Author: "Sciannameo, V." - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"Sciannameo, V."' showing total 95 results

Start Over Author "Sciannameo, V."

95 results on '"Sciannameo, V."'

1. Disease control of acromegaly does not prevent excess mortality in the long term: results of a nationwide survey in Italy

Author: Arosio, M., Sciannameo, V., Contarino, A., Berchialla, P., Puglisi, S., Pesatori, A. C., Ferrante, E., Filopanti, M., Pivonello, R., Dassie, F., Rochira, V., Cannavò, S., De Menis, E., Pigliaru, F., Grottoli, S., Cambria, V., Faustini-Fustini, M., Montini, M., Peri, A., Ceccato, F., Puxeddu, E., Borretta, G., Bondanelli, M., Ferone, D., Colao, A., Terzolo, M., and Reimondo, G.
Published: 2024
Full Text: View/download PDF

2. Pediatric injuries classification using openAI: new opportunities for epidemiological surveillance

Author: Lorenzoni, G, primary, Sciannameo, V, additional, Baldan, G A, additional, Bressan, S, additional, Da Dalt, L, additional, and Berchialla, P, additional
Published: 2023
Full Text: View/download PDF

3. Can atrophic‐erosive oral lichen planus promote cardiovascular diseases? A population‐based study

Author: Conrotto, D, Barattero, R, Carbone, M, Gambino, A, Sciannameo, V, Ricceri, F, Conrotto, F, Broccoletti, R, and Arduino, P‐G
Published: 2018
Full Text: View/download PDF

4. Problematic social media use: Associations with health complaints among adolescents

Author: Marino, C, Lenzi, M, Canale, N, Pierannunzio, D, Dalmasso, P, Borraccino, A, Cappello, N, Lemma, P, Vieno, A, Nardone, P, Spinelli, A, Donati, S, Pizzi, E, Ciardullo, S, Andreozzi, S, Bucciarelli, M, de Mei, B, Cattaneo, C, Cavallo, F, Piraccini, G, Berchialla, P, Charrier, L, Sciannameo, V, Gaboardi, M, Santinello, M, Lazzeri, G, Giacchi, M, Pammolli, A, Simi, R, Galeone, D, Menzano, M, Vienna, A, Colleluori, C, Di Giacomo, M, Ranalli, E, Cauzillo, G, Mininni, M, Sorrentino, G, Azzarito, C, Cernuzio, A, la Rocca, M, Pugliese, A, Mazzarella, G, Angelini, P, Fridel, M, Carletti, C, Concina, F, Ronfani, L, Pani, P, Cairella, G, Bosca, L, Pancallo, M, Ferrando, G, Celata, C, Coppola, L, Lobascio, C, Gelmi, G, Crottogini, L, Velasco, V, de Introna, S, Giostra, G, Ciallella, M, Colitti, M, Paolitto, E, Caputo, M, Stingi, D, Pacella, P, Pasquale, P, Palmas, M, Murgia, A, Cernigliaro, A, Ferro, M, Scondotto, S, Aramini, L, Corridori, V, Cristofori, M, Sorbelli, D, Giovannini, G, Covarino, A, Michieletto, F, Bino, E, Zuccali, M, Fanolla, A, Weiss, S, Marino C., Lenzi M., Canale N., Pierannunzio D., Dalmasso P., Borraccino A., Cappello N., Lemma P., Vieno A., Nardone P., Spinelli A., Donati S., Pizzi E., Ciardullo S., Andreozzi S., Bucciarelli M., de Mei B., Cattaneo C., Cavallo F., Piraccini G., Berchialla P., Charrier L., Sciannameo V., Gaboardi M., Santinello M., Lazzeri G., Giacchi M. V., Pammolli A., Simi R., Galeone D., Menzano M. T., Vienna A., Colleluori C., Di Giacomo M., Ranalli E., Cauzillo G., Mininni M., Sorrentino G., Azzarito C., Cernuzio A., la Rocca M., Pugliese A., Mazzarella G., Angelini P., Fridel M., Carletti C., Concina F., Ronfani L., Pani P., Cairella G., Bosca L., Pancallo M. T., Ferrando G., Celata C., Coppola L., Lobascio C., Gelmi G., Crottogini L., Velasco V., de Introna S., Giostra G., Ciallella M. L., Colitti M., Paolitto E., Caputo M., Stingi D., Pacella P., Pasquale P., Palmas M. A., Murgia A., Cernigliaro A., Ferro M. P., Scondotto S., Aramini L., Corridori V., Cristofori M., Sorbelli D., Giovannini G., Covarino A. M., Michieletto F., Bino E., Zuccali M. G., Fanolla A., Weiss S., Marino, C, Lenzi, M, Canale, N, Pierannunzio, D, Dalmasso, P, Borraccino, A, Cappello, N, Lemma, P, Vieno, A, Nardone, P, Spinelli, A, Donati, S, Pizzi, E, Ciardullo, S, Andreozzi, S, Bucciarelli, M, de Mei, B, Cattaneo, C, Cavallo, F, Piraccini, G, Berchialla, P, Charrier, L, Sciannameo, V, Gaboardi, M, Santinello, M, Lazzeri, G, Giacchi, M, Pammolli, A, Simi, R, Galeone, D, Menzano, M, Vienna, A, Colleluori, C, Di Giacomo, M, Ranalli, E, Cauzillo, G, Mininni, M, Sorrentino, G, Azzarito, C, Cernuzio, A, la Rocca, M, Pugliese, A, Mazzarella, G, Angelini, P, Fridel, M, Carletti, C, Concina, F, Ronfani, L, Pani, P, Cairella, G, Bosca, L, Pancallo, M, Ferrando, G, Celata, C, Coppola, L, Lobascio, C, Gelmi, G, Crottogini, L, Velasco, V, de Introna, S, Giostra, G, Ciallella, M, Colitti, M, Paolitto, E, Caputo, M, Stingi, D, Pacella, P, Pasquale, P, Palmas, M, Murgia, A, Cernigliaro, A, Ferro, M, Scondotto, S, Aramini, L, Corridori, V, Cristofori, M, Sorbelli, D, Giovannini, G, Covarino, A, Michieletto, F, Bino, E, Zuccali, M, Fanolla, A, Weiss, S, Marino C., Lenzi M., Canale N., Pierannunzio D., Dalmasso P., Borraccino A., Cappello N., Lemma P., Vieno A., Nardone P., Spinelli A., Donati S., Pizzi E., Ciardullo S., Andreozzi S., Bucciarelli M., de Mei B., Cattaneo C., Cavallo F., Piraccini G., Berchialla P., Charrier L., Sciannameo V., Gaboardi M., Santinello M., Lazzeri G., Giacchi M. V., Pammolli A., Simi R., Galeone D., Menzano M. T., Vienna A., Colleluori C., Di Giacomo M., Ranalli E., Cauzillo G., Mininni M., Sorrentino G., Azzarito C., Cernuzio A., la Rocca M., Pugliese A., Mazzarella G., Angelini P., Fridel M., Carletti C., Concina F., Ronfani L., Pani P., Cairella G., Bosca L., Pancallo M. T., Ferrando G., Celata C., Coppola L., Lobascio C., Gelmi G., Crottogini L., Velasco V., de Introna S., Giostra G., Ciallella M. L., Colitti M., Paolitto E., Caputo M., Stingi D., Pacella P., Pasquale P., Palmas M. A., Murgia A., Cernigliaro A., Ferro M. P., Scondotto S., Aramini L., Corridori V., Cristofori M., Sorbelli D., Giovannini G., Covarino A. M., Michieletto F., Bino E., Zuccali M. G., Fanolla A., and Weiss S.
Abstract: Objective. Problematic Social Media Use (PSMU) has an addictive potential for young users. The aim of this study was to show the prevalence of PSMU across Italian regions and its association with health complaints. Materials and methods. Data are gathered from the Italian 2018 Health Behaviour in School-aged Children survey using a representative sample of Italian adolescents aged 11, 13 and 15 years (50.6% males). Participants completed self-administered questionnaires assessing PSMU and health complaints. Results. PSMU affects 8.9% adolescents in Italy and the prevalence is quite consistent across regions. 13-year-olds girls showed the highest percentage of PSMU (13%). Problematic users of social media are more likely to report multiple somatic (OR = 1.84 [95% CI 1.82-1.85]) and psychological (OR = 2.60 [95% CI 2.58-2.63]) symptoms. Conclusions. PSMU represents a widespread problem in Italy. National prevention interventions are needed in order to promote a positive use of social media.
Published: 2020

5. Dietary habits among Italian adolescents and their relation to socio-demographic characteristics

Author: Nardone, P, Pierannunzio, D, Ciardullo, S, Lazzeri, G, Cappello, N, Spinelli, A, Donati, S, Pizzi, E, Andreozzi, S, Bucciarelli, M, de Mei, B, Cattaneo, C, Cavallo, F, Piraccini, G, Berchialla, P, Borraccino, A, Charrier, L, Dalmasso, P, Lemma, P, Sciannameo, V, Vieno, A, Canale, N, Gaboardi, M, Lenzi, M, Marino, C, Santinello, M, Giacchi, M, Pammolli, A, Simi, R, Galeone, D, Menzano, M, Vienna, A, Colleluori, C, Di Giacomo, M, Ranalli, E, Cauzillo, G, Mininni, M, Sorrentino, G, Azzarito, C, Cernuzio, A, la Rocca, M, Pugliese, A, Mazzarella, G, Angelini, P, Fridel, M, Carletti, C, Concina, F, Ronfani, L, Pani, P, Cairella, G, Bosca, L, Pancallo, M, Ferrando, G, Celata, C, Coppola, L, Lobascio, C, Gelmi, G, Crottogini, L, Velasco, V, de Introna, S, Giostra, G, Ciallella, M, Colitti, M, Paolitto, E, Caputo, M, Stingi, D, Pacella, P, Pasquale, P, Palmas, M, Murgia, A, Cernigliaro, A, Ferro, M, Scondotto, S, Aramini, L, Corridori, V, Cristofori, M, Sorbelli, D, Giovannini, G, Covarino, A, Michieletto, F, Bino, E, Zuccali, M, Fanolla, A, Weiss, S, Nardone P., Pierannunzio D., Ciardullo S., Lazzeri G., Cappello N., Spinelli A., Donati S., Pizzi E., Andreozzi S., Bucciarelli M., de Mei B., Cattaneo C., Cavallo F., Piraccini G., Berchialla P., Borraccino A., Charrier L., Dalmasso P., Lemma P., Sciannameo V., Vieno A., Canale N., Gaboardi M., Lenzi M., Marino C., Santinello M., Giacchi M. V., Pammolli A., Simi R., Galeone D., Menzano M. T., Vienna A., Colleluori C., Di Giacomo M., Ranalli E., Cauzillo G., Mininni M., Sorrentino G., Azzarito C., Cernuzio A., la Rocca M., Pugliese A., Mazzarella G., Angelini P., Fridel M., Carletti C., Concina F., Ronfani L., Pani P., Cairella G., Bosca L., Pancallo M. T., Ferrando G., Celata C., Coppola L., Lobascio C., Gelmi G., Crottogini L., Velasco V., de Introna S., Giostra G., Ciallella M. L., Colitti M., Paolitto E., Caputo M., Stingi D., Pacella P., Pasquale P., Palmas M. A., Murgia A., Cernigliaro A., Ferro M. P., Scondotto S., Aramini L., Corridori V., Cristofori M., Sorbelli D., Giovannini G., Covarino A. M., Michieletto F., Bino E., Zuccali M. G., Fanolla A., Weiss S., Nardone, P, Pierannunzio, D, Ciardullo, S, Lazzeri, G, Cappello, N, Spinelli, A, Donati, S, Pizzi, E, Andreozzi, S, Bucciarelli, M, de Mei, B, Cattaneo, C, Cavallo, F, Piraccini, G, Berchialla, P, Borraccino, A, Charrier, L, Dalmasso, P, Lemma, P, Sciannameo, V, Vieno, A, Canale, N, Gaboardi, M, Lenzi, M, Marino, C, Santinello, M, Giacchi, M, Pammolli, A, Simi, R, Galeone, D, Menzano, M, Vienna, A, Colleluori, C, Di Giacomo, M, Ranalli, E, Cauzillo, G, Mininni, M, Sorrentino, G, Azzarito, C, Cernuzio, A, la Rocca, M, Pugliese, A, Mazzarella, G, Angelini, P, Fridel, M, Carletti, C, Concina, F, Ronfani, L, Pani, P, Cairella, G, Bosca, L, Pancallo, M, Ferrando, G, Celata, C, Coppola, L, Lobascio, C, Gelmi, G, Crottogini, L, Velasco, V, de Introna, S, Giostra, G, Ciallella, M, Colitti, M, Paolitto, E, Caputo, M, Stingi, D, Pacella, P, Pasquale, P, Palmas, M, Murgia, A, Cernigliaro, A, Ferro, M, Scondotto, S, Aramini, L, Corridori, V, Cristofori, M, Sorbelli, D, Giovannini, G, Covarino, A, Michieletto, F, Bino, E, Zuccali, M, Fanolla, A, Weiss, S, Nardone P., Pierannunzio D., Ciardullo S., Lazzeri G., Cappello N., Spinelli A., Donati S., Pizzi E., Andreozzi S., Bucciarelli M., de Mei B., Cattaneo C., Cavallo F., Piraccini G., Berchialla P., Borraccino A., Charrier L., Dalmasso P., Lemma P., Sciannameo V., Vieno A., Canale N., Gaboardi M., Lenzi M., Marino C., Santinello M., Giacchi M. V., Pammolli A., Simi R., Galeone D., Menzano M. T., Vienna A., Colleluori C., Di Giacomo M., Ranalli E., Cauzillo G., Mininni M., Sorrentino G., Azzarito C., Cernuzio A., la Rocca M., Pugliese A., Mazzarella G., Angelini P., Fridel M., Carletti C., Concina F., Ronfani L., Pani P., Cairella G., Bosca L., Pancallo M. T., Ferrando G., Celata C., Coppola L., Lobascio C., Gelmi G., Crottogini L., Velasco V., de Introna S., Giostra G., Ciallella M. L., Colitti M., Paolitto E., Caputo M., Stingi D., Pacella P., Pasquale P., Palmas M. A., Murgia A., Cernigliaro A., Ferro M. P., Scondotto S., Aramini L., Corridori V., Cristofori M., Sorbelli D., Giovannini G., Covarino A. M., Michieletto F., Bino E., Zuccali M. G., Fanolla A., and Weiss S.
Abstract: Objective. The aim is to describe dietary habits and their association with socio-demographic characteristics in a large nationally representative sample of Italian adolescents aged 11, 13 and 15 years. Materials and methods. Data from the 2018 Italian Health Behaviour in School-aged Children (HBSC) survey on 58,976 adolescents were analysed to determine eating habits. Logistic regression was used to investigate the association between incorrect dietary habits and potential predictors. Results. 38.3% of boys and 48.1% of girls skipped breakfast and 54.1% did not consume fruit and/or vegetables daily. 15.9% of boys and 11.3% of girls drank carbonated-sugary beverages at least once a day. Incorrect dietary habits were more common among boys, adolescents with lower socio-economic conditions, residents in Southern Italy and those spending more time watching TV. Italian adolescents were more likely to have incorrect dietary habits compared with those from most other countries involved in 2018 HBSC. Conclusions. Action is needed to improve dietary habits among adolescents.
Published: 2020

