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1. Trends in short-term survival from distant-stage cutaneous melanoma in the United States, 2001-2013 (CONCORD-3)

Author

Di Carlo, Veronica, Estève, Jacques, Johnson, Christopher, Girardi, Fabio, Weir, Hannah K, Wilson, Reda J, Minicozzi, Pamela, Cress, Rosemary D, Lynch, Charles F, Pawlish, Karen S, Rees, Judith R, Coleman, Michel P, Allemani, Claudia, Group, CONCORD Working, Freeman, T, George, JT, Avila, RM, O'Brien, DK, Holt, A, Almon, L, Kwong, S, Morris, C, Rycroft, R, Mueller, L, Phillips, CE, Cromartie, B, Schwartz, AG, Vigneau, F, Levin, GM, Wohler, B, Bayakly, R, Ward, KC, Gomez, SL, McKinley, M, Cress, R, Green, MD, Miyagi, K, Johnson, CJ, Ruppert, LP, Lynch, CF, Huang, B, Tucker, TC, Deapen, D, Liu, L, Hsieh, MC, Wu, XC, Schwenn, M, Stern, K, Gershman, ST, Knowlton, RC, Alverson, G, Weaver, T, Bushhouse, S, Rogers, DB, Jackson-Thompson, J, Lemons, D, Zimmerman, HJ, Hood, M, Roberts-Johnson, J, Rees, JR, Riddle, B, Pawlish, KS, Stroup, A, Key, C, Wiggins, C, Kahn, AR, Schymura, MJ, Radhakrishnan, S, Rao, C, Giljahn, LK, Slocumb, RM, Espinoza, RE, Khan, F, Aird, KG, Beran, T, Rubertone, JJ, Slack, SJ, Oh, J, Janes, TA, Schwartz, SM, Bolick, SW, Hurley, DM, Whiteside, MA, Miller-Gianturco, P, Williams, MA, Herget, K, Sweeney, C, Johnson, AT, Cheteri, MB Keitheri, Santiago, P Migliore, Blankenship, SE, Farley, S, Borchers, R, Malicki, R, Espinoza, JR, Grandpre, J, Weir, HK, Wilson, R, Edwards, BK, and Mariotto, A

Subjects
Cancer, US CONCORD Working Group
Abstract

BackgroundSurvival from metastatic cutaneous melanoma is substantially lower than for localized disease. Treatments for metastatic melanoma have been limited, but remarkable clinical improvements have been reported in clinical trials in the last decade. We described the characteristics of US patients diagnosed with cutaneous melanoma during 2001-2013 and assessed trends in short-term survival for distant-stage disease.MethodsTrends in 1-year net survival were estimated using the Pohar Perme estimator, controlling for background mortality with life tables of all-cause mortality rates by county of residence, single year of age, sex, and race for each year 2001-2013. We fitted a flexible parametric survival model on the log-hazard scale to estimate the effect of race on the hazard of death because of melanoma and estimated 1-year net survival by race.ResultsOnly 4.4% of the 425 915 melanomas were diagnosed at a distant stage, cases diagnosed at a distant stage are more commonly men, older patients, and African Americans. Age-standardized, 1-year net survival for distant-stage disease was stable at approximately 43% during 2001-2010. From 2010 onward, survival improved rapidly, reaching 58.9% (95% confidence interval = 56.6% to 61.2%) for patients diagnosed in 2013. Younger patients experienced the largest improvement. Survival for distant-stage disease increased in both Blacks and Whites but was consistently lower in Blacks.ConclusionsOne-year survival for distant-stage melanoma improved during 2001-2013, particularly in younger patients and those diagnosed since 2010. This improvement may be a consequence of the introduction of immune-checkpoint-inhibitors and other targeted treatments for metastatic and unresectable disease. Persistent survival inequalities exist between Blacks and Whites, suggesting differential access to treatment.

Published
2020

2. International incidence of childhood cancer, 2001–10: a population-based registry study

Author

Bouzbid, S, Hamdi-Cherif, M, Hablas, A, Chirpaz, E, Buziba, N, Chesumbai, GC, Manraj, SS, Reynders, D, Wabinga, HR, Chokunonga, E, Moreno, F, Lima, CA, Asturian Laporte, C, de Oliveira, JC, de Aquino, JA Pontes, Gallagher, SM Vargas, Uribe, CJ, Bravo, LE, Yepez Chamorro, MC, Torres Alvarado, G, Galán Alvarez, YH, Martinez Reyes, FC, Castillo Calvas, JC, Mendoza Alava, M, Cueva Ayala, P, Hanchard, B, Fajardo-Gutiérrez, A, Zavala Zegarra, DE, Barrios, E, Nikiforuk, C, Woods, R, Turner, D, MacIntyre, M, Corriveau, A, Navaneelan, T, Bertrand, C, Stuart-Panko, H, Wilson, RJ, Kosary, C, Shen, X, Brockhouse, J, Yee, GA, Mitchell, TC, Snipes, K, West, D, Rao, C, Bolick, S, Rycroft, RK, Mueller, L, Zheng, Y, Dosch, K, Brown, H, Vargas, A, Levin, GM, Bayakly, R, Johnson, C, Shen, T, Ruppert, L, Lynch, CF, Lai, SM, Tucker, TC, Wu, XC, Schwenn, M, Stern, K, Gershman, S, Copeland, G, Bushhouse, S, Rogers, DB, Jackson Thompson, J, Lemons, D, Frederick, S, Harris, JA, Riddle, B, Stroup, A, Wiggins, C, Schymura, MJ, Giljahn, LK, Sheikh, A, Schubert, S, Aldinger, W, Fulton, JP, Whiteside, M, Nogueira, L, Sweeney, C, Johnson, A, Martin, J, Farley, S, Harrelson, D, Malicki, R, Espinoza, JR, Hernandez, BY, Abulfateh, N, Wang, N, Ngan, RKC, Lingegowda, KB, Swaminathan, R, Koyande, SS, Silverman, B, Ozasa, K, Kanemura, S, Soda, M, Miyashiro, I, Shibata, A, Nimri, O, Won, YJ, Kim, CH, Hong, NS, Nam, HS, Kweon, S, Kim, WC, Huh, JS, Jung, KW, Yoo, CI, Elbasmy, A, Laudico, AV, Lumague, MR, AlMutlag, H, Buasom, R, Srisukho, S, Tanabodee, J, Wiangnon, S, Pongnikorn, D, Sriplung, H, Dirican, O, Eser, S, Le Hoang, M, Hackl, M, Zborovskaya, A, Dimitrova, N, Valerianova, Z, Sekerija, M, Pavlou, P, Dušek, M, Mägi, M, Clavel, J, Lacour, B, Guizard, AV, Bouvier, V, Troussard, X, Woronoff, AS, Tretarre, B, Colonna, M, Molinié, F, Bara, S, Velten, M, Marrer, E, Ganry, O, Grosclaude, P, Kaatsch, P, Zeissig, SR, Holleczek, B, Katalinic, A, Jakab, Z, Birgisson, H, Walsh, PM, Mangone, L, Merletti, F, Magoni, M, Ferretti, S, Serraino, D, Spagnoli, G, Fusco, M, Michiara, M, Tumino, R, Falcini, F, Sensi, F, Tisano, F, Piffer, S, Stracci, F, Tagliabue, G, Smailyte, G, Agius, D, Visser, O, Ursin, G, Didkowska, J, Trojanowski, M, Wojciechowska, U, Forjaz de Lacerda, G, Silva, MA, Laranja Pontes, J, da Costa Miranda, A, Kaiserova, E, Primic Žakelj, M, Peris-Bonet, R, Vicente Raneda, ML, Almar Marqués, E, Quirós Garcia, JR, Ramos Monserrat, M, Errezola Saizar, M, Alemán Herrera, A, Díaz García, JM, Marcos-Gragera, R, Sanchez-Perez, MJ, Ardanaz Aicua, E, Galceran, J, Klint, A, Kuehni, CE, Bouchardy, C, Levi, F, Bordoni, A, Konzelmann, I, Rohrmann, S, Stiller, CA, Gavin, AT, Brewster, DH, Phung, H, Rushton, S, Guthridge, S, Aitken, J, D'Onise, K, Venn, A, Farrugian, H, Threlfall, TJ, Laumond, S, Yen Kai Sun, L, Hendrix, J, Ballantine, K, Colombet, M, Dolya, A, Masuyer, E, Steliarova-Foucher, E, Steliarova-Foucher, Eva, Colombet, Murielle, Ries, Lynn A G, Moreno, Florencia, Dolya, Anastasia, Bray, Freddie, Hesseling, Peter, Shin, Hee Young, and Stiller, Charles A

Published
2017
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3. The histology of brain tumors for 67 331 children and 671 085 adults diagnosed in 60 countries during 2000-2014: a global, population-based study (CONCORD-3)

Author

Girardi, Fabio;Rous, Brian;Stiller, Charles A;Gatta, Gemma;Fersht, Naomi;Storm, Hans H;Rodrigues, Jessica R;Herrmann, Christian;Marcos-Gragera, Rafael;Peris-Bonet, Rafael;Valkov, Mikhail;Weir, Hannah K;Woods, Ryan R;You, Hui;Cueva, Patricia A;De, Prithwish;Di Carlo, Veronica;Johannesen, Tom Børge;Lima, Carlos A;Lynch, Charles F;Coleman, Michel P;Allemani, Claudia;Bouzbid, S;Hamdi-Chérif, M;Zaidi, Z;Meguenni, K;Regagba, D;Bayo, S;Cheick Bougadari, T;Manraj, S S;Bendahhou, K;Ladipo, A;Ogunbiyi, O J;Ramaliba, T;Somdyala, N I M;Chaplin, M A;Moreno, F;Calabrano, G H;Espinola, S B;Carballo Quintero, B;Fita, R;Laspada, W D;Ibañez, S G;Lima, C A;Mafra da Costa, A;De Souza, P C F;Del Pino, K;Laporte, C;Curado, M P;de Oliveira, J C;Veneziano, C L A;Veneziano, D B;Latorre, M R D O;Tanaka, L F;Rebelo, M S;Santos, M O;Azevedo e Silva, G;Galaz, J C;Aparicio Aravena, M;Sanhueza Monsalve, J;Herrmann, D A;Vargas, S;Herrera, V M;Uribe, C J;Bravo, L E;Garcia, L S;Arias-Ortiz, N E;Morantes, D;Jurado, D M;Yépez Chamorro, M C;Delgado, S;Ramirez, M;Galán Alvarez, Y H;Torres, P;Martínez-Reyes, F;Jaramillo, L;Quinto, R;Castillo, J;Mendoza, M;Cueva, P;Yépez, J G;Bhakkan, B;Deloumeaux, J;Joachim, C;Macni, J;Carrillo, R;Shalkow Klincovstein, J;Rivera Gomez, R;Perez, P;Poquioma, E;Tortolero-Luna, G;Zavala, D;Alonso, R;Barrios, E;Eckstrand, A;Nikiforuk, C;Woods, R R;Noonan, G;Turner, D;Kumar, E;Zhang, B;McCrate, F R;Ryan, S;MacIntyre, M;Saint-Jacques, N;Anam, A;De, P;McClure, C A;Vriends, K A;Bertrand, C;Latreille, J;Kozie, S;Stuart-Panko, H;Freeman, T;George, J T;Avila, R M;O’Brien, D K;Holt, A;Almon, L;Kwong, S;Morris, C;Rycroft, R;Mueller, L;Phillips, C E;Brown, H;Cromartie, B;Schwartz, A G;Vigneau, F;Levin, G M;Wohler, B;Bayakly, R;Ward, K C;Gomez, S L;McKinley, M;Cress, R;Green, M D;Miyagi, K;Johnson, C J;Ruppert, L P;Bentler, S;Charlton, M E;Huang, B;Tucker, T C;Deapen, D;Liu, L;Hsieh, M C;Wu, X C;Schwenn, M;Stern, K;Gershman, S T;Knowlton, R C;Alverson, G;Weaver, T;Bushhouse, S;Rogers, D and Girardi, Fabio;Rous, Brian;Stiller, Charles A;Gatta, Gemma;Fersht, Naomi;Storm, Hans H;Rodrigues, Jessica R;Herrmann, Christian;Marcos-Gragera, Rafael;Peris-Bonet, Rafael;Valkov, Mikhail;Weir, Hannah K;Woods, Ryan R;You, Hui;Cueva, Patricia A;De, Prithwish;Di Carlo, Veronica;Johannesen, Tom Børge;Lima, Carlos A;Lynch, Charles F;Coleman, Michel P;Allemani, Claudia;Bouzbid, S;Hamdi-Chérif, M;Zaidi, Z;Meguenni, K;Regagba, D;Bayo, S;Cheick Bougadari, T;Manraj, S S;Bendahhou, K;Ladipo, A;Ogunbiyi, O J;Ramaliba, T;Somdyala, N I M;Chaplin, M A;Moreno, F;Calabrano, G H;Espinola, S B;Carballo Quintero, B;Fita, R;Laspada, W D;Ibañez, S G;Lima, C A;Mafra da Costa, A;De Souza, P C F;Del Pino, K;Laporte, C;Curado, M P;de Oliveira, J C;Veneziano, C L A;Veneziano, D B;Latorre, M R D O;Tanaka, L F;Rebelo, M S;Santos, M O;Azevedo e Silva, G;Galaz, J C;Aparicio Aravena, M;Sanhueza Monsalve, J;Herrmann, D A;Vargas, S;Herrera, V M;Uribe, C J;Bravo, L E;Garcia, L S;Arias-Ortiz, N E;Morantes, D;Jurado, D M;Yépez Chamorro, M C;Delgado, S;Ramirez, M;Galán Alvarez, Y H;Torres, P;Martínez-Reyes, F;Jaramillo, L;Quinto, R;Castillo, J;Mendoza, M;Cueva, P;Yépez, J G;Bhakkan, B;Deloumeaux, J;Joachim, C;Macni, J;Carrillo, R;Shalkow Klincovstein, J;Rivera Gomez, R;Perez, P;Poquioma, E;Tortolero-Luna, G;Zavala, D;Alonso, R;Barrios, E;Eckstrand, A;Nikiforuk, C;Woods, R R;Noonan, G;Turner, D;Kumar, E;Zhang, B;McCrate, F R;Ryan, S;MacIntyre, M;Saint-Jacques, N;Anam, A;De, P;McClure, C A;Vriends, K A;Bertrand, C;Latreille, J;Kozie, S;Stuart-Panko, H;Freeman, T;George, J T;Avila, R M;O’Brien, D K;Holt, A;Almon, L;Kwong, S;Morris, C;Rycroft, R;Mueller, L;Phillips, C E;Brown, H;Cromartie, B;Schwartz, A G;Vigneau, F;Levin, G M;Wohler, B;Bayakly, R;Ward, K C;Gomez, S L;McKinley, M;Cress, R;Green, M D;Miyagi, K;Johnson, C J;Ruppert, L P;Bentler, S;Charlton, M E;Huang, B;Tucker, T C;Deapen, D;Liu, L;Hsieh, M C;Wu, X C;Schwenn, M;Stern, K;Gershman, S T;Knowlton, R C;Alverson, G;Weaver, T;Bushhouse, S;Rogers, D

Published
2020

6. International incidence of childhood cancer, 2001-10 a population-based registry study

Author

Steliarova Foucher Eva, Colombet, Murielle, Ries Lynn, A. G., Moreno, Florencia, Dolya, Anastasia, Bray, Freddie, Hesseling, Peter, Shin, Hee Young Stiller, Iicc, 3 contributors, Bouzbid, S, Hamdi Cherif, M, Hablas, A, Chirpaz, E, Buziba, N, Chesumbai, Gc, Manraj, Ss, Reynders, D, Wabinga, Hr, Chokunonga, E, Moreno, F, Lima, Ca, Asturian Laporte, C, de Oliveira JC, de Aquino JP, Gallagher, Sv, Uribe, Cj, Bravo, Le, Yepez Chamorro MC, Torres Alvarado, G, Galán Alvarez YH, Martinez Reyes FC, Castillo Calvas JC, Mendoza Alava, M, Cueva Ayala, P, Hanchard, B, Fajardo Gutiérrez, A, Zavala Zegarra DE, Barrios, E, Nikiforuk, C, Woods, R, Turner, D, Macintyre, M, Corriveau, A, Navaneelan, T, Bertrand, C, Stuart Panko, H, Wilson, Rj, Kosary, C, Shen, X, Brockhouse, J, Yee, Ga, Mitchell, Tc, Snipes, K, West, D, Rao, C, Bolick, S, Rycroft, Rk, Mueller, L, Zheng, Y, Dosch, K, Brown, H, Vargas, A, Levin, Gm, Bayakly, R, Johnson, C, Shen, T, Ruppert, L, Lynch, Cf, Lai, Sm, Tucker, Tc, Wu, Xc, Schwenn, M, Stern, K, Gershman, S, Copeland, G, Bushhouse, S, Rogers, Db, Jackson Thompson, J, Lemons, D, Frederick, S, Harris, Ja, Riddle, B, Stroup, A, Wiggins, C, Schymura, Mj, Giljahn, Lk, Sheikh, A, Schubert, S, Aldinger, W, Fulton, Jp, Whiteside, M, Nogueira, L, Sweeney, C, Johnson, A, Martin, J, Farley, S, Harrelson, D, Malicki, R, Espinoza, Jr, Hernandez, By, Abulfateh, N, Wang, N, Ngan, R, Lingegowda, Kb, Swaminathan, R, Koyande, Ss, Silverman, B, Ozasa, K, Kanemura, S, Soda, M, Miyashiro, I, Shibata, A, Nimri, O, Won, Yj, Kim, Ch, Hong, Ns, Nam, Hs, Kweon, S, Kim, Wc, Huh, Js, Jung, Kw, Yoo, Ci, Elbasmy, A, Laudico, Av, Lumague, Mr, Almutlag, H, Buasom, R, Srisukho, S, Tanabodee, J, Wiangnon, S, Pongnikorn, D, Sriplung, H, Dirican, O, Eser, S, Le Hoang, M, Hackl, M, Zborovskaya, A, Dimitrova, N, Valerianova, Z, Sekerija, M, Pavlou, P, Dušek, M, Mägi, M, Clavel, J, Lacour, B, Guizard, Av, Bouvier, V, Troussard, X, Woronoff, As, Tretarre, B, Colonna, M, Molinié, F, Bara, S, Velten, M, Marrer, E, Ganry, O, Grosclaude, P, Kaatsch, P, Zeissig, Sr, Holleczek, B, Katalinic, A, Jakab, Z, Birgisson, H, Walsh, Pm, Mangone, L, Merletti, Franco, Magoni, M, Ferretti, S, Serraino, D, Spagnoli, G, Fusco, M, Michiara, M, Tumino, R, Falcini, F, Sensi, F, Tisano, F, Piffer, S, Stracci, F, Tagliabue, G, Smailyte, G, Agius, D, Visser, O, Ursin, G, Didkowska, J, Trojanowski, M, Wojciechowska, U, Forjaz de Lacerda, G, Silva, Ma, Laranja Pontes, J, da Costa Miranda, A, Kaiserova, E, Primic Žakelj, M, Peris Bonet, R, Vicente Raneda ML, Almar Marqués, E, Quirós Garcia JR, Ramos Monserrat, M, Errezola Saizar, M, Alemán Herrera, A, Díaz García JM, Marcos Gragera, R, Sanchez Perez MJ, Ardanaz Aicua, E, Galceran, J, Klint, A, Kuehni, Ce, Bouchardy, C, Levi, F, Bordoni, A, Konzelmann, I, Rohrmann, S, Stiller, Ca, Gavin, At, Brewster, Dh, Phung, H, Rushton, S, Guthridge, S, Aitken, J, D'Onise, K, Venn, A, Farrugian, H, Threlfall, Tj, Laumond, S, Yen Kai Sun, L, Hendrix, J, Ballantine, K, Colombet, M, Dolya, A, Masuyer, E, Steliarova Foucher, E., IICC-3 contributors, Bouzbid, S., Hamdi-Cherif, M., Hablas, A., Chirpaz, E., Buziba, N., Chesumbai, G.C., Manraj, S.S., Reynders, D., Wabinga, H.R., Chokunonga, E., Moreno, F., Lima, C.A., Asturian Laporte, C., de Oliveira, J.C., de Aquino, J.P., Gallagher, S.V., Uribe, C.J., Bravo, L.E., Yepez Chamorro, M.C., Torres Alvarado, G., Galán Alvarez, Y.H., Martinez Reyes, F.C., Castillo Calvas, J.C., Mendoza Alava, M., Cueva Ayala, P., Hanchard, B., Fajardo-Gutiérrez, A., Zavala Zegarra, D.E., Barrios, E., Nikiforuk, C., Woods, R., Turner, D., MacIntyre, M., Corriveau, A., Navaneelan, T., Bertrand, C., Stuart-Panko, H., Wilson, R.J., Kosary, C., Shen, X., Brockhouse, J., Yee, G.A., Mitchell, T.C., Snipes, K., West, D., Rao, C., Bolick, S., Rycroft, R.K., Mueller, L., Zheng, Y., Dosch, K., Brown, H., Vargas, A., Levin, G.M., Bayakly, R., Johnson, C., Shen, T., Ruppert, L., Lynch, C.F., Lai, S.M., Tucker, T.C., Wu, X.C., Schwenn, M., Stern, K., Gershman, S., Copeland, G., Bushhouse, S., Rogers, D.B., Jackson Thompson, J., Lemons, D., Frederick, S., Harris, J.A., Riddle, B., Stroup, A., Wiggins, C., Schymura, M.J., Giljahn, L.K., Sheikh, A., Schubert, S., Aldinger, W., Fulton, J.P., Whiteside, M., Nogueira, L., Sweeney, C., Johnson, A., Martin, J., Farley, S., Harrelson, D., Malicki, R., Espinoza, J.R., Hernandez, B.Y., Abulfateh, N., Wang, N., Ngan, R., Lingegowda, K.B., Swaminathan, R., Koyande, S.S., Silverman, B., Ozasa, K., Kanemura, S., Soda, M., Miyashiro, I., Shibata, A., Nimri, O., Won, Y.J., Kim, C.H., Hong, N.S., Nam, H.S., Kweon, S., Kim, W.C., Huh, J.S., Jung, K.W., Yoo, C.I., Elbasmy, A., Laudico, A.V., Lumague, M.R., AlMutlag, H., Buasom, R., Srisukho, S., Tanabodee, J., Wiangnon, S., Pongnikorn, D., Sriplung, H., Dirican, O., Eser, S., Le Hoang, M., Hackl, M., Zborovskaya, A., Dimitrova, N., Valerianova, Z., Sekerija, M., Pavlou, P., Dušek, M., Mägi, M., Clavel, J., Lacour, B., Guizard, A.V., Bouvier, V., Troussard, X., Woronoff, A.S., Tretarre, B., Colonna, M., Molinié, F., Bara, S., Velten, M., Marrer, E., Ganry, O., Grosclaude, P., Kaatsch, P., Zeissig, S.R., Holleczek, B., Katalinic, A., Jakab, Z., Birgisson, H., Walsh, P.M., Mangone, L., Merletti, F., Magoni, M., Ferretti, S., Serraino, D., Spagnoli, G., Fusco, M., Michiara, M., Tumino, R., Falcini, F., Sensi, F., Tisano, F., Piffer, S., Stracci, F., Tagliabue, G., Smailyte, G., Agius, D., Visser, O., Ursin, G., Didkowska, J., Trojanowski, M., Wojciechowska, U., Forjaz de Lacerda, G., Silva, M.A., Laranja Pontes, J., da Costa Miranda, A., Kaiserova, E., Primic Žakelj, M., Peris-Bonet, R., Vicente Raneda, M.L., Almar Marqués, E., Quirós Garcia, J.R., Ramos Monserrat, M., Errezola Saizar, M., Alemán Herrera, A., Díaz García, J.M., Marcos-Gragera, R., Sanchez-Perez, M.J., Ardanaz Aicua, E., Galceran, J., Klint, A., Kuehni, C.E., Bouchardy, C., Levi, F., Bordoni, A., Konzelmann, I., Rohrmann, S., Stiller, C.A., Gavin, A.T., Brewster, D.H., Phung, H., Rushton, S., Guthridge, S., Aitken, J., D'Onise, K., Venn, A., Farrugian, H., Threlfall, T.J., Laumond, S., Yen Kai Sun, L., Hendrix, J., Ballantine, K., Colombet, M., Dolya, A., Masuyer, E., Steliarova-Foucher, E., University of Zurich, and Steliarova-Foucher, Eva

