F. A., Vukatana G., Wong E., Yang J., Hereter J. Z., Zanetti A., Grassi W., and Filippucci E.

Abstract

Objectives. To investigate the reliability of the OMERACT US Task Force definition of US enthesitis in SpA. Methods. In this web exercise, based on the evaluation of 101 images and 39 clips of the main entheses of the lower limbs, the elementary components included in the OMERACT definition of US enthesitis in SpA (hypoechoic areas, entheseal thickening, power Doppler signal at the enthesis, enthesophytes/calcifications, bone erosions) were assessed by 47 rheumatologists from 37 rheumatology centres in 15 countries. Inter- and intra-observer reliability of the US components of enthesitis was calculated using Light’s kappa, Cohen’s kappa, Prevalence And Bias Adjusted Kappa (PABAK) and their 95% CIs. Results. Bone erosions and power Doppler signal at the enthesis showed the highest overall inter-reliability [Light’s kappa: 0.77 (0.76–0.78), 0.72 (0.71–0.73), respectively; PABAK: 0.86 (0.86–0.87), 0.73 (0.73–0.74), respectively], followed by enthesophytes/calcifications [Light’s kappa: 0.65 (0.64–0.65), PABAK: 0.67 (0.67–0.68)]. This was moderate for entheseal thickening [Light’s kappa: 0.41 (0.41–0.42), PABAK: 0.41 (0.40–0.42)], and fair for hypoechoic areas [Light’s kappa: 0.37 (0.36–0.38); PABAK: 0.37 (0.37–0.38)]. A similar trend was observed in the intra-reliability exercise, although this was characterized by an overall higher degree of reliability for all US elementary components compared with the inter-observer evaluation. Conclusions. The results of this multicentre, international, web-based study show a good reliability of the OMERACT US definition of bone erosions, power Doppler signal at the enthesis and enthesophytes/calcifications. The low reliability of entheseal thickening and hypoechoic areas raises questions about the opportunity to revise the definition of these two major components for the US diagnosis of enthesitis.

Published
2022

9. POS0703 BIOLOGIC-DMARDS AND TARGETED SYNTHETIC-DMARDS EFFECT ON RAPID WITHDRAWAL OF STEROID IN 6 MONTHS OBSERVATIONAL PERIOD IN RHEUMATOID ARTHRITIS PATIENT’S COHORT: REAL LIFE DATA EXTRACTED FROM BIOPURE REGISTRY.

Author

Rotondo, C., primary, Corrado, A., additional, Fornaro, M., additional, Bucci, R. N. G., additional, Carlino, G., additional, D’onofrio, F., additional, Falappone, P. C. F., additional, Leucci, P. F., additional, Marsico, A., additional, Maruotti, N., additional, Mazzotta, D., additional, Quarta, L., additional, Santo, L., additional, Scioscia, C., additional, Semeraro, A., additional, Zuccaro, C., additional, Quarta, E., additional, Iannone, F., additional, and Cantatore, F. P., additional

Published
2022
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12. Ultrasonography in psoriatic arthritis: Which sites should we scan?

Author

Zabotti, A, Piga, M, Canzoni, M, Sakellariou, G, Iagnocco, A, Scire, C, Adinolfi, A, Azzolin, I, Bandinelli, F, Batticciotto, A, Boffini, N, Bortoluzzi, A, Carrara, G, Cavatorta, F, Cagnotto, G, Caprioli, M, Colaci, M, De Lucia, O, Delle Sedie, A, Denaro, V, Di Matteo, A, Di Sabatino, V, Epis, O, Hoxha, A, Farina, I, Germano, G, Filippou, G, Filippucci, E, Focherini, M, Gabba, A, Idolazzi, L, La Paglia, G, Luccioli, F, Macchioni, P, Magnani, M, Massarotti, M, Mastaglio, C, Navarini, L, Parisi, S, Diamanti, A, Picerno, V, Piras, M, Porta, F, Possemato, N, Prevete, I, Raffeiner, B, Ramonda, R, Ravagnani, V, Rossi, D, Rossi, S, Scolieri, P, Santoboni, G, Scioscia, C, Terenzi, R, Tinazzi, I, Toscano, C, Venditti, C, Volpe, A, Vukatana, G, Zanframundo, G, Zabotti A., Piga M., Canzoni M., Sakellariou G., Iagnocco A., Scire C. A., Adinolfi A., Azzolin I., Bandinelli F., Batticciotto A., Boffini N., Bortoluzzi A., Carrara G., Cavatorta F. P., Cagnotto G., Caprioli M., Colaci M., De Lucia O., Delle Sedie A., Denaro V., Di Matteo A., Di Sabatino V., Epis O. M., Hoxha A., Farina I., Germano G., Filippou G., Filippucci E., Focherini M. C., Gabba A., Idolazzi L., La Paglia G. M. C., Luccioli F., Macchioni P., Magnani M., Massarotti M., Mastaglio C., Navarini L., Parisi S., Diamanti A. P., Picerno V., Piras M., Porta F., Possemato N., Prevete I., Raffeiner B., Ramonda R., Ravagnani V., Rossi D., Rossi S., Scolieri P., Santoboni G., Scioscia C., Terenzi R., Tinazzi I., Toscano C., Venditti C., Volpe A., Vukatana G., Zanframundo G., Zabotti, A, Piga, M, Canzoni, M, Sakellariou, G, Iagnocco, A, Scire, C, Adinolfi, A, Azzolin, I, Bandinelli, F, Batticciotto, A, Boffini, N, Bortoluzzi, A, Carrara, G, Cavatorta, F, Cagnotto, G, Caprioli, M, Colaci, M, De Lucia, O, Delle Sedie, A, Denaro, V, Di Matteo, A, Di Sabatino, V, Epis, O, Hoxha, A, Farina, I, Germano, G, Filippou, G, Filippucci, E, Focherini, M, Gabba, A, Idolazzi, L, La Paglia, G, Luccioli, F, Macchioni, P, Magnani, M, Massarotti, M, Mastaglio, C, Navarini, L, Parisi, S, Diamanti, A, Picerno, V, Piras, M, Porta, F, Possemato, N, Prevete, I, Raffeiner, B, Ramonda, R, Ravagnani, V, Rossi, D, Rossi, S, Scolieri, P, Santoboni, G, Scioscia, C, Terenzi, R, Tinazzi, I, Toscano, C, Venditti, C, Volpe, A, Vukatana, G, Zanframundo, G, Zabotti A., Piga M., Canzoni M., Sakellariou G., Iagnocco A., Scire C. A., Adinolfi A., Azzolin I., Bandinelli F., Batticciotto A., Boffini N., Bortoluzzi A., Carrara G., Cavatorta F. P., Cagnotto G., Caprioli M., Colaci M., De Lucia O., Delle Sedie A., Denaro V., Di Matteo A., Di Sabatino V., Epis O. M., Hoxha A., Farina I., Germano G., Filippou G., Filippucci E., Focherini M. C., Gabba A., Idolazzi L., La Paglia G. M. C., Luccioli F., Macchioni P., Magnani M., Massarotti M., Mastaglio C., Navarini L., Parisi S., Diamanti A. P., Picerno V., Piras M., Porta F., Possemato N., Prevete I., Raffeiner B., Ramonda R., Ravagnani V., Rossi D., Rossi S., Scolieri P., Santoboni G., Scioscia C., Terenzi R., Tinazzi I., Toscano C., Venditti C., Volpe A., Vukatana G., and Zanframundo G.

