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398 results on '"Schwarzenbach, Heidi"'

5. Implementing liquid biopsies into clinical decision making for cancer immunotherapy.

Author

Quandt, Dagmar, Dieter Zucht, Hans, Amann, Arno, Wulf-Goldenberg, Anne, Borrebaeck, Carl, Cannarile, Michael, Lambrechts, Diether, Oberacher, Herbert, Garrett, James, Nayak, Tapan, Kazinski, Michael, Massie, Charles, Schwarzenbach, Heidi, Maio, Michele, Prins, Robert, Wendik, Björn, Hockett, Richard, Enderle, Daniel, Noerholm, Mikkel, Hendriks, Hans, Zwierzina, Heinz, and Seliger, Barbara

Subjects
biomarker, high throughput analysis, immunotherapy, liquid biopsy, tumor, Animals, Biomarkers, Tumor, Clinical Decision-Making, Diagnostic Imaging, Humans, Immunotherapy, Liquid Biopsy, Neoplasms
Abstract

During the last decade, novel immunotherapeutic strategies, in particular antibodies directed against immune checkpoint inhibitors, have revolutionized the treatment of different malignancies leading to an improved survival of patients. Identification of immune-related biomarkers for diagnosis, prognosis, monitoring of immune responses and selection of patients for specific cancer immunotherapies is urgently required and therefore areas of intensive research. Easily accessible samples in particular liquid biopsies (body fluids), such as blood, saliva or urine, are preferred for serial tumor biopsies.Although monitoring of immune and tumor responses prior, during and post immunotherapy has led to significant advances of patients outcome, valid and stable prognostic biomarkers are still missing. This might be due to the limited capacity of the technologies employed, reproducibility of results as well as assay stability and validation of results. Therefore solid approaches to assess immune regulation and modulation as well as to follow up the nature of the tumor in liquid biopsies are urgently required to discover valuable and relevant biomarkers including sample preparation, timing of the collection and the type of liquid samples. This article summarizes our knowledge of the well-known liquid material in a new context as liquid biopsy and focuses on collection and assay requirements for the analysis and the technical developments that allow the implementation of different high-throughput assays to detect alterations at the genetic and immunologic level, which could be used for monitoring treatment efficiency, acquired therapy resistance mechanisms and the prognostic value of the liquid biopsies.

Published
2017

6. Interplay of microRNAs and circRNAs in Epithelial Ovarian Cancer.

Author

Schwarzenbach, Heidi

Subjects
*COMPETITIVE endogenous RNA, *OVARIAN epithelial cancer, *NON-coding RNA, *GENE expression, *OVARIAN cancer, *CIRCULAR RNA
Abstract

Epithelial ovarian cancer (EOC) with its high death incidence rate is generally detected at advanced stages. During its progression, EOC often develops peritoneal metastasis aggravating the outcomes of EOC patients. Studies on non-coding RNAs (ncRNAs), such as microRNAs (miRNAs) and circular RNAs (circRNAs), have analyzed the impact of miRNAs and circRNAs, along with their interaction among each other, on cancer cells. MiRNAs can act as oncogenes or tumor suppressors modulating post-transcriptional gene expression. There is accumulating evidence that circRNAs apply their stable, covalently closed, continuous circular structures to competitively inhibit miRNA function, and so act as competing endogenous RNAs (ceRNAs). This interplay between both ncRNAs participates in the malignity of a variety of cancer types, including EOC. In the current review, I describe the characteristics of miRNAs and circRNAs, and discuss their interplay with each other in the development, progression, and drug resistance of EOC. Sponging of miRNAs by circRNAs may be used as a biomarker and therapeutic target in EOC. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Specific microRNA signatures in exosomes of triple-negative and HER2-positive breast cancer patients undergoing neoadjuvant therapy within the GeparSixto trial

Author

Stevic, Ines, Müller, Volkmar, Weber, Karsten, Fasching, Peter A., Karn, Thomas, Marmé, Frederic, Schem, Christian, Stickeler, Elmar, Denkert, Carsten, van Mackelenbergh, Marion, Salat, Christoph, Schneeweiss, Andreas, Pantel, Klaus, Loibl, Sibylle, Untch, Michael, and Schwarzenbach, Heidi

Published
2018
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33. Diagnosis, monitoring and prevention of exposure-related non-communicable diseases in the living and working environment: DiMoPEx-project is designed to determine the impacts of environmental exposure on human health

Author

Budnik, Lygia Therese, Adam, Balazs, Albin, Maria, Banelli, Barbara, Baur, Xaver, Belpoggi, Fiorella, Bolognesi, Claudia, Broberg, Karin, Gustavsson, Per, Göen, Thomas, Fischer, Axel, Jarosinska, Dorota, Manservisi, Fabiana, O’Kennedy, Richard, Øvrevik, Johan, Paunovic, Elizabet, Ritz, Beate, Scheepers, Paul T. J., Schlünssen, Vivi, Schwarzenbach, Heidi, Schwarze, Per E., Sheils, Orla, Sigsgaard, Torben, Van Damme, Karel, and Casteleyn, Ludwine

Published
2018
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