Subjects
0301 basic medicine, Male, Pediatrics, cancer incidence, sistema de registros, humanos, Ethnic group, adolescente, population-based registry study, North America/epidemiology, 0302 clinical medicine, Neoplasms, Medicine, Registries, Young adult, Child, Cancer in children -- Mortality, Cause of death, neoplasias, education.field_of_study, Incidence (epidemiology), Incidence, South America/epidemiology, Articles, Càncer en els infants -- Mortalitat, incidence, cancer registry, childhood cancer, 3. Good health, adulto joven, Caribbean Region/epidemiology, Oncology, Oceania/epidemiology, 030220 oncology & carcinogenesis, Child, Preschool, Oncology, childhood, cancer, population-based registry study, cancer incidence, 2730 Oncology, Female, medicine.medical_specialty, Oceanía, Adolescent, Oceania, Population, Socio-culturale, 610 Medicine & health, incidencia, Europe/epidemiology, 03 medical and health sciences, Young Adult, Age Distribution, distribución por edades, SDG 3 - Good Health and Well-being, cancer, Humans, education, childhood, lactante, Asia/epidemiology, business.industry, Cancer, Infant, 10060 Epidemiology, Biostatistics and Prevention Institute (EBPI), medicine.disease, Cancer registry, 030104 developmental biology, Africa/epidemiology, business, Neoplasms/epidemiology, International Classification of Diseases for Oncology, Demography
Abstract

Background Cancer is a major cause of death in children worldwide, and the recorded incidence tends to increase with time. Internationally comparable data on childhood cancer incidence in the past two decades are scarce. This study aimed to provide internationally comparable local data on the incidence of childhood cancer to promote research of causes and implementation of childhood cancer control. Methods This population-based registry study, devised by the International Agency for Research on Cancer in collaboration with the International Association of Cancer Registries, collected data on all malignancies and nonmalignant neoplasms of the CNS diagnosed before age 20 years in populations covered by high-quality cancer registries with complete data for 2001-10. Incidence rates per million person-years for the 0-14 years and 0-19 years age groups were age-adjusted using the world standard population to provide age-standardised incidence rates (WSRs), using the age-specific incidence rates (ASR) for individual age groups (0-4 years, 5-9 years, 10-14 years, and 15-19 years). All rates were reported for 19 geographical areas or ethnicities by sex, age group, and cancer type. The regional WSRs for children aged 0-14 years were compared with comparable data obtained in the 1980s. Findings Of 532 invited cancer registries, 153 registries from 62 countries, departments, and territories met quality standards, and contributed data for the entire decade of 2001-10. 385 509 incident cases in children aged 0-19 years occurring in 2.64 billion person-years were included. The overall WSR was 140.6 per million person-years in children aged 0-14 years (based on 284 649 cases), and the most common cancers were leukaemia (WSR 46.4), followed by CNS tumours (WSR 28.2), and lymphomas (WSR 15.2). In children aged 15-19 years (based on 100 860 cases), the ASR was 185.3 per million person-years, the most common being lymphomas (ASR 41.8) and the group of epithelial tumours and melanoma (ASR 39.5). Incidence varied considerably between and within the described regions, and by cancer type, sex, age, and racial and ethnic group. Since the 1980s, the global WSR of registered cancers in children aged 0-14 years has increased from 124.0 (95% CI 123.3-124.7) to 140.6 (140.1-141.1) per million person-years. Interpretation This unique global source of childhood cancer incidence will be used for aetiological research and to inform public health policy, potentially contributing towards attaining several targets of the Sustainable Development Goals. The observed geographical, racial and ethnic, age, sex, and temporal variations require constant monitoring and research., International Agency for Research on Cancer and the Union for International Cancer Control.

Published
2017

8. Interaktion von vier genetischen Risikovarianten für das Harnblasenkarzinom

Author

Selinski, S, Blaszkewicz, M, Ickstadt, K, Gerullis, H, Otto, T, Roth, E, Volkert, F, Ovsiannikov, D, Moormann, O, Banfi, G, Nyirady, P, Vermeulen, SH, Garcia-Closas, M, Figueroa, JD, Johnson, A, Karagas, MR, Kogevinas, M, Malats, N, Schwenn, M, Silverman, DT, Koutros, S, Rothman, N, Kiemeney, LA, Hengstler, JG, Golka, K, Selinski, S, Blaszkewicz, M, Ickstadt, K, Gerullis, H, Otto, T, Roth, E, Volkert, F, Ovsiannikov, D, Moormann, O, Banfi, G, Nyirady, P, Vermeulen, SH, Garcia-Closas, M, Figueroa, JD, Johnson, A, Karagas, MR, Kogevinas, M, Malats, N, Schwenn, M, Silverman, DT, Koutros, S, Rothman, N, Kiemeney, LA, Hengstler, JG, and Golka, K

Published
2018

9. Bewertung der Messunsicherheit bei der Durchführung von Dauerlastversuchen mit Verbunddübeln.

Author

Stierschneider, E., Schwenn, M., Zeman, O., and Bergmeister, K.

Subjects
*FASTENERS, *TENSION loads, *PRODUCTIVE life span, *MONEY, *DISPLACEMENT (Mechanics)
Abstract

Sustained load tests are necessary for product‐qualification of bonded fasteners. The aim of these sustained load tests is the evaluation of the fastening under constant tension load. Based on these tests, an extrapolation of the displacement behaviour concerning the assumed working life of the fastening is carried out. Three different measurands are of interest for sustained load tests, which are the failure load during the tension tests, the constancy of the applied sustained load, as well as the displacement. Due to the fact that every measurand is tainted with measurement uncertainty, the present paper aimed to evaluate the dimension of the expected measurement uncertainty, since this influences in consequence the forecast of the displacement behaviour over the working life of a bonded fastener. The assessment is done in accordance with the „Guide to the expression of Uncertainty in Measurement" for both, the maximum expected measurement uncertainty in compliance with the accuracy requirements of the relevant testing standards and with values from practice for the purpose of comparison. [ABSTRACT FROM AUTHOR]

Published
2020
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10. Interplay of four genetic high risk variants for urinary bladder cancer

Author

Selinski, S., primary, Ickstadt, K., additional, Gerullis, H., additional, Otto, T., additional, Roth, E., additional, Volkert, F., additional, Ovsiannikov, D., additional, Moormann, O., additional, Banfi, G., additional, Nyirady, P., additional, Vermeulen, S.H., additional, Garcia-Closas, M., additional, Figueroa, J.D., additional, Johnson, A., additional, Karagas, M.R., additional, Kogevinas, M., additional, Malats, N., additional, Schwenn, M., additional, Silverman, D.T., additional, Koutros, S., additional, Rothman, N., additional, Kiemeney, L.A., additional, Hengstler, J.G., additional, and Golka, K., additional

Published
2018
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11. Global surveillance of trends in cancer survival 2000–14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries

Author

Allemani, Claudia, primary, Matsuda, Tomohiro, additional, Di Carlo, Veronica, additional, Harewood, Rhea, additional, Matz, Melissa, additional, Nikšić, Maja, additional, Bonaventure, Audrey, additional, Valkov, Mikhail, additional, Johnson, Christopher J, additional, Estève, Jacques, additional, Ogunbiyi, Olufemi J, additional, Azevedo e Silva, Gulnar, additional, Chen, Wan-Qing, additional, Eser, Sultan, additional, Engholm, Gerda, additional, Stiller, Charles A, additional, Monnereau, Alain, additional, Woods, Ryan R, additional, Visser, Otto, additional, Lim, Gek Hsiang, additional, Aitken, Joanne, additional, Weir, Hannah K, additional, Coleman, Michel P, additional, Bouzbid, S, additional, Hamdi-Chérif, M, additional, Zaidi, Z, additional, Meguenni, K, additional, Regagba, D, additional, Bayo, S, additional, Cheick Bougadari, T, additional, Manraj, S S, additional, Bendahhou, K, additional, Fabowale, A, additional, Bradshaw, D, additional, Somdyala, N I M, additional, Kumcher, I, additional, Moreno, F, additional, Calabrano, G H, additional, Espinola, S B, additional, Carballo Quintero, B, additional, Fita, R, additional, Diumenjo, M C, additional, Laspada, W D, additional, Ibañez, S G, additional, Lima, C A, additional, De Souza, P C F, additional, Del Pino, K, additional, Laporte, C, additional, Curado, M P, additional, de Oliveira, J C, additional, Veneziano, C L A, additional, Veneziano, D B, additional, Latorre, M R D O, additional, Tanaka, L F, additional, Rebelo, M S, additional, Santos, M O, additional, Galaz, J C, additional, Aparicio Aravena, M, additional, Sanhueza Monsalve, J, additional, Herrmann, D A, additional, Vargas, S, additional, Herrera, V M, additional, Uribe, C J, additional, Bravo, L E, additional, Garcia, L S, additional, Arias-Ortiz, N E, additional, Morantes, D, additional, Jurado, D M, additional, Yépez Chamorro, M C, additional, Delgado, S, additional, Ramirez, M, additional, Galán Alvarez, Y H, additional, Torres, P, additional, Martínez-Reyes, F, additional, Jaramillo, L, additional, Quinto, R, additional, Castillo, J, additional, Mendoza, M, additional, Cueva, P, additional, Yépez, J G, additional, Bhakkan, B, additional, Deloumeaux, J, additional, Joachim, C, additional, Macni, J, additional, Carrillo, R, additional, Shalkow Klincovstein, J, additional, Rivera Gomez, R, additional, Poquioma, E, additional, Tortolero-Luna, G, additional, Zavala, D, additional, Alonso, R, additional, Barrios, E, additional, Eckstrand, A, additional, Nikiforuk, C, additional, Noonan, G, additional, Turner, D, additional, Kumar, E, additional, Zhang, B, additional, McCrate, F R, additional, Ryan, S, additional, MacIntyre, M, additional, Saint-Jacques, N, additional, Nishri, D E, additional, McClure, C A, additional, Vriends, K A, additional, Kozie, S, additional, Stuart-Panko, H, additional, Freeman, T, additional, George, J T, additional, Brockhouse, J T, additional, O'Brien, D K, additional, Holt, A, additional, Almon, L, additional, Kwong, S, additional, Morris, C, additional, Rycroft, R, additional, Mueller, L, additional, Phillips, C E, additional, Brown, H, additional, Cromartie, B, additional, Schwartz, A G, additional, Vigneau, F, additional, Levin, G M, additional, Wohler, B, additional, Bayakly, R, additional, Ward, K C, additional, Gomez, S L, additional, McKinley, M, additional, Cress, R, additional, Green, M D, additional, Miyagi, K, additional, Ruppert, L P, additional, Lynch, C F, additional, Huang, B, additional, Tucker, T C, additional, Deapen, D, additional, Liu, L, additional, Hsieh, M C, additional, Wu, X C, additional, Schwenn, M, additional, Gershman, S T, additional, Knowlton, R C, additional, Alverson, G, additional, Copeland, G E, additional, Bushhouse, S, additional, Rogers, D B, additional, Jackson-Thompson, J, additional, Lemons, D, additional, Zimmerman, H J, additional, Hood, M, additional, Roberts-Johnson, J, additional, Rees, J R, additional, Riddle, B, additional, Pawlish, K S, additional, Stroup, A, additional, Key, C, additional, Wiggins, C, additional, Kahn, A R, additional, Schymura, M J, additional, Radhakrishnan, S, additional, Rao, C, additional, Giljahn, L K, additional, Slocumb, R M, additional, Espinoza, R E, additional, Khan, F, additional, Aird, K G, additional, Beran, T, additional, Rubertone, J J, additional, Slack, S J, additional, Garcia, L, additional, Rousseau, D L, additional, Janes, T A, additional, Schwartz, S M, additional, Bolick, S W, additional, Hurley, D M, additional, Whiteside, M A, additional, Miller-Gianturco, P, additional, Williams, M A, additional, Herget, K, additional, Sweeney, C, additional, Johnson, A T, additional, Keitheri Cheteri, M B, additional, Migliore Santiago, P, additional, Blankenship, S E, additional, Farley, S, additional, Borchers, R, additional, Malicki, R, additional, Espinoza, J R, additional, Grandpre, J, additional, Wilson, R, additional, Edwards, B K, additional, Mariotto, A, additional, Lei, Y, additional, Wang, N, additional, Chen, J S, additional, Zhou, Y, additional, He, Y T, additional, Song, G H, additional, Gu, X P, additional, Mei, D, additional, Mu, H J, additional, Ge, H M, additional, Wu, T H, additional, Li, Y Y, additional, Zhao, D L, additional, Jin, F, additional, Zhang, J H, additional, Zhu, F D, additional, Junhua, Q, additional, Yang, Y L, additional, Jiang, C X, additional, Biao, W, additional, Wang, J, additional, Li, Q L, additional, Yi, H, additional, Zhou, X, additional, Dong, J, additional, Li, W, additional, Fu, F X, additional, Liu, S Z, additional, Chen, J G, additional, Zhu, J, additional, Li, Y H, additional, Lu, Y Q, additional, Fan, M, additional, Huang, S Q, additional, Guo, G P, additional, Zhaolai, H, additional, Wei, K, additional, Zeng, H, additional, Demetriou, A V, additional, Mang, W K, additional, Ngan, K C, additional, Kataki, A C, additional, Krishnatreya, M, additional, Jayalekshmi, P A, additional, Sebastian, P, additional, Nandakumar, A, additional, Malekzadeh, R, additional, Roshandel, G, additional, Keinan-Boker, L, additional, Silverman, B G, additional, Ito, H, additional, Nakagawa, H, additional, Sato, M, additional, Tobori, F, additional, Nakata, I, additional, Teramoto, N, additional, Hattori, M, additional, Kaizaki, Y, additional, Moki, F, additional, Sugiyama, H, additional, Utada, M, additional, Nishimura, M, additional, Yoshida, K, additional, Kurosawa, K, additional, Nemoto, Y, additional, Narimatsu, H, additional, Sakaguchi, M, additional, Kanemura, S, additional, Naito, M, additional, Narisawa, R, additional, Miyashiro, I, additional, Nakata, K, additional, Sato, S, additional, Yoshii, M, additional, Oki, I, additional, Fukushima, N, additional, Shibata, A, additional, Iwasa, K, additional, Ono, C, additional, Nimri, O, additional, Jung, K W, additional, Won, Y J, additional, Alawadhi, E, additional, Elbasmi, A, additional, Ab Manan, A, additional, Adam, F, additional, Sanjaajmats, E, additional, Tudev, U, additional, Ochir, C, additional, Al Khater, A M, additional, El Mistiri, M M, additional, Teo, Y Y, additional, Chiang, C J, additional, Lee, W C, additional, Buasom, R, additional, Sangrajrang, S, additional, Kamsa-ard, S, additional, Wiangnon, S, additional, Daoprasert, K, additional, Pongnikorn, D, additional, Leklob, A, additional, Sangkitipaiboon, S, additional, Geater, S L, additional, Sriplung, H, additional, Ceylan, O, additional, Kög, I, additional, Dirican, O, additional, Köse, T, additional, Gurbuz, T, additional, Karaşahin, F E, additional, Turhan, D, additional, Aktaş, U, additional, Halat, Y, additional, Yakut, C I, additional, Altinisik, M, additional, Cavusoglu, Y, additional, Türkköylü, A, additional, Üçüncü, N, additional, Hackl, M, additional, Zborovskaya, A A, additional, Aleinikova, O V, additional, Henau, K, additional, Van Eycken, L, additional, Valerianova, Z, additional, Yordanova, M R, additional, Šekerija, M, additional, Dušek, L, additional, Zvolský, M, additional, Storm, H, additional, Innos, K, additional, Mägi, M, additional, Malila, N, additional, Seppä, K, additional, Jégu, J, additional, Velten, M, additional, Cornet, E, additional, Troussard, X, additional, Bouvier, A M, additional, Guizard, A V, additional, Bouvier, V, additional, Launoy, G, additional, Arveux, P, additional, Maynadié, M, additional, Mounier, M, additional, Woronoff, A S, additional, Daoulas, M, additional, Robaszkiewicz, M, additional, Clavel, J, additional, Goujon, S, additional, Lacour, B, additional, Baldi, I, additional, Pouchieu, C, additional, Amadeo, B, additional, Coureau, G, additional, Orazio, S, additional, Preux, P M, additional, Rharbaoui, F, additional, Marrer, E, additional, Trétarre, B, additional, Colonna, M, additional, Delafosse, P, additional, Ligier, K, additional, Plouvier, S, additional, Cowppli-Bony, A, additional, Molinié, F, additional, Bara, S, additional, Ganry, O, additional, Lapôtre-Ledoux, B, additional, Grosclaude, P, additional, Bossard, N, additional, Uhry, Z, additional, Bray, F, additional, Piñeros, M, additional, Stabenow, R, additional, Wilsdorf-Köhler, H, additional, Eberle, A, additional, Luttmann, S, additional, Löhden, I, additional, Nennecke, A L, additional, Kieschke, J, additional, Sirri, E, additional, Emrich, K, additional, Zeissig, S R, additional, Holleczek, B, additional, Eisemann, N, additional, Katalinic, A, additional, Asquez, R A, additional, Kumar, V, additional, Petridou, E, additional, Ólafsdóttir, E J, additional, Tryggvadóttir, L, additional, Clough-Gorr, K, additional, Walsh, P M, additional, Sundseth, H, additional, Mazzoleni, G, additional, Vittadello, F, additional, Coviello, E, additional, Cuccaro, F, additional, Galasso, R, additional, Sampietro, G, additional, Giacomin, A, additional, Magoni, M, additional, Ardizzone, A, additional, D'Argenzio, A, additional, Castaing, M, additional, Grosso, G, additional, Lavecchia, A M, additional, Sutera Sardo, A, additional, Gola, G, additional, Gatti, L, additional, Ricci, P, additional, Ferretti, S, additional, Serraino, D, additional, Zucchetto, A, additional, Celesia, M V, additional, Filiberti, R A, additional, Pannozzo, F, additional, Melcarne, A, additional, Quarta, F, additional, Russo, A G, additional, Carrozzi, G, additional, Cirilli, C, additional, Cavalieri d'Oro, L, additional, Rognoni, M, additional, Fusco, M, additional, Vitale, M F, additional, Usala, M, additional, Cusimano, R, additional, Mazzucco, W, additional, Michiara, M, additional, Sgargi, P, additional, Boschetti, L, additional, Borciani, E, additional, Seghini, P, additional, Maule, M M, additional, Merletti, F, additional, Tumino, R, additional, Mancuso, P, additional, Vicentini, M, additional, Cassetti, T, additional, Sassatelli, R, additional, Falcini, F, additional, Giorgetti, S, additional, Caiazzo, A L, additional, Cavallo, R, additional, Cesaraccio, R, additional, Pirino, D R, additional, Contrino, M L, additional, Tisano, F, additional, Fanetti, A C, additional, Maspero, S, additional, Carone, S, additional, Mincuzzi, A, additional, Candela, G, additional, Scuderi, T, additional, Gentilini, M A, additional, Piffer, S, additional, Rosso, S, additional, Barchielli, A, additional, Caldarella, A, additional, Bianconi, F, additional, Stracci, F, additional, Contiero, P, additional, Tagliabue, G, additional, Rugge, M, additional, Zorzi, M, additional, Beggiato, S, additional, Brustolin, A, additional, Berrino, F, additional, Gatta, G, additional, Sant, M, additional, Buzzoni, C, additional, Mangone, L, additional, Capocaccia, R, additional, De Angelis, R, additional, Zanetti, R, additional, Maurina, A, additional, Pildava, S, additional, Lipunova, N, additional, Vincerževskiené, I, additional, Agius, D, additional, Calleja, N, additional, Siesling, S, additional, Larønningen, S, additional, Møller, B, additional, Dyzmann-Sroka, A, additional, Trojanowski, M, additional, Góźdź, S, additional, Mężyk, R, additional, Mierzwa, T, additional, Molong, L, additional, Rachtan, J, additional, Szewczyk, S, additional, Błaszczyk, J, additional, Kępska, K, additional, Kościańska, B, additional, Tarocińska, K, additional, Zwierko, M, additional, Drosik, K, additional, Maksimowicz, K M, additional, Purwin-Porowska, E, additional, Reca, E, additional, Wójcik-Tomaszewska, J, additional, Tukiendorf, A, additional, Grądalska-Lampart, M, additional, Radziszewska, A U, additional, Gos, A, additional, Talerczyk, M, additional, Wyborska, M, additional, Didkowska, J A, additional, Wojciechowska, U, additional, Bielska-Lasota, M, additional, Forjaz de Lacerda, G, additional, Rego, R A, additional, Bastos, J, additional, Silva, M A, additional, Antunes, L, additional, Laranja Pontes, J, additional, Mayer-da-Silva, A, additional, Miranda, A, additional, Blaga, L M, additional, Coza, D, additional, Gusenkova, L, additional, Lazarevich, O, additional, Prudnikova, O, additional, Vjushkov, D M, additional, Egorova, A G, additional, Orlov, A E, additional, Kudyakov, L A, additional, Pikalova, L V, additional, Adamcik, J, additional, Safaei Diba, C, additional, Primic-Žakelj, M, additional, Zadnik, V, additional, Larrañaga, N, additional, Lopez de Munain, A, additional, Herrera, A A, additional, Redondas, R, additional, Marcos-Gragera, R, additional, Vilardell Gil, M L, additional, Molina, E, additional, Sánchez Perez, M J, additional, Franch Sureda, P, additional, Ramos Montserrat, M, additional, Chirlaque, M D, additional, Navarro, C, additional, Ardanaz, E E, additional, Guevara, M M, additional, Fernández-Delgado, R, additional, Peris-Bonet, R, additional, Carulla, M, additional, Galceran, J, additional, Alberich, C, additional, Vicente-Raneda, M, additional, Khan, S, additional, Pettersson, D, additional, Dickman, P, additional, Avelina, I, additional, Staehelin, K, additional, Camey, B, additional, Bouchardy, C, additional, Schaffar, R, additional, Frick, H, additional, Herrmann, C, additional, Bulliard, J L, additional, Maspoli-Conconi, M, additional, Kuehni, C E, additional, Redmond, S M, additional, Bordoni, A, additional, Ortelli, L, additional, Chiolero, A, additional, Konzelmann, I, additional, Matthes, K L, additional, Rohrmann, S, additional, Broggio, J, additional, Rashbass, J, additional, Fitzpatrick, D, additional, Gavin, A, additional, Clark, D I, additional, Deas, A J, additional, Huws, D W, additional, White, C, additional, Montel, L, additional, Rachet, B, additional, Turculet, A D, additional, Stephens, R, additional, Chalker, E, additional, Phung, H, additional, Walton, R, additional, You, H, additional, Guthridge, S, additional, Johnson, F, additional, Gordon, P, additional, D'Onise, K, additional, Priest, K, additional, Stokes, B C, additional, Venn, A, additional, Farrugia, H, additional, Thursfield, V, additional, Dowling, J, additional, Currow, D, additional, Hendrix, J, additional, and Lewis, C, additional

Published
2018
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12. Identification and replication of the interplay of four genetic high-risk variants for urinary bladder cancer

Author

Selinski, S., Blaszkewicz, M., Ickstadt, K., Gerullis, H., Otto, T., Roth, E., Volkert, F., Ovsiannikov, D., Moormann, O., Banfi, G., Nyirady, P., Vermeulen, S.H., Garcia-Closas, M., Figueroa, J.D., Johnson, A., Karagas, M.R., Kogevinas, M., Malats, N., Schwenn, M., Silverman, D.T., Koutros, S., Rothman, N., Kiemeney, L.A., Hengstler, J.G., Golka, K., Selinski, S., Blaszkewicz, M., Ickstadt, K., Gerullis, H., Otto, T., Roth, E., Volkert, F., Ovsiannikov, D., Moormann, O., Banfi, G., Nyirady, P., Vermeulen, S.H., Garcia-Closas, M., Figueroa, J.D., Johnson, A., Karagas, M.R., Kogevinas, M., Malats, N., Schwenn, M., Silverman, D.T., Koutros, S., Rothman, N., Kiemeney, L.A., Hengstler, J.G., and Golka, K.