Published
2018

13. The predictive role of ultrasound-detected tenosynovitis and joint synovitis for flare in patients with rheumatoid arthritis in stable remission. Results of an Italian multicentre study of the Italian Society for Rheumatology Group for Ultrasound: The STARTER study

Author

Filippou, G, Sakellariou, G, Scire, C, Carrara, G, Rumi, F, Bellis, E, Adinolfi, A, Batticciotto, A, Bortoluzzi, A, Cagnotto, G, Caprioli, M, Canzoni, M, Cavatorta, F, De Lucia, O, Di Sabatino, V, Draghessi, A, Farina, I, Focherini, M, Gabba, A, Gutierrez, M, Idolazzi, L, Luccioli, F, Macchioni, P, Massarotti, M, Mastaglio, C, Menza, L, Muratore, M, Parisi, S, Picerno, V, Piga, M, Ramonda, R, Raffeiner, B, Rossi, D, Rossi, S, Rossini, P, Scioscia, C, Venditti, C, Volpe, A, Iagnocco, A, Filippou G., Sakellariou G., Scire C. A., Carrara G., Rumi F., Bellis E., Adinolfi A., Batticciotto A., Bortoluzzi A., Cagnotto G., Caprioli M., Canzoni M., Cavatorta F. P., De Lucia O., Di Sabatino V., Draghessi A., Farina I., Focherini M. C., Gabba A., Gutierrez M., Idolazzi L., Luccioli F., MacChioni P., Massarotti M. S., Mastaglio C., Menza L., Muratore M., Parisi S., Picerno V., Piga M., Ramonda R., Raffeiner B., Rossi D., Rossi S., Rossini P., Scioscia C., Venditti C., Volpe A., Iagnocco A., Filippou, G, Sakellariou, G, Scire, C, Carrara, G, Rumi, F, Bellis, E, Adinolfi, A, Batticciotto, A, Bortoluzzi, A, Cagnotto, G, Caprioli, M, Canzoni, M, Cavatorta, F, De Lucia, O, Di Sabatino, V, Draghessi, A, Farina, I, Focherini, M, Gabba, A, Gutierrez, M, Idolazzi, L, Luccioli, F, Macchioni, P, Massarotti, M, Mastaglio, C, Menza, L, Muratore, M, Parisi, S, Picerno, V, Piga, M, Ramonda, R, Raffeiner, B, Rossi, D, Rossi, S, Rossini, P, Scioscia, C, Venditti, C, Volpe, A, Iagnocco, A, Filippou G., Sakellariou G., Scire C. A., Carrara G., Rumi F., Bellis E., Adinolfi A., Batticciotto A., Bortoluzzi A., Cagnotto G., Caprioli M., Canzoni M., Cavatorta F. P., De Lucia O., Di Sabatino V., Draghessi A., Farina I., Focherini M. C., Gabba A., Gutierrez M., Idolazzi L., Luccioli F., MacChioni P., Massarotti M. S., Mastaglio C., Menza L., Muratore M., Parisi S., Picerno V., Piga M., Ramonda R., Raffeiner B., Rossi D., Rossi S., Rossini P., Scioscia C., Venditti C., Volpe A., and Iagnocco A.

