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1. Allogeneic mesenchymal stem cell therapy with laromestrocel in mild Alzheimer’s disease: a randomized controlled phase 2a trial

Author

Rash, Brian G., Ramdas, Kevin N., Agafonova, Nataliya, Naioti, Eric, McClain-Moss, Lisa, Zainul, Zarin, Varnado, Brittany, Peterson, Kevin, Brown, Michael, Leal, Thiago, Kopcho, Steven, Carballosa, Raul, Patel, Paayal, Brody, Mark, Herskowitz, Brad, Fuquay, Ana, Rodriguez, Savannah, Jacobson, Alan F., Leon, Ramon, Pfeffer, Michael, Schwartzbard, Julie B., Botbyl, Jeffrey, Oliva, Jr, Anthony A., and Hare, Joshua M.

Published
2025
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3. Safety and efficacy of continuous subcutaneous levodopa–carbidopa infusion (ND0612) for Parkinson's disease with motor fluctuations (BouNDless): a phase 3, randomised, double-blind, double-dummy, multicentre trial

Author

Afshari, Mitra, Amelin, Alexander, Arkadir, David, Badarny, Samih, Balaguer Martinez, Ernest, Bogucki, Andrzej, Boyd, James, Buyan Dent, Laura, Carroll, Camille, Chaudhuri, Kallol Ray, Cooney, Jeffrey, Corbillé, Anne-Gaëlle, Danaila, Teodor, De Pandis, Maria Francesca, Dethy, Sophie, Dhall, Rohit, Djaldetti, Ruth, Durif, Franck, Flitman, Stephen, Freire Alvarez, Eric, Goudreau, John, Grandas Perez, Francisco, Gurevich, Tanya, Isa, Arnaldo, Juncos, Jorge L, Kanchana, Sulada, Klodowska-Duda, Gabriela, Koziorowski, Dariusz, Kulisevsky Bojarski, Jaime, Lopez Lozano, Juan, Luo, Lan, Lytvynenko, Nataliya, Marconi, Roberto, Marques, Ana-Raquel, Martinez Castrillo, Juan Carlos, Martinez Torres, Irene, Mentreddi, Aashoo, Mir Rivera, Pablo, Moskovko, Sergii, Neryanova, Yuliya, Onofrj, Marco, Ostrem, Jill, Pacchetti, Claudio, Pavese, Nicola, Pellicano, Clelia, Revuelta, Gonzalo, Rodrigues, Ana Margarida, Rodriguez, Ramon, Rudzinska, Monika, Sarwar, Nighat, Schwartzbard, Julie, Scorr, Laura, Slevin, John, Slobodin, Tatyana, Spalletta, Gianfranco, Tagliati, Michele, Tai, Yen, Tessitore, Alessandro, Valkovic, Peter, Verhagen, Leo, Vostrikova, Elena, Yahalom, Gilad, Zalyalova, Zuleykha, Zarubova, Katerina, Zhukova, Irina, Espay, Alberto J, Stocchi, Fabrizio, Pahwa, Rajesh, Albanese, Alberto, Ellenbogen, Aaron, Ferreira, Joaquim J, Giladi, Nir, Hassin-Baer, Sharon, Hernandez-Vara, Jorge, Isaacson, Stuart H, Kieburtz, Karl, LeWitt, Peter A, Lopez-Manzanares, Lydia, Olanow, C Warren, Poewe, Werner, Sarva, Harini, Yardeni, Tami, Adar, Liat, Salin, Laurence, Lopes, Nelson, Sasson, Nissim, Case, Ryan, and Rascol, Olivier

Published
2024
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6. Hoehn and Yahr Stage and Striatal Dat-SPECT Uptake Are Predictors of Parkinson’s Disease Motor Progression

Author

Holly Jackson, Judith Anzures-Cabrera, Kirsten I. Taylor, Gennaro Pagano, PASADENA Investigators, Prasinezumab Study Group, Claudia Altendorf, Chareyna Anandan, Giulia Andrews, Solène Ansquer, Raphaele Arrouasse, Sana Aslam, Jean-Philippe Azulay, Jeanette Baker, Ernest Balaguer Martinez, Shadi Barbu, Kara Bardram, Danny Bega, Helena Bejr-Kasem Marco, Isabelle Benatru, Eve Benchetrit, Felix Bernhard, Amir Besharat, Sagari Bette, Amelie Bichon, Andrew Billnitzer, Sophie Blondeau, Thomas Boraud, Freiderike Borngräber, James Boyd, Kathrin Brockmann, Matthew Brodsky, Ethan Brown, Christof Bruecke, Fabienne Calvas, Monica Canelo, Federico Carbone, Claire Carroll, Laura Casado Fernandez, Catherine Cassé-Perrot, Anna Castrioto, Helene Catala, Justine Chan, Samia Cheriet, Anthony Ciabarra, Joseph Classen, Juliana Coleman, Robert Coleman, Yaroslau Compta, Anne-Gaëlle Corbillé, Jean-Christophe Corvol, Mariana Cosgaya, Nabila Dahodwala, Philippe Damier, Elodie David, Thomas Davis, Marissa Dean, Berengere Debilly, Janell DeGiorgio, Andres Deik, Laure Delaby, Marie-Helene Delfini, Pascal Derkinderen, Philipp Derost, Maria de Toledo, Lisa Deuel, Ann Marie Diaz-Hernandez, Cameron Dietiker, Karina Dimenshteyn, Julio Dotor, Franck Durif, Jens Ebentheuer, Karla Maria Eggert, Sara Eichau Madueño, Claudia Eickhoff, Aaron Ellenbogen, Philipp Ellmerer, Ines Esparragosa Vazquez, Alexandre Eusebio, Siobhan Ewert, John Fang, Danielle Feigenbaum, Frederique Fluchere, Alexandra Foubert-Samier, Marie Fournier, Anne Fradet, Valerie Fraix, Samuel Frank, Franca Fries, Monique Galitzky, Marisol Gallardó Pérez, Jose Manuel García Moreno, Carmen Gasca, Thomas Gasser, Joyce Gibbons, Caroline Giordana, Alicia Gonzalez Martinez, Ira Goodman, Arantza Gorospe, Marie Goubeaud, David Grabli, Mangone Graziella, Stephan Grimaldi, Jeffrey Gross, Raquel Guimaraes-Costa, Andreas Hartmann, Christian Hartmann, Travis Hassell, Robert Hauser, Antonio Hernandez, Jorge Hernandez-Vara, Guenter Hoeglinger, Christian Homedes, Andrea Horta-Barba, Jean-Luc Houeto, Julius Huebl, Jennifer Hui, Stuart Isaacson, Joseph Jankovic, Annette Janzen, Junior Jauregui, Jocelyne Jiao, Maria Jose Marti Domenech, Xavier Joseph, Srinath Kadimi, Pat Kaminski, Silja Kannenberg, Jan Kassubek, Maya Katz, Kevin Klos, Shannon Klos, Christopher Kobet, Jennifer Koebert, Patricia Krause, Andrea Kuehn, Jaime Kulisevsky Bojarsky, Rajeev Kumar, Martin Kunz, Lille Kurvits, Kimberly Kwei, Simon Laganiere, Brice Laurens, Johannes Levin, Oren Levy, Peter LeWitt, Gurutz Linazasoro Cristóbal, Irene Litvan, Karlo Lizarraga, Katherine Longardner, Rocio Lopez, Lydia Lopez Manzanares, Sara Lucas del Pozo, Maria Rosario Luquin Puido, Nijee Luthra, Kelly Lyons, Sylvia Maass, Gerrit Machetanz, Yolanda Macias, David Maltete, Jorge Uriel Manez Miro, Louise-Laure Mariani, Juan Marin, Kathrin Marini, Ana Marques, Gloria Marti, Saul Martinez, Wassilios Meissner, Sara Meoni, Brit Mollenhauer, Dunia Mon Martinez, Johnson Moon, Elena Moro, Peter Morrison, Christoph Muehlberg, Manpreet Multani, Christine Murphy, Anthony Nicholas, Rajesh Pahwa, Antonio Palasi, Heidi Pape, Neepa Patel, Prity Patel, Marina Peball, Elizabeth Peckham, Terry Peery, Rafael Perez, Jesus Perez, Alisa Petit, Elmar Pinkhardt, Werner Poewe, Elsa Pomies, Cecile Preterre, Joseph Quinn, Olivier Rascol, Philippe Remy, Irene Richard, Benjamin Roeben, Emily Ruether, Jost-Julian Rumpf, David Russell, Hayet Salhi, Daniela Samaniego-Toro, Alexandra Samier-Foubert, Antonio Sanchez, Emmanuelle Schmitt, Alfons Schnitzler, Oliver Schorr, Julie Schwartzbard, Kerstin Schweyer, Klaus Seppi, Victoria Sergo, Holly Shill, Andrew Siderowf, Tanya Simuni, Umberto Spampinato, Ashok Sriram, Natividad Stover, Caroline Tanner, Arjun Tarakad, Carolyn Taylor, Claire Thalamus, Thomas Toothaker, Nadege Van Blercom, Nora Vanegas-Arrogave, Lydia Vela, Sylvian Vergnet, Tiphaine Vidal, Jonathan Vöglein, Ryan Walsh, Cheryl Waters, Mirko Wegscheider, Endy Weidinger, Caroline Weill, Gregor Wenzel, Tatiana Witjas, Isabel Wurster, Brenton Wright, Milan Zimmermann, Rafael Zuzuarregui, Markus Abt, Atieh Bamdadian, Teresa Barata, Nicholas Barbet, Sara Belli, Frank Boess, Azad Bonni, Edilio Borroni, Anne Boulay, Markus Britschgi, Jerome Chague, Valerie Cosson, Christian Czech, Dennis Deptula, Cheikh Diack, Rachelle Doody, Juergen Dukart, Giulia D’Urso, Sebastian Dziadek, Hannah Eddleston, Chris Edgar, Laurent Essioux, Morgan Farell, Rebecca Finch, Paulo Fontoura, Waltraud Gruenbauer, Andrea Hahn, Stefan Holiga, Michael Honer, Shirin Jadidi, Kelly Johnson-Wood, Markus Keller, Timothy Kilchenmann, Martin Koller, Thomas Kremer, Thomas Kustermann, Claire Landsdall, Michael Lindemann, Florian Lipsmeier, Cecile Luzy, Marianne Manchester, Maddalena Marchesi, Ferenc Martenyi, Meret Martin-Facklam, Katerina Mironova, Annabelle Monnet, Emma Moore, Daniel K Ness, Markus Niggli, Tania Nikolcheva, Susanne Ostrowitzki GP, Benedicte Passmard, Agnes Poirier, Anke Post, Megana Prasad, Nathalie Pross, Tiffany Quock, Benedicte Ricci, Ellen Rose, Christoph Sarry, Christine Schubert, Dennis Selkoe, Jeff Sevigny, Kaycee Sink, Hannah Staunton, Tim Steven, Alexander Strasak, Hanno Svoboda KT, Radhika Tripuraneni, Dylan Trundell, Daniel Umbricht, Lynne Verselis, Annamarie Vogt, Ekaterina Volkova-Volkmar, Cornelia Weber, Silke Weber, and Wagner Zago

Subjects
PASADENA, PPMI (Parkinson’s Progression Markers Initiative), Parkinson’s disease, progression predictors, ridge regression, disease stage, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Currently, no treatments available for Parkinson’s disease (PD) can slow PD progression. At the early stage of the disease, only a subset of individuals with PD progress quickly, while the majority have a slowly progressive form of the disease. In developing treatments that aim to slow PD progression, clinical trials aim to include individuals who are likely to progress faster, such that a treatment effect, if one exists, can be identified easier and earlier. The aim of the present study was to identify baseline predictors of clinical progression in early PD. We analyzed 12-month data acquired from the PASADENA trial Part 1 (NCT03100149, n = 76 participants who were allocated to the placebo arm and did not start symptomatic therapy) and the Parkinson’s Progression Markers Initiative (PPMI) study (n = 139 demographically and clinically matched participants). By using ridge regression models including clinical characteristics, imaging, and non-imaging biomarkers, we found that Hoehn and Yahr stage and dopamine transporter single-photon emission computed tomography specific binding ratios (Dat-SPECT SBR) in putamen ipsilateral to the side of motor symptom onset predicted PD progression at the early stage of the disease. Further studies are needed to confirm the validity of these predictors to identify with high accuracy individuals with early PD with a faster progression phenotype.

Published
2021
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7. A Phase II Study to Evaluate the Safety and Efficacy of Prasinezumab in Early Parkinson's Disease (PASADENA): Rationale, Design, and Baseline Data

Author

Gennaro Pagano, Frank G. Boess, Kirsten I. Taylor, Benedicte Ricci, Brit Mollenhauer, Werner Poewe, Anne Boulay, Judith Anzures-Cabrera, Annamarie Vogt, Maddalena Marchesi, Anke Post, Tania Nikolcheva, Gene G. Kinney, Wagner M. Zago, Daniel K. Ness, Hanno Svoboda, Markus Britschgi, Susanne Ostrowitzki, Tanya Simuni, Kenneth Marek, Martin Koller, Jeff Sevigny, Rachelle Doody, Paulo Fontoura, Daniel Umbricht, Azad Bonni, PASADENA Investigators, Prasinezumab Study Group, Claudia Altendorf, Chareyna Anandan, Giulia Andrews, Solène Ansquer, Raphaele Arrouasse, Sana Aslam, Jean-Philippe Azulay, Jeanette Baker, Ernest Balaguer Martinez, Shadi Barbu, Kara Bardram, Danny Bega, Helena Bejr-Kasem Marco, Isabelle Benatru, Eve Benchetrit, Felix Bernhard, Amir Besharat, Sagari Bette, Amelie Bichon, Andrew Billnitzer, Sophie Blondeau, Thomas Boraud, Freiderike Borngräber, James Boyd, Kathrin Brockmann, Matthew Brodsky, Ethan Brown, Christof Bruecke, Fabienne Calvas, Monica Canelo, Federico Carbone, Claire Carroll, Laura Casado Fernandez, Catherine Cassé-Perrot, Anna Castrioto, Helene Catala, Justine Chan, Samia Cheriet, Anthony Ciabarra, Joseph Classen, Juliana Coleman, Robert Coleman, Yaroslau Compta, Anne-Gaëlle Corbillé, Jean-Christophe Corvol, Mariana Cosgaya, Nabila Dahodwala, Philippe Damier, Elodie David, Thomas Davis, Marissa Dean, Berengere Debilly, Janell DeGiorgio, Andres Deik, Laure Delaby, Marie-Helene Delfini, Pascal Derkinderen, Philipp Derost, Maria de Toledo, Lisa Deuel, Ann Marie Diaz-Hernandez, Cameron Dietiker, Karina Dimenshteyn, Julio Dotor, Franck Durif, Jens Ebentheuer, Karla Maria Eggert, Sara Eichau Madueño, Claudia Eickhoff, Aaron Ellenbogen, Philipp Ellmerer, Ines Esparragosa Vazquez, Alexandre Eusebio, Siobhan Ewert, John Fang, Danielle Feigenbaum, Frederique Fluchere, Alexandra Foubert-Samier, Marie Fournier, Anne Fradet, Valerie Fraix, Samuel Frank, Franca Fries, Monique Galitzky, Marisol Gallardó Pérez, Jose Manuel García Moreno, Carmen Gasca, Thomas Gasser, Joyce Gibbons, Caroline Giordana, Alicia Gonzalez Martinez, Ira Goodman, Arantza Gorospe, Marie Goubeaud, David Grabli, Mangone Graziella, Stephan Grimaldi, Jeffrey Gross, Raquel Guimaraes-Costa, Andreas Hartmann, Christian Hartmann, Travis Hassell, Robert Hauser, Antonio Hernandez, Jorge Hernandez-Vara, Günter Höglinger, Christian Homedes, Andrea Horta-Barba, Jean-Luc Houeto, Julius Huebl, Jennifer Hui, Stuart Isaacson, Joseph Jankovic, Annette Janzen, Junior Jauregui, Jocelyne Jiao, Maria Jose Marti Domenech, Xavier Joseph, Srinath Kadimi, Pat Kaminski, Silja Kannenberg, Jan Kassubek, Maya Katz, Kevin Klos, Shannon Klos, Christopher Kobet, Jennifer Koebert, Patricia Krause, Andrea Kuehn, Jaime Kulisevsky Bojarsky, Rajeev Kumar, Martin Kunz, Lille Kurvits, Kimberly Kwei, Simon Laganiere, Brice Laurens, Johannes Levin, Oren Levy, Peter LeWitt, Gurutz Linazasoro Cristóbal, Irene Litvan, Karlo Lizarraga, Katherine Longardner, Rocio Lopez, Lydia Lopez Manzanares, Sara Lucas del Pozo, Maria Rosario Luquin Puido, Nijee Luthra, Kelly Lyons, Sylvia Maass, Gerrit Machetanz, Yolanda Macias, David Maltete, Jorge Uriel Manez Miro, Louise-Laure Mariani, Juan Marin, Kathrin Marini, Ana Marques, Gloria Marti, Saul Martinez, Wassilios Meissner, Sara Meoni, Dunia Mon Martinez, Johnson Moon, Elena Moro, Peter Morrison, Christoph Muehlberg, Manpreet Multani, Christine Murphy, Anthony Nicholas, Rajesh Pahwa, Antonio Palasi, Heidi Pape, Neepa Patel, Prity Patel, Marina Peball, Elizabeth Peckham, Terry Peery, Rafael Perez, Jesus Perez, Alisa Petit, Elmar Pinkhardt, Elsa Pomies, Cecile Preterre, Joseph Quinn, Olivier Rascol, Philippe Remy, Irene Richard, Benjamin Roeben, Emily Ruether, Jost-Julian Rumpf, David Russell, Hayet Salhi, Daniela Samaniego-Toro, Alexandra Samier-Foubert, Antonio Sanchez, Emmanuelle Schmitt, Alfons Schnitzler, Oliver Schorr, Julie Schwartzbard, Kerstin Schweyer, Klaus Seppi, Victoria Sergo, Holly Shill, Andrew Siderowf, Umberto Spampinato, Ashok Sriram, Natividad Stover, Caroline Tanner, Arjun Tarakad, Carolyn Taylor, Claire Thalamus, Thomas Toothaker, Nadege Van Blercom, Nora Vanegas-Arrogave, Lydia Vela, Sylvian Vergnet, Tiphaine Vidal, Jonathan Vöglein, Ryan Walsh, Cheryl Waters, Mirko Wegscheider, Endy Weidinger, Caroline Weill, Gregor Wenzel, Tatiana Witjas, Isabel Wurster, Brenton Wright, Milan Zimmermann, Rafael Zuzuarregui, Markus Abt, Atieh Bamdadian, Teresa Barata, Nicholas Barbet, Sara Belli, Frank Boess, Edilio Borroni, Jerome Chague, Valerie Cosson, Christian Czech, Dennis Deptula, Cheikh Diack, Juergen Dukart, Giulia D'Urso, Sebastian Dziadek, Hannah Eddleston, Chris Edgar, Laurent Essioux, Morgan Farell, Rebecca Finch, Waltraud Gruenbauer, Andrea Hahn, Stefan Holiga, Michael Honer, Shirin Jadidi, Kelly Johnson-Wood, Markus Keller, Timothy Kilchenmann, Thomas Kremer, Thomas Kustermann, Claire Landsdall, Michael Lindemann, Florian Lipsmeier, Cecile Luzy, Marianne Manchester, Ferenc Martenyi, Meret Martin-Facklam, Katerina Mironova, Annabelle Monnet, Emma Moore, Daniel K Ness, Markus Niggli, Benedicte Passmard, Agnes Poirier, Megana Prasad, Nathalie Pross, Tiffany Quock, Ellen Rose, Christoph Sarry, Christine Schubert, Dennis Selkoe, Kaycee Sink, Hannah Staunton, Tim Steven, Alexander Strasak, Kirsten Taylor, Radhika Tripuraneni, Dylan Trundell, Lynne Verselis, Ekaterina Volkova-Volkmar, Cornelia Weber, Silke Weber, and Wagner Zago