Abstract

Contains fulltext : 181627.pdf (Publisher’s version ) (Open Access), Little is known whether genetic variants identified in genome-wide association studies interact to increase bladder cancer risk. Recently, we identified two- and three-variant combinations associated with a particular increase of bladder cancer risk in a urinary bladder cancer case-control series (Leibniz Research Centre for Working Environment and Human Factors at TU Dortmund (IfADo), 1501 cases, 1565 controls). In an independent case-control series (Nijmegen Bladder Cancer Study, NBCS, 1468 cases, 1720 controls) we confirmed these two- and three-variant combinations. Pooled analysis of the two studies as discovery group (IfADo-NBCS) resulted in sufficient statistical power to test up to four-variant combinations by a logistic regression approach. The New England and Spanish Bladder Cancer Studies (2080 cases and 2167 controls) were used as a replication series. Twelve previously identified risk variants were considered. The strongest four-variant combination was obtained in never smokers. The combination of rs1014971[AA] near apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A (APOBEC3A) and chromobox homolog 6 (CBX6), solute carrier family 1s4 (urea transporter), member 1 (Kidd blood group) (SLC14A1) exon single nucleotide polymorphism (SNP) rs1058396[AG, GG], UDP glucuronosyltransferase 1 family, polypeptide A complex locus (UGT1A) intron SNP rs11892031[AA] and rs8102137[CC, CT] near cyclin E1 (CCNE1) resulted in an unadjusted odds ratio (OR) of 2.59 (95% CI = 1.93-3.47; P = 1.87 x 10-10), while the individual variant ORs ranged only between 1.11 and 1.30. The combination replicated in the New England and Spanish Bladder Cancer Studies (ORunadjusted = 1.60, 95% CI = 1.10-2.33; P = 0.013). The four-variant combination is relatively frequent, with 25% in never smoking cases and 11% in never smoking controls (total study group: 19% cases, 14% controls). In conclusion, we show that four high-risk variants can statistically interact to confer increase

Published
2017

13. International incidence of childhood cancer, 2001-10: a population-based registry study.

Author

IICC-3 contributors, Bouzbid, S., Hamdi-Cherif, M., Hablas, A., Chirpaz, E., Buziba, N., Chesumbai, G.C., Manraj, S.S., Reynders, D., Wabinga, H.R., Chokunonga, E., Moreno, F., Lima, C.A., Asturian Laporte, C., de Oliveira, J.C., de Aquino, J.P., Gallagher, S.V., Uribe, C.J., Bravo, L.E., Yepez Chamorro, M.C., Torres Alvarado, G., Galán Alvarez, Y.H., Martinez Reyes, F.C., Castillo Calvas, J.C., Mendoza Alava, M., Cueva Ayala, P., Hanchard, B., Fajardo-Gutiérrez, A., Zavala Zegarra, D.E., Barrios, E., Nikiforuk, C., Woods, R., Turner, D., MacIntyre, M., Corriveau, A., Navaneelan, T., Bertrand, C., Stuart-Panko, H., Wilson, R.J., Kosary, C., Shen, X., Brockhouse, J., Yee, G.A., Mitchell, T.C., Snipes, K., West, D., Rao, C., Bolick, S., Rycroft, R.K., Mueller, L., Zheng, Y., Dosch, K., Brown, H., Vargas, A., Levin, G.M., Bayakly, R., Johnson, C., Shen, T., Ruppert, L., Lynch, C.F., Lai, S.M., Tucker, T.C., Wu, X.C., Schwenn, M., Stern, K., Gershman, S., Copeland, G., Bushhouse, S., Rogers, D.B., Jackson Thompson, J., Lemons, D., Frederick, S., Harris, J.A., Riddle, B., Stroup, A., Wiggins, C., Schymura, M.J., Giljahn, L.K., Sheikh, A., Schubert, S., Aldinger, W., Fulton, J.P., Whiteside, M., Nogueira, L., Sweeney, C., Johnson, A., Martin, J., Farley, S., Harrelson, D., Malicki, R., Espinoza, J.R., Hernandez, B.Y., Abulfateh, N., Wang, N., Ngan, R., Lingegowda, K.B., Swaminathan, R., Koyande, S.S., Silverman, B., Ozasa, K., Kanemura, S., Soda, M., Miyashiro, I., Shibata, A., Nimri, O., Won, Y.J., Kim, C.H., Hong, N.S., Nam, H.S., Kweon, S., Kim, W.C., Huh, J.S., Jung, K.W., Yoo, C.I., Elbasmy, A., Laudico, A.V., Lumague, M.R., AlMutlag, H., Buasom, R., Srisukho, S., Tanabodee, J., Wiangnon, S., Pongnikorn, D., Sriplung, H., Dirican, O., Eser, S., Le Hoang, M., Hackl, M., Zborovskaya, A., Dimitrova, N., Valerianova, Z., Sekerija, M., Pavlou, P., Dušek, M., Mägi, M., Clavel, J., Lacour, B., Guizard, A.V., Bouvier, V., Troussard, X., Woronoff, A.S., Tretarre, B., Colonna, M., Molinié, F., Bara, S., Velten, M., Marrer, E., Ganry, O., Grosclaude, P., Kaatsch, P., Zeissig, S.R., Holleczek, B., Katalinic, A., Jakab, Z., Birgisson, H., Walsh, P.M., Mangone, L., Merletti, F., Magoni, M., Ferretti, S., Serraino, D., Spagnoli, G., Fusco, M., Michiara, M., Tumino, R., Falcini, F., Sensi, F., Tisano, F., Piffer, S., Stracci, F., Tagliabue, G., Smailyte, G., Agius, D., Visser, O., Ursin, G., Didkowska, J., Trojanowski, M., Wojciechowska, U., Forjaz de Lacerda, G., Silva, M.A., Laranja Pontes, J., da Costa Miranda, A., Kaiserova, E., Primic Žakelj, M., Peris-Bonet, R., Vicente Raneda, M.L., Almar Marqués, E., Quirós Garcia, J.R., Ramos Monserrat, M., Errezola Saizar, M., Alemán Herrera, A., Díaz García, J.M., Marcos-Gragera, R., Sanchez-Perez, M.J., Ardanaz Aicua, E., Galceran, J., Klint, A., Kuehni, C.E., Bouchardy, C., Levi, F., Bordoni, A., Konzelmann, I., Rohrmann, S., Stiller, C.A., Gavin, A.T., Brewster, D.H., Phung, H., Rushton, S., Guthridge, S., Aitken, J., D'Onise, K., Venn, A., Farrugian, H., Threlfall, T.J., Laumond, S., Yen Kai Sun, L., Hendrix, J., Ballantine, K., Colombet, M., Dolya, A., Masuyer, E., Steliarova-Foucher, E., Ries, LAG, Bray, F., Hesseling, P., Shin, H.Y., IICC-3 contributors, Bouzbid, S., Hamdi-Cherif, M., Hablas, A., Chirpaz, E., Buziba, N., Chesumbai, G.C., Manraj, S.S., Reynders, D., Wabinga, H.R., Chokunonga, E., Moreno, F., Lima, C.A., Asturian Laporte, C., de Oliveira, J.C., de Aquino, J.P., Gallagher, S.V., Uribe, C.J., Bravo, L.E., Yepez Chamorro, M.C., Torres Alvarado, G., Galán Alvarez, Y.H., Martinez Reyes, F.C., Castillo Calvas, J.C., Mendoza Alava, M., Cueva Ayala, P., Hanchard, B., Fajardo-Gutiérrez, A., Zavala Zegarra, D.E., Barrios, E., Nikiforuk, C., Woods, R., Turner, D., MacIntyre, M., Corriveau, A., Navaneelan, T., Bertrand, C., Stuart-Panko, H., Wilson, R.J., Kosary, C., Shen, X., Brockhouse, J., Yee, G.A., Mitchell, T.C., Snipes, K., West, D., Rao, C., Bolick, S., Rycroft, R.K., Mueller, L., Zheng, Y., Dosch, K., Brown, H., Vargas, A., Levin, G.M., Bayakly, R., Johnson, C., Shen, T., Ruppert, L., Lynch, C.F., Lai, S.M., Tucker, T.C., Wu, X.C., Schwenn, M., Stern, K., Gershman, S., Copeland, G., Bushhouse, S., Rogers, D.B., Jackson Thompson, J., Lemons, D., Frederick, S., Harris, J.A., Riddle, B., Stroup, A., Wiggins, C., Schymura, M.J., Giljahn, L.K., Sheikh, A., Schubert, S., Aldinger, W., Fulton, J.P., Whiteside, M., Nogueira, L., Sweeney, C., Johnson, A., Martin, J., Farley, S., Harrelson, D., Malicki, R., Espinoza, J.R., Hernandez, B.Y., Abulfateh, N., Wang, N., Ngan, R., Lingegowda, K.B., Swaminathan, R., Koyande, S.S., Silverman, B., Ozasa, K., Kanemura, S., Soda, M., Miyashiro, I., Shibata, A., Nimri, O., Won, Y.J., Kim, C.H., Hong, N.S., Nam, H.S., Kweon, S., Kim, W.C., Huh, J.S., Jung, K.W., Yoo, C.I., Elbasmy, A., Laudico, A.V., Lumague, M.R., AlMutlag, H., Buasom, R., Srisukho, S., Tanabodee, J., Wiangnon, S., Pongnikorn, D., Sriplung, H., Dirican, O., Eser, S., Le Hoang, M., Hackl, M., Zborovskaya, A., Dimitrova, N., Valerianova, Z., Sekerija, M., Pavlou, P., Dušek, M., Mägi, M., Clavel, J., Lacour, B., Guizard, A.V., Bouvier, V., Troussard, X., Woronoff, A.S., Tretarre, B., Colonna, M., Molinié, F., Bara, S., Velten, M., Marrer, E., Ganry, O., Grosclaude, P., Kaatsch, P., Zeissig, S.R., Holleczek, B., Katalinic, A., Jakab, Z., Birgisson, H., Walsh, P.M., Mangone, L., Merletti, F., Magoni, M., Ferretti, S., Serraino, D., Spagnoli, G., Fusco, M., Michiara, M., Tumino, R., Falcini, F., Sensi, F., Tisano, F., Piffer, S., Stracci, F., Tagliabue, G., Smailyte, G., Agius, D., Visser, O., Ursin, G., Didkowska, J., Trojanowski, M., Wojciechowska, U., Forjaz de Lacerda, G., Silva, M.A., Laranja Pontes, J., da Costa Miranda, A., Kaiserova, E., Primic Žakelj, M., Peris-Bonet, R., Vicente Raneda, M.L., Almar Marqués, E., Quirós Garcia, J.R., Ramos Monserrat, M., Errezola Saizar, M., Alemán Herrera, A., Díaz García, J.M., Marcos-Gragera, R., Sanchez-Perez, M.J., Ardanaz Aicua, E., Galceran, J., Klint, A., Kuehni, C.E., Bouchardy, C., Levi, F., Bordoni, A., Konzelmann, I., Rohrmann, S., Stiller, C.A., Gavin, A.T., Brewster, D.H., Phung, H., Rushton, S., Guthridge, S., Aitken, J., D'Onise, K., Venn, A., Farrugian, H., Threlfall, T.J., Laumond, S., Yen Kai Sun, L., Hendrix, J., Ballantine, K., Colombet, M., Dolya, A., Masuyer, E., Steliarova-Foucher, E., Ries, LAG, Bray, F., Hesseling, P., and Shin, H.Y.

Abstract

Cancer is a major cause of death in children worldwide, and the recorded incidence tends to increase with time. Internationally comparable data on childhood cancer incidence in the past two decades are scarce. This study aimed to provide internationally comparable local data on the incidence of childhood cancer to promote research of causes and implementation of childhood cancer control. This population-based registry study, devised by the International Agency for Research on Cancer in collaboration with the International Association of Cancer Registries, collected data on all malignancies and non-malignant neoplasms of the CNS diagnosed before age 20 years in populations covered by high-quality cancer registries with complete data for 2001-10. Incidence rates per million person-years for the 0-14 years and 0-19 years age groups were age-adjusted using the world standard population to provide age-standardised incidence rates (WSRs), using the age-specific incidence rates (ASR) for individual age groups (0-4 years, 5-9 years, 10-14 years, and 15-19 years). All rates were reported for 19 geographical areas or ethnicities by sex, age group, and cancer type. The regional WSRs for children aged 0-14 years were compared with comparable data obtained in the 1980s. Of 532 invited cancer registries, 153 registries from 62 countries, departments, and territories met quality standards, and contributed data for the entire decade of 2001-10. 385 509 incident cases in children aged 0-19 years occurring in 2·64 billion person-years were included. The overall WSR was 140·6 per million person-years in children aged 0-14 years (based on 284 649 cases), and the most common cancers were leukaemia (WSR 46·4), followed by CNS tumours (WSR 28·2), and lymphomas (WSR 15·2). In children aged 15-19 years (based on 100 860 cases), the ASR was 185·3 per million person-years, the most common being lymphomas (ASR 41·8) and the group of epithelial tumours and melanoma (ASR 39·5). Incidence varied

Published
2017

14. Global surveillance of trends in cancer survival 2000–14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries

Author

Allemani, Claudia;Matsuda, Tomohiro;Di Carlo, Veronica;Harewood, Rhea;Matz, Melissa;Nikšić, Maja;Bonaventure, Audrey;Valkov, Mikhail;Johnson, Christopher J;Estève, Jacques;Ogunbiyi, Olufemi J;Azevedo e Silva, Gulnar;Chen, Wan-Qing;Eser, Sultan;Engholm, Gerda;Stiller, Charles A;Monnereau, Alain;Woods, Ryan R;Visser, Otto;Lim, Gek Hsiang;Aitken, Joanne;Weir, Hannah K;Coleman, Michel P;Bouzbid, S;Hamdi-Chérif, M;Zaidi, Z;Meguenni, K;Regagba, D;Bayo, S;Cheick Bougadari, T;Manraj, S S;Bendahhou, K;Fabowale, A;Bradshaw, D;Somdyala, N I M;Kumcher, I;Moreno, F;Calabrano, G H;Espinola, S B;Carballo Quintero, B;Fita, R;Diumenjo, M C;Laspada, W D;Ibañez, S G;Lima, C A;De Souza, P C F;Del Pino, K;Laporte, C;Curado, M P;de Oliveira, J C;Veneziano, C L A;Veneziano, D B;Latorre, M R D O;Tanaka, L F;Rebelo, M S;Santos, M O;Galaz, J C;Aparicio Aravena, M;Sanhueza Monsalve, J;Herrmann, D A;Vargas, S;Herrera, V M;Uribe, C J;Bravo, L E;Garcia, L S;Arias-Ortiz, N E;Morantes, D;Jurado, D M;Yépez Chamorro, M C;Delgado, S;Ramirez, M;Galán Alvarez, Y H;Torres, P;Martínez-Reyes, F;Jaramillo, L;Quinto, R;Castillo, J;Mendoza, M;Cueva, P;Yépez, J G;Bhakkan, B;Deloumeaux, J;Joachim, C;Macni, J;Carrillo, R;Shalkow Klincovstein, J;Rivera Gomez, R;Poquioma, E;Tortolero-Luna, G;Zavala, D;Alonso, R;Barrios, E;Eckstrand, A;Nikiforuk, C;Noonan, G;Turner, D;Kumar, E;Zhang, B;McCrate, F R;Ryan, S;MacIntyre, M;Saint-Jacques, N;Nishri, D E;McClure, C A;Vriends, K A;Kozie, S;Stuart-Panko, H;Freeman, T;George, J T;Brockhouse, J T;O'Brien, D K;Holt, A;Almon, L;Kwong, S;Morris, C;Rycroft, R;Mueller, L;Phillips, C E;Brown, H;Cromartie, B;Schwartz, A G;Vigneau, F;Levin, G M;Wohler, B;Bayakly, R;Ward, K C;Gomez, S L;McKinley, M;Cress, R;Green, M D;Miyagi, K;Ruppert, L P;Lynch, C F;Huang, B;Tucker, T C;Deapen, D;Liu, L;Hsieh, M C;Wu, X C;Schwenn, M;Gershman, S T;Knowlton, R C;Alverson, G;Copeland, G E;Bushhouse, S;Rogers, D B;Jackson-Thompson, J;Lemons, D;Zimmerman, H J;Hood, M;Roberts-Johnson, J;Rees, J R;Riddle and Allemani, Claudia;Matsuda, Tomohiro;Di Carlo, Veronica;Harewood, Rhea;Matz, Melissa;Nikšić, Maja;Bonaventure, Audrey;Valkov, Mikhail;Johnson, Christopher J;Estève, Jacques;Ogunbiyi, Olufemi J;Azevedo e Silva, Gulnar;Chen, Wan-Qing;Eser, Sultan;Engholm, Gerda;Stiller, Charles A;Monnereau, Alain;Woods, Ryan R;Visser, Otto;Lim, Gek Hsiang;Aitken, Joanne;Weir, Hannah K;Coleman, Michel P;Bouzbid, S;Hamdi-Chérif, M;Zaidi, Z;Meguenni, K;Regagba, D;Bayo, S;Cheick Bougadari, T;Manraj, S S;Bendahhou, K;Fabowale, A;Bradshaw, D;Somdyala, N I M;Kumcher, I;Moreno, F;Calabrano, G H;Espinola, S B;Carballo Quintero, B;Fita, R;Diumenjo, M C;Laspada, W D;Ibañez, S G;Lima, C A;De Souza, P C F;Del Pino, K;Laporte, C;Curado, M P;de Oliveira, J C;Veneziano, C L A;Veneziano, D B;Latorre, M R D O;Tanaka, L F;Rebelo, M S;Santos, M O;Galaz, J C;Aparicio Aravena, M;Sanhueza Monsalve, J;Herrmann, D A;Vargas, S;Herrera, V M;Uribe, C J;Bravo, L E;Garcia, L S;Arias-Ortiz, N E;Morantes, D;Jurado, D M;Yépez Chamorro, M C;Delgado, S;Ramirez, M;Galán Alvarez, Y H;Torres, P;Martínez-Reyes, F;Jaramillo, L;Quinto, R;Castillo, J;Mendoza, M;Cueva, P;Yépez, J G;Bhakkan, B;Deloumeaux, J;Joachim, C;Macni, J;Carrillo, R;Shalkow Klincovstein, J;Rivera Gomez, R;Poquioma, E;Tortolero-Luna, G;Zavala, D;Alonso, R;Barrios, E;Eckstrand, A;Nikiforuk, C;Noonan, G;Turner, D;Kumar, E;Zhang, B;McCrate, F R;Ryan, S;MacIntyre, M;Saint-Jacques, N;Nishri, D E;McClure, C A;Vriends, K A;Kozie, S;Stuart-Panko, H;Freeman, T;George, J T;Brockhouse, J T;O'Brien, D K;Holt, A;Almon, L;Kwong, S;Morris, C;Rycroft, R;Mueller, L;Phillips, C E;Brown, H;Cromartie, B;Schwartz, A G;Vigneau, F;Levin, G M;Wohler, B;Bayakly, R;Ward, K C;Gomez, S L;McKinley, M;Cress, R;Green, M D;Miyagi, K;Ruppert, L P;Lynch, C F;Huang, B;Tucker, T C;Deapen, D;Liu, L;Hsieh, M C;Wu, X C;Schwenn, M;Gershman, S T;Knowlton, R C;Alverson, G;Copeland, G E;Bushhouse, S;Rogers, D B;Jackson-Thompson, J;Lemons, D;Zimmerman, H J;Hood, M;Roberts-Johnson, J;Rees, J R;Riddle

Published
2017

15. Combining Decision Rules from Classification Tree Models and Expert Assessment to Estimate Occupational Exposure to Diesel Exhaust for a Case-Control Study

Author

Friesen, M.C., Wheeler, D.C., Vermeulen, R., Locke, S.J., Zaebst, D.D., Koutros, S., Pronk, A., Colt, J.S., Baris, D., Karagas, M.R., Malats, N., Schwenn, M., Johnson, A., Armenti, K.R., Rothman, N., Stewart, P.A., Kogevinas, M., and Silverman, D.T.