Abstract

Objective To define the role of ultrasound (US) for the assessment of patients with rheumatoid arthritis (RA) in clinical remission, including joint and tendon evaluation. Methods A multicentre longitudinal study has been promoted by the US Study Group of the Italian Society for Rheumatology. 25 Italian centres participated, enrolling consecutive patients with RA in clinical remission. All patients underwent complete clinical assessment (demographic data, disease characteristics, laboratory exams, clinical assessment of 28 joints and patient/physician-reported outcomes) and Power Doppler (PD) US evaluation of wrist, metacarpalphalangeal joints, proximal interphalangeal joints and synovial tendons of the hands and wrists at enrolment, 6 and 12 months. The association between clinical and US variables with flare, disability and radiographic progression was evaluated by univariable and adjusted logistic regression models. Results 361 patients were enrolled, the mean age was 56.20 (±13.31) years and 261 were women, with a mean disease duration of 9.75 (±8.07) years. In the 12 months follow-up, 98/326 (30.1%) patients presented a disease flare. The concurrent presence of PD positive tenosynovitis and joint synovitis predicted disease flare, with an OR (95% CI) of 2.75 (1.45 to 5.20) in crude analyses and 2.09 (1.06 to 4.13) in adjusted analyses. US variables did not predict the worsening of function or radiographic progression. US was able to predict flare at 12 months but not at 6 months. Conclusions PD positivity in tendons and joints is an independent risk factor of flare in patients with RA in clinical remission. Musculoskeletal ultrasound evaluation is a valuable tool to monitor and help decision making in patients with RA in clinical remission.

Published
2018

18. Ultrasonography in psoriatic arthritis: which sites should we scan?

Author

Zabotti A., Piga M., Canzoni M., Sakellariou G., Iagnocco A., Scire C. A., Adinolfi A., Azzolin I., Bandinelli F., Batticciotto A., Boffini N., Bortoluzzi A., Carrara G., Cavatorta F. P., Cagnotto G., Caprioli M., Colaci M., De Lucia O., Delle Sedie A., Denaro V., Di Matteo A., Di Sabatino V., Epis O. M., Hoxha A., Farina I., Germano G., Filippou G., Filippucci E., Focherini M. C., Gabba A., Idolazzi L., La Paglia G. M. C., Luccioli F., Macchioni P., Magnani M., Massarotti M., Mastaglio C., Navarini L., Parisi S., Diamanti A. P., Picerno V., Piras M., Porta F., Possemato N., Prevete I., Raffeiner B., Ramonda R., Ravagnani V., Rossi D., Rossi S., Scolieri P., Santoboni G., Scioscia C., Terenzi R., Tinazzi I., Toscano C., Venditti C., Volpe A., Vukatana G., Zanframundo G., Zabotti, A, Piga, M, Canzoni, M, Sakellariou, G, Iagnocco, A, Scire, C, Adinolfi, A, Azzolin, I, Bandinelli, F, Batticciotto, A, Boffini, N, Bortoluzzi, A, Carrara, G, Cavatorta, F, Cagnotto, G, Caprioli, M, Colaci, M, De Lucia, O, Delle Sedie, A, Denaro, V, Di Matteo, A, Di Sabatino, V, Epis, O, Hoxha, A, Farina, I, Germano, G, Filippou, G, Filippucci, E, Focherini, M, Gabba, A, Idolazzi, L, La Paglia, G, Luccioli, F, Macchioni, P, Magnani, M, Massarotti, M, Mastaglio, C, Navarini, L, Parisi, S, Diamanti, A, Picerno, V, Piras, M, Porta, F, Possemato, N, Prevete, I, Raffeiner, B, Ramonda, R, Ravagnani, V, Rossi, D, Rossi, S, Scolieri, P, Santoboni, G, Scioscia, C, Terenzi, R, Tinazzi, I, Toscano, C, Venditti, C, Volpe, A, Vukatana, G, and Zanframundo, G

Subjects
Genetics and Molecular Biology (all), medicine.medical_specialty, Immunology, Arthritis, Physical examination, outcomes research, psoriatic arthritis, ultrasonography, rheumatology, immunology and allergy, immunology, biochemistry, genetics and molecular biology (all), Disease, Biochemistry, Sensitivity and Specificity, General Biochemistry, Genetics and Molecular Biology, Rheumatology, Immunology and Allergy, Biochemistry, Genetics and Molecular Biology (all), NO, Tendons, 03 medical and health sciences, Psoriatic arthritis, 0302 clinical medicine, Internal medicine, medicine, Humans, 030212 general & internal medicine, Prospective cohort study, 030203 arthritis & rheumatology, medicine.diagnostic_test, business.industry, outcomes research, psoriatic arthritis, ultrasonography, Arthritis, Psoriatic, Bursa, Synovial, medicine.disease, Joints, Observational study, Differential diagnosis, business
Abstract

In psoriatic arthritis (PsA), ultrasonography (US) plays a growing role in the differential diagnosis and in monitoring treatment response.1 PsA is a heterogeneous disease with different domains and peculiar sites involved.2 Therefore, a dedicated US composite score is needed to monitor disease activity and to identify structural damage progression. A recently published Systematic Literature Review (SLR) identified only two US scores specifically developed for PsA (ie, 5TPD and PsA-Son) and, although these had a good sensitivity to detect inflammation and a good feasibility, they have not been validated in other series.1 3 4 Recently, the Study Group for US of the Italian Society of Rheumatology promoted the Ultrasound in PSoriatic Arthritis TREAtMent (UPSTREAM) study (registered at ClinicalTrial.gov, NCT03330769). UPSTREAM is a multicentre observational prospective cohort study and it represents the first …