Subjects
Parkinson's disease, alpha-synuclein (α-syn), prasinezumab, monoclonal antibodies, disease progression, MDS-UPDRS = Movement Disorder Society—Unified Parkinson's Disease Rating Scale, Neurology. Diseases of the nervous system, RC346-429
Abstract

Background: Currently available treatments for Parkinson's disease (PD) do not slow clinical progression nor target alpha-synuclein, a key protein associated with the disease.Objective: The study objective was to evaluate the efficacy and safety of prasinezumab, a humanized monoclonal antibody that binds aggregated alpha-synuclein, in individuals with early PD.Methods: The PASADENA study is a multicenter, randomized, double-blind, placebo-controlled treatment study. Individuals with early PD, recruited across the US and Europe, received monthly intravenous doses of prasinezumab (1,500 or 4,500 mg) or placebo for a 52-week period (Part 1), followed by a 52-week extension (Part 2) in which all participants received active treatment. Key inclusion criteria were: aged 40–80 years; Hoehn & Yahr (H&Y) Stage I or II; time from diagnosis ≤2 years; having bradykinesia plus one other cardinal sign of PD (e.g., resting tremor, rigidity); DAT-SPECT imaging consistent with PD; and either treatment naïve or on a stable monoamine oxidase B (MAO-B) inhibitor dose. Study design assumptions for sample size and study duration were built using a patient cohort from the Parkinson's Progression Marker Initiative (PPMI). In this report, baseline characteristics are compared between the treatment-naïve and MAO-B inhibitor-treated PASADENA cohorts and between the PASADENA and PPMI populations.Results: Of the 443 patients screened, 316 were enrolled into the PASADENA study between June 2017 and November 2018, with an average age of 59.9 years and 67.4% being male. Mean time from diagnosis at baseline was 10.11 months, with 75.3% in H&Y Stage II. Baseline motor and non-motor symptoms (assessed using Movement Disorder Society—Unified Parkinson's Disease Rating Scale [MDS-UPDRS]) were similar in severity between the MAO-B inhibitor-treated and treatment-naïve PASADENA cohorts (MDS-UPDRS sum of Parts I + II + III [standard deviation (SD)]; 30.21 [11.96], 32.10 [13.20], respectively). The overall PASADENA population (63.6% treatment naïve and 36.4% on MAO-B inhibitor) showed a similar severity in MDS-UPDRS scores (e.g., MDS-UPDRS sum of Parts I + II + III [SD]; 31.41 [12.78], 32.63 [13.04], respectively) to the PPMI cohort (all treatment naïve).Conclusions: The PASADENA study population is suitable to investigate the potential of prasinezumab to slow disease progression in individuals with early PD.Trial Registration: NCT03100149.

Published
2021
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8. Safety and efficacy of continuous subcutaneous levodopa–carbidopa infusion (ND0612) for Parkinson's disease with motor fluctuations (BouNDless): a phase 3, randomised, double-blind, double-dummy, multicentre trial

Author

Espay, Alberto J, primary, Stocchi, Fabrizio, additional, Pahwa, Rajesh, additional, Albanese, Alberto, additional, Ellenbogen, Aaron, additional, Ferreira, Joaquim J, additional, Giladi, Nir, additional, Gurevich, Tanya, additional, Hassin-Baer, Sharon, additional, Hernandez-Vara, Jorge, additional, Isaacson, Stuart H, additional, Kieburtz, Karl, additional, LeWitt, Peter A, additional, Lopez-Manzanares, Lydia, additional, Olanow, C Warren, additional, Poewe, Werner, additional, Sarva, Harini, additional, Yardeni, Tami, additional, Adar, Liat, additional, Salin, Laurence, additional, Lopes, Nelson, additional, Sasson, Nissim, additional, Case, Ryan, additional, Rascol, Olivier, additional, Afshari, Mitra, additional, Amelin, Alexander, additional, Arkadir, David, additional, Badarny, Samih, additional, Balaguer Martinez, Ernest, additional, Bogucki, Andrzej, additional, Boyd, James, additional, Buyan Dent, Laura, additional, Carroll, Camille, additional, Chaudhuri, Kallol Ray, additional, Cooney, Jeffrey, additional, Corbillé, Anne-Gaëlle, additional, Danaila, Teodor, additional, De Pandis, Maria Francesca, additional, Dethy, Sophie, additional, Dhall, Rohit, additional, Djaldetti, Ruth, additional, Durif, Franck, additional, Flitman, Stephen, additional, Freire Alvarez, Eric, additional, Goudreau, John, additional, Grandas Perez, Francisco, additional, Isa, Arnaldo, additional, Juncos, Jorge L, additional, Kanchana, Sulada, additional, Klodowska-Duda, Gabriela, additional, Koziorowski, Dariusz, additional, Kulisevsky Bojarski, Jaime, additional, Lopez Lozano, Juan, additional, Luo, Lan, additional, Lytvynenko, Nataliya, additional, Marconi, Roberto, additional, Marques, Ana-Raquel, additional, Martinez Castrillo, Juan Carlos, additional, Martinez Torres, Irene, additional, Mentreddi, Aashoo, additional, Mir Rivera, Pablo, additional, Moskovko, Sergii, additional, Neryanova, Yuliya, additional, Onofrj, Marco, additional, Ostrem, Jill, additional, Pacchetti, Claudio, additional, Pavese, Nicola, additional, Pellicano, Clelia, additional, Revuelta, Gonzalo, additional, Rodrigues, Ana Margarida, additional, Rodriguez, Ramon, additional, Rudzinska, Monika, additional, Sarwar, Nighat, additional, Schwartzbard, Julie, additional, Scorr, Laura, additional, Slevin, John, additional, Slobodin, Tatyana, additional, Spalletta, Gianfranco, additional, Tagliati, Michele, additional, Tai, Yen, additional, Tessitore, Alessandro, additional, Valkovic, Peter, additional, Verhagen, Leo, additional, Vostrikova, Elena, additional, Yahalom, Gilad, additional, Zalyalova, Zuleykha, additional, Zarubova, Katerina, additional, and Zhukova, Irina, additional

Published
2024
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9. The Impact of an Electronic Best Practice Advisory on Patients' Physical Activity and Cardiovascular Risk Profile.

Author

McCarthy, Margaret M., Szerencsy, Adam, Fletcher, Jason, Taza-Rocano, Leslie, Weintraub, Howard, Hopkins, Stephanie, Applebaum, Robert, Schwartzbard, Arthur, Mann, Devin, D'Eramo Melkus, Gail, Vorderstrasse, Allison, and Katz, Stuart D.

Subjects
CARDIOVASCULAR disease prevention, PATIENT education, RISK assessment, PATIENT compliance, HUMAN services programs, EXERCISE, T-test (Statistics), RESEARCH funding, CLINICAL decision support systems, PILOT projects, CARDIOVASCULAR diseases risk factors, WEARABLE technology, DESCRIPTIVE statistics, HEALTH surveys, HEALTH behavior, ELECTRONIC health records, HEALTH promotion, DATA analysis software, PHYSICAL activity
Abstract

Background: Regular physical activity (PA) is a component of cardiovascular health and is associated with a lower risk of cardiovascular disease (CVD). However, only about half of US adults achieved the current PA recommendations. Objective: The study purpose was to implement PA counseling using a clinical decision support tool in a preventive cardiology clinic and to assess changes in CVD risk factors in a sample of patients enrolled over 12 weeks of PA monitoring. Methods: This intervention, piloted for 1 year, had 3 components embedded in the electronic health record: assessment of patients' PA, an electronic prompt for providers to counsel patients reporting low PA, and patient monitoring using a Fitbit. Cardiovascular disease risk factors included PA (self-report and Fitbit), body mass index, blood pressure, lipids, and cardiorespiratory fitness assessed with the 6-minute walk test. Depression and quality of life were also assessed. Paired t tests assessed changes in CVD risk. Results: The sample who enrolled in the remote patient monitoring (n = 59) were primarily female (51%), White adults (76%) with a mean age of 61.13 ± 11.6 years. Self-reported PA significantly improved over 12 weeks ( P = .005), but not Fitbit steps ( P = .07). There was a significant improvement in cardiorespiratory fitness (469 ± 108 vs 494 ± 132 m, P = .0034), and 23 participants (42%) improved at least 25 m, signifying a clinically meaningful improvement. Only 4 participants were lost to follow-up over 12 weeks of monitoring. Conclusions: Patients may need more frequent reminders to be active after an initial counseling session, perhaps getting automated messages based on their step counts syncing to their electronic health record. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Apheleia‐001: A novel prescreening study designed to enrich and accelerate Alzheimer’s disease clinical trials by efficiently identifying trial‐eligible participants determined to have a high probability of study inclusion, including amyloid positivity

Author

Smith, Katy, primary, Bork, Jason, additional, Jolkovski, Allison, additional, Schillinger, Rona, additional, Batchuluun, Dawn, additional, Ng, Amanda, additional, Brown, Christina M., additional, Kraus, Lori, additional, Matilla, Inmaculada, additional, Bernard, Emmanuel G., additional, Hollingshead, Sarah, additional, Florian, Hana, additional, Yu Lynch, Shau, additional, Lee, Christa, additional, Bannon, Anthony W., additional, McGeeney, Danielle, additional, and Schwartzbard, Julie, additional

Published
2023
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24. Icosapent Ethyl Reduces Ischemic Events in Patients With a History of Previous Coronary Artery Bypass Grafting: REDUCE-IT CABG