Subjects
Exposure assessment methodology, RAPID - Risk Analysis for Products in Development, Biomedical Innovation, Case-control, Occupational exposure, Statistical learning, Life, ELSS - Earth, Life and Social Sciences, Biology, Biomedical engineering, Diesel exhausts, Healthy Living, Industrial hygiene, Probability
Abstract

Objectives: To efficiently and reproducibly assess occupational diesel exhaust exposure in a Spanish case-control study, we examined the utility of applying decision rules that had been extracted from expert estimates and questionnaire response patterns using classification tree (CT) models from a similar US study. Methods: First, previously extracted CT decision rules were used to obtain initial ordinal (0-3) estimates of the probability, intensity, and frequency of occupational exposure to diesel exhaust for the 10 182 jobs reported in a Spanish case-control study of bladder cancer. Second, two experts reviewed the CT estimates for 350 jobs randomly selected from strata based on each CT rule's agreement with the expert ratings in the original study [agreement rate, from 0 (no agreement) to 1 (perfect agreement)]. Their agreement with each other and with the CT estimates was calculated using weighted kappa (κw) and guided our choice of jobs for subsequent expert review. Third, an expert review comprised all jobs with lower confidence (low-to-moderate agreement rates or discordant assignments, n = 931) and a subset of jobs with a moderate to high CT probability rating and with moderately high agreement rates (n = 511). Logistic regression was used to examine the likelihood that an expert provided a different estimate than the CT estimate based on the CT rule agreement rates, the CT ordinal rating, and the availability of a module with diesel-related questions. Results: Agreement between estimates made by two experts and between estimates made by each of the experts and the CT estimates was very high for jobs with estimates that were determined by rules with high CT agreement rates (κw: 0.81-0.90). For jobs with estimates based on rules with lower agreement rates, moderate agreement was observed between the two experts (κw: 0.42-0.67) and poor-to-moderate agreement was observed between the experts and the CT estimates (κw: 0.09-0.57). In total, the expert review of 1442 jobs changed 156 probability estimates, 128 intensity estimates, and 614 frequency estimates. The expert was more likely to provide a different estimate when the CT rule agreement rate was

Published
2016

16. International incidence of childhood cancer, 2001–10: a population-based registry study

Author

Steliarova-Foucher, Eva, primary, Colombet, Murielle, additional, Ries, Lynn A G, additional, Moreno, Florencia, additional, Dolya, Anastasia, additional, Bray, Freddie, additional, Hesseling, Peter, additional, Shin, Hee Young, additional, Stiller, Charles A, additional, Bouzbid, S, additional, Hamdi-Cherif, M, additional, Hablas, A, additional, Chirpaz, E, additional, Buziba, N, additional, Chesumbai, GC, additional, Manraj, SS, additional, Reynders, D, additional, Wabinga, HR, additional, Chokunonga, E, additional, Moreno, F, additional, Lima, CA, additional, Asturian Laporte, C, additional, de Oliveira, JC, additional, de Aquino, JA Pontes, additional, Gallagher, SM Vargas, additional, Uribe, CJ, additional, Bravo, LE, additional, Yepez Chamorro, MC, additional, Torres Alvarado, G, additional, Galán Alvarez, YH, additional, Martinez Reyes, FC, additional, Castillo Calvas, JC, additional, Mendoza Alava, M, additional, Cueva Ayala, P, additional, Hanchard, B, additional, Fajardo-Gutiérrez, A, additional, Zavala Zegarra, DE, additional, Barrios, E, additional, Nikiforuk, C, additional, Woods, R, additional, Turner, D, additional, MacIntyre, M, additional, Corriveau, A, additional, Navaneelan, T, additional, Bertrand, C, additional, Stuart-Panko, H, additional, Wilson, RJ, additional, Kosary, C, additional, Shen, X, additional, Brockhouse, J, additional, Yee, GA, additional, Mitchell, TC, additional, Snipes, K, additional, West, D, additional, Rao, C, additional, Bolick, S, additional, Rycroft, RK, additional, Mueller, L, additional, Zheng, Y, additional, Dosch, K, additional, Brown, H, additional, Vargas, A, additional, Levin, GM, additional, Bayakly, R, additional, Johnson, C, additional, Shen, T, additional, Ruppert, L, additional, Lynch, CF, additional, Lai, SM, additional, Tucker, TC, additional, Wu, XC, additional, Schwenn, M, additional, Stern, K, additional, Gershman, S, additional, Copeland, G, additional, Bushhouse, S, additional, Rogers, DB, additional, Jackson Thompson, J, additional, Lemons, D, additional, Frederick, S, additional, Harris, JA, additional, Riddle, B, additional, Stroup, A, additional, Wiggins, C, additional, Schymura, MJ, additional, Giljahn, LK, additional, Sheikh, A, additional, Schubert, S, additional, Aldinger, W, additional, Fulton, JP, additional, Whiteside, M, additional, Nogueira, L, additional, Sweeney, C, additional, Johnson, A, additional, Martin, J, additional, Farley, S, additional, Harrelson, D, additional, Malicki, R, additional, Espinoza, JR, additional, Hernandez, BY, additional, Abulfateh, N, additional, Wang, N, additional, Ngan, RKC, additional, Lingegowda, KB, additional, Swaminathan, R, additional, Koyande, SS, additional, Silverman, B, additional, Ozasa, K, additional, Kanemura, S, additional, Soda, M, additional, Miyashiro, I, additional, Shibata, A, additional, Nimri, O, additional, Won, YJ, additional, Kim, CH, additional, Hong, NS, additional, Nam, HS, additional, Kweon, S, additional, Kim, WC, additional, Huh, JS, additional, Jung, KW, additional, Yoo, CI, additional, Elbasmy, A, additional, Laudico, AV, additional, Lumague, MR, additional, AlMutlag, H, additional, Buasom, R, additional, Srisukho, S, additional, Tanabodee, J, additional, Wiangnon, S, additional, Pongnikorn, D, additional, Sriplung, H, additional, Dirican, O, additional, Eser, S, additional, Le Hoang, M, additional, Hackl, M, additional, Zborovskaya, A, additional, Dimitrova, N, additional, Valerianova, Z, additional, Sekerija, M, additional, Pavlou, P, additional, Dušek, M, additional, Mägi, M, additional, Clavel, J, additional, Lacour, B, additional, Guizard, AV, additional, Bouvier, V, additional, Troussard, X, additional, Woronoff, AS, additional, Tretarre, B, additional, Colonna, M, additional, Molinié, F, additional, Bara, S, additional, Velten, M, additional, Marrer, E, additional, Ganry, O, additional, Grosclaude, P, additional, Kaatsch, P, additional, Zeissig, SR, additional, Holleczek, B, additional, Katalinic, A, additional, Jakab, Z, additional, Birgisson, H, additional, Walsh, PM, additional, Mangone, L, additional, Merletti, F, additional, Magoni, M, additional, Ferretti, S, additional, Serraino, D, additional, Spagnoli, G, additional, Fusco, M, additional, Michiara, M, additional, Tumino, R, additional, Falcini, F, additional, Sensi, F, additional, Tisano, F, additional, Piffer, S, additional, Stracci, F, additional, Tagliabue, G, additional, Smailyte, G, additional, Agius, D, additional, Visser, O, additional, Ursin, G, additional, Didkowska, J, additional, Trojanowski, M, additional, Wojciechowska, U, additional, Forjaz de Lacerda, G, additional, Silva, MA, additional, Laranja Pontes, J, additional, da Costa Miranda, A, additional, Kaiserova, E, additional, Primic Žakelj, M, additional, Peris-Bonet, R, additional, Vicente Raneda, ML, additional, Almar Marqués, E, additional, Quirós Garcia, JR, additional, Ramos Monserrat, M, additional, Errezola Saizar, M, additional, Alemán Herrera, A, additional, Díaz García, JM, additional, Marcos-Gragera, R, additional, Sanchez-Perez, MJ, additional, Ardanaz Aicua, E, additional, Galceran, J, additional, Klint, A, additional, Kuehni, CE, additional, Bouchardy, C, additional, Levi, F, additional, Bordoni, A, additional, Konzelmann, I, additional, Rohrmann, S, additional, Stiller, CA, additional, Gavin, AT, additional, Brewster, DH, additional, Phung, H, additional, Rushton, S, additional, Guthridge, S, additional, Aitken, J, additional, D'Onise, K, additional, Venn, A, additional, Farrugian, H, additional, Threlfall, TJ, additional, Laumond, S, additional, Yen Kai Sun, L, additional, Hendrix, J, additional, Ballantine, K, additional, Colombet, M, additional, Dolya, A, additional, Masuyer, E, additional, and Steliarova-Foucher, E, additional

Published
2017
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17. Using hierarchical cluster models to systematically identify groups of jobs with similar occupational questionnaire response patterns to assist rule-based expert exposure assessment in population-based studies

Author

Friesen, M.C., Shortreed, S.M., Wheeler, D.C., Burstyn, I., Vermeulen, R., Pronk, A., Colt, J.S., Baris, D., Karagas, M.R., Schwenn, M., Johnson, A., Armenti, K.R., Silverman, D.T., and Yu, K.

Subjects
Data reduction, Information dissemination, Work and Employment, RAPID - Risk Analysis for Products in Development, Case-control study, Surveys, Occupational exposure, Hierarchical clusters, Hierarchical systems, Cluster analysis, Life, Intraclass correlation coefficients, Exposure assessment, Probability estimate, ELSS - Earth, Life and Social Sciences, Workplace, Diesel exhausts, Hierarchical clustering methods, Healthy Living, Probability, Reduction
Abstract

Objectives: Rule-based expert exposure assessment based on questionnaire response patterns in population-based studies improves the transparency of the decisions. The number of unique response patterns, however, can be nearly equal to the number of jobs. An expert may reduce the number of patterns that need assessment using expert opinion, but each expert may identify different patterns of responses that identify an exposure scenario. Here, hierarchical clustering methods are proposed as a systematic data reduction step to reproducibly identify similar questionnaire response patterns prior to obtaining expert estimates. As a proof-of-concept, we used hierarchical clustering methods to identify groups of jobs (clusters) with similar responses to diesel exhaust-related questions and then evaluated whether the jobs within a cluster had similar (previously assessed) estimates of occupational diesel exhaust exposure. Methods: Using the New England Bladder Cancer Study as a case study, we applied hierarchical cluster models to the diesel-related variables extracted from the occupational history and job- and industry-specific questionnaires (modules). Cluster models were separately developed for two subsets: (i) 5395 jobs with ≥1 variable extracted from the occupational history indicating a potential diesel exposure scenario, but without a module with diesel-related questions; and (ii) 5929 jobs with both occupational history and module responses to diesel-relevant questions. For each subset, we varied the numbers of clusters extracted from the cluster tree developed for each model from 100 to 1000 groups of jobs. Using previously made estimates of the probability (ordinal), intensity (μg m-3 respirable elemental carbon), and frequency (hours per week) of occupational exposure to diesel exhaust, we examined the similarity of the exposure estimates for jobs within the same cluster in two ways. First, the clusters' homogeneity (defined as >75% with the same estimate) was examined compared to a dichotomized probability estimate (

Published
2015

18. Genome-wide association study identifies multiple loci associated with bladder cancer risk

Author

Figueroa, JD, Ye, Y, Siddiq, A, Garcia-Closas, M, Chatterjee, N, Prokunina-Olsson, L, Cortessis, VK, Kooperberg, C, Cussenot, O, Benhamou, S, Prescott, J, Porru, S, Dinney, CP, Malats, N, Baris, D, Purdue, M, Jacobs, EJ, Albanes, D, Wang, Z, Deng, X, Chung, CC, Tang, W, Bueno-De-Mesquita, HB, Trichopoulos, D, Ljungberg, B, Clavel-Chapelon, F, Weiderpass, E, Krogh, V, Dorronsoro, M, Travis, R, Tjonneland, A, Brenan, P, Chang-Claude, J, Riboli, E, Conti, D, Gago Dominguez, Manuela, Stern, MC, Pike, MC, Van den Berg, D, Yuan, JM, Hohensee, C, Rodabough, R, Cancel-Tassin, G, Roupret, M, Comperat, E, Chen, C, De Vivo, I, Giovannucci, E, Hunter, DJ, Kraft, P, Lindstrom, S, Carta, A, Pavanello, S, Arici, C, Mastrangelo, G, Kamat, AM, Lerner, SP, Grossman, HB, Lin, J, Gu, J, Pu, X, Hutchinson, A, Burdette, L, Wheeler, W, Kogevinas, M, Tardon, A, Serra, C, Carrato, A, Garcia-Closas, R, Lloreta, J, Schwenn, M, Karagas, MR, Johnson, A, Schned, A, Armenti, KR, Hosain, GM, Andriole, G, Grubb, R, Black, A, Diver, WR, Gapstur, SM, Weinstein, SJ, Virtamo, J, Haiman, CA, Landi, MT, Caporaso, N, Fraumeni, JF, Vineis, P, Wu, X, Silverman, DT, Chanock, S, and Rothman, N

Subjects
Risk, Genotype, Meta-Analysis as Topic, Urinary Bladder Neoplasms, Genetic Loci, Case-Control Studies, Humans, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Linkage Disequilibrium, Genome-Wide Association Study
Abstract

Candidate gene and genome-wide association studies (GWAS) have identified 11 independent susceptibility loci associated with bladder cancer risk. To discover additional risk variants, we conducted a new GWAS of 2422 bladder cancer cases and 5751 controls, followed by a meta-analysis with two independently published bladder cancer GWAS, resulting in a combined analysis of 6911 cases and 11 814 controls of European descent. TaqMan genotyping of 13 promising single nucleotide polymorphisms with P < 1 x 10(-5) was pursued in a follow-up set of 801 cases and 1307 controls. Two new loci achieved genome-wide statistical significance: rs10936599 on 3q26.2 (P = 4.53 x 10(-9)) and rs907611 on 11p15.5 (P = 4.11 x 10(-8)). Two notable loci were also identified that approached genome-wide statistical significance: rs6104690 on 20p12.2 (P = 7.13 x 10(-7)) and rs4510656 on 6p22.3 (P = 6.98 x 10(-7)); these require further studies for confirmation. In conclusion, our study has identified new susceptibility alleles for bladder cancer risk that require fine-mapping and laboratory investigation, which could further understanding into the biological underpinnings of bladder carcinogenesis.

Published
2014

19. Comparison of algorithm-based estimates of occupational diesel exhaust exposure to those of multiple independent raters in a population-based case-control study

Author

Friesen, M.C., Pronk, A., Wheeler, D.C., Chen, Y.-C., Locke, S.J., Zaebst, D.D., Schwenn, M., Johnson, A., Waddell, R., Baris, D., Colt, J.S., Silverman, D.T., Stewart, P.A., and Katki, H.A.

Subjects
exposure assessment, Life, education, Work and Employment, diesel exhaust, QS - Quality & Safety, EELS - Earth, Environmental and Life Sciences, Biology, expert judgement, Healthy Living, case-control
Abstract

Objectives: Algorithm-based exposure assessments based on patterns in questionnaire responses and professional judgment can readily apply transparent exposure decision rules to thousands of jobs quickly. However, we need to better understand how algorithms compare to a one-by-one job review by an exposure assessor. We compared algorithm-based estimates of diesel exhaust exposure to those of three independent raters within the New England Bladder Cancer Study, a population-based case-control study, and identified conditions under which disparities occurred in the assessments of the algorithm and the raters.Methods: Occupational diesel exhaust exposure was assessed previously using an algorithm and a single rater for all 14 983 jobs reported by 2631 study participants during personal interviews conducted from 2001 to 2004. Two additional raters independently assessed a random subset of 324 jobs that were selected based on strata defined by the cross-tabulations of the algorithm and the first rater's probability assessments for each job, oversampling their disagreements. The algorithm and each rater assessed the probability, intensity and frequency of occupational diesel exhaust exposure, as well as a confidence rating for each metric. Agreement among the raters, their aggregate rating (average of the three raters' ratings) and the algorithm were evaluated using proportion of agreement, kappa and weighted kappa (κw). Agreement analyses on the subset used inverse probability weighting to extrapolate the subset to estimate agreement for all jobs. Classification and Regression Tree (CART) models were used to identify patterns in questionnaire responses that predicted disparities in exposure status (i.e., unexposed versus exposed) between the first rater and the algorithm-based estimates.Results: For the probability, intensity and frequency exposure metrics, moderate to moderately high agreement was observed among raters (κw = 0.50-0.76) and between the algorithm and the individual raters (κw = 0.58-0.81). For these metrics, the algorithm estimates had consistently higher agreement with the aggregate rating (κw = 0.82) than with the individual raters. For all metrics, the agreement between the algorithm and the aggregate ratings was highest for the unexposed category (90-93%) and was poor to moderate for the exposed categories (9-64%). Lower agreement was observed for jobs with a start year

Published
2013

20. Inside the black box: Starting to uncover the underlying decision rules used in a one-by-one expert assessment of occupational exposure in case-control studies

Author

Wheeler, D.C., Burstyn, I., Vermeulen, R., Yu, K., Shortreed, S.M., Pronk, A., Stewart, P.A., Colt, J.S., Baris, D., Karagas, M.R., Schwenn, M., Johnson, A., Silverman, D.T., and Friesen, M.C.

Subjects
Life, Work and Employment, QS - Quality & Safety, EELS - Earth, Environmental and Life Sciences, Workplace, Healthy Living
Abstract

Objectives Evaluating occupational exposures in population-based case-control studies often requires exposure assessors to review each study participant's reported occupational information job-by-job to derive exposure estimates. Although such assessments likely have underlying decision rules, they usually lack transparency, are time consuming and have uncertain reliability and validity. We aimed to identify the underlying rules to enable documentation, review and future use of these expert-based exposure decisions. Methods Classification and regression trees (CART, predictions from a single tree) and random forests ( predictions from many trees) were used to identify the underlying rules from the questionnaire responses, and an expert's exposure assignments for occupational diesel exhaust exposure for several metrics: binary exposure probability and ordinal exposure probability, intensity and frequency. Data were split into training (n=10 488 jobs), testing (n=2247) and validation (n=2248) datasets. Results The CART and random forest models' predictions agreed with 92-94% of the expert's binary probability assignments. For ordinal probability, intensity and frequency metrics, the two models extracted decision rules more successfully for unexposed and highly exposed jobs (86-90% and 57-85%, respectively) than for low or medium exposed jobs (7-71%). Conclusions CART and random forest models extracted decision rules and accurately predicted an expert's exposure decisions for the majority of jobs, and identified questionnaire response patterns that would require further expert review if the rules were applied to other jobs in the same or different study. This approach makes the exposure assessment process in case-control studies more transparent, and creates a mechanism to efficiently replicate exposure decisions in future studies.

Published
2013

21. Comparison of two expert-based assessments of diesel exhaust exposure in a case-control study: Programmable decision rules versus expert review of individual jobs

Author

Pronk, A., Stewart, P.A., Coble, J.B., Katki, H.A., Wheeler, D.C., Colt, J.S., Baris, D., Schwenn, M., Karagas, M.R., Johnson, A., Waddell, R., Verrill, C., Cherala, S., Silverman, D.T., and Friesen, M.C.

Subjects
Life, Work and Employment, QS - Quality & Safety, EELS - Earth, Environmental and Life Sciences, Workplace, Healthy Living
Abstract

Objectives: Professional judgment is necessary to assess occupational exposure in population-based case-control studies; however, the assessments lack transparency and are time-consuming to perform. To improve transparency and efficiency, we systematically applied decision rules to questionnaire responses to assess diesel exhaust exposure in the population-based case-control New England Bladder Cancer Study. Methods: 2631 participants reported 14 983 jobs; 2749 jobs were administered questionnaires ('modules') with diesel-relevant questions. We applied decision rules to assign exposure metrics based either on the occupational history (OH) responses (OH estimates) or on the module responses (module estimates); we then combined the separate OH and module estimates (OH/module estimates). Each job was also reviewed individually to assign exposure (one-by-one review estimates). We evaluated the agreement between the OH, OH/module and one-by-one review estimates. Results: The proportion of exposed jobs was 20-25% for all jobs, depending on approach, and 54-60% for jobs with diesel-relevant modules. The OH/module and one-by- one review estimates had moderately high agreement for all jobs (κw=0.68-0.81) and for jobs with diesel-relevant modules (κw=0.62-0.78) for the probability, intensity and frequency metrics. For exposed subjects, the Spearman correlation statistic was 0.72 between the cumulative OH/module and one-by-one review estimates. Conclusions: The agreement seen here may represent an upper level of agreement because the algorithm and one-by-one review estimates were not fully independent. This study shows that applying decision-based rules can reproduce a one-by-one review, increase transparency and efficiency, and provide a mechanism to replicate exposure decisions in other studies.