6. Exploring the Use and Usefulness of Educational Resources Among Nurses During the First Wave of the COVID-19 Pandemic: A Cross-Sectional Study

Author: Conti, A, Clari, M, Luciani, M, Sciannameo, V, Berchialla, P, Dimonte, V, Campagna, S, Conti, A, Clari, M, Luciani, M, Sciannameo, V, Berchialla, P, Dimonte, V, and Campagna, S
Abstract: Nurses needed to learn rapidly how to care for patients with coronavirus disease 2019 (COVID-19). This cross-sectional study identified the educational resources RNs used to learn how to care for these patients, measured the perceived usefulness of the content of these resources, and explored the most relevant educational content sought during the first wave of the pandemic. A total of 799 RNs completed an online survey. Significant differences were found in the educational resources used between RNs who cared for patients with COVID-19 and RNs who did not, as well as for RNs who changed units following the pandemic. The educational resources most often used were also ranked as most useful. The most relevant educational content sought was related to respiratory care techniques and infection containment. These findings provide insight into the educational resources available during the first wave of the COVID-19 pandemic. They could help in developing educational programs relevant to nurses' needs during future pandemics. [J Contin Educ Nurs. 2022;53(2):63-69.].
Published: 2022

7. Problematic social media use: Associations with health complaints among adolescents

Author: Marino, C., Lenzi, M., Canale, N., Pierannunzio, D., Dalmasso, P., Borraccino, A., Cappello, N., Lemma, P., Vieno, A., Nardone, P., Spinelli, A., Donati, S., Pizzi, E., Ciardullo, S., Andreozzi, S., Bucciarelli, M., de Mei, B., Cattaneo, C., Cavallo, F., Piraccini, G., Berchialla, P., Charrier, L., Sciannameo, V., Gaboardi, M., Santinello, M., Lazzeri, G., Giacchi, M. V., Pammolli, A., Simi, R., Galeone, D., Menzano, M. T., Vienna, A., Colleluori, C., Di Giacomo, M., Ranalli, E., Cauzillo, G., Mininni, M., Sorrentino, G., Azzarito, C., Cernuzio, A., la Rocca, M., Pugliese, A., Mazzarella, G., Angelini, P., Fridel, M., Carletti, C., Concina, F., Ronfani, L., Pani, P., Cairella, G., Bosca, L., Pancallo, M. T., Ferrando, G., Celata, C., Coppola, L., Lobascio, C., Gelmi, G., Crottogini, L., Velasco, V., de Introna, S., Giostra, G., Ciallella, M. L., Colitti, M., Paolitto, E., Caputo, M., Stingi, D., Pacella, P., Pasquale, P., Palmas, M. A., Murgia, A., Cernigliaro, A., Ferro, M. P., Scondotto, S., Aramini, L., Corridori, V., Cristofori, M., Sorbelli, D., Giovannini, G., Covarino, A. M., Michieletto, F., Bino, E., Zuccali, M. G., Fanolla, A., Weiss, S., Marino, C, Lenzi, M, Canale, N, Pierannunzio, D, Dalmasso, P, Borraccino, A, Cappello, N, Lemma, P, Vieno, A, Nardone, P, Spinelli, A, Donati, S, Pizzi, E, Ciardullo, S, Andreozzi, S, Bucciarelli, M, de Mei, B, Cattaneo, C, Cavallo, F, Piraccini, G, Berchialla, P, Charrier, L, Sciannameo, V, Gaboardi, M, Santinello, M, Lazzeri, G, Giacchi, M, Pammolli, A, Simi, R, Galeone, D, Menzano, M, Vienna, A, Colleluori, C, Di Giacomo, M, Ranalli, E, Cauzillo, G, Mininni, M, Sorrentino, G, Azzarito, C, Cernuzio, A, la Rocca, M, Pugliese, A, Mazzarella, G, Angelini, P, Fridel, M, Carletti, C, Concina, F, Ronfani, L, Pani, P, Cairella, G, Bosca, L, Pancallo, M, Ferrando, G, Celata, C, Coppola, L, Lobascio, C, Gelmi, G, Crottogini, L, Velasco, V, de Introna, S, Giostra, G, Ciallella, M, Colitti, M, Paolitto, E, Caputo, M, Stingi, D, Pacella, P, Pasquale, P, Palmas, M, Murgia, A, Cernigliaro, A, Ferro, M, Scondotto, S, Aramini, L, Corridori, V, Cristofori, M, Sorbelli, D, Giovannini, G, Covarino, A, Michieletto, F, Bino, E, Zuccali, M, Fanolla, A, and Weiss, S
Subjects: Male, Adolescent, Problematic use, Psychosomatic symptom, Adolescence, Social media, Cross-Sectional Studies, Italy, Psychosomatic symptoms, Child, Female, Humans, Internet Addiction Disorder, Prevalence, Self Report, Social Media
Abstract: Objective. Problematic Social Media Use (PSMU) has an addictive potential for young users. The aim of this study was to show the prevalence of PSMU across Italian regions and its association with health complaints. Materials and methods. Data are gathered from the Italian 2018 Health Behaviour in School-aged Children survey using a representative sample of Italian adolescents aged 11, 13 and 15 years (50.6% males). Participants completed self-administered questionnaires assessing PSMU and health complaints. Results. PSMU affects 8.9% adolescents in Italy and the prevalence is quite consistent across regions. 13-year-olds girls showed the highest percentage of PSMU (13%). Problematic users of social media are more likely to report multiple somatic (OR = 1.84 [95% CI 1.82-1.85]) and psychological (OR = 2.60 [95% CI 2.58-2.63]) symptoms. Conclusions. PSMU represents a widespread problem in Italy. National prevention interventions are needed in order to promote a positive use of social media.
Published: 2020

8. Dietary habits among Italian adolescents and their relation to socio-demographic characteristics

Author: Nardone P., Pierannunzio D., Ciardullo S., Lazzeri G., Cappello N., Spinelli A., Donati S., Pizzi E., Andreozzi S., Bucciarelli M., de Mei B., Cattaneo C., Cavallo F., Piraccini G., Berchialla P., Borraccino A., Charrier L., Dalmasso P., Lemma P., Sciannameo V., Vieno A., Canale N., Gaboardi M., Lenzi M., Marino C., Santinello M., Giacchi M. V., Pammolli A., Simi R., Galeone D., Menzano M. T., Vienna A., Colleluori C., Di Giacomo M., Ranalli E., Cauzillo G., Mininni M., Sorrentino G., Azzarito C., Cernuzio A., la Rocca M., Pugliese A., Mazzarella G., Angelini P., Fridel M., Carletti C., Concina F., Ronfani L., Pani P., Cairella G., Bosca L., Pancallo M. T., Ferrando G., Celata C., Coppola L., Lobascio C., Gelmi G., Crottogini L., Velasco V., de Introna S., Giostra G., Ciallella M. L., Colitti M., Paolitto E., Caputo M., Stingi D., Pacella P., Pasquale P., Palmas M. A., Murgia A., Cernigliaro A., Ferro M. P., Scondotto S., Aramini L., Corridori V., Cristofori M., Sorbelli D., Giovannini G., Covarino A. M., Michieletto F., Bino E., Zuccali M. G., Fanolla A., Weiss S., Nardone, P, Pierannunzio, D, Ciardullo, S, Lazzeri, G, Cappello, N, Spinelli, A, Donati, S, Pizzi, E, Andreozzi, S, Bucciarelli, M, de Mei, B, Cattaneo, C, Cavallo, F, Piraccini, G, Berchialla, P, Borraccino, A, Charrier, L, Dalmasso, P, Lemma, P, Sciannameo, V, Vieno, A, Canale, N, Gaboardi, M, Lenzi, M, Marino, C, Santinello, M, Giacchi, M, Pammolli, A, Simi, R, Galeone, D, Menzano, M, Vienna, A, Colleluori, C, Di Giacomo, M, Ranalli, E, Cauzillo, G, Mininni, M, Sorrentino, G, Azzarito, C, Cernuzio, A, la Rocca, M, Pugliese, A, Mazzarella, G, Angelini, P, Fridel, M, Carletti, C, Concina, F, Ronfani, L, Pani, P, Cairella, G, Bosca, L, Pancallo, M, Ferrando, G, Celata, C, Coppola, L, Lobascio, C, Gelmi, G, Crottogini, L, Velasco, V, de Introna, S, Giostra, G, Ciallella, M, Colitti, M, Paolitto, E, Caputo, M, Stingi, D, Pacella, P, Pasquale, P, Palmas, M, Murgia, A, Cernigliaro, A, Ferro, M, Scondotto, S, Aramini, L, Corridori, V, Cristofori, M, Sorbelli, D, Giovannini, G, Covarino, A, Michieletto, F, Bino, E, Zuccali, M, Fanolla, A, and Weiss, S
Subjects: Male, vegetables, eating behaviour, Adolescent, breakfast, Feeding Behavior, fruit, Cross-Sectional Studies, beverage, Italy, Socioeconomic Factors, Humans, Female, Child, Demography
Abstract: Objective. The aim is to describe dietary habits and their association with socio-demographic characteristics in a large nationally representative sample of Italian adolescents aged 11, 13 and 15 years. Materials and methods. Data from the 2018 Italian Health Behaviour in School-aged Children (HBSC) survey on 58,976 adolescents were analysed to determine eating habits. Logistic regression was used to investigate the association between incorrect dietary habits and potential predictors. Results. 38.3% of boys and 48.1% of girls skipped breakfast and 54.1% did not consume fruit and/or vegetables daily. 15.9% of boys and 11.3% of girls drank carbonated-sugary beverages at least once a day. Incorrect dietary habits were more common among boys, adolescents with lower socio-economic conditions, residents in Southern Italy and those spending more time watching TV. Italian adolescents were more likely to have incorrect dietary habits compared with those from most other countries involved in 2018 HBSC. Conclusions. Action is needed to improve dietary habits among adolescents.
Published: 2020