Published
2018
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19. Ultrasound-detected tenosynovitis independently associates with patient-reported flare in patients with rheumatoid arthritis in clinical remission: Results from the observational study STARTER of the Italian Society for Rheumatology

Author

Bellis, E, Scire, C, Carrara, G, Adinolfi, A, Batticciotto, A, Bortoluzzi, A, Cagnotto, G, Caprioli, M, Canzoni, M, Cavatorta, F, De Lucia, O, Di Sabatino, V, Draghessi, A, Filippou, G, Farina, I, Focherini, M, Gabba, A, Gutierrez, M, Idolazzi, L, Luccioli, F, Macchioni, P, Massarotti, M, Mastaglio, C, Menza, L, Muratore, M, Parisi, S, Picerno, V, Piga, M, Ramonda, R, Raffeiner, B, Rossi, D, Rossi, S, Rossini, P, Sakellariou, G, Scioscia, C, Venditti, C, Volpe, A, Matucci-Cerinic, M, Iagnocco, A, Bellis E., Scire C. A., Carrara G., Adinolfi A., Batticciotto A., Bortoluzzi A., Cagnotto G., Caprioli M., Canzoni M., Cavatorta F. P., De Lucia O., Di Sabatino V., Draghessi A., Filippou G., Farina I., Focherini M. C., Gabba A., Gutierrez M., Idolazzi L., Luccioli F., Macchioni P., Massarotti M. S., Mastaglio C., Menza L., Muratore M., Parisi S., Picerno V., Piga M., Ramonda R., Raffeiner B., Rossi D., Rossi S., Rossini P., Sakellariou G., Scioscia C., Venditti C., Volpe A., Matucci-Cerinic M., Iagnocco A., Bellis, E, Scire, C, Carrara, G, Adinolfi, A, Batticciotto, A, Bortoluzzi, A, Cagnotto, G, Caprioli, M, Canzoni, M, Cavatorta, F, De Lucia, O, Di Sabatino, V, Draghessi, A, Filippou, G, Farina, I, Focherini, M, Gabba, A, Gutierrez, M, Idolazzi, L, Luccioli, F, Macchioni, P, Massarotti, M, Mastaglio, C, Menza, L, Muratore, M, Parisi, S, Picerno, V, Piga, M, Ramonda, R, Raffeiner, B, Rossi, D, Rossi, S, Rossini, P, Sakellariou, G, Scioscia, C, Venditti, C, Volpe, A, Matucci-Cerinic, M, Iagnocco, A, Bellis E., Scire C. A., Carrara G., Adinolfi A., Batticciotto A., Bortoluzzi A., Cagnotto G., Caprioli M., Canzoni M., Cavatorta F. P., De Lucia O., Di Sabatino V., Draghessi A., Filippou G., Farina I., Focherini M. C., Gabba A., Gutierrez M., Idolazzi L., Luccioli F., Macchioni P., Massarotti M. S., Mastaglio C., Menza L., Muratore M., Parisi S., Picerno V., Piga M., Ramonda R., Raffeiner B., Rossi D., Rossi S., Rossini P., Sakellariou G., Scioscia C., Venditti C., Volpe A., Matucci-Cerinic M., and Iagnocco A.

Abstract

Objectives. This study aimed to estimate the prevalence of US-detected tenosynovitis in RA patients in clinical remission and to explore its clinical correlates.Methods. A total of 427 RA patients in clinical remission were consecutively enrolled from 25 Italian rheumatology centres. Tenosynovitis and synovitis were scored by US grey scale (GS) and power Doppler (PD) semi-quantitative scoring systems at wrist and hand joints. Complete clinical assessment was performed by rheumatologists blinded to the US results. A flare questionnaire was used to assess unstable remission (primary outcome), HAQ for functional disability and radiographic erosions for damage (secondary outcomes). Cross-sectional relationships between the presence of each US finding and outcome variables are presented as odds ratios (ORs) and 95% CIs, both crude and adjusted for pre-specified confounders.Results. The prevalence of tenosynovitis in clinical remission was 52.5% (95% CI 0.48, 0.57) for GS and 22.7% (95% CI 0.19, 0.27) for PD, while the prevalence of synovitis was 71.6% (95% CI 0.67, 0.76) for GS and 42% (95% CI 0.37, 0.47) for PD. Among clinical correlates, PD tenosynovitis associated with lower remission duration and morning stiffness while PD synovitis did not. Only PD tenosynovitis showed a significant association with the flare questionnaire [OR 1.95 (95% CI 1.17, 3.26)]. No cross-sectional associations were found with the HAQ. The presence of radiographic erosions associated with GS and PD synovitis but not with tenosynovitis.Conclusions. US-detected tenosynovitis is a frequent finding in RA patients in clinical remission and associates with unstable remission.