Published
2012

22. Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33

Author

Wang, Z., primary, Zhu, B., additional, Zhang, M., additional, Parikh, H., additional, Jia, J., additional, Chung, C. C., additional, Sampson, J. N., additional, Hoskins, J. W., additional, Hutchinson, A., additional, Burdette, L., additional, Ibrahim, A., additional, Hautman, C., additional, Raj, P. S., additional, Abnet, C. C., additional, Adjei, A. A., additional, Ahlbom, A., additional, Albanes, D., additional, Allen, N. E., additional, Ambrosone, C. B., additional, Aldrich, M., additional, Amiano, P., additional, Amos, C., additional, Andersson, U., additional, Andriole, G., additional, Andrulis, I. L., additional, Arici, C., additional, Arslan, A. A., additional, Austin, M. A., additional, Baris, D., additional, Barkauskas, D. A., additional, Bassig, B. A., additional, Beane Freeman, L. E., additional, Berg, C. D., additional, Berndt, S. I., additional, Bertazzi, P. A., additional, Biritwum, R. B., additional, Black, A., additional, Blot, W., additional, Boeing, H., additional, Boffetta, P., additional, Bolton, K., additional, Boutron-Ruault, M.-C., additional, Bracci, P. M., additional, Brennan, P., additional, Brinton, L. A., additional, Brotzman, M., additional, Bueno-de-Mesquita, H. B., additional, Buring, J. E., additional, Butler, M. A., additional, Cai, Q., additional, Cancel-Tassin, G., additional, Canzian, F., additional, Cao, G., additional, Caporaso, N. E., additional, Carrato, A., additional, Carreon, T., additional, Carta, A., additional, Chang, G.-C., additional, Chang, I.-S., additional, Chang-Claude, J., additional, Che, X., additional, Chen, C.-J., additional, Chen, C.-Y., additional, Chen, C.-H., additional, Chen, C., additional, Chen, K.-Y., additional, Chen, Y.-M., additional, Chokkalingam, A. P., additional, Chu, L. W., additional, Clavel-Chapelon, F., additional, Colditz, G. A., additional, Colt, J. S., additional, Conti, D., additional, Cook, M. B., additional, Cortessis, V. K., additional, Crawford, E. D., additional, Cussenot, O., additional, Davis, F. G., additional, De Vivo, I., additional, Deng, X., additional, Ding, T., additional, Dinney, C. P., additional, Di Stefano, A. L., additional, Diver, W. R., additional, Duell, E. J., additional, Elena, J. W., additional, Fan, J.-H., additional, Feigelson, H. S., additional, Feychting, M., additional, Figueroa, J. D., additional, Flanagan, A. M., additional, Fraumeni, J. F., additional, Freedman, N. D., additional, Fridley, B. L., additional, Fuchs, C. S., additional, Gago-Dominguez, M., additional, Gallinger, S., additional, Gao, Y.-T., additional, Gapstur, S. M., additional, Garcia-Closas, M., additional, Garcia-Closas, R., additional, Gastier-Foster, J. M., additional, Gaziano, J. M., additional, Gerhard, D. S., additional, Giffen, C. A., additional, Giles, G. G., additional, Gillanders, E. M., additional, Giovannucci, E. L., additional, Goggins, M., additional, Gokgoz, N., additional, Goldstein, A. M., additional, Gonzalez, C., additional, Gorlick, R., additional, Greene, M. H., additional, Gross, M., additional, Grossman, H. B., additional, Grubb, R., additional, Gu, J., additional, Guan, P., additional, Haiman, C. A., additional, Hallmans, G., additional, Hankinson, S. E., additional, Harris, C. C., additional, Hartge, P., additional, Hattinger, C., additional, Hayes, R. B., additional, He, Q., additional, Helman, L., additional, Henderson, B. E., additional, Henriksson, R., additional, Hoffman-Bolton, J., additional, Hohensee, C., additional, Holly, E. A., additional, Hong, Y.-C., additional, Hoover, R. N., additional, Hosgood, H. D., additional, Hsiao, C.-F., additional, Hsing, A. W., additional, Hsiung, C. A., additional, Hu, N., additional, Hu, W., additional, Hu, Z., additional, Huang, M.-S., additional, Hunter, D. J., additional, Inskip, P. D., additional, Ito, H., additional, Jacobs, E. J., additional, Jacobs, K. B., additional, Jenab, M., additional, Ji, B.-T., additional, Johansen, C., additional, Johansson, M., additional, Johnson, A., additional, Kaaks, R., additional, Kamat, A. M., additional, Kamineni, A., additional, Karagas, M., additional, Khanna, C., additional, Khaw, K.-T., additional, Kim, C., additional, Kim, I.-S., additional, Kim, J. H., additional, Kim, Y. H., additional, Kim, Y.-C., additional, Kim, Y. T., additional, Kang, C. H., additional, Jung, Y. J., additional, Kitahara, C. M., additional, Klein, A. P., additional, Klein, R., additional, Kogevinas, M., additional, Koh, W.-P., additional, Kohno, T., additional, Kolonel, L. N., additional, Kooperberg, C., additional, Kratz, C. P., additional, Krogh, V., additional, Kunitoh, H., additional, Kurtz, R. C., additional, Kurucu, N., additional, Lan, Q., additional, Lathrop, M., additional, Lau, C. C., additional, Lecanda, F., additional, Lee, K.-M., additional, Lee, M. P., additional, Le Marchand, L., additional, Lerner, S. P., additional, Li, D., additional, Liao, L. M., additional, Lim, W.-Y., additional, Lin, D., additional, Lin, J., additional, Lindstrom, S., additional, Linet, M. S., additional, Lissowska, J., additional, Liu, J., additional, Ljungberg, B., additional, Lloreta, J., additional, Lu, D., additional, Ma, J., additional, Malats, N., additional, Mannisto, S., additional, Marina, N., additional, Mastrangelo, G., additional, Matsuo, K., additional, McGlynn, K. A., additional, McKean-Cowdin, R., additional, McNeill, L. H., additional, McWilliams, R. R., additional, Melin, B. S., additional, Meltzer, P. S., additional, Mensah, J. E., additional, Miao, X., additional, Michaud, D. S., additional, Mondul, A. M., additional, Moore, L. E., additional, Muir, K., additional, Niwa, S., additional, Olson, S. H., additional, Orr, N., additional, Panico, S., additional, Park, J. Y., additional, Patel, A. V., additional, Patino-Garcia, A., additional, Pavanello, S., additional, Peeters, P. H. M., additional, Peplonska, B., additional, Peters, U., additional, Petersen, G. M., additional, Picci, P., additional, Pike, M. C., additional, Porru, S., additional, Prescott, J., additional, Pu, X., additional, Purdue, M. P., additional, Qiao, Y.-L., additional, Rajaraman, P., additional, Riboli, E., additional, Risch, H. A., additional, Rodabough, R. J., additional, Rothman, N., additional, Ruder, A. M., additional, Ryu, J.-S., additional, Sanson, M., additional, Schned, A., additional, Schumacher, F. R., additional, Schwartz, A. G., additional, Schwartz, K. L., additional, Schwenn, M., additional, Scotlandi, K., additional, Seow, A., additional, Serra, C., additional, Serra, M., additional, Sesso, H. D., additional, Severi, G., additional, Shen, H., additional, Shen, M., additional, Shete, S., additional, Shiraishi, K., additional, Shu, X.-O., additional, Siddiq, A., additional, Sierrasesumaga, L., additional, Sierri, S., additional, Loon Sihoe, A. D., additional, Silverman, D. T., additional, Simon, M., additional, Southey, M. C., additional, Spector, L., additional, Spitz, M., additional, Stampfer, M., additional, Stattin, P., additional, Stern, M. C., additional, Stevens, V. L., additional, Stolzenberg-Solomon, R. Z., additional, Stram, D. O., additional, Strom, S. S., additional, Su, W.-C., additional, Sund, M., additional, Sung, S. W., additional, Swerdlow, A., additional, Tan, W., additional, Tanaka, H., additional, Tang, W., additional, Tang, Z.-Z., additional, Tardon, A., additional, Tay, E., additional, Taylor, P. R., additional, Tettey, Y., additional, Thomas, D. M., additional, Tirabosco, R., additional, Tjonneland, A., additional, Tobias, G. S., additional, Toro, J. R., additional, Travis, R. C., additional, Trichopoulos, D., additional, Troisi, R., additional, Truelove, A., additional, Tsai, Y.-H., additional, Tucker, M. A., additional, Tumino, R., additional, Van Den Berg, D., additional, Van Den Eeden, S. K., additional, Vermeulen, R., additional, Vineis, P., additional, Visvanathan, K., additional, Vogel, U., additional, Wang, C., additional, Wang, J., additional, Wang, S. S., additional, Weiderpass, E., additional, Weinstein, S. J., additional, Wentzensen, N., additional, Wheeler, W., additional, White, E., additional, Wiencke, J. K., additional, Wolk, A., additional, Wolpin, B. M., additional, Wong, M. P., additional, Wrensch, M., additional, Wu, C., additional, Wu, T., additional, Wu, X., additional, Wu, Y.-L., additional, Wunder, J. S., additional, Xiang, Y.-B., additional, Xu, J., additional, Yang, H. P., additional, Yang, P.-C., additional, Yatabe, Y., additional, Ye, Y., additional, Yeboah, E. D., additional, Yin, Z., additional, Ying, C., additional, Yu, C.-J., additional, Yu, K., additional, Yuan, J.-M., additional, Zanetti, K. A., additional, Zeleniuch-Jacquotte, A., additional, Zheng, W., additional, Zhou, B., additional, Mirabello, L., additional, Savage, S. A., additional, Kraft, P., additional, Chanock, S. J., additional, Yeager, M., additional, Landi, M. T., additional, Shi, J., additional, Chatterjee, N., additional, and Amundadottir, L. T., additional

Published
2014
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23. Genome-wide interaction study of smoking and bladder cancer risk

Author

Figueroa, J. D., primary, Han, S. S., additional, Garcia-Closas, M., additional, Baris, D., additional, Jacobs, E. J., additional, Kogevinas, M., additional, Schwenn, M., additional, Malats, N., additional, Johnson, A., additional, Purdue, M. P., additional, Caporaso, N., additional, Landi, M. T., additional, Prokunina-Olsson, L., additional, Wang, Z., additional, Hutchinson, A., additional, Burdette, L., additional, Wheeler, W., additional, Vineis, P., additional, Siddiq, A., additional, Cortessis, V. K., additional, Kooperberg, C., additional, Cussenot, O., additional, Benhamou, S., additional, Prescott, J., additional, Porru, S., additional, Bueno-de-Mesquita, H. B., additional, Trichopoulos, D., additional, Ljungberg, B., additional, Clavel-Chapelon, F., additional, Weiderpass, E., additional, Krogh, V., additional, Dorronsoro, M., additional, Travis, R., additional, Tjonneland, A., additional, Brenan, P., additional, Chang-Claude, J., additional, Riboli, E., additional, Conti, D., additional, Gago-Dominguez, M., additional, Stern, M. C., additional, Pike, M. C., additional, Van Den Berg, D., additional, Yuan, J.-M., additional, Hohensee, C., additional, Rodabough, R., additional, Cancel-Tassin, G., additional, Roupret, M., additional, Comperat, E., additional, Chen, C., additional, De Vivo, I., additional, Giovannucci, E., additional, Hunter, D. J., additional, Kraft, P., additional, Lindstrom, S., additional, Carta, A., additional, Pavanello, S., additional, Arici, C., additional, Mastrangelo, G., additional, Karagas, M. R., additional, Schned, A., additional, Armenti, K. R., additional, Hosain, G. M. M., additional, Haiman, C. A., additional, Fraumeni, J. F., additional, Chanock, S. J., additional, Chatterjee, N., additional, Rothman, N., additional, and Silverman, D. T., additional

Published
2014
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24. Detectable clonal mosaicism and its relationship to aging and cancer

Author

Jacobs, KB, Yeager, M, Zhou, W, Wacholder, S, Wang, Z, Rodriguez-Santiago, B, Hutchinson, A, Deng, X, Liu, C, Horner, M-J, Cullen, M, Epstein, CG, Burdett, L, Dean, MC, Chatterjee, N, Sampson, J, Chung, CC, Kovaks, J, Gapstur, SM, Stevens, VL, Teras, LT, Gaudet, MM, Albanes, D, Weinstein, SJ, Virtamo, J, Taylor, PR, Freedman, ND, Abnet, CC, Goldstein, AM, Hu, N, Yu, K, Yuan, J-M, Liao, L, Ding, T, Qiao, Y-L, Gao, Y-T, Koh, W-P, Xiang, Y-B, Tang, Z-Z, Fan, J-H, Aldrich, MC, Amos, C, Blot, WJ, Bock, CH, Gillanders, EM, Harris, CC, Haiman, CA, Henderson, BE, Kolonel, LN, Le Marchand, L, McNeill, LH, Rybicki, BA, Schwartz, AG, Signorello, LB, Spitz, MR, Wiencke, JK, Wrensch, M, Wu, X, Zanetti, KA, Ziegler, RG, Figueroa, JD, Garcia-Closas, M, Malats, N, Marenne, G, Prokunina-Olsson, L, Baris, D, Schwenn, M, Johnson, A, Landi, MT, Goldin, L, Consonni, D, Bertazzi, PA, Rotunno, M, Rajaraman, P, Andersson, U, Freeman, LEB, Berg, CD, Buring, JE, Butler, MA, Carreon, T, Feychting, M, Ahlbom, A, Gaziano, JM, Giles, GG, Hallmans, G, Hankinson, SE, Hartge, P, Henriksson, R, Inskip, PD, Johansen, C, Landgren, A, McKean-Cowdin, R, Michaud, DS, Melin, BS, Peters, U, Ruder, AM, Sesso, HD, Severi, G, Shu, X-O, Visvanathan, K, White, E, Wolk, A, Zeleniuch-Jacquotte, A, Zheng, W, Silverman, DT, Kogevinas, M, Gonzalez, JR, Villa, O, Li, D, Duell, EJ, Risch, HA, Olson, SH, Kooperberg, C, Wolpin, BM, Jiao, L, Hassan, M, Wheeler, W, Arslan, AA, Bueno-de-Mesquita, HB, Fuchs, CS, Gallinger, S, Gross, MD, Holly, EA, Klein, AP, LaCroix, A, Mandelson, MT, Petersen, G, Boutron-Ruault, M-C, Bracci, PM, Canzian, F, Chang, K, Cotterchio, M, Giovannucci, EL, Goggins, M, Bolton, JAH, Jenab, M, Khaw, K-T, Krogh, V, Kurtz, RC, McWilliams, RR, Mendelsohn, JB, Rabe, KG, Riboli, E, Tjonneland, A, Tobias, GS, Trichopoulos, D, Elena, JW, Yu, H, Amundadottir, L, Stolzenberg-Solomon, RZ, Kraft, P, Schumacher, F, Stram, D, Savage, SA, Mirabello, L, Andrulis, IL, Wunder, JS, Patino Garcia, A, Sierrasesumaga, L, Barkauskas, DA, Gorlick, RG, Purdue, M, Chow, W-H, Moore, LE, Schwartz, KL, Davis, FG, Hsing, AW, Berndt, SI, Black, A, Wentzensen, N, Brinton, LA, Lissowska, J, Peplonska, B, McGlynn, KA, Cook, MB, Graubard, BI, Kratz, CP, Greene, MH, Erickson, RL, Hunter, DJ, Thomas, G, Hoover, RN, Real, FX, Fraumeni, JF, Caporaso, NE, Tucker, M, Rothman, N, Perez-Jurado, LA, Chanock, SJ, Jacobs, KB, Yeager, M, Zhou, W, Wacholder, S, Wang, Z, Rodriguez-Santiago, B, Hutchinson, A, Deng, X, Liu, C, Horner, M-J, Cullen, M, Epstein, CG, Burdett, L, Dean, MC, Chatterjee, N, Sampson, J, Chung, CC, Kovaks, J, Gapstur, SM, Stevens, VL, Teras, LT, Gaudet, MM, Albanes, D, Weinstein, SJ, Virtamo, J, Taylor, PR, Freedman, ND, Abnet, CC, Goldstein, AM, Hu, N, Yu, K, Yuan, J-M, Liao, L, Ding, T, Qiao, Y-L, Gao, Y-T, Koh, W-P, Xiang, Y-B, Tang, Z-Z, Fan, J-H, Aldrich, MC, Amos, C, Blot, WJ, Bock, CH, Gillanders, EM, Harris, CC, Haiman, CA, Henderson, BE, Kolonel, LN, Le Marchand, L, McNeill, LH, Rybicki, BA, Schwartz, AG, Signorello, LB, Spitz, MR, Wiencke, JK, Wrensch, M, Wu, X, Zanetti, KA, Ziegler, RG, Figueroa, JD, Garcia-Closas, M, Malats, N, Marenne, G, Prokunina-Olsson, L, Baris, D, Schwenn, M, Johnson, A, Landi, MT, Goldin, L, Consonni, D, Bertazzi, PA, Rotunno, M, Rajaraman, P, Andersson, U, Freeman, LEB, Berg, CD, Buring, JE, Butler, MA, Carreon, T, Feychting, M, Ahlbom, A, Gaziano, JM, Giles, GG, Hallmans, G, Hankinson, SE, Hartge, P, Henriksson, R, Inskip, PD, Johansen, C, Landgren, A, McKean-Cowdin, R, Michaud, DS, Melin, BS, Peters, U, Ruder, AM, Sesso, HD, Severi, G, Shu, X-O, Visvanathan, K, White, E, Wolk, A, Zeleniuch-Jacquotte, A, Zheng, W, Silverman, DT, Kogevinas, M, Gonzalez, JR, Villa, O, Li, D, Duell, EJ, Risch, HA, Olson, SH, Kooperberg, C, Wolpin, BM, Jiao, L, Hassan, M, Wheeler, W, Arslan, AA, Bueno-de-Mesquita, HB, Fuchs, CS, Gallinger, S, Gross, MD, Holly, EA, Klein, AP, LaCroix, A, Mandelson, MT, Petersen, G, Boutron-Ruault, M-C, Bracci, PM, Canzian, F, Chang, K, Cotterchio, M, Giovannucci, EL, Goggins, M, Bolton, JAH, Jenab, M, Khaw, K-T, Krogh, V, Kurtz, RC, McWilliams, RR, Mendelsohn, JB, Rabe, KG, Riboli, E, Tjonneland, A, Tobias, GS, Trichopoulos, D, Elena, JW, Yu, H, Amundadottir, L, Stolzenberg-Solomon, RZ, Kraft, P, Schumacher, F, Stram, D, Savage, SA, Mirabello, L, Andrulis, IL, Wunder, JS, Patino Garcia, A, Sierrasesumaga, L, Barkauskas, DA, Gorlick, RG, Purdue, M, Chow, W-H, Moore, LE, Schwartz, KL, Davis, FG, Hsing, AW, Berndt, SI, Black, A, Wentzensen, N, Brinton, LA, Lissowska, J, Peplonska, B, McGlynn, KA, Cook, MB, Graubard, BI, Kratz, CP, Greene, MH, Erickson, RL, Hunter, DJ, Thomas, G, Hoover, RN, Real, FX, Fraumeni, JF, Caporaso, NE, Tucker, M, Rothman, N, Perez-Jurado, LA, and Chanock, SJ

Abstract

In an analysis of 31,717 cancer cases and 26,136 cancer-free controls from 13 genome-wide association studies, we observed large chromosomal abnormalities in a subset of clones in DNA obtained from blood or buccal samples. We observed mosaic abnormalities, either aneuploidy or copy-neutral loss of heterozygosity, of >2 Mb in size in autosomes of 517 individuals (0.89%), with abnormal cell proportions of between 7% and 95%. In cancer-free individuals, frequency increased with age, from 0.23% under 50 years to 1.91% between 75 and 79 years (P = 4.8 × 10(-8)). Mosaic abnormalities were more frequent in individuals with solid tumors (0.97% versus 0.74% in cancer-free individuals; odds ratio (OR) = 1.25; P = 0.016), with stronger association with cases who had DNA collected before diagnosis or treatment (OR = 1.45; P = 0.0005). Detectable mosaicism was also more common in individuals for whom DNA was collected at least 1 year before diagnosis with leukemia compared to cancer-free individuals (OR = 35.4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases.

Published
2012

25. A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.

Author

Garcia-Closas, M., Chatterjee, N., Malats, N., Wu, X., Figueroa, J.D., Real, F.X., Berg, D.P.G. van den, Matullo, G., Baris, D., Thun, M., Kiemeney, L.A.L.M., Vilneis, P., De Vivo, I., Albanes, D., Purdue, M., Rafnar, T., Hildebrandt, M.A.T., Kiltie, A.E., Cussenot, O., Golka, K., Kumar, R., Taylor, J.A., Mayordomo, J.I., Jacobs, K.B., Kogevinas, M., Hutchinson, A., Wang, Z., Fu, Y., Prokunina-Olsson, L., Burdett, L., Yeager, M., Wheeler, W., Tardon, A., Serra, C., Carrato, A., Garcia-Closas, R., Lloreta, J., Johnson, A., Schwenn, M., Karagas, M.R., Schned, A., Andriole, G.L., Grubb, R., Black, A., Jacobs, E.J., Diver, W.R., Gapstur, S.M., Weinstein, S.J., Virtamo, J., Cortessis, V.K., Gago-Dominguez, M., Pike, M.C., Stern, M.C., Yuan, J.M., Hunter, D.J., McGrath, M., Dinney, C.P., Czerniak, B., Chen, M., Yang, H., Vermeulen, S., Aben, K.K.H., Witjes, J.A., Makkinje, R.R., Sulem, P., Besenbacher, S., Riboli, E., Brennan, P., Panico, S., Navarro, C, Allen, N.E., Bueno-De-Mesquita, H.B., Trichopoulos, D., Caporaso, N., Landi, M.T., Canzian, F., Ljungberg, B, Tjonneland, A., Clavel-Chapelon, F., Bishop, D.T., Teo, M.T., Knowles, M.A., Guarrera, S., Polidoro, S., Ricceri, F., Sacerdote, C., Allione, A., Cancel-Tassin, G., Selinski, S., Hengstler, J.G., Dietrich, H., Fletcher, T., Rudnai, P., Gurzau, E, Koppova, K., Bolick, S.C., Godfrey, A., Xu, Z., Garcia-Closas, M., Chatterjee, N., Malats, N., Wu, X., Figueroa, J.D., Real, F.X., Berg, D.P.G. van den, Matullo, G., Baris, D., Thun, M., Kiemeney, L.A.L.M., Vilneis, P., De Vivo, I., Albanes, D., Purdue, M., Rafnar, T., Hildebrandt, M.A.T., Kiltie, A.E., Cussenot, O., Golka, K., Kumar, R., Taylor, J.A., Mayordomo, J.I., Jacobs, K.B., Kogevinas, M., Hutchinson, A., Wang, Z., Fu, Y., Prokunina-Olsson, L., Burdett, L., Yeager, M., Wheeler, W., Tardon, A., Serra, C., Carrato, A., Garcia-Closas, R., Lloreta, J., Johnson, A., Schwenn, M., Karagas, M.R., Schned, A., Andriole, G.L., Grubb, R., Black, A., Jacobs, E.J., Diver, W.R., Gapstur, S.M., Weinstein, S.J., Virtamo, J., Cortessis, V.K., Gago-Dominguez, M., Pike, M.C., Stern, M.C., Yuan, J.M., Hunter, D.J., McGrath, M., Dinney, C.P., Czerniak, B., Chen, M., Yang, H., Vermeulen, S., Aben, K.K.H., Witjes, J.A., Makkinje, R.R., Sulem, P., Besenbacher, S., Riboli, E., Brennan, P., Panico, S., Navarro, C, Allen, N.E., Bueno-De-Mesquita, H.B., Trichopoulos, D., Caporaso, N., Landi, M.T., Canzian, F., Ljungberg, B, Tjonneland, A., Clavel-Chapelon, F., Bishop, D.T., Teo, M.T., Knowles, M.A., Guarrera, S., Polidoro, S., Ricceri, F., Sacerdote, C., Allione, A., Cancel-Tassin, G., Selinski, S., Hengstler, J.G., Dietrich, H., Fletcher, T., Rudnai, P., Gurzau, E, Koppova, K., Bolick, S.C., Godfrey, A., and Xu, Z.

Abstract

Contains fulltext : 88946.pdf (publisher's version ) (Closed access)

Published
2010

26. Dietary intake of meat, fruits, vegetables, and selective micronutrients and risk of bladder cancer in the New England region of the United States

Author

Wu, J W, primary, Cross, A J, additional, Baris, D, additional, Ward, M H, additional, Karagas, M R, additional, Johnson, A, additional, Schwenn, M, additional, Cherala, S, additional, Colt, J S, additional, Cantor, K P, additional, Rothman, N, additional, Silverman, D T, additional, and Sinha, R, additional

Published
2012
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27. Abstract LB-337: Synergistic effects of twelve common genetic polymorphisms and smoking habits on absolute risk of bladder cancer

Author

García-Closas, M., primary, Rothman, N., additional, Figueroa, J. D., additional, Prokunina-Olsson, L., additional, Han, S., additional, Baris, D., additional, Jacobs, E., additional, Malats, N., additional, Vivo, I. De, additional, Albanes, D., additional, Purdue, M. P., additional, Sharma, S., additional, Fu, Y. P., additional, Kogevinas, M., additional, Wang, Z., additional, Tang, W., additional, Tardón, A., additional, Serra, C., additional, Carrato, A., additional, García-Closas, R., additional, Lloreta, J., additional, Johnson, A., additional, Schwenn, M., additional, Karagas, M. R., additional, Schned, A., additional, Andriole, G., additional, Grubb, R., additional, Black, A., additional, Gapstur, S. M., additional, Thun, M., additional, Diver, W. R., additional, Weinstein, S. J., additional, Virtamo, J., additional, Hunter, D. J., additional, Caporaso, N., additional, Landi, M. T., additional, Hutchinson, A., additional, Burdett, L., additional, Jacobs, K. B., additional, Yeager, M., additional, Fraumeni, J. F., additional, Chanock, S. J., additional, Silverman, D. T., additional, and Chatterjee, N., additional

Published
2012
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28. GSTM1 null and NAT2 slow acetylation genotypes, smoking intensity and bladder cancer risk: results from the New England bladder cancer study and NAT2 meta-analysis

Author

Moore, L. E., primary, Baris, D. R., additional, Figueroa, J. D., additional, Garcia-Closas, M., additional, Karagas, M. R., additional, Schwenn, M. R., additional, Johnson, A. T., additional, Lubin, J. H., additional, Hein, D. W., additional, Dagnall, C. L., additional, Colt, J. S., additional, Kida, M., additional, Jones, M. A., additional, Schned, A. R., additional, Cherala, S. S., additional, Chanock, S. J., additional, Cantor, K. P., additional, Silverman, D. T., additional, and Rothman, N., additional

Published
2010
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29. Occupation and bladder cancer in a population-based case-control study in Northern New England

Author

Colt, J. S., primary, Karagas, M. R., additional, Schwenn, M., additional, Baris, D., additional, Johnson, A., additional, Stewart, P., additional, Verrill, C., additional, Moore, L. E., additional, Lubin, J., additional, Ward, M. H., additional, Samanic, C., additional, Rothman, N., additional, Cantor, K. P., additional, Beane Freeman, L. E., additional, Schned, A., additional, Cherala, S., additional, and Silverman, D. T., additional

Published
2010
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33. A case-control study of smoking and bladder cancer risk: emergent patterns over time.