Author

Subodh Verma, Deepak L. Bhatt, Ph. Gabriel Steg, Michael Miller, Eliot A. Brinton, Terry A. Jacobson, Nitish K. Dhingra, Steven B. Ketchum, Rebecca A. Juliano, Lixia Jiao, Ralph T. Doyle, Craig Granowitz, C. Michael Gibson, Duane Pinto, Robert P. Giugliano, Matthew J. Budoff, R. Preston Mason, Jean-Claude Tardif, Christie M. Ballantyne, Fabrice M.A.C. Martens, Astrid Schut, Brian Olshansky, Mina Chung, Al Hallstrom, Lesly Pearce, Cyrus Mehta, Rajat Mukherjee, Anjan K. Chakrabarti, Eli V. Gelfand, Megan Carroll Leary, Duane S. Pinto, Yuri B. Pride, Steven Ketchum, Ramakrishna Bhavanthula, Gertrude Chester, Christina Copland, Katelyn Diffin, Ralph Doyle, Kurt Erz, Alex Giaquinto, Paula Glanton, Angela Granger, Richard H. Iroudayassamy, Rebecca Juliano, James Jin, Dimitry Klevak, Hardik Panchal, Robert Wang, Shin-Ru Wang, Gerard Abate, Peggy J. Berry, Rene Braeckman, Declan Doogan, Anne Elson, Amy HauptmannBaker, Isabel Lamela, Catherine Lubeck, Mehar Manku, Sabina Murphy, Monica Sanford, William Stirtan, Paresh Soni, Arnaud Bastien, Demetria Foster, Evangelito Gascon, Judith Johnson, Lasbert Latona, Gang Liu, Sandra Palleja, Nelly Sanjuan, Jimmy Shi, William Stager, Mukund Venkatakrishnan, Ahmed Youssef-Agha, Julie Zhu, Leela Aertker, Suresh Ankolekar, Lisa Goldberg, Natasa Rajicic, Jianfen Shu, Heng Zou, Magdy Mikhail, Gamil Dawood, N. Mathew Koshy, Sandip K. Mukherjee, Rafik Abadier, Andrea L. Lawless, William P. McGuinn, Howard Weintraub, Kathryn Rohr, Edmund Claxton, Robert J. Weiss, Terry D. Klein, Mani Nallasivan, Stephen Crowley, Marilyn King, Anthony D. Alfieri, David Fitz-Patrick, Irving Loh, Nolan J. Mayer, Rakesh Prashad, Samuel Lederman, Debra Weinstein, Harold E. Bays, Keith Chu, Alireza Maghsoudi, Paul D. Thompson, Jeff Carstens, Anna Chang, Kenneth R. Cohen, Julius Dean, Howard S. Ellison, Bernard Erickson, Enrique A. Flores, Daniel W. Gottlieb, Paul Grena, John R. Guyton, Peter H. Jones, John M. Joseph, Norman E. Lepor, Sam Lerman, Robert D. Matheney, Theodore R. Pacheco, Michael B. Russo, John Rubino, Edward S. Pereira, Albert A. Seals, Eduardo Viera, Alan D. Steljes, Jason Thompson, Shaival Kapadia, Michael McIvor, Jorge E. Salazar, Jose O. Santiago, Ralph Vicari, Martin R. Berk, William A. Kaye, Marcus McKenzie, David Podlecki, Brian D. Snyder, Stephen Nash, David M. Herrington, Wallace Johnson, Joseph R. Lee, Ronald Blonder, Alpa M. Patel, Ramon Castello, Susan Greco, Dean J. Kereiakes, Venkatesh K. Nadar, Mark Nathan, Ranganatha P. Potu, Robert Sangrigoli, Richard Smalling, Mitchell Davis, Robert Braastad, James McCriskin, Kunal Bodiwala, Joe L. Hargrove, Mark W. Graves, George Emlein, Raegan W. Durant, James W. Clower, Rohit Arora, Narendra Singh, Lisa Warsinger Martin, W Herbert Haught, Marc P. Litt, Michael D. Klein, Peter Hoagland, Michael Goldstein, Marco S. Mazzella, Daniel H. Dunker, Brian H. Kahn, Carlos S. Ince, Frank A. McGrew, Jay Lee, David Pan, Salman A. Khan, Uri Elkayam, Wasim Deeb, Anne C. Goldberg, Christopher S. Brown, Wayne N. Leimbach, Thomas S. Backer, David R. Sutton, Joel Gellman, Anu R. George, Alan S. Hoffman, Mark Kates, Kishlay Anand, Robert Bear, Brendan J. Cavanaugh, Ramon G. Reyes, Rodolfo Sotolongo, Kenneth Sabatino, Kevin Gallagher, Ehab Sorial, Chris Geohas, Kathleen E. Magness, Bernard P. Grunstra, Frederik A. Martin, William S. Knapp, Mel E. Lucas, John J. Champlin, Jason Demattia, Patrick H. Peters, Judith Kirstein, William J. Randall, Cezar S. Staniloae, Jennifer G. Robinson, Alexander Adler, Christopher Case, Andrew J. Kaplan, Gregory F. Lakin, Krishan K. Goyle, Michael J. DiGiovanna, Chester L. Fisher, Michael Lillestol, Michael Robinson, Robert G. Perry, Lawrence S. Levinson, Brian G. Everhart, Robert D. Madder, Earl F. Martin, Earl E. Martin, Imtiaz Alam, Jose Mari L. Elacion, Robina Poonawala, Taddese T. Desta, Jerome A. Robinson, Gilbert J. Martinez, Jakkidi S. Reddy, Jeffrey D. Wayne, Samuel Mujica Trenche, Westbrook I. Kaplan, Rubin H. Saavedra, Michael D. DiGregorio, Barry D. Bertolet, Neil J. Fraser, Terence T. Hart, Ronald J. Graf, David A. Jasper, Michael Dunn, Dan A. Streja, David J. Strobl, Nan Jiang, Vicki Kalen, Richard Mascolo, Mercedes B. Samson, Michael Stephens, Bret M. Bellard, Mario Juarez, Patrick J. McCarthy, John B. Checton, Michael Stillabower, Edward Goldenberg, Amin H. Karim, Naseem Jaffrani, Robert C. Touchon, Erich R. Fruehling, Clayton J. Friesen, Pradipta Chaudhuri, Frank H. Morris, Robert E. Broker, Rajesh J. Patel, Susan Hole, Randall P. Miller, Francisco G. Miranda, Sadia Dar, Shawn N. Gentry, Paul Hermany, Charles B. Treasure, Miguel E. Trevino, Raimundo Acosta, Anthony Japour, Samuel J. Durr, Thomas Wang, Om P. Ganda, Perry Krichmar, James L. Arter, Douglas Jacoby, Michael A. Schwartz, Amer Al-Karadsheh, Nelson E. Gencheff, John A. Pasquini, Richard Dunbar, Sarah Kohnstamm, Hector F. Lozano, Francine K. Welty, Thomas L. Pitts, Brian Zehnder, Salah El Hafi, Mark A. King, Arnold Ghitis, Marwan M. Bahu, Hooman Ranjbaran Jahromi, Ronald P. Caputo, Robert S. Busch, Michael D. Shapiro, Suhail Zavaro, Munib Daudjee, Shahram Jacobs, Vipul B. Shah, Frank Rubalcava, Mohsin T. Alhaddad, Henry Lui, Raj T. Rajan, Fadi E. Saba, Mahendra Pai N Gunapooti, Tshiswaka B. Kayembe, Timothy Jennings, Robert A. Strzinek, Michael H. Shanik, Pradeep K. Singh, Alastair C. Kennedy, Howard Rubenstein, Ramin Manshadi, Joanne Ladner, Lily Kakish, Ashley Kakish, Amy L. Little, Jaime Gerber, Nancy J. Hinchion, Janet Guarino, Denise Raychok, Susan Budzinski, Kathleen Kelley-Garvin, April Beckord, Jessica Schlinder, Arthur Schwartzbard, Stanley Cobos, Deborah Freeman, David Abisalih, Dervilla McCann, Kylie Guy, Jennifer Chase, Stacey Samuelson, Madeline Cassidy, Marissa Tardif, Jaime Smith, Brenna Sprout, Nanette Riedeman, Julie Goza, Lori Johnson, Chad Kraske, Sheila Hastings, Chris Dutka, Stephanie Smith, Toni McCabe, Kathleen Maloney, Paul Alfieri, Vinay Hosemane, Chanhsamone Syravanh, Cindy Pau, April Limcoiloc, Tabitha Carreira, Taryn S. Kurosawa, Razmig Krumian, Krista Preston, Ashraf Nashed, Daria Schneidman-Fernandez, Jack Patterson, John Tsakonas, Jennifer Esaki, Lynn Sprafka, Porous Patel, Brian Mitchell, Erin M. Ross, Donna Miller, Akash Prashad, Kristina M. Feyler, Natasha Juarbe, Sandra Herrera, Sarah M. Keiran, Becky Whitehead, Whitney Asher, Coury Hobbs, Abbey Elie, Jean Brooks, Amanda L. Zaleski, Brenda Foxen, Barb Lapke, Philippa Wright, Bristol Pavol, Gwen Carangi, Marla Turner, Katharine W. Sanders, Rikita S. Delamar, Virginia L. Wilson, Sarah M. Harvel, Alison M. Cartledge, Kaitlyn R. Bailey, Kathleen Mahon, Timothy Schuchard, Jen Humbert, Mark C. Hanson, Michael P. Cecil, James S. Abraham, Lorie Benedict, Claudia Slayton, Curtis S. Burnett, Rachel W. Ono-Lim, Sharon Budzinski, Shubi A. Khan, Sharon Goss, Terry Techmanski, Farida Valliani, Rimla Joseph, Edith Flores, Laurn Contreras, Ana Aguillon, Carrie-Ann Silvia, Maria Martin, Edmund K. Kerut, Leslie W. Levenson, Louis B. Glade, Brian J. Cospolich, Maureen W. Stein, Stephen P. LaGuardia, Thelma L. Sonza, Tracy M. Fife, Melissa Forschler, Jasmyne Watts, Judy Fritsch, Emese Futchko, Sarah Utech, Scott B. Baker, Miguel F. Roura, Scott A. Segel, James S. Magee, Cathy Jackson, Rebecca F. Goldfaden, Liudmila Quas, Elizabeth C. Ortiz, Michael Simpson, Robert Foster, Christopher Brian, James Trimm, Michael Bailey, Brian Snoddy, Van Reeder, Rachel Wilkinson, Harold Settle, Cynthia Massey, Angela Maiola, Michele Hall, Shelly Hall, Wanda Hall, Mark Xenakis, Janet Barrett, Giovanni Campanile, David Anthou, Susan F. Neill, Steven Karas, Enrique Polanco, Norberto Schechtman, Grace Tischner, Kay Warren, Cynthia St Cyr, Menna Kuczinski, Latrina Alexander, Maricruz Ibarra, Barry S. Horowitz, Jaime Steinsapir, Jeanette Mangual-Coughlin, Brittany Mooney, Precilia Vasquez, Kathleen Rodkey, Alexandria Biberstein, Christine Ignacio, Irina Robinson, Marcia Hibberd, Lisa B. Hoffman, Daniel J. Murak, Raghupathy Varavenkataraman, Theresa M. Ohlson Elliott, Linda A. Cunningham, Heather L. Palmerton, Sheri Poole, Jeannine Moore, Helene Wallace, Ted Chandler, Robert Riley, Farah Dawood, Amir Azeem, Michael Cammarata, Ashleigh Owen, Shivani Aggarwal, Waqas Qureshi, Mohamed Almahmoud, Abdullahi Oseni, Adam Leigh, Erin Barnes, Adam Pflum, Amer Aladin, Karen Blinson, Vickie Wayne, Lynda Doomy, Michele Wall, Valerie Bitterman, Cindi Young, Rachel Grice, Lioubov Poliakova, Jorge Davalos, David Rosenbaum, Mark Boulware, Heather Mazzola, J. Russell Strader, Russell Linsky, David Schwartz, Elizabeth Graf, Alicia Gneiting, Melissa Palmblad, Ashley Donlin, Emily Ensminger, Hillary Garcia, Dawn Robinson, Carolyn Tran, Jeffrey Jacqmein, Darlene Bartilucci, Michael Koren, Barbara Maluchnik, Melissa Parks, Jennifer Miller, Cynthia DeFosse, Albert B. Knouse, Amy Delancey, Stephanie Chin, Thomas Stephens, Mag Sohal, Juana Ingram, Swarooparani Kumar, Heather Foley, Nina Smith, Vera McKinney, Linda Schwarz, Judith Moore, Hildreth Vernon Anderson, Stefano Sdringola-Maranga, Ali Denktas, Elizabeth Turrentine, Rhonda Patterson, John Marshall, Terri Tolar, Donna Patrick, Pamela Schwartzkopf, Anthony M. Fletcher, Frances R. Harris, Sherry Clements, Tiffany Brown, William Smith, Stacey J. Baehl, Robin Fluty, Daniel VanHamersveld, Dennis Breen, Nancy Bender, Beverly Stafford, Tamika Washington, Margaret N. Pike, Mark A. Stich, Evyan Jawad, Amin Nadeem, Jill Nyland, Rhonda Hamer, Kendra Calhoun, Charlotte Mall, Samuel Cadogan, Kati Raynes, Richard Katz, Lorraine Marshall, Rashida Abbas, Jay L. Dinerman, John T. Hartley, Beth Lamb, Lisa Eskridge, Donna Raymond, Kristy Clemmer, Denise M. Fine, Paula Beardsley, Janet Werner, Bette Mahan, Courtney VanTol, Robert Herman, Christine Raiser-Vignola, Felicia McShan, Stefanie A. Neill, David R. Blick, Michael J. Liston, Denetta K. Nelson, Sandra K. Dorrell, Patricia Wyman, Ambereen Quraishi, Fernando Ferro, Frank Morris, Vicki J. Coombs, Autumn M. Mains, Austin A. Campbell, Jeanne Phelps, Cheryl A. Geary, Ellen G. Sheridan, Jean M. Downing, Arie Swatkowski, Tish Redden, Brian Dragutsky, Susan Thomas, Candace Mitchell, Diana Barker, Elanie Turcotte, Deborah Segerson, Jill Guy, Karena De La Mora, Jennifer Hong, Dennis Do, Rose Norris, Faisal Khan, Hector Montero, Stacy Kelly-White, Alan Cleland, Rosalyn Alcalde-Crawford, Melissa Morgan, Brijmohan Sarabu, Megan Minor, Shweta Kamat, Stephanie M. Estes, Nancee Harless, Alicia Disney, Jodi L. Pagano, Chad M. Alford, Noel W. Bedwell, Warren D. Hardy, Kevin DeAndrade, Jessica G. Elmore, Eric Auerbach, Anthony W. Haney, Miriam H. Brooks, Jose Torres, Lois Roper, Terry Backer, Katie Backer, John G. Evans, Ricardo A. Silva, Lorraine H. Dajani, Veronica Yousif, Tammy Ross, Sion K. Roy, Ronald Oudiz, Sajad Hamal, Ferdinand Flores, Amor Leahy, Debra Ayer, Swapna George, Chrisi Carine Stewart, Elvira Orellana, Cristina Boccalandro, Mary Rangel, Suzanne Hennings, Carl Vanselow, Teri Victor, Darlene Birdwell, Paul Haas, Anthony Sandoval, Gina Ciavarella, Caroline Saglam, Amy Bird, Keith Beck, Brian Poliquin, David Dominguez, Brittany Tenorio, Harvonya Perkins, Esther San Roman, Paris Bransford, Christy Lowrance, Marcy Broussard, Mary Ellis, Bobbi Skiles, Jessica Hamilton, Kathryn Hall, Diego Olvera, Julee A. Hartwell, Nevien Sorial, Mary Rickman, Kevin Berman, Nirav Mehta, Annie Laborin, Rodger Rothenberger, Sarah Beauvilliers, Kathy Morrell, Michael P. Schachter, Cindy L. Perkins, Elizabeth A. Gordon, Jennifer Lauer, Kim Bichsel, Kelly Oliver, Leslie J. Mellor, Candice Demattia, Jennifer Schomburg, Yenniffer Moreno, Eduardo Mansur-Garza, Lena Rippstein, Lorie Chacon, Andrea Pena, Michelle King, Susan Richardson, Annette Jessop, Nicole Tucker, Whitney Royer, Gilbert Templeton, Ann Moell, Christine Weller, Melissa J. Botts, Gretel Hollon, Elsa Homberg-Pinassi, Paula Forest, Aref Bin Abhulhak, Devona Chun-Furlong, Deborah Harrington, Emily Harlynn, Marjorie Schmitt, Constance Shelsky, Patricia Feldick, Mary Cherrico, Courtney Jagle, Nicholas Warnecke, Debra Myer, Deanna J. Ruder, Albina Underwood, Alan Rauba, George Carr, Barbara Oberhaus, Jessica Vanderfeltz, Mary Jo Stucky-Heil, Dale R. Gibson, Vonnie Fuentes, Kimberly L. Talbot, William C. Simon, Katlyn J. Grimes, Christina R. Wheeler, Cassaundra Shultz, Rhonda A. Metcalf, Jennifer L. Hill, Michelle R. Oliver, Basharat Ahmad, Fouzal Azeem, Abdul Rahim, George H. Freeman, Dawn Bloch, Heather Freeman, Jamie Brown, Sarah Rosbach, Pamela Melander, Nick Taralson, Alex Liu, Katlyn Harms, Mahfouz Michale, Jose Lopez, Maria Revoredo, Shari Edevane, Sarah Shawley, Timothy L. Jackson, Michael J. Oliver, Dina DeSalle, Patricia J. Matlock, Ionna M. Beraun, Heather Hendrix, Garrett Bromley, Ashley Niemerski, Gabby Teran, Sonia Guerrero, Murtaza Marvi, Zehra Palanpurwala, Andrea Torres, Patty Gloyd, Michelle Conger, Aziz Laurent, Olia Nayor, Catalina S. Villanueva, Munira Khambati, Tabetha J. Mumford, Melanie J. Castillo, Taddese Desta, Jerome Robinson, La Shawn Woods, Anita Bahri, Nancy Herrera, Cecilia Casaclang, Jeffrey R. Unger, Geraldine Martinez, Mia K. Moon, Stephen M. Mohaupt, Larry Sandoval, Louisito Valenzuela, Victora Ramirez, Nelly Mata, Veronica Avila, Marisol Patino, Cynthia Montano-Pereira, Omar Barnett, William M. Webster, Lorraine M. Christensen, Leighna Bofman, Melanie Livingston, Stacey Adams, Joseph Hobbs, Leesa Koskela, Mia Katz, Samuel Mujica-Trenche, Franklin Cala, Noreen T. Rana, Jennifer Scarlett, Milagros Cala Anaya, Marsha R. Jones, Kelly D. Hollis, Debbie Roth, Kristin Eads, Tina Watts, Judy Perkins, Alice Arnold, Daniel C. Ginsberg, Denise Quinn, Nicole Cureton, David B. Fittingoff, Mohammed I. Iqbal, Stephen R. White, Edith Sisneros, Michelle Ducca, David Streja, Danny Campos, Jennifer L. Boak, Farzeen Amir, Felice Anderson, James J. Kmetzo, Mary O. Bongarzone, Dawn Scott, Mary Grace De Leon, Cynthia Buda, William Graettinger, Michelle Alex, Erika Hess, James Govoni, Melissa Bartel, Travis L. Monchamp, Julie S. Roach, Sara Gibson, Amy M. Allfrey, Kristen Timpy, Kathy Bott, Karin A. Soucy, Jean Willis, Cecilia A. Valerio, Anusha Chunduri, Rebecca Coker, Nicole Vidrine, Ellen A. Thompson, Mark A. Studeny, Melissa K. Marcum, Tammy S. Monway, Douglas L. Kosmicki, Melissa J. Kelley, Corey M. Godfrey, Susan L. Krenk, Randy R. Holcomb, Deb K. Baehr, Mary K. Trauernicht, David Rowland Lowry, Betty Bondy Herts, Jeanne E Phelps, Jean-Marie Downing, Carol Gamer Dignon, Elisabeth S. Cockrill, Pravinchandra G. Chapla, Diane Fera, Margaret Chang, Patricia Fredette, Tamie Ashby, Renee Bergin, Zebediah A. Stearns, David B. Ware, Rachael M. Boudreaux, Joanna Rodriguez, Robert McKenzie, Amanda Huber, Rebecca Sommers, Heather Rowe, Stacy McLallen, Michale Haynes, Ashley Adamson, Janice Henderson, Lori McClure, Beverly A. Harris, Laura Ference, Sue Meissner-Dengler, Lisa Treasure, Doreen Nicely, Timothy L. Light, Tracey A. Osborn, Kimberly J. Mai, Pablo Vivas, Jose Rios, Dunia Rodriguez, Roger DeRaad, James Walder, Oscar Bailon, Denice Hockett, Debbie Anderson, Kelli McIntosh, Amber Odegard, Andrew Shepherd, Mary Seifert, Laurence Kelley, Rajendra Shetty, Michael Castine, David Brill, Gregory Fisher, Nicole Richmond, Kathleen Gray, Patricia Miller, Charlene Coneys, Yarixa Chanza, Monica Sumoza, Victoria M. Caudill, Kelly D. Harris, Courtney A. Manion, Melody J. Lineberger-Moore, Julie J. Wolfe, Barbara J. Rosen, Patricia DiVito, Janet L. Moffat, Christina Michaelis, Prashant Koshy, Diana Perea, Ghaith Al Yacoub, Stephanie Sadeghi, Thomas D. LeGalley, Rudolph F. Evonich, William J. Jean, Gary M. Friesen, John M. Pap, David A. Pesola, Mark D. Cowan, Kristofer M. Dosh, Dianna Larson, Adele M. Price, Jodi A. Nease, Jane E. Anderson, Lori A. Piggott, Robert Iwaoka, Kevin Sharkey, Edward McMillan, Laurie Lowder, Latisha Morgan, Kyle Davis, Tara Caldwell, Erica Breglio, Jasmine Summers, Rachel Poulimas, Muhammad Zahid, Hamid Syed, Maria Escobar, Jacob Levy, Rahma Warsi, Carol Ma, Puxiao Cen, Kimberly A. Cawthon, Delores B. Barnes, Deanna G. Allen, Margaret L. Warrington, Carol R. Stastny, Robin J. Michaels, Mohamad Saleh, John Sorin, Sunny Rathod, Urakay Juett, Steven Spencer, Aziza Keval, Jill McBride, Shane Young, Catherine Baxter, Carol Rasmussen, Shari L. Coxe, Luis Campos, Shahin Tavackoli, Diana Beckham, Darlynee Sanchez, Karanjit Basrai, Dorian Helms, Erica Clinton, Kasie Smith, Henry Cusnir, Mary Klaus Clark, Madhavagopal V. Cherukuri, Ameta Scarfaru, Stephen D. Nash, Loretta C. Grimm, Anna Grace, Kylie McElheran, Dino Subasic, Zedrick Buhay, Janet Litvinoff, Deepak Shah, Shannon Cervantes, Freda Usher, Farra Yasser, Theodore Trusevich, Ronnie L. Garcia, Jamison Wyatt, Rahul Bose, Holllilyn Miska, Traci Spivey, Amy B. Wren, Katie E. Vance, Lani L. Holman, Pam Gibbons, Elaine Eby, Sandra Shepard, Soratree Charoenthongtrakul, Brett Snodgrass, Mohammed Nazem, Shelly Keteenburg, Prathima Murthy, Frederic Prater, Ashley Rumfelt, Christina Eizensmits, Lisa Iannuzzi, Pourus R. Patel, Clellia Bergamino, Elizabeth McFeaters, Botros Rizk, Emiljia Pflaum, Danny Kalish, Rex Ambatali, Mona Ameli, Delaina Sanguinetti, Rakesh Vaidya, Martinus A.W. Broeders, Dorman Henrikus, Adrianus F.M. Kuijper, Nadea Al-Windy, Michael Magro, Karim Hamraoui, Ismail Aksoy, Guy L.J. Vermeiren, H.W.O. Roeters van Lennep, Gerard Hoedemaker, Johannes