Published
2016

20. THU0168 Relationships between body fat composition assessed with bioelectrical impedance analysis, serum adipokines and disease activity in patients with rheumatoid arthritis

Author

Anelli, M.G., primary, Venerito, V., additional, Lopalco, G., additional, Cacciapaglia, F., additional, Scioscia, C., additional, Giannotta, M., additional, Righetti, G., additional, Montini, F., additional, Natuzzi, D., additional, Bizzoca, R., additional, Lacarpia, N., additional, Fanizzi, R., additional, Lapadula, G., additional, and Iannone, F., additional

Published
2018
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22. AB0836 Drug retention rate of the first tnf inhibitor in radiographic and non radiographic axial spondyloarthritis: data from a multicenter study

Author

Lopalco, G., primary, Venerito, V., additional, Cantarini, L., additional, Emmi, G., additional, Salaffi, F., additional, Tafuri, S., additional, Bianchi, F.P., additional, Di Carlo, M., additional, Gentileschi, S., additional, Di Scala, G., additional, Nivuori, M., additional, Perniola, S., additional, Fornaro, M., additional, Anelli, M.G., additional, Cacciapaglia, F., additional, Scioscia, C., additional, Fabiani, C., additional, Galeazzi, M., additional, Lapadula, G., additional, and Iannone, F., additional

Published
2018
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25. High rate of disease remission in moderate rheumatoid arthritis on etanercept therapy: data from GISEA, the Italian biologics register

Author

Iannone, F, Gremese, E, Gallo, G, Sarzi Puttini, P, Botsios, C, Trotta, F, Gasperini, S, Galeazzi, Mauro, Adami, S, Cantini, F, Sebastiani, M, Gorla, R, Marchesoni, A, Giardina, A, Foti, R, Mele, A, Bruschi, E, Bagnato, G, Erre, G. L., Lapadula, G, Scioscia, C, Fedele, A. L., Ferraccioli, G, Atzeni, F, Bongiovanni, S, Punzi, L, Bernardi, L, Bagnari, V, Govoni, M, Grassi, W, Salaffi, F, Manganelli, S, Frati, Elena, Carletto, A, Caimmi, C, Palloni, A, Niccoli, L, Ferri, C, Favalli, E. G., Triolo, G, and Di Gangi, M.

Subjects
rheumatoid arthritis, Male, Settore MED/16 - REUMATOLOGIA, Disease, Severity of Illness Index, Receptors, Tumor Necrosis Factor, Etanercept, Arthritis, Rheumatoid, Disease remission, Surveys and Questionnaires, Prospective Studies, Registries, Young adult, skin and connective tissue diseases, Prospective cohort study, GISEA, TNF-α inhibitors, Aged, 80 and over, Remission Induction, General Medicine, Middle Aged, rheumatoid artritis, Treatment Outcome, Italy, Antirheumatic Agents, Rheumatoid arthritis, Drug Therapy, Combination, Female, medicine.drug, Adult, musculoskeletal diseases, medicine.medical_specialty, Adolescent, Young Adult, remission, Rheumatology, Internal medicine, Severity of illness, medicine, Humans, DAS28, Glucocorticoids, Aged, Biological Products, Tumor Necrosis Factor-alpha, business.industry, HAQ, medicine.disease, Surgery, Methotrexate, Immunoglobulin G, business, etanercept
Abstract

The aim of this study was to evaluate the clinical outcomes of etanercept in rheumatoid arthritis (RA) patients with moderate or severe disease activity. We analyzed data from the Italian biologics register Gruppo Italiano Studio Early Arthritides (GISEA) to investigate the rate of disease remission and functional improvement, based on the 28-Joint Disease Activity Score (DAS28) and the (Health Assessment Questionnaire (HAQ) score in RA patients with moderate or severe disease activity beginning etanercept therapy. Disease was defined as severe (H-RA) with DAS28 ≥5.1 and moderate (M-RA) with DAS28 ≥3.2 to 5.1 at baseline. Patients were considered in remission if DAS28 was ≤2.6, and HAQ ≤0.5 defined normal function. We enrolled 953 RA patients, 320 with M-RA and 633 H-RA. Age and disease duration were similar in the two cohorts, but H-RA patients had significantly more comorbidities (p < 0.01) and took significantly more disease-modifying antirheumatic drugs (p < 0.001) than M-RA patients. After 1 year, the percentage of patients achieving disease remission and normal function (DAS28 ≤2.6 plus HAQ ≤0.5) was higher in M-RA (21.4 %) than in H-RA patients (14.8 %, p = 0.007), regardless of the disease duration. Additionally, female gender (p = 0.006) and H-RA class (p = 0.002) negatively predicted disease remission at 1 year. However, the drug survival rate did not differ between the two subsets. This study confirms that etanercept was effective in the treatment of active RA, but best response, in terms of disease remission and normal function ability, was greater and easier to attain in M-RA patients. These findings may aid clinicians to choose the best strategy to treat RA.

Published
2013
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26. AB0618 A unique ultrasound pattern of adipose tissue in systemic sclerosis patients: a comparison with rheumatoid arthritis patients and healthy controls. two sides of adipose tissue involvement in systemic chronic inflammatory diseases

Author

Rotondo, C, primary, Fanizzi, R, additional, Chialà, A, additional, Anelli, MG, additional, Righetti, G, additional, Nivuori, M, additional, Praino, E, additional, Dinoia, L, additional, Lopriore, S, additional, Laselva, G, additional, Scioscia, C, additional, Cacciapaglia, F, additional, Lapadula, G, additional, and Iannone, F, additional

Published
2017
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27. FRI0110 Methotrexate monotherapy in real life: a drug survival analysis. comparison between very early arthritis and early arthritis cohorts