Author

Baris D, Karagas MR, Verrill C, Johnson A, Andrew AS, Marsit CJ, Schwenn M, Colt JS, Cherala S, Samanic C, Waddell R, Cantor KP, Schned A, Rothman N, Lubin J, Fraumeni JF Jr, Hoover RN, Kelsey KT, Silverman DT, and Baris, Dalsu

Abstract

Background: Cigarette smoking is a well-established risk factor for bladder cancer. The effects of smoking duration, intensity (cigarettes per day), and total exposure (pack-years); smoking cessation; exposure to environmental tobacco smoke; and changes in the composition of tobacco and cigarette design over time on risk of bladder cancer are unclear.Methods: We examined bladder cancer risk in relation to smoking practices based on interview data from a large, population-based case-control study conducted in Maine, New Hampshire, and Vermont from 2001 to 2004 (N = 1170 urothelial carcinoma case patients and 1413 control subjects). We calculated odds ratios (ORs) and 95% confidence intervals (CIs) using unconditional logistic regression. To examine changes in smoking-induced bladder cancer risk over time, we compared odds ratios from New Hampshire residents in this study (305 case patients and 335 control subjects) with those from two case-control studies conducted in New Hampshire in 1994-1998 and in 1998-2001 (843 case patients and 1183 control subjects).Results: Regular and current cigarette smokers had higher risks of bladder cancer than never-smokers (for regular smokers, OR = 3.0, 95% CI = 2.4 to 3.6; for current smokers, OR = 5.2, 95% CI = 4.0 to 6.6). In New Hampshire, there was a statistically significant increasing trend in smoking-related bladder cancer risk over three consecutive periods (1994-1998, 1998-2001, and 2002-2004) among former smokers (OR = 1.4, 95% CI = 1.0 to 2.0; OR = 2.0, 95% CI = 1.4 to 2.9; and OR = 2.6, 95% CI = 1.7 to 4.0, respectively) and current smokers (OR = 2.9, 95% CI = 2.0 to 4.2; OR = 4.2, 95% CI = 2.8 to 6.3; OR = 5.5, 95% CI = 3.5 to 8.9, respectively) (P for homogeneity of trends over time periods = .04). We also observed that within categories of intensity, odds ratios increased approximately linearly with increasing pack-years smoked, but the slope of the increasing trend declined with increasing intensity.Conclusions: Smoking-related risks of bladder cancer appear to have increased in New Hampshire since the mid-1990s. Based on our modeling of pack-years and intensity, smoking fewer cigarettes over a long time appears more harmful than smoking more cigarettes over a shorter time, for equal total pack-years of cigarettes smoked. [ABSTRACT FROM AUTHOR]

Published
2009
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35. Acute lymphoblastic leukemia with the (8;14)(q24;q32) translocation and FAB L3 morphology associated with a B-precursor immunophenotype: the Pediatric Oncology Group experience.

Author

Navid, F, Mosijczuk, A D, Head, D R, Borowitz, M J, Carroll, A J, Brandt, J M, Link, M P, Rozans, M K, Thomas, G A, Schwenn, M R, Shields, D J, Vietti, T J, and Pullen, D J

Subjects
LYMPHOBLASTIC leukemia, IMMUNOPHENOTYPING
Abstract

Five pediatric patients are described with acute lymphoblastic leukemia (ALL) who at presentation had clinical findings suggestive of B cell ALL and lymphoblasts with FAB L3 morphology and the characteristic t(8;14)(q24;q32). However, the leukemia cells of all five patients failed to express surface immunoglobulin (sIg) and kappa or lambda light chains. Based on initial immunophenotyping results consistent with B-precursor ALL, four of these cases were initially treated with conventional ALL chemotherapy. These four patients were switched to B cell ALL treatment protocols once cytogenetic results became available revealing the 8;14 translocation. The fifth case was treated with B cell ALL therapy from the outset. Four of the five patients are in complete remission at 64, 36, 29 and 13 months from diagnosis. One patient relapsed and died 6 months after initial presentation. These five unusual cases with clinical B cell ALL, the t(8;14), and FAB L3 morphology, but negative sIg, demonstrate the importance of careful and multidisciplinary evaluation of leukemic cells with morphology, cytochemistry, immunophenotyping and cytogenetic analysis. Future identification of patients with this profile will allow us to expand our knowledge regarding prognostic significance and optimal treatment for this rare subgroup of patients. [ABSTRACT FROM AUTHOR]

Published
1999
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36. Ifosfamide/etoposide combination in the treatment of recurrent malignant solid tumors of childhood. A Pediatric Oncology Group Phase II study.

Author

Kung, Faith H., Pratt, Charles B., Vega, Roger A., Jaffe, Norman, Strother, Douglas, Schwenn, Molly, Nitschke, Ruprecht, Homans, Alan C., Holbrook, C. Tate, Golembe, Barry, Bernstein, Mark, Krischer, Jeffrey P., Kung, F H, Pratt, C B, Vega, R A, Jaffe, N, Strother, D, Schwenn, M, Nitschke, R, and Homans, A C

Published
1993
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42. Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33

Author

Hidemi Ito, Stephen K. Van Den Eeden, Abdisamad M. Ibrahim, Ching C. Lau, Preetha Rajaraman, Gloria M. Petersen, Judith Hoffman-Bolton, Colin P.N. Dinney, Chang Hyun Kang, Melinda C. Aldrich, Mark P. Purdue, Xiao-Ou Shu, William J. Blot, Sanjay Shete, Alpa V. Patel, Charles Kooperberg, Paolo Vineis, David Van Den Berg, Chao A. Hsiung, Anthony J. Swerdlow, Qing Lan, Wu Chou Su, Afshan Siddiq, Ulrike Peters, Katia Scotlandi, Sara H. Olson, Kendra Schwartz, Kelly L. Bolton, Chancellor Hohensee, Josep Lloreta, Kevin B. Jacobs, Debra T. Silverman, Rudolf Kaaks, Wei Zheng, Steven Gallinger, Junwen Wang, Angela Carta, Massimo Serra, Petra H.M. Peeters, Victoria L. Stevens, Yasushi Yatabe, Geraldine Cancel-Tassin, Joshua N. Sampson, Young Tae Kim, Graham A. Colditz, Pan-Chyr Yang, Baosen Zhou, Fredrick R. Schumacher, Nicolas Wentzensen, Evelyn Tay, Claudia Maria Hattinger, Chen Wu, Pilar Amiano, Mattias Johansson, Maxwell P. Lee, Christian P. Kratz, Michael B. Cook, Mingfeng Zhang, Kay-Tee Khaw, Jian-Min Yuan, Anne Zeleniuch-Jacquotte, Jinping Jia, Roberto Tirabosco, Jing Ma, Neil E. Caporaso, Christopher A. Haiman, Bu Tian Ji, Adrienne M. Flanagan, Neyssa Marina, Eric J. Jacobs, Sophia S. Wang, Chong-Jen Yu, Edward Giovannucci, Margaret Wrensch, Robert L. Grubb, Bin Zhu, Daniel O. Stram, Manolis Kogevinas, Margaret R. Karagas, Mazda Jenab, Alison M. Mondul, Jun Xu, Preethi S. Raj, Anders Ahlbom, Christine D. Berg, Shelley Niwa, Kala Visvanathan, Loic Le Marchand, Jorge R. Toro, Robert N. Hoover, Heather Spencer Feigelson, Michelle Brotzman, Laurence N. Kolonel, Krista A. Zanetti, Chengfeng Wang, Mary Ann Butler, Ann Truelove, Irene L. Andrulis, Hongbing Shen, H. Dean Hosgood, Ming Shyan Huang, Gee-Chen Chang, Jianjun Liu, John K. Wiencke, Stephanie J. Weinstein, Beatrice Melin, Kouya Shiraishi, Zhihua Yin, Lee E. Moore, Börje Ljungberg, Jolanta Lissowska, Elizabeth M. Gillanders, M. T. Landi, Cari M. Kitahara, Maria Feychting, Kuan-Yu Chen, Matthias Simon, Brian M. Wolpin, Hemang Parikh, Hannah P. Yang, Graham G. Giles, Alison Johnson, Demetrius Albanes, Carlos González, Brian E. Henderson, Xifeng Wu, Harvey A. Risch, Amy Hutchinson, Christopher Hautman, Constance Chen, Zhibin Hu, Donghui Li, Elio Riboli, Julie E. Buring, Curtis C. Harris, Xu Che, Núria Malats, Roger Henriksson, Rosario Tumino, Joanne S. Colt, Alfredo Carrato, Paolo Boffetta, Maria Pik Wong, Hideo Tanaka, Federico Canzian, Alan D. L. Sihoe, Chien-Jen Chen, Kenneth Muir, Chen Ying, Qincheng He, Melissa C. Southey, Marc Sanson, Victoria K. Cortessis, Sharon A. Savage, Wei Hu, Yao Tettey, Daniela S. Gerhard, Sofia Pavanello, Guangwen Cao, H. Barton Grossman, Michael Goggins, Hideo Kunitoh, Peter D. Inskip, Seth P. Lerner, Peter Kraft, David Thomas, Peng Guan, Chung Hsing Chen, I. Shou Chang, Christoffer Johansen, Roberta McKean-Cowdin, Lee J. Helman, Yuh Min Chen, Ana Patiño-García, Pär Stattin, Xiaoping Miao, Tangchun Wu, Jay S. Wunder, Ann W. Hsing, Yu-Tang Gao, Brooke L. Fridley, Tania Carreón, Charles C. Chung, Nan Hu, Yoo Jin Jung, Richard B. Biritwum, Eric J. Duell, Philip R. Taylor, Satu Männistö, Kai Yu, Meredith Yeager, Xia Pu, Vittorio Krogh, Anand P. Chokkalingam, Susan M. Gapstur, W. Ryan Diver, Yuanqing Ye, Keitaro Matsuo, Cecilia Arici, You-Lin Qiao, Alan R. Schned, Dominique S. Michaud, Joanne W. Elena, Christopher Kim, Dongxin Lin, Yun-Chul Hong, Daru Lu, Reina García-Closas, Jonine D. Figueroa, Linda M. Liao, Yi-Long Wu, Heiner Boeing, Mark Lathrop, Göran Hallmans, Elizabeth A. Holly, Carol Giffen, Andrew A. Adjei, Consol Serra, Anne Tjønneland, Joseph F. Fraumeni, Alisa M. Goldstein, Ruth C. Travis, Rebecca Troisi, Dalsu Baris, Nalan Gokgoz, Olivier Cussenot, Xiang Deng, Yeul Hong Kim, Malin Sund, Sonja I. Berndt, E. David Crawford, Edward D. Yeboah, Sook Whan Sung, Françoise Clavel-Chapelon, Woon-Puay Koh, Nilgun Kurucu, Richard B. Hayes, Ashish M. Kamat, Beata Peplonska, Laurie Burdette, Ze Zhang Tang, Alan A. Arslan, Malcolm C. Pike, Sabina Sierri, J. Michael Gaziano, Lorna H. McNeil, Katherine A. McGlynn, Ulla Vogel, Logan G. Spector, H. Bas Bueno-de-Mesquita, Stephen J. Chanock, Jae Yong Park, Jennifer Prescott, Fernando Lecanda, Margaret A. Tucker, Ti Ding, Christian C. Abnet, Jenny Chang-Claude, Dimitrios Trichopoulos, Wei-Yen Lim, Wen Tan, Nick Orr, Jin Hee Kim, Stefano Porru, Chand Khanna, Robert R. McWilliams, Zhaoming Wang, Jeong Seon Ryu, David V. Conti, Alison P. Klein, Adonina Tardón, Robert J. Klein, Rebecca J. Rodabough, Mark H. Greene, Aruna Kamineni, Jie Lin, Rachael Z. Stolzenberg-Solomon, Patricia Hartge, Susan E. Hankinson, Young-Chul Kim, In Sam Kim, Luis Sierrasesúmaga, Roel Vermeulen, Paige M. Bracci, Mariana C. Stern, Louise A. Brinton, Myron D. Gross, Yong-Bing Xiang, Chih Yi Chen, G. A. Gerald Andriole, Paul S. Meltzer, Ying-Huang Tsai, Faith G. Davis, Ulrika Andersson, Paul Brennan, Sara Lindström, Chaoyu Wang, Giuseppe Mastrangelo, Laufey T. Amundadottir, Immaculata De Vivo, Bryan A. Bassig, Elisabete Weiderpass, Takashi Kohno, Nilanjan Chatterjee, Margaret R. Spitz, Pier Alberto Bertazzi, William Wheeler, David J. Hunter, Wei Tang, Qiuyin Cai, Naomi E. Allen, Molly Schwenn, Emily White, Min Shen, Adeline Seow, Laura E. Beane Freeman, James E. Mensah, Howard D. Sesso, Anna Luisa Di Stefano, Amanda Black, Manuela Gago-Dominguez, Christine B. Ambrosone, Avima M. Ruder, Martha S. Linet, Meir J. Stampfer, Robert C. Kurtz, Donald A. Barkauskas, Lisa W. Chu, Montserrat Garcia-Closas, Jason W. Hoskins, Melissa A. Austin, Kyoung Mu Lee, Jianxin Shi, Charles S. Fuchs, Nathaniel Rothman, Richard Gorlick, Piero Picci, Gianluca Severi, Ann G. Schwartz, Jian Gu, Christopher I. Amos, Marie-Christine Boutron-Ruault, Salvatore Panico, Alicja Wolk, Sara S. Strom, Lisa Mirabello, Jin-Hu Fan, Chin-Fu Hsiao, Neal D. Freedman, Geoffrey S. Tobias, Julie M. Gastier-Foster, Wang, Z, Zhu, B, Zhang, M, Parikh, H, Jia, J, Chung, Cc, Sampson, Jn, Hoskins, Jw, Hutchinson, A, Burdette, L, Ibrahim, A, Hautman, C, Raj, P, Abnet, Cc, Adjei, Aa, Ahlbom, A, Albanes, D, Allen, Ne, Ambrosone, Cb, Aldrich, M, Amiano, P, Amos, C, Andersson, U, Andriole G., Jr, Andrulis, Il, Arici, C, Arslan, Aa, Austin, Ma, Baris, D, Barkauskas, Da, Bassig, Ba, Beane Freeman, Le, Berg, Cd, Berndt, Si, Bertazzi, Pa, Biritwum, Rb, Black, A, Blot, W, Boeing, H, Boffetta, P, Bolton, K, Boutron Ruault, Mc, Bracci, Pm, Brennan, P, Brinton, La, Brotzman, M, Bueno de Mesquita, Hb, Buring, Je, Butler, Ma, Cai, Q, Cancel Tassin, G, Canzian, F, Cao, G, Caporaso, Ne, Carrato, A, Carreon, T, Carta, A, Chang, Gc, Chang, I, Chang Claude, J, Che, X, Chen, Cj, Chen, Cy, Chen, Ch, Chen, C, Chen, Ky, Chen, Ym, Chokkalingam, Ap, Chu, Lw, Clavel Chapelon, F, Colditz, Ga, Colt, J, Conti, D, Cook, Mb, Cortessis, Vk, Crawford, Ed, Cussenot, O, Davis, Fg, De Vivo, I, Deng, X, Ding, T, Dinney, Cp, Di Stefano, Al, Diver, Wr, Duell, Ej, Elena, Jw, Fan, Jh, Feigelson, H, Feychting, M, Figueroa, Jd, Flanagan, Am, Fraumeni JF, Jr, Freedman, Nd, Fridley, Bl, Fuchs, C, Gago Dominguez, M, Gallinger, S, Gao, Yt, Gapstur, Sm, Garcia Closas, M, Garcia Closas, R, Gastier Foster, Jm, Gaziano, Jm, Gerhard, D, Giffen, Ca, Giles, Gg, Gillanders, Em, Giovannucci, El, Goggins, M, Gokgoz, N, Goldstein, Am, Gonzalez, C, Gorlick, R, Greene, Mh, Gross, M, Grossman, Hb, Grubb R., 3rd, Gu, J, Guan, P, Haiman, Ca, Hallmans, G, Hankinson, Se, Harris, Cc, Hartge, P, Hattinger, C, Hayes, Rb, He, Q, Helman, L, Henderson, Be, Henriksson, R, Hoffman Bolton, J, Hohensee, C, Holly, Ea, Hong, Yc, Hoover, Rn, Hosgood HD, 3rd, Hsiao, Cf, Hsing, Aw, Hsiung, Ca, Hu, N, Hu, W, Hu, Z, Huang, M, Hunter, Dj, Inskip, Pd, Ito, H, Jacobs, Ej, Jacobs, Kb, Jenab, M, Ji, Bt, Johansen, C, Johansson, M, Johnson, A, Kaaks, R, Kamat, Am, Kamineni, A, Karagas, M, Khanna, C, Khaw, Kt, Kim, C, Kim, I, Kim, Yh, Kim, Yc, Kim, Yt, Kang, Ch, Jung, Yj, Kitahara, Cm, Klein, Ap, Klein, R, Kogevinas, M, Koh, Wp, Kohno, T, Kolonel, Ln, Kooperberg, C, Kratz, Cp, Krogh, V, Kunitoh, H, Kurtz, Rc, Kurucu, N, Lan, Q, Lathrop, M, Lau, Cc, Lecanda, F, Lee, Km, Lee, Mp, Le Marchand, L, Lerner, Sp, Li, D, Liao, Lm, Lim, Wy, Lin, D, Lin, J, Lindstrom, S, Linet, M, Lissowska, J, Liu, J, Ljungberg, B, Lloreta, J, Lu, D, Ma, J, Malats, N, Mannisto, S, Marina, N, Mastrangelo, G, Matsuo, K, Mcglynn, Ka, McKean Cowdin, R, Mcneill, Lh, Mcwilliams, Rr, Melin, B, Meltzer, P, Mensah, Je, Miao, X, Michaud, D, Mondul, Am, Moore, Le, Muir, K, Niwa, S, Olson, Sh, Orr, N, Panico, Salvatore, Park, Jy, Patel, Av, Patino Garcia, A, Pavanello, S, Peeters, Ph, Peplonska, B, Peters, U, Petersen, Gm, Picci, P, Pike, Mc, Porru, S, Prescott, J, Pu, X, Purdue, Mp, Qiao, Yl, Rajaraman, P, Riboli, E, Risch, Ha, Rodabough, Rj, Rothman, N, Ruder, Am, Ryu, J, Sanson, M, Schned, A, Schumacher, Fr, Schwartz, Ag, Schwartz, Kl, Schwenn, M, Scotlandi, K, Seow, A, Serra, C, Serra, M, Sesso, Hd, Severi, G, Shen, H, Shen, M, Shete, S, Shiraishi, K, Shu, Xo, Siddiq, A, Sierrasesumaga, L, Sierri, S, Loon Sihoe, Ad, Silverman, Dt, Simon, M, Southey, Mc, Spector, L, Spitz, M, Stampfer, M, Stattin, P, Stern, Mc, Stevens, Vl, Stolzenberg Solomon, Rz, Stram, Do, Strom, S, Su, Wc, Sund, M, Sung, Sw, Swerdlow, A, Tan, W, Tanaka, H, Tang, W, Tang, Zz, Tardon, A, Tay, E, Taylor, Pr, Tettey, Y, Thomas, Dm, Tirabosco, R, Tjonneland, A, Tobias, G, Toro, Jr, Travis, Rc, Trichopoulos, D, Troisi, R, Truelove, A, Tsai, Yh, Tucker, Ma, Tumino, R, Van Den Berg, D, Van Den Eeden, Sk, Vermeulen, R, Vineis, P, Visvanathan, K, Vogel, U, Wang, C, Wang, J, Wang, S, Weiderpass, E, Weinstein, Sj, Wentzensen, N, Wheeler, W, White, E, Wiencke, Jk, Wolk, A, Wolpin, Bm, Wong, Mp, Wrensch, M, Wu, C, Wu, T, Wu, X, Wu, Yl, Wunder, J, Xiang, Yb, Xu, J, Yang, Hp, Yang, Pc, Yatabe, Y, Ye, Y, Yeboah, Ed, Yin, Z, Ying, C, Yu, Cj, Yu, K, Yuan, Jm, Zanetti, Ka, Zeleniuch Jacquotte, A, Zheng, W, Zhou, B, Mirabello, L, Savage, Sa, Kraft, P, Chanock, Sj, Yeager, M, Landi, Mt, Shi, J, Chatterjee, N, Amundadottir, Lt, Wang, Z., Zhu, B., Zhang, M., Parikh, H., Jia, J., Chung, C.C., Sampson, J.N., Hoskins, J.W., Hutchinson, A., Burdette, L., Ibrahim, A., Hautman, C., Raj, P.S., Abnet, C.C., Adjei, A.A., Ahlbom, A., Albanes, D., Allen, N.E., Ambrosone, C.B., Aldrich, M., Amiano, P., Amos, C., Andersson, U., Gerald Andriole, G.A., Jr., Andrulis, I.L., Arici, C., Arslan, A.A., Austin, M.A., Baris, D., Barkauskas, D.A., Bassig, B.A., Freeman, L.E.B., Berg, C.D., Berndt, S.I., Bertazzi, P.A., Biritwum, R.B., Black, A., Blot, W., Boeing, H., Boffetta, P., Bolton, K., Boutron-Ruault, M.-C., Bracci, P.M., Brennan, P., Brinton, L.A., Brotzman, M., Bueno-de-Mesquita, H.B., Buring, J.E., Butler, M.A., Cai, Q., Cancel-Tassin, G., Canzian, F., Cao, G., Caporaso, N.E., Carrato, A., Carreon, T., Carta, A., Chang, G.-C., Chang, I.-S., Chang-Claude, J., Che, X., Chen, C.-J., Chen, C.-Y., Chen, C.-H., Chen, C., Chen, K.-Y., Chen, Y.-M., Chokkalingam, A.P., Chu, L.W., Clavel-Chapelon, F., Colditz, G.A., Colt, J.S., Conti, D., Cook, M.B., Cortessis, V.K., Crawford, E.D., Cussenot, O., Davis, F.G., De Vivo, I., Deng, X., Ding, T., Dinney, C.P., Di Stefano, A.L., Diver, W.R., Duell, E.J., Elena, J.W., Fan, J.-H., Feigelson, H.S., Feychting, M., Figueroa, J.D., Flanagan, A.M., Fraumeni, J.F., Jr., Freedman, N.D., Fridley, B.L., Fuchs, C.S., Gago-Dominguez, M., Gallinger, S., Gao, Y.-T., Gapstur, S.M., Garcia-Closas, M., Garcia-Closas, R., Gastier-Foster, J.M., Gaziano, J.M., Gerhard, D.S., Giffen, C.A., Giles, G.G., Gillanders, E.M., Giovannucci, E.L., Goggins, M., Gokgoz, N., Goldstein, A.M., Gonzalez, C., Gorlick, R., Greene, M.H., Gross, M., Grossman, H.B., Grubb, R., III and Gu, J., Guan, P., Haiman, C.A., Hallmans, G., Hankinson, S.E., Harris, C.C., Hartge, P., Hattinger, C., Hayes, R.B., He, Q., Helman, L., Henderson, B.E., Henriksson, R., Hoffman-Bolton, J., Hohensee, C., Holly, E.A., Hong, Y.-C., Hoover, R.N., Dean Hosgood, H., Hsiao, C.-F., Hsing, A.W., Hsiung, C.A., Hu, N., Hu, W., Hu, Z., Huang, M.-S., Hunter, D.J., Inskip, P.D., Ito, H., Jacobs, E.J., Jacobs, K.B., Jenab, M., Ji, B.-T., Johansen, C., Johansson, M., Johnson, A., Kaaks, R., Kamat, A.M., Kamineni, A., Karagas, M., Khanna, C., Khaw, K.-T., Kim, C., Kim, I.-S., Kim, J.H., Kim, Y.H., Kim, Y.-C., Kim, Y.T., Kang, C.H., Jung, Y.J., Kitahara, C.M., Klein, A.P., Klein, R., Kogevinas, M., Koh, W.-P., Kohno, T., Kolonel, L.N., Kooperberg, C., Kratz, C.P., Krogh, V., Kunitoh, H., Kurtz, R.C., Kurucu, N., Lan, Q., Lathrop, M., Lau, C.C., Lecanda, F., Lee, K.-M., Lee, M.P., Marchand, L.L., Lerner, S.P., Li, D., Liao, L.M., Lim, W.-Y., Lin, D., Lin, J., Lindstrom, S., Linet, M.S., Lissowska, J., Liu, J., Ljungberg, B., Lloreta, J., Lu, D., Ma, J., Malats, N., Mannisto, S., Marina, N., Mastrangelo, G., Matsuo, K., McGlynn, K.A., McKean-Cowdin, R., McNeil, L.H., McWilliams, R.R., Melin, B.S., Meltzer, P.S., Mensah, J.E., Miao, X., Michaud, D.S., Mondul, A.M., Moore, L.E., Muir, K., Niwa, S., Olson, S.H., Orr, N., Panico, S., Park, J.Y., Patel, A.V., Patino-Garcia, A., Pavanello, S., Peeters, P.H.M., Peplonska, B., Peters, U., Petersen, G.M., Picci, P., Pike, M.C., Porru, S., Prescott, J., Pu, X., Purdue, M.P., Qiao, Y.-L., Rajaraman, P., Riboli, E., Risch, H.A., Rodabough, R.J., Rothman, N., Ruder, A.M., Ryu, J.-S., Sanson, M., Schned, A., Schumacher, F.R., Schwartz, A.G., Schwartz, K.L., Schwenn, M., Scotlandi, K., Seow, A., Serra, C., Serra, M., Sesso, H.D., Severi, G., Shen, H., Shen, M., Shete, S., Shiraishi, K., Shu, X.-O., Siddiq, A., Sierrasesumaga, L., Sierri, S., Sihoe, A.D.L., Silverman, D.T., Simon, M., Southey, M.C., Spector, L., Spitz, M., Stampfer, M., Stattin, P., Stern, M.C., Stevens, V.L., Stolzenberg-Solomon, R.Z., Stram, D.O., Strom, S.S., Su, W.-C., Sund, M., Sung, S.W., Swerdlow, A., Tan, W., Tanaka, H., Tang, W., Tang, Z.-Z., Tardon, A., Tay, E., Taylor, P.R., Tettey, Y., Thomas, D.M., Tirabosco, R., Tjonneland, A., Tobias, G.S., Toro, J.R., Travis, R.C., Trichopoulos, D., Troisi, R., Truelove, A., Tsai, Y.-H., Tucker, M.A., Tumino, R., Van Den Berg, D., Van Den Eeden, S.K., Vermeulen, R., Vineis, P., Visvanathan, K., Vogel, U., Wang, C., Wang, J., Wang, S.S., Weiderpass, E., Weinstein, S.J., Wentzensen, N., Wheeler, W., White, E., Wiencke, J.K., Wolk, A., Wolpin, B.M., Wong, M.P., Wrensch, M., Wu, C., Wu, T., Wu, X., Wu, Y.-L., Wunder, J.S., Xiang, Y.-B., Xu, J., Yang, H.P., Yang, P.-C., Yatabe, Y., Ye, Y., Yeboah, E.D., Yin, Z., Ying, C., Yu, C.-J., Yu, K., Yuan, J.-M., Zanetti, K.A., Zeleniuch-Jacquotte, A., Zheng, W., Zhou, B., Mirabello, L., Savage, S.A., Kraft, P., Chanock, S.J., Yeager, M., Landi, M.T., Shi, J., Chatterjee, N., and Amundadottir, L.T.

