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31 results on '"Schwaiger, Theresa"'

1. The Reflective Fostering Programme—Adapting a group parenting programme for online delivery in response to the COVID‐19 pandemic in the United Kingdom.

Author

Redfern, Sheila, Pursch, Benita, Katangwe‐Chigamba, Thando, Sopp, Rumour, Irvine, Karen, Sprecher, Eva A., Schwaiger, Theresa, and Midgley, Nick

Subjects
MENTALIZATION, QUALITATIVE research, PARENTING education, EVALUATION of human services programs, PRIVACY, PILOT projects, FOSTER home care, GROUP psychotherapy, FOSTER parents, PSYCHOLOGICAL adaptation, REFLECTION (Philosophy), ONLINE education, PSYCHOLOGY of caregivers, COVID-19 pandemic, PSYCHOSOCIAL factors, GROUP process, MEDICAL ethics, CAREGIVER attitudes, ADVERSE childhood experiences
Abstract

Objective: In the context of the Covid‐19 pandemic and subsequent lockdown restrictions, service providers faced significant challenges in delivering programmes to support their vulnerable service users. Foster carers‐an already often isolated group of caregivers ‐ were offered an adapted remote‐delivery model of the Reflective Fostering Programme (Redfern et al., Adopt. Foster., 42, 2018, 234) from March 2020. Method: This paper outlines the adaptation process of the original programme to online‐remote delivery and describes the feedback from participants in the programme. Results: The adaptation of the Reflective Fostering programme to online, remote delivery had both strengths and weaknesses ‐ including wider access to foster carers who might struggle to attend in person and challenge a to maintaining a Mentalizing space online and ensuring confidentiality within a therapeutic space. The programme was overwhelmingly well received by foster carers in this format. Conclusions: There are opportunities and challenges in the delivery of online therapeutic services, particularly those with a group format. This paper contributes initial reflections to what we hope will be a rapidly developing literature on best practice of supporting group services in an online format. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Archaeome structure and function of the intestinal tract in healthy and H1N1 infected swine

Author

Meene, Alexander, primary, Gierse, Laurin, additional, Schwaiger, Theresa, additional, Karte, Claudia, additional, Schröder, Charlotte, additional, Höper, Dirk, additional, Wang, Haitao, additional, Groß, Verena, additional, Wünsche, Christine, additional, Mücke, Pierre, additional, Kreikemeyer, Bernd, additional, Beer, Martin, additional, Becher, Dörte, additional, Mettenleiter, Thomas C., additional, Riedel, Katharina, additional, and Urich, Tim, additional

Published
2023
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7. Application of a maximal-clique based community detection algorithm to gut microbiome data reveals driver microbes during influenza A virus infection

Author

Bhar, Anirban, primary, Gierse, Laurin Christopher, additional, Meene, Alexander, additional, Wang, Haitao, additional, Karte, Claudia, additional, Schwaiger, Theresa, additional, Schröder, Charlotte, additional, Mettenleiter, Thomas C., additional, Urich, Tim, additional, Riedel, Katharina, additional, and Kaderali, Lars, additional

Published
2022
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9. Influenza A H1N1 Induced Disturbance of the Respiratory and Fecal Microbiome of German Landrace Pigs – a Multi-Omics Characterization

Author

Gierse, Laurin Christopher, primary, Meene, Alexander, additional, Schultz, Daniel, additional, Schwaiger, Theresa, additional, Schröder, Charlotte, additional, Mücke, Pierre, additional, Zühlke, Daniela, additional, Hinzke, Tjorven, additional, Wang, Haitao, additional, Methling, Karen, additional, Kreikemeyer, Bernd, additional, Bernhardt, Jörg, additional, Becher, Dörte, additional, Mettenleiter, Thomas C., additional, Lalk, Michael, additional, Urich, Tim, additional, and Riedel, Katharina, additional

Published
2021
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13. Clinical, neuropathological, and immunological short‐ and long‐term feature of a mouse model mimicking human herpes virus encephalitis.

Author

Sehl‐Ewert, Julia, Schwaiger, Theresa, Schäfer, Alexander, Hölper, Julia E., Klupp, Barbara G., Teifke, Jens P., Blohm, Ulrike, and Mettenleiter, Thomas C.