Jacobus Remmen, Kjell Bogaard, Dirk van der Heijden, Nicole MJ Knufman, Joost Frederiks, Johannes Willem Louwerenburg, Piet van Rossum, Johannes Milhous, Peter van der Meer, Arno van der Weerdt, Rob Breedveld, Mitran Keijzers, Walter Hermans, Ruud van de Wal, Peter A.G. Zwart, Marc M.J.M. van der Linden, Gerardus Zwiers, Dirk J. Boswijk, Jan Geert Tans, Jacob van Eck, Maarten V. Hessen, Barnabas J.B. Hamer, Stieneke Zoet-Nugteren, Lucien Theunissen, E.A. van Beek, Remco Nijmeijer, Pieter R. Nierop, Gerard Linssen, H.P. Swart, Timo Lenderink, Gerard L. Bartels, Frank den Hartog, Brian J. Berg van den, Wouter van Kempen, Susanne Kentgens, Gloria M. Rojas Lingan, Martinus M. Peeters, Hilligje Keterberg, Melchior Nierman, Annemieke K. den Hollander, Jacqueline Hoogendijk, Christine Voors-Pette, Vicdan Kose, Peter Viergever, Larysa Yena, Viktor Syvolap, Mykola P. Kopytsya, Olga Barna, Svitlana S. Panina, Mykhailo I. Lutai, Oxana V. Shershnyova, Iryna Luzkiv, Larysa S. Bula, Sergii Zotov, Ivan Vyjhovaniuk, Olena Lysunets, Volodymyr I. Koshlia, Nataliya Sydor, Myroslava F. Vayda, Olexiy Ushakov, Mykola Rishko, Viktor P. Shcherbak, Yevgeniya Svyshchenko, Vira Tseluyko, Andriy Yagensky, Viktoriia I. Zolotaikina, Olga Godlevska, Larysa Ivanova, Olena Koval, Olena I. Mitchenko, Galyna Y. Kardash, Yurii S. Rudyk, Mykola Stanislavchuk, Volodymyr Ivanovych Volkov, Olena G. Karlinskaya, Susanna A. Tykhonova, Nikolay Vatutin, Ganna Smirnova, Volodymyr M. Kovalenko, Viktor Lizogub, Denys Sebov, Oleksandr Dyadyk, Svetlana Andrievskaya, Mykola P. Krasko, Alexander N. Parkhomenko, Lidiya Horbach, Iryna G. Kupnovytska, Tetyana Pertseva, Oleksandr Karpenko, Dmytro Reshotko, Svitlana V. Zhurba, Leonid Rudenko, Viktoriia Yu Zharinova, Valerii B. Shatylo, Yuriy I. Karpenko, Mariya A. Orynchak, Tatiana R. Kameneva, Elena Zherlitsina, Diana N. Alpenidze, Grigoriy P. Arutyunov, Elena Baranova, Boris Bart, Dmitriy I. Belenkiy, Svetlana A. Boldueva, Elena A. Demchenko, Vera V. Eltishcheva, Alexander M. Gofman, Boris M. Goloshchekin, Ivan Gennadyevich Gordeev, Nikolay Gratsianskiy, Gadel Kamalov, Niyaz R. Khasanov, Irina M. Kholina, Zhanna D. Kobalava, Elena V. Kobeleva, Alexandra O. Konradi, Victor A. Kostenko, Andrey Dmitrievich Kuimov, Polina Y. Ermakova, Sofia K. Malyutina, Alexey V. Panov, Natalia V. Polezhaeva, Olga Reshetko, Nataliya P. Shilkina, Sergey B. Shustov, Elena A. Smolyarchuk, Raisa I. Stryuk, Elena Yurievnar Solovieva, Andrey V. Susekov, Natalia Vezikova, Svetlana N. Ivanova, Alexander A. Petrov, Vladimir O. Konstantinov, Alina S. Agafina, Victor Gurevich, Konstantin N. Zrazhevskiy, Tatiana V. Supryadkina, Nikita B. Perepech, Vadim L. Arkhipovskiy, Dmitry Yu Butko, Irina A. Zobenko, Olga V. Orlikova, Viktor Mordovin, Olga L. Barbarash, Anastasiya Lebedeva, Vladimir Nosov, Oleg V. Averkov, Elena P. Pavlikova, Yuri B. Karpov, Marina Lvovna Giorgadze, Oleg A. Khrustalev, Mikhail Arkhipov, Tatiana A. Raskina, Julia V. Shilko, Yulia Samoilova, Elena D. Kosmacheva, Sergey V. Nedogoda, Kathleen Coetzee, Lesley J. Burgess, F.C.R. Theron, Iftikhar O. Ebrahim, Gerbrand A. Haasbroek, Maria Pretorius, Julien S. Trokis, Dorothea V. Urbach, Mark J. Abelson, Adrian R. Horak, Aysha E. Badat, Ellen M. Makotoko, Hendrik Du Toit Theron, Padaruth Ramlachan, Clive H. Corbett, Ismail H. Mitha, Hendrik F.M. Nortje, Dirkie J. Jansen van Rensburg, Peter J. Sebastian, F.C.J. Bester, Louis J. van Zyl, Brian L. Rayner, Elżbieta Błach, Magda Dąbrowska, Grzegorz Kania, Agata E. Kelm-Warchol, Leszek P. Kinasz, Janusz Korecki, Mariusz Kruk, Ewa Laskowska-Derlaga, Andrzej Madej, Krzysztof Saminski, Katarzyna Wasilewska, Katarzyna Szymkowiak, Małgorzata Wojciechowska, Natalia Piorowska, Andrzej Dyczek, Rajpal K. Abhaichand, Ramesh B. Byrapaneni, Basavanagowdappa Hattur, Malipeddi Bhaskara Rao, Nitin Ghaisas, Sujit Shankar Kadam, Jugal B. Gupta, Santhosh M. Jayadev, V.A. Kothiwale, Atul Mathur, Vijay Bhaskar, Ravi K. Aluri, Udaya P. Ponangi, Mukesh K. Sarna, Sunil Sathe, Manish K. Sharma, Jilendra Pal Singh Sawhney, Chakrabhavi B. Keshavamurthy, Arun Srinivas, Hemant P. Thacker, A. Sharda, Johny Joseph, Sunil Dwivedi, Viswanathan Mohan, Rajendra K. Premchand, Jacques Bedard, Jean Bergeron, Ronald Collette, David Crowley, Richard Dumas, Sam Henein, Geoff Moran, William F. O’Mahony, Michael O’Mahony, Sammy Chan, Mark H. Sherman, Graham C. Wong, Brian D. Carlson, Milan K. Gupta, David Borts, Sean R. Peterson, Martyn Chilvers, Allan J. Kelly, Jean C. Gregoire, Simon Kouz, Josep Rodés Cabau, Minodora Andor, Mircea Cinteza, Radu Ciudin, Radu I. Cojan, Roxana O. Darabont, Dan-Lucian Dumitrascu, Carmen Fierbinteanu-Braticievici, Ana Gabriela Fruntelata, Constantin Militaru, Bogdon E. Minescu, Doina Luminita Serban, Florin Mitu, Dorel Nastase Melicovici, Ovidiu Petrascu, Octavian M. Pirvu, Cristian Podoleanu, Calin Pop, Rodica-Valentina V. Stanescu-Cioranu, Adrian Tase, Cristina Voiculet, Constantine N. Aroney, Anthony M. Dart, Timothy Davis, Karam Kostner, David N. O’Neal, Peter W. Purnell, Bhuwanendu B. Singh, David R. Sullivan, Peter Thompson, Gerald F. Watts, Adam F. Blenkhorn, John V. Amerena, Rafeeq Samie, Randall Hendriks, Joseph Proietto, Nikolai Petrovsky, Alan Whelan, David Colquhoun, Russell S. Scott, Simon C. Young, Tammy Pegg, Samuel JS Wilson, Andrew W. Hamer, Richard A. Luke, Hamish H. Hart, Gerard P. Devlin, Gerard T. Wilkins, Ian F. Ternouth, Samraj Nandra, Bruno S. Loeprich, Nicole McGrath, Stuart L. Tie, Rob J. Bos, Alexandra Wils, Tamara Jacobs, Erik A. Badings, Lillian A. Ebels-Tuinbeek, Mayke L. Scholten, Esther Bayraktar-Verver, Debby Zweers, Manoek Schiks, Carolien Kalkman, Tineke Tiemes, Jeanette Mulderij, Katarzyna Dabrowska, Wilma Wijnakker, Riny Van de Loo, Jeanne de Graauw, Giny Reijnierse, Mirjam van der Zeijst, Mariska Scholten, Henk R. Hofmeijer, Antoinette van Dijk-van der Zanden, Dineke J. van Belle, Jan Van Es, Gera Van Buchem, Wendy Zijda, Harald Verheij, Linnea Oldenhof-Janssen, Martina Bader, Marije Löwik, Sandra Stuij, Pascal Vantrimpont, Krista van Aken, Karen Hamilton, Han Blömer, Gabriela van Laerhoven, Raymond Tukkie, Maarten Janssen, Gerard Verdel, Jon Funke Küpper, Bob van Vlies, Caroline Kalkman, Joke Vooges, Marinella Vermaas, Rachel Langenberg, Niek Haenen, Frans Smeets, Arko Scheepmaker, Marcel Grosfeld, Ilvy Van Lieshout, Marleen van den Berg, Marian Wittekoek, Petra Mol, Antionette Stapel, Margaretha Sierevogel, Nancy van der Ven, Annemiek Berkelmans, Eric Viergever, Hanneke Kramer, Wilma Engelen, Karen V. Houwelingen, Thierry X. Wildbergh, Arend Mosterd, Coriet Hobé-Rap, Marjan van Doorn, Petra Bunschoten, Michel Freericks, Mireille Emans, Petra Den Boer-Penning, Els Verlek, Christine Freericks, Cornelis de Nooijer, Christina Welten, Ingrid Groenenberg, Claudia van der Horst, Esther Vonk, Geert Tjeerdsma, Gerard M. Jochemsen, Corinne van Daalen, Ingrid Y. Danse, Lucy Kuipers, Anke Pieterse, Antonius Oomen, Daan de Waard, Willem Jan Flu, Zusan Kromhout, Petra Van der Bij, Rob Feld, Brigitta Hessels-Linnemeijer, Rob Lardinois, Jan L. Posma, Zwanette R. Aukema-Wouda, Marjolijn Hendriks-van Woerden, Desiree van Wijk, Driek P. Beelen, Ingrid H. Hendriks, Jan J. Jonker, Stefanie Schipperen, Vicdan Köse, Gloria Rojas, Linda Goedhart, Hanneke van Meurs, Jacqueline Rijssemus, Lindy Swinkels-Diepenmaat, Marloes de Louw-Jansen, Dominique Bierens-Peters, Willem W. van Kempen, Marianne E. Wittekoek, Irmaina Agous, Geert Schenk, Janneke Wittekoek, Kevin Cox, Deborah F. Julia, Jan J.C. Jonker, Roel Janssen, Melchor Nierman, Hilligje Katerberg, Irene van der Haar, Willem W. Van Kempen, Taco van Mesdag, Leyda M. Alvarez Costa, Manon Schensema, Salomé Zweekhorst, Deborah Font Julia, Lauri Hanewinckel, Joyce Olsthoorn, Johan C. Berends, Arie C. van der Spek, Roy van der Berg, Rob J. Timmermann, Ingrid Boerema, Iryna Mudruk, Anna Khrystoforova, Serhii Kyselov, Yaroslava V. Hilova, Pavlo Logoida, Nataliia A. Sanina, Ilona P. Golikova, Olena O. Nemchyna, Ivan I. Isaichikov, Olga B. Potapova, Iurii V. Gura, Larysa Berestetska, Olena O. Kulianda, Oleksandr Tantsura, Oleksandr S. Kulbachuk, Volodymyr Petsentiy, Ihor Biskub, Tetyana Handych, Oleg Lagkuti, Alyna Gagarina, Taras Chendey, Oksana F. Bilonko, Olena Matova, Larysa Bezrodna, Olena Yarynkina, Tetiana Ovdiienko, Volodymyr Randchenko, Maryna Mospan, Olena Butko, Olga Romanenko, Mykhailo Pavelko, Iryna Sichkaruk, Svitlana O. Lazareva, Olena A. Kudryk, Inessa M. Koltsun, Tetiana Magdalits, Sergei Zadorozhniy, Kira Kompaniiets, Andrii Ivanov, Sergiy Romanenko, Pavlo Kaplan, Vadym Y. Romanov, Oksana P. Mykytyuk, Nataliia S. Zaitseva, Sergiy N. Pyvovar, Lyudmyla Burdeuna, Emerita Serdobinska, Tatiana I. Shevchenko, Igor I. Ivanytskyi, Olena V. Khyzhnyak, Nataliya Kalinkina, Olena Keting, Olena Sklyanna, Olga Kashanska, Anna Shevelok, Marina Khristichenko, Ievgenii Y. Titov, Danilenko O. Oleksander, Nataliia S. Polenova, Nataliia Altunina, Viktoriia Kororaieva, Stanislav Zborovskiy, Leonid Kholopov, Iurii Suliman, Lanna Lukashenko, Stanislav Shvaykin, Olexandr M. Glavatskiy, Roman O. Sychov, Roman L. Kulynych, Oleksandr A. Skarzhevskyi, Nataliia V. Dovgan, Marta Horbach, Olga Cherkasova, Iryna Tyshchenko, Liudmyla Todoriuk, Svitlana Kizim, Nataliia Brodi, Oleksandr Ivanko, Olga Garbarchuk, Liudmyla Alieksieieva, Tetiana L. Shandra, Olena Beregova, Larisa An Bodretska, Svitlana S. Naskalova, Ivanna A. Antoniuk-Shcheglova, Olena V. Bondarenko, Natalia G. Andreeva, Iryna I. Vakalyuk, Olha S. Chovganyuk, Nataliya R. Artemenko, Kiril A. Maltsev, Natalia Kalishevich, Natalia G. Kondratyeva, Svetlana A. Nikitina, Maria V. Martjanova, Anna V. Sokolova, Dmitrii O. Dragunov, Olga Kolesnik, Vera Larina, Oxana V. Tsygankova, Maria Ivanova, Illia A. Karpov, Elena M. Aronova, Ekaterina S. Vedernikova, Ekaterina I. Lubinskaya, Taras Y. Burak, Sergey I. Skichko, Farhad Rasulev, Ekaterina B. Soldatova, Alexander L. Fenin, Ilya I. Laptev, Elena E. Luchinkina, Alexandr Akatov, Natalia V. Polenova, Natalia N. Slavina, Irina N. Korovnika, Marina Yu Prochorova, Regina Shakirova, Elena N. Andreicheva, Olga A. Krasnova, Tinatin V. Lobzhanidze, Tatiana B. Dmitrova, Viktoriya V. Stakhiv, Maria I. Pechatnikova, Alexandra V. Panova, Maria Y. Tipikina, Oxana P. Rotar, Nikolay A. Bokovin, Saule K. Karabalieva, Farid Y. Tumarov, Elena V. Vasileva, Natalya Gennadevna Lozhkina, Ekaterina V. Filippova, Alisa I. Sharkaeva, Ekanerina V. Filippova Deilik, Natalia Yu Tolkacheva, Elena N. Domracheva, Andrey N. Ryabikov, Inga T. Abesadze, Marianna Z. Alugishvili, Elena P. Nikolaeva, Nadezda V. Smirnova, Valentina I. Rodionova, Polina V. Dolovstaya, Igor E. Yunonin, Sergey V. Kadin, Tatyana S. Sveklina, Anna V. Bushmanova, Elena L. Barkova, Irina S. Gomova, Yana V. Brytkova, Tatiana B. Ivanova, Marina Y. Zubareva, Inga Skopets, Lybov A. Galashevskaya, Emilia D. Butinskaya, Olga G. Gusarova, Natalia B. Kalishevich, Yana R. Pavlova, Marianna P Serebrenitskaya, Vitalina F. Grygorieva, Gulnara R. Kuchaeva, Inna A. Vasileva, Gulnara I. Ospanova, Yulia V. Vahrusheva, Irina A. Semenova, Irina E.E. Mikhailova, Olga O. Kvasova, Valeria D. Shurygina, Alexey E. Rivin, Alexey O. Savelyev, Alexey A. Savelyev, Olesya O. Milyaeva, Nadezhda N. Lapshina, Ninel A. Lantsova, Pavel V. Alexandrov, Evgeniy A. Orlikov, Alla Falkovskaya, Tatiana Ripp, Sergei Triss, Stanislav Pekarskiy, Sitkova Ekaterina, Evgeniya N. Zhuravleva, Olga Perova, Galina Kovaleva, Liubov Koroleva, Lydia Mishchenko, Boris P. Garshin, Svetlana A. Kutuzova, Lyudmila I. Provotorova, Igor P. Zadvorny, Olga V. Okhapkina, Anatoly O. Khrustalev, Tatiana Suvorova, Elena S. Shaf, Varvara A. Vershinina, Andrey A. Kozulin, Oxana A. Oleynik, Irina Y. Martynova, Natalia V. Kizhvatova, Alla S. Salasyuk, Vera V. Tsoma, Alla A. Ledyaeva, Elena V. Chumachek, S.C. Blignaut, Tersia Y. Alexander, Chano Du Plessis, Thirumani Govender, Samatha M. Du Toit, Leya Motala, Areesh Gassiep, Christina Naude (Smit), Marli Terblanche, Marlien Snoer (Kruger), Berenice Pillay, De Vries Basson, Marisa E. Theron, Bianca Fouche, Mareli E. Coetzee, Pieter Odendall, Frederik H. Van Wijk, Anna-Mari Conradie, Trudie Van der Westhuizen, Carine Tredoux, Mohamed S. Mookdam, Andie J. Van der Merwe, Karin Snyman, Gerda Smal, Yvonne De Jager, Thomas A. Mabin, Annusca King, Lindy L. Henley, Brenda M. Zwane, Jane Robinson, Marinda Karsten, Andonia M. Page, Valerie Nsabiyumva, Charmaine Krahenbuhl, Jaiprakash D. Patel, Yunus E. Motala, Ayesha Dawood, Nondumiso B. Koza, Lenore M.S. Peters, Shavashni Ramlachan, Wilhelm J. Bodenstein, Pierre Roux, Lizelle Fouche, Cecilia M. Boshoff, Haroon M. Mitha, Fathima Khan, Henry P. Cyster, Helen Cyster, E. C. Wessels, Florence J. Jacobs, Melanie A. Sebastian, Deborah A. Sebastian, Nadia Mahomed, Ignatius P. Immink, Celia Cotzee, Tanja Cronje, Madele Roscher, Maria Le Roux, Yvonne A. Trinder, Renata Wnętrzak-Michalska, Magdalena Piszczek, Andrzej Piela, Ewa Czernecka, Dorota Knychas, Alina Walczak, Izabella Gładysz, Katarzyna Filas, Ewelina Kiluk, Krzysztof Świgło, Iwona Jędrzejczyk, Kamila Łuczyńska, Katarzyna Tymendorf, Wojciech Piesiewicz, Wojciech L. Kinasz, Stefan Samborski, Ilona Bartuś, Gramzyna Latocha Korecka, Ewa Gulaj, Jolanta Sopa, Bogusław Derlaga, Marcin Baisiak, Allicia Kowalisko, Edyta Stainszewska-Marasazlek, Bartosz Szafran, Malgorzata Swiatkiewicz, Artur Racewicz, Sławomir Grycel, Jerzy Supronik, Sylwia Walendziuk, Magdalena Tarantowicz, Agata Stasiak, Anna Sidorowicz-Białynicka, Marek Dwojak, Ewa Jaźwińska-Tarnawska, Katarzyna Kupczyk, Kamila Martowska, Kamila Kulon, Katarzyna Gajda, Bivin Wilson, Krithika Velusamy, Swaidha S. Sadhiq, Bhavani Siddeshi, M. Bhanukumar, Abhishek Srivatsav, Madhan Ramesh, Sri Harsha Chalasani, Mini Johnson, Prashanth Gopu, Jeesa George, Sowmya Reddy, Swetha Tessy Thara Eleena, Damodara Rao Kodem, Haritha N. Nakkella, Padma Kumari Mandula, Anjan Kumar Vuriya, Syamala Rajana, Aruna Kale, Tiwari Rajeev, Raina Jain, Vipin Jain, Srilakshmi Mandayam Adhyapak, Lumin Sheeba, Uma C R, Ramya R, Aditya V. Kulkarni, M.S. Ganachari, Ruma Sambrekar, Mohammad Bilal, Kalyan Chakravarthy, Ravi Badhavath, Sravan Kumar, Meenakshi Simhadri, Farooque Salamuddin, Venkat Prasad, Vivek Dwivedi, Sudha Sarna, Tilak Arora, Deepak Chawla, Archana Sathe, Chaware Gayatree, Ajeet Nanda, Ram Avtar, Jyoti Sharma, Vaibhavi P S, Sasirekha D, Deepthi Kobbajji, Ramya Ningappa, Shwetha Shree, Chandrashekar K, Nandini M R, Sowjanya S, Devika I G, Yashaswini N, Sonika G, Rathna L, Priyanka R, Rupal J. Shrimanker, Lakshmi Vinutha Reddy, K. Sumathi, Babitha Devi, Bina N. Naik, Rohini Manjunath, Rajeshwari Ashok, Tony V. Kunjumon, Jesline Thomas, Shaik Samdhani, Kasthuri Selvam, Poongothai Subramani, Nandakumar Parthasarathy, Nirmal K. Bohra, Anvesh K. Gatla, Cheryl Horbatuk, Julie Sills, E B. Davey, Liz Paramonczyk, Olga Racanelli, Sandy Strybosch, Andre Belanger, Jean Palardy, Alicia Schiffrin, Sylvie Gauthier, Norman Kalyniuk, Shawn D. Whatley, Heather Lappala, Grishma Patel, Matthew Reeve, Catherine Moran, Jody Everitt, Teresa Ferrari, Christine Bouffard, Jirir Frohlich, Gordon Francis, John Mancini, Gregory Bondy, Debbie DeAngelis, Patricia Fulton, David W. Blank, Angela Lombardo, Mylène Roy, Jackie Chow, Hyman Fox, William J. Grootendorst, Angela Hutchinson, Sharon M. Chan, Christie Fitzgerald, Lynn Wilkins, Rebecca L. Raymond, Arlene Reyes, Lavoie Marc André, Denis Fortin, Hélène Ouimet, Thanh-Thao Tôn-Nu, Martine Dussureault, Marie-Hélène Blain, Madeleine Roy, Nathalie Kopajko, Chantal Fleury, Karine Maheux, Gabriela Valentina Ciobotaru, Maria C. Constantinescu, Carmen-Lucia Gherghinescu, Ana-Maria Avram, Ioan Manitiu, Aura Sinpetrean, Lucian Pop, Delia Lupu, Radu Usvat, Ana Petrisor, Nicoleta Dumitru, Camelia Moruju, Adelina Gheorghita, Magda V. Mitu, Cosmin Macarie, Ana Maria Pop, Maria-Catalina Diaconu, Iulia Grancea, Mihaela Cosma, Mihaela Crisan, Elizabeth Herron, Paul Nestel, Sally B. Kay, Kaye S. Carter, Imran Badshah, Ashley Makepeace, Jocelyn Drinkwater, Michelle England, Azette Rafei, Kylie Patterson, Alicia Jenkins, Sybil McAuley, Sue M. Kent, Joy E. Vibert, Leonie Perrett, Thomas David, Samantha L. Kaye, Monika O’Connor, Nimalie J. Perera, Nicole T. Lai, Kerry A. Kearins, Christinia Dicamillo, Heather Anderson, Louise Ferguson, Sharon D. Radtke, Charles T. Thamarappillil, Janice M. Boys, Anita K. Long, Toni Shanahan, Michael Nyguyen, Nicole Forrest, Gill Tulloch, Della Greenwell, Sarah L. Price, Aye N. Tint, Priya K. Sumithran, Tamara L. Debreceni, Lisa Walker, Mary Caruana, Kira Edwards, Maria Stathopoulos, Cilla Haywood, Dimitar Sajkov, Sharen Pringle, Anne Tabner, Kathrina Bartolay, Chamindi Abeyratne, Kylie Bragg, Patrick Mulhern, Peter Purnell, Lyn Williams, Jane Hamlyn, Aurelia Connelly, Jan Hoffman, Samantha Bailey, Jane Kerr, Zarnia Morrison, Sarah Maeder, Roberta McEwan, Prasanna Kunasekera, Patrice McGregor, Jo Young, Sharon Berry, Rick Cutfield, Michelle Choe, Catherine McNamara, Narrinder K. Shergill, Petra Crone, Miles G. Williams, Keith Dyson, Diana H. Schmid, Audrey C. Doak, Melissa Spooner, Colin Edwards, Anne Turner, Grainne M. McAnnalley, Raewyn A. Fisher, Fraser B. Hamilton, Denis H. Friedlander, Melissa R. Kirk, Jayne E. Scales, Marguerite A. McLelland, Neelam A. Dalman, Cathy E. Vickers, Carolyn Jackson, Wendy Coleman, Phillip I. Garden, and Wendy F. Arnold