9. Transposition of cardiovascular outcome trial effects to the real-world population of patients with type 2 diabetes

Author: Sciannameo, V., Berchialla, P., Avogaro, A., Fadini, G. P., DARWIN-T2D Network: Agostino Consoli, Gloria, Formoso, Giovanni, Grossi, Achiropita, Pucci, Giorgio, Sesti, Francesco, Andreozzi, Giuseppe, Capobianco, Adriano, Gatti, Riccardo, Bonadonna, Ivana, Zavaroni, Alessandra, Deicas, Giuseppe, Felace, Patrizia Li Volsi, Raffaella, Buzzetti, Gaetano, Leto, Gian Pio Sorice, Paola, D'Angelo, Susanna, Morano, Antonio Carlo Bossi, Edoardo, Duratorre, Ivano, Franzetti, Paola Silvia Morpurgo, Emanuela, Orsi, Fabrizio, Querci, Massimo, Boemi, Federica, D'Angelo, Massimiliano, Petrelli, Gianluca, Aimaretti, Ioannis, Karamouzis, Franco, Cavalot, Giuseppe, Saglietti, Giuliana, Cazzetta, Silvestre, Cervone, Eleonora, Devangelio, Olga, Lamacchia, Salvatore, Arena, Antonino Di Benedetto, Frittitta, Lucia, Carla, Giordano, Piro, Salvatore, Manfredi, Rizzo, Roberta, Chianetta, Carlo, Mannina, Roberto, Anichini, Giuseppe, Penno, Anna, Solini, Bruno, Fattor, Enzo, Bonora, Massimo, Cigolini, Annunziata, Lapolla, Nino Cristiano Chilelli, Natalino, Simioni, Vera, Frison, and Carmela, Vinci.
Subjects: Male, medicine.medical_specialty, Time Factors, Databases, Factual, Endocrinology, Diabetes and Metabolism, Clinical Decision-Making, Population, Type 2 diabetes, Disease, Risk Assessment, Risk Factors, Internal medicine, Diabetes mellitus, Prevalence, medicine, Humans, Hypoglycemic Agents, Diseases of the circulatory (Cardiovascular) system, education, Original Investigation, Aged, Retrospective Studies, Angiology, Clinical Trials as Topic, education.field_of_study, business.industry, cardiovascular outcome, DPP-4 inhibitors, type 2 diabetes (T2D), Hazard ratio, Age Factors, Middle Aged, medicine.disease, Confidence interval, Treatment Outcome, Diabetes Mellitus, Type 2, Italy, Cardiovascular Diseases, Research Design, RC666-701, Female, Cardiology and Cardiovascular Medicine, business, Mace
Abstract: Background Transferring results obtained in cardiovascular outcome trials (CVOTs) to the real-world setting is challenging. We herein transposed CVOT results to the population of patients with type 2 diabetes (T2D) seen in routine clinical practice and who may receive the medications tested in CVOTs. Methods We implemented the post-stratification approach based on aggregate data of CVOTs and individual data of a target population of diabetic outpatients. We used stratum-specific estimates available from CVOTs to calculate expected effect size for the target population by weighting the average of the stratum-specific treatment effects according to proportions of a given characteristic in the target population. Data are presented as hazard ratio (HR) and 95% confidence intervals. Results Compared to the target population (n = 139,708), the CVOT population (n = 95,816) was younger and had a two to threefold greater prevalence of cardiovascular disease. EMPA-REG was the CVOT with the largest variety of details on stratum-specific effects, followed by TECOS, whereas DECLARE and PIONEER-6 had more limited stratum-specific information. The post-stratification HR estimate for 3 point major adverse cardiovascular event (MACE) based on EMPA-REG was 0.88 (0.74–1.03) in the target population, compared to 0.86 (0.74–0.99) in the trial. The HR estimate based on LEADER was 0.88 (0.77–0.99) in the target population compared to 0.87 (0.78–0.97) in the trial. Consistent results were obtained for SUSTAIN-6, EXSCEL, PIONEER-6 and DECLARE. The effect of DPP-4 inhibitors observed in CVOTs remained neutral in the target population. Conclusions Based on CVOT stratum-specific effects, cardiovascular protective actions of glucose lowering medications tested in CVOTs are transferrable to a much different real-world population of patients with T2D.
Published: 2021

10. The Impact of the COVID-19 Pandemic on Nursing Care: A Cross-Sectional Survey-Based Study

Author: Clari, M, Luciani, M, Conti, A, Sciannameo, V, Berchialla, P, Di Giulio, P, Campagna, S, Dimonte, V, Clari, Marco, Luciani, Michela, Conti, Alessio, Sciannameo, Veronica, Berchialla, Paola, Di Giulio, Paola, Campagna, Sara, Dimonte, Valerio, Clari, M, Luciani, M, Conti, A, Sciannameo, V, Berchialla, P, Di Giulio, P, Campagna, S, Dimonte, V, Clari, Marco, Luciani, Michela, Conti, Alessio, Sciannameo, Veronica, Berchialla, Paola, Di Giulio, Paola, Campagna, Sara, and Dimonte, Valerio
Abstract: The COVID-19 pandemic has had a severe impact on nursing care. This cross-sectional survey-based study compared aspects of nursing care and nurses’ satisfaction with care provided before and during the first wave of the COVID-19 pandemic. A total of 936 registered nurses (RNs) rated the frequency with which they performed fundamental care, nursing techniques, patient education, symptom management, and nurse–patient relationships before and during the pandemic. A recursive partitioning for ordered multivariate response in a conditional inference framework approach was applied. More frequent fundamental cares were associated with their frequency before the pandemic (p < 0.001), caring for COVID-19 patients (p < 0.001), and workplace reassignment (p = 0.004). Caring for COVID-19 patients (p < 0.001), workplace reassignment (p = 0.030), and caring for ≤7.4 COVID-19 patients (p = 0.014) increased nursing techniques. RNs in high-intensity COVID-19 units (p = 0.002) who educated patients before the pandemic, stopped this task. RNs caring for COVID-19 patients reported increased symptom management (p < 0.001), as did RNs caring for more non-COVID-19 patients (p = 0.037). Less frequent nurse–patient relationships before the pandemic and working in high-intensity COVID-19 units decreased nurse–patient relationships (p = 0.002). Despite enormous challenges, nurses continued to provide a high level of care. Ensuring the appropriate deployment and education of nurses is crucial to personalize care and to maintain nurses’ satisfaction with the care provided.
Published: 2021

11. Similar effectiveness of dapagliflozin and GLP-1 receptor agonists concerning combined endpoints in routine clinical practice: A multicentre retrospective study

Author: Fadini, G. P., Sciannameo, V., Franzetti, I., Bottigliengo, D., D'Angelo, P., Vinci, C., Berchialla, P., Arena, S., Buzzetti, R., Avogaro, A., Consoli, A., Formoso, G., Grossi, G., Pucci, A., Sesti, G., Andreozzi, F., Capobianco, G., Gatti, A., Bonadonna, R., Zavaroni, I., Cas, A. D., Felace, G., Volsi, P. L., Leto, G., Sorice, G. P., Morano, S., Bossi, A. C., Duratorre, E., Morpurgo, P. S., Orsi, E., Querci, F., Boemi, M., D'Angelo, F., Petrelli, M., Aimaretti, G., Karamouzis, I., Cavalot, F., Saglietti, G., Cazzetta, G., Cervone, S., Devangelio, E., Lamacchia, O., Di Benedetto, A., Frittitta, L., Giordano, C., Piro, S., Rizzo, M., Chianetta, R., Mannina, C., Anichini, R., Penno, G., Solini, A., Fattor, B., Bonora, E., Cigolini, M., Lapolla, A., Chilelli, N. C., Poli, M., Simioni, N., Frison, V., Fadini G.P., Sciannameo V., Franzetti I., Bottigliengo D., D'Angelo P., Vinci C., Berchialla P., Arena S., Buzzetti R., Avogaro A., Consoli A., Formoso G., Grossi G., Pucci A., Sesti G., Andreozzi F., Capobianco G., Gatti A., Bonadonna R., Zavaroni I., Cas A.D., Felace G., Volsi P.L., Leto G., Sorice G.P., Morano S., Bossi A.C., Duratorre E., Morpurgo P.S., Orsi E., Querci F., Boemi M., D'Angelo F., Petrelli M., Aimaretti G., Karamouzis I., Cavalot F., Saglietti G., Cazzetta G., Cervone S., Devangelio E., Lamacchia O., Di Benedetto A., Frittitta L., Giordano C., Piro S., Rizzo M., Chianetta R., Mannina C., Anichini R., Penno G., Solini A., Fattor B., Bonora E., Cigolini M., Lapolla A., Chilelli N.C., Poli M., Simioni N., and Frison V.
Subjects: Blood Glucose, Male, Glycated Hemoglobin A, Endocrinology, Diabetes and Metabolism, Blood Pressure, Type 2 diabetes, 030204 cardiovascular system & hematology, Settore MED/13 - Endocrinologia, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Glucosides, Clinical endpoint, Medicine, Dapagliflozin, GLP-1 analogue, Middle Aged, Treatment Outcome, glycaemic control, antidiabetic drug, dapagliflozin, observational study, Combination, Original Article, Drug Therapy, Combination, Female, Type 2, medicine.drug, Adult, medicine.medical_specialty, 030209 endocrinology & metabolism, Glucagon-Like Peptide-1 Receptor, 03 medical and health sciences, Drug Therapy, GLP‐1 analogue, Internal medicine, Diabetes mellitus, Internal Medicine, Diabetes Mellitus, Humans, Hypoglycemic Agents, Benzhydryl Compounds, Aged, Retrospective Studies, Glycated Hemoglobin, Body Weight, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Exenatide, Liraglutide, business.industry, Retrospective cohort study, Original Articles, medicine.disease, Blood pressure, chemistry, Propensity score matching, business, Antidiabetic drug, dapagliflozin, GLP-1 analogue, glycaemic control, observational study
Abstract: Aims According to cardiovascular outcome trials, some sodium‐glucose contransporter‐2 inhibitors (SGLT2i) and glucagon‐like peptide‐1 receptor agonists (GLP‐1RA) are recommended for secondary cardiovascular prevention in type 2 diabetes (T2D). In this real‐world study, we compared the simultaneous reductions in HbA1c, body weight and systolic blood pressure after initiation of dapagliflozin or GLP‐1RA as second or a more advanced line of therapy. Materials and methods DARWIN‐T2D was a retrospective multi‐centre study conducted at diabetes specialist clinics in Italy that compared T2D patients who initiated dapagliflozin or GLP‐1RA (exenatide once weekly or liraglutide). Data were collected at baseline and at the first follow‐up visit after 3 to 12 months. The primary endpoint was the proportion of patients achieving a simultaneous reduction in HbA1c, body weight and systolic blood pressure. To reduce confounding, we used multivariable adjustment (MVA) or propensity score matching (PSM). Results Totals of 473 patients initiating dapagliflozin and 336 patients initiating GLP‐1RA were included. The two groups differed in age, diabetes duration, HbA1c, weight and concomitant medications. The median follow‐up was 6 months in both groups. Using MVA or PSM, the primary endpoint was observed in 30% to 32% of patients, with no difference between groups. Simultaneous reduction of HbA1c, BP and SBP by specific threshold, as well as achievement of final goals, did not differ between groups. GLP‐1RA reduced HbA1c by 0.3% more than the reduction achieved with dapagliflozin. Conclusion In routine specialist care, initiation of dapagliflozin can be as effective as initiation of a GLP‐1RA for attainment of combined risk factor goals.
Published: 2019

12. Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition

Author: Obón-Santacana, M., Luján-Barroso, L., Freisling, H., Naudin, S., Boutron-Ruault, M.-C., Mancini, F.R., Rebours, V., Kühn, T., Katzke, V., Boeing, H., Tjønneland, A., Olsen, A., Overvad, K., Lasheras, C., Rodríguez-Barranco, M., Amiano, P., Santiuste, C., Ardanaz, E., Khaw, K.-T., Wareham, N.J., Aune, D., Trichopoulou, A., Thriskos, P., Peppa, E., Masala, G., Grioni, S., Tumino, R., Panico, S., Bueno-de-Mesquita, B., Sciannameo, V., Vermeulen, R., Sonestedt, E., Sund, M., Weiderpass, E., Skeie, G., Riboli, E., Duell, E.J., IRAS OH Epidemiology Chemical Agents, and dIRAS RA-2
Subjects: prospective cohort study, pancreatic cancer, nuts, seeds, diet, EPIC, intake
Abstract: Four epidemiologic studies have assessed the association between nut intake and pancreatic cancer risk with contradictory results. The present study aims to investigate the relation between nut intake (including seeds) and pancreatic ductal adenocarcinoma (PDAC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to estimate hazards ratio (HR) and 95% confidence intervals (95% CI) for nut intake and PDAC risk. Information on intake of nuts was obtained from the EPIC country-specific dietary questionnaires. After a mean follow-up of 14 years, 476,160 participants were eligible for the present study and included 1,283 PDAC cases. No association was observed between consumption of nuts and PDAC risk (highest intake vs nonconsumers: HR, 0.89; 95% CI, 0.72–1.10; p-trend = 0.70). Furthermore, no evidence for effect-measure modification was observed when different subgroups were analyzed. Overall, in EPIC, the highest intake of nuts was not statistically significantly associated with PDAC risk.
Published: 2020