Subjects
*ENCEPHALITIS viruses, *LABORATORY mice, *NEUROLOGICAL disorders, *ANIMAL disease models, *HERPES simplex virus, *CENTRAL nervous system
Abstract

Herpes simplex encephalitis (HSE) is one of the most serious diseases of the nervous system in humans. However, its pathogenesis is still only poorly understood. Although several mouse models of predominantly herpes simplex virus 1 (HSV‐1) infections mimic different crucial aspects of HSE, central questions remain unanswered. They comprise the specific temporofrontal tropism, viral spread within the central nervous system (CNS), as well as potential molecular and immunological barriers that drive virus into latency while only rarely resulting in severe HSE. We have recently proposed an alternative mouse model by using a pseudorabies virus (PrV) mutant that more faithfully represents the striking features of human HSE: temporofrontal meningoencephalitis with few severely, but generally only moderately to subclinically affected mice as well as characteristic behavioral abnormalities. Here, we characterized this animal model using 6‐ to 8‐week‐old female CD‐1 mice in more detail. Long‐term investigation over 6 months consistently revealed a biphasic course of infection accompanied by recurring clinical signs including behavioral alterations and mainly mild meningoencephalitis restricted to the temporal and frontal lobes. By histopathological and immunological analyses, we followed the kinetics and spatial distribution of inflammatory lesions as well as the underlying cytokine expression in the CNS over 21 days within the acute phase of infection. Affecting the temporal lobes, the inflammatory infiltrate was composed of lymphocytes and macrophages showing a predominantly lymphocytic shift 15 days after infection. A strong increase was observed in cytokines CXCL10, CCL2, CCL5, and CXCL1 recruiting inflammatory cells to the CNS. Unlike the majority of infected mice, strongly affected animals demonstrated extensive temporal lobe edema, which is typically present in severe human HSE cases. In summary, these results support the validity of our animal model for in‐depth investigation of HSE pathogenesis. [ABSTRACT FROM AUTHOR]

Published
2022
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19. Double-attenuated influenza virus elicits broad protection against challenge viruses with different serotypes in swine

Author

Mamerow, Svenja, primary, Scheffter, Robert, additional, Röhrs, Susanne, additional, Stech, Olga, additional, Blohm, Ulrike, additional, Schwaiger, Theresa, additional, Schröder, Charlotte, additional, Ulrich, Reiner, additional, Schinköthe, Jan, additional, Beer, Martin, additional, Mettenleiter, Thomas C., additional, and Stech, Jürgen, additional

Published
2019
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21. Tumour-specific delivery of siRNA-coupled superparamagnetic iron oxide nanoparticles, targeted against PLK1, stops progression of pancreatic cancer

Author

Mahajan, Ujjwal M, primary, Teller, Steffen, additional, Sendler, Matthias, additional, Palankar, Raghavendra, additional, van den Brandt, Cindy, additional, Schwaiger, Theresa, additional, Kühn, Jens-Peter, additional, Ribback, Silvia, additional, Glöckl, Gunnar, additional, Evert, Matthias, additional, Weitschies, Werner, additional, Hosten, Norbert, additional, Dombrowski, Frank, additional, Delcea, Mihaela, additional, Weiss, Frank-Ulrich, additional, Lerch, Markus M, additional, and Mayerle, Julia, additional

Published
2016
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23. Cathepsin D expression in pancreatic ductal adenocarcinoma (PDAC) cells increases proliferation and reduces survival of pancreatic cancer patients

Author

Langhoff, Enno, primary, Mahajan, Ujjwal, additional, Costello, Eithne, additional, Greenhalf, William, additional, Halloran, Christopher, additional, Schwaiger, Theresa, additional, Beyer, Georg, additional, Weiss, Frank-Ullrich, additional, Neoptolemos, John, additional, Kohlmann, Thomas, additional, Marron, Manuela, additional, Büchler, Markus, additional, Lerch, Markus, additional, and Meyerle, Julia, additional

Published
2015
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24. 41 Cathepsin D Expression in Pancreatic Ductal Adenocarcinoma (PDAC) Cells Increases Proliferation and Reduces Survival of Pancreatic Cancer Patients

Author

Mahajan, Ujjwal M., primary, Langhoff, Enno, additional, Costello, Eithne, additional, Greenhalf, William, additional, Halloran, Christopher, additional, Schwaiger, Theresa, additional, Weiss, Frank-Ulrich, additional, Neoptolemos, John, additional, Buchler, Markus W., additional, Lerch, Markus M., additional, and Mayerle, Julia, additional