Subjects
Male, medicine.medical_specialty, Rate ratio, Double-Blind Method, Ischemia, Risk Factors, Physiology (medical), Internal medicine, medicine, Clinical endpoint, Humans, Myocardial infarction, Coronary Artery Bypass, Stroke, Aged, business.industry, Unstable angina, Hazard ratio, Absolute risk reduction, Middle Aged, medicine.disease, Eicosapentaenoic Acid, Number needed to treat, Cardiology, Female, Cardiology and Cardiovascular Medicine, business
Abstract

Background: Despite advances in surgery and pharmacotherapy, there remains significant residual ischemic risk after coronary artery bypass grafting surgery. Methods: In REDUCE-IT (Reduction of Cardiovascular Events With Icosapent Ethyl–Intervention Trial), a multicenter, placebo-controlled, double-blind trial, statin-treated patients with controlled low-density lipoprotein cholesterol and mild to moderate hypertriglyceridemia were randomized to 4 g daily of icosapent ethyl or placebo. They experienced a 25% reduction in risk of a primary efficacy end point (composite of cardiovascular death, myocardial infarction, stroke, coronary revascularization, or hospitalization for unstable angina) and a 26% reduction in risk of a key secondary efficacy end point (composite of cardiovascular death, myocardial infarction, or stroke) when compared with placebo. The current analysis reports on the subgroup of patients from the trial with a history of coronary artery bypass grafting. Results: Of the 8179 patients randomized in REDUCE-IT, a total of 1837 (22.5%) had a history of coronary artery bypass grafting, with 897 patients randomized to icosapent ethyl and 940 to placebo. Baseline characteristics were similar between treatment groups. Randomization to icosapent ethyl was associated with a significant reduction in the primary end point (hazard ratio [HR], 0.76 [95% CI, 0.63–0.92]; P =0.004), in the key secondary end point (HR, 0.69 [95% CI, 0.56–0.87]; P =0.001), and in total (first plus subsequent or recurrent) ischemic events (rate ratio, 0.64 [95% CI, 0.50–0.81]; P =0.0002) compared with placebo. This yielded an absolute risk reduction of 6.2% (95% CI, 2.3%–10.2%) in first events, with a number needed to treat of 16 (95% CI, 10–44) during a median follow-up time of 4.8 years. Safety findings were similar to the overall study: beyond an increased rate of atrial fibrillation/flutter requiring hospitalization for at least 24 hours (5.0% vs 3.1%; P =0.03) and a nonsignificant increase in bleeding, occurrences of adverse events were comparable between groups. Conclusions: In REDUCE-IT patients with a history of coronary artery bypass grafting, treatment with icosapent ethyl was associated with significant reductions in first and recurrent ischemic events. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT01492361.

Published
2021
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29. Diabetic Agents, From Metformin to SGLT2 Inhibitors and GLP1 Receptor Agonists

Author

Jonathan D. Newman, Christophe De Block, Tanya Wilcox, and Arthur Schwartzbard

Subjects
business.industry, Type 2 Diabetes Mellitus, Type 2 diabetes, Disease, 030204 cardiovascular system & hematology, Bioinformatics, medicine.disease, Article, Metformin, 03 medical and health sciences, 0302 clinical medicine, Diabetes Mellitus, Type 2, Cardiovascular Diseases, Diabetes mellitus, medicine, Humans, Hypoglycemic Agents, 030212 general & internal medicine, Cardiology and Cardiovascular Medicine, business, Adverse effect, Dipeptidyl peptidase-4, Kidney disease, medicine.drug
Abstract

Given the intersection between diabetes mellitus and cardiovascular disease (CVD), pharmacologic agents used to treat type 2 diabetes mellitus must show cardiovascular safety. Comorbid conditions, including heart failure and chronic kidney disease, are increasingly prevalent in patients with diabetes; therefore, they also play a large role in drug safety. Although biguanides, sulfonylurea, glitazones, and dipeptidyl peptidase 4 inhibitors have variable effects on cardiovascular events, sodium glucose cotransporter 2 inhibitors and glucagon-like peptide 1 receptor agonists have consistently shown safety and reduction in cardiovascular events in patients with established CVD. These medications are becoming essential tools for cardioprotection for patients with diabetes and CVD. They may also have roles in primary prevention and renal protection. This paper will review the cardiovascular impact, adverse effects, and possible mechanisms of action of pharmacologic agents used to treat patients with type 2 diabetes.

Published
2020
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36. Icosapent Ethyl Reduces Ischemic Events in Patients With a History of Previous Coronary Artery Bypass Grafting: REDUCE-IT CABG