13. Menstrual factors, reproductive history, hormone use, and urothelial carcinoma risk: a prospective study in the EPIC cohort

Author: Lujan-Barroso, L. Botteri, E. Caini, S. Ljungberg, B.F. Roswall, N. Tjønneland, A. Bueno-De-Mesquita, B. Gram, I.T. Tumino, R. Kiemeney, L.A. Liedberg, F. Stocks, T. Gunter, M.J. Murphy, N. Cervenka, I. Fournier, A. Kvaskoff, M. Haggstrom, C. Overvad, K. Lund, E. Waaseth, M. Fortner, R.T. Kuhn, T. Menendez, V. Sanchez, M.-J. Santiuste, C. Perez-Cornago, A. Zamora-Ros, R. Cross, A.J. Trichopoulou, A. Karakatsani, A. Peppa, E. Palli, D. Krogh, V. Sciannameo, V. Mattiello, A. Panico, S. van Gils, C.H. Charlotte Onland-Moret, N. Barricarte, A. Amiano, P. Khaw, K.-T. Boeing, H. Weiderpass, E. Duell, E.J.
Abstract: Background: Urothelial carcinoma is the predominant (95%) bladder cancer subtype in industrialized nations. Animal and epidemiologic human studies suggest that hormonal factors may influence urothelial carcinoma risk. Methods: We used an analytic cohort of 333,919 women from the European Prospective Investigation into Cancer and Nutrition Cohort. Associations between hormonal factors and incident urothelial carcinoma (overall and by tumor grade, tumor aggressiveness, and non–muscle-invasive urothelial carcinoma) risk were evaluated using Cox proportional hazards models. Results: During a mean of 15 years of follow-up, 529 women developed urothelial carcinoma. In a model including number of full-term pregnancies (FTP), menopausal status, and menopausal hormone therapy (MHT), number of FTP was inversely associated with urothelial carcinoma risk (HR≥5vs1 ¼ 0.48; 0.25–0.90; Ptrend in parous women ¼ 0.010) and MHT use (compared with nonuse) was positively associated with urothelial carcinoma risk (HR ¼ 1.27; 1.03–1.57), but no dose response by years of MHT use was observed. No modification of HRs by smoking status was observed. Finally, sensitivity analyses in never smokers showed similar HR patterns for the number of FTP, while no association between MHT use and urothelial carcinoma risk was observed. Association between MHT use and urothelial carcinoma risk remained significant only in current smokers. No heterogeneity of the risk estimations in the final model was observed by tumor aggressiveness or by tumor grade. A positive association between MTH use and non–muscle-invasive urothelial carcinoma risk was observed. Conclusions: Our results support that increasing the number of FTP may reduce urothelial carcinoma risk. Impact: More detailed studies on parity are needed to understand the possible effects of perinatal hormone changes in urothelial cells. © 2020 American Association for Cancer Research.
Published: 2020

14. Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition

Author: IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Obón-Santacana, M., Luján-Barroso, L., Freisling, H., Naudin, S., Boutron-Ruault, M.-C., Mancini, F.R., Rebours, V., Kühn, T., Katzke, V., Boeing, H., Tjønneland, A., Olsen, A., Overvad, K., Lasheras, C., Rodríguez-Barranco, M., Amiano, P., Santiuste, C., Ardanaz, E., Khaw, K.-T., Wareham, N.J., Aune, D., Trichopoulou, A., Thriskos, P., Peppa, E., Masala, G., Grioni, S., Tumino, R., Panico, S., Bueno-de-Mesquita, B., Sciannameo, V., Vermeulen, R., Sonestedt, E., Sund, M., Weiderpass, E., Skeie, G., Riboli, E., Duell, E.J., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Obón-Santacana, M., Luján-Barroso, L., Freisling, H., Naudin, S., Boutron-Ruault, M.-C., Mancini, F.R., Rebours, V., Kühn, T., Katzke, V., Boeing, H., Tjønneland, A., Olsen, A., Overvad, K., Lasheras, C., Rodríguez-Barranco, M., Amiano, P., Santiuste, C., Ardanaz, E., Khaw, K.-T., Wareham, N.J., Aune, D., Trichopoulou, A., Thriskos, P., Peppa, E., Masala, G., Grioni, S., Tumino, R., Panico, S., Bueno-de-Mesquita, B., Sciannameo, V., Vermeulen, R., Sonestedt, E., Sund, M., Weiderpass, E., Skeie, G., Riboli, E., and Duell, E.J.
Published: 2020

15. Consumption of fish is not associated with risk of differentiated thyroid carcinoma in the European prospective investigation into cancer and nutrition (EPIC) study

Author: Zamora-Ros, R. Castañeda, J. Rinaldi, S. Cayssials, V. Slimani, N. Weiderpass, E. Tsilidis, K.K. Boutron-Ruault, M.-C. Overvad, K. Eriksen, A.K. Tjønneland, A. Kühn, T. Katzke, V. Boeing, H. Trichopoulou, A. La Vecchia, C. Kotanidou, A. Palli, D. Grioni, S. Mattiello, A. Tumino, R. Sciannameo, V. Lund, E. Merino, S. Salamanca-Fernández, E. Amiano, P. Huerta, J.M. Barricarte, A. Ericson, U. Almquist, M. Hennings, J. Sandström, M. Bueno-de-Mesquita, H.B. Peeters, P.H. Khaw, K.-T. Wareham, N.J. Schmidt, J.A. Cross, A.J. Riboli, E. Scalbert, A. Romieu, I. Agudo, A. Franceschi, S.
Abstract: Background: Differentiated thyroid cancer (TC) is the most common endocrine cancer. Fish can be an important source of iodine and other micronutrients and contaminants that may affect the thyroid gland and TC risk. Objective: We prospectively evaluated the relations between the consumption of total fish and different fish types and shellfish and TC risk in the EPIC (European Prospective Investigation into Cancer and Nutrition) study. Methods: EPIC is a cohort of > 500,000 men and women, mostly aged 35-70 y, who were recruited in 10 European countries. After a mean follow-up of 14 y, 748 primary differentiated TC cases were diagnosed; 666 were in women and 601 were papillary TC. Data on intakes of lean fish, fatty fish, fish products, and shellfish were collected by using countryspecific validated dietary questionnaires at recruitment. Multivariable Cox regression was used to calculate HRs and 95% CIs adjusted for many potential confounders, including dietary and nondietary factors. Results: No significant association was observed between total fish consumption and differentiated TC risk for the highest compared with the lowest quartile (HR: 1.03; 95% CI: 0.81, 1.32; P-trend = 0.67). Likewise, no significant association was observed with the intake of any specific type of fish, fish product, or shellfish. No significant heterogeneity was found by TC subtype (papillary or follicular tumors), by sex, or between countries with low and high TC incidence. Conclusion: This large study shows that the intake of fish and shellfish was not associated with differentiated TC risk in Europe, a region in which iodine deficiency or excess is rare. © 2017 American Society for Nutrition.
Published: 2017

16. Randomized, placebo-controlled, double-blind trial of clobetasol propionate 0.05% in the treatment of oral lichen planus

Author: Arduino, PG, primary, Campolongo, MG, additional, Sciannameo, V, additional, Conrotto, D, additional, Gambino, A, additional, Cabras, M, additional, Ricceri, F, additional, Carossa, S, additional, Broccoletti, R, additional, and Carbone, M, additional
Published: 2018
Full Text: View/download PDF

17. L’associazione tra tumore della vescica e esposizioni professionali: analisi pooled di due studi caso-controllo italiani

Author: Sciannameo, V, Carta, Angela, D’Errico, A, Giraudo, Mt, Fasanelli, F, Arici, Cecilia, Maule, M, Destefanis, P, Rolle, L, Gontero, P, Casetta, G, Zitella, A, Cucchiarale, G, Vineis, P, Porru, Stefano, Sacerdote, C, and Ricceri, F.
Published: 2016

18. A practical clinical recording system for cases of desquamative gingivitis

Author: Arduino, P.G., primary, Broccoletti, R., additional, Sciannameo, V., additional, and Scully, C., additional
Published: 2017
Full Text: View/download PDF

19. 'THE TRATMENT OF HEPATOCELLULAR CARCINOMA:THE ROLE OF SURGERY IN A MULTIDISCIPLINARY APPROACH'

Author: Boselli, C., Gullà, M., Covarelli, P., D'Ajello, F., Cirocchi, R., Trastulli, S., Desiderio, J., Sciannameo, V., Santoro, Alberto, DI ROCCO, Giorgio, Avenia, N., Sciannameo, F., and Noya, G.
Published: 2011

20. THE TREATMENT OF HEPATOCELLULAR CARCINOMA: THE ROLE OF SURGERY IN A MULTIDISCIPLINARY APPROACH

Author: Boselli, Carlo, Gullà, M., Covarelli, Piero, D’Ajello, F., Cirocchi, Roberto, Trastulli, Stefano, Desiderio, J., Sciannameo, V., Di Rocco, G., Santoro, A., Avenia, Nicola, Sciannameo, Francesco, and Noya, Giuseppe
Published: 2011

21. Bisphosphonate-Related Osteonecrosis of the Jaw: A Retrospective Study on the Role of Dental Prophylaxis

Author: Sciannameo, V., primary, Matteini, C., additional, Perugini, M., additional, Di Curzio, P., additional, Saponaro, G., additional, and Taglia, C., additional
Published: 2013
Full Text: View/download PDF

22. Metabolic syndrome incidence in cases of oral lichen planus: a prospective case-control study in a Northern Italian population.

Author: Karimi, D., Broccoletti, R., Sciannameo, V., Ricceri, F., and Arduino, P. G.
Published: 2017

23. Treatments and outcomes: a retrospective analysis of patients affected from MORNJ among 2009 and 2016 at Turin University.

Author: Erovigni, F., Gambino, A., Dell'acqua, A., Sciannameo, V., and Carossa, S.
Published: 2017

24. The Impact of the COVID-19 Pandemic on Nursing Care: A Cross-Sectional Survey-Based Study

Author: Sara Campagna, Michela Luciani, Veronica Sciannameo, Alessio Conti, Marco Clari, Valerio Dimonte, Paola Berchialla, Paola Di Giulio, Clari, M, Luciani, M, Conti, A, Sciannameo, V, Berchialla, P, Di Giulio, P, Campagna, S, and Dimonte, V
Subjects: personalized care, medicine.medical_specialty, Nursing techniques, Coronavirus disease 2019 (COVID-19), patient care planning, business.industry, Symptom management, Cross-sectional study, MED/45 - SCIENZE INFERMIERISTICHE GENERALI, CLINICHE E PEDIATRICHE, Medicine (miscellaneous), COVID-19, Conditional inference tree, Article, Nursing care, quality of health care, conditional inference trees, Family medicine, Pandemic, medicine, Medicine, Level of care, business, nursing care, Patient education
Abstract: The COVID-19 pandemic has had a severe impact on nursing care. This cross-sectional survey-based study compared aspects of nursing care and nurses’ satisfaction with care provided before and during the first wave of the COVID-19 pandemic. A total of 936 registered nurses (RNs) rated the frequency with which they performed fundamental care, nursing techniques, patient education, symptom management, and nurse–patient relationships before and during the pandemic. A recursive partitioning for ordered multivariate response in a conditional inference framework approach was applied. More frequent fundamental cares were associated with their frequency before the pandemic (p &lt, 0.001), caring for COVID-19 patients (p &lt, 0.001), and workplace reassignment (p = 0.004). Caring for COVID-19 patients (p &lt, 0.001), workplace reassignment (p = 0.030), and caring for ≤7.4 COVID-19 patients (p = 0.014) increased nursing techniques. RNs in high-intensity COVID-19 units (p = 0.002) who educated patients before the pandemic, stopped this task. RNs caring for COVID-19 patients reported increased symptom management (p &lt, 0.001), as did RNs caring for more non-COVID-19 patients (p = 0.037). Less frequent nurse–patient relationships before the pandemic and working in high-intensity COVID-19 units decreased nurse–patient relationships (p = 0.002). Despite enormous challenges, nurses continued to provide a high level of care. Ensuring the appropriate deployment and education of nurses is crucial to personalize care and to maintain nurses’ satisfaction with the care provided.
Published: 2021
Full Text: View/download PDF