Author

Anelli, MG, primary, Rotondo, C, additional, Righetti, G, additional, Rinaldi, A, additional, Perniola, S, additional, Nivuori, M, additional, Lopriore, S, additional, Lopalco, G, additional, Laselva, G, additional, Scioscia, C, additional, Cacciapaglia, F, additional, Lapadula, G, additional, and Iannone, F, additional

Published
2017
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29. The Italian MSUS Study Group recommendations for the format and content of the report and documentation in musculoskeletal ultrasonography in rheumatology

Author

Iagnocco A, Porta F, CUOMO, Giovanna, Delle Sedie A, Filippucci E, Grassi W, Sakellariou G, Epis O, Adinolfi A, Ceccarelli F, De Lucia O, Di Geso L, Di Sabatino V, Gabba A, Gattamelata A, Gutierrez M, Massaro L, Massarotti M, Perricone C, Picerno V, Ravagnani V, Riente L, Scioscia C, Naredo E, Filippou G, Musculoskeletal Ultrasound Study Group of the Italian Society of Rheumatology, Iagnocco, A, Porta, F, Cuomo, Giovanna, Delle Sedie, A, Filippucci, E, Grassi, W, Sakellariou, G, Epis, O, Adinolfi, A, Ceccarelli, F, De Lucia, O, Di Geso, L, Di Sabatino, V, Gabba, A, Gattamelata, A, Gutierrez, M, Massaro, L, Massarotti, M, Perricone, C, Picerno, V, Ravagnani, V, Riente, L, Scioscia, C, Naredo, E, Filippou, G, and Musculoskeletal Ultrasound Study Group of the Italian Society of, Rheumatology

Subjects
Pathology, medicine.medical_specialty, Delphi Technique, Delphi method, Recommendations, Documentation, Rheumatology, Musculoskeletal ultrasonography, Internal medicine, Report, Rheumatic Diseases, Ultrasound, Medicine, Humans, Medical physics, Pharmacology (medical), recommendations, report, ultrasound, Grading (education), Musculoskeletal System, computer.programming_language, Ultrasonography, Response rate (survey), Modalities, business.industry, Italy, business, computer, Delphi
Abstract

Objective:The objective of this study was to draw up a set of recommendations for the format and content of the musculoskeletal ultrasonography (MSUS) report in rheumatology. METHODS: A panel of rheumatologists, members of the MSUS Study Group of the Italian Society of Rheumatology, met in order to identify the main discrepancies in the MSUS report. A set of 15 recommendations was then defined, aimed at resolving the main discrepancies. They consisted of information about the motivations for the MSUS examination, the equipment, the US modalities and scanning technique, a list of the examined structures and findings, the scoring/grading systems, the number of images and main findings to include and conclusions. Subsequently a Delphi-based procedure was started in order to obtain agreement on a core set of recommendations. Consensus for each recommendation was considered achieved when the percentage of agreement was >75%. RESULTS: Three complete rounds were performed. The response rate was 85.2% for the first round, 78.3% for the second and 88.9% for the third. Finally, consensus was obtained for 14 of 15 statements. These 14 statements represent the recommendations of the group for the format and content of the report and documentation in MSUS in rheumatology. CONCLUSION: To the best of our knowledge, our group has produced the first recommendations for the format and content of the report and documentation in MSUS in rheumatology. The report is an integral part of the MSUS examination and its use in a homogeneous form can help in the correct interpretation of the findings.

Published
2013

30. Evidence-based algorithm for diagnosis and assessment in psoriatic arthritis: Results by Italian DELphi in psoriatic arthritis (IDEA)

Author

Lapadula, Giovanni, Marchesoni, A., Salaffi, F., Ramonda, R., Salvarani, C., Punzi, L., Costa, Luigi, Caso, F., Simone, D., Baiocchi, G., Scioscia, C., Di Carlo, M., Scarpa, R., Ferraccioli, Gianfranco, Ferraccioli, Gianfranco (ORCID:0000-0001-6246-2428), Lapadula, Giovanni, Marchesoni, A., Salaffi, F., Ramonda, R., Salvarani, C., Punzi, L., Costa, Luigi, Caso, F., Simone, D., Baiocchi, G., Scioscia, C., Di Carlo, M., Scarpa, R., Ferraccioli, Gianfranco, and Ferraccioli, Gianfranco (ORCID:0000-0001-6246-2428)

Abstract

Psoriatic arthritis (PsA) is a chronic inflammatory disease involving skin, peripheral joints, entheses, and axial skeleton. The disease is frequently associated with extrarticular manifestations (EAMs) and comorbidities. In order to create a protocol for PsA diagnosis and global assessment of patients with an algorithm based on anamnestic, clinical, laboratory and imaging procedures, we established a DElphi study on a national scale, named Italian DElphi in psoriatic Arthritis (IDEA). After a literature search, a Delphi poll, involving 52 rheumatologists, was performed. On the basis of the literature search, 202 potential items were identified. The steering committee planned at least two Delphi rounds. In the first Delphi round, the experts judged each of the 202 items using a score ranging from 1 to 9 based on its increasing clinical relevance. The questions posed to experts were How relevant is this procedure/observation/sign/symptom for assessment of a psoriatic arthritis patient? Proposals of additional items, not included in the questionnaire, were also encouraged. The results of the poll were discussed by the Steering Committee, which evaluated the necessity for removing selected procedures or adding additional ones, according to criteria of clinical appropriateness and sustainability. A total of 43 recommended diagnosis and assessment procedures, recognized as items, were derived by combination of the Delphi survey and two National Expert Meetings, and grouped in different areas. Favourable opinion was reached in 100% of cases for several aspects covering the following areas: medical (familial and personal) history, physical evaluation, imaging tool, second level laboratory tests, disease activity measurement and extrarticular manifestations. After performing PsA diagnosis, identification of specific disease activity scores and clinimetric approaches were suggested for assessing the different clinical subsets. Further, results showed the need for investigati