Subjects
Male, SINGLE-NUCLEOTIDE POLYMORPHISM, Genome-wide association study, Epigenesis, Genetic, Gene Frequency, Molecular Biology, Genetics, Genetics (clinical), Neoplasms, Odds Ratio, Genome-wide association studies (GWAS), Telomerase, DNA METHYLATION Author Information, Association Studies Articles, General Medicine, PANCREATIC-CANCER, PROSTATE-CANCER, Neoplasm Proteins, POSTMENOPAUSAL BREAST-CANCER, TERT PROMOTER MUTATIONS, Gene Expression Regulation, Neoplastic, 2 SUSCEPTIBILITY LOCI, DNA methylation, Chromosomes, Human, Pair 5, Female, Risk, Locus (genetics), Single-nucleotide polymorphism, TERT and CLPTM1L gene, Biology, Polymorphism, Single Nucleotide, LUNG-CANCER, Humans, Genetic Predisposition to Disease, GENOME-WIDE ASSOCIATION, Allele, Gene, Allele frequency, Alleles, Genetic association, chromosome 5p15.33, Computational Biology, Membrane Proteins, DNA Methylation, Genetic Loci, TELOMERE LENGTH, Genome-Wide Association Study
Abstract

Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This region harbors the TERT and CLPTM1L genes; the former encodes the catalytic subunit of telomerase reverse transcriptase and the latter may play a role in apoptosis. To investigate further the genetic architecture of common susceptibility alleles in this region, we conducted an agnostic subset-based meta-analysis (association analysis based on subsets) across six distinct cancers in 34 248 cases and 45 036 controls. Based on sequential conditional analysis, we identified as many as six independent risk loci marked by common single-nucleotide polymorphisms: five in the TERT gene (Region 1: rs7726159, P = 2.10 x 10(-39); Region 3: rs2853677, P = 3.30 x 10(-36) and PConditional = 2.36 x 10(-8); Region 4: rs2736098, P = 3.87 x 10(-12) and PConditional = 5.19 x 10(-6), Region 5: rs13172201, P = 0.041 and PConditional = 2.04 x 10(-6); and Region 6: rs10069690, P = 7.49 x 10(-15) and PConditional = 5.35 x 10(-7)) and one in the neighboring CLPTM1L gene (Region 2: rs451360; P = 1.90 x 10(-18) and PConditional = 7.06 x 10(-16)). Between three and five cancers mapped to each independent locus with both risk-enhancing and protective effects. Allele-specific effects on DNA methylation were seen for a subset of risk loci, indicating that methylation and subsequent effects on gene expression may contribute to the biology of risk variants on 5p15.33. Our results provide strong support for extensive pleiotropy across this region of 5p15.33, to an extent not previously observed in other cancer susceptibility loci.

Published
2014

43. A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci

Author

Rajesh Kumar, Gerald L. Andriole, Robert L. Grubb, Monica McGrath, Amanda Black, Manuela Gago-Dominguez, Margaret A. Knowles, Francisco X. Real, Nilanjan Chatterjee, Thorunn Rafnar, Kevin B. Jacobs, Silvia Polidoro, Debra T. Silverman, Sita H. Vermeulen, Manuel Sanchez, Núria Malats, Salvatore Panico, Amy Hutchinson, William Wheeler, Carmen Navarro, Montserrat Garcia-Closas, Carlotta Sacerdote, Gabriel Valdivia, Yi-Ping Fu, Kari Stefansson, Michelle A.T. Hildebrandt, Alessandra Allione, Katja K.H. Aben, Alison Johnson, W. Ryan Diver, Laurie Burdett, Sophia C.E. Bolick, David J. Hunter, Jarmo Virtamo, Jack A. Taylor, Ludmila Prokunina-Olsson, José I Sanz-Velez, Mark P. Purdue, Fulvio Ricceri, Elio Riboli, Maria Teresa Landi, Susan M. Gapstur, Søren Besenbacher, Joseph F. Fraumeni, Olivier Cussenot, J. Alfred Witjes, Victoria K. Cortessis, Paul Brennan, Tony Fletcher, David Van Den Berg, Börje Ljungberg, Lambertus A. Kiemeney, Dalsu Baris, Mark Teo, Zongli Xu, Geraldine Cancel-Tassin, Holger Dietrich, Zhaoming Wang, Maria D. Garcia-Prats, Françoise Clavel-Chapelon, Adonina Tardón, Paolo Vineis, Peter Rudnai, Margaret R. Karagas, Naomi E. Allen, H. Bas Bueno-de-Mesquita, Molly Schwenn, Jose I. Mayordomo, Ashley C. Godfrey, Manolis Kogevinas, Silvia Selinski, Stephen J. Chanock, Jonine D. Figueroa, Alan R. Schned, Stefano Porru, Mariana C. Stern, Demetrius Albanes, Simonetta Guarrera, Patrick Sulem, Immaculata De Vivo, Hushan Yang, Robert N. Hoover, Kvetoslava Koppova, Michael J. Thun, Malcolm C. Pike, Giuseppe Matullo, D T Bishop, Neil E. Caporaso, Klaus Golka, Eugen Gurzau, Colin P.N. Dinney, Josep Lloreta, Nathaniel Rothman, Eric J. Jacobs, Simone Benhamou, Alfredo Carrato, Federico Canzian, Xifeng Wu, Consol Serra, Anne Tjønneland, Jian-Min Yuan, Meredith Yeager, Reina García-Closas, Stephanie J. Weinstein, Jan G. Hengstler, Dimitrios Trichopoulos, Remco R. R. Makkinje, Anne E. Kiltie, Bogdan Czerniak, Meng Chen, Rothman, N, Garcia Closas, M, Chatterjee, N, Malats, N, Wu, X, Figueroa, Jd, Real, Fx, Van Den Berg, D, Matullo, G, Baris, D, Thun, M, Kiemeney, La, Vineis, P, De Vivo, I, Albanes, D, Purdue, Mp, Rafnar, T, Hildebrandt, Ma, Kiltie, Ae, Cussenot, O, Golka, K, Kumar, R, Taylor, Ja, Mayordomo, Ji, Jacobs, Kb, Kogevinas, M, Hutchinson, A, Wang, Z, Fu, Yp, Prokunina Olsson, L, Burdett, L, Yeager, M, Wheeler, W, Tardón, A, Serra, C, Carrato, A, García Closas, R, Lloreta, J, Johnson, A, Schwenn, M, Karagas, Mr, Schned, A, Andriole G., Jr, Grubb R., 3rd, Black, A, Jacobs, Ej, Diver, Wr, Gapstur, Sm, Weinstein, Sj, Virtamo, J, Cortessis, Vk, Gago Dominguez, M, Pike, Mc, Stern, Mc, Yuan, Jm, Hunter, Dj, Mcgrath, M, Dinney, Cp, Czerniak, B, Chen, M, Yang, H, Vermeulen, Sh, Aben, Kk, Witjes, Ja, Makkinje, Rr, Sulem, P, Besenbacher, S, Stefansson, K, Riboli, E, Brennan, P, Panico, Salvatore, Navarro, C, Allen, Ne, Bueno de Mesquita, Hb, Trichopoulos, D, Caporaso, Nicola, Landi, Mt, Canzian, F, Ljungberg, B, Tjonneland, A, Clavel Chapelon, F, Bishop, Dt, Teo, Mt, Knowles, Ma, Guarrera, S, Polidoro, S, Ricceri, F, Sacerdote, C, Allione, A, Cancel Tassin, G, Selinski, S, Hengstler, Jg, Dietrich, H, Fletcher, T, Rudnai, P, Gurzau, E, Koppova, K, Bolick, Sc, Godfrey, A, Xu, Z, Sanz Velez, Ji, D., García Prats M, Sanchez, M, Valdivia, G, Porru, S, Benhamou, S, Hoover, Rn, Fraumeni JF, Jr, Silverman, Dt, and Chanock, Sj

Subjects
Male, Arylamine N-Acetyltransferase, Chromosomes, Human, Pair 22, Genome-wide association study, Aetiology, screening and detection [ONCOL 5], medicine.disease_cause, Genome-wide association studies, Risk Factors, genome-wide association, bladder cancer, Psychology, Genetics, Sex Characteristics, Incidence, Bladder cancer, Smoking, Chromosome Mapping, Single Nucleotide, Tag SNP, Europe, Chromosomes, Human, Pair 2, Pair 2, Female, Human, Locus (genetics), Single-nucleotide polymorphism, Biology, Polymorphism, Single Nucleotide, Risk Assessment, Chromosomes, Article, Molecular epidemiology [NCEBP 1], Translational research [ONCOL 3], medicine, Humans, Family, Genetic Predisposition to Disease, Polymorphism, Pair 18, Pair 22, Genome-Wide Association Study, Neoplasm Staging, Spain, United States, Urinary Bladder Neoplasms, Cancer, Chromosome, medicine.disease, Evaluation of complex medical interventions [NCEBP 2], Carcinogenesis, Chromosomes, Human, Pair 18
Abstract

We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻¹²) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10⁻¹¹) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10⁻⁷) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide associations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10⁻¹¹) and a tag SNP for NAT2 acetylation status (P = 4 × 10⁻¹¹), and found interactions with smoking in both regions. Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis.

Published
2010

44. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types

Author

Yeul Hong Kim, Sonja I. Berndt, José María Huerta, Morgan Rouprêt, Reury Perng Perng, Yi Young Choi, Lindsay M. Morton, Roberto Tirabosco, H. Bas Bueno-de-Mesquita, Wendy Cozen, Neil E. Caporaso, Stephen J. Chanock, Zhenhong Zhao, Dina Halai, Neyssa Marina, Ann L. Oberg, Stephen M. Ansell, Zhibin Hu, Donghui Li, Anne J. Novak, Jenny Turner, Wen Tan, Julie E. Buring, Stefano Porru, Qincheng He, Tania Carreón, Guoping Wu, Graham G. Giles, Claire M. Vajdic, Rudolf Kaaks, Ulrika Andersson, Susan L. Slager, Jen Yu Hung, Luis Sierrasesúmaga, Roel Vermeulen, Louise A. Brinton, Myron D. Gross, Jennifer Prescott, E. Lund, Chih Yi Chen, Jin Eun Choi, Chaoyu Wang, George J. Weiner, H. Dean Hosgood, Haixin Li, Carrie A. Thompson, Núria Malats, James McKay, Stephanie J. Weinstein, Young Tae Kim, Emily White, Pan-Chyr Yang, Orestis A. Panagiotou, Robert J. Klein, Joseph Vijai, Josep Lloreta, Immaculata De Vivo, Sofia Pavanello, Thomas E. Witzig, Montserrat Garcia-Closas, Roger Henriksson, Bryan A. Bassig, Tait D. Shanafelt, Rachel S. Kelly, Joseph M. Connors, Marco Rais, Wu Chou Su, Alex Smith, John J. Spinelli, Julie M. Gastier-Foster, Anne Kricker, In Kyu Park, Marc J. Gunter, Chancellor Hohensee, Simon Crouch, Jarmo Virtamo, M. G. Ennas, Lucia Conde, Lotte Maxild Mortensen, Lenka Foretova, Eric J. Duell, Anthony Staines, Hongyan Chen, Baosen Zhou, Brian M. Wolpin, Simone Benhamou, Zhaoming Wang, Françoise Clavel-Chapelon, Charles C. Chung, Nan Hu, Domenico Palli, Rebecca Montalvan, Thomas M. Habermann, Debra T. Silverman, Preetha Rajaraman, Christian C. Abnet, Wei-Yen Lim, Yuh Min Chen, Michelle Cotterchio, Lucia Miligi, Claudia Maria Hattinger, Eve Roman, Christopher Kim, Federico Canzian, Alan D. L. Sihoe, Sharon A. Savage, Mark P. Purdue, Maria Teresa Landi, Susan M. Gapstur, M Zucca, Yuanqing Ye, Jian Su, Chong-Jen Yu, Edward Giovannucci, Alain Monnereau, Afshan Siddiq, Ralph L. Erickson, Katherine A. McGlynn, Petra H.M. Peeters, W. Ryan Diver, David Van Den Berg, Gloria M. Petersen, Judith Hoffman-Bolton, Xiao-Ou Shu, Ying Chen, Eric J. Jacobs, Heiner Boeing, Sophia S. Wang, Hans-Olov Adami, Yuqing Li, Jacqueline Clavel, Ellen T. Chang, Tongzhang Zheng, William Pao, Hideo Kunitoh, Ulrike Peters, Jenny Chang-Claude, Alexandra Nieters, Silvia de Sanjosé, Chen Wu, Anders Ahlbom, Jun Suk Kim, Fredrick R. Schumacher, Roberta McKean-Cowdin, Laurence N. Kolonel, Herbert Yu, Li Liu, Vittorio Krogh, Tangchun Wu, Ho Il Yoon, Joseph F. Fraumeni, Olivier Cussenot, Jae Sook Sung, Kari E. North, Andrew D. Zelenetz, Ana Patiño-García, Anne Zeleniuch-Jacquotte, Christopher A. Haiman, Biyun Qian, Giovanni Maria Ferri, Rebecca Rodabough, Xifeng Wu, Maria Feychting, Kuan-Yu Chen, Laure Dossus, Jianjun Liu, Jean Wactawski-Wende, Constance Chen, Robert L. Grubb, Paolo Vineis, Mads Melbye, Chien Chung Lin, Malin Sund, Wei Zheng, Jun Xu, Yi Song Chen, Kay-Tee Khaw, Richard K. Severson, Kun-Chieh Chen, Jian-Min Yuan, Bu Tian Ji, Simonetta Di Lollo, Ping Xu, Howard D. Sesso, Yoo Jin Jung, Margaret R. Karagas, Piero Picci, Gianluca Severi, Margaret A. Tucker, Ti Ding, Gee-Chen Chang, Li Hsin Chien, She-Juan An, Maria Pik Wong, Chien-Jen Chen, Jonine D. Figueroa, Sun-Seog Kweon, Katia Scotlandi, Sara H. Olson, Kendra Schwartz, Chang Hyun Kang, Marta Crous-Bou, Yawei Zhang, Ludmila Prokunina-Olsson, Yolanda Benavente, Christine D. Berg, Kala Visvanathan, Loic Le Marchand, Takashi Kohno, Nilanjan Chatterjee, Tracy Lightfoot, Zhihua Yin, Lee E. Moore, Joanne S. Colt, Laurie Burdett, Tetsuya Mitsudomi, Harvey A. Risch, Alfredo Carrato, Hyo Sung Jeon, Victoria L. Stevens, Richard Gorlick, Danylo J. Villano, Alison P. Klein, Angela Brooks-Wilson, Joshua N. Sampson, Chu Chen, You-Lin Qiao, Kouya Shiraishi, Alan R. Schned, Dominique S. Michaud, Peng Guan, Philip R. Taylor, Gerald L. Andriole, John K.C. Chan, Eva Comperat, Randy D. Gascoyne, Marc Maynadie, Kyong Hwa Park, Amanda Black, Charles Kooperberg, Andrea La Croix, Kenneth Offit, Peter Kraft, David Thomas, Manuela Gago-Dominguez, Manolis Kogevinas, Theodore R. Holford, Pamela L. Horn-Ross, Xingzhou He, Massimo Serra, Satu Männistö, Christoffer Johansen, Meredith Yeager, Robert N. Hoover, Mary Ann Butler, William Wheeler, Jian Gu, Wei Wu, Ying Hsiang Chen, Leslie Bernstein, Yao Jen Li, David J. Hunter, In-Jae Oh, Jay S. Wunder, Meng Zhu, Henrik Hjalgrim, Martyn T. Smith, Alisa M. Goldstein, Linda M. Liao, Chao Agnes Hsiung, Ruth C. Travis, Jiucun Wang, Marie-Christine Boutron-Ruault, Daru Lu, Reina García-Closas, Avima M. Ruder, Martha S. Linet, Wei Tang, Geraldine Cancel-Tassin, Brian K. Link, Rebecca D. Jackson, J. Michael Gaziano, Malcolm C. Pike, Yu-Tang Gao, Lisa Mirabello, Alan A. Arslan, Hong Zheng, Nicolas Wentzensen, Chung Hsing Chen, I. Shou Chang, Meir J. Stampfer, Brenda M. Birmann, Alison Johnson, Wong-Ho Chow, Chin-Fu Hsiao, Neal D. Freedman, Robert C. Kurtz, Donald A. Barkauskas, Steven Gallinger, Junwen Wang, Simina M. Boca, Irene L. Andrulis, Hongbing Shen, Adrienne M. Flanagan, Cosmeri Rizzato, Marianna C. Stern, Angela Carta, Melissa C. Southey, Corrado Magnani, Sook Whan Sung, Lesley F. Tinker, M. Dorronsoro, Guangfu Jin, Giovanna Masala, Yi-Long Wu, Min-Ho Shin, Ming Shyan Huang, Göran Hallmans, Xueying Zhao, Jacques Riby, Beatrice Melin, Adonina Tardón, Börje Ljungberg, Mark Liebow, Elizabeth A. Holly, Carol Giffen, Paolo Boffetta, Maria Fernanda Amary, Jihua Li, Mazda Jenab, Keitaro Matsuo, Nalan Gokgoz, Karin E. Smedby, Cari M. Kitahara, Mia M. Gaudet, Cecilia Arici, Brian E. Henderson, Amy Hutchinson, Elio Riboli, Patricia Hartge, Victoria K. Cortessis, Kexin Chen, Dalsu Baris, Michael Goggins, Young-Chul Kim, Tsung-Ying Yang, Fusheng Wei, Peter D. Inskip, Demetrius Albanes, Fang Yu Tsai, Qing Lan, Li Jin, Charles E. Lawrence, Nikolaus Becker, Rachael S. Stolzenberg-Solomon, Bengt Glimelius, Wei Hu, Maria Dolores Chirlaque, Kimberly A. Bertrand, Bruce K. Armstrong, Veronica Wendy Setiawan, Kathy J. Helzlsouer, Manal M. Hassan, Jun Yokota, David V. Conti, Kai Yu, Chenwei Liu, Christine F. Skibola, Jae Yong Park, Fernando Lecanda, Dimitrios Trichopoulos, Eleanor Kane, Dongxin Lin, Yun-Chul Hong, Consol Serra, Anne Tjønneland, Melissa A. Austin, X. Zhang, Charles S. Fuchs, Nathaniel Rothman, Paul Brennan, Chih-Liang Wang, Wei Shen, Ying-Huang Tsai, Hee Nam Kim, Ghislaine Scelo, Faith G. Davis, Sara Lindström, Molly Schwenn, Giuseppe Mastrangelo, Adeline Seow, Laufey T. Amundadottir, Laura E. Beane Freeman, Huan Guo, Victor Ho-Fun Lee, Aruna Kamineni, Pierluigi Cocco, Jiang Chang, Emanuele Angelucci, Paige M. Bracci, Yong-Bing Xiang, G. M. Monawar Hosain, Elisabete Weiderpass, James R. Cerhan, Junjie Wu, Lauren R. Teras, Jin Hee Kim, Qiuyin Cai, Sampson, J.N., Wheeler, W.A., Yeager, M., Panagiotou, O., Wang, Z., Berndt, S.I., Lan, Q., Abnet, C.C., Amundadottir, L.T., Figueroa, J.D., Landi, M.T., Mirabello, L., Savage, S.A., Taylor, P.R., De Vivo, I., McGlynn, K.A., Purdue, M.P., Rajaraman, P., Adami, H.-O., Ahlbom, A., Albanes, D., Amary, M.F., An, S.-J., Andersson, U., Andriole, G., Jr., Andrulis, I.L., Angelucci, E., Ansell, S.M., Arici, C., Armstrong, B.K., Arslan, A.A., Austin, M.A., Baris, D., Barkauskas, D.A., Bassig, B.A., Becker, N., Benavente, Y., Benhamou, S., Berg, C., Van Den Berg, D., Bernstein, L., Bertrand, K.A., Birmann, B.M., Black, A., Boeing, H., Boffetta, P., Boutron-Ruault, M.-C., Bracci, P.M., Brinton, L., Brooks-Wilson, A.R., Bueno-De-Mesquita, H.B., Burdett, L., Buring, J., Butler, M.A., Cai, Q., Cancel-Tassin, G., Canzian, F., Carrato, A., Carreon, T., Carta, A., Chan, J.K.C., Chang, E.T., Chang, G.-C., Chang, I.S., Chang, J., Chang-Claude, J., Chen, C.-J., Chen, C.-Y., Chen, C., Chen, C.-H., Chen, H., Chen, K., Chen, K.-Y., Chen, K.-C., Chen, Y., Chen, Y.-H., Chen, Y.-S., Chen, Y.-M., Chien, L.-H., Chirlaque, M.-D., Choi, J.E., Choi, Y.Y., Chow, W.-H., Chung, C.C., Clavel, J., Clavel-Chapelon, F., Cocco, P., Colt, J.S., Comperat, E., Conde, L., Connors, J.M., Conti, D., Cortessis, V.K., Cotterchio, M., Cozen, W., Crouch, S., Crous-Bou, M., Cussenot, O., Davis, F.G., Ding, T., Diver, W.R., Dorronsoro, M., Dossus, L., Duell, E.J., Ennas, M.G., Erickson, R.L., Feychting, M., Flanagan, A.M., Foretova, L., Fraumeni, J.F., Jr., Freedman, N.D., Freeman, L.E.B., Fuchs, C., Gago-Dominguez, M., Gallinger, S., Gao, Y.-T., Gapstur, S.M., Garcia-Closas, M., García-Closas, R., Gascoyne, R.D., Gastier-Foster, J., Gaudet, M.M., Gaziano, J.M., Giffen, C., Giles, G.G., Giovannucci, E., Glimelius, B., Goggins, M., Gokgoz, N., Goldstein, A.M., Gorlick, R., Gross, M., Grubb, R., III and Gu, J., Guan, P., Gunter, M., Guo, H., Habermann, T.M., Haiman, C.A., Halai, D., Hallmans, G., Hassan, M., Hattinger, C., He, Q., He, X., Helzlsouer, K., Henderson, B., Henriksson, R., Hjalgrim, H., Hoffman-Bolton, J., Hohensee, C., Holford, T.R., Holly, E.A., Hong, Y.-C., Hoover, R.N., Horn-Ross, P.L., Hosain, G.M.M., Hosgood, H.D., III and Hsiao, C.-F., Hu, N., Hu, W., Hu, Z., Huang, M.-S., Huerta, J.-M., Hung, J.-Y., Hutchinson, A., Inskip, P.D., Jackson, R.D., Jacobs, E.J., Jenab, M., Jeon, H.-S., Ji, B.-T., Jin, G., Jin, L., Johansen, C., Johnson, A., Jung, Y.J., Kaaks, R., Kamineni, A., Kane, E., Kang, C.H., Karagas, M.R., Kelly, R.S., Khaw, K.-T., Kim, C., Kim, H.N., Kim, J.H., Kim, J.S., Kim, Y.H., Kim, Y.T., Kim, Y.-C., Kitahara, C.M., Klein, A.P., Klein, R.J., Kogevinas, M., Kohno, T., Kolonel, L.N., Kooperberg, C., Kricker, A., Krogh, V., Kunitoh, H., Kurtz, R.C., Kweon, S.-S., La Croix, A., Lawrence, C., Lecanda, F., Lee, V.H.F., Li, D., Li, H., Li, J., Li, Y.-J., Li, Y., Liao, L.M., Liebow, M., Lightfoot, T., Lim, W.-Y., Lin, C.-C., Lin, D., Lindstrom, S., Linet, M.S., Link, B.K., Liu, C., Liu, J., Liu, L., Ljungberg, B., Lloreta, J., Di Lollo, S., Lu, D., Lund, E., Malats, N., Mannisto, S., Marchand, L.L., Marina, N., Masala, G., Mastrangelo, G., Matsuo, K., Maynadie, M., McKay, J., McKean-Cowdin, R., Melbye, M., Melin, B.S., Michaud, D.S., Mitsudomi, T., Monnereau, A., Montalvan, R., Moore, L.E., Mortensen, L.M., Nieters, A., North, K.E., Novak, A.J., Oberg, A.L., Offit, K., Oh, I.-J., Olson, S.H., Palli, D., Pao, W., Park, I.K., Park, J.Y., Park, K.H., Patiño-Garcia, A., Pavanello, S., Peeters, P.H.M., Perng, R.-P., Peters, U., Petersen, G.M., Picci, P., Pike, M.C., Porru, S., Prescott, J., Prokunina-Olsson, L., Qian, B., Qiao, Y.-L., Rais, M., Riboli, E., Riby, J., Risch, H.A., Rizzato, C., Rodabough, R., Roman, E., Roupret, M., Ruder, A.M., De Sanjose, S., Scelo, G., Schned, A., Schumacher, F., Schwartz, K., Schwenn, M., Scotlandi, K., Seow, A., Serra, C., Serra, M., Sesso, H.D., Setiawan, V.W., Severi, G., Severson, R.K., Shanafelt, T.D., Shen, H., Shen, W., Shin, M.-H., Shiraishi, K., Shu, X.-O., Siddiq, A., Sierrasesúmaga, L., Sihoe, A.D.L., Skibola, C.F., Smith, A., Smith, M.T., Southey, M.C., Spinelli, J.J., Staines, A., Stampfer, M., Stern, M.C., Stevens, V.L., Stolzenberg-Solomon, R.S., Su, J., Su, W.-C., Sund, M., Sung, J.S., Sung, S.W., Tan, W., Tang, W., Tardón, A., Thomas, D., Thompson, C.A., Tinker, L.F., Tirabosco, R., Tjønneland, A., Travis, R.C., Trichopoulos, D., Tsai, F.-Y., Tsai, Y.-H., Tucker, M., Turner, J., Vajdic, C.M., Vermeulen, R.C.H., Villano, D.J., Vineis, P., Virtamo, J., Visvanathan, K., Wactawski-Wende, J., Wang, C., Wang, C.-L., Wang, J.-C., Wang, J., Wei, F., Weiderpass, E., Weiner, G.J., Weinstein, S., Wentzensen, N., White, E., Witzig, T.E., Wolpin, B.M., Wong, M.P., Wu, C., Wu, G., Wu, J., Wu, T., Wu, W., Wu, X., Wu, Y.-L., Wunder, J.S., Xiang, Y.-B., Xu, J., Xu, P., Yang, P.-C., Yang, T.-Y., Ye, Y., Yin, Z., Yokota, J., Yoon, H.-I., Yu, C.-J., Yu, H., Yu, K., Yuan, J.-M., Zelenetz, A., Zeleniuch-Jacquotte, A., Zhang, X.-C., Zhang, Y., Zhao, X., Zhao, Z., Zheng, H., Zheng, T., Zheng, W., Zhou, B., Zhu, M., Zucca, M., Boca, S.M., Cerhan, J.R., Ferri, G.M., Hartge, P., Hsiung, C.A., Magnani, C., Miligi, L., Morton, L.M., Smedby, K.E., Teras, L.R., Vijai, J., Wang, S.S., Brennan, P., Caporaso, N.E., Hunter, D.J., Kraft, P., Rothman, N., Silverman, D.T., Slager, S.L., Chanock, S.J., Chatterjee, N., Infection & Immunity, dIRAS RA-I&I RA, LS IRAS EEPI GRA (Gezh.risico-analyse), and Risk Assessment