25. Machine learning in clinical and epidemiological research: Isn't it time for biostatisticians to work on it?

Author: Marika Vezzoli, Veronica Sciannameo, Dario Gregori, Fabiola Giudici, Valeria Edefonti, Andrea Faragalli, Francesca Ieva, Giulia Barbati, Ilaria Gandin, Giovanni Fiorito, Andrea Ricotti, Danila Azzolina, Alberto Milanese, Pasquale Dolce, Michele Marchioni, Daniele Bottigliengo, Corrado Lanera, Ileana Baldi, Andrea Bucci, Giuliana Solinas, Paola Berchialla, Stefano Calza, Caterina Gregorio, Giulia Lorenzoni, Azzolina, D., Baldi, I., Barbati, G., Berchialla, P., Bottigliengo, D., Bucci, A., Calza, S., Dolce, P., Edefonti, V., Faragalli, A., Fiorito, G., Gandin, I., Giudici, F., Gregori, D., Gregorio, C., Ieva, F., Lanera, C., Lorenzoni, G., Marchioni, M., Milanese, A., Ricotti, A., Sciannameo, V., Solinas, G., and Vezzoli, M.
Subjects: medicine.medical_specialty, education, Socio-culturale, Machine learning, computer.software_genre, Machine Learning, Economica, machine learning, statistics, epidemiology, Epidemiology, medicine, lcsh:R5-920, biomedical research, ComputingMilieux_THECOMPUTINGPROFESSION, business.industry, lcsh:Public aspects of medicine, Ambientale, lcsh:RA1-1270, Medical statistics, Work (electrical), statistics, epidemiology, Artificial intelligence, lcsh:Medicine (General), business, Psychology, computer
Abstract: In recent years, there has been a widespread cross-fertilization between Medical Statistics and Machine Learning (ML) techniques.
Published: 2019

26. Information extraction from medical case reports using OpenAI InstructGPT.

Author: Sciannameo V, Pagliari DJ, Urru S, Grimaldi P, Ocagli H, Ahsani-Nasab S, Comoretto RI, Gregori D, and Berchialla P
Subjects: Humans, Information Storage and Retrieval methods, Child, Algorithms, Male, Data Mining methods, Female, Natural Language Processing
Abstract: Background and Objective: Researchers commonly use automated solutions such as Natural Language Processing (NLP) systems to extract clinical information from large volumes of unstructured data. However, clinical text's poor semantic structure and domain-specific vocabulary can make it challenging to develop a one-size-fits-all solution. Large Language Models (LLMs), such as OpenAI's Generative Pre-Trained Transformer 3 (GPT-3), offer a promising solution for capturing and standardizing unstructured clinical information. This study evaluated the performance of InstructGPT, a family of models derived from LLM GPT-3, to extract relevant patient information from medical case reports and discussed the advantages and disadvantages of LLMs versus dedicated NLP methods., Methods: In this paper, 208 articles related to case reports of foreign body injuries in children were identified by searching PubMed, Scopus, and Web of Science. A reviewer manually extracted information on sex, age, the object that caused the injury, and the injured body part for each patient to build a gold standard to compare the performance of InstructGPT., Results: InstructGPT achieved high accuracy in classifying the sex, age, object and body part involved in the injury, with 94%, 82%, 94% and 89%, respectively. When excluding articles for which InstructGPT could not retrieve any information, the accuracy for determining the child's sex and age improved to 97%, and the accuracy for identifying the injured body part improved to 93%. InstructGPT was also able to extract information from non-English language articles., Conclusions: The study highlights that LLMs have the potential to eliminate the necessity for task-specific training (zero-shot extraction), allowing the retrieval of clinical information from unstructured natural language text, particularly from published scientific literature like case reports, by directly utilizing the PDF file of the article without any pre-processing and without requiring any technical expertise in NLP or Machine Learning. The diverse nature of the corpus, which includes articles written in languages other than English, some of which contain a wide range of clinical details while others lack information, adds to the strength of the study., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)
Published: 2024
Full Text: View/download PDF

27. Internal Consistency and Floor/Ceiling Effects of the Gross Motor Function Measure for Use with Children Affected by Cancer: A Cross-Sectional Study.

Author: Rossi F, Valle M, Galeoto G, Tofani M, Berchialla P, Sciannameo V, Bertin D, Calcagno A, Casalaz R, Cerboneschi M, Cervo M, Cornelli A, Di Pede C, Esposito M, Ferrarese M, Imazio P, Lorenzon M, Longo L, Martinuzzi A, Naretto G, Orsini N, Panzeri D, Pellegrini C, Peranzoni M, Picone F, Rabusin M, Ricci F, Zigrino C, Zucchetti G, and Fagioli F
Subjects: Humans, Cross-Sectional Studies, Child, Male, Female, Adolescent, Child, Preschool, Motor Skills physiology, Reproducibility of Results, Neoplasms physiopathology
Abstract: Children/adolescents with cancer can develop adverse effects impacting gross motor function. There is a lack of gross motor function assessment tools that have been validated for this population. The aim of this multicenter cross-sectional study was to preliminary validate the 88-item Gross Motor Function Measure (GMFM-88) for use in children/adolescents with cancer, exploring internal consistency and floor/ceiling effect. Inclusion criteria regarded children/adolescents diagnosed with cancer on treatment or <1 year off therapy. The internal consistency was assessed using Cronbach's α, and the floor-ceiling effects were calculated through percentage. This study involved 217 participants with heterogeneous neoplasm conditions. Internal consistency was good, with a Cronbach's α of 0.989. Floor-ceiling effect analysis reveals that several items obtained a dichotomous scoring distribution in each of the five sub-scales of the GMFM-88. This can be explained by the heterogeneous clinical characteristics of the target population. The preliminary validation of GMFM-88 in a group of children/adolescents affected by cancer suggests that some items are not able to discriminate between different gross motor function levels, and therefore it does not represent an informative tool to measure gross motor function in children with cancer. Future research is needed to define which ones could be more useful for clinical practice.
Published: 2024
Full Text: View/download PDF

28. Combining an Anterolateral Complex Procedure With Anterior Cruciate Ligament Reconstruction Reduces the Graft Reinjury Rate and Improves Clinical Outcomes: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Author: Bosco F, Giustra F, Masoni V, Capella M, Sciannameo V, Camarda L, Massè A, and LaPrade RF
Subjects: Humans, Patient Reported Outcome Measures, Randomized Controlled Trials as Topic, Reinjuries surgery, Tenodesis methods, Anterior Cruciate Ligament Injuries surgery, Anterior Cruciate Ligament Reconstruction methods
Abstract: Background: Anterior cruciate ligament (ACL) reconstruction (ACLR) is a well-established surgical procedure, but it may not always restore complete rotational knee stability. Interest is increasing in anterolateral complex (ALC) procedures, lateral extra-articular tenodesis (LET) and anterolateral ligament reconstruction (ALLR), in association with ACLR to overcome this problem. The better ALC procedure, LET or ALLR, remains controversial to date., Purpose: To analyze the patient-reported outcome measures and ACL reinjury rate after ACLR with an ALC procedure compared with after isolated ACLR, as well as to analyze the clinical results and graft failure rate of the LET group versus the ALLR group., Study Design: Systematic review and meta-analysis; Level of evidence, 2., Methods: A PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flowchart was used to conduct a comprehensive search of 5 databases: Scopus, MEDLINE, Embase, PubMed, and the Cochrane Database of Systematic Reviews. Only randomized controlled trials were included. Eligible articles were classified according to the levels of evidence of the Oxford Centre for Evidence-Based Medicine. A methodological quality assessment of randomized controlled trials was performed using the Risk of Bias 2 tool. The present systematic review and meta-analysis was registered on PROSPERO., Results: A total of 14 clinical trials were included in the final analysis, with 1830 patients. Isolated ACLR or a combined procedure with LET or ALLR was performed, with several characteristics described, including the surgical technique, additional torn knee structures and their management, graft failure, complications, clinical outcomes, clinical and instrumental examinations to assess knee stability, and postoperative protocols. Regarding clinical outcomes, pivot-shift tests and reduced graft failure, a significant difference was found in the superiority of the combined ACLR associated with the ALC procedure compared with an isolated ACLR ( P < .05). No statistically significant difference was found between the 2 ALC procedures., Conclusion: This systematic review and meta-analysis reported on the importance of combined ACLR and ALC procedures in patients with a high-grade rotational laxity, as both procedures, LET or ALLR, without superiority of one over the other, are associated with improved pivot-shift tests, patient-reported outcome measures, and reduced graft failure rates., Competing Interests: One or more of the authors has declared the following potential conflict of interest or source of funding: R.F.L. has received consulting fees from Smith + Nephew; support for education from Foundation Medical, and royalties from Arthrex and Smith + Nephew. AOSSM checks author disclosures against the Open Payments Database (OPD). AOSSM has not conducted an independent investigation on the OPD and disclaims any liability or responsibility relating thereto.
Published: 2024
Full Text: View/download PDF

29. Prolonged 14-day continuous infusion of high-dose ifosfamide for patients with relapsed and refractory high-grade osteosarcoma: a retrospective multicentre cohort study.

Author: Tirtei E, Campello A, Sciannameo V, Asaftei SD, Meazza C, Sironi G, Longhi A, Ibrahim T, Tamburini A, Coccoli L, Crocco F, Cagnazzo C, De Luna E, Quarello P, Berchialla P, and Fagioli F
Subjects: Humans, Male, Female, Retrospective Studies, Adult, Adolescent, Young Adult, Middle Aged, Child, Antineoplastic Agents, Alkylating administration & dosage, Antineoplastic Agents, Alkylating therapeutic use, Antineoplastic Agents, Alkylating adverse effects, Neoplasm Grading, Treatment Outcome, Ifosfamide administration & dosage, Ifosfamide adverse effects, Ifosfamide therapeutic use, Osteosarcoma drug therapy, Osteosarcoma mortality, Osteosarcoma pathology, Bone Neoplasms drug therapy, Bone Neoplasms mortality, Bone Neoplasms pathology, Neoplasm Recurrence, Local drug therapy
Abstract: Background: The prognosis of patients with Relapsed/Refractory Osteosarcoma (R/R OS) remains dismal without an agreement on systemic therapy. The use of High-Dose Ifosfamide (14 g/sqm) with an external pump in outpatient setting (14-IFO) in R/R OS patients is limited. This study represents the first retrospective cohort analysis focused on evaluating the activity and toxicity of 14-IFO in this setting., Patients and Methods: The study investigated 14-IFO activity, in terms of tumour response according to RECIST 1.1 criteria, as well as survival rates and toxicity, according to CTCAE v.5., Results: The trial enrolled 26 patients with R/R OS. The Overall Response Rate (ORR) and Disease Control Rate (DCR) obtained was 23% and 57.5%, respectively. Patients with relapsed OS showed a higher ORR (45%) and DCR (82%) compared to refractory patients, irrespective of the number of prior treatment lines received. The achievement of disease control with 14-IFO administration enabled 27% of patients to undergo new local treatment. Four-month Progression-Free Survival (PFS) was 54% for all patients and 82% for the relapsed OS sub-group. Median Overall Survival (OSurv) was 13.7 months, with 1-year OSurv of 51% for all patients and 71% for relapsed patients. Age over 18 years and the presence of refractory disease were identified as negative prognostic factors for this patient cohort. A total of 101 cycles were evaluated for toxic assessment, demonstrating a tolerable profile without grade 3-4 non-haematological toxicities., Conclusions: 14-IFO should be considered a viable treatment option for R/R OS, particularly due to its well tolerated toxicity profile and the potential for home-administration, which can improve patient quality of life without compromising efficacy., (© 2024. The Author(s).)
Published: 2024
Full Text: View/download PDF

30. Surgical treatment of popliteomeniscal fascicles tears is associated with better patient-reported outcome measures. A systematic review and meta-analysis.