Author

Verma, Subodh, primary, Bhatt, Deepak L., additional, Steg, Ph. Gabriel, additional, Miller, Michael, additional, Brinton, Eliot A., additional, Jacobson, Terry A., additional, Dhingra, Nitish K., additional, Ketchum, Steven B., additional, Juliano, Rebecca A., additional, Jiao, Lixia, additional, Doyle, Ralph T., additional, Granowitz, Craig, additional, Gibson, C. Michael, additional, Pinto, Duane, additional, Giugliano, Robert P., additional, Budoff, Matthew J., additional, Mason, R. Preston, additional, Tardif, Jean-Claude, additional, Ballantyne, Christie M., additional, Martens, Fabrice M.A.C., additional, Schut, Astrid, additional, Olshansky, Brian, additional, Chung, Mina, additional, Hallstrom, Al, additional, Pearce, Lesly, additional, Mehta, Cyrus, additional, Mukherjee, Rajat, additional, Chakrabarti, Anjan K., additional, Gelfand, Eli V., additional, Leary, Megan Carroll, additional, Pinto, Duane S., additional, Pride, Yuri B., additional, Ketchum, Steven, additional, Bhavanthula, Ramakrishna, additional, Chester, Gertrude, additional, Copland, Christina, additional, Diffin, Katelyn, additional, Doyle, Ralph, additional, Erz, Kurt, additional, Giaquinto, Alex, additional, Glanton, Paula, additional, Granger, Angela, additional, Iroudayassamy, Richard H., additional, Juliano, Rebecca, additional, Jin, James, additional, Klevak, Dimitry, additional, Panchal, Hardik, additional, Wang, Robert, additional, Wang, Shin-Ru, additional, Abate, Gerard, additional, Berry, Peggy J., additional, Braeckman, Rene, additional, Doogan, Declan, additional, Elson, Anne, additional, HauptmannBaker, Amy, additional, Lamela, Isabel, additional, Lubeck, Catherine, additional, Manku, Mehar, additional, Murphy, Sabina, additional, Sanford, Monica, additional, Stirtan, William, additional, Soni, Paresh, additional, Bastien, Arnaud, additional, Foster, Demetria, additional, Gascon, Evangelito, additional, Johnson, Judith, additional, Latona, Lasbert, additional, Liu, Gang, additional, Palleja, Sandra, additional, Sanjuan, Nelly, additional, Shi, Jimmy, additional, Stager, William, additional, Venkatakrishnan, Mukund, additional, Youssef-Agha, Ahmed, additional, Zhu, Julie, additional, Aertker, Leela, additional, Ankolekar, Suresh, additional, Goldberg, Lisa, additional, Rajicic, Natasa, additional, Shu, Jianfen, additional, Zou, Heng, additional, Mikhail, Magdy, additional, Dawood, Gamil, additional, Koshy, N. Mathew, additional, Mukherjee, Sandip K., additional, Abadier, Rafik, additional, Lawless, Andrea L., additional, McGuinn, William P., additional, Weintraub, Howard, additional, Rohr, Kathryn, additional, Claxton, Edmund, additional, Weiss, Robert J., additional, Klein, Terry D., additional, Nallasivan, Mani, additional, Crowley, Stephen, additional, King, Marilyn, additional, Alfieri, Anthony D., additional, Fitz-Patrick, David, additional, Loh, Irving, additional, Mayer, Nolan J., additional, Prashad, Rakesh, additional, Lederman, Samuel, additional, Weinstein, Debra, additional, Bays, Harold E., additional, Chu, Keith, additional, Maghsoudi, Alireza, additional, Thompson, Paul D., additional, Carstens, Jeff, additional, Chang, Anna, additional, Cohen, Kenneth R., additional, Dean, Julius, additional, Ellison, Howard S., additional, Erickson, Bernard, additional, Flores, Enrique A., additional, Gottlieb, Daniel W., additional, Grena, Paul, additional, Guyton, John R., additional, Jones, Peter H., additional, Joseph, John M., additional, Lepor, Norman E., additional, Lerman, Sam, additional, Matheney, Robert D., additional, Pacheco, Theodore R., additional, Russo, Michael B., additional, Rubino, John, additional, Pereira, Edward S., additional, Seals, Albert A., additional, Viera, Eduardo, additional, Steljes, Alan D., additional, Thompson, Jason, additional, Kapadia, Shaival, additional, McIvor, Michael, additional, Salazar, Jorge E., additional, Santiago, Jose O., additional, Vicari, Ralph, additional, Berk, Martin R., additional, Kaye, William A., additional, McKenzie, Marcus, additional, Podlecki, David, additional, Snyder, Brian D., additional, Nash, Stephen, additional, Herrington, David M., additional, Johnson, Wallace, additional, Lee, Joseph R., additional, Blonder, Ronald, additional, Patel, Alpa M., additional, Castello, Ramon, additional, Greco, Susan, additional, Kereiakes, Dean J., additional, Nadar, Venkatesh K., additional, Nathan, Mark, additional, Potu, Ranganatha P., additional, Sangrigoli, Robert, additional, Smalling, Richard, additional, Davis, Mitchell, additional, Braastad, Robert, additional, McCriskin, James, additional, Bodiwala, Kunal, additional, Hargrove, Joe L., additional, Graves, Mark W., additional, Emlein, George, additional, Durant, Raegan W., additional, Clower, James W., additional, Arora, Rohit, additional, Singh, Narendra, additional, Warsinger Martin, Lisa, additional, Haught, W Herbert, additional, Litt, Marc P., additional, Klein, Michael D., additional, Hoagland, Peter, additional, Goldstein, Michael, additional, Mazzella, Marco S., additional, Dunker, Daniel H., additional, Kahn, Brian H., additional, Ince, Carlos S., additional, McGrew, Frank A., additional, Lee, Jay, additional, Pan, David, additional, Khan, Salman A., additional, Elkayam, Uri, additional, Deeb, Wasim, additional, Goldberg, Anne C., additional, Brown, Christopher S., additional, Leimbach, Wayne N., additional, Backer, Thomas S., additional, Sutton, David R., additional, Gellman, Joel, additional, George, Anu R., additional, Hoffman, Alan S., additional, Kates, Mark, additional, Anand, Kishlay, additional, Bear, Robert, additional, Cavanaugh, Brendan J., additional, Reyes, Ramon G., additional, Sotolongo, Rodolfo, additional, Sabatino, Kenneth, additional, Gallagher, Kevin, additional, Sorial, Ehab, additional, Geohas, Chris, additional, Magness, Kathleen E., additional, Grunstra, Bernard P., additional, Martin, Frederik A., additional, Knapp, William S., additional, Lucas, Mel E., additional, Champlin, John J., additional, Demattia, Jason, additional, Peters, Patrick H., additional, Kirstein, Judith, additional, Randall, William J., additional, Staniloae, Cezar S., additional, Robinson, Jennifer G., additional, Adler, Alexander, additional, Case, Christopher, additional, Kaplan, Andrew J., additional, Lakin, Gregory F., additional, Goyle, Krishan K., additional, DiGiovanna, Michael J., additional, Fisher, Chester L., additional, Lillestol, Michael, additional, Robinson, Michael, additional, Perry, Robert G., additional, Levinson, Lawrence S., additional, Everhart, Brian G., additional, Madder, Robert D., additional, Martin, Earl F., additional, Martin, Earl E., additional, Alam, Imtiaz, additional, Elacion, Jose Mari L., additional, Poonawala, Robina, additional, Desta, Taddese T., additional, Robinson, Jerome A., additional, Martinez, Gilbert J., additional, Reddy, Jakkidi S., additional, Wayne, Jeffrey D., additional, Mujica Trenche, Samuel, additional, Kaplan, Westbrook I., additional, Saavedra, Rubin H., additional, DiGregorio, Michael D., additional, Bertolet, Barry D., additional, Fraser, Neil J., additional, Hart, Terence T., additional, Graf, Ronald J., additional, Jasper, David A., additional, Dunn, Michael, additional, Streja, Dan A., additional, Strobl, David J., additional, Jiang, Nan, additional, Kalen, Vicki, additional, Mascolo, Richard, additional, Samson, Mercedes B., additional, Stephens, Michael, additional, Bellard, Bret M., additional, Juarez, Mario, additional, McCarthy, Patrick J., additional, Checton, John B., additional, Stillabower, Michael, additional, Goldenberg, Edward, additional, Karim, Amin H., additional, Jaffrani, Naseem, additional, Touchon, Robert C., additional, Fruehling, Erich R., additional, Friesen, Clayton J., additional, Chaudhuri, Pradipta, additional, Morris, Frank H., additional, Broker, Robert E., additional, Patel, Rajesh J., additional, Hole, Susan, additional, Miller, Randall P., additional, Miranda, Francisco G., additional, Dar, Sadia, additional, Gentry, Shawn N., additional, Hermany, Paul, additional, Treasure, Charles B., additional, Trevino, Miguel E., additional, Acosta, Raimundo, additional, Japour, Anthony, additional, Durr, Samuel J., additional, Wang, Thomas, additional, Ganda, Om P., additional, Krichmar, Perry, additional, Arter, James L., additional, Jacoby, Douglas, additional, Schwartz, Michael A., additional, Al-Karadsheh, Amer, additional, Gencheff, Nelson E., additional, Pasquini, John A., additional, Dunbar, Richard, additional, Kohnstamm, Sarah, additional, Lozano, Hector F., additional, Welty, Francine K., additional, Pitts, Thomas L., additional, Zehnder, Brian, additional, El Hafi, Salah, additional, King, Mark A., additional, Ghitis, Arnold, additional, Bahu, Marwan M., additional, Ranjbaran Jahromi, Hooman, additional, Caputo, Ronald P., additional, Busch, Robert S., additional, Shapiro, Michael D., additional, Zavaro, Suhail, additional, Daudjee, Munib, additional, Jacobs, Shahram, additional, Shah, Vipul B., additional, Rubalcava, Frank, additional, Alhaddad, Mohsin T., additional, Lui, Henry, additional, Rajan, Raj T., additional, Saba, Fadi E., additional, Gunapooti, Mahendra Pai N, additional, Kayembe, Tshiswaka B., additional, Jennings, Timothy, additional, Strzinek, Robert A., additional, Shanik, Michael H., additional, Singh, Pradeep K., additional, Kennedy, Alastair C., additional, Rubenstein, Howard, additional, Manshadi, Ramin, additional, Ladner, Joanne, additional, Kakish, Lily, additional, Kakish, Ashley, additional, Little, Amy L., additional, Gerber, Jaime, additional, Hinchion, Nancy J., additional, Guarino, Janet, additional, Raychok, Denise, additional, Budzinski, Susan, additional, Kelley-Garvin, Kathleen, additional, Beckord, April, additional, Schlinder, Jessica, additional, Schwartzbard, Arthur, additional, Cobos, Stanley, additional, Freeman, Deborah, additional, Abisalih, David, additional, McCann, Dervilla, additional, Guy, Kylie, additional, Chase, Jennifer, additional, Samuelson, Stacey, additional, Cassidy, Madeline, additional, Tardif, Marissa, additional, Smith, Jaime, additional, Sprout, Brenna, additional, Riedeman, Nanette, additional, Goza, Julie, additional, Johnson, Lori, additional, Kraske, Chad, additional, Hastings, Sheila, additional, Dutka, Chris, additional, Smith, Stephanie, additional, McCabe, Toni, additional, Maloney, Kathleen, additional, Alfieri, Paul, additional, Hosemane, Vinay, additional, Syravanh, Chanhsamone, additional, Pau, Cindy, additional, Limcoiloc, April, additional, Carreira, Tabitha, additional, Kurosawa, Taryn S., additional, Krumian, Razmig, additional, Preston, Krista, additional, Nashed, Ashraf, additional, Schneidman-Fernandez, Daria, additional, Patterson, Jack, additional, Tsakonas, John, additional, Esaki, Jennifer, additional, Sprafka, Lynn, additional, Patel, Porous, additional, Mitchell, Brian, additional, Ross, Erin M., additional, Miller, Donna, additional, Prashad, Akash, additional, Feyler, Kristina M., additional, Juarbe, Natasha, additional, Herrera, Sandra, additional, Keiran, Sarah M., additional, Whitehead, Becky, additional, Asher, Whitney, additional, Hobbs, Coury, additional, Elie, Abbey, additional, Brooks, Jean, additional, Zaleski, Amanda L., additional, Foxen, Brenda, additional, Lapke, Barb, additional, Wright, Philippa, additional, Pavol, Bristol, additional, Carangi, Gwen, additional, Turner, Marla, additional, Sanders, Katharine W., additional, Delamar, Rikita S., additional, Wilson, Virginia L., additional, Harvel, Sarah M., additional, Cartledge, Alison M., additional, Bailey, Kaitlyn R., additional, Mahon, Kathleen, additional, Schuchard, Timothy, additional, Humbert, Jen, additional, Hanson, Mark C., additional, Cecil, Michael P., additional, Abraham, James S., additional, Benedict, Lorie, additional, Slayton, Claudia, additional, Burnett, Curtis S., additional, Ono-Lim, Rachel W., additional, Budzinski, Sharon, additional, Khan, Shubi A., additional, Goss, Sharon, additional, Techmanski, Terry, additional, Valliani, Farida, additional, Joseph, Rimla, additional, Flores, Edith, additional, Contreras, Laurn, additional, Aguillon, Ana, additional, Silvia, Carrie-Ann, additional, Martin, Maria, additional, Kerut, Edmund K., additional, Levenson, Leslie W., additional, Glade, Louis B., additional, Cospolich, Brian J., additional, Stein, Maureen W., additional, LaGuardia, Stephen P., additional, Sonza, Thelma L., additional, Fife, Tracy M., additional, Forschler, Melissa, additional, Watts, Jasmyne, additional, Fritsch, Judy, additional, Futchko, Emese, additional, Utech, Sarah, additional, Baker, Scott B., additional, Roura, Miguel F., additional, Segel, Scott A., additional, Magee, James S., additional, Jackson, Cathy, additional, Goldfaden, Rebecca F., additional, Quas, Liudmila, additional, Ortiz, Elizabeth C., additional, Simpson, Michael, additional, Foster, Robert, additional, Brian, Christopher, additional, Trimm, James, additional, Bailey, Michael, additional, Snoddy, Brian, additional, Reeder, Van, additional, Wilkinson, Rachel, additional, Settle, Harold, additional, Massey, Cynthia, additional, Maiola, Angela, additional, Hall, Michele, additional, Hall, Shelly, additional, Hall, Wanda, additional, Xenakis, Mark, additional, Barrett, Janet, additional, Campanile, Giovanni, additional, Anthou, David, additional, Neill, Susan F., additional, Karas, Steven, additional, Polanco, Enrique, additional, Schechtman, Norberto, additional, Tischner, Grace, additional, Warren, Kay, additional, St Cyr, Cynthia, additional, Kuczinski, Menna, additional, Alexander, Latrina, additional, Ibarra, Maricruz, additional, Horowitz, Barry S., additional, Steinsapir, Jaime, additional, Mangual-Coughlin, Jeanette, additional, Mooney, Brittany, additional, Vasquez, Precilia, additional, Rodkey, Kathleen, additional, Biberstein, Alexandria, additional, Ignacio, Christine, additional, Robinson, Irina, additional, Hibberd, Marcia, additional, Hoffman, Lisa B., additional, Murak, Daniel J., additional, Varavenkataraman, Raghupathy, additional, Ohlson Elliott, Theresa M., additional, Cunningham, Linda A., additional, Palmerton, Heather L., additional, Poole, Sheri, additional, Moore, Jeannine, additional, Wallace, Helene, additional, Chandler, Ted, additional, Riley, Robert, additional, Dawood, Farah, additional, Azeem, Amir, additional, Cammarata, Michael, additional, Owen, Ashleigh, additional, Aggarwal, Shivani, additional, Qureshi, Waqas, additional, Almahmoud, Mohamed, additional, Oseni, Abdullahi, additional, Leigh, Adam, additional, Barnes, Erin, additional, Pflum, Adam, additional, Aladin, Amer, additional, Blinson, Karen, additional, Wayne, Vickie, additional, Doomy, Lynda, additional, Wall, Michele, additional, Bitterman, Valerie, additional, Young, Cindi, additional, Grice, Rachel, additional, Poliakova, Lioubov, additional, Davalos, Jorge, additional, Rosenbaum, David, additional, Boulware, Mark, additional, Mazzola, Heather, additional, Strader, J. Russell, additional, Linsky, Russell, additional, Schwartz, David, additional, Graf, Elizabeth, additional, Gneiting, Alicia, additional, Palmblad, Melissa, additional, Donlin, Ashley, additional, Ensminger, Emily, additional, Garcia, Hillary, additional, Robinson, Dawn, additional, Tran, Carolyn, additional, Jacqmein, Jeffrey, additional, Bartilucci, Darlene, additional, Koren, Michael, additional, Maluchnik, Barbara, additional, Parks, Melissa, additional, Miller, Jennifer, additional, DeFosse, Cynthia, additional, Knouse, Albert B., additional, Delancey, Amy, additional, Chin, Stephanie, additional, Stephens, Thomas, additional, Sohal, Mag, additional, Ingram, Juana, additional, Kumar, Swarooparani, additional, Foley, Heather, additional, Smith, Nina, additional, McKinney, Vera, additional, Schwarz, Linda, additional, Moore, Judith, additional, Anderson, Hildreth Vernon, additional, Sdringola-Maranga, Stefano, additional, Denktas, Ali, additional, Turrentine, Elizabeth, additional, Patterson, Rhonda, additional, Marshall, John, additional, Tolar, Terri, additional, Patrick, Donna, additional, Schwartzkopf, Pamela, additional, Fletcher, Anthony M., additional, Harris, Frances R., additional, Clements, Sherry, additional, Brown, Tiffany, additional, Smith, William, additional, Baehl, Stacey J., additional, Fluty, Robin, additional, VanHamersveld, Daniel, additional, Breen, Dennis, additional, Bender, Nancy, additional, Stafford, Beverly, additional, Washington, Tamika, additional, Pike, Margaret N., additional, Stich, Mark A., additional, Jawad, Evyan, additional, Nadeem, Amin, additional, Nyland, Jill, additional, Hamer, Rhonda, additional, Calhoun, Kendra, additional, Mall, Charlotte, additional, Cadogan, Samuel, additional, Raynes, Kati, additional, Katz, Richard, additional, Marshall, Lorraine, additional, Abbas, Rashida, additional, Dinerman, Jay L., additional, Hartley, John T., additional, Lamb, Beth, additional, Eskridge, Lisa, additional, Raymond, Donna, additional, Clemmer, Kristy, additional, Fine, Denise M., additional, Beardsley, Paula, additional, Werner, Janet, additional, Mahan, Bette, additional, VanTol, Courtney, additional, Herman, Robert, additional, Raiser-Vignola, Christine, additional, McShan, Felicia, additional, Neill, Stefanie A., additional, Blick, David R., additional, Liston, Michael J., additional, Nelson, Denetta K., additional, Dorrell, Sandra K., additional, Wyman, Patricia, additional, Quraishi, Ambereen, additional, Ferro, Fernando, additional, Morris, Frank, additional, Coombs, Vicki J., additional, Mains, Autumn M., additional, Campbell, Austin A., additional, Phelps, Jeanne, additional, Geary, Cheryl A., additional, Sheridan, Ellen G., additional, Downing, Jean M., additional, Swatkowski, Arie, additional, Redden, Tish, additional, Dragutsky, Brian, additional, Thomas, Susan, additional, Mitchell, Candace, additional, Barker, Diana, additional, Turcotte, Elanie, additional, Segerson, Deborah, additional, Guy, Jill, additional, De La Mora, Karena, additional, Hong, Jennifer, additional, Do, Dennis, additional, Norris, Rose, additional, Khan, Faisal, additional, Montero, Hector, additional, Kelly-White, Stacy, additional, Cleland, Alan, additional, Alcalde-Crawford, Rosalyn, additional, Morgan, Melissa, additional, Sarabu, Brijmohan, additional, Minor, Megan, additional, Kamat, Shweta, additional, Estes, Stephanie M., additional, Harless, Nancee, additional, Disney, Alicia, additional, Pagano, Jodi L., additional, Alford, Chad M., additional, Bedwell, Noel W., additional, Hardy, Warren D., additional, DeAndrade, Kevin, additional, Elmore, Jessica G., additional, Auerbach, Eric, additional, Haney, Anthony W., additional, Brooks, Miriam H., additional, Torres, Jose, additional, Roper, Lois, additional, Backer, Terry, additional, Backer, Katie, additional, Evans, John G., additional, Silva, Ricardo A., additional, Dajani, Lorraine H., additional, Yousif, Veronica, additional, Ross, Tammy, additional, Roy, Sion K., additional, Oudiz, Ronald, additional, Hamal, Sajad, additional, Flores, Ferdinand, additional, Leahy, Amor, additional, Ayer, Debra, additional, George, Swapna, additional, Stewart, Chrisi Carine, additional, Orellana, Elvira, additional, Boccalandro, Cristina, additional, Rangel, Mary, additional, Hennings, Suzanne, additional, Vanselow, Carl, additional, Victor, Teri, additional, Birdwell, Darlene, additional, Haas, Paul, additional, Sandoval, Anthony, additional, Ciavarella, Gina, additional, Saglam, Caroline, additional, Bird, Amy, additional, Beck, Keith, additional, Poliquin, Brian, additional, Dominguez, David, additional, Tenorio, Brittany, additional, Perkins, Harvonya, additional, San Roman, Esther, additional, Bransford, Paris, additional, Lowrance, Christy, additional, Broussard, Marcy, additional, Ellis, Mary, additional, Skiles, Bobbi, additional, Hamilton, Jessica, additional, Hall, Kathryn, additional, Olvera, Diego, additional, Hartwell, Julee A., additional, Sorial, Nevien, additional, Rickman, Mary, additional, Berman, Kevin, additional, Mehta, Nirav, additional, Laborin, Annie, additional, Rothenberger, Rodger, additional, Beauvilliers, Sarah, additional, Morrell, Kathy, additional, Schachter, Michael P., additional, Perkins, Cindy L., additional, Gordon, Elizabeth A., additional, Lauer, Jennifer, additional, Bichsel, Kim, additional, Oliver, Kelly, additional, Mellor, Leslie J., additional, Demattia, Candice, additional, Schomburg, Jennifer, additional, Moreno, Yenniffer, additional, Mansur-Garza, Eduardo, additional, Rippstein, Lena, additional, Chacon, Lorie, additional, Pena, Andrea, additional, King, Michelle, additional, Richardson, Susan, additional, Jessop, Annette, additional, Tucker, Nicole, additional, Royer, Whitney, additional, Templeton, Gilbert, additional, Moell, Ann, additional, Weller, Christine, additional, Botts, Melissa J., additional, Hollon, Gretel, additional, Homberg-Pinassi, Elsa, additional, Forest, Paula, additional, Abhulhak, Aref Bin, additional, Chun-Furlong, Devona, additional, Harrington, Deborah, additional, Harlynn, Emily, additional, Schmitt, Marjorie, additional, Shelsky, Constance, additional, Feldick, Patricia, additional, Cherrico, Mary, additional, Jagle, Courtney, additional, Warnecke, Nicholas, additional, Myer, Debra, additional, Ruder, Deanna J., additional, Underwood, Albina, additional, Rauba, Alan, additional, Carr, George, additional, Oberhaus, Barbara, additional, Vanderfeltz, Jessica, additional, Stucky-Heil, Mary Jo, additional, Gibson, Dale R., additional, Fuentes, Vonnie, additional, Talbot, Kimberly L., additional, Simon, William C., additional, Grimes, Katlyn J., additional, Wheeler, Christina R., additional, Shultz, Cassaundra, additional, Metcalf, Rhonda A., additional, Hill, Jennifer L., additional, Oliver, Michelle R., additional, Ahmad, Basharat, additional, Azeem, Fouzal, additional, Rahim, Abdul, additional, Freeman, George H., additional, Bloch, Dawn, additional, Freeman, Heather, additional, Brown, Jamie, additional, Rosbach, Sarah, additional, Melander, Pamela, additional, Taralson, Nick, additional, Liu, Alex, additional, Harms, Katlyn, additional, Michale, Mahfouz, additional, Lopez, Jose, additional, Revoredo, Maria, additional, Edevane, Shari, additional, Shawley, Sarah, additional, Jackson, Timothy L., additional, Oliver, Michael J., additional, DeSalle, Dina, additional, Matlock, Patricia J., additional, Beraun, Ionna M., additional, Hendrix, Heather, additional, Bromley, Garrett, additional, Niemerski, Ashley, additional, Teran, Gabby, additional, Guerrero, Sonia, additional, Marvi, Murtaza, additional, Palanpurwala, Zehra, additional, Torres, Andrea, additional, Gloyd, Patty, additional, Conger, Michelle, additional, Laurent, Aziz, additional, Nayor, Olia, additional, Villanueva, Catalina S., additional, Khambati, Munira, additional, Mumford, Tabetha J., additional, Castillo, Melanie J., additional, Desta, Taddese, additional, Robinson, Jerome, additional, Woods, La Shawn, additional, Bahri, Anita, additional, Herrera, Nancy, additional, Casaclang, Cecilia, additional, Unger, Jeffrey R., additional, Martinez, Geraldine, additional, Moon, Mia K., additional, Mohaupt, Stephen M., additional, Sandoval, Larry, additional, Valenzuela, Louisito, additional, Ramirez, Victora, additional, Mata, Nelly, additional, Avila, Veronica, additional, Patino, Marisol, additional, Montano-Pereira, Cynthia, additional, Barnett, Omar, additional, Webster, William M., additional, Christensen, Lorraine M., additional, Bofman, Leighna, additional, Livingston, Melanie, additional, Adams, Stacey, additional, Hobbs, Joseph, additional, Koskela, Leesa, additional, Katz, Mia, additional, Mujica-Trenche, Samuel, additional, Cala, Franklin, additional, Rana, Noreen T., additional, Scarlett, Jennifer, additional, Cala Anaya, Milagros, additional, Jones, Marsha R., additional, Hollis, Kelly D., additional, Roth, Debbie, additional, Eads, Kristin, additional, Watts, Tina, additional, Perkins, Judy, additional, Arnold, Alice, additional, Ginsberg, Daniel C., additional, Quinn, Denise, additional, Cureton, Nicole, additional, Fittingoff, David B., additional, Iqbal, Mohammed I., additional, White, Stephen R., additional, Sisneros, Edith, additional, Ducca, Michelle, additional, Streja, David, additional, Campos, Danny, additional, Boak, Jennifer L., additional, Amir, Farzeen, additional, Anderson, Felice, additional, Kmetzo, James J., additional, Bongarzone, Mary O., additional, Scott, Dawn, additional, De Leon, Mary Grace, additional, Buda, Cynthia, additional, Graettinger, William, additional, Alex, Michelle, additional, Hess, Erika, additional, Govoni, James, additional, Bartel, Melissa, additional, Monchamp, Travis L., additional, Roach, Julie S., additional, Gibson, Sara, additional, Allfrey, Amy M., additional, Timpy, Kristen, additional, Bott, Kathy, additional, Soucy, Karin A., additional, Willis, Jean, additional, Valerio, Cecilia A., additional, Chunduri, Anusha, additional, Coker, Rebecca, additional, Vidrine, Nicole, additional, Thompson, Ellen A., additional, Studeny, Mark A., additional, Marcum, Melissa K., additional, Monway, Tammy S., additional, Kosmicki, Douglas L., additional, Kelley, Melissa J., additional, Godfrey, Corey M., additional, Krenk, Susan L., additional, Holcomb, Randy R., additional, Baehr, Deb K., additional, Trauernicht, Mary K., additional, Rowland Lowry, David, additional, Bondy Herts, Betty, additional, Phelps, Jeanne E, additional, Downing, Jean-Marie, additional, Gamer Dignon, Carol, additional, Cockrill, Elisabeth S., additional, Chapla, Pravinchandra G., additional, Fera, Diane, additional, Chang, Margaret, additional, Fredette, Patricia, additional, Ashby, Tamie, additional, Bergin, Renee, additional, Stearns, Zebediah A., additional, Ware, David B., additional, Boudreaux, Rachael M., additional, Rodriguez, Joanna, additional, McKenzie, Robert, additional, Huber, Amanda, additional, Sommers, Rebecca, additional, Rowe, Heather, additional, McLallen, Stacy, additional, Haynes, Michale, additional, Adamson, Ashley, additional, Henderson, Janice, additional, McClure, Lori, additional, Harris, Beverly A., additional, Ference, Laura, additional, Meissner-Dengler, Sue, additional, Treasure, Lisa, additional, Nicely, Doreen, additional, Light, Timothy L., additional, Osborn, Tracey A., additional, Mai, Kimberly J., additional, Vivas, Pablo, additional, Rios, Jose, additional, Rodriguez, Dunia, additional, DeRaad, Roger, additional, Walder, James, additional, Bailon, Oscar, additional, Hockett, Denice, additional, Anderson, Debbie, additional, McIntosh, Kelli, additional, Odegard, Amber, additional, Shepherd, Andrew, additional, Seifert, Mary, additional, Kelley, Laurence, additional, Shetty, Rajendra, additional, Castine, Michael, additional, Brill, David, additional, Fisher, Gregory, additional, Richmond, Nicole, additional, Gray, Kathleen, additional, Miller, Patricia, additional, Coneys, Charlene, additional, Chanza, Yarixa, additional, Sumoza, Monica, additional, Caudill, Victoria M., additional, Harris, Kelly D., additional, Manion, Courtney A., additional, Lineberger-Moore, Melody J., additional, Wolfe, Julie J., additional, Rosen, Barbara J., additional, DiVito, Patricia, additional, Moffat, Janet L., additional, Michaelis, Christina, additional, Koshy, Prashant, additional, Perea, Diana, additional, Al Yacoub, Ghaith, additional, Sadeghi, Stephanie, additional, LeGalley, Thomas D., additional, Evonich, Rudolph F., additional, Jean, William J., additional, Friesen, Gary M., additional, Pap, John M., additional, Pesola, David A., additional, Cowan, Mark D., additional, Dosh, Kristofer M., additional, Larson, Dianna, additional, Price, Adele M., additional, Nease, Jodi A., additional, Anderson, Jane E., additional, Piggott, Lori A., additional, Iwaoka, Robert, additional, Sharkey, Kevin, additional, McMillan, Edward, additional, Lowder, Laurie, additional, Morgan, Latisha, additional, Davis, Kyle, additional, Caldwell, Tara, additional, Breglio, Erica, additional, Summers, Jasmine, additional, Poulimas, Rachel, additional, Zahid, Muhammad, additional, Syed, Hamid, additional, Escobar, Maria, additional, Levy, Jacob, additional, Warsi, Rahma, additional, Ma, Carol, additional, Cen, Puxiao, additional, Cawthon, Kimberly A., additional, Barnes, Delores B., additional, Allen, Deanna G., additional, Warrington, Margaret L., additional, Stastny, Carol R., additional, Michaels, Robin J., additional, Saleh, Mohamad, additional, Sorin, John, additional, Rathod, Sunny, additional, Juett, Urakay, additional, Spencer, Steven, additional, Keval, Aziza, additional, McBride, Jill, additional, Young, Shane, additional, Baxter, Catherine, additional, Rasmussen, Carol, additional, Coxe, Shari L., additional, Campos, Luis, additional, Tavackoli, Shahin, additional, Beckham, Diana, additional, Sanchez, Darlynee, additional, Basrai, Karanjit, additional, Helms, Dorian, additional, Clinton, Erica, additional, Smith, Kasie, additional, Cusnir, Henry, additional, Klaus Clark, Mary, additional, Cherukuri, Madhavagopal V., additional, Scarfaru, Ameta, additional, Nash, Stephen D., additional, Grimm, Loretta C., additional, Grace, Anna, additional, McElheran, Kylie, additional, Subasic, Dino, additional, Buhay, Zedrick, additional, Litvinoff, Janet, additional, Shah, Deepak, additional, Cervantes, Shannon, additional, Usher, Freda, additional, Yasser, Farra, additional, Trusevich, Theodore, additional, Garcia, Ronnie L., additional, Wyatt, Jamison, additional, Bose, Rahul, additional, Miska, Holllilyn, additional, Spivey, Traci, additional, Wren, Amy B., additional, Vance, Katie E., additional, Holman, Lani L., additional, Gibbons, Pam, additional, Eby, Elaine, additional, Shepard, Sandra, additional, Charoenthongtrakul, Soratree, additional, Snodgrass, Brett, additional, Nazem, Mohammed, additional, Keteenburg, Shelly, additional, Murthy, Prathima, additional, Prater, Frederic, additional, Rumfelt, Ashley, additional, Eizensmits, Christina, additional, Iannuzzi, Lisa, additional, Patel, Pourus