Published
2015
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28. Effect of magnesium supplementation and depletion on the onset and course of acute experimental pancreatitis

Author

Schick, Verena, primary, Scheiber, Jonas A, additional, Mooren, Frank C, additional, Turi, Stefan, additional, Ceyhan, Güralp O, additional, Schnekenburger, Jürgen, additional, Sendler, Matthias, additional, Schwaiger, Theresa, additional, Omercevic, Armin, additional, Brandt, Cindy van den, additional, Fluhr, Gabriele, additional, Domschke, Wolfram, additional, Krüger, Burkhard, additional, Mayerle, Julia, additional, and Lerch, Markus M, additional

Published
2013
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29. In vivo imaging and targeted siRNA delivery using superparamagnetic nanoparticles in pancreatic ductal adenocarcinoma

Author

Mahajan, Ujwal Mukund, primary, Teller, Steffen, additional, Sendler, Matthias, additional, Schwaiger, Theresa, additional, Glöckl, Gunner, additional, Aurich, Konstanze, additional, Partecke, Lars Ivo, additional, Hadlich, Steffen, additional, Weiss, Frank Ulrich, additional, Kühn, Jens P., additional, Tuveson, David, additional, Lerch, Markus M., additional, and Mayerle, Julia, additional

Published
2013
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30. Autoimmune pancreatitis in MRL/Mp mice is a T cell-mediated disease responsive to cyclosporine A and rapamycin treatment

Author

Schwaiger, Theresa, primary, van den Brandt, Cindy, additional, Fitzner, Brit, additional, Zaatreh, Sarah, additional, Kraatz, Franziska, additional, Dummer, Annegret, additional, Nizze, Horst, additional, Evert, Matthias, additional, Bröker, Barbara M, additional, Brunner-Weinzierl, Monika C, additional, Wartmann, Thomas, additional, Salem, Tareq, additional, Lerch, Markus M, additional, Jaster, Robert, additional, and Mayerle, Julia, additional

Published
2013
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31. A Multi-Omics Protocol for Swine Feces to Elucidate Longitudinal Dynamics in Microbiome Structure and Function.

Author

Gierse, Laurin Christopher, Meene, Alexander, Schultz, Daniel, Schwaiger, Theresa, Karte, Claudia, Schröder, Charlotte, Wang, Haitao, Wünsche, Christine, Methling, Karen, Kreikemeyer, Bernd, Fuchs, Stephan, Bernhardt, Jörg, Becher, Dörte, Lalk, Michael, Study Group, KoInfekt, Urich, Tim, and Riedel, Katharina

Subjects
GUT microbiome, SWINE, SHORT-chain fatty acids, DATA integration, FECAL analysis, LACTOBACILLACEAE
Abstract

Swine are regarded as promising biomedical models, but the dynamics of their gastrointestinal microbiome have been much less investigated than that of humans or mice. The aim of this study was to establish an integrated multi-omics protocol to investigate the fecal microbiome of healthy swine. To this end, a preparation and analysis protocol including integrated sample preparation for meta-omics analyses of deep-frozen feces was developed. Subsequent data integration linked microbiome composition with function, and metabolic activity with protein inventories, i.e., 16S rRNA data and expressed proteins, and identified proteins with corresponding metabolites. 16S rRNA gene amplicon and metaproteomics analyses revealed a fecal microbiome dominated by Prevotellaceae, Lactobacillaceae, Lachnospiraceae, Ruminococcaceae and Clostridiaceae. Similar microbiome compositions in feces and colon, but not ileum samples, were observed, showing that feces can serve as minimal-invasive proxy for porcine colon microbiomes. Longitudinal dynamics in composition, e.g., temporal decreased abundance of Lactobacillaceae and Streptococcaceae during the experiment, were not reflected in microbiome function. Instead, metaproteomics and metabolomics showed a rather stable functional state, as evident from short-chain fatty acids (SCFA) profiles and associated metaproteome functions, pointing towards functional redundancy among microbiome constituents. In conclusion, our pipeline generates congruent data from different omics approaches on the taxonomy and functionality of the intestinal microbiome of swine. [ABSTRACT FROM AUTHOR]

Published
2020
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