Published
2016

31. The Italian MSUS Study Group Recommendations for the format and content of the report and documentation in MSUS in Rheumatology

Author

Iagnocco, A., Porta, F., Cuomo, G., Delle Sedie, A., Filippucci, E., Grassi, W., Sakellariou, G., Epis, O., Adinolfi, A., Ceccarelli, F., De Lucia, O., Di Geso, L., Di Sabatino, V., Gabba, A., Gattamelata, A., Gutierrez, M., Massaro, L., Massarotti, M., Perricone, C., Picerno, V., Ravagnani, V., Riente, Lucrezia, Scioscia, C., Naredo, E., and Filippou, G.

Published
2014

32. Evidence-based algorithm for diagnosis and assessment in psoriatic arthritis: results by Italian DElphi in psoriatic Arthritis (IDEA)

Author

Lapadula, G., primary, Marchesoni, A., additional, Salaffi, F., additional, Ramonda, R., additional, Salvarani, C., additional, Punzi, L., additional, Costa, L., additional, Caso, F., additional, Simone, D., additional, Baiocchi, G., additional, Scioscia, C., additional, Di Carlo, M., additional, Scarpa, R., additional, and Ferraccioli, G., additional

Published
2016
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33. OP0050 Serum Levels of Adipokines in The Categories of Body Mass Index (BMI) in Patients with Systemic Sclerosis

Author

Praino, E., primary, Rotondo, C., additional, Scioscia, C., additional, Anelli, M.G., additional, Chialà, A., additional, Coladonato, L., additional, Perniola, S., additional, Natuzzi, D., additional, Bruni, C., additional, Guiducci, S., additional, Matucci-Cerinic, M., additional, Lapadula, G., additional, and Iannone, F., additional

Published
2016
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34. AB0041 Serum Amyloid A Stimulates The Induction of Inflammatory Mediators in Monocytes from Behçet's Disease Patients: A Proof of Concept Study

Author

Lopalco, G., primary, Lucherini, O.M., additional, Cantarini, L., additional, Lopalco, A., additional, Vitale, A., additional, Venerito, V., additional, Chialà, A., additional, Fornaro, M., additional, Anelli, M.G., additional, Scioscia, C., additional, Cacciapaglia, F., additional, Natuzzi, D., additional, Lapadula, G., additional, and Iannone, F., additional

Published
2016
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36. SAT0061 Concurrent Ultrasound-Detected Synovitis and Tenosynovitis Predict Flare in Patients with Rheumatoid Arthritis in Clinical Remission

Author

Sakellariou, G., primary, Bellis, E., additional, Scirè, C.A., additional, Carrara, G., additional, Adinolfi, A., additional, Bortoluzzi, A., additional, Batticciotto, A., additional, Cagnotto, G., additional, Caprioli, M., additional, Canzoni, M., additional, Cavatorta, F.P., additional, De Lucia, O., additional, Di Sabatino, V., additional, Draghessi, A., additional, Filippou, G., additional, Farina, I., additional, Focherini, M.C., additional, Gabba, A., additional, Gutierrez, M., additional, Idolazzi, L., additional, Luccioli, F., additional, Macchioni, P., additional, Massarotti, M.S., additional, Mastaglio, C., additional, Menza, L., additional, Muratore, M., additional, Parisi, S., additional, Picerno, V., additional, Piga, M., additional, Ramonda, R., additional, Raffeiner, B., additional, Rossi, D., additional, Rossi, S., additional, Rossini, P., additional, Scioscia, C., additional, Venditti, C., additional, Volpe, A., additional, Matucci-Cerinic, M., additional, and Iagnocco, A., additional

Published
2016
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37. SAT0216 Chest Ultrasound Signs of Interstitial Lung Disease in Systemic Sclerosis Patients: A Comparison between High Resolution Chest Computed Tomography Findings

Author

Rotondo, C., primary, Chialà, A., additional, Nivuori, M., additional, Coladonato, L., additional, Giannini, M., additional, Anelli, M.G., additional, Righetti, G., additional, Scioscia, C., additional, Fiorentini, C., additional, Lopalco, G., additional, Lapadula, G., additional, and Iannone, F., additional

Published
2016
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39. L’uso dei farmaci biologici durante la gravidanza e l’allattamento

Author

Favalli, E. G., Mancarella, L., Paoletti, F., Pomponio, G., Sandri, Gilda, Scioscia, C., Selvi, E., Tirri, E., D’Errico, T., Epis, O., and Garau, P.