Author: Masoni V, Giustra F, Bosco F, Camarda L, Rovere G, Sciannameo V, Berchialla P, and Massè A
Subjects: Humans, Lysholm Knee Score, Arthroscopy methods, Ligaments, Articular, Treatment Outcome, Knee Joint surgery, Sports
Abstract: Purpose: Popliteomeniscal fascicles (PMFs) are a component of the popliteal hiatus complex in the knee, and their injury primarily affects young athletes participating in sports activities involving twisting movements. The identification of PMFs tears presents a challenge, often accompanied by lateral pain and a locking sensation. The objective of this systematic review (SR) and meta-analysis is to enhance the suspicion and recognition of PMFs tears, aiming to facilitate the treatment of this condition, particularly in symptomatic young patients., Methods: A comprehensive search, focused on studies examining PMFs injuries and their treatment, was conducted in four databases, PubMed, Scopus, Embase, and Web of Science. The ROBINS-I tool was used to evaluate the risks of bias. The PRISMA flow diagram was used to conduct the research and select the included studies. A meta-analysis was conducted for the Lysholm score, the Tegner Activity Scale, and the subjective IKDC score. The present SR and meta-analysis was registered on PROSPERO., Results: Five clinical studies were included in the final analysis, comprising 96 patients. All the patients underwent a preoperative MRI assessment and a diagnostic arthroscopy to detect the PMFs tears, with a subsequent surgical procedure either open or arthroscopically performed. Surgery was associated with the resolution of symptoms. A statistically significant improvement in the Lysholm score (p: 0.0005) and the subjective IKDC score (p: 0.003) after the surgical procedure with respect to the preoperative evaluation was found., Conclusion: This SR and meta-analysis showed a significant improvement in the Lysholm score and subjective IKDC score following surgery for PMFs tears. However, controversy persists regarding the optimal surgical approach, with current literature favoring arthroscopic procedures., Level of Evidence: IV., (© 2023. The Author(s).)
Published: 2024
Full Text: View/download PDF

31. Fitting Early Phases of the COVID-19 Outbreak: A Comparison of the Performances of Used Models.

Author: Sciannameo V, Azzolina D, Lanera C, Acar AŞ, Corciulo MA, Comoretto RI, Berchialla P, and Gregori D
Abstract: The COVID-19 outbreak involved a spread of prediction efforts, especially in the early pandemic phase. A better understanding of the epidemiological implications of the different models seems crucial for tailoring prevention policies. This study aims to explore the concordance and discrepancies in outbreak prediction produced by models implemented and used in the first wave of the epidemic. To evaluate the performance of the model, an analysis was carried out on Italian pandemic data from February 24, 2020. The epidemic models were fitted to data collected at 20, 30, 40, 50, 60, 70, 80, 90, and 98 days (the entire time series). At each time step, we made predictions until May 31, 2020. The Mean Absolute Error ( MAE ) and the Mean Absolute Percentage Error ( MAPE ) were calculated. The GAM model is the most suitable parameterization for predicting the number of new cases; exponential or Poisson models help predict the cumulative number of cases. When the goal is to predict the epidemic peak, GAM, ARIMA, or Bayesian models are preferable. However, the prediction of the pandemic peak could be made carefully during the early stages of the epidemic because the forecast is affected by high uncertainty and may very likely produce the wrong results.
Published: 2023
Full Text: View/download PDF

32. Impact of Hypothermic Oxygenated Machine Perfusion on Hepatocellular Carcinoma Recurrence after Liver Transplantation.

Author: Rigo F, De Stefano N, Patrono D, De Donato V, Campi L, Turturica D, Doria T, Sciannameo V, Berchialla P, Tandoi F, and Romagnoli R
Abstract: Background: Machine perfusion may be able to mitigate ischemia-reperfusion injury (IRI), which increases hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT). This study aimed to investigate the impact of dual-hypothermic oxygenated machine perfusion (D-HOPE) on HCC recurrence in LT., Methods: A single-center retrospective study was conducted from 2016 to 2020. Pre- and postoperative data of HCC patients undergoing LT were analyzed. Recipients of a D-HOPE-treated graft were compared to those of livers preserved using static cold storage (SCS). The primary endpoint was recurrence-free survival (RFS)., Results: Of 326 patients, 246 received an SCS-preserved liver and 80 received a D-HOPE-treated graft (donation after brain death (DBD), n = 66; donation after circulatory death (DCD), n = 14). Donors of D-HOPE-treated grafts were older and had higher BMI. All DCD donors were treated by normothermic regional perfusion and D-HOPE. The groups were comparable in terms of HCC features and estimated 5-year RFS according to the Metroticket 2.0 model. D-HOPE did not reduce HCC recurrence (D-HOPE 10%; SCS 8.9%; p = 0.95), which was confirmed using Bayesian model averaging and inverse probability of treatment weighting-adjusted RFS analysis. Postoperative outcomes were comparable between groups, except for lower AST and ALT peak in the D-HOPE group., Conclusions: In this single-center study, D-HOPE did not reduce HCC recurrence but allowed utilizing livers from extended criteria donors with comparable outcomes, improving access to LT for patients suffering from HCC.
Published: 2023
Full Text: View/download PDF

33. Highly cross-linked polyethylene versus conventional polyethylene in primary total knee arthroplasty: comparable clinical and radiological results at a 10-year follow-up.

Author: Giustra F, Bistolfi A, Bosco F, Fresia N, Sabatini L, Berchialla P, Sciannameo V, and Massè A
Subjects: Humans, Polyethylene, Follow-Up Studies, Retrospective Studies, Prosthesis Design, Prosthesis Failure, Arthroplasty, Replacement, Knee methods, Arthroplasty, Replacement, Hip, Hip Prosthesis
Abstract: Purpose: Highly crosslinked polyethylene (HXLPE) was introduced in total knee arthroplasty (TKA) to reduce wear and consequent revisions for loosening due to conventional polyethylene (CPE) wear. This study aims to analyse whether HXLPE is as safe as CPE and could improve the TKA clinical and radiological results in a long-term follow-up., Methods: This retrospective study included all consecutive starting series of 223 patients with severe primary knee osteoarthritis (OA), with a minimum follow-up of 10 years treated between July 1st, 2007, and July 31st, 2010. After excluding patients who did not respect the inclusion and exclusion criteria, 128 patients were included in the analysis of this study. The patients were then divided into two groups according to the type of polyethylene (PE) implanted: CPE or HXLPE liners. All patients were evaluated for clinical and radiological parameters, causes and revision rates related to the type of PE implanted., Results: HXLPE appears to be as safe as CPE in TKA, reporting no higher revisions for osteolysis, prosthesis loosening, infection, and mechanical failure. Nevertheless, no statistically significant differences were found between the two groups in the clinical and radiological outcomes evaluated., Conclusions: Clinical, radiological results, and revision rates are similar between HXLPE and CPE in TKA after 10 years of follow-up, although HXLPE benefits remain controversial., Level of Evidence: III., (© 2022. The Author(s).)
Published: 2023
Full Text: View/download PDF

34. Effectiveness of Workplace Health Promotion (WHP) interventions in university employees: a scoping review.

Author: Moroni A, Degan R, Martin B, Sciannameo V, Berchialla P, Gilli G, and Micheletti Cremasco M
Subjects: Humans, Universities, Workplace, Exercise, Life Style, Health Promotion methods, Occupational Health
Abstract: Workplace Health Promotion (WHP) interventions proved to be effective in several workplace contexts. Currently, the effectiveness of such interventions in the academic workplace is lacking, albeit evidence suggests similar patterns to those occurring in other workplace sectors. The aim of this study was to review WHP interventions in the university workplace that led to improve health- and work-related outcomes. Articles were selected using Pubmed, Web of Science, Scopus, Embase, PsycInfo, Cinhal and FSTA, using search strings focused on health- and/or work-related outcomes and involving University WHP interventions published between January 2010 and July 2021. The majority of the 12 studies selected reported positive results in their individuality, especially regarding health-related outcomes [biological such as weight loss, physical activity, mental health and lifestyle habits] and work-related outcomes concerning improvements either for the employee or for the working system. Studies on economic advantage and Return on Investment were limited and reported contrasting results. In conclusion, we have highlighted how the studies on effectiveness of WHP interventions in the university context are few and heterogeneous and need to be encouraged further research in order to build specific guidelines that are effective., (© The Author(s) 2023. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Published: 2023
Full Text: View/download PDF

35. Enhanced Recovery after Surgery (ERAS) Program for Patients with Peritoneal Surface Malignancies Undergoing Cytoreductive Surgery with or without HIPEC: A Systematic Review and a Meta-Analysis.

Author: Robella M, Tonello M, Berchialla P, Sciannameo V, Ilari Civit AM, Sommariva A, Sassaroli C, Di Giorgio A, Gelmini R, Ghirardi V, Roviello F, Carboni F, Lippolis PV, Kusamura S, and Vaira M
Abstract: Enhanced recovery after surgery (ERAS) program refers to a multimodal intervention to reduce the length of stay and postoperative complications; it has been effective in different kinds of major surgery including colorectal, gynaecologic and gastric cancer surgery. Its impact in terms of safety and efficacy in the treatment of peritoneal surface malignancies is still unclear. A systematic review and a meta-analysis were conducted to evaluate the effect of ERAS after cytoreductive surgery with or without HIPEC for peritoneal metastases. MEDLINE, PubMed, EMBASE, Google Scholar and Cochrane Database were searched from January 2010 and December 2021. Single and double-cohort studies about ERAS application in the treatment of peritoneal cancer were considered. Outcomes included the postoperative length of stay (LOS), postoperative morbidity and mortality rates and the early readmission rate. Twenty-four studies involving 5131 patients were considered, 7 about ERAS in cytoreductive surgery (CRS) + HIPEC and 17 about cytoreductive alone; the case histories of two Italian referral centers in the management of peritoneal cancer were included. ERAS adoption reduced the LOS (-3.17, 95% CrI -4.68 to -1.69 in CRS + HIPEC and -1.65, 95% CrI -2.32 to -1.06 in CRS alone in the meta-analysis including 6 and 17 studies respectively. Non negligible lower postoperative morbidity was also in the meta-analysis including the case histories of two Italian referral centers. Implementation of an ERAS protocol may reduce LOS, postoperative complications after CRS with or without HIPEC compared to conventional recovery.
Published: 2023
Full Text: View/download PDF

36. Assessment of Glucose Lowering Medications' Effectiveness for Cardiovascular Clinical Risk Management of Real-World Patients with Type 2 Diabetes: Targeted Maximum Likelihood Estimation under Model Misspecification and Missing Outcomes.

Author: Sciannameo V, Fadini GP, Bottigliengo D, Avogaro A, Baldi I, Gregori D, and Berchialla P
Subjects: Humans, Likelihood Functions, Glucose, Retrospective Studies, Risk Management, Diabetes Mellitus, Type 2 drug therapy
Abstract: The results from many cardiovascular (CV) outcome trials suggest that glucose lowering medications (GLMs) are effective for the CV clinical risk management of type 2 diabetes (T2D) patients. The aim of this study is to compare the effectiveness of two GLMs (SGLT2i and GLP-1RA) for the CV clinical risk management of T2D patients in a real-world setting, by simultaneously reducing glycated hemoglobin, body weight, and systolic blood pressure. Data from the real-world Italian multicenter retrospective study Dapagliflozin Real World evideNce in Type 2 Diabetes (DARWINT 2D) are analyzed. Different statistical approaches are compared to deal with the real-world-associated issues, which can arise from model misspecification, nonrandomized treatment assignment, and a high percentage of missingness in the outcome, and can potentially bias the marginal treatment effect (MTE) estimate and thus have an influence on the clinical risk management of patients. We compare the logistic regression (LR), propensity score (PS)-based methods, and the targeted maximum likelihood estimator (TMLE), which allows for the use of machine learning (ML) models. Furthermore, a simulation study is performed, resembling the structure of the conditional dependencies among the main variables in DARWIN-T2D. LR and PS methods do not underline any difference in the effectiveness regarding the attainment of combined CV risk factor goals between the two treatments. TMLE suggests instead that dapagliflozin is significantly more effective than GLP-1RA for the CV risk management of T2D patients. The results from the simulation study suggest that TMLE has the lowest bias and SE for the estimate of the MTE.
Published: 2022
Full Text: View/download PDF

37. Rehabilitation in children and adolescents undergoing stem cell transplantation: A pilot study focused on motor performance.