Subjects
Male, Cancer Research, Lung Neoplasms, Lymphoma, Genome-wide association study, Polymorphism (computer science), Neoplasms, Medicine, Chronic, Genetics, Osteosarcoma, Oncology And Carcinogenesis, Leukemia, Smoking, Family aggregation, Single Nucleotide, Middle Aged, Familial risk, Diffuse, Kidney Neoplasms, Lymphocytic, Oncology, Adult, Aged, Asian Continental Ancestry Group, Bone Neoplasms, European Continental Ancestry Group, Female, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large B-Cell, Diffuse, Polymorphism, Single Nucleotide, Testicular Neoplasms, Tissue Array Analysis, Urinary Bladder Neoplasms, Genetic Predisposition to Disease, Genome-Wide Association Study, Genetic correlation, Large B-Cell, Oncology & Carcinogenesis, Polymorphism, business.industry, Extramural, B-Cell, Cancer, Heritability, Genome-wide association studies for thirteen cancer types, medicine.disease, business
Abstract

BACKGROUND: Studies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites.METHODS: Between 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cancers, and the genetic correlation between pairs of cancers.RESULTS: GWAS heritability was statistically significant at nearly all sites, with the estimates of array-based heritability, hl (2), on the liability threshold (LT) scale ranging from 0.05 to 0.38. Estimating the combined heritability of multiple smoking characteristics, we calculate that at least 24% (95% confidence interval [CI] = 14% to 37%) and 7% (95% CI = 4% to 11%) of the heritability for lung and bladder cancer, respectively, can be attributed to genetic determinants of smoking. Most pairs of cancers studied did not show evidence of strong genetic correlation. We found only four pairs of cancers with marginally statistically significant correlations, specifically kidney and testes (ρ = 0.73, SE = 0.28), diffuse large B-cell lymphoma (DLBCL) and pediatric osteosarcoma (ρ = 0.53, SE = 0.21), DLBCL and chronic lymphocytic leukemia (CLL) (ρ = 0.51, SE =0.18), and bladder and lung (ρ = 0.35, SE = 0.14). Correlation analysis also indicates that the genetic architecture of lung cancer differs between a smoking population of European ancestry and a nonsmoking Asian population, allowing for the possibility that the genetic etiology for the same disease can vary by population and environmental exposures.CONCLUSION: Our results provide important insights into the genetic architecture of cancers and suggest new avenues for investigation.

Published
2015

45. Modeling Historic Arsenic Exposures and Spatial Risk for Bladder Cancer.

Author

Boyle J, Ward MH, Koutros S, Karagas MR, Schwenn M, Johnson AT, Silverman DT, and Wheeler DC

Abstract

Arsenic is a bladder carcinogen though less is known regarding the specific temporal relationship between exposure and bladder cancer diagnosis. In this study, we modeled time-varying mixtures of arsenic exposures at many historic temporal windows to evaluate their association with bladder cancer risk in the New England Bladder Cancer Study. We used arsenic exposure estimates up to 60 years prior to study entry and compared the goodness of fit of models using these mixtures to those using summary measures of arsenic exposures. We used the Bayesian index low rank kriging multiple membership model (LRK-MMM) to estimate the associations of these mixtures with bladder cancer and estimate cumulative spatial risk for bladder cancer using participants' residential histories. We found consistent evidence that modeling arsenic exposures as a time-varying mixture provided better fit to the data than using a single arsenic exposure summary measure. We estimated several positive though not significant associations of the time-varying arsenic mixtures with bladder cancer having odds ratios (ORs) of 1.03-1.14 and identified many significant and positive associations for an interaction among those who consumed water from a private dug well (ORs 1.28-1.60). Arsenic exposures 40-50 years before study entry received elevated importance weights in these mixtures. Additionally, we found two small areas of elevated cumulative spatial risk for bladder cancer in southern New Hampshire and in south central Maine. These results emphasize the importance of considering time-varying mixtures of exposures for diseases with long latencies such as bladder cancer.

Published
2024
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46. Occupational exposure to organic solvents and risk of bladder cancer.

Author

Xie S, Friesen MC, Baris D, Schwenn M, Rothman N, Johnson A, Karagas MR, Silverman DT, and Koutros S

Subjects
Humans, Male, Middle Aged, Female, Adult, Case-Control Studies, Aged, Risk Factors, Occupational Diseases chemically induced, Occupational Diseases epidemiology, Odds Ratio, Logistic Models, Urinary Bladder Neoplasms chemically induced, Urinary Bladder Neoplasms epidemiology, Occupational Exposure adverse effects, Solvents adverse effects, Toluene adverse effects, Xylenes, Benzene
Abstract

Background: Bladder cancer has been linked to several occupations that involve the use of solvents, including those used in the dry-cleaning industry., Objectives: We evaluated exposure to solvents and risk of bladder cancer in 1182 incident cases and 1408 controls from a population-based study., Methods: Exposure to solvents was quantitatively assessed using a job-exposure matrix (CANJEM). Exposure to benzene, toluene and xylene often co-occur. Therefore, we created two additional sets of metrics for combined benzene, toluene and xylene (BTX) exposure: (1) CANJEM-based BTX metrics and (2) hybrid BTX metrics, using an approach that integrates the CANJEM-based BTX metrics together with lifetime occupational histories and exposure-oriented modules that captured within-job, respondent-specific details about tasks and chemicals. Adjusted odds ratios (ORs) and 95% confidence intervals (95% CI) were estimated using logistic regression., Results: Bladder cancer risks were increased among those ever exposed to benzene (OR = 1.63, 95% CI: 1.14-2.32), toluene (OR = 1.60, 95% CI: 1.06-2.43), and xylene (OR = 1.67, 95% CI: 1.13-2.48) individually. We further observed a statistically significant exposure-response relationship for cumulative BTX exposure, with a stronger association using the hybrid BTX metrics (OR Q1vsUnexposed  = 1.26, 95% CI: 0.83-1.90; OR Q2vsUnexposed  = 1.52, 95% CI: 1.00-2.31; OR Q3vsUnexposed  = 1.88, 95% CI: 1.24-2.85; and OR Q4vsUnexposed  = 2.23, 95% CI: 1.35-3.69) (p-trend=0.001) than using CANJEM-based metrics (p-trend=0.02)., Impact: There is limited evidence about the role of exposure to specific organic solvents, alone or in combination on the risk of developing bladder cancer. In this study, workers with increasing exposure to benzene, toluene, and xylene as a group (BTX) had a statistically significant exposure-response relationship with bladder cancer. Future evaluation of the carcinogenicity of BTX and other organic solvents, particularly concurrent exposure, on bladder cancer development is needed., (© 2024. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)

Published
2024
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47. Urinary mutagenicity and bladder cancer risk in northern New England.

Author

Wong JYY, Fischer AH, Baris D, Beane Freeman LE, Karagas MR, Schwenn M, Johnson A, Matthews PP, Swank AE, Hosain GM, Koutros S, Silverman DT, DeMarini DM, and Rothman N

Subjects
Humans, Urinary Bladder, Case-Control Studies, New England epidemiology, Carcinogens, Mutagenicity Tests, Mutagens toxicity, Urinary Bladder Neoplasms chemically induced, Urinary Bladder Neoplasms epidemiology, Urinary Bladder Neoplasms genetics
Abstract

The etiology of bladder cancer among never smokers without occupational or environmental exposure to established urothelial carcinogens remains unclear. Urinary mutagenicity is an integrative measure that reflects recent exposure to genotoxic agents. Here, we investigated its potential association with bladder cancer in rural northern New England. We analyzed 156 bladder cancer cases and 247 cancer-free controls from a large population-based case-control study conducted in Maine, New Hampshire, and Vermont. Overnight urine samples were deconjugated enzymatically and the extracted organics were assessed for mutagenicity using the plate-incorporation Ames assay with the Salmonella frameshift strain YG1041 + S9. Logistic regression was used to estimate the odds ratios (OR) and 95% confidence intervals (CI) of bladder cancer in relation to having mutagenic versus nonmutagenic urine, adjusted for age, sex, and state, and stratified by smoking status (never, former, and current). We found evidence for an association between having mutagenic urine and increased bladder cancer risk among never smokers (OR = 3.8, 95% CI: 1.3-11.2) but not among former or current smokers. Risk could not be estimated among current smokers because nearly all cases and controls had mutagenic urine. Urinary mutagenicity among never-smoking controls could not be explained by recent exposure to established occupational and environmental mutagenic bladder carcinogens evaluated in our study. Our findings suggest that among never smokers, urinary mutagenicity potentially reflects genotoxic exposure profiles relevant to bladder carcinogenesis. Future studies are needed to replicate our findings and identify compounds and their sources that influence bladder cancer risk., (© 2024 The Authors. Environmental and Molecular Mutagenesis published by Wiley Periodicals LLC on behalf of Environmental Mutagenesis and Genomics Society. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.)

Published
2024
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48. Analysis of Several Common APOBEC-type Mutations in Bladder Tumors Suggests Links to Viral Infection.

Author

Rao N, Starrett GJ, Piaskowski ML, Butler KE, Golubeva Y, Yan W, Lawrence SM, Dean M, Garcia-Closas M, Baris D, Johnson A, Schwenn M, Malats N, Real FX, Kogevinas M, Rothman N, Silverman DT, Dyrskjøt L, Buck CB, Koutros S, and Prokunina-Olsson L

Subjects
Humans, Mutation, Urinary Bladder pathology, Class I Phosphatidylinositol 3-Kinases genetics, Urinary Bladder Neoplasms genetics, Urinary Bladder Neoplasms pathology, Virus Diseases
Abstract

FGFR3 and PIK3CA are among the most frequently mutated genes in bladder tumors. We hypothesized that recurrent mutations in these genes might be caused by common carcinogenic exposures such as smoking and other factors. We analyzed 2,816 bladder tumors with available data on FGFR3 and/or PIK3CA mutations, focusing on the most recurrent mutations detected in ≥10% of tumors. Compared to tumors with other FGFR3/PIK3CA mutations, FGFR3-Y375C was more common in tumors from smokers than never-smokers (P = 0.009), while several APOBEC-type driver mutations were enriched in never-smokers: FGFR3-S249C (P = 0.013) and PIK3CA-E542K/PIK3CA-E545K (P = 0.009). To explore possible causes of these APOBEC-type mutations, we analyzed RNA sequencing (RNA-seq) data from 798 bladder tumors and detected several viruses, with BK polyomavirus (BKPyV) being the most common. We then performed IHC staining for polyomavirus (PyV) Large T-antigen (LTAg) in an independent set of 211 bladder tumors. Overall, by RNA-seq or IHC-LTAg, we detected PyV in 26 out of 1,010 bladder tumors with significantly higher detection (P = 4.4 × 10-5), 25 of 554 (4.5%) in non-muscle-invasive bladder cancers (NMIBC) versus 1 of 456 (0.2%) of muscle-invasive bladder cancers (MIBC). In the NMIBC subset, the FGFR3/PIK3CA APOBEC-type driver mutations were detected in 94.7% (18/19) of PyV-positive versus 68.3% (259/379) of PyV-negative tumors (P = 0.011). BKPyV tumor positivity in the NMIBC subset with FGFR3- or PIK3CA-mutated tumors was also associated with a higher risk of progression to MIBC (P = 0.019). In conclusion, our results support smoking and BKPyV infection as risk factors contributing to bladder tumorigenesis in the general patient population through distinct molecular mechanisms., Prevention Relevance: Tobacco smoking likely causes one of the most common mutations in bladder tumors (FGFR3-Y375C), while viral infections might contribute to three others (FGFR3-S249C, PIK3CA-E542K, and PIK3CA-E545K). Understanding the causes of these mutations may lead to new prevention and treatment strategies, such as viral screening and vaccination., (©2023 American Association for Cancer Research.)

Published
2023
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49. Urine pH and Risk of Bladder Cancer in Northern New England.

Author

Fischer AH, Wong JYY, Baris D, Koutros S, Karagas MR, Schwenn M, Johnson A, Alguacil J, Silverman DT, and Rothman N

Subjects
Humans, Case-Control Studies, New England epidemiology, Amines, Hydrogen-Ion Concentration, Risk Factors, Urinary Bladder Neoplasms epidemiology, Urinary Bladder Neoplasms etiology, Urinary Bladder Neoplasms urine, Carcinoma, Transitional Cell
Abstract

Background: Acidic urine pH is associated with rapid hydrolysis of N-glucuronide conjugates of aromatic amines into metabolites that may undergo metabolism in the bladder lumen to form mutagenic DNA adducts. We previously reported that consistently acidic urine was associated with increased bladder cancer risk in a hospital-based case-control study in Spain. Here, we conducted a separate study in northern New England to replicate these findings., Methods: In a large, population-based case-control study conducted in Maine, New Hampshire, and Vermont, we examined bladder cancer risk in relation to consistent urine pH, measured twice daily by participants over 4 consecutive days using dipsticks. In parallel, we collected spot urine samples and conducted laboratory measurements of urinary acidity using a pH meter. Unconditional logistic regression was used to estimate associations, adjusting for age, gender, race, Hispanic status, and state. Analyses were further stratified by smoking status., Results: Among 616 urothelial carcinoma cases and 897 controls, urine pH consistently ≤ 6.0 was associated with increased bladder cancer risk (OR = 1.27; 95% confidence interval, 1.02-1.57), with the effect limited to ever-smokers. These findings were supported by analyses of a spot urine, with statistically significant exposure-response relationships for bladder cancer risk overall (Ptrend = 5.1×10-3) and among ever-smokers (Ptrend = 1.2×10-3)., Conclusions: Consistent with a previous study in Spain, our findings suggest that acidic urine pH is associated with increased bladder cancer risk., Impact: Our findings align with experimental results showing that acidic urine pH, which is partly modifiable by lifestyle factors, is linked to hydrolysis of acid-labile conjugates of carcinogenic aromatic amines., (©2023 American Association for Cancer Research.)

Published
2023
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50. Nitrated Polycyclic Aromatic Hydrocarbon (Nitro-PAH) Signatures and Somatic Mutations in Diesel Exhaust-Exposed Bladder Tumors.

Author

Gonzalez N, Rao N, Dean M, Lee D, Hurson AN, Baris D, Schwenn M, Johnson A, Prokunina-Olsson L, Friesen MC, Zhu B, Rothman N, Silverman DT, and Koutros S

Subjects
Humans, Vehicle Emissions toxicity, Nitrates, Mutation, Carcinogenesis, Polycyclic Aromatic Hydrocarbons toxicity, Urinary Bladder Neoplasms chemically induced, Urinary Bladder Neoplasms epidemiology, Urinary Bladder Neoplasms genetics
Abstract

Background: Diesel exhaust is a complex mixture, including polycyclic aromatic hydrocarbons (PAH) and nitrated PAHs (nitro-PAH), many of which are potent mutagens and possible bladder carcinogens. To explore the association between diesel exposure and bladder carcinogenesis, we examined the relationship between exposure and somatic mutations and mutational signatures in bladder tumors., Methods: Targeted sequencing was conducted in bladder tumors from the New England Bladder Cancer Study. Using data on 797 cases and 1,418 controls, two-stage polytomous logistic regression was used to evaluate etiologic heterogeneity between bladder cancer subtypes and quantitative, lifetime estimates of respirable elemental carbon (REC), a surrogate for diesel exposure. Poisson regression was used to evaluate associations between REC and mutational signatures., Results: We observed significant heterogeneity in the diesel-bladder cancer risk relationship, with a strong positive association among cases with high-grade, nonmuscle invasive TP53-mutated tumors compared with controls [ORTop Tertile vs.Unexposed, 4.8; 95% confidence interval (CI), 2.2-10.5; Ptrend < 0.001; Pheterogeneity = 0.002]. In muscle-invasive tumors, we observed a positive association between diesel exposure and the nitro-PAH signatures of 1,6-dintropyrene (RR, 1.93; 95% CI, 1.28-2.92) and 3-nitrobenzoic acid (RR, 1.97; 95% CI, 1.33-2.92)., Conclusions: The relationship between diesel exhaust and bladder cancer was heterogeneous based on the presence of TP53 mutations in tumors, further supporting the link between PAH exposure and TP53 mutations in carcinogenesis. Future studies that can identify nitro-PAH signatures in exposed tumors are warranted to add human data supporting the link between diesel and bladder cancer., Impact: This study provides additional insight into the etiology and possible mechanisms related to diesel exhaust-induced bladder cancer., (©2023 American Association for Cancer Research.)

Published
2023
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