R., additional, Bergamino, Clellia, additional, McFeaters, Elizabeth, additional, Rizk, Botros, additional, Pflaum, Emiljia, additional, Kalish, Danny, additional, Ambatali, Rex, additional, Ameli, Mona, additional, Sanguinetti, Delaina, additional, Vaidya, Rakesh, additional, Broeders, Martinus A.W., additional, Henrikus, Dorman, additional, Kuijper, Adrianus F.M., additional, Al-Windy, Nadea, additional, Magro, Michael, additional, Hamraoui, Karim, additional, Aksoy, Ismail, additional, Vermeiren, Guy L.J., additional, Roeters van Lennep, H.W.O., additional, Hoedemaker, Gerard, additional, Remmen, Johannes Jacobus, additional, Bogaard, Kjell, additional, van der Heijden, Dirk, additional, Knufman, Nicole MJ, additional, Frederiks, Joost, additional, Louwerenburg, Johannes Willem, additional, van Rossum, Piet, additional, Milhous, Johannes, additional, van der Meer, Peter, additional, van der Weerdt, Arno, additional, Breedveld, Rob, additional, Keijzers, Mitran, additional, Hermans, Walter, additional, van de Wal, Ruud, additional, Zwart, Peter A.G., additional, van der Linden, Marc M.J.M., additional, Zwiers, Gerardus, additional, Boswijk, Dirk J., additional, Geert Tans, Jan, additional, van Eck, Jacob, additional, Hessen, Maarten V., additional, Hamer, Barnabas J.B., additional, Zoet-Nugteren, Stieneke, additional, Theunissen, Lucien, additional, van Beek, E.A., additional, Nijmeijer, Remco, additional, Nierop, Pieter R., additional, Linssen, Gerard, additional, Swart, H.P., additional, Lenderink, Timo, additional, Bartels, Gerard L., additional, den Hartog, Frank, additional, Berg van den, Brian J., additional, van Kempen, Wouter, additional, Kentgens, Susanne, additional, Rojas Lingan, Gloria M., additional, Peeters, Martinus M., additional, Keterberg, Hilligje, additional, Nierman, Melchior, additional, den Hollander, Annemieke K., additional, Hoogendijk, Jacqueline, additional, Voors-Pette, Christine, additional, Kose, Vicdan, additional, Viergever, Peter, additional, Yena, Larysa, additional, Syvolap, Viktor, additional, Kopytsya, Mykola P., additional, Barna, Olga, additional, Panina, Svitlana S., additional, Lutai, Mykhailo I., additional, Shershnyova, Oxana V., additional, Luzkiv, Iryna, additional, Bula, Larysa S., additional, Zotov, Sergii, additional, Vyjhovaniuk, Ivan, additional, Lysunets, Olena, additional, Koshlia, Volodymyr I., additional, Sydor, Nataliya, additional, Vayda, Myroslava F., additional, Ushakov, Olexiy, additional, Rishko, Mykola, additional, Shcherbak, Viktor P., additional, Svyshchenko, Yevgeniya, additional, Tseluyko, Vira, additional, Yagensky, Andriy, additional, Zolotaikina, Viktoriia I., additional, Godlevska, Olga, additional, Ivanova, Larysa, additional, Koval, Olena, additional, Mitchenko, Olena I., additional, Kardash, Galyna Y., additional, Rudyk, Yurii S., additional, Stanislavchuk, Mykola, additional, Ivanovych Volkov, Volodymyr, additional, Karlinskaya, Olena G., additional, Tykhonova, Susanna A., additional, Vatutin, Nikolay, additional, Smirnova, Ganna, additional, Kovalenko, Volodymyr M., additional, Lizogub, Viktor, additional, Sebov, Denys, additional, Dyadyk, Oleksandr, additional, Andrievskaya, Svetlana, additional, Krasko, Mykola P., additional, Parkhomenko, Alexander N., additional, Horbach, Lidiya, additional, Kupnovytska, Iryna G., additional, Pertseva, Tetyana, additional, Karpenko, Oleksandr, additional, Reshotko, Dmytro, additional, Zhurba, Svitlana V., additional, Rudenko, Leonid, additional, Yu Zharinova, Viktoriia, additional, Shatylo, Valerii B., additional, Karpenko, Yuriy I., additional, Orynchak, Mariya A., additional, Kameneva, Tatiana R., additional, Zherlitsina, Elena, additional, Alpenidze, Diana N., additional, Arutyunov, Grigoriy P., additional, Baranova, Elena, additional, Bart, Boris, additional, Belenkiy, Dmitriy I., additional, Boldueva, Svetlana A., additional, Demchenko, Elena A., additional, Eltishcheva, Vera V., additional, Gofman, Alexander M., additional, Goloshchekin, Boris M., additional, Gennadyevich Gordeev, Ivan, additional, Gratsianskiy, Nikolay, additional, Kamalov, Gadel, additional, Khasanov, Niyaz R., additional, Kholina, Irina M., additional, Kobalava, Zhanna D., additional, Kobeleva, Elena V., additional, Konradi, Alexandra O., additional, Kostenko, Victor A., additional, Dmitrievich Kuimov, Andrey, additional, Ermakova, Polina Y., additional, Malyutina, Sofia K., additional, Panov, Alexey V., additional, Polezhaeva, Natalia V., additional, Reshetko, Olga, additional, Shilkina, Nataliya P., additional, Shustov, Sergey B., additional, Smolyarchuk, Elena A., additional, Stryuk, Raisa I., additional, Yurievnar Solovieva, Elena, additional, Susekov, Andrey V., additional, Vezikova, Natalia, additional, Ivanova, Svetlana N., additional, Petrov, Alexander A., additional, Konstantinov, Vladimir O., additional, Agafina, Alina S., additional, Gurevich, Victor, additional, Zrazhevskiy, Konstantin N., additional, Supryadkina, Tatiana V., additional, Perepech, Nikita B., additional, Arkhipovskiy, Vadim L., additional, Yu Butko, Dmitry, additional, Zobenko, Irina A., additional, Orlikova, Olga V., additional, Mordovin, Viktor, additional, Barbarash, Olga L., additional, Lebedeva, Anastasiya, additional, Nosov, Vladimir, additional, Averkov, Oleg V., additional, Pavlikova, Elena P., additional, Karpov, Yuri B., additional, Lvovna Giorgadze, Marina, additional, Khrustalev, Oleg A., additional, Arkhipov, Mikhail, additional, Raskina, Tatiana A., additional, Shilko, Julia V., additional, Samoilova, Yulia, additional, Kosmacheva, Elena D., additional, Nedogoda, Sergey V., additional, Coetzee, Kathleen, additional, Burgess, Lesley J., additional, Theron, F.C.R., additional, Ebrahim, Iftikhar O., additional, Haasbroek, Gerbrand A., additional, Pretorius, Maria, additional, Trokis, Julien S., additional, Urbach, Dorothea V., additional, Abelson, Mark J., additional, Horak, Adrian R., additional, Badat, Aysha E., additional, Makotoko, Ellen M., additional, Du Toit Theron, Hendrik, additional, Ramlachan, Padaruth, additional, Corbett, Clive H., additional, Mitha, Ismail H., additional, Nortje, Hendrik F.M., additional, Jansen van Rensburg, Dirkie J., additional, Sebastian, Peter J., additional, Bester, F.C.J., additional, van Zyl, Louis J., additional, Rayner, Brian L., additional, Błach, Elżbieta, additional, Dąbrowska, Magda, additional, Kania, Grzegorz, additional, Kelm-Warchol, Agata E., additional, Kinasz, Leszek P., additional, Korecki, Janusz, additional, Kruk, Mariusz, additional, Laskowska-Derlaga, Ewa, additional, Madej, Andrzej, additional, Saminski, Krzysztof, additional, Wasilewska, Katarzyna, additional, Szymkowiak, Katarzyna, additional, Wojciechowska, Małgorzata, additional, Piorowska, Natalia, additional, Dyczek, Andrzej, additional, Abhaichand, Rajpal K., additional, Byrapaneni, Ramesh B., additional, Hattur, Basavanagowdappa, additional, Bhaskara Rao, Malipeddi, additional, Ghaisas, Nitin, additional, Shankar Kadam, Sujit, additional, Gupta, Jugal B., additional, Jayadev, Santhosh M., additional, Kothiwale, V.A., additional, Mathur, Atul, additional, Bhaskar, Vijay, additional, Aluri, Ravi K., additional, Ponangi, Udaya P., additional, Sarna, Mukesh K., additional, Sathe, Sunil, additional, Sharma, Manish K., additional, Singh Sawhney, Jilendra Pal, additional, Keshavamurthy, Chakrabhavi B., additional, Srinivas, Arun, additional, Thacker, Hemant P., additional, Sharda, A., additional, Joseph, Johny, additional, Dwivedi, Sunil, additional, Mohan, Viswanathan, additional, Premchand, Rajendra K., additional, Bedard, Jacques, additional, Bergeron, Jean, additional, Collette, Ronald, additional, Crowley, David, additional, Dumas, Richard, additional, Henein, Sam, additional, Moran, Geoff, additional, O’Mahony, William F., additional, O’Mahony, Michael, additional, Chan, Sammy, additional, Sherman, Mark H., additional, Wong, Graham C., additional, Carlson, Brian D., additional, Gupta, Milan K., additional, Borts, David, additional, Peterson, Sean R., additional, Chilvers, Martyn, additional, Kelly, Allan J., additional, Gregoire, Jean C., additional, Kouz, Simon, additional, Rodés Cabau, Josep, additional, Andor, Minodora, additional, Cinteza, Mircea, additional, Ciudin, Radu, additional, Cojan, Radu I., additional, Darabont, Roxana O., additional, Dumitrascu, Dan-Lucian, additional, Fierbinteanu-Braticievici, Carmen, additional, Fruntelata, Ana Gabriela, additional, Militaru, Constantin, additional, Minescu, Bogdon E., additional, Luminita Serban, Doina, additional, Mitu, Florin, additional, Nastase Melicovici, Dorel, additional, Petrascu, Ovidiu, additional, Pirvu, Octavian M., additional, Podoleanu, Cristian, additional, Pop, Calin, additional, Stanescu-Cioranu, Rodica-Valentina V., additional, Tase, Adrian, additional, Voiculet, Cristina, additional, Aroney, Constantine N., additional, Dart, Anthony M., additional, Davis, Timothy, additional, Kostner, Karam, additional, O’Neal, David N., additional, Purnell, Peter W., additional, Singh, Bhuwanendu B., additional, Sullivan, David R., additional, Thompson, Peter, additional, Watts, Gerald F., additional, Blenkhorn, Adam F., additional, Amerena, John V., additional, Samie, Rafeeq, additional, Hendriks, Randall, additional, Proietto, Joseph, additional, Petrovsky, Nikolai, additional, Whelan, Alan, additional, Colquhoun, David, additional, Scott, Russell S., additional, Young, Simon C., additional, Pegg, Tammy, additional, Wilson, Samuel JS, additional, Hamer, Andrew W., additional, Luke, Richard A., additional, Hart, Hamish H., additional, Devlin, Gerard P., additional, Wilkins, Gerard T., additional, Ternouth, Ian F., additional, Nandra, Samraj, additional, Loeprich, Bruno S., additional, McGrath, Nicole, additional, Tie, Stuart L., additional, Bos, Rob J., additional, Wils, Alexandra, additional, Jacobs, Tamara, additional, Badings, Erik A., additional, Ebels-Tuinbeek, Lillian A., additional, Scholten, Mayke L., additional, Bayraktar-Verver, Esther, additional, Zweers, Debby, additional, Schiks, Manoek, additional, Kalkman, Carolien, additional, Tiemes, Tineke, additional, Mulderij, Jeanette, additional, Dabrowska, Katarzyna, additional, Wijnakker, Wilma, additional, Van de Loo, Riny, additional, de Graauw, Jeanne, additional, Reijnierse, Giny, additional, van der Zeijst, Mirjam, additional, Scholten, Mariska, additional, Hofmeijer, Henk R., additional, van Dijk-van der Zanden, Antoinette, additional, van Belle, Dineke J., additional, Van Es, Jan, additional, Van Buchem, Gera, additional, Zijda, Wendy, additional, Verheij, Harald, additional, Oldenhof-Janssen, Linnea, additional, Bader, Martina, additional, Löwik, Marije, additional, Stuij, Sandra, additional, Vantrimpont, Pascal, additional, van Aken, Krista, additional, Hamilton, Karen, additional, Blömer, Han, additional, van Laerhoven, Gabriela, additional, Tukkie, Raymond, additional, Janssen, Maarten, additional, Verdel, Gerard, additional, Funke Küpper, Jon, additional, van Vlies, Bob, additional, Kalkman, Caroline, additional, Vooges, Joke, additional, Vermaas, Marinella, additional, Langenberg, Rachel, additional, Haenen, Niek, additional, Smeets, Frans, additional, Scheepmaker, Arko, additional, Grosfeld, Marcel, additional, Van Lieshout, Ilvy, additional, van den Berg, Marleen, additional, Wittekoek, Marian, additional, Mol, Petra, additional, Stapel, Antionette, additional, Sierevogel, Margaretha, additional, van der Ven, Nancy, additional, Berkelmans, Annemiek, additional, Viergever, Eric, additional, Kramer, Hanneke, additional, Engelen, Wilma, additional, Houwelingen, Karen V., additional, Wildbergh, Thierry X., additional, Mosterd, Arend, additional, Hobé-Rap, Coriet, additional, van Doorn, Marjan, additional, Bunschoten, Petra, additional, Freericks, Michel, additional, Emans, Mireille, additional, Den Boer-Penning, Petra, additional, Verlek, Els, additional, Freericks, Christine, additional, de Nooijer, Cornelis, additional, Welten, Christina, additional, Groenenberg, Ingrid, additional, van der Horst, Claudia, additional, Vonk, Esther, additional, Tjeerdsma, Geert, additional, Jochemsen, Gerard M., additional, van Daalen, Corinne, additional, Danse, Ingrid Y., additional, Kuipers, Lucy, additional, Pieterse, Anke, additional, Oomen, Antonius, additional, de Waard, Daan, additional, Jan Flu, Willem, additional, Kromhout, Zusan, additional, Van der Bij, Petra, additional, Feld, Rob, additional, Hessels-Linnemeijer, Brigitta, additional, Lardinois, Rob, additional, Posma, Jan L., additional, Aukema-Wouda, Zwanette R., additional, Hendriks-van Woerden, Marjolijn, additional, van Wijk, Desiree, additional, Beelen, Driek P., additional, Hendriks, Ingrid H., additional, Jonker, Jan J., additional, Schipperen, Stefanie, additional, Köse, Vicdan, additional, Rojas, Gloria, additional, Goedhart, Linda, additional, van Meurs, Hanneke, additional, Rijssemus, Jacqueline, additional, Swinkels-Diepenmaat, Lindy, additional, de Louw-Jansen, Marloes, additional, Bierens-Peters, Dominique, additional, van Kempen, Willem W., additional, Wittekoek, Marianne E., additional, Agous, Irmaina, additional, Schenk, Geert, additional, Wittekoek, Janneke, additional, Cox, Kevin, additional, Julia, Deborah F., additional, Jonker, Jan J.C., additional, Janssen, Roel, additional, Nierman, Melchor, additional, Katerberg, Hilligje, additional, van der Haar, Irene, additional, Van Kempen, Willem W., additional, van Mesdag, Taco, additional, Alvarez Costa, Leyda M., additional, Schensema, Manon, additional, Zweekhorst, Salomé, additional, Font Julia, Deborah, additional, Hanewinckel, Lauri, additional, Olsthoorn, Joyce, additional, Berends, Johan C., additional, van der Spek, Arie C., additional, van der Berg, Roy, additional, Timmermann, Rob J., additional, Boerema, Ingrid, additional, Mudruk, Iryna, additional, Khrystoforova, Anna, additional, Kyselov, Serhii, additional, Hilova, Yaroslava V., additional, Logoida, Pavlo, additional, Sanina, Nataliia A., additional, Golikova, Ilona P., additional, Nemchyna, Olena O., additional, Isaichikov, Ivan I., additional, Potapova, Olga B., additional, Gura, Iurii V., additional, Berestetska, Larysa, additional, Kulianda, Olena O., additional, Tantsura, Oleksandr, additional, Kulbachuk, Oleksandr S., additional, Petsentiy, Volodymyr, additional, Biskub, Ihor, additional, Handych, Tetyana, additional, Lagkuti, Oleg, additional, Gagarina, Alyna, additional, Chendey, Taras, additional, Bilonko, Oksana F., additional, Matova, Olena, additional, Bezrodna, Larysa, additional, Yarynkina, Olena, additional, Ovdiienko, Tetiana, additional, Randchenko, Volodymyr, additional, Mospan, Maryna, additional, Butko, Olena, additional, Romanenko, Olga, additional, Pavelko, Mykhailo, additional, Sichkaruk, Iryna, additional, Lazareva, Svitlana O., additional, Kudryk, Olena A., additional, Koltsun, Inessa M., additional, Magdalits, Tetiana, additional, Zadorozhniy, Sergei, additional, Kompaniiets, Kira, additional, Ivanov, Andrii, additional, Romanenko, Sergiy, additional, Kaplan, Pavlo, additional, Romanov, Vadym Y., additional, Mykytyuk, Oksana P., additional, Zaitseva, Nataliia S., additional, Pyvovar, Sergiy N., additional, Burdeuna, Lyudmyla, additional, Serdobinska, Emerita, additional, Shevchenko, Tatiana I., additional, Ivanytskyi, Igor I., additional, Khyzhnyak, Olena V., additional, Kalinkina, Nataliya, additional, Keting, Olena, additional, Sklyanna, Olena, additional, Kashanska, Olga, additional, Shevelok, Anna, additional, Khristichenko, Marina, additional, Titov, Ievgenii Y., additional, Oleksander, Danilenko O., additional, Polenova, Nataliia S., additional, Altunina, Nataliia, additional, Kororaieva, Viktoriia, additional, Zborovskiy, Stanislav, additional, Kholopov, Leonid, additional, Suliman, Iurii, additional, Lukashenko, Lanna, additional, Shvaykin, Stanislav, additional, Glavatskiy, Olexandr M., additional, Sychov, Roman O., additional, Kulynych, Roman L., additional, Skarzhevskyi, Oleksandr A., additional, Dovgan, Nataliia V., additional, Horbach, Marta, additional, Cherkasova, Olga, additional, Tyshchenko, Iryna, additional, Todoriuk, Liudmyla, additional, Kizim, Svitlana, additional, Brodi, Nataliia, additional, Ivanko, Oleksandr, additional, Garbarchuk, Olga, additional, Alieksieieva, Liudmyla, additional, Shandra, Tetiana L., additional, Beregova, Olena, additional, Bodretska, Larisa An, additional, Naskalova, Svitlana S., additional, Antoniuk-Shcheglova, Ivanna A., additional, Bondarenko, Olena V., additional, Andreeva, Natalia G., additional, Vakalyuk, Iryna I., additional, Chovganyuk, Olha S., additional, Artemenko, Nataliya R., additional, Maltsev, Kiril A., additional, Kalishevich, Natalia, additional, Kondratyeva, Natalia G., additional, Nikitina, Svetlana A., additional, Martjanova, Maria V., additional, Sokolova, Anna V., additional, Dragunov, Dmitrii O., additional, Kolesnik, Olga, additional, Larina, Vera, additional, Tsygankova, Oxana V., additional, Ivanova, Maria, additional, Karpov, Illia A., additional, Aronova, Elena M., additional, Vedernikova, Ekaterina S., additional, Lubinskaya, Ekaterina I., additional, Burak, Taras Y., additional, Skichko, Sergey I., additional, Rasulev, Farhad, additional, Soldatova, Ekaterina B., additional, Fenin, Alexander L., additional, Laptev, Ilya I., additional, Luchinkina, Elena E., additional, Akatov, Alexandr, additional, Polenova, Natalia V., additional, Slavina, Natalia N., additional, Korovnika, Irina N., additional, Yu Prochorova, Marina, additional, Shakirova, Regina, additional, Andreicheva, Elena N., additional, Krasnova, Olga A., additional, Lobzhanidze, Tinatin V., additional, Dmitrova, Tatiana B., additional, Stakhiv, Viktoriya V., additional, Pechatnikova, Maria I., additional, Panova, Alexandra V., additional, Tipikina, Maria Y., additional, Rotar, Oxana P., additional, Bokovin, Nikolay A., additional, Karabalieva, Saule K., additional, Tumarov, Farid Y., additional, Vasileva, Elena V., additional, Gennadevna Lozhkina, Natalya, additional, Filippova, Ekaterina V., additional, Sharkaeva, Alisa I., additional, Filippova Deilik, Ekanerina V., additional, Yu Tolkacheva, Natalia, additional, Domracheva, Elena N., additional, Ryabikov, Andrey N., additional, Abesadze, Inga T., additional, Alugishvili, Marianna Z., additional, Nikolaeva, Elena P., additional, Smirnova, Nadezda V., additional, Rodionova, Valentina I., additional, Dolovstaya, Polina V., additional, Yunonin, Igor E., additional, Kadin, Sergey V., additional, Sveklina, Tatyana S., additional, Bushmanova, Anna V., additional, Barkova, Elena L., additional, Gomova, Irina S., additional, Brytkova, Yana V., additional, Ivanova, Tatiana B., additional, Zubareva, Marina Y., additional, Skopets, Inga, additional, Galashevskaya, Lybov A., additional, Butinskaya, Emilia D., additional, Gusarova, Olga G., additional, Kalishevich, Natalia B., additional, Pavlova, Yana R., additional, Serebrenitskaya, Marianna P, additional, Grygorieva, Vitalina F., additional, Kuchaeva, Gulnara R., additional, Vasileva, Inna A., additional, Ospanova, Gulnara I., additional, Vahrusheva, Yulia V., additional, Semenova, Irina A., additional, Mikhailova, Irina E.E., additional, Kvasova, Olga O., additional, Shurygina, Valeria D., additional, Rivin, Alexey E., additional, Savelyev, Alexey O., additional, Savelyev, Alexey A., additional, Milyaeva, Olesya O., additional, Lapshina, Nadezhda N., additional, Lantsova, Ninel A., additional, Alexandrov, Pavel V., additional, Orlikov, Evgeniy A., additional, Falkovskaya, Alla, additional, Ripp, Tatiana, additional, Triss, Sergei, additional, Pekarskiy, Stanislav, additional, Ekaterina, Sitkova, additional, Zhuravleva, Evgeniya N., additional, Perova, Olga, additional, Kovaleva, Galina, additional, Koroleva, Liubov, additional, Mishchenko, Lydia, additional, Garshin, Boris P., additional, Kutuzova, Svetlana A., additional, Provotorova, Lyudmila I., additional, Zadvorny, Igor P., additional, Okhapkina, Olga V., additional, Khrustalev, Anatoly O., additional, Suvorova, Tatiana, additional, Shaf, Elena S., additional, Vershinina, Varvara A., additional, Kozulin, Andrey A., additional, Oleynik, Oxana A., additional, Martynova, Irina Y., additional, Kizhvatova, Natalia V., additional, Salasyuk, Alla S., additional, Tsoma, Vera V., additional, Ledyaeva, Alla A., additional, Chumachek, Elena V., additional, Blignaut, S.C., additional, Alexander, Tersia Y., additional, Du Plessis, Chano, additional, Govender, Thirumani, additional, Du Toit, Samatha M., additional, Motala, Leya, additional, Gassiep, Areesh, additional, Naude (Smit), Christina, additional, Terblanche, Marli, additional, Snoer (Kruger), Marlien, additional, Pillay, Berenice, additional, Basson, De Vries, additional, Theron, Marisa E., additional, Fouche, Bianca, additional, Coetzee, Mareli E., additional, Odendall, Pieter, additional, Van Wijk, Frederik H., additional, Conradie, Anna-Mari, additional, Van der Westhuizen, Trudie, additional, Tredoux, Carine, additional, Mookdam, Mohamed S., additional, Van der Merwe, Andie J., additional, Snyman, Karin, additional, Smal, Gerda, additional, De Jager, Yvonne, additional, Mabin, Thomas A., additional, King, Annusca, additional, Henley, Lindy L., additional, Zwane, Brenda M., additional, Robinson, Jane, additional, Karsten, Marinda, additional, Page, Andonia M., additional, Nsabiyumva, Valerie, additional, Krahenbuhl, Charmaine, additional, Patel, Jaiprakash D., additional, Motala, Yunus E., additional, Dawood, Ayesha, additional, Koza, Nondumiso B., additional, Peters, Lenore M.S., additional, Ramlachan, Shavashni, additional, Bodenstein, Wilhelm J., additional, Roux, Pierre, additional, Fouche, Lizelle, additional, Boshoff, Cecilia M., additional, Mitha, Haroon M., additional, Khan, Fathima, additional, Cyster, Henry P., additional, Cyster, Helen, additional, Wessels, E. C., additional, Jacobs, Florence J., additional, Sebastian, Melanie A., additional, Sebastian, Deborah A., additional, Mahomed, Nadia, additional, Immink, Ignatius P., additional, Cotzee, Celia, additional, Cronje, Tanja, additional, Roscher, Madele, additional, Le Roux, Maria, additional, Trinder, Yvonne A., additional, Wnętrzak-Michalska, Renata, additional, Piszczek, Magdalena, additional, Piela, Andrzej, additional, Czernecka, Ewa, additional, Knychas, Dorota, additional, Walczak, Alina, additional, Gładysz, Izabella, additional, Filas, Katarzyna, additional, Kiluk, Ewelina, additional, Świgło, Krzysztof, additional, Jędrzejczyk, Iwona, additional, Łuczyńska, Kamila, additional, Tymendorf, Katarzyna, additional, Piesiewicz, Wojciech, additional, Kinasz, Wojciech L., additional, Samborski, Stefan, additional, Bartuś, Ilona, additional, Latocha Korecka, Gramzyna, additional, Gulaj, Ewa, additional, Sopa, Jolanta, additional, Derlaga, Bogusław, additional, Baisiak, Marcin, additional, Kowalisko, Allicia, additional, Stainszewska-Marasazlek, Edyta, additional, Szafran, Bartosz, additional, Swiatkiewicz, Malgorzata, additional, Racewicz, Artur, additional, Grycel, Sławomir, additional, Supronik, Jerzy, additional, Walendziuk, Sylwia, additional, Tarantowicz, Magdalena, additional, Stasiak, Agata, additional, Sidorowicz-Białynicka, Anna, additional, Dwojak, Marek, additional, Jaźwińska-Tarnawska, Ewa, additional, Kupczyk, Katarzyna, additional, Martowska, Kamila, additional, Kulon, Kamila, additional, Gajda, Katarzyna, additional, Wilson, Bivin, additional, Velusamy, Krithika, additional, Sadhiq, Swaidha S., additional, Siddeshi, Bhavani, additional, Bhanukumar, M., additional, Srivatsav, Abhishek, additional, Ramesh, Madhan, additional, Harsha Chalasani, Sri, additional, Johnson, Mini, additional, Gopu, Prashanth, additional, George, Jeesa, additional, Reddy, Sowmya, additional, Thara Eleena, Swetha Tessy, additional, Rao Kodem, Damodara, additional, Nakkella, Haritha N., additional, Kumari Mandula, Padma, additional, Kumar Vuriya, Anjan, additional, Rajana, Syamala, additional, Kale, Aruna, additional, Rajeev, Tiwari, additional, Jain, Raina, additional, Jain, Vipin, additional, Mandayam Adhyapak, Srilakshmi, additional, Sheeba, Lumin, additional, C R, Uma, additional, R, Ramya, additional, Kulkarni, Aditya V., additional, Ganachari, M.S., additional, Sambrekar, Ruma, additional, Bilal, Mohammad, additional, Chakravarthy, Kalyan, additional, Badhavath, Ravi, additional, Kumar, Sravan, additional, Simhadri, Meenakshi, additional, Salamuddin, Farooque, additional, Prasad, Venkat, additional, Dwivedi, Vivek, additional, Sarna, Sudha, additional, Arora, Tilak, additional, Chawla, Deepak, additional, Sathe, Archana, additional, Gayatree, Chaware, additional, Nanda, Ajeet, additional, Avtar, Ram, additional, Sharma, Jyoti, additional, P S, Vaibhavi, additional, D, Sasirekha, additional, Kobbajji, Deepthi, additional, Ningappa, Ramya, additional, Shree, Shwetha, additional, K, Chandrashekar, additional, M R, Nandini, additional, S, Sowjanya, additional, I G, Devika, additional, N, Yashaswini, additional, G, Sonika, additional, L, Rathna, additional, R, Priyanka, additional, Shrimanker, Rupal J., additional, Vinutha Reddy, Lakshmi, additional, Sumathi, K., additional, Devi, Babitha, additional, Naik, Bina N., additional, Manjunath, Rohini, additional, Ashok, Rajeshwari, additional, Kunjumon, Tony V., additional, Thomas, Jesline, additional, Samdhani, Shaik, additional, Selvam, Kasthuri, additional, Subramani, Poongothai, additional, Parthasarathy, Nandakumar, additional, Bohra, Nirmal K., additional, Gatla, Anvesh K., additional, Horbatuk, Cheryl, additional, Sills, Julie, additional, Davey, E B., additional, Paramonczyk, Liz, additional, Racanelli, Olga, additional, Strybosch, Sandy, additional, Belanger, Andre, additional, Palardy, Jean, additional, Schiffrin, Alicia, additional, Gauthier, Sylvie, additional, Kalyniuk, Norman, additional, Whatley, Shawn D., additional, Lappala, Heather, additional, Patel, Grishma, additional, Reeve, Matthew, additional, Moran, Catherine, additional, Everitt, Jody, additional, Ferrari, Teresa, additional, Bouffard, Christine, additional, Frohlich, Jirir, additional, Francis, Gordon, additional, Mancini, John, additional, Bondy, Gregory, additional, DeAngelis, Debbie, additional, Fulton, Patricia, additional, Blank, David W., additional, Lombardo, Angela, additional, Roy, Mylène, additional, Chow, Jackie, additional, Fox, Hyman, additional, Grootendorst, William J., additional, Hutchinson, Angela, additional, Chan, Sharon M., additional, Fitzgerald, Christie, additional, Wilkins, Lynn, additional, Raymond, Rebecca L., additional, Reyes, Arlene, additional, Marc André, Lavoie, additional, Fortin, Denis, additional, Ouimet, Hélène, additional, Tôn-Nu, Thanh-Thao, additional, Dussureault, Martine, additional, Blain, Marie-Hélène, additional, Roy, Madeleine, additional, Kopajko, Nathalie, additional, Fleury, Chantal, additional, Maheux, Karine, additional, Ciobotaru, Gabriela Valentina, additional, Constantinescu, Maria C., additional, Gherghinescu, Carmen-Lucia, additional, Avram, Ana-Maria, additional, Manitiu, Ioan, additional, Sinpetrean, Aura, additional, Pop, Lucian, additional, Lupu, Delia, additional, Usvat, Radu, additional, Petrisor, Ana, additional, Dumitru, Nicoleta, additional, Moruju, Camelia, additional, Gheorghita, Adelina, additional, Mitu, Magda V., additional, Macarie, Cosmin, additional, Pop, Ana Maria, additional, Diaconu, Maria-Catalina, additional, Grancea, Iulia, additional, Cosma, Mihaela, additional, Crisan, Mihaela, additional, Herron, Elizabeth, additional, Nestel, Paul, additional, Kay, Sally B., additional, Carter, Kaye S., additional, Badshah, Imran, additional, Makepeace, Ashley, additional, Drinkwater, Jocelyn, additional, England, Michelle, additional, Rafei, Azette, additional, Patterson, Kylie, additional, Jenkins, Alicia, additional, McAuley, Sybil, additional, Kent, Sue M., additional, Vibert, Joy E., additional, Perrett, Leonie, additional, David, Thomas, additional, Kaye, Samantha L., additional, O’Connor, Monika, additional, Perera, Nimalie J., additional, Lai, Nicole T., additional, Kearins, Kerry A., additional, Dicamillo, Christinia, additional, Anderson, Heather, additional, Ferguson, Louise, additional, Radtke, Sharon D., additional, Thamarappillil, Charles T., additional, Boys, Janice M., additional, Long, Anita K., additional, Shanahan, Toni, additional, Nyguyen, Michael, additional, Forrest, Nicole, additional, Tulloch, Gill, additional, Greenwell, Della, additional, Price, Sarah L., additional, Tint, Aye N., additional, Sumithran, Priya K., additional, Debreceni, Tamara L., additional, Walker, Lisa, additional, Caruana, Mary, additional, Edwards, Kira, additional, Stathopoulos, Maria, additional, Haywood, Cilla, additional, Sajkov, Dimitar, additional, Pringle, Sharen, additional, Tabner, Anne, additional, Bartolay, Kathrina, additional, Abeyratne, Chamindi, additional, Bragg, Kylie, additional, Mulhern, Patrick, additional, Purnell, Peter, additional, Williams, Lyn, additional, Hamlyn, Jane, additional, Connelly, Aurelia, additional, Hoffman, Jan, additional, Bailey, Samantha, additional, Kerr, Jane, additional, Morrison, Zarnia, additional, Maeder, Sarah, additional, McEwan, Roberta, additional, Kunasekera, Prasanna, additional, McGregor, Patrice, additional, Young, Jo, additional, Berry, Sharon, additional, Cutfield, Rick, additional, Choe, Michelle, additional, McNamara, Catherine, additional, Shergill, Narrinder K., additional, Crone, Petra, additional, Williams, Miles G., additional, Dyson, Keith, additional, Schmid, Diana H., additional, Doak, Audrey C., additional, Spooner, Melissa, additional, Edwards, Colin, additional, Turner, Anne, additional, McAnnalley, Grainne M., additional, Fisher, Raewyn A., additional, Hamilton, Fraser B., additional, Friedlander, Denis H., additional, Kirk, Melissa R., additional, Scales, Jayne E., additional, McLelland, Marguerite A., additional, Dalman, Neelam A., additional, Vickers, Cathy E., additional, Jackson, Carolyn, additional, Coleman, Wendy, additional, Garden, Phillip I., additional, and Arnold, Wendy F., additional