Author: Rossi F, Zucchetti G, Esposito M, Berchialla P, Sciannameo V, Vassallo E, Saglio F, Chamorro Viña C, Scarrone S, Vittorini R, and Fagioli F
Subjects: Child, Adolescent, Humans, Child, Preschool, Pilot Projects, Muscle Strength physiology, Fatigue etiology, Stem Cell Transplantation, Hematopoietic Stem Cell Transplantation adverse effects
Abstract: Objectives: The aim of this pilot trial is evaluating the preliminary effectiveness of two in-hospital interventions in the maintenance of motor performance in children/adolescents undergoing hematopoietic stem cell transplantation (HSCT). Secondary objectives investigated the interventions' feasibility, impact on fatigue and to what degree the subjects' maintained their ankle dorsiflexion range of movement (ROM), functional mobility, muscle strength and flexibility., Methods: This trial included 5- to 18-year-old participants, affected by oncological and non-oncological diseases during hospitalisation for autologous/allogenic HSCT. The subjects were assigned to an exercise group (EG), or a counselling group based on a cluster model based on inpatient timeframe. The EG subjects performed strengthening, stretching and aerobic exercises for 30 min/5 days a week. Both groups followed rehabilitation counselling indications (RCI), 7 days a week., Results: Forty-nine participants were enrolled (median age = 12.9 years) (EG n = 36). In both groups the participants maintained their baseline motor performance and ankle ROM, and the children/adolescents and parents reduced their levels of fatigue. However, the interventions were not effective in maintaining strength., Conclusion: In maintaining the subjects' motor performance, the RCI results are significant because they pave the way for the application in clinical practice contexts where there are poor rehabilitation resources. Clinical Trials registration NCT03842735., (© 2022 John Wiley & Sons Ltd.)
Published: 2022
Full Text: View/download PDF

38. A topic trend analysis on COVID-19 literature.

Author: Urru S, Sciannameo V, Lanera C, Salaris S, Gregori D, and Berchialla P
Abstract: Objective: In the past 2 years, the number of scientific publications has grown exponentially. The COVID-19 outbreak hugely contributed to this dramatic increase in the volume of published research. Currently, text mining of the volume of SARS-CoV-2 and COVID-19 publications is limited to the first months of the outbreak. We aim to identify the major topics in COVID-19 literature collected from several citational sources and analyze the temporal trend from November 2019 to December 2021., Methods: We performed an extensive literature search on SARS-Cov-2 and COVID-19 publications on PubMed, Scopus, and Web of Science (WoS) and a structural topic modelling on the retrieved abstracts. The temporal trend of the recognized topics was analyzed. Furthermore, a comparison between our corpus and the COVID-19 Open Research Dataset (CORD-19) repository was performed., Results: We collected 269,186 publications and identified 10 topics. The most popular topic was related to the clinical pictures of the COVID-19 outbreak, which has a constant trend, and the least popular includes studies on COVID-19 literature and databases. "Telemedicine", "Vaccine development", and "Epidemiology" were popular topics in the early phase of the pandemic; increasing topics in the last period are "COVID-19 impact on mental health", "Forecasting", and "Molecular Biology". "Education" was the second most popular topic, which emerged in September 2020., Conclusions: We identified 10 topics for classifying COVID-19 research publications and estimated a nonlinear temporal trend that gives an overview of their unfolding over time. Several citational databases must be searched to retrieve a complete set of studies despite the efforts to build repositories for COVID-19 literature. Our collected data can help build a more focused literature search between November 2019 and December 2021 when carrying out systematic and rapid reviews and our findings can give a complete picture on the topic., Competing Interests: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article., (© The Author(s) 2022.)
Published: 2022
Full Text: View/download PDF

39. Comparable results between crosslinked polyethylene and conventional ultra-high molecular weight polyethylene implanted in total knee arthroplasty: systematic review and meta-analysis of randomised clinical trials.

Author: Bistolfi A, Giustra F, Bosco F, Faccenda C, Viotto M, Sabatini L, Berchialla P, Sciannameo V, Graziano E, and Massè A
Subjects: Humans, Polyethylene, Polyethylenes, Prosthesis Design, Prosthesis Failure, Randomized Controlled Trials as Topic, Arthroplasty, Replacement, Knee, Knee Prosthesis, Osteolysis
Abstract: Purpose: Total knee arthroplasty (TKA) has experienced exponential growth over the last decade, including increasingly younger patients with high functional demands. Highly crosslinked polyethylene (HXLPE) has been proven effective in reducing osteolysis and loosening revisions while improving long-term survival and performance in total hip arthroplasty; nevertheless, this superiority is not demonstrated in TKA. The aim of this systematic review and meta-analysis was to examine whether HXLPE improved overall survival and postoperative functional and radiological outcomes compared to conventional polyethylene (CPE) in TKA., Methods: According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline, a literature search of five databases (PubMed, Medline, Scopus, Science Direct and Embase) was made. A PICOS model was performed. The initial screening identified 2541 studies. Each eligible clinical article was analysed according to the Oxford Centre for Evidence-Based Medicine 2011 Levels of Evidence (LoE). Only randomised clinical trials (RCTs) of LoE 1 and 2 were included. The methodological quality of the articles was assessed using the Risk of Bias 2 (RoB 2) tool., Results: Six clinical studies were included in the final study. This systematic review and meta-analysis were registered on the International Prospective Register of Systematic Reviews (PROSPERO). A total of 2285 knees were included. Eight outcomes (total reoperations, reoperations for prosthesis loosening and infections, radiolucent lines, osteolysis, mechanical failure, postoperative KSS knee score and function score) were analysed. For none of them, a statistically significant difference was found about the superiority of HXLPE over CPE (p > 0.05)., Conclusions: There were no statistically significant differences between HXLPE and CPE for TKA concerning clinical, radiological, and functional outcomes; nevertheless, HXLPE did not show higher failure rates or complications and can be safely used for TKA., Level of Evidence: II., (© 2022. The Author(s).)
Published: 2022
Full Text: View/download PDF

40. A deep learning approach for Spatio-Temporal forecasting of new cases and new hospital admissions of COVID-19 spread in Reggio Emilia, Northern Italy.

Author: Sciannameo V, Goffi A, Maffeis G, Gianfreda R, Jahier Pagliari D, Filippini T, Mancuso P, Giorgi-Rossi P, Alberto Dal Zovo L, Corbari A, Vinceti M, and Berchialla P
Subjects: Hospitals, Humans, Italy epidemiology, SARS-CoV-2, COVID-19 epidemiology, Deep Learning
Abstract: Background: Since February 2020, the COVID-19 epidemic has rapidly spread throughout Italy. Some studies showed an association of environmental factors, such as PM 10 , PM 2.5, NO 2 , temperature, relative humidity, wind speed, solar radiation and mobility with the spread of the epidemic. In this work, we aimed to predict via Deep Learning the real-time transmission of SARS-CoV-2 in the province of Reggio Emilia, Northern Italy, in a grid with a small resolution (12 km × 12 km), including satellite information., Methods: We focused on the Province of Reggio Emilia, which was severely hit by the first wave of the epidemic. The outcomes included new SARS-CoV-2 infections and COVID-19 hospital admissions. Pollution, meteorological and mobility data were analyzed. The spatial simulation domain included the Province of Reggio Emilia in a grid of 40 cells of (12 km) 2 . We implemented a ConvLSTM, which is a spatio-temporal deep learning approach, to perform a 7-day moving average to forecast the 7th day after. We used as training and validation set the new daily infections and hospital admissions from August 2020 to March 2021. Finally, we assessed the models in terms of Mean Absolute Error (MAE) compared with Mean Observed Value (MOV) and Root Mean Squared Error (RMSE) on data from April to September 2021. We tested the performance of different combinations of input variables to find the best forecast model., Findings: Daily new cases of infection, mobility and wind speed resulted in being strongly predictive of new COVID-19 hospital admissions (MAE = 2.72 in the Province of Reggio Emilia; MAE = 0.62 in Reggio Emilia city), whereas daily new cases, mobility, solar radiation and PM 2.5 turned out to be the best predictors to forecast new infections, with appropriate time lags., Interpretation: ConvLSTM achieved good performances in forecasting new SARS-CoV-2 infections and new COVID-19 hospital admissions. The spatio-temporal representation allows borrowing strength from data neighboring to forecast at the level of the square cell (12 km) 2 , getting accurate predictions also at the county level, which is paramount to help optimise the real-time allocation of health care resources during an epidemic emergency., (Copyright © 2022 Elsevier Inc. All rights reserved.)
Published: 2022
Full Text: View/download PDF

41. Factors Associated With Missed Nursing Care in Nursing Homes: A Multicentre Cross-sectional Study.

Author: Campagna S, Conti A, Clari M, Basso I, Sciannameo V, Di Giulio P, and Dimonte V
Subjects: Humans, Cross-Sectional Studies, Workload, Hospitals, Nursing Homes, Nursing Care
Abstract: Background: Despite its association with patient safety, few studies on missed nursing care have been conducted in nursing homes. We aimed to describe individual and environmental factors in a sample of registered nurses (RNs) reporting missed nursing care in nursing homes, and to explore the association between these factors and missed nursing care., Methods: In the present, multicentre cross-sectional study, 217 RNs from 43 nursing homes in Northern Italy reported all episodes of missed nursing care (ie, any aspect of required care that was omitted or delayed) that occurred in the 20 most dependent residents (according to RNs' judgement; 860 residents in total) over 3 consecutive days. Multilevel multivariable logistic regression models were used to test possible explanatory factors of missed nursing care (individual, work-related, organisational, and work environment factors), which were entered in a step-wise manner., Results: Younger RNs ( P =.026), freelance RNs ( P =.046), RNs with a permanent contract ( P =.035), and those working in publicly-owned nursing homes reported more episodes of missed nursing care ( P <.012). Public ownership (odds ratio [OR]=9.88; 95% CI 2.22-44.03; P =.003), a higher proportion of residents with severe clinical conditions (OR=2.45; 95% CI 1.12-5.37; P =.025), a lower proportion of RNs (OR=2.24; 95% CI 1.10-4.54; P =.026), and perceived lack of time to care for residents (OR=2.33; 95% CI 1.04-5.26; P =.041) were statistically significantly associated with missed nursing care., Conclusion: Factors associated with missed nursing care are similar in hospitals and nursing homes, and include heavy workload and perceived lack of time for care. Because missed nursing care in nursing homes represents tasks performed specifically by RNs, missed nursing care in this setting should be measured in terms of these tasks. An optimal skill mix is crucial to guarantee not only comfort and basic care for nursing home residents, but also good outcomes for residents with severe clinical conditions., (© 2022 The Author(s); Published by Kerman University of Medical Sciences This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.)
Published: 2022
Full Text: View/download PDF

42. Health status assessment of a population of asylum seekers in Northern Italy.

Author: Manfredi L, Sciannameo V, Destefanis C, Prisecaru M, Cossu G, Gnavi R, Macciotta A, Catalano A, Pepe RR, Sacerdote C, and Ricceri F
Subjects: Adolescent, Adult, Africa South of the Sahara epidemiology, Cross-Sectional Studies, Female, Health Status, Humans, Italy epidemiology, Male, Retrospective Studies, Young Adult, Refugees
Abstract: Background: Since 2011 Italy has faced an extraordinary increase in migrants arrivals, mainly from the Mediterranean route, one of the world's most dangerous journeys. The purpose of the present article is to provide a comprehensive picture of the migrants' health status in the "T. Fenoglio" centre, Settimo Torinese (Turin, Italy)., Methods: A retrospective cross-sectional study was conducted using data collected from June 2016 to May 2018 on adult migrants (over 18 years old) from Africa, Middle East and South East Asia (Bangladesh, Cambodia, India, Nepal). Data was collected through the migrants' medical records. Descriptive statistics were performed on socio-demographic variables. The diagnosed diseases were anonymously registered and classified according to the International Classification of Primary Care (ICPC-2). Conditional Inference Trees were used to perform a descriptive analysis of the sample and to detect the covariates with the strongest association with the variables Disease on arrival, Disease after arrival, ICPC on arrival and ICPC after arrival., Results: Analyzed observations were 9 857. 81.8% were men, median age was 23 (Interquartile range: 20.0-27.4). 70.3% of the sample came from Sub-Saharan Africa. 2 365 individuals (24%) arrived at the centre with at least one disease. On arrival, skin (27.71%), respiratory (14.46%), digestive (14.73%) and generic diseases (20.88%) were the most frequent. During the stay respiratory diseases were the most common (25.70%). The highest probability of arriving with a disease occurred in 2018 and during the period September-November 2016, in particular for people from the Horn of Africa. During this period and also in the first half of 2017, skin diseases were the most reported. In seasons with lower prevalence of diseases on arrival the most common disease code was generic for both men and women (usually fever or trauma)., Conclusions: This study provides information on the diverse diseases that affect the asylum seekers population. In our sample, the Horn of Africa was the most troubled area of arrival, with severe conditions frequently reported regarding skin diseases, in particular scabies. 2018 was the most critical year, especially for migrants from the Horn of Africa and Sub-Saharan Africa. During the stay at the camp, the prevalence of respiratory diseases increased. However, skin diseases remained the main issue for people from the Horn of Africa. Overall, the most reported diseases in the sample were dermatological, respiratory, digestive and generic diseases, both on arrival and during the stay. A better understanding of the health status of asylum seekers is an important factor to determine a more efficient reception and integration process and a better allocation of economic resources in the context of migrants' health care., (© 2022. The Author(s).)
Published: 2022
Full Text: View/download PDF