Subjects
Arthritis, rheumatoid - Pregnancy - Tumor necrosis factor-alpha - Etanercept - Monoclonal antibodies - Rituximab - Certolizumab - Tocilizumab - Abatacept - Disease-modifying antirheumatic drugs, Arthritis, rheumatoid - Pregnancy - Tumor necrosis factor-alpha - Etanercept - Monoclonal antibodies - Rituximab - Certolizumab - Tocilizumab - Abatacept - Disease-modifying antirheumatic drugs
Published
2012

40. Efficacia e sicurezza delle vaccinazioni anti-influenza e anti-pneumococco nei pazienti con artrite reumatoide trattati con farmaci biologici

Author

Pomponio, G., Rovinelli, M., Scioscia, C., Selvi, E., Tirri, E., D’Errico, T., Epis, O., Favalli, E. G., Garau, P., Mancarella, L., Paoletti, F., and Sandri, Gilda

Subjects
Arthritis, Arthritis, rheumatoid - Tumor necrosis factor-alpha - Influenza vaccines - Pneumococcal vaccines, rheumatoid - Tumor necrosis factor-alpha - Influenza vaccines - Pneumococcal vaccines
Published
2012

42. Reazioni cutanee e terapia con anti-TNF-α

Author

Mancarella, L., Meliconi, R., Sandri, Gilda, Scioscia, C., Selvi, E., Tirri, E., D’Errico, T., Epis, O., Favalli, E. G., Garau, P., Paoletti, F., and Pomponio, G.

Subjects
rheumatoid - Skin diseases - Psoriasis - Tumor necrosis factor-alpha, Arthritis, Arthritis, rheumatoid - Skin diseases - Psoriasis - Tumor necrosis factor-alpha
Published
2012

43. Farmaci biologici ed epatiti da virus B e C

Author

D’Errico, T., Tirri, E., Favalli, E. G., Garau, P., Mancarella, L., Paoletti, F., Pomponio, G., Sandri, Gilda, Scioscia, C., Selvi, E., and Epis, O.

Subjects
Arthritis, Arthritis, rheumatoid - Hepatitis B - Hepatitis C - Tumor necrosis factor-alpha - Antiviral agents, rheumatoid - Hepatitis B - Hepatitis C - Tumor necrosis factor-alpha - Antiviral agents
Published
2012

44. Farmaci biologici e tematiche relative alla cardiopatia ischemica e all’insufficienza cardiaca

Author

Garau, P., D’Errico, T., Epis, O., Favalli, E. G., Mancarella, L., Paoletti, F., Pomponio, G., Sandri, Gilda, Scioscia, C., Selvi, E., and Tirri, E.

Subjects
Arthritis, Arthritis, rheumatoid - Tumor necrosis factor-alpha - Cardiovascular diseases - Myocardial infarction - Heart failure, rheumatoid - Tumor necrosis factor-alpha - Cardiovascular diseases - Myocardial infarction - Heart failure
Published
2012

46. Farmaci biologici e rischio oncologico

Author

Sandri, Gilda, Paoletti, F., Pomponio, G., Scioscia, C., Selvi, E., Tirri, E., D’Errico, T., Epis, O., Favalli, E. G., Garau, P., and Mancarella, L.

Subjects
Arthritis, rheumatoid - Neoplasms - Lymphoma - Tumor necrosis factor-alpha, rheumatoid - Neoplasms - Lymphoma - Tumor necrosis factor-alpha, Arthritis
Published
2012

47. Farmaci biologici e infezione tubercolare

Author

Scioscia, C., Anelli, M. G., Epis, O., Favalli, E. G., Garau, P., Mancarella, L., Paoletti, F., Pomponio, G., Sandri, Gilda, Selvi, E., Tirri, E., and D’Errico, T.

Subjects
rheumatoid - Tumor necrosis factor-alpha - Antibodies, Arthritis, Arthritis, rheumatoid - Tumor necrosis factor-alpha - Antibodies, monoclonal - Tuberculosis, monoclonal - Tuberculosis
Published
2012

48. OP0217 Ultrasound-Detected Synovitis and Tenosynovitis Independently Associate with Flare in Patients with Rheumatoid Arthritis in Clinical Remission

Author

Bellis, E., primary, Scirè, C.A., additional, Carrara, G., additional, Adinolfi, A., additional, Batticciotto, A., additional, Bortoluzzi, A., additional, Cagnotto, G., additional, Caprioli, M., additional, Canzoni, M., additional, Cavatorta, F.P., additional, De Lucia, O., additional, Di Sabatino, V., additional, Draghessi, A., additional, Filippou, G., additional, Farina, I., additional, Focherini, M.C., additional, Gabba, A., additional, Gutierrez, M., additional, Idolazzi, L., additional, Luccioli, F., additional, Macchioni, P., additional, Massarotti, M.S., additional, Mastaglio, C., additional, Menza, L., additional, Muratore, M., additional, Parisi, S., additional, Picerno, V., additional, Piga, M., additional, Ramonda, R., additional, Raffeiner, B., additional, Rossi, D., additional, Rossi, S., additional, Rossini, P., additional, Sakellariou, G., additional, Scioscia, C., additional, Venditti, C., additional, Volpe, A., additional, Matucci-Cerinic, M., additional, and Iagnocco, A., additional

Published
2015
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50. AB0065 Possible Interplay Between Serum Amyloid-A and Pro-Inflammatory Cytokines Into the Pathogenesis of Behçet's Disease

Author

Lopalco, G., primary, Lucherini, O.M., additional, Cantarini, L., additional, Vitale, A., additional, Talarico, R., additional, Giannini, M., additional, Scioscia, C., additional, Anelli, M.G., additional, Cacciapaglia, F., additional, Natuzzi, D., additional, Bizzoca, R., additional, Perniola, S., additional, Lapadula, G., additional, and Iannone, F., additional

Published
2015
Full Text
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