Published
2021
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44. A Case Report: Euglycemic Diabetic Ketoacidosis Presenting as Chest Pain in a Patient on a Low Carbohydrate Diet

Author

Jonathan D. Newman, Melissa Sum, Brenda Dorcely, Arthur Schwartzbard, Juliana Nitis, and Ira J. Goldberg

Subjects
Acute coronary syndrome, Diabetic ketoacidosis, business.industry, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Metabolic acidosis, Type 2 diabetes, 030204 cardiovascular system & hematology, Chest pain, medicine.disease, Article, Ketoacidosis, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Anesthesia, Diabetes mellitus, Medicine, medicine.symptom, business
Abstract

Introduction: Sodium-glucose cotransporter-2 [SGLT2] inhibitors reduce cardiovascular events and mortality in patients with diabetes, particularly patients with established cardiovascular disease. Euglycemic diabetic ketoacidosis [euDKA], a complication of SGLT2 therapy, can be exacerbated by a low carbohydrate diet. Case Report: A 61-year-old man with a history of type 2 diabetes, taking an SGLT2 inhibitor empagliflozin 10 mg orally daily, presented to the emergency room with a 2-day history of nausea and chest pain. A week prior to presentation, he had started a ketogenic diet. He was initially admitted with a diagnosis of acute coronary syndrome. On initial assessment in the emergency room, his cardiac enzymes were normal and there were no ischemic changes in his ECG. As there was concern for unstable angina, he underwent cardiac catheterization, which showed a known total occlusion with collaterals and arteries with a non-obstructive disease without any evidence of acute plaque rupture. His baseline laboratory assessments revealed an elevated anion gap of 17, increased urinary and plasma ketones, and metabolic acidosis. His plasma glucose level was 84 mg/dL. The diagnosis of euDKA was made, and treatment with intravenous fluids and insulin was initiated. His chest pain and nausea subsequently resolved. Conclusion: We present a case of euDKA triggered by a ketogenic diet while on SGLT2 inhibitor therapy presenting as chest pain. The recognition of euDKA is important in the context of increased SGLT2 use for the management of cardiovascular risk for patients with diabetes.

Published
2021

47. Physicians’ Dietary Knowledge, Attitudes, and Counseling Practices: The Experience of a Single Health Care Center at Changing the Landscape for Dietary Education

Author

Arthur Schwartzbard, Jeffrey S. Berger, Emily A. Johnston, Tony Mathews, Eugenia Gianos, Nicole Harkin, and Yu Guo

Subjects
Response rate (survey), medicine.medical_specialty, business.industry, Health Policy, Nutrition Education, Public Health, Environmental and Occupational Health, Medicine (miscellaneous), 030209 endocrinology & metabolism, Disease, 03 medical and health sciences, 0302 clinical medicine, Continuing medical education, Family medicine, Lifestyle change, Preparedness, Health care, Nutritional knowledge, medicine, 030212 general & internal medicine, business, Original Research
Abstract

Morbidity and mortality associated with cardiovascular disease can be significantly modified through lifestyle interventions, yet there is little emphasis on nutrition and lifestyle in medical education. Improving nutrition education for future physicians would likely lead to improved preparedness to counsel patients on lifestyle interventions. An online anonymous survey of medical residents, cardiology fellows, and faculty in Internal Medicine and Cardiology was conducted at New York University Langone Health assessing basic nutritional knowledge, self-reported attitudes and practices. A total of 248 physicians responded (26.7% response rate). Nutrition knowledge was fair, but few (13.5%) felt adequately trained to discuss nutrition with patients. A majority (78.4%) agreed that additional training in nutrition would allow them to provide better clinical care. Based on survey responses, a dedicated continuing medical education (CME) conference was developed to improve knowledge and lifestyle counseling skills of healthcare providers. In postconference evaluations, attendees reported improved knowledge of evidence-based lifestyle interventions. Most noted that they would prescribe a Mediterranean or plant-based diet and would make changes to their practice based on the conference. An annual CME conference on diet and lifestyle can effectively help interested providers overcome barriers to lifestyle change in clinical practice through improved nutrition knowledge.

Published
2018
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48. The Changing Landscape of Diabetes Therapy for Cardiovascular Risk Reduction

Author

Jose O. Aleman, Arthur Schwartzbard, Jonathan D. Newman, Anish Vani, Jeffrey S. Berger, and Howard Weintraub

Subjects
medicine.medical_specialty, endocrine system diseases, business.industry, nutritional and metabolic diseases, Disease, Type 2 diabetes, 030204 cardiovascular system & hematology, medicine.disease, Diabetes Therapy, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, Heart failure, Primary prevention, medicine, 030212 general & internal medicine, Risk factor, Cardiology and Cardiovascular Medicine, Intensive care medicine, business, Glycemic
Abstract

Type 2 diabetes mellitus (T2D) is a major risk factor for cardiovascular disease (CVD), the most common cause of death in T2D. Despite improved risk factor control, however, adults with T2D continue to experience substantial excess CVD risk. Until recently, however, improved glycemic control has not been associated with robust macrovascular benefit. The advent of 2 new classes of antihyperglycemic agents, the sodium-glucose cotransporter-2 inhibitors and the glucagon-like peptide-1 receptor agonists, and their respective large cardiovascular outcome trials, has led to a paradigm shift in how cardiologists and heath care practitioners conceptualize T2D treatment. Herein, the authors review the recent trial evidence, the potential mechanisms of action of the sodium-glucose cotransporter-2 inhibitors and the glucagon-like peptide-1 receptor agonists, safety concerns, and their use for the primary prevention of CVD as well as in diabetic patients with impaired renal function and heart failure.

Published
2018
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