43. Colorectal cancer chemotherapy: can sex-specific disparities impact on drug toxicities?

Author: De Francia S, Berchialla P, Armando T, Storto S, Allegra S, Sciannameo V, Soave G, Sprio AE, Racca S, Caiaffa MR, Ciuffreda L, and Mussa MV
Subjects: Alopecia chemically induced, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Female, Fluorouracil therapeutic use, Heartburn chemically induced, Heartburn drug therapy, Humans, Leucovorin, Male, Nausea chemically induced, Nausea drug therapy, Nausea epidemiology, Retrospective Studies, Vomiting chemically induced, Anemia drug therapy, Colorectal Neoplasms drug therapy, Drug-Related Side Effects and Adverse Reactions epidemiology, Drug-Related Side Effects and Adverse Reactions etiology, Mucositis chemically induced, Mucositis epidemiology, Thrombocytopenia chemically induced, Thrombocytopenia drug therapy
Abstract: Purpose: Given the biological differences between females and males, sex-specific evaluations should be carried out to obtain better cancer prevention, diagnosis, and treatment strategies. To this purpose, our aim was to evaluate sex differences for toxicity in a cohort of colorectal cancer (CRC) patients undergoing chemotherapy., Methods: We performed a retrospective study in 329 CRC patients. Differences between males and females were tested performing the Mann-Whitney U test or the Fisher exact test. Multivariate logistic regression models were computed to evaluate the association between sex and risk of chemotherapy agent-related toxicity., Results: According association sex toxicity, significant differences were observed in the median number of episodes of nausea (p = 0.044), vomit (p = 0.007), heartburn (p = 0.022), thrombocytopenia (p = 0.005), mucositis (p = 0.024). Moreover, statistically significant differences between males and females were observed in the distribution of the highest toxicity grades of nausea (p = 0.024), heartburn (p = 0.016), and thrombocytopenia (p = 0.034). Females have an increased risk of vomit (p = 0.002), alopecia (p = 0.035), heartburn (p = 0.005), mucositis (p = 0.003), and lower risk for thrombocytopenia (p = 0.005)., Conclusion: According to the association of sex chemotherapy agent-related toxicities, females resulted on average at a significant increased risk of more common adverse events (constipation, dysgeusia, alopecia, heartburn, vomit, asthenia, nausea, pain events, and mucositis). Sex-tailored CRC chemotherapy treatment is necessary to obtain efficacy avoiding toxicity, based on patients' biological and genetic characteristics, a vision that would change CRC setting, a stable disease but still orphan of a real tailored approach., (© 2022. The Author(s).)
Published: 2022
Full Text: View/download PDF

44. Outcome of liver transplantation with grafts from brain-dead donors treated with dual hypothermic oxygenated machine perfusion, with particular reference to elderly donors.

Author: Patrono D, Cussa D, Sciannameo V, Montanari E, Panconesi R, Berchialla P, Lepore M, Gambella A, Rizza G, Catalano G, Mirabella S, Tandoi F, Lupo F, Balagna R, Salizzoni M, and Romagnoli R
Subjects: Adult, Aged, Brain, Brain Death, Graft Survival, Humans, Organ Preservation methods, Perfusion methods, Tissue Donors, Liver Transplantation methods
Abstract: Prompted by the utilization of extended criteria donors, dual hypothermic oxygenated machine perfusion (D-HOPE) was introduced in liver transplantation to improve preservation. When donors after neurological determination of death (DBD) are used, D-HOPE effect on graft outcomes is unclear. To assess D-HOPE value in this setting and to identify ideal scenarios for its use, data on primary adult liver transplant recipients from January 2014 to April 2021 were analyzed using inverse probability of treatment weighting, comparing outcomes of D-HOPE-treated grafts (n = 121) with those preserved by static cold storage (n = 723). End-ischemic D-HOPE was systematically applied since November 2017 based on donor and recipient characteristics and transplant logistics. D-HOPE use was associated with a significant reduction of early allograft failure (OR: 0.24; 0.83; p = .024), grade ≥3 complications (OR: 0.57; p = .046), comprehensive complication index (-7.20 points; p = .003), and improved patient and graft survival. These results were confirmed in the subset of elderly donors (>75-year-old). Although D-HOPE did not reduce the incidence of biliary complications, its use was associated with a reduced severity of ischemic cholangiopathy. In conclusion, D-HOPE improves postoperative outcomes and reduces early allograft loss in extended criteria DBD grafts., (© 2022 The Authors. American Journal of Transplantation published by Wiley Periodicals LLC on behalf of The American Society of Transplantation and the American Society of Transplant Surgeons.)
Published: 2022
Full Text: View/download PDF

45. Primary hyperoxaluria in Italy: the past 30 years and the near future of a (not so) rare disease.

Author: Mandrile G, Pelle A, Sciannameo V, Benetti E, D'Alessandro MM, Emma F, Montini G, Peruzzi L, Petrarulo M, Romagnoli R, Vitale C, Cellini B, and Giachino D
Subjects: Adolescent, Delayed Diagnosis, Humans, Mutation, Rare Diseases, Hyperoxaluria, Primary diagnosis, Hyperoxaluria, Primary epidemiology, Hyperoxaluria, Primary genetics, Nephrolithiasis genetics
Abstract: Background: Primary hyperoxalurias (PHs) are rare autosomal recessive diseases of the glyoxylate metabolism; PH1 is caused by mutations in the AGXT gene, PH2 in GRHPR and PH3 in HOGA1., Methods: Here we report the first large multi-center cohort of Italian PH patients collected over 30 years (1992-2020 median follow-up time 8.5 years). Complete genotype was available for 94/95 PH1 patients and for all PH2 (n = 3) and PH3 (n = 5) patients. Symptoms at onset were mainly nephrolithiasis (46.3%) and nephrocalcinosis (33.7%). Median age at onset of symptoms and diagnosis were 4.0 years and 9.9 years, respectively., Results: Fifty-four patients (56.8%) were diagnosed after chronic kidney disease. Sixty-three patients (66.3%) developed end stage kidney disease (median age 14.0 years). Twenty-one patients had a kidney-only transplant and, among them, seven had a second kidney transplant combined with liver transplant. A combined kidney-liver transplant was carried out in 29 patients and a sequential kidney-liver transplant was performed in two. In five cases a preemptive liver transplant was performed. Those receiving a liver-only transplant tended to have lower kidney function at last follow-up., Conclusion: Our study of PHs in Italy underlines a considerable diagnostic delay, which has only slightly decreased in recent years. Therefore, we suggest a more extensive use of both metabolic screening among patients with recurrent kidney stones and genotyping, including unambiguous assignment of minor/major allele status in order to promptly begin appropriate treatment. This will be fundamental in order to have access to the new therapies, which are mainly focused on substrate reduction for the oxalate-producing enzymes using RNA-interference., (© 2022. The Author(s).)
Published: 2022
Full Text: View/download PDF

46. Prediction of treatment outcome in clinical trials under a personalized medicine perspective.

Author: Berchialla P, Lanera C, Sciannameo V, Gregori D, and Baldi I
Subjects: Humans, Machine Learning, Randomized Controlled Trials as Topic, Treatment Outcome, Diabetes Mellitus, Type 2 drug therapy, Precision Medicine
Abstract: A central problem in most data-driven personalized medicine scenarios is the estimation of heterogeneous treatment effects to stratify individuals into subpopulations that differ in their susceptibility to a particular disease or response to a specific treatment. In this work, with an illustrative example on type 2 diabetes we showed how the increasing ability to access and analyzed open data from randomized clinical trials (RCTs) allows to build Machine Learning applications in a framework of personalized medicine. An ensemble machine learning predictive model is first developed and then applied to estimate the expected treatment response according to the medication that would be prescribed. Machine learning is quickly becoming indispensable to bridge science and clinical practice, but it is not sufficient on its own. A collaborative effort is requested to clinicians, statisticians, and computer scientists to strengthen tools built on machine learning to take advantage of this evidence flow., (© 2022. The Author(s).)
Published: 2022
Full Text: View/download PDF

47. Exploring the Use and Usefulness of Educational Resources Among Nurses During the First Wave of the COVID-19 Pandemic: A Cross-Sectional Study.

Author: Conti A, Clari M, Luciani M, Sciannameo V, Berchialla P, Dimonte V, and Campagna S
Subjects: Cross-Sectional Studies, Humans, Learning, SARS-CoV-2, COVID-19, Pandemics
Abstract: Nurses needed to learn rapidly how to care for patients with coronavirus disease 2019 (COVID-19). This cross-sectional study identified the educational resources RNs used to learn how to care for these patients, measured the perceived usefulness of the content of these resources, and explored the most relevant educational content sought during the first wave of the pandemic. A total of 799 RNs completed an online survey. Significant differences were found in the educational resources used between RNs who cared for patients with COVID-19 and RNs who did not, as well as for RNs who changed units following the pandemic. The educational resources most often used were also ranked as most useful. The most relevant educational content sought was related to respiratory care techniques and infection containment. These findings provide insight into the educational resources available during the first wave of the COVID-19 pandemic. They could help in developing educational programs relevant to nurses' needs during future pandemics. [ J Contin Educ Nurs . 2022;53(2):63-69.] .
Published: 2022
Full Text: View/download PDF

48. The effect of COVID-19 on scientific publishing in Italy.

Author: Berchialla P, Urru S, and Sciannameo V
Subjects: Bibliometrics, Humans, Italy, Publishing, SARS-CoV-2, COVID-19
Published: 2021
Full Text: View/download PDF

49. The Impact of the COVID-19 Pandemic on Nursing Care: A Cross-Sectional Survey-Based Study.

Author: Clari M, Luciani M, Conti A, Sciannameo V, Berchialla P, Di Giulio P, Campagna S, and Dimonte V
Abstract: The COVID-19 pandemic has had a severe impact on nursing care. This cross-sectional survey-based study compared aspects of nursing care and nurses' satisfaction with care provided before and during the first wave of the COVID-19 pandemic. A total of 936 registered nurses (RNs) rated the frequency with which they performed fundamental care, nursing techniques, patient education, symptom management, and nurse-patient relationships before and during the pandemic. A recursive partitioning for ordered multivariate response in a conditional inference framework approach was applied. More frequent fundamental cares were associated with their frequency before the pandemic ( p < 0.001), caring for COVID-19 patients ( p < 0.001), and workplace reassignment ( p = 0.004). Caring for COVID-19 patients ( p < 0.001), workplace reassignment ( p = 0.030), and caring for ≤7.4 COVID-19 patients ( p = 0.014) increased nursing techniques. RNs in high-intensity COVID-19 units ( p = 0.002) who educated patients before the pandemic, stopped this task. RNs caring for COVID-19 patients reported increased symptom management ( p < 0.001), as did RNs caring for more non-COVID-19 patients ( p = 0.037). Less frequent nurse-patient relationships before the pandemic and working in high-intensity COVID-19 units decreased nurse-patient relationships ( p = 0.002). Despite enormous challenges, nurses continued to provide a high level of care. Ensuring the appropriate deployment and education of nurses is crucial to personalize care and to maintain nurses' satisfaction with the care provided.
Published: 2021
Full Text: View/download PDF

50. Incidence and Prevalence Analysis of Non-Small-Cell and Small-Cell Lung Cancer Using Administrative Data.

Author: Ricotti A, Sciannameo V, Balzi W, Roncadori A, Canavese P, Avitabile A, Massa I, and Berchialla P
Subjects: Humans, Incidence, Prevalence, Carcinoma, Non-Small-Cell Lung epidemiology, Lung Neoplasms epidemiology, Small Cell Lung Carcinoma epidemiology
Abstract: Treatment of lung cancer depends on the stage of the tumor and the histological type. In recent years, the histological confirmation of lung non-small-cell lung cancer has become crucial since the availability of selective target therapeutic approaches. The aim of the study was to develop a validated procedure to estimate the incidence and prevalence of non-small-cell and small-cell lung cancer from healthcare administrative data. A latent class model for categorical variables was applied. The following observed variables were included in the analysis: ICD-9-CM codes in the Hospital Discharge Registry, ATC codes of medications dispensed present in the Drugs Prescriptions Registry, and the procedure codes in the Outpatient Registry. The proportion of non-small-cell lung cancer diagnoses was estimated to be 85% of the total number of lung cancer on the cohort of incident cases and 89% on the cohort of prevalent cases. External validation on a cohort of 107 patients with a lung cancer diagnosis and histological confirmation showed a sensitivity of 95.6% (95%CI: 89-98.8%) and specificity of 94.1% (95%CI: 71.3-99.9%). The procedure is an easy-to-use tool to design subpopulation-based studies on lung cancer and to better plan resource allocation, which is important since the introduction of new targeted therapies in non-small-cell lung carcinoma.
Published: 2021
Full Text: View/download PDF

Catalog

Books, media, physical & digital resources

See catalog results

Searchworks

Select search scope, currently: Articles Catalog books, media & more in Jio Institute collections Articles journal articles & other e-resources

Search

Search Constraints

Refine your results

Search Limiters

Topic

Publication Year Range

Language

Publication Type

Journal

Region

Database

Publisher

95 results on '"Sciannameo, V."'

Search Results

Catalog

Select search scope, currently: Articles

Catalog

books, media & more in Jio Institute collections

Articles

journal articles & other e-resources